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Realistic evaluation

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https://www.readbyqxmd.com/read/29245004/a-standardized-preoperative-group-intervention-is-feasible-and-acceptable-to-orthognathic-surgery-patients
#1
Xialong Li, Debra L Safer, Imilce Castro Paz, Roseanne Menorca, Sabine Girod
PURPOSE: Nearly 10% of patients remain dissatisfied after orthognathic surgery, largely because of psychoeducational or psychosocial factors. The purpose of this study was to evaluate the feasibility and acceptability of a psychoeducationally based group intervention to improve preoperative preparation of orthognathic surgical patients and their caregivers. MATERIALS AND METHODS: The intervention consisted of 2 group sessions, with each session lasting 2 hours...
November 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29244762/towards-realistic-urban-traffic-experiments-using-dfrouter-heuristic-validation-and-extensions
#2
Jorge Luis Zambrano-Martinez, Carlos T Calafate, David Soler, Juan-Carlos Cano
Traffic congestion is an important problem faced by Intelligent Transportation Systems (ITS), requiring models that allow predicting the impact of different solutions on urban traffic flow. Such an approach typically requires the use of simulations, which should be as realistic as possible. However, achieving high degrees of realism can be complex when the actual traffic patterns, defined through an Origin/Destination (O-D) matrix for the vehicles in a city, remain unknown. Thus, the main contribution of this paper is a heuristic for improving traffic congestion modeling...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29242568/automatic-multiple-zebrafish-larvae-tracking-in-unconstrained-microscopic-video-conditions
#3
Xiaoying Wang, Eva Cheng, Ian S Burnett, Yushi Huang, Donald Wlodkowic
The accurate tracking of zebrafish larvae movement is fundamental to research in many biomedical, pharmaceutical, and behavioral science applications. However, the locomotive characteristics of zebrafish larvae are significantly different from adult zebrafish, where existing adult zebrafish tracking systems cannot reliably track zebrafish larvae. Further, the far smaller size differentiation between larvae and the container render the detection of water impurities inevitable, which further affects the tracking of zebrafish larvae or require very strict video imaging conditions that typically result in unreliable tracking results for realistic experimental conditions...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29240557/impact-of-motion-compensation-and-partial-volume-correction-for-18f-naf-pet-ct-imaging-of-coronary-plaque
#4
J Cal-González, C Tsoumpas, M L Lassen, S Rasul, L Koller, M Hacker, K Schäfers, T Beyer
Recent studies have suggested that 18F-NaF-PET enables visualization and quantification of plaque micro-calcification in the coronary tree. However, PET imaging of plaque calcification in the coronary arteries is challenging because of the respiratory and cardiac motion as well as partial volume effects. The objective of this work is to implement an image reconstruction framework, which incorporates compensation for respiratory as well as cardiac motion (MoCo) and partial volume correction (PVC), for cardiac 18F-NaF PET imaging in PET/CT...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29239532/a-3d-real-scale-biomimetic-and-biohybrid-model-of-the-blood-brain-barrier-fabricated-through-two-photon-lithography
#5
Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
The investigation of the crossing of exogenous substances through the blood-brain barrier (BBB) is object of intensive research in biomedicine, and one of the main obstacles for reliable in vitro evaluations is represented by the difficulties at the base of developing realistic models of the barrier, which could resemble as most accurately as possible the in vivo environment. Here, for the first time, a 1:1 scale, biomimetic, and biohybrid BBB model is proposed. Microtubes inspired to the brain capillaries were fabricated through two-photon lithography and used as scaffolds for the co-culturing of endothelial-like bEnd...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29238828/validation-of-the-strain-assessment-of-an-abdominal-phantom-aortic-aneurysm-comparison-of-results-obtained-from-magnetic-resonance-imaging-measurements-and-stereovision-measurements
#6
Yufei Wang, David Joannic, Patrick Juillion, Aurélien Monnet, Patrick Delassus, Alain Lalande, Jean-Francois Fontaine
Predicating aortic aneurysm ruptures is a complex problem that has been investigated by many research teams over several decades. Work on this issue is notably complex and involves both the mechanical behavior of the artery and the blood flow. Magnetic resonance imaging (MRI) can provide measurements concerning the shape of an organ and the blood that flows through it. Measuring local distortion of the artery wall is the first essential element to evaluate a ruptured artery. This paper aims to demonstrate the feasibility of this measure by MRI on phantom realistic abdominal aortic aneurysm (AAA)...
December 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29237463/the-researchers-role-in-knowledge-translation-a-realist-evaluation-of-the-development-and-implementation-of-diagnostic-pathways-for-cancer-in-two-united-kingdom-localities
#7
Jon Banks, Lesley Wye, Nicola Hall, James Rooney, Fiona M Walter, Willie Hamilton, Ardiana Gjini, Greg Rubin
BACKGROUND: In examining an initiative to develop and implement new cancer diagnostic pathways in two English localities, this paper evaluates 'what works' and examines the role of researchers in facilitating knowledge translation amongst teams of local clinicians and policy-makers. METHODS: Using realist evaluation with a mixed methods case study approach, we conducted documentary analysis of meeting minutes and pathway iterations to map pathway development. We interviewed 14 participants to identify the contexts, mechanisms and outcomes (CMOs) that led to successful pathway development and implementation...
December 13, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29236975/indecut-evaluates-performance-of-network-motif-discovery-algorithms
#8
Mitra Ansariola, Molly Megraw, David Koslicki
Motivation: Genomic networks represent a complex map of molecular interactions which are descriptive of the biological processes occurring in living cells. Identifying the small over-represented circuitry patterns in these networks helps generate hypotheses about the functional basis of such complex processes. Network motif discovery is a systematic way of achieving this goal. However, a reliable network motif discovery outcome requires generating random background networks which are the result of a uniform and independent graph sampling method...
December 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29236726/demographic-monitoring-of-wild-muriqui-populations-criteria-for-defining-priority-areas-and-monitoring-intensity
#9
Karen B Strier, Carla B Possamai, Fernanda P Tabacow, Alcides Pissinatti, Andre M Lanna, Fabiano Rodrigues de Melo, Leandro Moreira, Maurício Talebi, Paula Breves, Sérgio L Mendes, Leandro Jerusalinsky
Demographic data are essential to assessments of the status of endangered species. However, establishing an integrated monitoring program to obtain useful data on contemporary and future population trends requires both the identification of priority areas and populations and realistic evaluations of the kinds of data that can be obtained under different monitoring regimes. We analyzed all known populations of a critically endangered primate, the muriqui (genus: Brachyteles) using population size, genetic uniqueness, geographic importance (including potential importance in corridor programs) and implementability scores to define monitoring priorities...
2017: PloS One
https://www.readbyqxmd.com/read/29235986/managing-diabetes-in-people-with-dementia-a-realist-review
#10
Frances Bunn, Claire Goodman, Peter Reece Jones, Bridget Russell, Daksha Trivedi, Alan Sinclair, Antony Bayer, Greta Rait, Jo Rycroft-Malone, Chris Burton
BACKGROUND: Dementia and diabetes mellitus are common long-term conditions that coexist in a large number of older people. People living with dementia and diabetes may be at increased risk of complications such as hypoglycaemic episodes because they are less able to manage their diabetes. OBJECTIVES: To identify the key features or mechanisms of programmes that aim to improve the management of diabetes in people with dementia and to identify areas needing further research...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29235449/evaluation-of-skin-absorbed-doses-during-manipulation-of-radioactive-sources-a-comparison-between-varskin-code-and-monte-carlo-simulations
#11
Ernesto Amato, Antonio Italiano
The evaluation of skin doses during manipulation of radioactive sources can be a critical issue, worth using the most accurate calculation strategies available. The aim of this work was to compare the results of the analytical approach used in VARSKIN with the simulation of radiation transport and interaction by Monte Carlo calculations in GAMOS (GEANT4-based Architecture for Medicine-Oriented Simulations), and to provide an accurate and versatile tool for the evaluation of skin doses from radionuclide sources of any realistic shape (e...
December 13, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29234892/how-accurate-is-the-description-of-ligand-protein-interactions-by-a-hybrid-qm-mm-approach
#12
Jakub Kollar, Vladimir Frecer
During the last decades, the application of hybrid quantum mechanical/molecular mechanical (QM/MM) methods has been extended to the field of drug design. In principle, the approximate QM/MM approach offers a more complete description of drug-receptor non-covalent interactions. This is especially true when charge or proton transfer, chelation of metal ions or strong polarization of ligand and protein or surface chemical groups are involved. The aim of this work was to assess the accuracy of calculated non-covalent ligand-protein interaction energies ([Formula: see text]) obtained by the hybrid QM/MM approach employed in QSite/Jaguar of Schrödinger's Small-Molecule Drug Discovery Suite on a set of small-molecule model systems when compared to rigorous QM calculations...
December 12, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29234553/gait-deficits-under-dual-task-conditions-in-the-concussed-adolescent-and-young-athlete-population-a-systematic-review
#13
Larisa Grants, Bailey Powell, Cody Gessel, Faith Hiser, Amy Hassen
Background: There are no current sport concussion assessments that capture the effects of dual-task conditions on gait. Multiple studies have evaluated changes, but none have comprehensively examined literature related to the adolescent and young adult population.Purpose: The purpose of this systematic review is to synthesize documented changes in gait under dual-task conditions in adolescents and young adults after sustaining a concussion.Study Design: Systematic Review. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was consulted to guide this systematic review...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29233930/critical-research-gaps-and-recommendations-to-inform-research-prioritisation-for-more-effective-prevention-and-improved-outcomes-in-colorectal-cancer
#14
REVIEW
Mark Lawler, Deborah Alsina, Richard A Adams, Annie S Anderson, Gina Brown, Nicola S Fearnhead, Stephen W Fenwick, Stephen P Halloran, Daniel Hochhauser, Mark A Hull, Viktor H Koelzer, Angus G K McNair, Kevin J Monahan, Inke Näthke, Christine Norton, Marco R Novelli, Robert J C Steele, Anne L Thomas, Lisa M Wilde, Richard H Wilson, Ian Tomlinson
OBJECTIVE: Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. DESIGN: RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC...
January 2018: Gut
https://www.readbyqxmd.com/read/29233320/the-description-and-evaluation-of-virtual-worlds-in-clinical-pharmacy-education-in-northern-sweden
#15
Maria Gustafsson, Claire Englund, Gisselle Gallego
BACKGROUND AND PURPOSE: The purpose of this article is to describe and evaluate the use of a three-dimensional virtual world (3DVW) in a clinical pharmacy course. EDUCATIONAL ACTIVITY AND SETTING: Students are provided with training opportunities in simulated ward rounds and patient meetings in a 3DVW. The 3DVW enables students to practice communication with patients and colleagues in a professional manner. To evaluate the course and use of the 3DVW, an online course evaluation was completed by students after they had finished the clinical pharmacy course...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29226139/stochastic-dosimetry-for-the-assessment-of-children-exposure-to-uniform-50%C3%A2-hz-magnetic-field-with-uncertain-orientation
#16
E Chiaramello, S Fiocchi, P Ravazzani, M Parazzini
This study focused on the evaluation of the exposure of children aging from five to fourteen years to 50 Hz homogenous magnetic field uncertain orientation using stochastic dosimetry. Surrogate models allowed assessing how the variation of the orientation of the magnetic field influenced the induced electric field in each tissue of the central nervous system (CNS) and in the peripheral nervous system (PNS) of children. Results showed that the electric field induced in CNS and PNS tissues of children were within the ICNIRP basic restrictions for general public and that no significant difference was found in the level of exposure of children of different ages when considering 10000 possible orientations of the magnetic field...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225949/improving-postpartum-care-delivery-and-uptake-by-implementing-context-specific-interventions-in-four-countries-in-africa-a-realist-evaluation-of-the-missed-opportunities-in-maternal-and-infant-health-momi-project
#17
Nehla Djellouli, Sue Mann, Bejoy Nambiar, Paula Meireles, Diana Miranda, Henrique Barros, Fadima Y Bocoum, W Maurice E Yaméogo, Clarisse Yaméogo, Sylvie Belemkoabga, Halima Tougri, Abou Coulibaly, Seni Kouanda, Vernon Mochache, Omar K Mwakusema, Eunice Irungu, Peter Gichangi, Zione Dembo, Angela Kadzakumanja, Charles Vidonji Makwenda, Judite Timóteo, Misete G Cossa, Malica de Melo, Sally Griffin, Nafissa B Osman, Severiano Foia, Emilomo Ogbe, Els Duysburgh, Tim Colbourn
Postpartum care (PPC) has remained relatively neglected in many interventions designed to improve maternal and neonatal health in sub-Saharan Africa. The Missed Opportunities in Maternal and Infant Health project developed and implemented a context-specific package of health system strengthening and demand generation in four African countries, aiming to improve access and quality of PPC. A realist evaluation was conducted to enable nuanced understanding of the influence of different contextual factors on both the implementation and impacts of the interventions...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225938/health-sector-governance-should-we-be-investing-more
#18
REVIEW
Robert Fryatt, Sara Bennett, Agnes Soucat
Governance is central to improving health sector performance and achieving Universal Health Coverage (UHC). However, the growing body of research on governance and health has not yet led to a global consensus on the need for more investment in governance interventions to improve health. This paper aims to summarise the latest evidence on the influence of governance on health, examines how we can assess governance interventions and considers what might constitute good investments in health sector governance in resource constrained settings...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29223660/developing-nursing-and-midwifery-students-capacity-for-coping-with-bullying-and-aggression-in-clinical-settings-students-evaluation-of-a-learning-resource
#19
Rosemarie Hogan, Fiona Orr, Deborah Fox, Allison Cummins, Maralyn Foureur
An innovative blended learning resource for undergraduate nursing and midwifery students was developed in a large urban Australian university, following a number of concerning reports by students on their experiences of bullying and aggression in clinical settings. The blended learning resource included interactive online learning modules, comprising film clips of realistic clinical scenarios, related readings, and reflective questions, followed by in-class role-play practice of effective responses to bullying and aggression...
December 6, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29222277/how-should-we-sequence-and-combine-novel-therapies-in-cll
#20
REVIEW
Matthew S Davids
With the recent approval of several effective and well-tolerated novel agents (NAs), including ibrutinib, idelalisib, venetoclax, and obinutuzumab, patients with chronic lymphocytic leukemia (CLL) have more therapeutic options than ever before. The availability of these agents is both an important advance for patients but also a challenge for practicing hematologist/oncologists to learn how best to sequence NAs, both with respect to chemoimmunotherapy (CIT) and to other NAs. The sequencing of NAs in clinical practice should be guided both by an individual patient's prognostic markers, such as FISH and immunoglobulin heavy chain variable region (IGHV)-mutation status, as well as the patient's medical comorbidities and goals of care...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
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