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https://www.readbyqxmd.com/read/29665123/pilot-study-on-the-correlation-between-dermoscopic-patterns-and-fluorescence-in-situ-hybridization-findings-using-whole-slide-digital-imaging-for-acral-volar-melanocytic-lesions
#1
Dai Ogata, Eiichi Arai, Yoshiya Goto, Tetsuya Tsuchida
Dermoscopic evaluation of acral volar skin is helpful in differentiating malignant melanomas (MM) from benign melanocytic nevi. However, histological diagnosis remains difficult because sufficient evidence of histopathological changes to establish a diagnosis of MM are not easily obtained. The aim of the present study was to evaluate the effective use of fluorescence in situ hybridization (FISH) in the diagnosis of acral volar melanocytic lesions, and to determine whether acral volar melanocytic lesions show characteristic molecular biological features of malignant melanoma via FISH...
April 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29660787/high-gtse1-expression-promotes-acral-melanoma-progression-and-correlates-with-poor-clinical-prognosis
#2
Tianxiao Xu, Meng Ma, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Jie Dai, Sifan Yu, Junya Yan, Huan Yu, Xiaowen Wu, Huan Tang, Jiayi Yu, Yan Kong, Jun Guo
G-2 and S-phase expressed 1 (GTSE1) regulates cell cycle progression in human cancers. However, its significance and mechanism of action in acral melanoma (AM) remain unknown. In this study, we found that GTSE1 expression was upregulated in advanced stage/metastatic AM tissues and metastatic cell lines, and correlated with higher stage (P = 0.028) and poor disease-free survival (DFS) in patients with AM (P = 0.003). Cox regression assays validated GTSE1 expression to be an independent prognostic factor of DFS for patients with AM (P = 0...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29622385/necrolytic-acral-erythema-leading-to-diagnosis-of-chronic-hepatitis-c
#3
Garima Dabas, Sindhuja Tekumalla, Sanjeev Handa
No abstract text is available yet for this article.
March 12, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29606944/extensive-lepromatous-lymphadenitis-preceding-lesions-on-the-face-and-earlobes-an-unusual-presentation-of-leprosy-in-singapore
#4
Shi Yao Sam Yang, Wai Mun Sean Leong, Cruz Maria Teresa Kasunuran, Jing Xiang Huang, Sue-Ann Ju Ee Ho, Chen Wee Derrick Aw, Reshma A Merchant
Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries. In this case, the indurated lesions over the face demonstrated a preference for the outer lateral aspects over the maxillary areas, the nose bridge, and the pinna of the ears consistent with the organism's preference for cooler regions of the body...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29605863/increased-tenascin-c-and-dkk1-in-vitiligo-possible-role-of-fibroblasts-in-acral-and-non-acral-disease
#5
Samia M Esmat, Heba H El Hadidi, Rehab A Hegazy, Heba I Gawdat, Amira M Tawdy, Marwa M Fawzy, Dalia M AbdelHalim, Omnia S Sultan, Olfat G Shaker
Recently, multiple culprits-in addition to melanocytes-have been implicated in the pathogenesis of vitiligo. Among those factors are fibroblasts. However, their exact role has not been clearly elucidated. The aim of the study was to evaluate the possible role played by fibroblasts in vitiligo via studying the expression Tenascin C and DKK1 in acral versus non-acral vitiligo lesions. This case-control study included 19 non-segmental vitiligo patients and ten controls. All patients were subjected to thorough clinical evaluation...
March 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29600692/the-window-of-opportunities-for-targeted-therapy-in-brafwt-nraswt-kitwt-melanoma-biology-and-clinical-implications-of-fusion-proteins-and-other-mutations
#6
Marina Berger, Georg Richtig, Karl Kashofer, Ariane Aigelsreiter, Erika Richtig
Treatment options in advanced melanoma have been subject to a major change over the last years. The discovery of the oncogenic point mutation BRAFV600E and subsequently developed BRAF inhibitors had a major impact on patient's survival. Further important mutations have been found in the NRAS gene, although not yet druggable, and others involve c-kit in acral and mucosal melanoma. Imatinib was shown to achieve high response rates in c-kit mutated melanoma. Despite good response rates in these targeted therapies and introduction of immunotherapy, there are still patients left, who develop resistance upon therapy or patients without the option of targeted therapy...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29580550/correlation-between-clinical-histopathologic-and-ultrasound-findings-in-focal-acral-hyperkeratosis
#7
J Company-Quiroga, B Echeverría, J C Tardío, C Martínez-Morán
No abstract text is available yet for this article.
March 23, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29567352/mechanical-forces-in-skin-disorders
#8
REVIEW
Chao-Kai Hsu, Hsi-Hui Lin, Hans I-Chen Harn, Michael W Hughes, Ming-Jer Tang, Chao-Chun Yang
Mechanical forces are known to regulate homeostasis of the skin and play a role in the pathogenesis of skin diseases. The epidermis consists of keratinocytes that are tightly adhered to each other by cell junctions. Defects in keratins or desmosomal/hemidesmosomal proteins lead to the attenuation of mechanical strength and formation of intraepidermal blisters in the case of epidermolysis bullosa simplex. The dermis is rich in extracellular matrix, especially collagen, and provides the majority of tensile force in the skin...
March 8, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29559400/mycoplasma-pneumoniae-related-erythema-multiforme-clinical-and-histological-features-a-single-center-series-of-33-cases-compared-to-100-cases-induced-by-other-causes
#9
Reyhan Amode, Saskia Ingen-Housz-Oro, Nicolas Ortonne, Touda Bounfour, Sabine Pereyre, Frédéric Schlemmer, Emilie Bequignon, Gérard Royer, Pierre Wolkenstein, Olivier Chosidow
BACKGROUND: Mycoplasma pneumoniae (MP) infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of MP-related EM (MP-EM) have been poorly described in the literature. OBJECTIVE: To highlight differences between MP-EM and non-MP-EM. METHODS: This monocenter retrospective cohort study included all the patients admitted for EM from 2000 to 2015 in our dermatology department...
March 17, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29557620/-congenital-erythropoietic-porphyria-case-report-and-management-recommendations
#10
Claudia Salomone B, Isabel Ogueta C, Carlos Reyes V, Gloria Durán S, Noemí Aguirre, Angélica Wietstruck
Congenital erythropoietic porphyria is an extremely rare, autosomal recessive, non-acute cutaneous porphyria, caused by uroporphyrinogen III synthase deficiency, codificated by UROS gene on the chromosome 10q26.2. Porphyrins deposit in cornea, bones and teeth. The first symptoms could be manifested in early childhood, with skin fragility, vesicles and bullae. Severe course produces acral tissues mutilation, eye involvement, hemolytic anemia and hypersplenism. The treatment is complex and it is based in the photoprotection...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29537991/acral-spitz-nevi-a-clinicopathologic-study-of-50-cases-with-immunohistochemical-analysis-of-p16-and-p21-expression
#11
Katharina Wiedemeyer, Antonio Guadagno, Jonathan Davey, Thomas Brenn
Spitz nevi on acral sites are rare and poorly documented. The combination of Spitzoid cytomorphology and atypical architectural features of the junctional component may lead to an erroneous diagnosis of melanoma. To study the clinicopthologic and immunohistochemical features, 50 Spitz nevi localized on the distal extremities were retrieved from departmental files. Clinical data and follow-up were obtained and the histologic features were analyzed. P16 and P21 immunohistochemical staining of the dermal component was compared with that of 10 acral lentiginous melanomas and 10 acral nevi...
March 13, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29532621/comparison-between-the-efficacy-of-microneedling-combined-with-5-fluorouracil-vs-microneedling-with-tacrolimus-in-the-treatment-of-vitiligo
#12
Mary Mina, Lamia Elgarhy, Hanan Al-Saeid, Zeinab Ibrahim
BACKGROUND: Several treatment modalities had been used for the treatment of vitiligo, but the optimal treatment has not yet been identified. OBJECTIVES: To study the efficacy of microneedling with 5-flurouracil vs its efficacy with tacrolimus in the treatment of vitiligo. PATIENTS AND METHODS: Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch...
March 12, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29531493/left-supraclavicular-swelling-sclerosing-perineurioma
#13
Antonio Tancredi, Paolo Graziano, Lucia Dimitri, Elvira Impagnatiello, Marco Taurchini
A sclerosing perineurioma presents as a single asymptomatic papule or nodule located on the hands of adult patients; approximately 60 cases have been reported in medical literature since 1997. Histologically, it originates from the perineural cells of the peripheral nerves and presents epithelial membrane antigen (EMA) positivity and S100 protein negativity. Here, we present the case of a 58-year-old male admitted to our surgery unit complaining of left supraclavicular swelling of 1-cm in size, having no significant past medical history...
February 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29528339/cell-based-molecularly-targeted-therapy-targeting-oncoproteins-with-t-cell-receptor-gene-therapy
#14
Christian S Hinrichs
As oncogenes drive carcinogenesis and promote cancer cell survival, they are highly attractive therapeutic targets, and oncogene-targeting small molecules have achieved some clinical success. While many oncogenes are presently considered to be "druggable," tumors often acquire treatment resistance, and patients are rarely cured in response to oncogene-specific treatment. In this issue of the JCI, Veatch and colleagues describe a patient with metastatic acral melanoma who experienced a complete tumor response following infusion of tumor-infiltrating T cells that targeted multiple tumor antigens, including a BRAFV600E driver mutation...
March 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29513718/acral-melanoma-detection-using-a-convolutional-neural-network-for-dermoscopy-images
#15
Chanki Yu, Sejung Yang, Wonoh Kim, Jinwoong Jung, Kee-Yang Chung, Sang Wook Lee, Byungho Oh
BACKGROUND/PURPOSE: Acral melanoma is the most common type of melanoma in Asians, and usually results in a poor prognosis due to late diagnosis. We applied a convolutional neural network to dermoscopy images of acral melanoma and benign nevi on the hands and feet and evaluated its usefulness for the early diagnosis of these conditions. METHODS: A total of 724 dermoscopy images comprising acral melanoma (350 images from 81 patients) and benign nevi (374 images from 194 patients), and confirmed by histopathological examination, were analyzed in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29512974/acral-melanoma-correlating-the-clinical-presentation-to-the-mutational-status
#16
Giulia M Ravaioli, Emi Dika, Martina Lambertini, Marco A Chessa, Pier A Fanti, Annalisa Patrizi
Acral lentiginous melanoma (ALM) is the most common type of malignant melanoma (MM) in Asians, Afro-Americans and Middle-Easterns. It represents 1.5-10% of all MM cases, being the most common histological type of MM arising on palms, soles and nail apparatus, which is more generically defined as acral MM. To date no risk factors have been officially established, however a history of trauma may be involved in the pathogenesis of acral MM. This shows heterogeneous clinical features and frequently presents with advanced stage and aggressive behaviour, often as a result of misdiagnosis or delayed identification...
March 6, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29505523/aberrations-and-clinical-significance-of-braf-in-malignant-melanoma-a-series-of-60-cases-in-chinese-uyghur
#17
Xiaojing Kang, Ying Zeng, Junqin Liang, Jing Li, Danyang Ren, Li Chai, Zhenzhu Sun, Shirong Yu, Xiujuan Wu, Wen Han, Weijia Wang
Malignant melanoma (MM) is a highly malignant melanocytic tumor, it occurs mostly in the skin, the mucous membrane close to the skin, but also in the tunicae rhagoides and the pia mater. The Uyghur is the largest ethnic group living in the Xinjiang Uyghur Autonomous Region of China, accounting for 46% of the total population of 20 million. Large-scale studies on MMs in Asian countries are limited. This study aimed to investigate BRAF mRNA expression and mutations in Chinese Uyghur patients with MMs and to identify the clinical features associated with these parameters...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29484669/in-transit-sentinel-node-drainage-as-a-prognostic-factor-for-patients-with-cutaneous-melanoma
#18
Paulo H D M Brandão, Eduardo Bertolli, Eduardo Doria-Filho, Ivan D A O Santos Filho, Mariana P de Macedo, Clovis A L Pinto, João P Duprat Neto
BACKGROUND: Minor basin or in transit node drainage can be found in patients with cutaneous melanoma who undergo sentinel node biopsy. Its clinical impact is still unclear. Our objective is to evaluate clinical outcomes in patients who presented with in transit sentinel node (ITN) drainage. MATERIAL AND METHODS: Retrospective analysis of patients who underwent sentinel node biopsy (SNB) in a single Brazilian institution between 2000 and 2015. RESULTS: Our cohort comprised 1223 SNB...
February 26, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29484003/another-case-of-interdigital-located-metastasing-hematoma
#19
Georgi Tchernev, Ivan Pidakev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
Interdigital spaces could be an area of affection of a various cutaneous conditions, most of them with benign origin. The spectrum of differential diagnosis of pigmented interdigital lesions with a recent occurrence is not so wide, in contrast. When considering pigmented lesions in the interdigital area, the most harmless differential diagnosis is a traumatic hematoma. But what would happen if we based our therapeutic behaviour or suspicious and unconfirmed harmless diagnosis, instead of considering the real life-threatening once with priority, if we kept in mind that acral lentiginous melanoma has rather an aggressive course and is the main cause of death in skin cancer patients? We present a case of misdiagnosed interdigital melanoma, treated as a hemangioma with curettage, with almost fatal consequences, in regard to uncontrolled tumor progression as a result of the wrong traumatic procedure in one hand, and the lack of adequate screening and follow up, leading to progress of the disease with lymph node metastasis and poor prognosis in general...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29469698/acquired-bullous-acrodermatitis-enteropathica-as-a-histologic-mimic-of-pemphigus-foliaceus-in-a-patient-on-parenteral-nutrition
#20
Davina Wu, Maxwell A Fung, Maija Kiuru, Victoria R Sharon
Acquired zinc deficiency can develop as a consequence of poor nutritional intake or from dependence on total parenteral nutrition. Acquired zinc deficiency dermatitis classically manifests with erosions and scaly plaques in a periorificial and acral distribution. We present a case of a woman on parenteral nutrition who presented with bullous acrodermatitis mimicking pemphigus foliaceus histopathologically. This case highlights clinical and histopathologic variants of zinc deficiency that may lead to a delay in diagnosis...
July 15, 2017: Dermatology Online Journal
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