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https://www.readbyqxmd.com/read/28812425/nasunin-inhibits-the-lipopolysaccharide-induced-pro-inflammatory-mediator-production-in-raw264-mouse-macrophages-by-suppressing-ros-mediated-activation-of-pi3%C3%A2-k-akt-nf-%C3%AE%C2%BAb-and-p38-signaling-pathways
#1
Wataru Komatsu, Kazuko Itoh, Satomi Akutsu, Hisashi Kishi, Shuji Ohhira
Nasunin is a major anthocyanin in eggplant peel. The purpose of this study was to examine the anti-inflammatory effects of nasunin in lipopolysaccharide (LPS)-stimulated RAW264 macrophages and to identify the molecular mechanisms underlying these effects. We found that nasunin reduced the LPS-induced secretion of tumor necrosis factor-α, interleukin-6 and nitric oxide, and expression of inducible nitric oxide synthase in a dose-dependent manner. Nasunin diminished LPS-induced nuclear factor-κB (NF-κB) activation by suppressing the degradation of inhibitor of κB-α and nuclear translocation of p65 subunit of NF-κB...
August 16, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28812133/-watchful-waiting-as-a-therapeutic-principle-for-diseases-of-the-vitreoretinal-interface
#2
REVIEW
H Hoerauf, B Kirchhof
Elective surgery of the vitreoretinal interface is currently the most common reason for vitrectomy in Germany. The evaluation and correct interpretation of spectral domain optical coherence tomography (SD-OCT) images is of great importance but the indications for vitrectomy in macular surgery should be based more on patient symptoms and not only the OCT findings. Watchful waiting is highlighted as an alternative therapeutic option in individual patients. This article addresses a number of aspects and discrepancies between findings and patients' level of suffering based on binocular symptoms...
August 15, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28812089/large-scale-all-polycrystalline-diamond-structures-transferred-onto-flexible-parylene-c-films-for-neurotransmitter-sensing
#3
Bin Fan, Yan Zhu, Robert Rechenberg, Cory A Rusinek, Michael F Becker, Wen Li
Boron-doped diamond (BDD) has superior electrochemical properties for bioelectronic systems. However, due to its high synthesis temperature, traditional microfabrication methods have limits to integrating BDD with emerging classes of flexible, polymer-based bioelectronic systems. This paper introduces a novel fabrication solution to this challenge, which features (i) a wafer-scale substrate transfer process with all diamond structures transferred onto a flexible Parylene-C substrate and (ii) Parylene anchors introduced to strengthen the bonding between BDD and Parylene substrates, as demonstrated by a peeling test...
August 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28811935/pars-plana-vitrectomy-with-internal-limiting-membrane-peeling-in-traumatic-macular-hole-14-perfluoropropane-c3f8-versus-silicone-oil-tamponade
#4
Ashraf Bor'i, Mahmoud A Al-Aswad, Ahmed Abdelwahab Saad, Dina Hamada, Ashraf Mahrous
PURPOSE: To evaluate the outcome of 23 G PPV and ILM peeling with 14% C3F8 compared with silicone oil tamponade in cases of TMHs without spontaneous closure. METHODS: A retrospective comparative study included 33 eyes with TMHs; 7 eyes healed spontaneously, and the remaining 26 eyes have been treated with PPV and ILM peeling. Silicone oil was used as a tamponade for children or adults who refused to adopt face-down position (10 cases). In all other cases (16 cases), 14% C3F8 was used...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28810041/morphologic-and-postoperative-fixation-characteristics-of-the-macular-epiretinal-membrane-in-young-patients-undergoing-surgery
#5
Tian Tian, Chunli Chen, Haiying Jin, Qi Zhang, Yu Xu, Shiyuan Wang, Xiang Zhang, Peiquan Zhao
BACKGROUND AND OBJECTIVE: To describe morphologic characteristics, surgical outcomes, postoperative preferred retinal loci (PRL), and fixation stability of epiretinal membranes (ERMs) in young patients. PATIENTS AND METHODS: This retrospective study analyzed 43 eyes of 41 young patients (age range: 0.8 years to 28 years) with ERMs, which were divided into two groups: secondary ERMs (SERMs; n = 28) and idiopathic ERMs (IERMs; n = 13). All 43 eyes underwent 25-gauge vitrectomy and membrane peeling...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28809420/rapid-identification-of-%C3%AE-glucosidase-inhibitors-from-dioscorea-opposita-thunb-peel-extract-by-enzyme-functionalized-fe3o4-magnetic-nanoparticles-coupled-with-hplc-ms-ms
#6
Songsong Zhang, Dandan Wu, Huan Li, Jinhua Zhu, Weiping Hu, Minghua Lu, Xiuhua Liu
Dioscorea opposita Thunb, commonly known as "yam" that has a long dietary therapy history for diabetes, is widely consumed as a botanical dietary supplement and widely cultivated in China. In this work, a method for rapid screening of α-glucosidase inhibitors from Dioscorea opposita Thunb peel extract was developed using α-glucosidase functionalized magnetic nanoparticles (αG-MNPs) as a solid phase extraction absorbent in combination with high performance liquid chromatography-mass spectrometry (HPLC-MS)...
August 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28808926/foveal-microstructure-analysis-in-eyes-with-diabetic-macular-edema-treated-with-vitrectomy
#7
Jiro Kogo, Akira Shiono, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Yasushi Kitaoka, Hitoshi Takagi
INTRODUCTION: The purpose of this study was to evaluate baseline and postoperative factors affecting outcomes after vitrectomy for diabetic macular edema (DME) using optical coherence tomography (OCT). METHODS: Vitrectomy combined with inner limiting membrane (ILM) peeling and additional laser photocoagulation therapy was performed on 36 eyes of 30 DME patients. Evaluations included the logarithm of the minimal angle of resolution (logMAR), best-corrected visual acuity (BCVA) and OCT parameters at baseline and 1, 3, 6, and 12 months postoperatively...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28807574/synthesis-and-evaluation-of-analogs-of-5-z-4-amino-2-butenyl-methylamino-5-deoxyadenosine-mdl-73811-or-abeado-an-inhibitor-of-s-adenosylmethionine-decarboxylase-with-antitrypanosomal-activity
#8
Anthony J Brockway, Oleg A Volkov, Casey C Cosner, Karen S MacMillan, Stephen A Wring, Thomas E Richardson, Michael Peel, Margaret A Phillips, Jef K De Brabander
We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), essential for the survival of the eukaryotic parasite Trypanosoma brucei responsible for Human African Trypanosomiasis (HAT). The lead compound, 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (1, also known as MDL 73811, or AbeAdo), has curative efficacy at a low dosage in a hemolymphatic model of HAT but displayed no demonstrable effect in a mouse model of the CNS stage of HAT due to poor blood-brain barrier permeation...
August 3, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28806973/protective-effects-of-orange-citrus-sinensis-l-peel-aqueous-extract-and-hesperidin-on-oxidative-stress-and-peptic-ulcer-induced-by-alcohol-in-rat
#9
Slimen Selmi, Kais Rtibi, Dhekra Grami, Hichem Sebai, Lamjed Marzouki
BACKGROUND: Massive alcohol drinking can lead to gastric ulcer. In the present study we investigated the gastroprotective effect of Citrus sinensis peel aqueous extract (CSPE) and Hesperidin (H) in ethanol (EtOH) induced oxidative stress and peptic ulcer in rats. METHODS: Seventy adult male Wistar rats were divided into seven groups of 10 each: control, EtOH (4 g/kg b.w.), EtOH + various doses of CSPE (100, 200 and 400 mg/kg, b.w.), EtOH + Hesperidin (50 mg/kg, p...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28805023/onion-allium-cepa-l-peel-extract-ope-regulates-human-sperm-motility-via-protein-kinase-c-mediated-activation-of-the-human-voltage-gated-proton-channel
#10
M R Chae, S J Kang, K P Lee, B R Choi, H K Kim, J K Park, C Y Kim, S W Lee
Onion (Allium cepa L.) and quercetin protect against oxidative damage and have positive effects on multiple functional parameters of spermatozoa, including viability and motility. However, the associated underlying mechanisms of action have not yet been identified. The aim of this study was to investigate the effect of onion peel extract (OPE) on voltage-gated proton (Hv1) channels, which play a critical role in rapid proton extrusion. This process underlies a wide range of physiological processes, particularly male fertility...
August 13, 2017: Andrology
https://www.readbyqxmd.com/read/28804716/open-wedge-high-tibial-osteotomy-with-distal-tubercle-osteotomy-lessens-change-in-patellar-position
#11
Hoon Park, Hyun Woo Kim, Jin Hwa Kam, Dong Hoon Lee
The purpose of this study was to investigate the change in patellar position after open wedge high tibial osteotomy (OWHTO) with distal tubercle osteotomy (DTO), comparing outcomes of conventional OWHTO in young adults with proximal tibia varus deformity but no arthritic manifestations. Thirty-three patients (mean age, 31.8 years) subjected to OWHTO/DTO were matched with 30 patients (mean age, 33.5 years) undergoing conventional OWHTO. Patellar position, as measured in pre- and postoperative standing lateral radiographs, was compared...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28802843/co-concentration-effect-of-silane-with-natural-extract-on-biodegradable-polymeric-films-for-food-packaging
#12
Anbreen Bashir, Sehrish Jabeen, Nafisa Gull, Atif Islam, Misbah Sultan, Abdul Ghaffar, Shahzad Maqsood Khan, Sadia Sagar Iqbal, Tahir Jamil
Novel biodegradable films were prepared by blending guar gum, chitosan and poly (vinyl alcohol) having mint (ME) and grapefruit peel (GE) extracts and crosslinked with nontoxic tetraethoxysilane (TEOS). The co-concentration effect of TEOS with natural extracts on the films was studied. FTIR analysis confirmed the presence of incorporated components and the developed interactions among the polymer chains. The surface morphology of the films by SEM showed the hydrophilic character due to porous network structure...
August 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28801720/functionalized-hydrothermal-carbon-derived-from-waste-pomelo-peel-as-solid-phase-extractant-for-the-removal-of-uranyl-from-aqueous-solution
#13
Feize Li, Yu Tang, Huilin Wang, Jijun Yang, Shoujian Li, Jun Liu, Hong Tu, Jiali Liao, Yuanyou Yang, Ning Liu
To develop a high-performance solid-phase extractant for the separation of uranyl f, pomelo peel, a kind of waste biomass, has been employed as carbon source to prepare carbonaceous matrix through low-temperature hydrothermal carbonization (200 °C, 24 h). After being oxidized by Hummers method, the prepared hydrothermal carbon matrix was functionalized with carboxyl and phenolic hydroxyl groups (1.75 mmol g(-1)). The relevant characterizations and batch studies had demonstrated that the obtained carbon material possessed excellent affinity toward uranyl (436...
August 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28799792/effects-of-daily-food-processing-on-allergenicity
#14
Beatriz Cabanillas, Natalija Novak
Daily food processing has the potential to alter the allergenicity of foods due to modification of the physico-chemical properties of proteins. The degree of such modifications depends on factors such as processing conditions, type of food considered, allergenic content, etc. The impact of daily food processing like boiling, roasting, frying or baking on food allergenicity have been extensively studied. The influence of other thermal treatments such as microwave heating or pressure cooking on allergenicity has also been analyzed...
August 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28799335/structure-and-mechanical-properties-of-polybutadiene-thin-films-bound-to-surface-modified-carbon-interface
#15
Koichiro Hori, Norifumi L Yamada, Yoshihisa Fujii, Tomomi Masui, Hiroyuki Kishimoto, Hideki Seto
The structure and mechanical properties of polybutadiene (PB) film on bare and surface-modified carbon films were examined. There was an interfacial layer of PB near the carbon layer whose density was higher (lower) than that of the bulk material on the hydrophobic (hydrophilic) carbon surface. To glean information about the structure and mechanical properties of PB at the carbon interface, a residual layer (RL) adhering on the carbon surface, which was considered to be a model of "bound rubber layer," was obtained by rinsing the PB film with toluene...
August 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28798753/fine-mapping-of-a-gene-er4-1-that-causes-epidermal-reticulation-of-tomato-fruit-and-characterization-of-the-associated-transcriptome
#16
Lipeng Cui, Zhengkun Qiu, Zhirong Wang, Jianchang Gao, Yanmei Guo, Zejun Huang, Yongchen Du, Xiaoxuan Wang
The hydrophobic cuticle that covers the surface of tomato (Solanum lycopersicum) fruit plays key roles in development and protection against biotic and abiotic stresses, including water loss, mechanical damage, UV radiation, pathogens, and pests. However, many details of the genes and regulatory mechanisms involved in cuticle biosynthesis in fleshy fruits are not well understood. In this study, we describe a novel tomato fruit phenotype, characterized by epidermal reticulation (ER) of green fruit and a higher water loss rate than wild type (WT) fruit...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28796657/microneedling-a-review-and-practical-guide
#17
Tina S Alster, Paul M Graham
BACKGROUND: Microneedling is a relatively new treatment option in dermatology and has been touted for a broad range of applications including skin rejuvenation, acne scarring, rhytides, surgical scars, dyschromia, melasma, enlarged pores, and transdermal drug delivery. The significant increase in minimally invasive procedures that has been reported over the past several years suggest that microneedling may occupy a specific niche for patients who desire measurable clinical results from treatments with little to no recovery...
August 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28796147/surgical-outcomes-in-eyes-with-extremely-high-myopia-for-macular-hole-without-retinal-detachment
#18
Tsung-Tien Wu, Ya-Hsin Kung, Chih-Yao Chang, Shu-Ping Chang
PURPOSE: The authors evaluated surgical outcomes in eyes with extremely high myopia for macular hole (MH) without retinal detachment. METHODS: In this retrospective study, 14 eyes with axial lengths of ≥30.0 mm underwent vitrectomy and internal limiting membrane (ILM) peeling with or without inverted ILM flap insertion for MH without retinal detachment (October 2009-June 2016). Outcome measures were MH closure confirmed by optical coherence tomography, best-corrected visual acuity, and complications...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28796146/hole-door-sign-a-novel-intraoperative-optical-coherence-tomography-feature-predicting-macular-hole-closure
#19
Vinod Kumar, Bhupendra Yadav
PURPOSE: To describe a novel intraoperative finding during pars plana vitrectomy for macular hole using operating microscope-integrated spectral domain optical coherence tomography that predicts the closure of macular hole. METHODS: Twenty-five eyes of 25 patients with macular hole, who underwent 25-gauge pars plana vitrectomy over a period of 16 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. All eyes were assessed with intraoperative spectral domain optical coherence tomography before and after internal limiting membrane peeling...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28795986/orange-peel-excision-of-gland-a-novel-surgical-technique-for-treatment-of-gynecomastia
#20
S S Shirol
No abstract text is available yet for this article.
September 2017: Annals of Plastic Surgery
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