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https://www.readbyqxmd.com/read/29452217/gene-expression-screening-identifies-cdca5-as-a-potential-therapeutic-target-in-acral-melanoma
#1
Tianxiao Xu, Meng Ma, Jie Dai, Sifan Yu, Xiaowen Wu, Huan Tang, Jiayi Yu, Junya Yan, Huan Yu, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Yan Kong, Jun Guo
Acral melanoma (AM) is a rapidly progressing subtype of melanoma with poor prognosis. The complete array of molecular changes that occur during AM metastasis remains unclear. In this study, we compared the gene expression profiles of six primary and 12 lymph node metastatic AM samples by tissue microarray analysis. We found that the expression levels of 396 genes were increased, and that of 766 genes were decreased in the metastatic tissues compared with that in the primary tumors. The top 19 genes upregulated in the metastatic tissue specimens were selected for high-content short interfering (si)RNA screening...
February 13, 2018: Human Pathology
https://www.readbyqxmd.com/read/29447642/is-it-just-a-psoriasiform-dermatitis
#2
Olalla Figueroa-Silva, Martina Espasandín-Arias, Francisco Javier García-Martínez, Virginia Fernández-Redondo, Jaime Toribio
Bazex syndrome (BS) is a rare paraneoplastic syndrome most frequently associated with squamous cell carcinomas of the upper aerodigestive tractand other tumours. Characteristically, cutaneous lesions precede the diagnosis of malignancy. We report a 72-year-old patient with 1-year history of acral dermatitis. The diagnosis of BS was based on the presence of psoriasiform acral dermatitis and the evidence of two simultaneous tumors (prostate adenocarcinoma and undifferentiated carcinoma ofthe submandibular gland)...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29446850/superficial-acral-fibromyxoma-in-the-heel-with-new-vascular-features-on-dermoscopy
#3
Asude Kara Polat, Muge Gore Karaali, Asli Vefa Turgut Erdemir, Ayse Esra Koku Aksu, Cem Leblebici, Mehmet Salih Gurel
Superficial acral fibromyxoma (SAFM) is an uncommon mesencyhmal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant neoplasms. We report a case of SAFM in a rare localization in the heel with a new entity on dermoscopy.
February 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29445581/eruptive-nevi-after-burn-injury
#4
Ali Tareen, Kristine Pallesen, Tine Vestergaard
Eruptive melanocytic nevi (EMN) is an unusual phenomenon characterized by the abrupt development of multiple melanocytic nevi over weeks to months in association with an underlying trigger. The underlying mechanisms are not fully understood, however, they have been associated with a variety of conditions. EMN is relatively uncommon and might be underreported due to the absence of close monitoring, insufficient recognition, and the presumed benign course of the condition. We describe the first case report of acral EMN associated with a burn wound on a 2-year-old child...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29441559/prognostic-features-for-acral-lentiginous-melanoma
#5
EDITORIAL
A E Cust
No abstract text is available yet for this article.
February 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29441299/livedo-racemosa-reticulated-ulcerations-panniculitis-and-violaceous-plaques-in-a-46-year-old-woman
#6
Alfredo Agulló, Brian Hinds, Mónica Larrea, Ignacio Yanguas
Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) that has conventional cutaneous manifestations of DM, but paradoxically, little or no muscle involvement. In 2005, a novel antibody was described in association with CADM - anti-melanoma differentiation-associated gene 5 (anti-MDA5). Patients with this serologic marker have a characteristic mucocutaneous phenotype consisting of skin ulceration among other signs. We describe the case of a 46-year-old woman with CADM, elevated anti-MDA5 autoantibodies, and unusual clinical features (livedo racemosa, florid acral edema) among the classical phenotype of MDA5 DM (arthralgias, ulcerations, panniculitis) and classical DM lesions (Gottron papules, heliotrope rash)...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29440960/acral-acroma-malignant-melanoma-a-clinical-case-report-and-review-of-literature
#7
Corina-Maria Botici, Lăcrimioara Covaci, Claudia Judea-Pusta, Andrei Paşcalău
Objective: The main objective of this paper is to emphasize the importance of the early diagnosis of certainty in the cases of acral-acroma malignant melanoma in order to increase the survival rate. Method: The paper is a review of specialty literature and presents a clinical case of acral-acroma malignant melanoma. Clinical case: acral-acroma malignant melanoma with confirmed lymph node metastases and possibly secondary remote dissemination to the skin in a male patient aged 16 years...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29438763/whole-exome-sequencing-reveals-differences-between-nail-apparatus-melanoma-and-acral-melanoma
#8
Minho Lee, Jonghwan Yoon, Yeun-Jun Chung, Soo Young Lee, Jin Young Choi, Ok Ran Shin, Ho Yeon Park, Won-Jong Bahk, Dong Soo Yu, Young Bok Lee
No abstract text is available yet for this article.
February 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29425092/paraneoplastic-acral-vascular-syndrome
#9
Satish Maharaj, Simone Chang, Karan Seegobin, Carmen Isache
No abstract text is available yet for this article.
February 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29423724/superficial-acral-fibromyxoma-a-case-report-with-radiological-review
#10
Shirly Lee, Michael Austin Ross Reid
Superficial acral fibromyxoma is a benign, slow-growing soft-tissue neoplasm that has a predilection for the peripheries. Although considered benign, its risk of recurrence warrants consideration in the radiological differential diagnoses of acral tumors. To our knowledge, there has been minimal literature studying the radiological features of this entity. We present a case report with a discussion focusing on its clinical and radiological findings.
February 8, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29415335/high-density-of-m2-macrophages-in-acral-lentiginous-melanoma-compared-to-superficial-spreading-melanoma
#11
M Zúñiga-Castillo, N V Pereira, M N Sotto
AIMS: Acral lentiginous melanoma (ALM) is the most common type of melanoma in people with darker skin phototypes. There is some evidences that the etiology, pathogenesis, risk factors, and natural history of ALM differ from those of superficial spreading melanoma (SSM). ALM behaves more aggressively than SSM, but the biological explanation for these differences remains unknown. The presence of one subtype of macrophages, termed M2-macrophage (M2-M), has been found to be related to local progression, metastasis, and poor prognosis in several neoplasms...
February 7, 2018: Histopathology
https://www.readbyqxmd.com/read/29389327/clinical-epidemiological-and-molecular-heterogeneity-in-acral%C3%A2-melanoma
#12
Cristina Carrera, Joan Anton Puig-Butille
Acral melanoma comprises a poorly characterized and distinct type of melanoma, in terms of differing roles of UVR, molecular substrate, distribution among all ethnicities, and poor prognosis. Haugh et al. explore clinical, histological, and molecular aspects of acral melanomas and provide insights into the complexity of these tumors.
February 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29387874/combination-of-follicular-and-epidermal-cell-suspension-as-a-novel-surgical-approach-in-difficult-to-treat-vitiligo-a-randomized-clinical-trial
#13
Muhammed Razmi T, Ravinder Kumar, Seema Rani, Sendhil M Kumaran, Sushma Tanwar, Davinder Parsad
Importance: Epidermal cell suspension (ECS) and follicular cell suspension (FCS) are successful surgical modalities for the treatment of stable vitiligo. However, repigmentation in generalized and acrofacial vitiligo and over acral or bony sites (eg, elbows, knees, iliac crests, and malleoli), which are difficult to treat, is challenging. Objective: To study the efficacy of transplanting a combination of autologous, noncultured ECS and FCS (ECS + FCS) compared with ECS alone in stable vitiligo...
January 31, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29382519/-acrodermatitis-enteropathica
#14
María Elena Martínez-Bustamante, Rubén Peña-Vélez, Enory Almanza-Miranda, Carlos Andrés Aceves-Barrios, Tonatiuh Vargas-Pastrana, Alfredo Raúl Rodolfo Morayta-Ramírez Corona
INTRODUCTION: Acrodermatitis enteropathica is a low-incidence disease due to inherited or acquired zinc deficiency. It is characterized by acral dermatitis, alopecia, diarrhea and growth retardation. The dermatological condition may mimic a cutaneous fungal infection or other pathogen-related skin diseases. CASE REPORT: We report the case of a female patient of 7 months of age, who was sent to Centro Médico Nacional 20 de Noviembre for suspicion of immunodeficiency and cutaneous mycosis...
July 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29366969/acral-myxoinflammatory-fibroblastic-sarcoma-simulating-rheumatoid-bursitis-diffusion-weighted-imaging
#15
Aline Serfaty, Flavia Costa, Ierecê Lins Aymore, Walter Meohas, Clarissa Canella, Edson Marchiori
No abstract text is available yet for this article.
January 20, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29361273/multiple-acral-syringomas
#16
C Gómez-de Castro, B Vivanco Allende, B García-García
No abstract text is available yet for this article.
January 17, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29360681/superficial-acral-fibromyxoma-with-cartilaginous-metaplasia
#17
Isabelle Moulonguet, Sophie Goettmann, Ines Zaraa
No abstract text is available yet for this article.
January 22, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29360643/tumor-infiltrating-brafv600e-specific-cd4-t-cells-correlated-with-complete-clinical-response-in-melanoma
#18
Joshua R Veatch, Sylvia M Lee, Matthew Fitzgibbon, I-Ting Chow, Brenda Jesernig, Thomas Schmitt, Ying Ying Kong, Julia Kargl, A McGarry Houghton, John A Thompson, Martin McIntosh, William W Kwok, Stanley R Riddell
T cells specific for neoantigens encoded by mutated genes in cancers are increasingly recognized as mediators of tumor destruction after immune checkpoint inhibitor therapy or adoptive cell transfer. Unfortunately, most neoantigens result from random mutations and are patient specific, and some cancers contain few mutations to serve as potential antigens. We describe a patient with stage IV acral melanoma who obtained a complete response following adoptive transfer of tumor infiltrating lymphocytes (TIL). Tumor exome sequencing surprisingly revealed less than 30 somatic mutations, including oncogenic BRAF V600E...
January 23, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29355898/in-vivo-dermoscopic-and-confocal-microscopy-multi-step-algorithm-to-detect-in-situ-melanomas
#19
S Borsari, R Pampena, E Benati, C Bombonato, K Athanassios, E Moscarella, A Lallas, G Argenziano, G Pellacani, C Longo
BACKGROUND: Although several dermoscopic features of in situ melanoma (MIS) have been identified, data on confocal features for MIS are still lacking. OBJECTIVES: To identify RCM (reflectance confocal microscopy) features of MIS and to develop a diagnostic score for MIS while combining dermoscopy and RCM. METHODS: 120 MIS and 213 nevi (test set) were retrospectively analysed to assess the presence of dermoscopic and RCM criteria. Facial and acral lesions have been excluded...
January 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29352387/current-perspectives-on-erythema-multiforme
#20
REVIEW
Marianne Lerch, Carlo Mainetti, Benedetta Terziroli Beretta-Piccoli, Thomas Harr
Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings...
January 19, 2018: Clinical Reviews in Allergy & Immunology
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