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https://www.readbyqxmd.com/read/29221649/-two-cases-of-granuloma-annulare-under-anti-pd1-therapy
#1
R Charollais, F Aubin, B Roche-Kubler, E Puzenat
BACKGROUND: Granuloma annulare as a granulomatous cutaneous reaction may be drug-induced. Immune checkpoint inhibitors including programmed death-1 (PD-1) inhibitors show remarkable antitumor activity and are approved for melanoma and other cancers. Different immune-related adverse effects have been described. We report herein a rare adverse effect of anti-PD1 therapy given for metastatic melanoma : granuloma annulare. PATIENTS AND METHODS: Two women receiving pembrolizumab metastatic melanoma presented with granuloma annulare...
December 5, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29220390/maldi-msi-of-melim-melanoma-searching-for-differences-in-protein-profiles
#2
Roman Guran, Lucie Vanickova, Vratislav Horak, Sona Krizkova, Petr Michalek, Zbynek Heger, Ondrej Zitka, Vojtech Adam
BACKGROUND: Treatment of advanced cutaneous melanoma remains challenging, and new data on melanoma biology are required. The most widely accepted criteria for the prognostic evaluation of melanoma are histopathological and clinical parameters, and the identification of additional tumor markers is thus of paramount importance. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI), an important tool in cancer research, is useful for unraveling the molecular profile of melanoma...
2017: PloS One
https://www.readbyqxmd.com/read/29218279/non-metastatic-non-melanoma-skin-cancers-our-3-years-of-clinical-experiences
#3
Elif Sari
BACKGROUND: Nonmelanoma skin cancers (NMSC) constitute the largest group of skin cancers. In this study, NMSCs were analyzed retrospectively. METHODS: Between June 2013 and March 2017, demographics and comorbidities of patients underwent reconstructive surgery for NMSC; their risk factors, types, diameters, differentiation, localizations, follow-up times, treatment methods and complications were compared and statistically analyzed. RESULTS: Totally, 163 tumors [111 basal cell carcinoma and 52 cutaneous squamous cell carcinoma (cSCC)] were excized from 148 patients (63 females, 85 males)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29215016/low-neurotrophin-receptor-cd271-regulates-phenotype-switching-in-melanoma
#4
Gaetana Restivo, Johanna Diener, Phil F Cheng, Gregor Kiowski, Mario Bonalli, Thomas Biedermann, Ernst Reichmann, Mitchell P Levesque, Reinhard Dummer, Lukas Sommer
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic capacity. According to the "phenotype switching" model, the aggressive nature of melanoma cells results from their intrinsic potential to dynamically switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state. Here we identify the low affinity neurotrophin receptor CD271 as a key effector of phenotype switching in melanoma. CD271 plays a dual role in this process by decreasing proliferation, while simultaneously promoting invasiveness...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29214867/disease-site-as-a-determinant-of-survival-outcome-in-patients-with-primary-cutaneous-peripheral-t-cell-lymphoma-unspecified-an-analysis-of-4057-cases-from-the-us-national-cancer-database
#5
Chang Su, Kevin A Nguyen, Harrison X Bai, Ya Cao, Yongguang Tao, Giorgos Karakousis, Paul J Zhang, Guiying Zhang, Rong Xiao
Primary cutaneous peripheral T-cell lymphoma, unspecified (PCPTL) accounts for <6% of cutaneous T-cell lymphoma cases. Due to its rarity, no large study exists in the literature on PCPTL. Among 4057 patients with PCPTL diagnosed from 2004 to 2014 in the National Cancer Database, 428, 913, 517, 754, and 1435 had lesions localized primarily to the upper extremity, head and neck, lower extremity, trunk, and overlapping lesion or unspecified site, respectively. PCPTL that primarily involved the head and neck had the longest overall survival (OS), followed by PCPTL that primarily involved the trunk, upper extremity, and lower extremity...
December 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29212084/perioperative-outcomes-and-early-survival-in-octogenarians-who-underwent-radical-cystectomy-for-bladder-cancer
#6
Fabio Zattoni, Vito Palumbo, Gianluca Giannarini, Alessandro Crestani, Afrovita Kungulli, Giacomo Novara, Filiberto Zattoni, Vincenzo Ficarra
OBJECTIVE: To evaluate perioperative outcomes and early survival in a series of octogenarians who underwent radical cystectomy (RC) and urinary diversion for bladder cancer. PATIENTS AND METHODS: We retrospectively evaluated the clinical records of 44 patients aged ≥80 years who underwent open RC and urinary diversion at 2 high-volume centers between July 2013 and December 2015. Estimated blood loss (EBL), transfusion rate, and length of hospital stay (LOS) were evaluated...
December 7, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29211697/cocaine-levamisole-associated-autoimmune-syndrome-a-disease-of-neutrophil-mediated-autoimmunity
#7
Michael J Cascio, Kuang-Yu Jen
PURPOSE OF REVIEW: Levamisole was previously used for its immunomodulatory properties to treat rheumatoid arthritis and some cancers. However, because of serious side-effects, it was taken off the market in the United States. Recently, levamisole has reemerged as a popular cocaine adulterant. Some individuals who consume levamisole-adulterated cocaine can develop a life-threatening autoimmune syndrome. In this review, the medical consequences of levamisole exposure and postulated mechanisms by which levamisole induces these adverse effects are discussed...
January 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29210005/the-novel-role-of-il-37-in-prostate-cancer-evidence-as-a-promising-radiosensitizer
#8
Vivi A Ding, Ziwen Zhu, Timothy A Steele, Mark R Wakefield, Huaping Xiao, Dean Balabanov, Yujiang Fang
Prostate cancer (PCa) is the most common non-cutaneous cancer in men in the USA. Radiation therapy (RT) is widely considered the standard treatment for PCa. IL-37 is an IL-1 family member, and it has been extensively studied in immunity. However, no studies have been done regarding its potential as a radiosensitizer. This study is designed to investigate the direct effect of IL-37 on growth of DU145 and PC-3, two widely studied PCa cell lines, and to investigate whether IL-37 could be used as a radiosensitizer for PCa...
December 5, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29209571/complete-regression-of-cutaneous-metastases-with-systemic-immune-response-in-a-patient-with-triple-negative-breast-cancer-receiving-p53mva-vaccine-with-pembrolizumab
#9
Yuan Yuan, Ferdynand J Kos, Ting-Fang He, Hongwei H Yin, Mengsha Li, Nicola Hardwick, Kathryn Zurcher, Daniel Schmolze, Peter Lee, Raju K Pillai, Vincent Chung, Don J Diamond
A heavily pretreated patient with triple negative breast cancer distinguished by cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her cutaneous metastases regressed and after 2 cycles of therapy, a skin biopsy showed a complete pathological response. Systemic response was confirmed with restaging CT and bone scans. Activation of p53-specific T cell responses and elevation of multiple immune response genes in peripheral blood correlated with the rapid clinical response which lasted for 6 months after the initiation of combined therapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29208932/mouse-papillomavirus-infection-persists-in-mucosal-tissues-of-an-immunocompetent-mouse-strain-and-progresses-to-cancer
#10
Nancy M Cladel, Lynn R Budgeon, Karla K Balogh, Timothy K Cooper, Sarah A Brendle, Neil D Christensen, Todd D Schell, Jiafen Hu
Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains. In the current study, we examined mucosal infection in several immunocompetent and immunocompromised mouse strains. Viral DNA was monitored periodically by Q-PCR of lavage samples. Immunohistochemistry and in situ hybridization were used to determine viral capsid protein and viral DNA respectively. All athymic nude mouse strains showed active infections at both cutaneous and mucosal sites...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29204254/gastric-metastasis-from-ovarian-adenocarcinoma-presenting-as-a-subepithelial-tumor-and-diagnosed-by-endoscopic-ultrasound-guided-tissue-acquisition
#11
Filippo Antonini, Liboria Laterza, Lorenzo Fuccio, Massimo Marcellini, Lucia Angelelli, Sonia Calcina, Corrado Rubini, Giampiero Macarri
We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor (SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy (EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features...
November 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29197843/carcinoma-en-cuirasse
#12
Angela Alani, Gerallt Roberts, Olga Kerr
We present a case of carcinoma en cuirasse as a presentation of advanced lobular breast carcinoma. On further investigation, she was found to have metastasis to her liver and bone. We report this case to highlight the phenomenon of cutaneous metastasis. It is important to consider this diagnosis as an initial manifestation of breast cancer, but rarely, it can also be associated with other adenocarcinomas, for example, carcinoma of lung, kidney or gastrointestinal tract.
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29197746/proton-therapy-for-locally-advanced-breast-cancer-a-systematic-review-of-the-literature
#13
REVIEW
Emmanuel Kammerer, Jennifer Le Guevelou, Abdulhamid Chaikh, Serge Danhier, Julien Geffrelot, Christelle Levy, Eric Saloux, Jean-Louis Habrand, Juliette Thariat
BACKGROUND: Radiation therapy plays a major role in the management of adjuvant breast cancer with nodal involvement, with an iatrogenic increase of cardio-vascular risk. Photon therapy, even with intensity modulation, has the downsides of high mean heart dose and heterogeneous target coverage, particularly in the case of internal mammary irradiation. This systematic review of the literature aims to evaluate proton therapy in locally advanced breast cancer. MATERIAL AND METHODS: PubMed was searched for original full-text articles with the following search terms: «Proton Therapy» and «Breast Cancer»...
November 24, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29194095/is-nonmetastatic-cutaneous-melanoma-predictable-through-genomic-biomarkers
#14
Mattia Branca, Samuel Orso, Roberto C Molinari, Haotian Xu, Stéphane Guerrier, Yuming Zhang, Nabil Mili
Cutaneous melanoma is a highly aggressive skin cancer whose treatment and prognosis are critically affected by the presence of metastasis. In this study, we address the following issue: which gene transcripts and what kind of interactions between them can allow to predict nonmetastatic from metastatic melanomas with a high level of accuracy? We carry out a meta-analysis on the first gene expression set of the Leeds melanoma cohort, as made available online on 11 May 2016 through the ArrayExpress platform with MicroArray Gene Expression number 4725...
November 29, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29190285/the-interplay-of-uv-and-cutaneous-papillomavirus-infection-in-skin-cancer-development
#15
Daniel Hasche, Sonja Stephan, Ilona Braspenning-Wesch, Julita Mikulec, Martina Niebler, Hermann-Josef Gröne, Christa Flechtenmacher, Baki Akgül, Frank Rösl, Sabrina E Vinzón
Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma skin cancer (NMSC) development, especially in association with UVB. Extensively studied transgenic mouse models failed to mimic all aspects of virus-host interactions starting from primary infection to the appearance of a tumor. Using the natural model Mastomys coucha, which reflects the human situation in many aspects, we provide the first evidence that only UVB and Mastomys natalensis papillomavirus (MnPV) infection strongly promote NMSC formation...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29186900/rodent-papillomaviruses
#16
REVIEW
Aayushi Uberoi, Paul F Lambert
Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which infects the Mastomys species of multimammate rats, and MmuPV1, which infects laboratory mice, are currently the most studied rodent PVs...
November 27, 2017: Viruses
https://www.readbyqxmd.com/read/29185769/a-drug-repurposing-approach-identifies-a-synergistic-drug-combination-of-an-antifungal-agent-and-an-experimental-organometallic-drug-for-melanoma-treatment
#17
Tina Riedel, Olivier Demaria, Olivier Zava, Ana Joncic, Michel Gilliet, Paul J Dyson
By screening a drug library comprising FDA approved compounds, we discovered a potent interaction between the antifungal agent Haloprogin and the experimental organometallic drug RAPTA-T, to synergistically induce cancer cell killing. The combination of these two small molecules, even at low doses, elicited an improved therapeutic response on tumor growth over either agent alone or the current treatment used in the clinic in the highly aggressive syngeneic B16F10 melanoma tumor model, where classical cytotoxic chemotherapeutic agents show little efficacy...
November 29, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29184882/cutaneous-metastasis-a-rare-phenomenon-of-colorectal-cancer
#18
Dan Yang Wang, Feng Ye, Jian Jiang Lin, Xiao Xu
Cutaneous metastases from colorectal cancer are extremely rare and generally appear several years after diagnosis or resection of the primary tumor. Although this phenomenon is uncommon, it is very important and often indicates a poor prognosis. We present a case of a 76-year-old female patient with multiple cutaneous metastatic nodules on the back, just 1 month after resection of rectal cancer. Unfortunately, the patient gave up the follow-up treatment due to her age and poor physical condition; she died 3 months later...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29178944/malignant-acanthosis-nigricans-an-early-diagnostic-clue-for-gastric-adenocarcinoma
#19
Qian Yu, Xiu-Li Li, Guo Ji, Yao Wang, Yu Gong, Hui Xu, Yu-Ling Shi
BACKGROUND: Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before. CASE PRESENTATION: Here, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-old man presented with hyperkeratotic eruption for 7 months. Physical examination revealed hyperkeratotic plaques on the face, dorsal skin of fingers and heels, and papillomatosis of buccal mucosa...
November 25, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29178501/in-vivo-reflectance-confocal-microscopy-image-interpretation-for-the-dermatopathologist
#20
REVIEW
Neda Shahriari, Jane M Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope
Reflectance confocal microscopy (RCM) is a technology utilized for bedside diagnosis of cutaneous pathology by non-invasive, in vivo, cellular-level imaging. With the recent establishment of reimbursement codes by the US Centers for Medicaid and Medicare Services (CMS), RCM is now likely to be employed by clinical dermatologists and impact decision making on skin cancer management. Dermatopathologists, therefore, would benefit from learning how to interpret RCM images and how RCM findings correlate with histopathological criteria of diagnosis...
November 27, 2017: Journal of Cutaneous Pathology
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