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Cervical cancer and HPV vaccines

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https://www.readbyqxmd.com/read/28413829/prioritizing-us-cervical-cancer-prevention-with-results-from-a-geospatial-model
#1
Jonathan K Kish, Alicia I Rolin, Zhaohui Zou, James E Cucinelli, Zaria Tatalovich, Mona Saraiya, Sean F Altekruse
PURPOSE: To determine if differences in screening and vaccination patterns across the population may accentuate ethnic and geographic variation in future burden of disease. METHODS: Using Cancer in North America data provided by the North American Association of Central Cancer Registries, county cervical cancer incidence trends from 1995 to 2009 were modeled for the entire United States using ecologic covariates. Rates for health service areas were also modeled by ethnicity...
October 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28410118/disparity-in-rates-of-hpv-infection-and-cervical-cancer-in-underserved-us-populations
#2
Asok Ranjan Karuri, Vivek Kumar Kashyap, Murali Mohan Yallapu, Nadeem Zafar, Satish K Kedia, Meena Jaggi, Subhash C Chauhan
There is a higher rate of HPV infection and cervical cancer incidence and mortality in underserved US population who reside in Appalachian mountain region compared to Northern Plains. Social and behavioral factors such as smoking and alcohol consumption are for such a high incidence. However, by and large, the reasons for these discrepancies lie in the reluctance of the underserved population to adopt preventive measures such as prophylactic Human papilloma virus (HPV) vaccines and Pap smear screening that have significantly reduced the incidence and mortality rate of cervical cancer in Caucasian women...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28406406/cervical-cancer-in-sub-saharan-africa-an-emerging-and-preventable-disease-associated-with-oncogenic-human-papillomavirus
#3
R S Mboumba Bouassa, T Prazuck, T Lethu, J F Meye, L Bélec
Highly oncogenic human papillomavirus (HPV) infections are responsible for 7.7 % of cancers in developing countries, mainly cervical cancer. The incidence of this emerging cancer is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and close to 50,000 deaths a year, a toll further increased by HIV infection. According to the World Health Organization, cervical cancer will kill more than 443,000 women per year worldwide by 2030, nearly 90 % of them in sub-Saharan Africa. This increase in cervical cancer incidence in Africa is now counteracting the progress made by African women in reducing maternal mortality and increasing longevity...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28404529/cervical-cancer-human-papillomavirus-and-vaccines-assessment-of-the-information-retrieved-from-general-knowledge-websites-in-chile
#4
C S Lopez, E Krauskopf, C E Villota, L O Burzio, J E Villegas
OBJECTIVES: Cervical cancer is the most common gynaecologic malignancy worldwide and is the sixth cause of cancer death in Chile. Human papillomavirus (HPV) is responsible for most cervical cancers. Individuals seeking basic information about HPV frequently turn to health information websites. We hypothesized that some of their data may be inaccurate. STUDY DESIGN: Comparative analysis of information. METHODS: We analyze the content of highly accessed websites such as the Spanish version of Wikipedia and Yahoo Answers through the application of a questionnaire, as well as a website managed by the Chilean Ministry of Health (Minsal)...
April 3, 2017: Public Health
https://www.readbyqxmd.com/read/28400857/estimation-of-the-overall-burden-of-cancers-precancerous-lesions-and-genital-warts-attributable-to-9-valent-hpv-vaccine-types-in-women-and-men-in-europe
#5
Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany, Silvia de Sanjosé
BACKGROUND: In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital warts. We estimated the annual number of new cases of these diseases attributable to 9-valent HPV vaccine types in women and men in Europe. METHODS: The annual number of new cancers of the cervix, vulva, vagina, anus, penis, and selected head and neck sites in the population of the European Medicines Agency territory was estimated based on age-specific incidence rates extracted from Cancer Incidence in 5 Continents, Volume X and Eurostat population data for 2015...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28389098/identification-and-characterization-of-enhancer-agonist-human-cytotoxic-t-cell-epitopes-of-the-human-papillomavirus-type-16-hpv16-e6-e7
#6
Kwong Y Tsang, Massimo Fantini, Romaine I Fernando, Claudia Palena, Justin M David, James W Hodge, Elizabeth S Gabitzsch, Frank R Jones, Jeffrey Schlom
Human papillomavirus (HPV) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. Vaccines directed against HPV virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host HPV-specific antibody responses; however, HPV-associated cancers remain a major public health problem. The development of a therapeutic vaccine will require the generation of T-cell responses directed against early HPV proteins (E6/E7) expressed in HPV-infected tumor cells...
April 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28382802/major-clinical-research-advances-in-gynecologic-cancer-in-2016-10-year-special-edition
#7
REVIEW
Dong Hoon Suh, Miseon Kim, Kidong Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several targeted agents that showed comparable responses in phase III trials, including niraparib, cediranib, and nintedanib. On the contrary to our expectations, dose-dense weekly chemotherapy regimen failed to prove superior survival outcomes compared with conventional triweekly regimen. Single-agent non-platinum treatment to prolong platinum-free-interval in patients with recurrent, partially platinum-sensitive ovarian cancer did not improve and even worsened overall survival (OS)...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28376222/optimal-cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus
#8
Jane J Kim, Emily A Burger, Stephen Sy, Nicole G Campos
Background: Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated. Methods: We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28369882/worldwide-burden-of-cancer-attributable-to-hpv-by-site-country-and-hpv-type
#9
Catherine de Martel, Martyn Plummer, Jerome Vignat, Silvia Franceschi
HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancer and oropharyngeal cancer. Understanding the HPV-attributable cancer burden can boost programs of HPV vaccination and HPV-based cervical screening. Attributable fractions (AF) and the relative contributions of different HPV types were derived from published studies reporting on the prevalence of transforming HPV infection in cancer tissue. Maps of age-standardized incidence rates of HPV-attributable cancers by country from GLOBOCAN 2012 data are shown separately for the cervix, other anogenital tract, and head and neck cancers...
April 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28363164/effect-of-naturally-acquired-type-specific-serum-antibodies-against-human-papillomavirus-type-16-infection
#10
Tina Triglav, Hanna Artemchuk, Anja Oštrbenk, K Miriam Elfström, Helena Faust, Mario Poljak, Joakim Dillner
BACKGROUND: While vaccine-induced antibodies are known to confer protection against incident human papillomavirus (HPV) infection, there is inconsistent data regarding the protective effect of naturally acquired anti-HPV antibodies. OBJECTIVES: To estimate the protective effect of naturally acquired anti-HPV16 serum antibodies against incident anogenital infection with HPV16 in females aged 20-64 years and to assess whether antibodies influence the persistence/clearance of anogenital HPV16 infection...
March 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28361828/knowledge-attitude-practice-on-human-papillomavirus-vaccination-a-cross-sectional-study-among-healthcare-providers
#11
P Cheena Chawla, Anil Chawla, Seema Chaudhary
BACKGROUND & OBJECTIVES: Cervical cancer is a major health problem and a leading cause of death among women in India. Of all the associated risk factors, high-risk human papillomavirus (HPV) infections being the principal aetiologic agent, two HPV vaccines are in use for the control of cervical cancer. The present study was undertaken to explore the knowledge, attitude and practice (KAP) on HPV vaccination among the healthcare providers in India. METHODS: A cross-sectional study was conducted among 590 healthcare professionals from 232 hospitals and 80 PHCs of nine districts of Delhi-NCR (National Capital Region)...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28357043/recent-advances-in-understanding-and-preventing-human-papillomavirus-related-disease
#12
REVIEW
Karin Hellner, Lucy Dorrell
High-risk human papillomaviruses (hrHPV) are responsible for anogenital and oropharyngeal cancers, which together account for at least 5% of cancers worldwide. Industrialised nations have benefitted from highly effective screening for the prevention of cervical cancer in recent decades, yet this vital intervention remains inaccessible to millions of women in low- and middle-income countries (LMICs), who bear the greatest burden of HPV disease. While there is an urgent need to increase investment in basic health infrastructure and rollout of prophylactic vaccination, there are now unprecedented opportunities to exploit recent scientific and technological advances in screening and treatment of pre-invasive hrHPV lesions and to adapt them for delivery at scale in resource-limited settings...
2017: F1000Research
https://www.readbyqxmd.com/read/28346275/committee-opinion-no-704-human-papillomavirus-vaccination
#13
(no author information available yet)
Human papillomavirus (HPV) is associated with anogenital cancer (including cervical, vaginal, vulvar, penile, and anal), oropharyngeal cancer, and genital warts. The HPV vaccination significantly reduces the incidence of anogenital cancer and genital warts. Despite the benefits of HPV vaccines, only 41.9% of girls in the recommended age group, and only 28.1% of males in the recommended age group have received all recommended doses. Compared with many other countries, HPV vaccination rates in the United States are unacceptably low...
March 24, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28343836/cervical-cancer-prevention-and-early-detection
#14
REVIEW
Theresa A Kessler
OBJECTIVE: To review effective methods of prevention that can be used to control the incidence of cervical cancer and detection strategies that can identify the precancerous lesions before they become true cancer. DATA SOURCES: Current medical, scientific and nursing literature, and national and international guidelines of cervical cancer. CONCLUSION: Nearly all cervical cancers are caused by specific types of human papillomavirus (HPV). Prophylactic vaccination for HPV provides the most effective method of primary prevention against HPV-related diseases...
March 23, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28342625/development-of-a-theory-guided-storytelling-narrative-intervention-to-improve-hpv-vaccination-behavior-save-our-daughters-from-cervical-cancer
#15
Haeok Lee, Minjin Kim, Jeroan Allison, Peter Kiang
No abstract text is available yet for this article.
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28341458/not-just-a-woman-s-business-understanding-men-and-women-s-knowledge-of-hpv-the-hpv-vaccine-and-hpv-associated-cancers
#16
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Kahee A Mohammed, Betelihem B Tobo, Christian J Geneus, Mario Schootman
Few studies have included men when assessing differences in knowledge about HPV, and HPV-associated cancers. We examined gender differences in knowledge about HPV, HPV vaccine, and HPV-associated cancers. Multivariable logistic regression models were used to analyze data of 3,677 survey respondents aged 18 years and older from the 2014 Health Information National Trends Survey. Covariates included age, race/ethnicity, marital status, education, income level, regular provider, general health, internet use, and family structure aged 9 to 27 years...
March 22, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28332774/changing-hpv-vaccination-rates-in-bisexual-and-lesbian-women
#17
Carolee Polek, Thomas Hardie
BACKGROUND: Human papillomavirus (HPV) vaccination rates continue to be below national targets for women and lower in some sexual minorities. HPV is a primary causal agent in cervical cancer, from which members of the lesbian and bisexual community mistakenly believe they are at low risk. This study characterized rates of HPV vaccination in women based on their sexual orientation. METHODS: Data were obtained from the Centers for Disease Control and Prevention's National Health Interview Survey 2013-2014...
March 23, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28330110/sequence-based-approach-for-rapid-identification-of-cross-clade-cd8-t-cell-vaccine-candidates-from-all-high-risk-hpv-strains
#18
Krishna P Singh, Neeraj Verma, Bashir A Akhoon, Vishal Bhatt, Shishir K Gupta, Shailendra K Gupta, Suchi Smita
Human papilloma virus (HPV) is the primary etiological agent responsible for cervical cancer in women. Although in total 16 high-risk HPV strains have been identified so far. Currently available commercial vaccines are designed by targeting mainly HPV16 and HPV18 viral strains as these are the most common strains associated with cervical cancer. Because of the high level of antigenic specificity of HPV capsid antigens, the currently available vaccines are not suitable to provide cross-protection from all other high-risk HPV strains...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28325903/whole-genome-analysis-of-human-papillomavirus-types-16-18-and-58-isolated-from-cervical-precancer-and-cancer-samples-in-chinese-women
#19
Ying Liu, Yaqi Pan, Weijiao Gao, Yang Ke, Zheming Lu
Human papillomavirus (HPV) types 16, 18 and 58 are ranked the top three high-risk HPV types for cervical intraepithelial neoplasia (CIN) and invasive carcinoma. We aimed to evaluate the diversity of HPV16, HPV18, and HPV58 genetic variants by HPV capture technology combined with next generation sequencing. 295, 73, and 148 variations were observed in 51 HPV16, 7 HPV18, and 11 HPV58 genomes, respectively. HPV16 isolates were predominantly of the A variant lineage, and sublineage A4 (Asian) was the most common...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322641/association-between-parental-hpv-knowledge-and-intentions-to-have-their-daughters-vaccinated
#20
Lisa N Mansfield, Elijah O Onsomu, Elizabeth Merwin, Naomi M Hall, Alfreda Harper-Harrison
Human papillomavirus (HPV) 16 and 18 causes 66% of cervical cancers (Dunne et al., 2014). Vaccination during adolescence can prevent HPV-associated cervical cancers, yet less than half of adolescent girls are vaccinated. This study examined the association between HPV knowledge and parental intentions to vaccinate daughters against HPV. A retrospective, cross-sectional, national data set from the 2006-2007 Health Information National Trends Survey (HINTS) was used. A multivariate multinomial logistic regression analysis was used to estimate the association between intent to vaccinate and HPV knowledge...
December 1, 2016: Western Journal of Nursing Research
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