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https://www.readbyqxmd.com/read/27904178/topical-steroid-awareness-and-abuse-a-prospective-study-among-dermatology-outpatients
#1
T S Nagesh, A Akhilesh
BACKGROUND: Topical steroids are one of the most commonly abused drugs. There are only a few studies available which have highlighted the severity of this problem in India. However, these studies have concentrated mainly on the topical steroid abuse and its side effects over the face. AIMS: The aim of this study was to know the awareness among the people about various commonly available topical steroids and their combinations irrespective of usage and to know the extent of misuse of these drugs...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27885523/a-review-of-the-mechanism-of-action-of-lasers-and-photodynamic-therapy-for-onychomycosis
#2
REVIEW
Anil Kumar Bhatta, Uma Keyal, Xiuli Wang, Emese Gellén
Onychomycosis is one of the most common diseases in the field of dermatology. It refers to the fungal infection of the nail plate or nail bed with high incidence in the general population. The available treatment options for onychomycosis have limited use due to side effects, drug interactions, and contraindications, which necessitates the application of an alternative treatment for onychomycosis. In the recent years, lasers and photodynamic therapy (PDT) have been recognized as alternative treatment options...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27879085/potential-drug-drug-interactions-and-adverse-drug-reactions-in-dermatological-inpatients
#3
Lukas Koch, Birger Kränke, Werner Aberer
OBJECTIVES: To present information on the frequency of drug-drug interactions and adverse drug reactions, and to provide assistance on how to minimize these major problems in the pharmacological treatment of dermatological inpatients. PATIENTS AND METHODS: The medications given to 1,099 dermatological inpatients were retrospectively analyzed for drug-drug interactions and adverse drug reactions using web-based drug interaction software (Diagnosia(®) Check). RESULTS: We report an overall frequency of relevant drug-drug interactions of 51...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#4
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
November 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27874885/patient-reported-outcomes-of-azelaic-acid-foam-15-for-patients-with-papulopustular-rosacea-secondary-efficacy-results-from-a-randomized-controlled-double-blind-phase-3-trial
#5
Stephen Tyring, James A Solomon, Gerald Staedtler, Jason P Lott, Richard Nkulikiyinka, Kaweh Shakery
Patient-reported treatment outcomes are important for evaluating the impact of drug therapies on patient experience. A randomized, double-blind, vehicle-controlled, parallel-group, multicenter, phase 3 study was conducted in 961 participants to assess patient perception of efficacy, utility, and effect on quality of life (QOL) of an azelaic acid (AzA) 15% foam formulation for the treatment of papulopustular rosacea (PPR). Secondary end points included patient-reported global assessment of treatment response, global assessment of tolerability, and opinion on cosmetic acceptability and practicability of product use...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#6
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27868472/topical-and-systemic-antifungals-in-dermatology-practice
#7
Murat Durdu, Macit Ilkit, Yalda Tamadon, Ali Tolooe, Haleh Rafati, Seyedmojtaba Seyedmousavi
Dermatophytosis is generally defined as an infection of the hair, nails, or glabrous skin. These infections are caused by the keratinophilic fungi Trichophyton spp., Microsporum spp., and Epidermophyton, which have been recovered from both symptomatic and asymptomatic individuals. Although dermatophytosis is generally not a life-threatening condition, these types of infections are among the most common infections worldwide, and their incidence has continued to increase consistently in recent years. Area covered: This article provides an overview of the general characteristics of dermatophytes, including their taxonomy and epidemiology, as well as the different clinical forms and laboratory diagnostics of dermatophytosis...
November 19, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27859683/s2k-guideline-for-treatment-of-cutaneous-lupus-erythematosus
#8
Annegret Kuhn, Elisabeth Aberer, Zsuzsanna Bata-Csörgő, Marzia Caproni, Andreas Dreher, Camille Frances, Regine Gläser, Hans-Wilhelm Klötgen, Aysche Landmann, Branka Marinovic, Filippa Nyberg, Rodica Olteanu, Annamari Ranki, Jacek C Szepietowski, Beatrix Volc-Platzer
Cutaneous lupus erythematosus (CLE) is a rare inflammatory autoimmune disease with heterogeneous subtypes. To date, no therapeutic agents have been licensed specifically for patients with this disease entity and topical and systemic drugs are mostly used "off-label". The aim of the present guideline was to achieve a broad consensus on treatment strategies for patients with CLE by a European subcommittee, guided by the European Dermatology Forum (EDF) and supported by the European Academy of Dermatology and Venereology (EADV)...
November 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27859479/diverse-types-of-dermatologic-toxicities-from-immune-checkpoint-blockade-therapy
#9
REVIEW
Jonathan L Curry, Michael T Tetzlaff, Priyadharsini Nagarajan, Carol Drucker, Adi Diab, Sharon R Hymes, Madeleine Duvic, Wen-Jen Hwu, Jennifer A Wargo, Carlos A Torres-Cabala, Ronald P Rapini, Victor G Prieto
Immunomodulatory drugs that leverages host immune mechanisms to destroy tumor cells has been met with great promise in the treatment of cancer. Immunotherapy, targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have shown tremendous improvements in the survival of patients with advanced solid tumors. However, the development of dermatologic toxicity (DT) is a consequence to immunotherapy. Review of published reports of the DT to immunotherapy revealed patients receiving anti-CTCLA-4 antibody or anti-PD-1/PD-L1 antibody often develop a DT of any type and grade...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27855965/prescribing-practices-for-systemic-agents-in-the-treatment-of-severe-pediatric-atopic-dermatitis-in-the-us-and-canada-the-pedra-treat-survey
#10
Christine R Totri, Lawrence F Eichenfield, Kirsty Logan, Laura Proudfoot, Jochen Schmitt, Irene Lara-Corrales, Jeffrey Sugarman, Wynnis Tom, Elaine Siegfried, Kelly Cordoro, Amy S Paller, Carsten Flohr
BACKGROUND: There is a paucity of literature to direct physicians in the prescribing of immunomodulators for patients with severe atopic dermatitis (AD). OBJECTIVE: To survey systemic agent prescribing practices for severe childhood AD among clinicians in the United States and Canada. METHODS: The TREatment of severe Atopic dermatitis in children Taskforce (TREAT), US&CANADA, a project of the Pediatric Dermatology Research Alliance (PeDRA), developed an online multiple-response survey to assess clinical practice, gather demographic information and details of systemic agent selection, and identify barriers to their use in patients with recalcitrant pediatric AD...
November 14, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27846016/botanicals-in-dermatology-essential-oils-botanical-allergens-and-current-regulatory-practices
#11
Sarah Mortimer, Margo Reeder
Largely because of their perceived safety, the use of essential oils and other botanically derived products has become increasingly popular. Recent evidence raises concern about the safety of these products, frequently found in cosmetics and sought as an alternative to standard medical treatments. Essential oils are challenging to standardize because of the variable growing conditions, genetics, and harvesting of botanicals. There exists a potential for adverse reactions, in particular allergic contact dermatitis...
November 2016: Dermatitis
https://www.readbyqxmd.com/read/27845513/the-switching-from-a-biological-therapy-to-another-biologic-agent-in-psoriatic-patients-the-experience-of-psomarche-group
#12
Giulia Ganzetti, Anna Campanati, Alberta Bettacchi, Giuliano Brandozzi, Valerio Brisigotti, Leonardo Bugatti, Ivana Cataldi, Giorgio Filosa, Alfredo Giacchetti, Giuseppe Lemme, Lorenzo Morresi, Massimiliano Nicolini, Valentina Postacchini, Giuseppe Ricotti, Laura Rosa, Marco Simonacci, Annamaria Offidani
BACKGROUND: Switching is a "hot" topic and the main reasons for switching prior biologic agent are for a primary failure, a secondary failure or drug intolerance, patient's dissatisfaction, physician decision. The aim of the study was to assess the optimization of the switching from a biological to another. METHODS: Five Dermatological Units have participated to PsOMarche working group have studied thirty-eight patients affected moderate to severe chronic plaque psoriasis at time 0 (patient recruitment at time of switching from biological therapy to another), 8 weeks (T8), 16 weeks (T16)...
November 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27837194/lenalidomide-for-refractory-cutaneous-manifestations-of-pediatric-systemic-lupus-erythematosus
#13
E Y Wu, L E Schanberg, E C Wershba, C E Rabinovich
OBJECTIVE: Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. METHODS: We performed a retrospective chart review of 10 adolescents who received lenalidomide for recalcitrant cutaneous lupus erythematosus...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27836854/a-novel-spectroscopically-determined-pharmacodynamic-biomarker-for-skin-toxicity-in-cancer-patients-treated-with-targeted-agents
#14
Antoine Azan, Peter J Caspers, Tom C Bakker Schut, Séverine Roy, Céline Boutros, Christine Mateus, Emilie Routier, Benjamin Besse, David Planchard, Atmane Seck, Nyam Kamsu-Kom, Gorana Tomasic, Senada Koljenović, Vincent Noordhoek Hegt, Texier Matthieu, Emilie Lanoy, Alexander M Eggermont, Angelo Paci, Caroline Robert, Gerwin J Puppels, Lluis M Mir
Raman spectroscopy is a non-invasive and label-free optical technique that provides detailed information about the molecular composition of a sample. In this study, we evaluated the potential of Raman spectroscopy to predict skin toxicity due to tyrosine-kinase inhibitors treatment. We acquired Raman spectra of skin of patients undergoing treatment with MEK, EGFR or BRAF inhibitors which are known to induce severe skin toxicity; for this pilot study, three patients were included for each inhibitor. Our algorithm, based on Partial Least Squares-Discriminant Analysis (PLS-DA) and cross-validation by bootstrapping, discriminated to variable degrees spectra from patient suffering and not suffering cutaneous adverse events...
November 11, 2016: Cancer Research
https://www.readbyqxmd.com/read/27829672/management-of-psoriatic-arthritis-in-2016-a-comparison-of-eular-and-grappa-recommendations
#15
REVIEW
Laure Gossec, Laura C Coates, Maarten de Wit, Arthur Kavanaugh, Sofia Ramiro, Philip J Mease, Christopher T Ritchlin, Désirée van der Heijde, Josef S Smolen
Psoriatic arthritis (PsA) is a heterogeneous, potentially severe disease. Many therapeutic agents are now available for PsA, but treatment decisions are not always straightforward. To assist in this decision making, two sets of recommendations for the management of PsA were published in 2016 by international organizations - the European League Against Rheumatism (EULAR) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). In both sets of recommendations, the heterogeneity of PsA is recognized and the place of various drugs in the therapeutic armamentarium is discussed...
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27826400/the-prevalence-and-characteristics-of-performance-enhancing-drug-use-among-bodybuilding-athletes-in-the-south-of-iran-bushehr
#16
Mohammad Javad Haerinejad, Afshin Ostovar, Mohamad Reza Farzaneh, Mojtaba Keshavarz
BACKGROUND: Several reports have implied progressive increase of performance-enhancing drug (PED) use among Iranian athletes. More importantly, most of the previous research in the Iranian population had mainly focused on the anabolic steroid abuse, and ignored other agents. OBJECTIVES: The aim of this study was to investigate the prevalence and characteristics of PED use among bodybuilding athletes in Bushehr, south of Iran. METHODS: Four hundred and fifty three male bodybuilding athletes were recruited from Bushehr gyms between February and May of 2015...
September 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/27817126/treatment-with-ustekinumab-in-a-spanish-cohort-of-patients-with-psoriasis-and-psoriatic-arthritis-in-daily-clinical-practice
#17
Miriam Almirall, Jesús Rodriguez, Lourdes Mateo, José Manuel Carrascosa, Jaime Notario, Fernando Gallardo
After approval of the use of ustekinumab for treatment of moderate to severe psoriasis, patients with psoriatic arthritis have treated with this drug in daily clinical practice. The aims of this study were to describe baseline characteristics and evolution of a cohort of patients with psoriasis and psoriatic arthritis treated with ustekinumab and to compare differences between patients who discontinued treatment and those who maintained. A retrospective multicenter observational study including patients who had received ustekinumab for a minimum of 3 months from 2009 to 2015 was performed...
November 5, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27806490/therapeutic-effects-of-sansevieria-trifasciata-ointment-in-callosities-of-toes
#18
Hamidollah Afrasiabian, Reza Hododi, Mohammad Hadi Imanieh, Alireza Salehi
Currently study was a double-blind clinical trial in terms of ointments with different contents and the variables such as sex, drug charges, occupation, age, number of lesions, patients, lesions location, time of manifestation, lesion size and methods of treatment and recovery time. In addition, total patients under studied were 100 people in dermatology clinic of Farshchian hospital of Hamadan in Iran that they were divided into two groups. The first group (A) contained of 68 individual who were divided into three groups which used sanseveria extract with different percentage of containing 5, 10, and 20%...
July 21, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27799135/drug-induced-cutaneous-lupus-erythematosus-88-new-cases
#19
Rasa Laurinaviciene, Linda Holm Sandholdt, Anette Bygum
BACKGROUND: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time. OBJECTIVES: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor. MATERIALS & METHODS: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period...
October 31, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27788607/investigating-the-penetrating-potential-of-nanocomposite-%C3%AE-cycloethosomes-development-using-central-composite-design-in-vitro-and-ex-vivo-characterization
#20
Nida Akhtar, Anurag Verma, Kamla Pathak
CONTEXT: Atopic dermatitis (AD) is a chronic skin disease characterized by inflammation of the skin and has exhibited remarkable repercussions on human life across the globe. Fluocinolone acetonide (FA), a topical corticosteroid is employed in the treatment of atopic dermatitis, but suffers from limited penetration into deeper epidermis of atopic skin. OBJECTIVE: The present investigation was focused to explore the utility of β-cylcoethosomes in improvising the penetration deep into the skin...
November 16, 2016: Journal of Liposome Research
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