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https://www.readbyqxmd.com/read/28224164/multiple-primary-acral-lentiginous-melanoma-on-the-feet-developing-in-lesions-of-nagashima-type-palmoplantar-keratoderma
#1
Akimasa Adachi, Mayumi Komine, Takeo Maekawa, Satoru Murata, Aiko Shiohama, Akiharu Kubo, Mamitaro Ohtsuki
is missing (Short communication).
February 22, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28223769/double-primary-acral-lentiginous-melanoma-of-both-soles
#2
Jae Ho Lee, Youngkyung Lim, You Jin Lee, Ji-Hye Park, Dong-Youn Lee
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28217473/cd34-negative-superficial-acral-fibromyxoma-a-rare-case-report
#3
Reza M Robati, Sahar Dadkhahfar, Azadeh Rakhshan
Superficial acral fibromyxoma (SAF) is a slow growing soft tissue tumor that mainly appears in the acral areas. Here, we report a case of a SAF with distinctive immunophenotype charachteristics. An 18-year-old female was referred to our clinic with the complaint of painless subungual nodule of great toe for a few months. The diagnosis of SAF was made according to histopathology and immunohistochemical (IHC) study, however, the IHC assessment showed positive staining with vimentin, focal reaction with smooth muscle actin, negative reaction with CD34, and positive staining pattern with CD99...
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28216303/superficial-acral-fibromyxoma-a-rare-soft-tissue-tumor
#4
José M Braga, Isabel Bartosch, Helena Baldaia, Isabel Oliveira, Aurea Canelhas, Álvaro Silva
Superficial acral fibromyxoma is a rare clinical entity, first described in 2001. It is a soft tissue tumor with a predilection for the fingers and toes. Since it was described, few cases have been reported. We present a case of an 88-year-old male with a history of a slow-growing lump in his left great toe after local trauma. The patient underwent surgical excision, and pathologic analysis revealed the diagnosis of superficial acral fibromyxoma. Although an unusual diagnosis, surgeons should be aware of this myxoid tumor, which requires complete surgical excision and short-term follow-up to detect recurrence...
February 16, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28212764/combined-epidermal-and-follicular-cell-suspension-as-a-novel-surgical-approach-for-acral-vitiligo
#5
Muhammed Razmi T, Davinder Parsad, Sendhil M Kumaran
No abstract text is available yet for this article.
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28191690/mutational-profiling-of-acral-melanomas-in-korean-populations
#6
Joon Ho Shim, Hyun-Tae Shin, Jiho Park, Ji-Hye Park, Jong-Hee Lee, Jun-Mo Yang, Duk-Hwan Kim, Kee-Taek Jang, Dong-Youn Lee
The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasians populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in the Asian populations is limited. To describe the molecular nature of AM in Korean patients, we performed mutational profilinge of AM and matched normal tissues of in patients. Fifty-one formalin-fixed paraffin-embedded AM samples and 32 matched pairs of from patients' saliva DNA were analyzed by next-generation sequencing...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28187531/cutaneous-melanoma-attributable-to-solar-radiation-in-cali-colombia
#7
Esther de Vries, Julio R Amador, Carlos Javier Rincon, Claudia Uribe, D Maxwell Parkin
Estimating the population attributable fraction (PAF) of melanomas due to sun exposure is challenging as there are no unexposed population nor reliable exposure data. In high incidence countries, a historic cohort of the South Thames cancer registry was used as a minimally exposed population using the formula PAF = (observed incidence-incidence in minimally exposure)/observed incidence. In this study we apply this method, constructing a minimally exposed cohort for Colombia and also using the historical South Thames data, using melanoma incidence data from the population-based cancer registry of Cali, Colombia for the period 1967-2012...
February 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28186494/oscillatory-pattern-of-acral-skin-blood-flow-within-thermoneutral-zone-in-healthy-humans
#8
Maja Elstad, Ilias Zilakos, Tone Bergersen
OBJECTIVE: The acral skin contains arteriovenous anastomoses, which probably is the main part of skin microcirculation for blood flow adjustments and thermoregulation in the thermoneutral zone. The objective was to investigate if an increase in sympathetic activation during cooling influences the oscillatory pattern of acral skin blood flow. APPROACH: We had measurements of bilateral acral skin blood flow (n=12) during lowering of ambient temperature from 32°C to 18°C...
February 10, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28154916/-diagnostics-of-malignant-melanoma-of-the-skin-recommendations-of-the-current-s3-guidelines-on-histology-and-molecular-pathology
#9
C Rose
The updated S3 guidelines on malignant melanoma were established in August 2016. The principles of diagnostics and classification are based on the histopathological results from the primary tumor and if necessary the sentinel lymph nodes. The most important factor for prognosis is the tumor thickness according to Breslow and the detection of sentinel node micrometastases. The surgical safety margin after excision is dependent on the tumor thickness. Furthermore, ulceration of the primary tumor and presence of mitosis in melanomas less than 1 mm in thickness are also considered in the T‑classification...
February 2, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28154879/-18-f-fdg-pet-ct-in-the-detection-of-asymptomatic-malignant-melanoma-recurrence
#10
Ismaheel Lawal, Thabo Lengana, Kehinde Ololade, Tebatso Boshomane, Florette Reyneke, Moshe Modiselle, Mariza Vorster, Mike Sathekge
AIM: To evaluate the diagnostic accuracy of FDG PET/CT in the detection of asymptomatic recurrence in patients with malignant melanoma who have had resection of their primary lesion. We also aimed to determine the pattern and factors predisposing to disease recurrence. METHODS: Patients with malignant melanoma who have had surgical resection of their disease and without any clinical evidence of disease recurrence were followed-up with FDG PET/CT. The diagnostic accuracy of FDG PET/CT, pattern of recurrence and factors predictive of disease recurrence were determined...
February 3, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28150890/further-assessment-of-exome-wide-uvr-footprints-in-melanoma-and-their-possible-relevance
#11
Pamela Mukhopadhyay, James Roberts, Graeme J Walker
C > T substitutions at dipyrimidine sites dominate the melanoma genome. We recently analyzed the exomes of spontaneous and neonatal UVR-induced murine melanomas, noting a dramatic change in the genomic footprint at C > T substitutions in the latter. Here we re-analyzed published exome-wide footprints in human melanomas stratified in terms of likely previous sun exposure. Acral and mucosal melanomas were heterogeneous in terms of base substitution types, but most C > Ts occurred in the context of 3'G, probably resulting from spontaneous deamination of the cytosine...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28134728/marker-protein-expression-combined-with-expression-heterogeneity-is-a-powerful-indicator-of-malignancy-in-acral-lentiginous-melanomas
#12
Fernando Cintra Lopes Carapeto, Andréia Neves Comodo, Andressa Germano, Daiane Pereira Guimarães, Denise Barcelos, Mariana Fernandes, Gilles Landman
PATIENTS AND METHODS: Samples of acral lentiginous melanomas (ALMs) were obtained from the Department of Pathology at Escola Paulista de Medicina-Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. Demographic, clinical, and follow-up data were obtained from the charts of Hospital São Paulo. From 2 tissue microarrays containing 60 nevi and quadruplicate samples of ≥1.0-mm of 49 ALM, sections were stained to evaluate SCF, KIT, BRAF, CYCLIND1, MYC, and PTEN immunohistochemical protein expression...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28128089/thin-melanoma-a-generic-term-including-four-histological-subtypes-of-cutaneous-melanoma
#13
Luca Roncati, Teresa Pusiol, Francesco Piscioli
Today, the scientific community is focusing on the prognostic significance of different histological subtypes of thin melanoma (1). The current staging system for melanoma of the American Joint Committee on Cancer (AJCC) uses Breslow thickness as the primary attribute: melanomas with up to 1 mm thickness is defined as thin, because they present a good prognosis after surgical excision, with a 10-year survival rate of 85-90% in case of a tumor-free margin ≥1 cm (2). There is a significant interaction between mitotic rate and Breslow depth, so the predictive value of the mitotic rate on sentinel lymph node (SLN) positivity can be dependent on Breslow thickness (3)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28123854/telomerase-reverse-transcriptase-tert-promoter-mutations-in-korean-melanoma-patients
#14
Mi Ryung Roh, Kyu-Hyun Park, Kee Yang Chung, Sang Joon Shin, Sun Young Rha, Hensin Tsao
Telomerase reverse transcriptase (TERT) is the reverse transcriptase component of the telomeric complex, which synthesizes terminal DNA to protect chromosomal ends and to maintain genomic integrity. In melanoma, mutation in TERT promoter region is a common event and theses promoter variants have been shown to be associated with increased gene expression, decreased telomere length and poorer outcome. In this study, we determined the frequency of TERT promoter mutation in 88 Korean primary melanoma patients and aimed to see the association of TERT promoter mutation status to other major molecular features, such as BRAF, NRAS, KIT mutations and correlate with clinicopathological features...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28111777/vegetating-candidiasis-a-mimicker-of-squamous-cell-carcinoma-in-keratitis-ichthyosis-deafness-syndrome
#15
Ximena Calderón-Castrat, Julio Vega-Zuñiga, Felipe Velásquez, Rosalía Ballona
Keratitis ichthyosis deafness (KID) syndrome is a rare genodermatosis with a high risk of cutaneous malignancy and infections. Infections can induce pseudocarcinomatous epidermal hyperplasia, leading to erroneous diagnosis of squamous cell carcinoma. We present a pediatric case of KID syndrome with vegetating plantar and acral candidiasis and highlight the importance of correct biopsy technique and clinicopathologic correlation in appropriate management.
January 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28107203/clinicopathological-significance-of-intratumoral-and-peritumoral-lymphocytes-and-lymphocyte-score-based-on-the-histologic-subtypes-of-cutaneous-melanoma
#16
Cheol Keun Park, Sang Kyum Kim
The presence of tumor infiltrating lymphocytes is a favorable prognostic factor in cutaneous melanoma, but their clinicopathological significance in the intratumoral compartment compared to the peritumoral compartment is unclear. We investigated the clinicopathologic significance of tumor-infiltrating lymphocytes and lymphocyte score in intra- and peritumoral compartments in 177 Korean patients who had undergone surgical excision of cutaneous melanoma. No significant correlation was observed between various clinicopathologic factors and the presence of intratumoral lymphocytes...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28101024/bazex-syndrome-in-lung-squamous-cell-carcinoma-high-expression-of-epidermal-growth-factor-receptor-in-lesional-keratinocytes-with-th2-immune-shift
#17
Maki Amano, Takaaki Hanafusa, Sakiko Chikazawa, Makiko Ueno, Takeshi Namiki, Ken Igawa, Keiko Miura, Hiroo Yokozeki
An 82-year-old Japanese man was referred for detailed examination of hyperkeratotic erythematous plaques on his palms and soles for 6 months. Two weeks before his first visit, he had undergone lung lobectomy for right lung squamous cell carcinoma (SCC). Laboratory findings showed elevations of eosinophil counts, serum IgE, thymus and activation-regulated chemokine, SCC antigen, and soluble interleukin-2 receptor levels. Histological results of a skin biopsy involving the left palm showed psoriasiform dermatitis...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#18
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28092366/malignant-melanoma-of-sun-protected-sites-a-review-of-clinical-histological-and-molecular-features
#19
Emily A Merkel, Pedram Gerami
In most cases of cutaneous melanoma, ultraviolet (UV) radiation is recognized as a prominent risk factor. Less is known regarding the mechanisms of mutagenesis for melanoma arising in sun-protected sites, such as acral and mucosal melanoma. Acral and mucosal melanoma share many common features, including a late age of onset, a broad radial growth phase with prominent lentiginous growth, the presence of field cancerization cells, and, in most cases, lack of a precursor nevus. In addition to early chromosomal instability, many of the same genes are also involved in these two distinct melanoma subtypes...
January 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28087024/acral-melanoma
#20
Flavia Persechino, Caterina Longo, Elisa Benati, Stefania Borsari, Mara Lombardi, Simonetta Piana, Giuseppe Argenziano, Elvira Moscarella
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
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