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https://www.readbyqxmd.com/read/28107658/validation-of-a-personalized-curved-muscle-model-of-the-lumbar-spine-during-complex-dynamic-exertions
#1
Jaejin Hwang, Gregory G Knapik, Jonathan S Dufour, Thomas M Best, Safdar N Khan, Ehud Mendel, William S Marras
Previous curved muscle models have typically examined their robustness only under simple, single-plane static exertions. In addition, the empirical validation of curved muscle models through an entire lumbar spine has not been fully realized. The objective of this study was to empirically validate a personalized biologically-assisted curved muscle model during complex dynamic exertions. Twelve subjects performed a variety of complex lifting tasks as a function of load weight, load origin, and load height. Both a personalized curved muscle model as well as a straight-line muscle model were used to evaluate the model's fidelity and prediction of three-dimensional spine tissue loads under different lifting conditions...
January 9, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28107137/interprofessional-education-in-an-orthodontic-outreach-training-centre
#2
Richard Cure
Interprofessional education (IPE) describes those occasions when students from two or more professions learn about, from and with each other to enable effective collaboration and improve health outcomes. In the UK, orthodontic treatment is now delivered by a highly skilled team. Historically, education and training for orthodontic team members has been delivered 'uniprofessionally' in secondary care hospital settings, despite 96% of dental care, including orthodontics, being delivered in primary care. This paper describes an evaluation of IPE in Leamington Spa Orthodontics (LSO), a University-approved, primary care outreach training centre, where all members of the orthodontic team deliver patient care and are educated together in an IPE environment...
November 1, 2016: Primary Dental Journal
https://www.readbyqxmd.com/read/28106764/effective-alternating-direction-optimization-methods-for-sparsity-constrained-blind-image-deblurring
#3
Naixue Xiong, Ryan Wen Liu, Maohan Liang, Di Wu, Zhao Liu, Huisi Wu
Single-image blind deblurring for imaging sensors in the Internet of Things (IoT) is a challenging ill-conditioned inverse problem, which requires regularization techniques to stabilize the image restoration process. The purpose is to recover the underlying blur kernel and latent sharp image from only one blurred image. Under many degraded imaging conditions, the blur kernel could be considered not only spatially sparse, but also piecewise smooth with the support of a continuous curve. By taking advantage of the hybrid sparse properties of the blur kernel, a hybrid regularization method is proposed in this paper to robustly and accurately estimate the blur kernel...
January 18, 2017: Sensors
https://www.readbyqxmd.com/read/28104073/af-ablation-guided-by-spatiotemporal-electrogram-dispersion%C3%A2-without-pulmonary-vein-isolation-a-wholly-patient-tailored-approach
#4
Julien Seitz, Clément Bars, Guillaume Théodore, Sylvain Beurtheret, Nicolas Lellouche, Michel Bremondy, Ange Ferracci, Jacques Faure, Guillaume Penaranda, Masatoshi Yamazaki, Uma Mahesh R Avula, Laurence Curel, Sabrina Siame, Omer Berenfeld, André Pisapia, Jérôme Kalifa
BACKGROUND: The use of intracardiac electrograms to guide atrial fibrillation (AF) ablation has yielded conflicting results. OBJECTIVES: The authors evaluated the usefulness of spatiotemporal dispersion, a visually recognizable electric footprint of AF drivers, for the ablation of all forms of AF. METHODS: The authors prospectively enrolled 105 patients admitted for AF ablation. AF was sequentially mapped in both atria with a 20-pole PentaRay catheter...
January 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28102001/evaluation-of-the-hybrid-resolution-pace-model-for-the-study-of-folding-insertion-and-pore-formation-of-membrane-associated-peptides
#5
Michael D Ward, Shivangi Nangia, Eric R May
The PACE force field presents an attractive model for conducting molecular dynamics simulations of membrane-protein systems. PACE is a hybrid model, in which lipids and solvents are coarse-grained consistent with the MARTINI mapping, while proteins are described by a united atom model. However, given PACE is linked to MARTINI, which is widely used to study membranes, the behavior of proteins interacting with membranes has only been limitedly examined in PACE. In this study, PACE is used to examine the behavior of several peptides in membrane environments, namely WALP peptides, melittin and influenza hemagglutinin fusion peptide (HAfp)...
January 19, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28100040/induced-pluripotent-stem-cell-research-in-the-era-of-precision-medicine
#6
Takashi Hamazaki, Nihal El Rouby, Natalie C Fredette, Katherine E Santostefano, Naohiro Terada
Recent advances in DNA sequencing technologies are revealing how human genetic variations associate with differential health risks, disease susceptibilities and drug responses. Such information is now expected to help evaluate individual health risks, design personalized health plans and treat patients with precision. It is still challenging, however, to understand how such genetic variations cause the phenotypic alterations in pathobiologies and treatment response. Human induced pluripotent stem cell (iPSC) technologies are emerging as a promising strategy to fill the knowledge gaps between genetic association studies and underlying molecular mechanisms...
January 18, 2017: Stem Cells
https://www.readbyqxmd.com/read/28097504/estimating-the-relative-weights-of-visual-and-auditory-tau-versus-heuristic-based-cues-for-time-to-contact-judgments-in-realistic-familiar-scenes-by-older-and-younger-adults
#7
Behrang Keshavarz, Jennifer L Campos, Patricia R DeLucia, Daniel Oberfeld
Estimating time to contact (TTC) involves multiple sensory systems, including vision and audition. Previous findings suggested that the ratio of an object's instantaneous optical size/sound intensity to its instantaneous rate of change in optical size/sound intensity (τ) drives TTC judgments. Other evidence has shown that heuristic-based cues are used, including final optical size or final sound pressure level. Most previous studies have used decontextualized and unfamiliar stimuli (e.g., geometric shapes on a blank background)...
January 17, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28095991/assessing-environmental-impacts-of-genetically-modified-plants-on-non-target-organisms-the-relevance-of-in-planta-studies
#8
REVIEW
Salvatore Arpaia, A Nicholas E Birch, Jozsef Kiss, Joop J A van Loon, Antoine Messéan, Marco Nuti, Joe N Perry, Jeremy B Sweet, Christoph C Tebbe
In legal frameworks worldwide, genetically modified plants (GMPs) are subjected to pre-market environmental risk assessment (ERA) with the aim of identifying potential effects on the environment. In the European Union, the EFSA Guidance Document introduces the rationale that GMPs, as well as their newly produced metabolites, represent the potential stressor to be evaluated during ERA. As a consequence, during several phases of ERA for cultivation purposes, it is considered necessary to use whole plants or plant parts in experimental protocols...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28095405/defining-the-risk-of-zika-and-chikungunya-virus-transmission-in-human-population-centers-of-the-eastern-united-states
#9
Carrie A Manore, Richard S Ostfeld, Folashade B Agusto, Holly Gaff, Shannon L LaDeau
The recent spread of mosquito-transmitted viruses and associated disease to the Americas motivates a new, data-driven evaluation of risk in temperate population centers. Temperate regions are generally expected to pose low risk for significant mosquito-borne disease; however, the spread of the Asian tiger mosquito (Aedes albopictus) across densely populated urban areas has established a new landscape of risk. We use a model informed by field data to assess the conditions likely to facilitate local transmission of chikungunya and Zika viruses from an infected traveler to Ae...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28092464/expectations-for-treatment-in-pediatric-weight-management-and-relationship-to-attrition
#10
Erinn T Rhodes, Richard E Boles, Kimberly Chin, Amy Christison, Elizabeth Getzoff Testa, Kimberly Guion, Mary Jane Hawkins, Carter R Petty, Bethany Sallinen Gaffka, Melissa Santos, Laura Shaffer, Jared Tucker, Sarah E Hampl
BACKGROUND: Attrition in pediatric weight management negatively impacts treatment outcomes. A potentially modifiable contributor to attrition is unmet family expectations. This study aimed to evaluate the association between adolescent and parent/guardian treatment expectations and attrition. PATIENTS AND METHODS: A prospective, nonrandomized, uncontrolled, single-arm pilot trial was conducted among 12 pediatric weight management programs in the Children's Hospital Association's FOCUS on a Fitter Future collaborative...
January 16, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28089582/a-model-for-screening-and-prioritizing-consumer-nanoproduct-risks-a-case-study-from-south-africa
#11
Ndeke Musee
The potential risks of the increasing variety and volume of engineered nanomaterials (ENMs) entering into the ecosystem remain poorly quantified. In recent years, information essential to evaluate the ecological risks of ENMs has increased. However, the data are highly fragmented, limited, or severely lacking. This limits the usefulness of the information to support holistic screening and prioritization of potentially harmful ENMs. To screen and prioritize ENMs risks, we adopted a two-phased approach. First, a holistic framework model was developed to integrate a diverse set of factors aimed to assess the potential hazard, exposure, and in turn, risk to the ecosystem of ENMs from a given consumer nanoproduct...
January 12, 2017: Environment International
https://www.readbyqxmd.com/read/28089562/sequential-multiple-assignment-randomized-trials-an-opportunity-for-improved-design-of-stroke-reperfusion-trials
#12
William J Meurer, Nicholas J Seewald, Kelley Kidwell
BACKGROUND: Modern clinical trials in stroke reperfusion fall into 2 categories: alternative systemic pharmacological regimens to alteplase and "rescue" endovascular approaches using targeted thrombectomy devices and/or medications delivered directly for persistently occluded vessels. Clinical trials in stroke have not evaluated how initial pharmacological thrombolytic management might influence subsequent rescue strategy. A sequential multiple assignment randomized trial (SMART) is a novel trial design that can test these dynamic treatment regimens and lead to treatment guidelines that more closely mimic practice...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28077414/implementation-of-a-consumer-focused-ehealth-intervention-for-people-with-moderate-to-high-cardiovascular-disease-risk-protocol-for-a-mixed-methods-process-evaluation
#13
Genevieve M Coorey, Lis Neubeck, Timothy Usherwood, David Peiris, Sharon Parker, Annie Y S Lau, Clara Chow, Kathryn Panaretto, Mark Harris, Nicholas Zwar, Julie Redfern
INTRODUCTION: Technology-mediated strategies have potential to engage patients in modifying unhealthy behaviour and improving medication adherence to reduce morbidity and mortality from cardiovascular disease (CVD). Furthermore, electronic tools offer a medium by which consumers can more actively navigate personal healthcare information. Understanding how, why and among whom such strategies have an effect can help determine the requirements for implementing them at a scale. This paper aims to detail a process evaluation that will (1) assess implementation fidelity of a multicomponent eHealth intervention; (2) determine its effective features; (3) explore contextual factors influencing and maintaining user engagement; and (4) describe barriers, facilitators, preferences and acceptability of such interventions...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28076361/synergy-and-order-effects-of-antibiotics-and-phages-in-killing-pseudomonas-aeruginosa-biofilms
#14
Waqas Nasir Chaudhry, Jeniffer Concepción-Acevedo, Taehyun Park, Saadia Andleeb, James J Bull, Bruce R Levin
In contrast to planktonic cells, bacteria imbedded biofilms are notoriously refractory to treatment by antibiotics or bacteriophage (phage) used alone. Given that the mechanisms of killing differ profoundly between drugs and phages, an obvious question is whether killing is improved by combining antibiotic and phage therapy. However, this question has only recently begun to be explored. Here, in vitro biofilm populations of Pseudomonas aeruginosa PA14 were treated singly and with combinations of two phages and bactericidal antibiotics of five classes...
2017: PloS One
https://www.readbyqxmd.com/read/28073339/dermal-safety-assessment-of-arm-hammer-laundry-products-formulated-for-sensitive-skin
#15
Douglas M Frederick, Linda Vorwerk, Archana Gupta, Annahita Ghassemi
CONTEXT: The prevalence of sensitive skin among the general population in industrialized countries is reported to be over 50%. Sensitive skin subjects often report significant reactions to contact with cosmetics, soaps and other consumer products. OBJECTIVE: This paper describes the overall skin compatibility and mildness program for a newly developed, lightly fragranced, colorant free laundry product (i.e. Arm & Hammer™ Sensitive Skin plus Skin-Friendly Fresh Scent), specially formulated for individuals with sensitive skin...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28069627/what-aspects-of-intentional-rounding-work-in-hospital-wards-for-whom-and-in-what-circumstances-a-realist-evaluation-protocol
#16
Ruth Harris, Sarah Sims, Ros Levenson, Stephen Gourlay, Fiona Ross Cbe, Nigel Davies, Sally Brearley, Giampiero Favato, Robert Grant
INTRODUCTION: Intentional rounding (IR) is a structured process whereby nurses in hospitals carry out regular checks, usually hourly, with individual patients using a standardised protocol to address issues of positioning, pain, personal needs and placement of items. The widespread implementation of IR across the UK has been driven by the recommendations of the Francis Inquiry although empirical evidence of its effectiveness is poor. This paper presents a protocol of a multimethod study using a realist evaluation approach to investigate the impact and effectiveness of IR in hospital wards on the organisation, delivery and experience of care from the perspective of patients, their family members and staff...
January 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28068885/a-methodical-approach-for-the-assessment-of-waste-sorting-plants
#17
Alexander Feil, Thomas Pretz, Philipp Vitz, Eggo Ulphard Thoden van Velzen
A techno-economical evaluation of the processing result of waste sorting plants should at least provide a realistic assessment of the recovery yields of valuable materials and of the qualities of the obtained products. This practical data is generated by weighing all the output products and sampling these products. Due to the technological complexity of sorting plants, for example, lightweight packaging waste treatments plants and the high expenditures concerning time and costs of sampling with subsequent manual sorting for quality determination, usually only final products undergo such an investigation...
January 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28066888/technical-note-a-new-zeolite-pet-phantom-to-test-segmentation-algorithms-on-heterogeneous-activity-distributions-featured-with-ground-truth-contours
#18
Chiara D Soffientini, Elisabetta De Bernardi, Rosangela Casati, Giuseppe Baselli, Felicia Zito
PURPOSE: Design, realization, scan, and characterization of a phantom for PET Automatic Segmentation (PET-AS) assessment are presented. Radioactive zeolites immersed in a radioactive heterogeneous background simulate realistic wall-less lesions with known irregular shape and known homogeneous or heterogeneous internal activity. METHOD: Three different zeolite families were evaluated in terms of radioactive uptake homogeneity, necessary to define activity and contour ground truth...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28061368/modeling-of-the-photoplethysmogram-during-atrial-fibrillation
#19
Andrius Sološenko, Andrius Petrėnas, Vaidotas Marozas, Leif Sörnmo
A phenomenological model for simulating the photoplethysmogram (PPG) during atrial fibrillation (AF) is proposed. The simulated PPG is solely based on RR interval information, and, therefore, any annotated ECG database can be used to model sinus rhythm, AF, or rhythms with premature beats. A PPG pulse is modeled by a linear combination of a log-normal and two Gaussian waveforms. The model PPG is obtained by placing individual pulses according to the RR intervals so that a connected signal is created. The model is evaluated on synchronously recorded ECG and PPG signals from the MIMIC and the University of Queensland Vital Signs Dataset databases...
December 28, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28059905/functional-tricuspid-regurgitation-model-in-a-beating-heart-platform
#20
Michal Jaworek, Marco Piola, Federico Lucherini, Guido Gelpi, Marco Castagna, Giuliana Lentini, Carlo Antona, Gianfranco B Fiore, Riccardo Vismara
Currently, clinicians are seeking new, minimally invasive treatment options for functional tricuspid regurgitation (FTR). Challenging tricuspid complexity requires the evaluation of the treatment techniques in adequate and realistic preclinical scenario. The purpose of this paper is to describe the design and functional assessment of a novel passive beating heart model of the pulmonary circulation with the possibility to tightly control FTR.The model housed porcine hearts actuated by a volumetric pump that cyclically pressurized the right ventricle...
January 3, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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