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https://www.readbyqxmd.com/read/29658985/using-rotational-thromboelastometry-clot-firmness-at-5-minutes-rotem-%C3%A2-extem-a5-to-predict-massive-transfusion-and-in-hospital-mortality-in-trauma-a-retrospective-analysis-of-1146-patients
#1
J M Kelly, S Rizoli, P Veigas, S Hollands, A Min
Viscoelastic assays such as TEG® and ROTEM® are increasingly used to guide transfusion of blood products. The EXTEM assay maximum clot firmness (MCF) is a ROTEM measure available after 25-29 min used to guide early decisions. EXTEM A10, the clot firmness at 10 min, is an accepted early surrogate, but investigators differ on whether A5, the clot firmness at 5 min, is acceptable. We re-examined this in a retrospective observational analysis of 1146 trauma patients in one centre who had ROTEM data recorded. A5 and A10 both correlated well with maximum clot firmness, with Pearson coefficients of r = 0...
April 16, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29652280/relationship-between-maximum-clot-firmness-in-rotem-%C3%A2-and-postoperative-bleeding-after-coronary-artery-bypass-graft-surgery-in-patients-using-clopidogrel
#2
Rasoul Azarfarin, Fereidoon Noohi, Majid Kiavar, Ziae Totonchi, Avaz Heidarpour, Amir Hendiani, Zahra Sadat Koleini, Saeid Rahimi
Background: The aim of the present study was to investigate the relationship between maximum clot firmness (MCF) in rotational thromboelastometry (ROTEM® ) and postoperative bleeding in patients on clopidogrel after emergency coronary artery bypass graft surgery (CABG). Methods: This observational study recruited 60 patients posted for emergency CABG following unsuccessful primary percutaneous coronary intervention (PCI) while on 600 mg of clopidogrel. The study population was divided into 2 groups on the basis of their MCF in the extrinsically activated thromboelastometric (EXTEM) component of the (preoperative) ROTEM® test: patients with MCF <50 mm (n = 16) and those with MCF ≥50 mm (n = 44)...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29622876/cupincin-a-novel-cupin-domain-containing-protease-from-rice-oryza-sativa-l-bran-comprising-of-procoagulant-and-fibrinogenolytic-activity
#3
Roopesh Sreedhar, Purnima Kaul Tiku
The current study was carried out to evaluate the pharmacological properties of cupincin- A novel cupin domain containing metalloprotease with limited proteolysis from rice bran on blood coagulation and hydrolysis of human fibrinogen. Cupincin preferentially hydrolyzed the Aα chain of fibrinogen and then the Bβ-chain, but not the γ-chain. Cupincin reduced the re-calcification time of citrated human plasma dose dependently. Analysis of citrated whole blood in the presence of cupincin by rotem showed a decrease in coagulation time and clot formation time...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29615381/hyperfibrinolysis-diagnosed-with-rotational-thromboelastometry-and-treated-with-tranexamic-acid-in-a-dog-with-acute-traumatic-coagulopathy
#4
B Muri, P Schmierer, A Schwarz, N Sigrist
A 4-year old male Australian Cattle Dog involved in a road traffic accident was presented with severe polytrauma to the Small Animal Clinic, University of Zurich. He was presented in hemorrhagic shock, with an initial lactate of 10.3mmol/l and ongoing bleeding from multiple injury sites. Acute traumatic coagulopathy diagnosed with ROTEM within one hour after accident showed marked hypocoagulation and hyperfibrinolysis. Treatment with a total dose of 40mg/kg of tranexamic acid intravenously resulted in successful elimination of hyperfibrinolysis in the following, serially measured ROTEM tracings...
April 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29604163/multicenter-in-vitro-thromboelastography-and-thromboelastometry-standardization
#5
Robert Goggs, Antonio Borrelli, Benjamin M Brainard, Daniel L Chan, Armelle de Laforcade, Isabelle Goy-Thollot, Karl E Jandrey, Annemarie T Kristensen, Annette Kutter, Clara B Marschner, Benoît Rannou, Nadja Sigrist, Catherine Wagg
OBJECTIVE: To establish and compare the repeatability and reproducibility of activated thromboelastography (TEG) and thromboelastometry (ROTEM) assays. DESIGN: Multicenter in vitro test standardization. SETTING: Veterinary academic centers. ANIMALS: Test samples were obtained from normal, healthy dogs. Sixty identical 5 mL aliquots of canine platelet-rich plasma collected by apheresis, frozen in 6% dimethyl sulfoxide, were tested initially...
March 31, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29603388/clinically-significant-change-in-posttraumatic-stress-disorder-symptoms-is-associated-with-lower-levels-of-aggression-after-residential-treatment-discharge
#6
Laura E Watkins, Lauren M Sippel, Robert H Pietrzak, Rani Hoff, Ilan Harpaz-Rotem
Although the link between posttraumatic stress disorder (PTSD) and aggression has been repeatedly demonstrated, to our knowledge no research has examined whether PTSD symptom reductions are linked to less aggression after treatment. The current study aimed to address this gap in the literature by examining the association between reductions in PTSD symptoms and posttreatment aggression among 2,275 veterans in residential treatment for PTSD across 35 Veterans Health Administration sites. We estimated a multilevel model that examined the effect of clinically significant PTSD symptom change on aggression at 4-month posttreatment follow-up, and found significant within-site and between-site contextual effects of clinically significant changes in PTSD symptoms on follow-up aggression...
March 30, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29594460/does-endoscopic-puncture-of-ureterocele-provide-not-only-an-initial-solution-but-also-a-definitive-treatment-in-all-children-over-the-26-years-of-experience
#7
Jaber Jawdat, Shachar Rotem, Stanislav Kocherov, Amicur Farkas, Boris Chertin
PURPOSE: We have retrospectively evaluated all patients who underwent endoscopic puncture (EP) of ureterocele over the last 26 years with special reference to the need in the second intervention and disease-free status. METHODS: 78 (69%) of the 112 patients following EP and completed follow-up were included. 51 (65%) were diagnosed prenatally and 27 (35%) postnatally. 46 patients (60%) had intravesical, while 32 (40%) had ectopic ureterocele. Median age at time of puncture was 4 months...
March 29, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29570147/nutrition-in-pediatric-inflammatory-bowel-disease-a-position-paper-on-behalf-of-the-porto-inflammatory-bowel-disease-group-of-the-european-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#8
Erasmo Miele, Raanan Shamir, Marina Aloi, Amit Assa, Christian Braegger, Jiri Bronsky, Lissy de Ridder, Johanna C Escher, Iva Hojsak, Sanja Kolaček, Sibylle Koletzko, Arie Levine, Paolo Lionetti, Massimo Martinelli, Frank Ruemmele, Richard K Russell, Rotem Sigall Boneh, Johan van Limbergen, Gigi Veereman, Annamaria Staiano
BACKGROUND AND AIMS: A growing body of evidence supports the need for detailed attention to nutrition and diet in children with inflammatory bowel disease (IBD). We aimed to define the steps in instituting dietary or nutritional management in light of the current evidence and to offer a useful and practical guide to physicians and dieticians involved in the care of pediatric IBD patients. METHODS: A group of 20 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to Nutrition Committee of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition Porto, IBD Interest, and Nutrition Committee...
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29567716/locally-translated-mtor-controls-axonal-local-translation-in-nerve-injury
#9
Marco Terenzio, Sandip Koley, Nitzan Samra, Ida Rishal, Qian Zhao, Pabitra K Sahoo, Anatoly Urisman, Letizia Marvaldi, Juan A Oses-Prieto, Craig Forester, Cynthia Gomes, Ashley L Kalinski, Agostina Di Pizio, Ella Doron-Mandel, Rotem Ben-Tov Perry, Indrek Koppel, Jeffery L Twiss, Alma L Burlingame, Mike Fainzilber
How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured axons, owing to local translation of mTOR messenger RNA (mRNA). This mRNA was transported into axons by the cell size-regulating RNA-binding protein nucleolin. Furthermore, mTOR controlled local translation in injured axons. This included regulation of its own translation and that of retrograde injury signaling molecules such as importin β1 and STAT3 (signal transducer and activator of transcription 3)...
March 23, 2018: Science
https://www.readbyqxmd.com/read/29557885/the-s100a10-pathway-mediates-an-occult-hyperfibrinolytic-subtype-in-trauma-patients
#10
Lewis S Gall, Paul Vulliamy, Scarlett Gillespie, Timothy F Jones, Rochelle S J Pierre, Sabine E Breukers, Christine Gaarder, Nicole P Juffermans, Marc Maegele, Jakob Stensballe, Pär I Johansson, Ross A Davenport, Karim Brohi
OBJECTIVE: To determine the characteristics of trauma patients with low levels of fibrinolysis as detected by viscoelastic hemostatic assay (VHA) and explore the underlying mechanisms of this subtype. BACKGROUND: Hyperfibrinolysis is a central component of acute traumatic coagulopathy but a group of patients present with low levels of VHA-detected fibrinolysis. There is concern that these patients may be at risk of thrombosis if empirically administered an antifibrinolytic agent...
March 19, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29556702/functional-mri-in-transplanted-kidneys
#11
Alexandra Ljimani, Hans-Jörg Wittsack, Rotem S Lanzman
Renal transplantation is the therapy of choice for patients with end-stage renal diseases. Improvement of immunosuppressive therapy has significantly increased the half-life of renal allografts over the past decade. Nevertheless, complications can still arise. An early detection of allograft dysfunction is mandatory for a good outcome. New advances in magnetic resonance imaging (MRI) have enabled the noninvasive assessment of different functional renal parameters in addition to anatomic imaging. Most of these techniques were widely tested on renal allografts in past decades and a lot of clinical data are available...
March 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29554042/effects-of-platelet-sparing-leukocyte-reduction-and-agitation-methods-on-in-vitro-measures-of-hemostatic-function-in-cold-stored-whole-blood
#12
Kenneth E Remy, Mark H Yazer, Arun Saini, Ajlana Mehanovic-Varmaz, Sharon R Rogers, Col Andrew P Cap, Philip C Spinella
BACKGROUND: Agitation of platelet units stored at room temperature is performed routinely to maintain platelet function and leukoreduction of blood products is standard of care in many countries to reduce immune consequences of transfusion. The effect of agitation and leukoreduction on whole blood stored at 4° C requires investigation as reductions in hemostatic capacity of whole blood may reduce its efficacy in treating trauma-induced coagulopathy and platelet dysfunction. We hypothesize that agitation of whole blood will not affect hemostatic function and that leukoreduction will reduce hemostatic function of whole blood...
March 16, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29544395/evaluation-of-hypercoagulability-with-rotational-thromboelastometry-in-children-with-iron-deficiency-anemia
#13
Zeynep Canan Özdemir, Yeter Düzenli Kar, Eren Gündüz, Ayşe Bozkurt Turhan, Özcan Bör
OBJECTIVE: Iron deficiency anemia (IDA) has been demonstrated to be a risk factor for thromboembolic events, although the pathogenesis of the development of thromboembolism in IDA is as yet unclear. The likelihood of children with IDA contracting hypercoagulability was evaluated in this cross-sectional study using rotational thromboelastometry (ROTEM). MATERIAL AND METHOD: A total of 57 children with IDA (median age 11 years; 37 female, 20 male) and 48 healthy children (median age 9...
March 15, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29543696/global-variation-in-use-of-enteral-nutrition-for-pediatric-crohn-disease
#14
Morgan Lawley, Jessica W Wu, Victor M Navas-López, Hien Q Huynh, Matthew W Carroll, Min Chen, Pavel Medvedev, Andrew S Day, Séamus Hussey, Rotem Sigall-Boneh, Arie Levine, Eytan Wine
OBJECTIVES: Exclusive enteral nutrition (EEN) is an effective induction treatment for pediatric Crohn disease. Given the center-based variation in use and diversity in practice we constructed a survey aimed at sharing experience and strategies in administering EEN, stimulating further research, and optimizing therapy. METHODS: This survey was constructed after consultation with experts and designed to address key knowledge gaps. The survey was disseminated through the Paediatric IBD Porto Group of ESPGHAN, Canadian Children IBD Network, selective experts, and was sent twice through the PEDGI-BB...
March 14, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29538225/interventional-vitamin-c-a-strategy-for-attenuation-of-coagulopathy-and-inflammation-in-a-swine-polytrauma-model
#15
Penny S Reynolds, Bernard J Fisher, Jacquelyn McCarter, Christopher Sweeney, Erika J Martin, Paul Middleton, Matthew Ellenberg, Evan Fowler, Donald F Brophy, Alpha A Fowler, Bruce D Spiess, Ramesh Natarajan
BACKGROUND: Coagulopathy and inflammation induced by hemorrhagic shock and traumatic injury are associated with increased mortality and morbidity. Vitamin C (VitC) is an antioxidant with potential protective effects on the pro-inflammatory and pro-coagulant pathways. We hypothesized that high-dose VitC administered as a supplement to fluid resuscitation would attenuate inflammation, coagulation dysfunction, and end-organ tissue damage in a swine model of polytrauma and hemorrhage. METHODS: Male Sinclair swine (n = 24; mean body weight 27 kg) were anesthetized, intubated, mechanically ventilated, and instrumented for physiological monitoring...
March 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29526150/maternal-and-neonatal-hyponatremia-during-labor-a-case-series
#16
Neta Solomon, Ariel Many, Rotem Orbach, Dror Mandel, Shiri Shinar
BACKGROUND: Hyponatremia during labor and delivery may result in severe maternal and neonatal sequelae. Our aim was to describe the direct effect of hyponatremia in labor on pregnancy outcome. METHODS: A case series of parturients diagnosed with hyponatremia during labor and their neonates. Clinical presentation, laboratory workup, and maternal and neonatal outcomes are presented. RESULTS: Four parturients and their corresponding six neonates were diagnosed with hyponatremia...
March 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29523542/virulence-traits-of-environmental-and-clinical-legionella-pneumophila-mlva-genotypes
#17
Yehonatan Sharaby, Sarah Rodríguez-Martínez, Marina Pecellin, Rotem Sela, Avi Peretz, Manfred Höfle, Malka Halpern, Ingrid Brettar
Legionella pneumophila causes water-based infections resulting in severe pneumonia. Recently, we showed that different variable numbers of tandem repeat analysis (MLVA-8) genotypes dominated different sites of a drinking-water distribution system, with a genotype-related temperature and abundance regime. Here we compare the pathogenicity potential of different MLVA-8 genotypes of environmental and clinical strains. The virulence traits studied were hemolytic activity and cytotoxicity towards amoebae and macrophages...
March 9, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29522808/behavioral-reconsolidation-interference-with-episodic-memory-within-subjects-is-elusive
#18
Daniel A Levy, Rotem Mika, Cecilia Radzyminski, Shir Ben-Zvi, Roni Tibon
In studies of behavioral reconsolidation interference, reactivation of a consolidated memory using some form of reminder is followed by the presentation of new information that can cause interference with that memory. Under these conditions, the interference not only impairs retrieval by indirect processes such as cue interference, but supposedly disrupts the original memory trace directly. Almost all studies of behavioral reconsolidation interference in episodic memory in humans have employed between-subjects paradigms, and deduced reminder effects from intrusion errors...
March 6, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29522746/contemporary-phage-biology-from-classic-models-to-new-insights
#19
REVIEW
Gal Ofir, Rotem Sorek
Bacteriophages, discovered about a century ago, have been pivotal as models for understanding the fundamental principles of molecular biology. While interest in phage biology declined after the phage "golden era," key recent developments, including advances in phage genomics, microscopy, and the discovery of the CRISPR-Cas anti-phage defense system, have sparked a renaissance in phage research in the past decade. This review highlights recently discovered unexpected complexities in phage biology, describes a new arsenal of phage genes that help them overcome bacterial defenses, and discusses advances toward documentation of the phage biodiversity on a global scale...
March 8, 2018: Cell
https://www.readbyqxmd.com/read/29522154/rsrc1-mutation-affects-intellect-and-behaviour-through-aberrant-splicing-and-transcription-downregulating-igfbp3
#20
Yonatan Perez, Shay Menascu, Idan Cohen, Rotem Kadir, Omer Basha, Zamir Shorer, Hila Romi, Gal Meiri, Tatiana Rabinski, Rivka Ofir, Esti Yeger-Lotem, Ohad S Birk
RSRC1, whose polymorphism is associated with altered brain function in schizophrenia, is a member of the serine and arginine rich-related protein family. Through homozygosity mapping and whole exome sequencing we show that RSRC1 mutation causes an autosomal recessive syndrome of intellectual disability, aberrant behaviour, hypotonia and mild facial dysmorphism with normal brain MRI. Further, we show that RSRC1 is ubiquitously expressed, and that the RSRC1 mutation triggers nonsense-mediated mRNA decay of the RSRC1 transcript in patients' fibroblasts...
April 1, 2018: Brain: a Journal of Neurology
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