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https://www.readbyqxmd.com/read/28092366/malignant-melanoma-of-sun-protected-sites-a-review-of-clinical-histological-and-molecular-features
#1
Emily A Merkel, Pedram Gerami
In most cases of cutaneous melanoma, ultraviolet (UV) radiation is recognized as a prominent risk factor. Less is known regarding the mechanisms of mutagenesis for melanoma arising in sun-protected sites, such as acral and mucosal melanoma. Acral and mucosal melanoma share many common features, including a late age of onset, a broad radial growth phase with prominent lentiginous growth, the presence of field cancerization cells, and, in most cases, lack of a precursor nevus. In addition to early chromosomal instability, many of the same genes are also involved in these two distinct melanoma subtypes...
January 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28087024/acral-melanoma
#2
Flavia Persechino, Caterina Longo, Elisa Benati, Stefania Borsari, Mara Lombardi, Simonetta Piana, Giuseppe Argenziano, Elvira Moscarella
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28087020/acral-pseudolymphomatous-angiokeratoma-of-children-with-rainbow-pattern-a-mimicker-of-kaposi-sarcoma
#3
Víctor Hugo Pinos León, Jennyfer Daniela Granizo Rubio
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28087015/acral-persistent-papular-mucinosis-appm-dermoscopy-of-an-uncommon-disease
#4
Cristián Navarrete-Dechent, Shirin Bajaj, Ashfaq Marghoob, Sergio González, Alejandra Jaque
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28087014/parallel-globules-on-the-ridges-caused-by-transepidermal-elimination-of-melanocytic-nests-a-new-dermoscopic-pattern-of-acral-melanoma
#5
Giovanni Ghigliotti, Elena De Col, Franco Rongioletti
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28079921/four-cases-of-exogenous-acral-pigmentation-related-to-a-darkeling-beetle-coleoptera-tenebrionidae-blaps
#6
S Mokni, L Boussofara, W Saidi, A Aounallah, C Belajouza, N Ghariani, R Nouira, M Denguezli
Beetle (coleoptera) is the largest insect order colonizing all continents 1-2. Most of the beetles synthesize hemolymph containing several chemicals used as signals or defensive secretions against predators 2. Coleoptera body fluids can accidentally come into contact with humans' skin and induce dermatitis. Skin contact with the beetles commonly causes blistering skin eruption 3. This article is protected by copyright. All rights reserved.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28073583/clinical-factors-associated-with-subclinical-spread-of-in-situ-melanoma
#7
Thuzar M Shin, Jeremy R Etzkorn, Joseph F Sobanko, David J Margolis, Joel M Gelfand, Emily Y Chu, Rosalie Elenitsas, Waqas R Shaikh, Christopher J Miller
BACKGROUND: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%. OBJECTIVE: To identify clinical factors associated with subclinical spread of in situ melanoma. METHODS: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. The presence of subclinical spread was correlated with clinical characteristics...
January 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28067894/unexpected-uvr-and-non-uvr-mutation-burden-in-some-acral-and-cutaneous-melanomas
#8
Robert V Rawson, Peter A Johansson, Nicholas K Hayward, Nicola Waddell, Ann-Marie Patch, Serigne Lo, John V Pearson, John F Thompson, Graham J Mann, Richard A Scolyer, James S Wilmott
Ultraviolet radiation (UVR) mutagenesis causes nearly all cutaneous melanomas, however, since UVR signatures are largely absent in acral melanoma, as well as melanoma in sun-protected sites, the cause of these melanomas is unknown. Whole-genome sequencing data generated as part of the Australian Melanoma Genome Project was supplemented with a detailed histopathological assessment with the melanomas then classified as UVR or non-UVR related, based on their mutation signatures. The clinicopathological characteristics of melanomas with mutation signatures for their subtype were compared...
January 9, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28058733/acral-and-digital-angioleiomyomata-fourteen-year-experience-at-the-cleveland-clinic-and-review-of-the-literature
#9
Margaret I Hammond, Andrew G Miner, Melissa P Piliang
BACKGROUND: Angioleiomyoma is a benign neoplasm thought to derive from the tunica media of small venous vessels. Angioleiomyomata most frequently occur in the lower extremities with less common occurrences on the trunk, head, and upper extremities. Few cases of acral and digital angioleiomyoma have been described in the literature. METHODS: We add a series of twenty-one patients with acral angioleiomyoma including six cases of digital angioleiomyoma to the body of clinical and histologic findings along with a review of the literature of digital angioleiomyomata...
January 5, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28045748/superficial-acral-fibromyxoma-report-of-13-cases-with-new-immunohistochemical-findings
#10
Daniella Cullen, José Luis Díaz Recuero, Roberto Cullen, José Luis Rodríguez Peralto, Heinz Kutzner, Luis Requena
BACKGROUND: Superficial acral fibromyxoma (SAF) is a benign, soft tissue neoplasm preferably located on the digits. METHODS: We collected 13 cases of SAF and evaluated their clinical, histopathologic, and immunohistochemical features. RESULTS: This study included 9 males and 4 females, median age 54 years. The patients presented with a solitary asymptomatic or tender mass, most of them arising on fingers or toes. Histopathologically all lesions consisted of nonencapsulated dermal nodules, composed of spindled cells with variable myxoid and/or fibrotic stroma...
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28035704/extra-acral-cutaneous-sclerosing-perineurioma-with-cd34-fingerprint-pattern
#11
Ricardo S Macarenco, Jade Cury-Martins
Sclerosing perineuroma is a variant of extraneural perineurioma that, as a rule, occurs in acral sites. However, it has also been occasionally reported in non-acral regions. Recently, CD34 expression in a pattern reminiscent of the human fingerprint has been observed in a subset of perineuriomas, but this immunohistochemical finding has not been documented in non-acral sclerosing perineuriomas. We report a case of sclerosing perineurioma presenting CD34 expression in a fingerprint-like pattern on the skin of the neck (a previously unreported site for this neoplasm) of a 56-year-old man...
December 30, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28033318/a-point-mutation-in-a-lincrna-upstream-of-gdnf-is-associated-to-a-canine-insensitivity-to-pain-a-spontaneous-model-for-human-sensory-neuropathies
#12
Jocelyn Plassais, Laetitia Lagoutte, Solenne Correard, Manon Paradis, Eric Guaguère, Benoit Hédan, Alix Pommier, Nadine Botherel, Marie-Christine Cadiergues, Philippe Pilorge, David Silversides, Maud Bizot, Mark Samuels, Carme Arnan, Rory Johnson, Christophe Hitte, Gilles Salbert, Agnès Méreau, Pascale Quignon, Thomas Derrien, Catherine André
Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are particularly affected by such neuropathies. Clinical signs appear in young puppies and consist of acral analgesia, with or without sudden intense licking, biting and severe self-mutilation of the feet, whereas proprioception, motor abilities and spinal reflexes remain intact. Through a Genome Wide Association Study (GWAS) with 24 affected and 30 unaffected sporting dogs using the Canine HD 170K SNP array (Illumina), we identified a 1...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/28026870/vulvar-and-vaginal-melanoma-a-unique-subclass-of-mucosal-melanoma-based-on-a-comprehensive-molecular-analysis-of-51-cases-compared-with-2253-cases-of-nongynecologic-melanoma
#13
June Y Hou, Caitlin Baptiste, Radhika Bangalore Hombalegowda, Ana I Tergas, Rebecca Feldman, Nathaniel L Jones, Sudeshna Chatterjee-Paer, Ama Bus-Kwolfski, Jason D Wright, William M Burke
BACKGROUND: Optimal treatments for vulvar and vaginal melanomas (VVMs) have not been identified. Herein, the authors compare molecular profiles between VVM and nongynecologic melanoma (NGM) subtypes with the objective of identifying novel, targetable biomarkers. METHODS: In total, 2304 samples of malignant melanoma that were submitted to Caris Life Sciences between 2009 and 2015 were reviewed. In situ hybridization and immunohistochemistry were used to assess copy numbers and protein expression of selected genes...
December 27, 2016: Cancer
https://www.readbyqxmd.com/read/28012358/cystic-metastatic-lymph-nodes-in-malignant-melanoma-a-case-report
#14
Eralda Mema, Emma Cho, Richard Ha, Bret Taback
Melanoma is a rare type of skin cancer with a high mortality rate. Local invasion and metastatic spread are primarily responsible for the morbidity and mortality of melanoma. While metastatic lesions vary from cystic to solid, cystic metastases can be challenging to diagnose. Up to date, there are only a few published studies that describe cystic metastases in melanoma and other conditions such as lymphoma, squamous cell carcinoma and thyroid papillary carcinoma. We describe a case of cystic metastatic axillary lymph nodes in a patient with subungual acral lentiginous melanoma and the challenges to reaching an accurate diagnosis...
December 15, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/28006883/neutrophilic-dermatosis-of-the-dorsal-hands-a-restrictive-designation-for-an-acral-entity
#15
Miguel Costa-Silva, Ana Pedrosa, Filomena Azevedo, Alberto Mota
In 2000, Galaria et al. proposed the designation neutrophilic dermatosis of the dorsal hands (NDDH). The authors describe a case of NDDH with predominant involvement of the palmar aspect of the hands in a patient suffering from lung cancer, a possible paraneoplastic manifestation. Therefore, the term NDDH is not accurate because palmar manifestations of this dermatosis are also possible.
December 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28002098/superficial-acral-fibromyxoma-of-the-toe-unusual-location-of-the-mixoid-variant
#16
Arianna Lamberti, Clelia Miracco, Michele Fimiani, Pietro Rubegni
Superficial acral fibromyxoma (SAFM) is a rare soft tissue tumor that frequently involves the periungual and subungual regions of acral surfaces. Macroscopically, it appears as a flesh-colored dome-shaped solitary mass; microscopically, it consists of a moderately cellular proliferation of spindle-shaped fibroblast-like cells embedded in a myxocollagenous stroma and arranged in a loose storiform and focally fascicular pattern. The tumor cells are immunoreactive for CD34, epithelial membrane antigen, CD99, and CD10...
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27998165/neutrophilic-dermatosis-of-dorsal-hands-and-legs
#17
Elham Behrangi, Abbas Rasi, Bahamin Attar, Zahra Azizian
We present a case of neutrophilic dermatosis of dorsal hands (NDDH), with lesions on the dorsal part of the hands with pustular features and histologic picture of vasculitis.This case highlights the notion that low dose oral steroid can offer a useful first therapeutic option for NDDH. Interstingly, in this case, a few additional lesions were located on the legs, making it different from some previously described cases of NDDH. As with other authors, we believe that this recently described neutrophilic dermatosis is a localized and acral variant of SS...
December 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27957523/recurrent-acral-angioosteoma-cutis-in-a-pregnant-patient
#18
Allison L Wang, Travis Vandergriff, Divya Srivastava, Rajiv I Nijhawan
No abstract text is available yet for this article.
November 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27938818/acral-manifestations-of-contact-dermatitis
#19
Haider K Bangash, Vesna Petronic-Rosic
Contact dermatitis is a broad term that encompasses both nonimmunologic irritant contact dermatitis (ICD) and immunologically mediated allergic contact dermatitis (ACD). Both ICD and ACD can negatively affect a patient's quality of life and are a source of exorbitant medical and societal costs. Avoidance of inciting irritants and/or allergens and liberal use of emollients or humectants are the cornerstone of therapy. When an allergic cause is suspected, patch testing is highly encouraged. In this contribution, we highlight both the commonalities and differences of acral contact dermatitis as it relates to specific regions of the body...
January 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/27938817/acral-manifestations-of-soft-tissue-tumors
#20
Kristen M Paral, Vesna Petronic-Rosic
This group of biologically diverse entities is united by topographic localization to the hands and feet. Categorizing tumors by body site narrows the differential into a short list of possibilities that can facilitate accurate and rapid diagnosis. The goal of this review is to provide a practical approach to soft tissue tumors of acral locations for clinicians, pathologists, and researchers alike. What ensues in the following text is that tight coupling of the clinical picture and histopathologic findings should produce the correct diagnosis, or at least an abbreviated differential...
January 2017: Clinics in Dermatology
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