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https://www.readbyqxmd.com/read/29029040/herbacetin-suppresses-cutaneous-squamous-cell-carcinoma-and-melanoma-cell-growth-by-targeting-akt-and-odc
#1
Dong Joon Kim, Mee-Hyun Lee, KangDong Liu, Do Young Lim, Eunmiri Roh, Hanyong Chen, Sung-Hyun Kim, Jung-Hyun Shim, Myoung Ok Kim, Wenwen Li, Fayang Ma, Mangaladoss Fredimoses, Ann M Bode, Zigang Dong
Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as a dual V-akt murine thymoma viral oncogene homolog (AKT) and ornithine decarboxylase (ODC) inhibitor, and illustrated its anticancer effects in vitro and in vivo against cutaneous squamous cell carcinoma (SCC) and melanoma cell growth...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29027689/oral-mucosa-model-for-electrochemotherapy-treatment-of-dog-mouth-cancer-ex-vivo-in-silico-and-in-vivo-experiments
#2
Daniela O H Suzuki, José A Berkenbrock, Marisa J S Frederico, Fátima R M B Silva, Marcelo M M Rangel
Electrochemotherapy (EQT) is a local cancer treatment well established to cutaneous and subcutaneous tumors. Electric fields are applied to biological tissue in order to improve membrane permeability for cytotoxic drugs. This phenomenon is called electroporation or electropermeabilization. Studies have reported that tissue conductivity is electric field dependent. Electroporation numerical models of biological tissues are essential in treatment planning. Tumors of the mouth are very common in dogs. Inadequate EQT treatment of oral tumor may be caused by significant anatomic variations between dogs and tumor position...
October 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29020893/clinical-practice-guidelines-for-the-diagnosis-and-management-of-melanoma-melanomas-that-lack-classical-clinical-features
#3
Victoria J Mar, Alex J Chamberlain, John W Kelly, William K Murray, John F Thompson
A Cancer Council Australia multidisciplinary working group is currently revising and updating the 2008 evidence-based clinical practice guidelines for the management of cutaneous melanoma. While there have been many recent improvements in treatment options for metastatic melanoma, early diagnosis remains critical to reducing mortality from the disease. Improved awareness of the atypical presentations of this common malignancy is required to achieve this. A chapter of the new guidelines was therefore developed to aid recognition of atypical melanomas...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29019164/tuberculosis-of-the-breast-in-togo-a-series-of-28-presumed-cases
#4
T Darré, M Tchaou, B N'Timon, A A Patassi, A Aboubakari, L Sonhaye, A Bassowa, K Amegbor, G Napo-Koura
Our study aimed to describe the epidemiological, clinical and histological aspects of mammary tuberculosis in Togo. This is a descriptive cross-sectional study of breast tuberculosis for which the diagnosis was presumed on histological grounds in the pathology department (LAP) of the Lomé Tokoin university hospital from January 1995 to December 2016 (20 years). A total of 28 presumed cases of mammary tuberculosis were identified. There were 26 women and 2 men, with an average age of 34.2 ± 0.3 years. The clinical signs were nodule (84...
October 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/29018888/-non-melanoma-skin-cancer-pathogenesis-prevalence-and-prevention
#5
A Zink
Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. The most common of these, basal cell carcinoma, squamous cell carcinoma and actinic keratoses as carcinomas in situ, are increasingly called keratinocyte carcinoma. Today, the pathogenesis and risk factors of NMSC are relatively well understood, which has led to multiple treatment options, the recognition of NMSC as an occupational disease in Germany and a variety of prevention approaches...
October 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28994104/epidemiology-of-keratinocyte-carcinomas-after-organ-transplantation
#6
REVIEW
M M Madeleine, N S Patel, E I Plasmeijer, E A Engels, J N Bouwes Bavinck, A E Toland, A C Green
Keratinocyte carcinoma (KC) is the most common type of cancer among white populations, but it is even more common among solid organ transplant recipients (OTRs). The most frequent histological type of KC among OTRs is cutaneous squamous cell carcinoma (cSCC), followed by basal cell carcinoma, although the reverse is seen in the general population. Metastatic cSCCs are more frequent, and mortality is increased compared with immunocompetent populations. There is strong evidence that the risk of KC among OTRs rises with increasing time after transplantation and older age at transplantation, and that KC is enhanced in those with sun-damaged skin...
October 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28992669/-a-case-of-secondary-extramammary-paget-s-disease-aroundthe-cutaneous-stoma-after-radical-cystectomy
#7
Sohei Kanda, Kazutoshi Okubo, Takuya Hida, Jin Kono, Takeshi Takahashi, Kenji Mitsumori, Toshihide Shimada, Kazuo Nishimura
We present a case of secondary extramammary Paget's disease around the cutaneous ureterostomy stoma after radical cystectomy. An 85-year-old man with bacillus calmette-guérin refractory high-grade urothelial carcinoma underwent radical cystectomy and cutaneous ureterostomy construction. After right ureter cancer diagnosis, he underwent right nephroureterectomy 3 years after the cystectomy. He developed refractory dermatitis around the cutaneous stoma 1 year after the nephroureterectomy. Skin biopsy revealed secondary extramammary Paget's disease, cured by skin excision around the cutaneous stoma and skin grafting...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28992298/incidence-of-pneumocystis-jirovecii-and-adverse-events-associated-with-pneumocystis-prophylaxis-in-children-receiving-glucocorticoids
#8
Matthew L Basiaga, Michelle E Ross, Jeffrey S Gerber, Alexis Ogdie
Background: Antimicrobial prophylaxis is indicated to prevent Pneumocystis jirovecii pneumonia (PJP) in profoundly immunosuppressed children. The incidence of PJP infection in children with chronic glucocorticoid exposure is unknown, and PJP prophylaxis has been associated with adverse events. We hypothesized that PJP infection is rare in children without human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), cancer, or a transplant history who are using chronic glucocorticoids and that those exposed to PJP prophylaxis are more likely to experience a cutaneous hypersensitivity reaction or myelosuppression than unexposed patients...
July 13, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28990515/recent-advances-and-perspectives-in-liposomes-for-cutaneous-drug-delivery
#9
Amanda C Caritá, Josimar O Eloy, Marlus Chorilli, Robert J Lee, Gislaine Ricci Leonardi
The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. In this review, we aimed to discuss key aspects for the topical delivery by drug-loaded liposomes. Phospholipid type and phase transition temperature have been shown to affect liposomal topical delivery...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28989104/epidemiology-of-malignant-cutaneous-granular-cell-tumors-a-united-states-population-based-cohort-analysis-using-the-surveillance-epidemiology-and-end-results-seer-database
#10
Fatima N Mirza, Charles T Tuggle, Cheryl K Zogg, Humza N Mirza, Deepak Narayan
BACKGROUND: Malignant cutaneous granular cell tumors (mcGCT) are rare and associated with substantial morbidity and mortality. The literature includes single-institution studies. OBJECTIVE: To examine the incidence, secondary malignancies, treatment, overall survival (OS), and disease-specific survival (DSS) of patients with mcGCT. METHODS: A population-based cohort analysis was conducted in the Surveillance, Epidemiology, and End Results (SEER) database, 1973-2013, for patients diagnosed with mcGCT...
October 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28988380/tumor-infiltrating-immune-cells-as-potential-biomarkers-predicting-response-to-treatment-and-survival-in-patients-with-metastatic-melanoma-receiving-ipilimumab-therapy
#11
Tímea Balatoni, Anita Mohos, Eszter Papp, Tímea Sebestyén, Gabriella Liszkay, Judit Oláh, Anita Varga, Zsuzsanna Lengyel, Gabriella Emri, István Gaudi, Andrea Ladányi
Monoclonal antibodies targeting immune checkpoints are gaining ground in the treatment of melanoma and other cancers, and considerable effort is made to identify biomarkers predicting the efficacy of these therapies. Our retrospective study was performed on surgical tissue samples (52 lymph nodes and 34 cutaneous/subcutaneous metastases) from 30 patients with metastatic melanoma treated with ipilimumab. Using a panel of 11 antibodies against different immune cell types, intratumoral immune cell densities were determined and evaluated in relation to response to ipilimumab treatment and disease outcome...
October 7, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28987144/cancer-associated-fibroblasts-cafs-are-activated-in-cutaneous-basal-cell-carcinoma-and-in-the-peritumoural-skin
#12
Silje Haukali Omland, Erika Elgstrand Wettergren, Tobias Mourier, Anders Johannes Hansen, Maria Asplund, Sarah Mollerup, Robert Robert
BACKGROUND: Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) in the microenvironment are essential for tumour growth in a variety of neoplasms but their role in BCC is poorly understood. METHODS: Material included facial BCC and control skin from the peritumoural area and from the buttocks. With next-generation sequencing (NGS) we compared mRNA expression between BCC and peritumoural skin...
October 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28984303/analysis-of-clinically-relevant-somatic-mutations-in-high-risk-head-and-neck-cutaneous-squamous-cell-carcinoma
#13
Catherine Zilberg, Matthew Weicai Lee, Bing Yu, Bruce Ashford, Spiridoula Kraitsek, Marie Ranson, Kerwin Shannon, Mark Cowley, N Gopalakrishna Iyer, Carsten E Palme, Sydney Ch'ng, Tsu-Hui Hubert Low, Sandra O'Toole, Jonathan R Clark, Ruta Gupta
Cutaneous squamous cell carcinoma is the second most prevalent malignancy, most frequently occurring in the head and neck (head and neck cutaneous squamous cell carcinoma). Treatment of locally advanced or metastatic disease is associated with functional morbidity and disfigurement. Underlying genetic mechanisms are poorly understood. Targeted sequencing of 48 clinically relevant genes was performed on DNA extracted from formalin-fixed and paraffin-embedded high-risk primary head and neck cutaneous squamous cell carcinomas that remained non-metastatic at minimum follow-up of 24 months...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28983918/how-many-cancer-cases-and-deaths-are-potentially-preventable-estimates-for-australia-in-2013
#14
Louise F Wilson, Annika Antonsson, Adele C Green, Susan J Jordan, Bradley J Kendall, Christina M Nagle, Rachel E Neale, Catherine M Olsen, Penelope M Webb, David C Whiteman
Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent of deaths. Many cancers develop because of exposure to lifestyle and environmental factors that are potentially modifiable. We aimed to quantify the proportions and numbers of cancer deaths and cases in Australia in 2013 attributable to 20 modifiable factors in eight broad groupings that are established causes of cancer, namely: tobacco smoke (smoking and second-hand), dietary factors (low intake of fruit, non-starchy vegetables and dietary fibre; and high intake of red and processed meat), overweight/obesity, alcohol, physical inactivity, solar ultraviolet radiation, infections (seven agents), and reproductive factors (lack of breastfeeding, menopausal hormone therapy use, combined oral contraceptive use)...
October 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28983909/anthropometric-factors-and-cutaneous-melanoma-prospective-data-from-the-population-based-janus-cohort
#15
Jo S Stenehjem, Marit B Veierød, Lill Tove Nilsen, Reza Ghiasvand, Bjørn Johnsen, Tom K Grimsrud, Ronnie Babigumira, Judy R Rees, Trude E Robsahm
The aim of the present study was to prospectively examine risk of cutaneous melanoma (CM) according to measured anthropometric factors, adjusted for exposure to ultraviolet radiation (UVR), in a large population-based cohort in Norway. The Janus Cohort, including 292,851 Norwegians recruited 1972-2003, was linked to the Cancer Registry of Norway and followed for CM through 2014. Cox regression was used to estimate hazard ratios (HRs) of CM with 95% confidence intervals (CIs). Restricted cubic splines were incorporated into the Cox models to assess possible non-linear relationships...
October 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28980004/brentuximab-vedotin-for-patients-with-refractory-lymphomatoid-papulosis-an-analysis-of-phase-2-results
#16
Daniel J Lewis, Rakhshandra Talpur, Auris O Huen, Michael T Tetzlaff, Madeleine Duvic
Importance: Brentuximab vedotin is a monomethyl auristatin E-conjugated monoclonal antibody directed against CD30. It represents a potential treatment for the CD30+ lymphoproliferative disorder lymphomatoid papulosis (LyP), which currently has no approved treatment. Objective: To assess the efficacy and safety of brentuximab vedotin for the treatment of LyP. Design, Setting, and Participants: In this study conducted at The University of Texas MD Anderson Cancer Center from May 10, 2011, to March 31, 2017, a total of 12 patients with LyP received brentuximab vedotin...
October 4, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28977902/onc201-selectively-induces-apoptosis-in-cutaneous-t-cell-lymphoma-cells-via-activating-pro-apoptotic-integrated-stress-response-and-inactivating-jak-stat-and-nf-%C3%AE%C2%BAb-pathways
#17
Xiao Ni, Xiang Zhang, Cheng-Hui Hu, Timothy Langridge, Rohinton S Tarapore, Joshua E Allen, Wolfgang Oster, Madeleine Duvic
Cutaneous T-cell lymphomas (CTCLs) are extremely symptomatic and still incurable, and more effective and less toxic therapies are urgently needed. ONC201, an imipridone compound, has shown efficacy in pre-clinical studies in multiple advanced cancers. This study was to evaluate the anti-tumor activity of ONC201 on CTCL cells. The effect of ONC201 on the cell growth and apoptosis were evaluated in CTCL cell lines (n=8) and primary CD4(+) malignant T cells isolated from CTCL patients (n=5). ONC201 showed a time-dependent cell growth inhibition in all treated cell lines with a concentration range of 1...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976750/inhibition-of-mast-cell-mediated-allergic-responses-by-arctii-fructus-extracts-and-its-main-compound-arctigenin
#18
Ji-Ye Kee, Seung-Heon Hong
The Arctium lappa (Arctii Fructus) seed and its major active compound, arctigenin (ARC), are known to have anti-cancer, anti-obesity, anti-osteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and the associated mechanism have not been elucidated. Therefore, we attempted to investigate the anti-allergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and TNF-α in mast cells...
October 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28976087/noninvasive-diagnosis-in-dermatology
#19
Julia Welzel, Sandra Schuh
In addition to dermoscopy, there are other imaging and biophysical methods for the noninvasive diagnosis of skin lesions. Confocal laser microscopy allows for high-resolution imaging of the epidermis and upper dermis. It is particularly suitable in the differential diagnosis of melanocytic lesions. Optical coherence tomography (OCT) has a lower resolution compared to confocal laser microscopy but a greater depth of penetration. It is primarily used for imaging epithelial skin cancer, especially in the context of monitoring the effectiveness of nonsurgical therapies...
October 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28975891/local-immune-response-in-cutaneous-basal-cell-carcinoma
#20
Silje Haukali Omland
BCC is an immunogenic tumor highlighted by the increased risk in immunosuppressed individuals and the frequent occurrence of tumor infiltrating lymphocytes (TILs) in the tumor surroundings. Immunotherapy is evolving as a promising treatment strategy for several cancer types where topical immunostimulators are among the possibilities for superficial BCC. The overall aim of this thesis is to characterize the immunologic response upon BCC as well as characterizing the surrounding tumor stroma. The aim was achieved by the use of a variety of laboratory techniques; immunohistochemistry, immunoflourescence, qRT-PCR and NGS...
October 2017: Danish Medical Journal
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