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Cancer oncology radiotherapy

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https://www.readbyqxmd.com/read/29029111/short-term-and-mid-term-survival-in-bronchial-sleeve-resection-by-robotic-system-versus-thoracotomy-for-centrally-located-lung-cancer
#1
Chang Gu, Xufeng Pan, Yong Chen, Jun Yang, Heng Zhao, Jianxin Shi
OBJECTIVES: The aim of this study was to compare the short-term and mid-term results of patients with centrally located lung cancer who underwent bronchial sleeve resection by robotic system or thoracotomy. METHODS: From September 2014 to September 2015, 103 patients, including 17 robotic and 86 open cases, were included in our study. All the clinicopathological data, operative details and follow-up information were investigated. RESULTS: There were no intraoperative deaths...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#2
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29028078/a-natural-pharma-standard-supplement-formulation-to-control-treatment-related-toxicity-and-oxidative-stress-in-genitourinary-cancer-a-preliminary-study
#3
A Ledda, G Belcaro, M Dugall, R Luzzi, M Hosoi, B Feragalli, R Cotellese, V Cosentino, M Cosentino, R Eggenhoffner, M Pellizzato, A Fratter, L Giacomelli
OBJECTIVE: Oncological treatments are associated with toxicities that may decrease compliance to treatment in most genitourinary cancer patients. Supplementation with pharmaceutical-standardized supplement may be a supplementary method to control the side effects after chemo- and radiotherapy and the increased oxidative stress associated to treatments. This registry study evaluated a natural combination of supplements containing curcumin, cordyceps, and astaxanthin (Oncotris™) used as supplementary management in genitourinary cancer patients who had undergone oncological therapy...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026789/the-impact-of-the-predictive-nursing-education-process-on-degree-of-comfort-and-quality-of-life-for-patients-in-the-oncology-department
#4
Yan Yu, Lijuan Hu, Xingu Chen, Mei Ge, Huijuan Zhu, Yusheng Yan
BACKGROUND: We investigated the application of a predictive nursing education process on the degree of comfort and quality of life for cancer patients. METHODS: A total of 168-cancer patient in Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China between June 2014 and June 2016 were enrolled and admitted for surgery or radiotherapy/chemotherapy treatment. Patients were randomly divided into control and observation groups, each containing 84 cases...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29025611/carbon-fiber-reinforced-intramedullary-nailing-in-musculoskeletal-tumor-surgery-a-national-multicentric-experience-of-the-italian-orthopaedic-society-siot-bone-metastasis-study-group
#5
Andrea Piccioli, Raimondo Piana, Michele Lisanti, Alberto Di Martino, Barbara Rossi, Francesco Camnasio, Marco Gatti, Pietro Maniscalco, Franco Gherlinzoni, Maria Silvia Spinelli, Davide Maria Donati, Roberto Biagini, Rodolfo Capanna, Vincenzo Denaro
INTRODUCTION: Carbon fiber reinforced (CFR) implants have been proposed for the treatment of fractures or impending fractures of the long bones in the oncology patient. Aim of this study is to present the largest cohort of oncology patients operated by CFR nailing by the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group. METHODS: 53 adult oncology patients were operated on with a CFR-PEEK nail. All the data from adjuvants therapies were collected. Bone callus formation, response to radiotherapy, relapse or progression of the osteolysis were recorded...
October 2017: Injury
https://www.readbyqxmd.com/read/29021972/evaluating-factors-for-prophylactic-feeding-tube-placement-in-gastroesophageal-cancer-patients-undergoing-chemoradiotherapy
#6
Vivek Verma, Pamela K Allen, Steven H Lin
PURPOSE: Though better studied in head/neck cancers, there are currently no studies on timing of feeding tube (FT) placement in patients with gastroesophageal cancer. This study sought to discern characteristics of patients who used versus did not use a prophylactic FT (pFT), and also analyzed factors associated with placement of FTs during chemoradiotherapy (CRT). METHODS/MATERIALS: From 1998 to 2013, 1,329 patients underwent neoadjuvant CRT, of which 323 received an FT...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29020683/combination-of-androgen-deprivation-therapy-and-salvage-radiotherapy-versus-salvage-radiotherapy-alone-for-recurrent-prostate-cancer-after-radical-prostatectomy
#7
Sangjun Yoo, Dalsan You, Young Seok Kim, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
INTRODUCTION: To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate cancer patients, we compared the oncologic outcomes between patients receiving RT + ADT and those receiving RT alone. MATERIALS AND METHODS: We reviewed the records of patients diagnosed with prostate cancer between 1995 and 2011, including 93 patients who underwent salvage RT and 69 patients who underwent salvage RT + ADT...
October 12, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29019951/chemotherapy-related-toxicity-nutritional-status-and-quality-of-life-in-precachectic-oncologic-patients-with-or-without-high-protein-nutritional-support-a-prospective-randomized-study
#8
Monika Ziętarska, Joanna Krawczyk-Lipiec, Leszek Kraj, Renata Zaucha, Sylwia Małgorzewicz
BACKGROUND: Cancer disease is usually associated with impaired nutritional status, which is one of the factors contributing to deterioration of the results of surgery, chemotherapy or radiotherapy. OBJECTIVES: The aim of the study was to determine whether nutritional support with high protein (ONS) in adult oncologic patients in the first step of cancer cachexia-asymptomatic precachexia, has an influence on the toxicity of systemic therapy. However, secondary endpoints were established: to determine whether high protein ONS influences the nutritional status, the quality of life, and the performance status...
October 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28993060/routine-bladder-cancer-treatment-dictates-divergence-from-trial-derived-regimens-results-of-treatment-at-44-radiotherapy-centers
#9
Anesa Ahamad, Alvaro Martinez, Sharon Salenius, Rudi Ross, Jason Efstathiou, Eduardo Fernandez
PURPOSE: To assess characteristics and outcome of patients treated with radiotherapy for muscle-invasive bladder cancer at 44 community-based radiotherapy centers and compare these to those on clinical trials. MATERIALS AND METHODS: We reviewed 155 patients who had been treated from 2010 to 2014. Overall survival and progression-free survival were estimated using the Kaplan-Meier method. Results were compared to a pooled analysis of 6 Radiation Therapy Oncology Group (RTOG) protocols...
October 6, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28988618/hospital-burden-of-long-term-genitourinary-and-gastrointestinal-toxicity-after-radical-radiotherapy-for-prostate-cancer
#10
Elaine J Redmond, Katelyn S Dolbec, Aisling S Fawaz, Hugh D Flood, Subhasis K Giri
INTRODUCTION: Treatment options for prostate cancer (PCa) include radical radiotherapy (RT) and radical prostatectomy, both of which have comparable oncological outcomes. The aim of this study was to investigate the hospital burden of long-term genitourinary and gastrointestinal toxicity among patients with PCa who were treated with radiotherapy at our institution. METHODS: The radiotherapy department database was used retrospectively to identify all patients who underwent radiotherapy for PCa from January 2006 to January 2008...
October 4, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28984492/prognostic-factors-affecting-survival-after-whole-brain-radiotherapy-in-patients-with-brain-metastasized-lung-cancer
#11
Georgios Tsakonas, Fatou Hellman, Michael Gubanski, Signe Friesland, Salomon Tendler, Rolf Lewensohn, Simon Ekman, Luigi de Petris
BACKGROUND: Whole-brain radiotherapy (WBRT) has been the standard of care for multiple NSCLC brain metastases but due to its toxicity and lack of survival benefit, its use in the palliative setting is being questioned. PATIENT AND METHODS: This was a single institution cohort study including brain metastasized lung cancer patients who received WBRT at Karolinska University Hospital. Information about Recursive Partitioning Analysis (RPA) and Graded Prognostic Assessment (GPA) scores, demographics, histopathological results and received oncological therapy were collected...
October 6, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28984132/evaluating-single-cell-dna-damage-induced-by-enhanced-radiation-on-gold-nanofilm-patch
#12
Yong Qiao, Yuanshuai Zhou, Tongqian Xiao, Zhiwei Zhang, Liyuan Ma, Ming Su, Guangli Suo
Although radiotherapy is a general oncology treatment and often synergistically applied with surgery and chemotherapy, it can cause side effect during and after treatment. Gold nanoparticle was studied as a potential material to enhance radiation to induce damage in cancer cells. But few studies are conducted to examine the effects of gold nanofilm on cell impairment under X-ray treatment. This paper described a micro-fabrication based single cell array platform to evaluate DNA damage induced by enhanced X-ray radiation on gold nanofilm patches (GNFPes)...
October 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28983643/-radical-prostatectomy-in-locally-advanced-prostate-cancer
#13
REVIEW
P Mandel, D Tilki, M Graefen
BACKGROUND: Due to an inverse stage migration, the proportion of patients with more aggressive and locally advanced prostate cancer (PCa) has increased over the last few years. The natural history in these patients shows a higher risk of local complications and worse oncologic outcome. OBJECTIVES: To analyze the impact of radical prostatectomy (RP) in patients with locally advanced PCa. MATERIALS AND METHODS: A review of the literature was performed using PubMed and MEDLINE databases focusing on articles addressing locally advanced PCa...
October 5, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28983442/minimal-rectal-toxicity-in-the-setting-of-comorbid-crohn-s-disease-following-prostate-cancer-radiotherapy-with-a-hydrogel-rectal-spacer
#14
Raj Singh, Philip S Jackson, Mollie Blake, James Cutlip, Sanjeev Sharma
We present one of the first cases of a prostate cancer (PCa) patient with inflammatory bowel disease (IBD) treated with intensity-modulated radiotherapy (IMRT) and a hydrogel rectal spacer. A 73-year-old male with a past medical history significant for Crohn's disease (CD) and the recent diagnosis of T1cN0M0 high-risk PCa was referred for definitive radiotherapy. Given the patient's history of CD and the possible increased risk of gastrointestinal (GI) toxicity and disease exacerbation, prior to IMRT, a hydrogel spacer was placed between the prostate and the anterior rectal wall to further minimize irradiation to the rectum...
August 1, 2017: Curēus
https://www.readbyqxmd.com/read/28978174/comparison-of-outcomes-between-trimodal-therapy-and-radical-cystectomy-in-muscle-invasive-bladder-cancer-a-propensity-score-matching-analysis
#15
Yeon Joo Kim, Sang Jun Byun, Hanjong Ahn, Choung-Soo Kim, Beom-Sik Hong, Sangjun Yoo, Jae-Lyun Lee, Young Seok Kim
Although radical cystectomy (RC) is considered as the standard therapy for muscle-invasive bladder cancer (MIBC), trimodal therapy (TMT) combining transurethral resection of the tumor with radiotherapy and chemotherapy is increasingly recommended as an alternative approach for bladder preservation. In the absence of randomized trials, we compared the clinical outcomes between RC and TMT using propensity score matching with 50 patients in the RC arm and 29 patients in the TMT arm. With respective median follow-up periods of 23 and 32 months for the RC and TMT groups, 5-year distant metastasis-free survival (58% vs...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978126/socioeconomic-deprivation-worsens-the-outcomes-of-italian-women-with-hormone-receptor-positive-breast-cancer-and-decreases-the-possibility-of-receiving-standard-care
#16
Francesca Di Salvo, Nicola Caranci, Teresa Spadea, Nicolas Zengarini, Pamela Minicozzi, Hade Amash, Mario Fusco, Fabrizio Stracci, Fabio Falcini, Claudia Cirilli, Giuseppina Candela, Rosanna Cusimano, Rosario Tumino, Milena Sant
BACKGROUND: Socioeconomic factors influence access to cancer care and survival. This study investigated the role of socioeconomic status on the risk of breast cancer recurrence and on the delivery of appropriate cancer care (sentinel lymph node biopsy and breast-conserving surgery plus radiotherapy), by patients' age and hormone receptor status. METHODS: 3,462 breast cancer cases diagnosed in 2003-2005 were selected from 7 Italian cancer registries and assigned to a socioeconomic tertile on the basis of the deprivation index of their census tract...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975081/radiotherapy-for-oligometastatic-lung-cancer
#17
REVIEW
Derek P Bergsma, Joseph K Salama, Deepinder P Singh, Steven J Chmura, Michael T Milano
Non-small cell lung cancer (NSCLC) typically presents at an advanced stage, which is often felt to be incurable, and such patients are usually treated with a palliative approach. Accumulating retrospective and prospective clinical evidence, including a recently completed randomized trial, support the existence of an oligometastatic disease state wherein select individuals with advanced NSCLC may experience historically unprecedented prolonged survival with aggressive local treatments, consisting of radiotherapy and/or surgery, to limited sites of metastatic disease...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28974857/a-phantom-study-on-fetal-dose-reducing-factors-in-pregnant-patients-with-breast-cancer-during-radiotherapy-treatment
#18
Akın Öğretici, Aydın Çakır, Uğur Akbaş, Canan Köksal, Ümmühan Kalafat, Makbule Tambaş, Hatice Bilge
PURPOSE: This study aims to investigate the factors that reduce fetal dose in pregnant patients with breast cancer throughout their radiation treatment. Two main factors in a standard radiation oncology center are considered as the treatment planning systems (TPSs) and simple shielding for intensity modulated radiation therapy technique. MATERIALS AND METHODS: TPS factor was evaluated with two different planning algorithms: Anisotropic analytical algorithm and Acuros XB (external beam)...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28972833/management-of-patients-with-stage-i-lung-cancer
#19
Jeffrey A Bogart, Jason Wallen
The treatment of stage I non-small-cell lung cancer has advanced markedly over the past century. The transition from therapeutic nihilism with ensured mortality to radical surgery with pneumonectomy to rational oncologic-based resection has resulted in dramatically improved outcomes and reduced morbidity. The superiority of anatomic resection with lobectomy over sublobar resection for fit patients with stage I disease, where more than one half of all patients should expect to be cured, is backed by level 1 evidence...
February 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28970853/development-of-a-nomogram-to-predict-n2-or-n3-stage-in-t1-2-invasive-breast-cancer-patients-with-no-palpable-lymphadenopathy
#20
Isaac Kim, Jai Min Ryu, Jai Myeong Kim, Hee Jun Choi, Se Kyung Lee, Jong Hwan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam
PURPOSE: Subsequent to the American College of Surgeons Oncology Group (ACOSOG) Z0011 and After Mapping of the Axilla: Radiotherapy or Surgery (AMAROS) trials, complete axillary lymph node dissection is not routinely performed, even in cases where metastatic sentinel lymph nodes are detected. We investigated the percentage of N2 or N3 stages in T1-2 invasive breast cancer patients with no lymphadenopathy and developed a nomogram to predict the possibility of N2 or N3 stages in these patients...
September 2017: Journal of Breast Cancer
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