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fMRI & encephalopathy

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https://www.readbyqxmd.com/read/27717156/combining-arterial-spin-labeling-with-functional-magnetic-resonance-imaging-measurement-for-characterizing-patients-with-minimal-hepatic-encephalopathy
#1
Ying Li, Huaijun Liu, Jiping Yang, Xin Tian, Haiqing Yang, Zuojun Geng
AIM: Our objective is to explore key changes in brain functions in relation to minimal hepatic encephalopathy (MHE). We incorporated both resting-state functional magnetic resonance imaging (fMRI) and arterial spin labeling (ASL) to enhance the detection of MHE. METHODS: We undertook fMRI scanning for 56 MHE patients and 66 healthy controls. Region functional connectivity was carried out to assess the connectivity status between pairs of regions among 90 brain regions...
October 7, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27339647/liver-transplantation-significantly-improves-global-functioning-and-cerebral-processing
#2
Vishwadeep Ahluwalia, James B Wade, Melanie B White, HoChong S Gilles, Douglas M Heuman, Michael Fuchs, Edith A Gavis, Andrew Fagan, Felicia Tinsley, Dinesh Ganapathy, Leroy R Thacker, Richard K Sterling, R Todd Stravitz, Puneet Puri, Arun J Sanyal, Muhammad S Siddiqui, Scott Matherly, Velimir Luketic, Joel Steinberg, F Gerard Moeller, Jasmohan S Bajaj
The functional basis of cognitive and quality of life changes after liver transplant is unclear. We aimed to evaluate the neurometabolic and functional brain changes as modulators of cognition and quality of life after transplant in patients with cirrhosis who were with/without pretransplant cognitive impairment and hepatic encephalopathy (HE). Patients with cirrhosis underwent detailed cognitive and quality of life assessment at enrollment and 6 months after transplant. A subset underwent brain magnetic resonance imaging (functional magnetic resonance imaging [fMRI], diffusion tensor imaging [DTI], and magnetic resonance spectroscopy [MRS]) before and after transplant...
October 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27295078/epileptic-network-of-hypothalamic-hamartoma-an-eeg-fmri-study
#3
Kiyohide Usami, Riki Matsumoto, Nobukatsu Sawamoto, Hiroatsu Murakami, Morito Inouchi, Tomoyuki Fumuro, Akihiro Shimotake, Takeo Kato, Tatsuya Mima, Hiroshi Shirozu, Hiroshi Masuda, Hidenao Fukuyama, Ryosuke Takahashi, Shigeki Kameyama, Akio Ikeda
OBJECTIVE: To investigate the brain networks involved in epileptogenesis/encephalopathy associated with hypothalamic hamartoma (HH) by EEG with functional MRI (EEG-fMRI), and evaluate its efficacy in locating the HH interface in comparison with subtraction ictal SPECT coregistered to MRI (SISCOM). METHODS: Eight HH patients underwent EEG-fMRI. All had gelastic seizures (GS) and 7 developed other seizure types. Using a general linear model, spike-related activation/deactivation was analyzed individually by applying a hemodynamic response function before, at, and after spike onset (time-shift model=-8-+4s)...
September 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27138528/abnormalities-of-voxel-based-whole-brain-functional-connectivity-patterns-predict-the-progression-of-hepatic-encephalopathy
#4
Gaoyan Zhang, Yue Cheng, Baolin Liu
Resting state functional magnetic resonance imaging (fMRI) is an important tool for understanding the functional reorganization of the brain in cirrhotic patients. Previous studies revealed that functional integration failure were observed in the whole brain. However, the whole-brain functional connectivity analysis methods used in these studies have the limitation that the result relied on a priori definition of network nodes. Moreover, the utility of resting state functional connectivity in the diagnosis and prediction of hepatic encephalopathy (HE) is not well examined...
May 2, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27088064/chronic-traumatic-encephalopathy-the-impact-on-athletes
#5
REVIEW
Michael A Galgano, Robert Cantu, Lawrence S Chin
Chronic traumatic encephalopathy (CTE) is a devastating neuropsychological condition afflicting a small percentage of athletes partaking in high-impact sports. The onset of symptoms lags years behind the inciting events. Repetitive minor head injuries are felt to be the main etiology behind CTE. Routine radiographic imaging generally is unremarkable in cases of CTE. Functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), and diffusion tensor imaging (DTI) are advanced MRI-based sequences that have shown promise in detecting early radiographic findings that may be reflective of CTE...
2016: Curēus
https://www.readbyqxmd.com/read/27002912/altered-regional-homogeneity-in-epileptic-patients-with-infantile-spasm-a-resting-state-fmri-study
#6
Zhen Tan, Yongxin Li, Dongdong Zang, Heye Zhang, Cailei Zhao, Haibo Jiang, Yan Chen, Dezhi Cao, Li Chen, Jianxiang Liao, Qian Chen, Guoming Luan
Infantile spasm (IS) syndrome is an age-related epileptic encephalopathy that occurs in children. The purpose of this study was to investigate regional homogeneity (ReHo) changes in IS patients. Resting-state fMRI was performed on 11 patients with IS, along with 35 age- and sex-matched healthy subjects. Group comparisons between the two groups demonstrate that the pattern of regional synchronization synchronization in IS patients is changed. Decreased ReHo values were found in default mode network, bilateral motor-related areas and left occipital gyrus of the patient group...
2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/26978777/machine-learning-classification-of-cirrhotic-patients-with-and-without-minimal-hepatic-encephalopathy-based-on-regional-homogeneity-of-intrinsic-brain-activity
#7
Qiu-Feng Chen, Hua-Jun Chen, Jun Liu, Tao Sun, Qun-Tai Shen
Machine learning-based approaches play an important role in examining functional magnetic resonance imaging (fMRI) data in a multivariate manner and extracting features predictive of group membership. This study was performed to assess the potential for measuring brain intrinsic activity to identify minimal hepatic encephalopathy (MHE) in cirrhotic patients, using the support vector machine (SVM) method. Resting-state fMRI data were acquired in 16 cirrhotic patients with MHE and 19 cirrhotic patients without MHE...
2016: PloS One
https://www.readbyqxmd.com/read/26945476/abnormal-cognitive-network-interactions-in-lennox-gastaut-syndrome-a-potential-mechanism-of-epileptic-encephalopathy
#8
Aaron E L Warren, David F Abbott, David N Vaughan, Graeme D Jackson, John S Archer
OBJECTIVE: In patients with Lennox-Gastaut syndrome (LGS), recurrent epileptic activity is thought to contribute to impaired cognition (epileptic encephalopathy). Using concurrent electroencephalography-functional magnetic resonance imaging (EEG-fMRI), we recently showed that epileptiform discharges in LGS recruit large-scale networks that normally support key cognitive processes. In LGS, given that epileptic activity engages cognitive networks, and cognition is pervasively impaired, we hypothesized that cognitive network interactions in LGS are persistently abnormal...
May 2016: Epilepsia
https://www.readbyqxmd.com/read/26886109/identifying-minimal-hepatic-encephalopathy-in-cirrhotic-patients-by-measuring-spontaneous-brain-activity
#9
Hua-Jun Chen, Ling Zhang, Long-Feng Jiang, Qiu-Feng Chen, Jun Li, Hai-Bin Shi
It has been demonstrated that minimal hepatic encephalopathy (MHE) is associated with aberrant regional intrinsic brain activity in cirrhotic patients. However, few studies have investigated whether altered intrinsic brain activity can be used as a biomarker of MHE among cirrhotic patients. In this study, 36 cirrhotic patients (with MHE, n = 16; without MHE [NHE], n = 20) underwent resting-state functional magnetic resonance imaging (fMRI). Spontaneous brain activity was measured by examining the amplitude of low-frequency fluctuations (ALFF) in the fMRI signal...
August 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/26875710/-anterior-and-posterior-default-mode-networks-impairments-in-minimal-hepatic-encephalopathy
#10
Yun Jiao, Tianyu Tang, Xunheng Wang, Xiqi Zhu, Gaojun Teng
OBJECTIVE: To investigate the functional connectivity (FC) impairments within anterior and posterior default mode networks (aDMN and pDMN) for cirrhosis with minimal hepatic encephalopathy (MHE), and to analyze relationship between DMNs alterations with neurocognitive impairments. METHODS: From March 2009 to December 2011, a total of 43 cirrhotic patients without MHE (NMHE groups), 32 cirrhotic patients with current MHE (MHE groups), and 21 healthy controls were recruited in this study...
February 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26329994/role-of-local-and-distant-functional-connectivity-density-in-the-development-of-minimal-hepatic-encephalopathy
#11
Rongfeng Qi, Long Jiang Zhang, Hui Juan Chen, Jianhui Zhong, Song Luo, Jun Ke, Qiang Xu, Xiang Kong, Chang Liu, Guang Ming Lu
The progression of functional connectivity (FC) patterns from non-hepatic encephalopathy (non-HE) to minimal HE (MHE) is not well known. This resting-state functional magnetic resonance imaging (rs-fMRI) study investigated the evolution of intrinsic FC patterns from non-HE to MHE. A total of 103 cirrhotic patients (MHE, n = 34 and non-HE, n = 69) and 103 healthy controls underwent rs-fMRI scanning. Maps of distant and local FC density (dFCD and lFCD, respectively) were compared among MHE, non-HE, and healthy control groups...
September 2, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26321490/resting-state-functional-connectivity-abnormalities-correlate-with-psychometric-hepatic-encephalopathy-score-in-cirrhosis
#12
Hua-Jun Chen, Long-Feng Jiang, Tao Sun, Jun Liu, Qiu-Feng Chen, Hai-Bin Shi
BACKGROUND & AIMS: Neurocognitive impairment is a common complication of cirrhosis and regarded as the important characteristic for early stage of hepatic encephalopathy (HE). This study aimed to investigate the changes in brain network centrality of functional connectivity among cirrhotic patients and uncover the mechanisms about early HE. METHODS: Twenty-four cirrhotic patients without overt HE and 21 healthy controls were enrolled and underwent resting-state fMRI and Psychometric Hepatic Encephalopathy Score (PHES) tests...
November 2015: European Journal of Radiology
https://www.readbyqxmd.com/read/26236028/functional-brain-network-changes-associated-with-clinical-and-biochemical-measures-of-the-severity-of-hepatic-encephalopathy
#13
Tun Jao, Manuel Schröter, Chao-Long Chen, Yu-Fan Cheng, Chun-Yi Zac Lo, Kun-Hsien Chou, Ameera X Patel, Wei-Che Lin, Ching-Po Lin, Edward T Bullmore
Functional properties of the brain may be associated with changes in complex brain networks. However, little is known about how properties of large-scale functional brain networks may be altered stepwise in patients with disturbance of consciousness, e.g., an encephalopathy. We used resting-state fMRI data on patients suffering from various degrees of hepatic encephalopathy (HE) to explore how topological and spatial network properties of functional brain networks changed at different cognitive and consciousness states...
November 15, 2015: NeuroImage
https://www.readbyqxmd.com/read/26106307/cortical-signature-of-patients-with-hbv-related-cirrhosis-without-overt-hepatic-encephalopathy-a-morphometric-analysis
#14
Xiu Wu, Xiao-Fei Lv, Yu-Ling Zhang, Hua-Wang Wu, Pei-Qiang Cai, Ying-Wei Qiu, Xue-Lin Zhang, Gui-Hua Jiang
Previous studies have shown that patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt hepatic encephalopathy (OHE) are associated with a varying degree of cognitive dysfunction. Several resting-state functional magnetic resonance imaging (fMRI) studies have been conducted to explore the neural correlates of such cognitive deficits, whereas little effort has been made to investigate the cortical integrity in cirrhotic patients without OHE. Here, using cortical thickness, surface area and local gyrification index (lGI), this study performed a comprehensive analysis on the cortical morphometry of patients with HBV-RC without OHE (HBV-RC-NOHE) vs...
2015: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/26016622/altered-long-and-short-range-functional-connectivity-in-the-patients-with-end-stage-renal-disease-a-resting-state-functional-mri-study
#15
Xiao-Dong Zhang, Ji-Qiu Wen, Qiang Xu, Rongfeng Qi, Hui-Juan Chen, Xiang Kong, Lu-De Wei, Min Xu, Long Jiang Zhang, Guang Ming Lu
To investigate alterations of functional connectivity density (FCD) in patients with end-stage renal disease (ESRD) by using resting-state functional magnetic resonance imaging (rs-fMRI). Medical research ethics committee approval from Jinling hospital and written informed consent from each subject were obtained. Forty six patients with ESRD, consisting of 21 patients minimal nephrotic encephalopathy (MNE) and 25 non-nephro-encephalopathy (non-NE), as well as 23 healthy controls underwent rs-fMRI. Neuropsychological tests were performed in all subjects, while laboratory tests were performed in ESRD patients...
October 2015: Metabolic Brain Disease
https://www.readbyqxmd.com/read/25973853/resting-state-fmri-with-reho-analysis-as-a-non-invasive-modality-for-the-prognosis-of-cirrhotic-patients-with-overt-hepatic-encephalopathy
#16
Wei-Che Lin, Tun-Wei Hsu, Chao-Long Chen, Cheng-Hsien Lu, Hsiu-Ling Chen, Yu-Fan Cheng
BACKGROUND: To investigate the relationships among regional activity abnormalities, clinical disease severity, and prognosis in cirrhotic patients with overt hepatic encephalopathy (OHE) using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: Regional homogeneity (ReHo) values of 12 cirrhotic patients with OHE and 12 age- and sex-matched healthy volunteers were calculated from rs-fMRI. Two-sample t-test was performed on individual ReHo maps between the two groups...
2015: PloS One
https://www.readbyqxmd.com/read/25501083/default-mode-network-functional-connectivity-a-promising-biomarker-for-diagnosing-minimal-hepatic-encephalopathy-consort-compliant-article
#17
Rongfeng Qi, Long Jiang Zhang, Song Luo, Jun Ke, Xiang Kong, Qiang Xu, Chang Liu, Heng Lu, Guang Ming Lu
To investigate the contribution of brain default mode network (DMN) in the early diagnosis of the minimal hepatic encephalopathy (MHE), the mildest form of HE from cirrhotic patients by using resting-state functional magnetic resonance imaging (rs-fMRI). This study was approved by the local ethical committee, and a written informed consent was obtained from each participant. A total of 103 cirrhotic patients (34 MHE, 69 non-HE) and 103 matched healthy controls underwent rs-fMRI scanning. The DMN correlation map was acquired by using unbiased seed-based functional connectivity analysis and compared among MHE patients, non-HE patients, and healthy controls with analysis of variance tests...
December 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25043497/disrupted-small-world-networks-in-patients-without-overt-hepatic-encephalopathy-a-resting-state-fmri-study
#18
Long Jiang Zhang, Gang Zheng, Liping Zhang, Jianhui Zhong, Qiang Li, Tie Zhu Zhao, Guang Ming Lu
PURPOSE: To explore changes in functional connectivity and topological organization of brain functional networks in cirrhotic patients with minimal hepatic encephalopathy (MHE) and non hepatic encephalopathy (nonHE) and their relationship with clinical markers. MATERIALS AND METHODS: Resting-state functional MR imaging was acquired in 22 MHE, 29 nonHE patients and 33 healthy controls. Functional connectivity networks were obtained by computing temporal correlations between any pairs of 90 cortical and subcortical regions...
October 2014: European Journal of Radiology
https://www.readbyqxmd.com/read/25027645/long-term-sequelae-of-severe-sepsis-cognitive-impairment-and-structural-brain-alterations-an-mri-study-losscog-mri
#19
Theresa Götz, Albrecht Günther, Otto W Witte, Frank M Brunkhorst, Gundula Seidel, Farsin Hamzei
BACKGROUND: The number of patients with cognitive impairment after sepsis or septic shock is high. However, the underlying neurophysiological basis of sepsis induced cognitive impairment is not fully understood. METHODS/DESIGN: This is a prospective, controlled observational study. We are in the process of recruiting 25 survivors of severe sepsis or septic shock who will be investigated with functional MRI (fMRI), T1-weighted MRI und Diffusion Tensor Imaging (DTI) as well as Magnetoencephalography (MEG)...
2014: BMC Neurology
https://www.readbyqxmd.com/read/24907446/abnormal-functional-connectivity-within-the-default-mode-network-in-patients-with-hbv-related-cirrhosis-without-hepatic-encephalopathy-revealed-by-resting-state-functional-mri
#20
Rongfeng Qi, Long Jiang Zhang, Qiang Xu, Xue Liang, Song Luo, Zhiqiang Zhang, Wei Huang, Ling Zheng, Guang Ming Lu
By means of "task free" resting-state functional magnetic resonance imaging (rs-fMRI), abnormal functional connectivity (FC) of the default mode network (DMN) in cirrhotic patients with hepatic encephalopathy (HE) has been reported; however, little is known about the changes of DMN in cirrhotic patients without overt or minimal HE. The aim of this study was to investigate whether there was a disruption of the FC within the DMN in patients with hepatitis B virus (HBV)-related cirrhosis without any signs of HE...
August 12, 2014: Brain Research
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