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Cancer oncology radiotherapy

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https://www.readbyqxmd.com/read/29452269/progress-in-radiotherapy-for-regional-and-oligometastatic-disease-in-2017
#1
REVIEW
Suresh Senan, Chad G Rusthoven, Ben J Slotman, Shankar Siva
This review highlights key publications and abstracts in the field of radiation oncology for lung cancer in 2017, and attempts to place these in the context of developments for the broader thoracic oncology community.
February 13, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29446317/credentialing-of-radiotherapy-centres-in-australasia-for-trog-09-02-chisel-a-phase-iii-clinical-trial-on-stereotactic-ablative-body-radiotherapy-of-early-stage-lung-cancer
#2
Tomas Kron, Brent Chesson, Nicholas Hardcastle, Melissa Crain, Natalie Clements, Mark Burns, David Ball
OBJECTIVE: A randomised clinical trial comparing Stereotactic Ablative Body Radiotherapy (SABR) with conventional radiotherapy for early stage lung cancer has been conducted in Australia and New Zealand under the auspices of the TransTasman Radiation Oncology Group (NCT01014130). We report on the technical credentialing program as prerequisite for centres joining the trial. METHODS: Participating centres were asked to develop treatment plans for two test cases to assess their ability to create plans according to protocol...
February 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#3
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29445027/a-curative-intent-trimodality-approach-for-isolated-abdominal-nodal-metastases-in-metastatic-colorectal-cancer-update-of-a-single-institutional-experience
#4
Benny Johnson, Zhaohui Jin, Michael G Haddock, Christopher L Hallemeier, James A Martenson, Rory L Smoot, David W Larson, Eric J Dozois, David M Nagorney, Axel Grothey
BACKGROUND: The purpose of this study was to define survival rates in patients with isolated advanced abdominal nodal metastases secondary to colorectal cancer (CRC), treated with curative-intent trimodality therapy. MATERIALS AND METHODS: Sixty-five patients received trimodality therapy, defined as chemotherapy delivered with external beam radiotherapy (EBRT) followed by lymphadenectomy and intraoperative radiotherapy (IORT). Infusional 5-fluorouracil was the most common radiosensitizer used (63%, 41 patients)...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29444918/immunotherapy-a-new-standard-of-care-in-thoracic-malignancies-a-summary-of-the-european-respiratory-society-research-seminar-of-the-thoracic-oncology-assembly
#5
Adrien Costantini, Marta Grynovska, Francesca Lucibello, Jorge Moisés, Franck Pagès, Ming S Tsao, Frances A Shepherd, Hasna Bouchaab, Marina Garassino, Joachim G J V Aerts, Julien Mazières, Michele Mondini, Thierry Berghmans, Anne-Pascale Meert, Jacques Cadranel
In May 2017, the second European Respiratory Society research seminar of the Thoracic Oncology Assembly entitled "Immunotherapy, a new standard of care in thoracic malignancies?" was held in Paris, France. This seminar provided an opportunity to review the basis of antitumour immunity and to explain how immune checkpoint inhibitors (ICIs) work. The main therapeutic trials that have resulted in marketing authorisations for use of ICIs in lung cancer were reported. A particular focus was on the toxicity of these new molecules in relation to their immune-related adverse events...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29436307/cancers-of-the-major-salivary-gland
#6
Eugene Son, Aru Panwar, Charles H Mosher, Daniel Lydiatt
Salivary gland malignancies are rare tumors that comprise multiple histologic entities with diverse clinical behavior. Mucoepidermoid carcinoma is the most frequent primary salivary malignancy, followed by adenoid cystic and acinic cell carcinoma. Although most salivary malignancies are asymptomatic, presentation with a rapidly enlarging mass may be accompanied by pain, functional neurologic deficits, soft-tissue invasion, or nodal enlargement. Assessment of clinical behavior and physical exam greatly contributes to diagnostic workup...
February 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29435872/a-phase-ii-trial-of-concurrent-chemoradiotherapy-with-weekly-paclitaxel-and-carboplatin-in-advanced-oesophageal-carcinoma
#7
Kuai-Le Zhao, Yi Xia, Yun-Hai Li, Yun Chen, Qi Liu, Jun-Hua Zhang, Jia-Ying Deng, Ta-Shan Ai, Han-Ting Zhu, Harun Badakhshi
BACKGROUND: This study was performed to assess the efficacy and feasibility of definitive chemoradiotherapy consisting of weekly doses of combined paclitaxel and carboplatin concurrent with radiation therapy, followed by 2 cycles of consolidation chemotherapy for advanced esophageal carcinoma. METHODS: Eligibility criteria included local, advanced, newly diagnosed and postoperative local regional lymph node metastasis; Eastern Cooperative Oncology Group (ECOG) score ≤ 2; and adequate organ function...
February 12, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29435742/information-needs-expressed-during-patient-oriented-oncology-consultations-quantity-variation-and-barriers
#8
Anesa Ahamad, Paul Wallner, Sharon Salenius, Rudi Ross, Eduardo Fernandez
High-quality oncology consultation includes patient-oriented communication tailored to patients' individualized needs. Common methods used in studies to increase question-asking are prompt lists and coaching pre-consultations. However, our patients were encouraged to ask questions by the physician during their visit. We aimed to estimate the quantity, nature, and variation of their questions when they were invited to ask by their oncologist. During radiotherapy consultations from 2012 to 2016, patient's questions were deliberately elicited and physician-transcribed...
February 12, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29435699/psychosocial-benefits-of-fertility-preservation-for-young-cancer-patients
#9
Juliana Assi, Juliana Santos, Tatiana Bonetti, Paulo C Serafini, Eduardo L A Motta, Mauricio Barbour Chehin
PURPOSE: The risk of ovarian failure after radiotherapy and/or chemotherapy is a concern among oncologic women. There is no doubt regarding the psycho-emotional benefits of fertility preservation (FP) after a cancer diagnosis because concerns about biological conception are a source of anxiety and can even affect the patient's cancer recovery. The aim of this study was to evaluate oncology patients' feelings, concerns, and life quality impacts related to FP. METHODS: This qualitative cross-sectional study was based on a questionnaire administered to a selected group of women diagnosed with cancer who underwent FP...
February 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29435293/a-case-of-peritoneal-malignant-mesothelioma-following-radiation-therapy-for-cervical-cancer
#10
Mitsutake Yano, Yuji Ikeda, Tomomi Kato, Mika Sakaki, Sho Sato, Akira Yabuno, Eito Kozawa, Masanori Yasuda
The present study presents a case of peritoneal malignant mesothelioma (PMM) following radiation therapy for cervical cancer. A 34-year-old Japanese woman, without asbestos exposure, was referred to the Department of Gynecologic Oncology, Saitama Medical University International Medical Center due to a cervical mass, and was diagnosed with cervical squamous cell carcinoma (SCC). The serum levels of tumor markers, including SCC antigen and cancer antigen 125 (CA125) were 229.0 ng/ml and 54.4 U/ml, respectively...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29429963/impact-of-comorbidity-on-tolerability-and-survival-following-curative-intent-intensity-modulated-radiotherapy-in-older-patients-with-nasopharyngeal-cancer
#11
Kiattisa Sommat, Nelson Ling Fung Yit, Fuqiang Wang, John Heng Chi Lim
OBJECTIVE: This study aimed to evaluate the predictive factors for survival and acute toxicities in older patients with NPC treated with curative intent IMRT. MATERIALS AND METHODS: Older patients aged 65 years and above with non-metastatic NPC treated with curative intent IMRT between 2003 and 2013 were retrospectively analysed. Variables examined were gender, age, overall stage, chemotherapy use, Eastern Cooperative Oncology Group (ECOG) performance status and comorbidity...
February 9, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29427749/long-term-functional-and-oncological-results-after-sphincter-saving-resection-for-rectal-cancer-cohort-study
#12
Bogdan Badic, Aurélien Joumond, Jérémie Thereaux, Charles Henry Gancel, Jean Pierre Bail
PURPOSE: The treatment of rectal cancer could be complex and the long term complications have the potential to greatly impact the quality of life. The aim of this study was to evaluate the long term functional and oncological results after sphincter-saving resection for rectal cancer. METHODS: Between January 2005 and December 2013, a total of 187 rectal resections with total mesorectal excision (TME) for cancer were performed. The data of 72 (38.5%) patients were available for analysis...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29427390/prevention-of-acute-radiodermatitis-by-photobiomodulation-a-randomized-placebo-controlled-trial-in-breast-cancer-patients-transdermis-trial
#13
Jolien Robijns, Sandrine Censabella, Stefan Claes, Luc Pannekoeke, Lore Bussé, Dora Colson, Iris Kaminski, Paul Bulens, Annelies Maes, Leen Noé, Marc Brosens, An Timmermans, Ivo Lambrichts, Veerle Somers, Jeroen Mebis
OBJECTIVE: Acute radiodermatitis (RD) is a distressing and painful skin reaction that occurs in 95% of the patients undergoing radiotherapy (RT). The aim of this study was to evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention of acute RD in breast cancer (BC) patients undergoing RT. METHODS: This study was a randomized, placebo-controlled trial including 120 BC patients that underwent an identical RT regimen post-lumpectomy. Patients were randomly assigned to the laser therapy (LT) or placebo group, with 60 patients in each group...
February 10, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29426746/image-guided-adaptive-brachytherapy-in-primary-vaginal-cancers-a-monocentric-experience
#14
Andres Huertas, Isabelle Dumas, Alexandre Escande, Eleonor Rivin Del Campo, Tony Felefly, Charles-Henri Canova, Anne Tailleur, Sebastien Gouy, Enrica Bentivegna, Philippe Morice, Christine Haie-Meder, Cyrus Chargari, Renaud Mazeron
PURPOSE: Primary vaginal cancer is a rare disease for which treatment has been modeled based on cervical cancer. We report our experience in the use of image-guided adaptive brachytherapy (IGABT) in this indication. METHODS AND MATERIALS: Patients treated for vaginal cancer with a combination of external beam radiation therapy and IGABT were identified through electronic search. The Groupe Européen de Curiethérapie-European Society for Radiotherapy and Oncology recommendations for cervical cancer have been extrapolated with the definition of two clinical target volumes (CTVs) corresponding to the residual disease after external beam radiation therapy (CTV BT ), assessed from clinical and imaging findings, and the so-called CTV i , comprising the CTV BT with directional margins and at least the initial disease at diagnosis...
February 6, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29423682/locally-advanced-oral-squamous-cell-carcinoma-patients-treated-with-photobiomodulation-for-prevention-of-oral-mucositis-retrospective-outcomes-and-safety-analyses
#15
Thaís Bianca Brandão, Karina Morais-Faria, Ana Carolina Prado Ribeiro, César Rivera, João Victor Salvajoli, Marcio Ajudarte Lopes, Joel B Epstein, Praveen R Arany, Gilberto de Castro, Cesar Augusto Migliorati, Alan Roger Santos-Silva
PURPOSE: The well-established clinical efficacy of photobiomodulation (PBM) therapy in management of oral mucositis (OM) is leading to increasing use in oncology care. This protection and enhanced repair of damage to mucosal tissue have led to the question of the potential effects of PBM therapy on pre-malignant and malignant cells. The purpose of this study was to examine the outcome of cancer therapy and incidence of tumor recurrence in locally advanced oral squamous cell carcinoma (OSCC) patients treated with PBM therapy for OM...
February 8, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29420985/role-of-prostate-mr-imaging-in-radiation-oncology
#16
REVIEW
Cynthia Ménard, Eric Paulson, Tufve Nyholm, Patrick McLaughlin, Gary Liney, Piet Dirix, Uulke A van der Heide
The use of prostate MR imaging in radiotherapy continues to evolve. This article describes its current application in the selection of treatment regimens, integration in treatment planning or simulation, and assessment of response. An expert consensus statement from the annual MR in RT symposium is presented, as a list of 21 key quality indicators for the practice of MR imaging simulation in prostate cancer. Although imaging requirements generally follow PIRADSv2 guidelines, additional requirements specific to radiotherapy planning are described...
March 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29419331/-icorg-05-03-prospective-randomized-non-inferiority-phase-iii-trial-comparing-two-radiation-schedules-in-malignant-spinal-cord-compression-not-proceeding-with-surgical-decompression-the-quality-of-life-analysis
#17
K A Lee, M Dunne, C Small, P J Kelly, O McArdle, J O'Sullivan, D Hacking, M Pomeroy, J Armstrong, M Moriarty, A Clayton-Lea, I Parker, C D Collins, P Thirion
BACKGROUND: The optimal primary external beam radiation therapy (EBRT) radiation schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. The ICORG 05-03 trial assessed if a 10 Gy single fraction radiation schedule was not inferior to one with 20 Gray (Gy) in five daily fractions, in terms of functional motor outcome, for the treatment of MSCC in patients not proceeding with surgical decompression. This article reports on two of the secondary endpoints, Quality of life (QoL), assessed according to the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) version 3...
February 8, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29412280/palliative-therapy-in-adults-with-cancer-a-cross-sectional-study
#18
Angelita Visentin, Maria de Fátima Mantovani, Luciana Puchalski Kalinke, Shirley Boller, Leila Maria Mansano Sarquis
OBJECTIVE: To characterize the socioeconomic and clinical profile of adult cancer patients in palliative therapy. METHOD: Cross-sectional study in an oncology hospital in Paraná, with 124 adult patients who started palliative therapy in the period from Jan. 2 to June 30, 2015. RESULTS: Of the participating population, 60.5% were women, 68.5% white, 48.4% married, 72.6% catholic and with income of one to two minimum wages. Non-smokers, 45...
March 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29409108/psychometric-evaluation-and-adaptation-of-the-spine-oncology-study-group-outcomes-questionnaire-to-evaluate-health-related-quality-of-life-in-patients-with-spinal-metastases
#19
Anne L Versteeg, Arjun Sahgal, Laurence D Rhines, Daniel M Sciubba, James M Schuster, Michael H Weber, Peter Pal Varga, Stefano Boriani, Chetan Bettegowda, Michael G Fehlings, Michelle J Clarke, Paul M Arnold, Ziya L Gokaslan, Charles G Fisher
BACKGROUND: The Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) was developed as the first spine oncology-specific health-related quality of life (HRQOL) measure. This study evaluated the psychometric properties and clinical validity of the SOSGOQ in a diverse cohort of patients with spinal metastases. METHODS: An international, multicenter, prospective observational cohort study including patients with spinal metastases who underwent surgery and/or radiotherapy was conducted by the AOSpine Knowledge Forum Tumor...
February 6, 2018: Cancer
https://www.readbyqxmd.com/read/29404305/profile-of-patients-undergoing-palliative-radiotherapy-a-single-institute-study-from-a-tertiary-care-oncology-center
#20
Virender Suhag, B S Sunita, Pankaj Vats, Nilotpal Chakravarty, Mayuri Jain, Rekha S Vashisht
Background: Palliative radiotherapy (PRT) plays a significant role in the palliation of symptoms in patients with cancer and constitutes nearly 50% of the workload in different settings. Aims: The aim is to study patient-, disease-, and treatment-related characteristics in locoregionally advanced and metastatic malignancies meriting palliative management. Setting and Design: This was a retrospective observational study in a tertiary care government institute with academic and research potential...
October 2017: South Asian Journal of Cancer
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