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Juliana Polizel Ocanha-Xavier, José Cândido Caldeira Xavier-Junior, Mariângela Esther Alencar Marques
BACKGROUND: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. OBJECTIVE: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. METHODS: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up...
June 2018: Anais Brasileiros de Dermatologia
Je-Ho Mun, Gwanghyun Jo, Claudia C Darmawan, Jin Park, Jung Min Bae, HyunJu Jin, Woo-Il Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: Dermoscopy is a useful tool for the diagnosis of acral melanomas (AM). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM. OBJECTIVE: To investigate the impact of Breslow thickness (BT) on the dermoscopic patterns of AM. METHODS: Data on cases of AM on the glabrous skin were collected from four university hospitals. We investigated the frequency of each dermoscopic feature of AM according to the BT...
June 12, 2018: Journal of the American Academy of Dermatology
Priyanka Jalandhara, Gurjit Kaeley
Chemotherapy-induced acral erythema has been a known side effect of intravenous dosing but has not been reported with oral therapy. Herein we describe two patients receiving treatment with low-dose oral methotrexate who presented with acral erythema. Clinicians and rheumatologists should be aware of this potentially serious side effect of oral chemotherapy in various patient populations. This complication related to methotrexate, though rare, should be anticipated in patients on multiple medications who develop mucocutaneous toxicities...
July 2018: Proceedings of the Baylor University Medical Center
Xiao Ke Liu, Jun Li
No abstract text is available yet for this article.
June 9, 2018: Lancet
Toshiaki Kogame, Yo Kaku, Yuichiro Endo, Chisato Yamashita, Ayumi Horiguchi, Akiharu Kubo, Kenji Kabashima
No abstract text is available yet for this article.
June 11, 2018: European Journal of Dermatology: EJD
Anuradha Bishnoi, Davinder Parsad
No abstract text is available yet for this article.
May 2018: Journal of Cutaneous Medicine and Surgery
Janelle Cyr, Annie Liu, Danny Ghazarian, Sanjay Siddha
Epidermolysis bullosa acquisita (EBA) is a rare acquired type of mechanobullous disease affecting the dermal-epidermal junction (DEJ) of trauma prone acral surfaces. It manifests as tense vesicles, bullae, and milia and typically heals as atrophic hypo- or hyperpigmented scars. Classic noninflammatory mechanobullous EBA typically presents at a mean age of 48 years. A 21-year-old man presented with a 2-year history of nonpainful papular-vesicular lesions on his hands, knees, and toes after minor trauma to these areas...
May 2018: Journal of Cutaneous Medicine and Surgery
Faruk Tas, Kayhan Erturk
BACKGROUND/AIMS: Acral lentiginous melanoma (ALM) is a small subtype of melanoma affecting Caucasians far more often than other ethnic groups, such as blacks, Hispanics, and Asians. Only a few studies have yielded controversial results on ALM so far. The aim of this study was to define the histopathological and clinical expressions of ALM and to compare them with those of non-ALM in a large group of Turkish patients from a single referral institution. METHODS: One hundred two ALM patients were analyzed retrospectively...
June 1, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Esther M Häfliger, Egle Ramelyte, Joanna Mangana, Michael Kunz, Dmitry V Kazakov, Reinhard Dummer, Phil F Cheng
Acral lentiginous melanoma (ALM) is a unique histopathological subtype of melanoma with a poorer prognosis than other cutaneous melanomas. This study aims to evaluate the clinicopathological characteristics, metastatic pattern, prognostic factors, response to systemic therapy, and overall survival (OS) of ALM in a White population. This is a retrospective study of patients who were diagnosed and/or treated for ALM at the Department of Dermatology of the University Hospital Zurich, Switzerland, from January 2005 to December 2015...
May 29, 2018: Melanoma Research
A Gómez-Zubiaur, I Spanoudi-Kitrimi, A Torrelo
No abstract text is available yet for this article.
May 26, 2018: Actas Dermo-sifiliográficas
Lizeth Yamile Urrea-Pineda, Sebastián Gómez-Jiménez, Daniel Jaramillo-Arroyave, Carlos Horacio Muñoz-Vahos, Adriana Lucía Vanegas-García, Gloria Vasquéz, Mauricio Restrepo-Escobar, Luis Alonso González-Naranjo
We report the case of a 47-year-old man with a 9-year history of psoriatic arthritis (PsA) in whom we detected renal involvement, hypocomplementemia, peripheral neuropathy, acral necrotic lesions and positive cryoglobulins. The results of the diagnosis led us to conclude that the clinical picture corresponded to cryoglobulinemic vasculitis concomitant with PsA. In addition, we present a review of the literature on the presence of these two diseases in a single patient.
May 19, 2018: Reumatología Clinica
Fezal Ozdemir, Micol A Errico, Banu Yaman, Isil Karaarslan
Background: The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants. Objectives: To calculate the proportion of ALM among all melanoma subtypes and to determine the frequency of dermoscopic features of ALM in the Turkish population. Methods: Out of 612 melanomas, there were 70 cases of ALM, of which 46 showed sufficient image quality for retrospective study of dermoscopic features...
April 2018: Dermatology Practical & Conceptual
Jasmine Saleh, Michael L Wang, Paul W Harms, Rajiv M Patel, Douglas R Fullen
Osteocartilaginous differentiation in malignant melanoma is rare and can pose a diagnostic challenge. In previously reported cases, melanomas were predominantly located on acral and mucosal sites with osteocartilaginous differentiation present in either primary or recurrent lesions. We report a case of a 52-year-old female with malignant melanoma located on the right upper back exhibiting osteosarcomatous differentiation only in the axillary lymph node metastasis. This case serves to highlight that the divergent differentiation can occur in lymph node metastases while being absent in the primary lesion...
May 20, 2018: Journal of Cutaneous Pathology
Jih Huei Tan, Yuzaidi Mohamad, Chor Lip Henry Tan, Mahazir Kassim, Theodore E Warkentin
BACKGROUND: Symmetrical peripheral gangrene is characterized as acral (distal extremity) ischemic limb injury affecting two or more extremities, without large vessel obstruction, typically in a symmetrical fashion. Risk factors include hypotension, disseminated intravascular coagulation, and acute ischemic hepatitis ("shock liver"). In contrast, venous limb gangrene is characterized by acral ischemic injury occurring in a limb with deep vein thrombosis. Both symmetrical peripheral gangrene and venous limb gangrene present as acral limb ischemic necrosis despite presence of arterial pulses...
May 19, 2018: Journal of Medical Case Reports
Yunfang Han, Zhongzhi Jia
No abstract text is available yet for this article.
May 14, 2018: European Journal of Vascular and Endovascular Surgery
V Van-de-Velde, G Kravvas, G Ali, A Biswas, L Naysmith
No abstract text is available yet for this article.
May 10, 2018: Clinical and Experimental Dermatology
Hui Z Gong, He Y Zheng, Jun Li
This study aimed to evaluate the association of KIT mutations with clinicopathologic features of melanomas using a meta-analysis and to identify differences between Asian and White populations using subgroup analyses. We selected 32 studies from the literature including 5224 patients. The pooled data were combined, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity and publication bias were also determined. KIT mutations were reported in 497 (9.5%) of 5224 patients with melanomas, and were associated significantly with age, clinical melanoma subtype, anatomic location, and chronic sun-damage (CSD), but not with sex, histological type, Breslow thickness, ulceration, mitotic rate, or tumor stage...
May 9, 2018: Melanoma Research
E Matutes
Over the last decade, there has been a significant body of information regarding the biology of the lymphoid neoplasms. This clearly supports the need for updating the 2008 WHO (World Health Organization) classification of haematopoietic and lymphoid tumours. The 2017 WHO classification is not a new edition but an update and revision of the 4th edition. New provisional entities but not new definitive entities are included, and novel molecular data in most of the entities and changes in the nomenclature in few of them have been incorporated...
May 2018: International Journal of Laboratory Hematology
Je-Byeong Chae, Gwnaghyun Jo, Je-Ho Mun
No abstract text is available yet for this article.
May 9, 2018: International Journal of Dermatology
S M Esmat, O A Zeid, D M Abdel Halim, M T Fawzy, M Abdel Latif, V Lazarova, M Assaf
The role of epidermal keratinocytes in the pathogenesis of vitiligo has been ignored despite the fact that both melanocytes and keratinocytes form one functional and structural unit. Aquaporin3 (AQP3), a glycerol water channel expressed in epithelial tissue, is involved in the regulation of keratinocyte proliferation, cell migration, and has a potential role in hypopigmentation in vitiligo. Normally, acral skin differs significantly from non-acral skin. Acral skin shows significantly lower hair follicle density, melanocyte density, Langerhans cell (LC) density, epidermal MHCII expression...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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