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https://www.readbyqxmd.com/read/29218293/acral-hypomelanocytic-melanoma-of-left-great-toe-a-rare-cancer
#1
Mohd Altaf Mir, Varun Chauhan, Ali Adil Mahmud, Lalit Mohan Bariar, Suhailur Rehman
No abstract text is available yet for this article.
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29208888/polyarthritis-is-a-rare-manifestation-of-pachydermoperiostosis-a-case-report
#2
M F Ahmmed, M N Shazzad, S Ferdous, A K Azad, S A Haq
Pachydermoperiostosis or primary hypertrophic osteoarthropathy, also known as Touraine-Solente-Gole syndrome, is a rare process, frequently inherited. In its complete form it is characterized by pachydermia (thickening of the skin), skeletal changes (periostosis) and acropachia (digital clubbing). Diagnosis can be made considering the typical clinical features and the histological feature. We report a patient of 25-year old man presented with joint pain involving in multiple joints for last 7 years and progressive enlargement of his hands and feet with profuse sweating of palms and soles for last 4 years...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29205494/acral-accentuated-exanthem-in-an-infant-with-parechovirus-meningitis
#3
Dawn Lee, Sin Wee Loh, Juliet Tan, Jinho Chong
We report a case of an infant who had presented with fever and an acral-accentuated rash, for which his cerebrospinal fluid returned positive for parechovirus. He was treated symptomatically and discharged well, with no long-term complications.
December 4, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29204392/subungual-melanoma-is-not-so-rare-report-of-four-cases-from-india
#4
Archana Singal, Deepika Pandhi, Priyanka Gogoi, Chander Grover
Subungual melanoma (SUM) is an uncommon form of acral melanoma that arises within the nail matrix. The incidence for acral melanomas is similar worldwide, however, the proportion is higher in dark-skinned individuals. The subungual form represents approximately 2% of cutaneous non-sun-induced melanomas in the western world and up to 75% in Africans, 10% in Japanese, and 25% in the Chinese. No specific figures are available from the Indian subcontinent; however, the authors could trace three anecdotal case reports published over the last two decades...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29201953/concurrent-hand-and-penile-gangrene-following-prolonged-warfarin-use-a-case-report
#5
Fatemeh Mahdizadeh, Saeed Safari
Warfarin induced skin necrosis (WISN) is a rare but important side effect of warfarin. Early diagnosis may lessen the amount of permanent tissue damage and can prevent progression to full thickness skin necrosis. So, physicians should be aware of such a complication. Screening for protein C or S or anti-thrombin deficiencies, or presence of anti-phospholipid antibodies before beginning warfarin therapy, could be helpful to avoid high levels of international normalized ratio (INR). Here, we report a 54-year-old man who presented to the emergency department with acral and penile gangrene following prolonged use of warfarin...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/29201043/clinical-and-genetic-review-of-hereditary-acral-reticulate-pigmentary-disorders
#6
REVIEW
H Alshaikh, F Alsaif, S Aldukhi
Reticulated pigmentation is a unique pigmentary change caused by a heterogeneous group of hereditary and acquired disorders. This pigmentation is characterized by a mottled appearance, with lesions that vary in size and pigmentary content. This review discusses the hereditary group of the reticulated pigmentation disorders, such as dyschromatosis symmetrica hereditaria, dyschromatosis universalis hereditaria, and reticulate acropigmentation of Kitamura. The clinical presentation and histopathological features often overlap, making diagnosis difficult...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29194789/dermoscopic-features-and-patterns-of-poromas-a-multicenter-observational-case-control-study-conducted-by-the-international-dermoscopy-society-ids
#7
M A Marchetti, M L Marino, P Virmani, S W Dusza, A A Marghoob, G Nazzaro, A Lallas, C Landi, H Cabo, R Quiñones, E Gomez, S Puig, C Carrera
BACKGROUND: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterised. OBJECTIVE: To determine the clinical-dermoscopic features of poromas. METHODS: Cross-sectional, observational study of 113 poromas and 106 matched control lesions from 16 contributors and eight countries. Blinded reviewers evaluated the clinical and dermoscopic features present in each clinical and dermoscopic image...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29194782/acral-lamellar-ichthyosis-expanding-the-phenotype-of-temperature-sensitive-keratinization-disorders
#8
Hiram de Almeida, Cristina Has, Judith Fischer, Ingrid Hausser
Lamellar ichthyosis is a MEDOC (Mendelian disorders of cornification) that belongs to the ARCI group (Autosomal recessive congenital ichthyosis) 1 , characterized by large brownish scaly lesions tightly adherent, with typical involvement of the face, which may lead to ectropion. Mutations in at least 12genes have been described in the ARCI group2 . This article is protected by copyright. All rights reserved.
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29191620/genetic-alterations-in-primary-acral-melanoma-and-acral-melanocytic-nevus-in-korea-common-mutated-genes-show-distinct-cytomorphological-features
#9
Ki Rang Moon, Yoo Duk Choi, Jung Min Kim, Suna Jin, Min-Ho Shin, Hyun-Jeong Shim, Jee-Bum Lee, Sook Jung Yun
Acral melanoma occurring on the palms, soles, and nails is the most common subtype of cutaneous melanoma in Asians. Genetic alterations in acral melanoma and acral melanocytic nevus are not well known. We performed next-generation sequencing and evaluated the correlations between genetic information and the clinicopathologic characteristicsfrom 85 Korean patients with acral melanocytic neoplasms. Of the 64 patients with acral melanoma, most had ≥ T2 stage, and the heel was the most common anatomical site of melanoma (n = 34, 53...
November 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29187493/braf-nras-and-c-kit-advanced-melanoma-clinico-pathological-features-targeted-therapy-strategies-and-survival
#10
Giovanni Ponti, Marco Manfredini, Stefano Greco, Giovanni Pellacani, Roberta Depenni, Aldo Tomasi, Monia Maccaferri, Stefano Cascinu
BACKGROUND/AIM: The mutational status of stage III and IV melanomas should be recognized in order to allow for targeted therapies. The aim of our study was the characterization of BRAF, NRAS and C-KIT melanoma patients, in order to define their optimal management. PATIENTS AND METHODS: Between 1991 and 2015, 63 mutated melanoma patients were treated and monitored during their diagnostic and therapeutic management at a single institution. RESULTS: BRAF-mutated melanoma patients were the most common, representing 70% of the study population, while NRAS- and C-KIT-mutated melanoma represented 19% and 11% respectively...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29184811/dermatologic-manifestations-of-endocrine-disorders
#11
REVIEW
Michael Lause, Alisha Kamboj, Esteban Fernandez Faith
The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. In acromegaly, glycosaminoglycan deposition contributes to a thickening of skin and soft tissue, which manifests as coarsening and enlargement of facial and acral structures...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29181206/atypical-histiocyte-rich-sweet-s-syndrome
#12
Sharon Chi, Marcia Leung, Mark Carmichael, Michael Royer, Sunghun Cho
Sweet's Syndrome is a rare neutrophilic dermatosis thought to be a result of immune dysregulation occurring in the setting of drug exposure, recent infection, pregnancy, and underlying malignancy or idiopathic with specific and widely accepted diagnostic criteria established in the literature. Other organ systems can be involved with varying degrees of severity. An unusual case of Sweet's Syndrome associated with myopericarditis, acral involvement, and atypical histological findings with predominance of histiocytes is described here...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29179948/large-deletions-targeting-the-triple-helical-domain-of-collagen-vii-lead-to-mild-acral-dominant-dystrophic-epidermolysis-bullosa
#13
Nadja Chmel, Olivier Bornert, Ingrid Hausser, Gabriele Grüninger, Wiktor Borozkin, Jürgen Kohlhase, Alexander Nyström, Cristina Has
No abstract text is available yet for this article.
November 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29178552/educational-and-practice-gaps-in-the-management-of-volar-melanocytic-lesions
#14
C M Costello, S Ghanavatian, M Temkit, M R Buras, D J DiCaudo, D L Swanson, A R Mangold
BACKGROUND: The benign and malignant patterns of acral melanocytic nevi (AMN) and acral melanomas (AM) have been defined in a series of retrospective studies. A 3-step algorithm was developed to determine when to biopsy acral melanocytic lesions. This algorithm has only been applied to a Japanese population. OBJECTIVES: Our study aimed to review the current management strategy of acral melanocytic lesions and to investigate the utility of the 3-step algorithm in a predominately Caucasian cohort...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29164678/speckled-acral-hypopigmentation-in-an-adolescent
#15
Veronica L Rutt, Kelly B Quinn, Andrea Zaenglein
We report a case of speckled acral hypopigmentation in a 12-year-old girl. She presented with asymptomatic hypopigmented macules on the hands and feet. This rare entity is a proposed variant of reticulate acropigmentation and of unknown etiology.
November 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29161683/out-of-the-blue-finger-ischaemia-and-occult-colorectal-cancer
#16
Ami Schattner
A woman aged 66 years with a history of unprovoked deep venous thrombosis (DVT) presented with persistent digital ischaemic changes of 2 of her right hand fingers. Physical examination was otherwise normal and extensive laboratory and imaging studies were unremarkable. A history of unprovoked DVT and the current episode of digital ischaemia prompted concern for underlying occult malignancy. Repeated history-taking revealed a strongly positive family history suggesting an occult colorectal cancer. Colonoscopy with biopsy revealed adenocarcinoma...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29156643/melanoma-genetic-abnormalities-tumor-progression-clonal-evolution-and-tumor-initiating-cells
#17
REVIEW
Ugo Testa, Germana Castelli, Elvira Pelosi
Melanoma is an aggressive neoplasia issued from the malignant transformation of melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of deaths due to skin cancers. Melanoma is a phenotypically and molecularly heterogeneous disease: cutaneous, uveal, acral, and mucosal melanomas have different clinical courses, are associated with different mutational profiles, and possess distinct risk factors. The discovery of the molecular abnormalities underlying melanomas has led to the promising improvement of therapy, and further progress is expected in the near future...
November 20, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29141225/a-comprehensive-patient-derived-xenograft-collection-representing-the-heterogeneity-of-melanoma
#18
Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, Min Xiao, Batool Shannan, Andrea Watters, Michela Perego, Gao Zhang, Adina Vultur, Xiangfan Yin, Qin Liu, Ioannis N Anastopoulos, Bradley Wubbenhorst, Melissa A Wilson, Wei Xu, Giorgos Karakousis, Michael Feldman, Xiaowei Xu, Ravi Amaravadi, Tara C Gangadhar, David E Elder, Lauren E Haydu, Jennifer A Wargo, Michael A Davies, Yiling Lu, Gordon B Mills, Dennie T Frederick, Michal Barzily-Rokni, Keith T Flaherty, Dave S Hoon, Michael Guarino, Joseph J Bennett, Randall W Ryan, Nicholas J Petrelli, Carol L Shields, Mizue Terai, Takami Sato, Andrew E Aplin, Alexander Roesch, David Darr, Steve Angus, Rakesh Kumar, Ensar Halilovic, Giordano Caponigro, Sebastien Jeay, Jens Wuerthner, Annette Walter, Matthias Ocker, Matthew B Boxer, Lynn Schuchter, Katherine L Nathanson, Meenhard Herlyn
Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity of melanoma...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29135278/acral-fibrokeratoma-a-rare-pedal-soft-tissue-mass
#19
Dyane E Tower, Jeffrey R Hammond
Acral fibrokeratoma (AF) is a rare soft tissue mass, more commonly found on the hands and rarely on the feet. This case report of a 40-year-old Hispanic male highlights an unusually located AF on the second toe, describes the clinical presentation, microscopic and pathologic findings, discusses differential diagnoses and presents treatment options.
November 14, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29104695/multiple-primary-acral-lentiginous-melanomas-mpalm
#20
Miriam González, Georgi Tchernev, Anastasiya Atanasova-Chokoeva, Katlein França, Torello Lotti
We present a rare case of a patient with multiple primary acral lentiginous melanomas of the foot. We would like to highlight the importance of whole-skin examination in all patients, even by the general practitioners, aiming the maximal early detection of acral lentiginous melanomas, considering their rapid progression, early metastatic spread and extremely poor prognosis. It can be extrapolated from current literature; however, that appropriate management of these patients, including staging work and surgical intervention, is to be determined by the individual characteristics of the melanoma and the patient's concomitant risk factors, if any...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
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