keyword
https://read.qxmd.com/read/38521515/menace-of-hepatitis-e-in-pregnancy-unleashing-the-threat-of-fulminant-liver-failure
#1
JOURNAL ARTICLE
Tanisha Gupta, Soniya Dhiman, Aparna Sharma
This case report presents a primigravida in her 20s with a history of seizure disorder and chronic cholecystitis, who presented at 30 weeks and 6 days of gestation with upper abdominal pain, fever and vomiting. Initially diagnosed with acute calculous cholecystitis, the patient's condition rapidly deteriorated, resulting in fetal demise and the development of severe complications. Subsequent investigations revealed an enlarged fatty liver and signs of acute liver failure. The diagnosis of acute fatty liver of pregnancy was initially considered but later ruled out, and the patient was diagnosed with hepatitis E based on positive anti-hepatitis E virus IgM antibodies...
March 22, 2024: BMJ Case Reports
https://read.qxmd.com/read/38487350/acute-fatty-liver-disease-of-pregnancy
#2
REVIEW
Mary White, Hannah Han, Vandana Khungar
No abstract text is available yet for this article.
2024: Clinical Liver Disease
https://read.qxmd.com/read/38473993/embryonic-amoxicillin-exposure-has-limited-impact-on-liver-development-but-increases-susceptibility-to-nafld-in-zebrafish-larvae
#3
JOURNAL ARTICLE
Peng Gao, Cheng Chang, Jieling Liang, Fen Du, Ruilin Zhang
Amoxicillin is commonly used in clinical settings to target bacterial infection and is frequently prescribed during pregnancy. Investigations into its developmental toxicity and effects on disease susceptibility are not comprehensive. Our present study examined the effects of embryonic amoxicillin exposure on liver development and function, especially the effects on susceptibility to non-alcoholic fatty liver disease (NAFLD) using zebrafish as an animal model. We discovered that embryonic amoxicillin exposure did not compromise liver development, nor did it induce liver toxicity...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465073/key-components-of-successful-management-of-acute-fatty-liver-of-pregnancy-a-case-report-and-literature-review
#4
Rekha Patidar, Krishi Gowdra Revannasiddappa, Muniza Ghazanfer
Acute fatty liver of pregnancy (AFLP) is a rare, potentially fatal obstetric emergency. Due to its nonspecific signs and symptoms, there is often a delay in diagnosis and management which is associated with morbid complications and high mortality. We report a case of a 30-year-old female gravida 3 para 2 at 32 weeks gestation who presented with nausea and vomiting for two weeks, pruritis for three days, and upper abdomen pain for a day. A clinical diagnosis of HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome/obstetric cholestasis/AFLP was made...
February 2024: Curēus
https://read.qxmd.com/read/38449848/dietary-nutrients-during-gestation-cause-obesity-and-related-metabolic-changes-by-altering-dna-methylation-in-the-offspring
#5
REVIEW
Szilvia Bokor, Ildikó Csölle, Regina Felső, Réka A Vass, Simone Funke, Tibor Ertl, Dénes Molnár
Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38439560/prenatal-prednisone-exposure-impacts-liver-development-and-function-in-fetal-mice-and-its-characteristics
#6
JOURNAL ARTICLE
Yongguo Dai, Yu Peng, Zhengjie Lu, Tongyun Mao, Kaiqi Chen, Xiaoqian Lu, Kexin Liu, Xinli Zhou, Wen Hu, Hui Wang
Prednisone, a widely used glucocorticoid drug in human and veterinary medicine, has been reported to cause developmental toxicity. However, systematic studies about the effect of prednisone on fetal liver development are still unclear. We investigated the potential effects of maternal exposure to clinically equivalent doses of prednisone during different gestational stages on cell proliferation and apoptosis, cell differentiation, glucose and lipid metabolism, and hematopoiesis in the liver of fetal mice, and explored the potential mechanisms...
March 4, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38433535/maternal-gestational-hypertension-smoking-and-pre-eclampsia-are-associated-with-metabolic-dysfunction-associated-fatty-liver-disease-in-overweight-offspring
#7
JOURNAL ARTICLE
Hanna de Ruyter, Linnea Aitokari, Siiri Lahti, Hanna Riekki, Heini Huhtala, Timo Lakka, Hannele Laivuori, Kalle Kurppa
INTRODUCTION: Due to a steep increase in obesity, metabolic dysfunction-associated fatty liver disease (MAFLD) has also become the most common chronic hepatic condition among children and adolescents. Various maternal and pregnancy-related factors have also been implicated in the development of MAFLD, but human studies remain scarce. MATERIAL AND METHODS: Comprehensive data of 460 overweight or obese children aged 2-16 years were collected and combined with data on selected maternal and pregnancy-related factors for a case-control study...
March 3, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38430181/resistant-dextrin-protects-rats-against-streptozotocin-induced-gestational-diabetes-mellitus-via-alteration-of-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#8
JOURNAL ARTICLE
Shuijing Wang, Liangkun Ma, Jing Ji, Ruichao Huo, San Dong, Yunfeng Bai, Linlin Hua, Yan Yu
OBJECTIVE: Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs in 3-5% of pregnancies. The inflammatory response is essential to the development of GDM. Resistant dextrin is a natural fiber and exhibits an antidiabetic effect against diabetes. We investigate resistant dextrin's preventive role and underlying mechanism against STZ-induced GDM. MATERIAL AND METHOD: Female Wistar rats were utilized, and GDM was induced in pregnant rats using STZ...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38411871/liver-imaging-and-pregnancy-what-to-expect-when-your-patient-is-expecting
#9
REVIEW
Giorgia Porrello, Roberto Cannella, Jacques Bernuau, Antoine Agman, Giuseppe Brancatelli, Marco Dioguardi Burgio, Valérie Vilgrain
Liver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, pre-eclampsia, eclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, and acute fatty liver of pregnancy; (2) liver diseases that are more frequent during or exacerbated by pregnancy: acute herpes simplex hepatitis, Budd-Chiari syndrome, hemorrhagic hereditary telangiectasia, hepatocellular adenoma, portal vein thrombosis, and cholelithiasis; (3) coincidental conditions, including acute hepatitis, incidental focal liver lesions, metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatocellular carcinoma, liver abscesses and parasitosis, and liver transplantation...
February 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38386674/determinants-of-non-alcoholic-fatty-liver-disease-in-young-people-maternal-neonatal-and-adolescent-factors
#10
JOURNAL ARTICLE
Johannes Nairz, Alex Messner, Sophia J Kiechl, Bernhard Winder, Christoph Hochmayr, Alexander E Egger, Andrea Griesmacher, Ralf Geiger, Elke Griesmaier, Raimund Pechlaner, Michael Knoflach, Ursula Kiechl-Kohlendorfer
AIM: To assess the impact of maternal, neonatal, and adolescent factors on the development of non-alcoholic fatty liver disease (NAFLD) in a cohort of 14- to 19-year-old adolescents. METHODS: This study is part of the Early Vascular Ageing in the YOUth study, a single-center cross-sectional study conducted in western Austria. Maternal and neonatal factors were extracted from the mother-child booklet, adolescent factors were evaluated by a face-to-face interview, physical examination, and fasting blood analyses...
2024: PloS One
https://read.qxmd.com/read/38367998/iron-overload-in-anaemia-with-underlying-haemoglobin-constant-spring-in-an-antenatal-mother-in-primary-care
#11
JOURNAL ARTICLE
Hui Zhu Thew, Chee Han Ng, Cheng Yee Loo
This is the case of a gravida 3 para 1 woman in her late 20s with underlying haemoglobin constant spring who visited a healthcare clinic for an antenatal check-up. Towards the end of her second trimester, she experienced lethargy. During her antenatal booking, she was diagnosed with mild asymptomatic anaemia, high serum ferritin, T saturation of 88% and abnormal liver function tests. She was referred to a hospital where an MRI scan revealed over 2 g of iron deposits in her liver, leading to a revised diagnosis of iron overload...
February 17, 2024: BMJ Case Reports
https://read.qxmd.com/read/38306985/a-multi-tissue-metabolome-atlas-of-primate-pregnancy
#12
JOURNAL ARTICLE
Dainan Yu, Haifeng Wan, Chao Tong, Lu Guang, Gang Chen, Jiali Su, Lan Zhang, Yue Wang, Zhenyu Xiao, Jinglei Zhai, Long Yan, Wenwu Ma, Kun Liang, Taoyan Liu, Yuefan Wang, Zehang Peng, Lanfang Luo, Ruoxuan Yu, Wei Li, Hongbo Qi, Hongmei Wang, Ng Shyh-Chang
Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this metabolic reprogramming remain poorly understood, especially in primates. Using cynomolgus monkeys, we constructed a comprehensive multi-tissue metabolome atlas, analyzing 273 samples from 23 maternal tissues during pregnancy. We discovered a decline in metabolic coupling between tissues as pregnancy progressed. Core metabolic pathways that were rewired during primate pregnancy included steroidogenesis, fatty acid metabolism, and arachidonic acid metabolism...
February 1, 2024: Cell
https://read.qxmd.com/read/38257153/a-narrative-review-on-maternal-choline-intake-and-liver-function-of-the-fetus-and-the-infant-implications-for-research-policy-and-practice
#13
REVIEW
Rima Obeid, Christiane Schön, Emma Derbyshire, Xinyin Jiang, Tiffany J Mellott, Jan Krzysztof Blusztajn, Steven H Zeisel
Dietary choline is needed to maintain normal health, including normal liver function in adults. Fatty liver induced by a choline-deficient diet has been consistently observed in human and animal studies. The effect of insufficient choline intake on hepatic fat accumulation is specific and reversible when choline is added to the diet. Choline requirements are higher in women during pregnancy and lactation than in young non-pregnant women. We reviewed the evidence on whether choline derived from the maternal diet is necessary for maintaining normal liver function in the fetus and breastfed infants...
January 15, 2024: Nutrients
https://read.qxmd.com/read/38256199/maternal-diet-high-in-linoleic-acid-alters-offspring-lipids-and-hepatic-regulators-of-lipid-metabolism-in-an-adolescent-rat-model
#14
JOURNAL ARTICLE
Nirajan Shrestha, Simone L Sleep, Olivia J Holland, Josif Vidimce, Andrew C Bulmer, James S M Cuffe, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats and hepatic function in adult rats in a sex-specific manner. We investigated the effects of an HLA diet on adolescent offspring hepatic lipids and hepatic lipid metabolism gene expression, and the ability of the postnatal diet to alter these effects. Female Wistar Kyoto rats were fed low LA (LLA; 1.44% energy from LA) or high LA (HLA; 6...
January 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38232526/imazalil-resulted-in-glucolipid-metabolism-disturbance-and-abnormal-m-6-a-rna-methylation-in-the-liver-of-dam-and-offspring-mice
#15
JOURNAL ARTICLE
Cuiyuan Jin, Caiyun Wang, Chen Zhang, Qi Ye, Yuanxiang Jin, Liyun Shi
As a fungicide with the characteristics of high effectiveness, internal absorption and broad spectrum, imazalil is widely used to prevent and treat in fruits and vegetables. Here, pregnant C57BL/6 mice were exposed to imazalil at dietary levels of 0, 0.025‰, and 0.25‰ through drinking water during pregnancy and lactation. We then analyzed the phenotype, metabolome, and expression of related genes and proteins in the livers of mice. There was a marked decrease in the body and liver weights of male offspring mice after maternal imazalil exposure, while this effect on the dam and female offspring was slight...
January 16, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38201940/maternal-weight-intervention-in-the-perinatal-period-improves-liver-health-in-the-offspring-of-mothers-with-obesity
#16
JOURNAL ARTICLE
Amanda R Purcell, Natassia Rodrigo, Qinghua Cao, Olivia Joseph, Anthony J Gill, Sonia Saad, Carol A Pollock, Sarah J Glastras
Early-life exposure to maternal obesity predisposes offspring to metabolic-associated fatty liver disease (MAFLD). This study aimed to determine if peripartum weight loss, either through dietary intervention or pharmacological intervention, improved adverse liver health outcomes in the offspring of mothers with obesity. C57Bl/6 dams were fed a chow diet or a high-fat diet (HFD) for 8 weeks. HFD-fed mice either continued HFD, transitioned to a chow diet, or were administered liraglutide for 4 weeks. Pregnancy was induced following a one-week washout of liraglutide during which all animals remained on their respective diets...
December 28, 2023: Nutrients
https://read.qxmd.com/read/38199723/in-utero-exposures-to-perfluoroalkyl-substances-and-the-human-fetal-liver-metabolome-in-scotland-a-cross-sectional-study
#17
JOURNAL ARTICLE
Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihovic, Antonia Schubert, Alex Douglas, David C Hay, Peter J O'Shaughnessy, John P Iredale, Sophie Shaw, Paul A Fowler, Matej Orešič
BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances are classed as endocrine disrupting compounds but continue to be used in many products such as firefighting foams, flame retardants, utensil coatings, and waterproofing of food packaging. Perfluoroalkyl exposure aberrantly modulates lipid, metabolite, and bile acid levels, increasing susceptibility to onset and severity of metabolic diseases, such as diabetes and metabolic dysfunction-associated steatotic liver disease. To date, most studies in humans have focused on perfluoroalkyl-exposure effects in adults...
January 2024: Lancet. Planetary Health
https://read.qxmd.com/read/38178044/factors-and-a-model-to-predict-three-month-mortality-in-patients-with-acute-fatty-liver-of-pregnancy-from-two-medical-centers
#18
JOURNAL ARTICLE
QiaoZhen Peng, TeXuan Zhu, JingRui Huang, YueLan Liu, Jian Huang, WeiShe Zhang
BACKGROUND: Acute fatty liver of pregnancy (AFLP) is an uncommon but potentially life-threatening complication. Lacking of prognostic factors and models renders prediction of outcomes difficult. This study aims to explore factors and develop a prognostic model to predict three-month mortality of AFLP. METHODS: This retrospective study included 78 consecutive patients fulfilling both clinical and laboratory criteria and Swansea criteria for diagnosis of AFLP. Univariate and multivariate cox regression analyses were used to identify predictive factors of mortality...
January 4, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38163761/maternal-and-neonatal-effects-of-maternal-oral-exposure-to-perfluoro-2-methoxyacetic-acid-pfmoaa-during-pregnancy-and-early-lactation-in-the-sprague-dawley-rat
#19
JOURNAL ARTICLE
Justin M Conley, Christy S Lambright, Nicola Evans, Jacqueline Bangma, Jermaine Ford, Donna Hill, Elizabeth Medlock-Kakaley, L Earl Gray
Perfluoro-2-methoxyacetic acid (PFMOAA) is a short-chain perfluoroalkyl ether carboxylic acid that has been detected at high concentrations (∼10 μg/L) in drinking water in eastern North Carolina, USA, and in human serum and breastmilk in China. Despite documented human exposure there are almost no toxicity data available to inform risk assessment of PFMOAA. Here we exposed pregnant Sprague-Dawley rats to a range of PFMOAA doses (10-450 mg/kg/d) via oral gavage from gestation day (GD) 8 to postnatal day (PND) 2 and compared results to those we previously reported for perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX)...
January 1, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38143808/two-deliveries-and-a-transplant-case-report-of-acute-fatty-liver-of-pregnancy-requiring-liver-transplant
#20
REVIEW
Taqwa Ahmed, Alexander Vogel, Thomas Owens, Farrah Naz Hussain, Mouyed Alawad, Swan Thung, Tatyana Kushner, Lauren T Grinspan
No abstract text is available yet for this article.
December 2023: Clinical Liver Disease
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