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https://www.readbyqxmd.com/read/29141062/management-of-severe-acne-vulgaris-with-topical-therapy
#1
Linda Stein Gold, Hilary E Baldwin, Tina Lin
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combination topical therapies to treat severe acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140991/a-bayesian-method-for-detecting-pairwise-associations-in-compositional-data
#2
Emma Schwager, Himel Mallick, Steffen Ventz, Curtis Huttenhower
Compositional data consist of vectors of proportions normalized to a constant sum from a basis of unobserved counts. The sum constraint makes inference on correlations between unconstrained features challenging due to the information loss from normalization. However, such correlations are of long-standing interest in fields including ecology. We propose a novel Bayesian framework (BAnOCC: Bayesian Analysis of Compositional Covariance) to estimate a sparse precision matrix through a LASSO prior. The resulting posterior, generated by MCMC sampling, allows uncertainty quantification of any function of the precision matrix, including the correlation matrix...
November 15, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29140783/blending-face-details-synthesizing-a-face-using-multiscale-face-models
#3
Seung-Hyun Yoon, John Lewis, Taehyun Rhee
Creating realistic 3D face models is a challenging problem in computer graphics because humans are so sensitive to facial abnormalities. The authors propose a method to synthesize a 3D face model using weighted blending of multiscale details from different face models. Using multiscale continuous displacement maps (CDMs), they achieve full correspondences across multiple scales in the parameter space. Their results demonstrate detail transfer across faces with highly different proportions, such as between humans and nonhuman creatures...
November 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/29139613/nipple-sparing-mastectomy-as-treatment-for-patients-with-ductal-carcinoma-in%C3%A2-situ-a-10-year-follow-up-study
#4
Víctor Lago, Vincenzo Maisto, Julia Gimenez-Climent, Jose Vila, Carlos Vazquez, Rafael Estevan
The objective was to determine the 10-year oncological safety of nipple-sparing mastectomy (NSM) in patients diagnosed with ductal carcinoma in situ (DCIS). The use of NSM preserves the nipple-areola complex (NAC). As residual fibroglandular breast tissue can remain behind the spared NAC, its use for patient with breast cancer is controversial. The oncologic outcomes and complication rates after performing NSM compared to other techniques are still under debate and a concern when treating patients with breast cancer...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139529/lab-on-capillary-a-rapid-simple-and-quantitative-genetic-analysis-platform-integrating-nucleic-acid-extraction-amplification-and-detection
#5
Yu Fu, Xiaoming Zhou, Da Xing
In this work, we describe for the first time a genetic diagnosis platform employing a polydiallyldimethylammonium chloride (PDDA)-modified capillary and a liquid-based thermalization system for rapid, simple and quantitative DNA analysis with minimal user interaction. Positively charged PDDA is modified on the inner surface of the silicon dioxide capillary by using an electrostatic self-assembly approach that allows the negatively charged DNA to be separated from the lysate in less than 20 seconds. The capillary loaded with the PCR mix is incorporated in the thermalization system, which can achieve on-site real-time PCR...
November 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29139489/online-monitoring-of-a-photocatalytic-reaction-by-real-time-high-resolution-flownmr-spectroscopy
#6
Andrew M R Hall, Rachael Broomfield-Tagg, Matthew Camilleri, David R Carbery, Anna Codina, David T E Whittaker, Steven Coombes, John P Lowe, Ulrich Hintermair
We demonstrate how FlowNMR spectroscopy can readily be applied to investigate photochemical reactions that require sustained input of light and air to yield mechanistic insight under realistic conditions. The Eosin Y mediated photo-oxidation of N-allylbenzylamine is shown to produce imines as primary reaction products from which undesired aldehydes form after longer reaction times. Facile variation of reaction conditions during the reaction in flow allows for probe experiments that give information about the mode of action of the photocatalyst...
November 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29139286/highly-sensitive-flexible-pressure-sensors-based-on-printed-organic-transistors-with-centro-apically-self-organized-organic-semiconductor-microstructures
#7
So Young Yeo, Sangsik Park, Yeonjin Yi, Do Hwan Kim, Jung Ah Lim
A highly sensitive pressure sensor based on a printed organic transistors with three-dimensionally self-organized organic semiconductor microstructures were demonstrated. A unique organic transistor with semiconductor channels positioned at the highest summit of printed cylindrical microstructures was achieved simply by printing an organic semiconductor and polymer blend on the plastic substrate without the use of additional etching or replication processes. A combination of the printed organic semiconductor microstructure and an elastomeric top-gate dielectric resulted in a highly sensitive OFET pressure sensor with a high pressure sensitivity of 1...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29139075/investigation-of-the-effects-of-slow-release-fertilizer-and-struvite-in-biodegradation-in-filter-drains-and-potential-application-of-treated-water-in-irrigation-of-road-verges
#8
Stephen C Theophilus, Fredrick U Mbanaso, Ernest O Nnadi, Kingsley T Onyedeke
Filter drains are usually laid along the margins of highways. Highway runoffs are polluted with hydrocarbons and high levels of total dissolved solids. Therefore, effective pollution removal mechanism is necessary in order to avoid contamination of surrounding soils and groundwater. Biodegradation is amongst pollution removal mechanisms in filter drains, but it is a relatively slow process which is dependent on wide range of factors including the type of pollutant and availability of nutrients. This paper reports on a study conducted to investigate the impact of slow-release fertilizer and struvite in enhancement of biodegradation of hydrocarbon in filter drains...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29138404/neonicotinoid-pesticide-limits-improvement-in-buzz-pollination-by-bumblebees
#9
P R Whitehorn, C Wallace, M Vallejo-Marin
Neonicotinoid pesticides have been linked to global declines of beneficial insects such as bumblebees. Exposure to trace levels of these chemicals causes sub-lethal effects, such as reduced learning and foraging efficiency. Complex behaviours may be particularly vulnerable to the neurotoxic effects of neonicotinoids. Such behaviours may include buzz pollination (sonication), in which pollinators, usually bees, use innate and learned behaviours to generate high-frequency vibrations to release pollen from flowers with specialised anther morphologies...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138310/sparsity-enables-estimation-of-both-subcortical-and-cortical-activity-from-meg-and-eeg
#10
Pavitra Krishnaswamy, Gabriel Obregon-Henao, Jyrki Ahveninen, Sheraz Khan, Behtash Babadi, Juan Eugenio Iglesias, Matti S Hämäläinen, Patrick L Purdon
Subcortical structures play a critical role in brain function. However, options for assessing electrophysiological activity in these structures are limited. Electromagnetic fields generated by neuronal activity in subcortical structures can be recorded noninvasively, using magnetoencephalography (MEG) and electroencephalography (EEG). However, these subcortical signals are much weaker than those generated by cortical activity. In addition, we show here that it is difficult to resolve subcortical sources because distributed cortical activity can explain the MEG and EEG patterns generated by deep sources...
November 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29137728/a-computational-model-for-false-lumen-thrombosis-in-type-b-aortic-dissection-following-thoracic-endovascular-repair
#11
Claudia Menichini, Zhuo Cheng, Richard G J Gibbs, Xiao Yun Xu
Thoracic endovascular repair (TEVAR) has recently been established as the preferred treatment option for complicated type B dissection. This procedure involves covering the primary entry tear to stimulate aortic remodelling and promote false lumen thrombosis thereby restoring true lumen flow. However, complications associated with incomplete false lumen thrombosis, such as aortic dilatation and stent graft induced new entry tears, can arise after TEVAR. This study presents the application and validation of a recently developed mathematical model for patient-specific prediction of thrombus formation and growth under physiologically realistic flow conditions...
November 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29137587/a-lung-model-to-demonstrate-dynamic-gas-trapping-and-intrinsic-positive-end-expiratory-pressure-at-realistic-ventilation-settings
#12
S H Freebairn, R Imlay, E Barrett, Maj Park, R C Freebairn
Intrinsic positive end-expiratory pressure (PEEP) and gas trapping are recognised hazards during ventilation of patients with airflow obstruction. Demonstration of these phenomena on conventional lung models using realistic ventilation settings is difficult. We describe an Intrinsic PEEP Model that is able to demonstrate dynamic gas trapping and intrinsic PEEP at realistic ventilation settings, and demonstrate its ability to develop intrinsic PEEP in a timeframe useful for teaching. The model uses a Heimlich valve to permit a lower resistance on inspiration than expiration...
November 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29137137/a-comparison-of-fpga-and-gpgpu-designs-for-bayesian-occupancy-filters
#13
Luis Medina, Miguel Diez-Ochoa, Raul Correal, Sergio Cuenca-Asensi, Alejandro Serrano, Jorge Godoy, Antonio Martínez-Álvarez, Jorge Villagra
Grid-based perception techniques in the automotive sector based on fusing information from different sensors and their robust perceptions of the environment are proliferating in the industry. However, one of the main drawbacks of these techniques is the traditionally prohibitive, high computing performance that is required for embedded automotive systems. In this work, the capabilities of new computing architectures that embed these algorithms are assessed in a real car. The paper compares two ad hoc optimized designs of the Bayesian Occupancy Filter; one for General Purpose Graphics Processing Unit (GPGPU) and the other for Field-Programmable Gate Array (FPGA)...
November 11, 2017: Sensors
https://www.readbyqxmd.com/read/29136397/psychiatric-inpatient-nurses-perceptions-of-using-motivational-interviewing
#14
Karen M Ragaisis
BACKGROUND: Motivational interviewing (MI) is an evidence-based intervention that may help inpatient psychiatric nurses understand patient beliefs about medication while simultaneously strengthening the therapeutic alliance. OBJECTIVE: Investigate nurses' perceptions regarding use of motivational interviewing after an educational program. DESIGN: A prospective intervention project. RESULTS: Agreement with consistent use of MI skills declined at one month...
November 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29136378/anisotropic-self-assembly-from-isotropic-colloidal-building-blocks
#15
Marcel Rey, Adam D Law, D Martin A Buzza, Nicolas Vogel
Spherical colloidal particles generally self-assemble into hexagonal lattices in two dimensions. However, more com-plex, non-hexagonal phases have been predicted theoretically for isotropic particles with a soft repulsive shoulder but have not been experimentally realized. We study the phase behaviour of microspheres in the presence of poly(N-isopropylacrylamide) (PNiPAm) microgels at the air/water interface. We observe a complex phase diagram, including phases with chain and square arrangements, which exclusively form in the presence of the microgels...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29135999/-life-like-assessment-of-antimicrobial-surfaces-by-a-new-touch-transfer-assay-displays-strong-superiority-of-a-copper-alloy-compared-to-silver-containing-surfaces
#16
Johannes Karl-Mark Knobloch, Sabrina Tofern, Wladimir Kunz, Sara Schütze, Michael Riecke, Werner Solbach, Thomas Wuske
Transmission of bacteria from inanimate surfaces in healthcare associated environments is an important source of hospital acquired infections. A number of commercially available medical devices promise to fulfill antibacterial activity to reduce environmental contamination. In this study we developed a touch transfer assay modeling fingerprint transmission to investigate the antibacterial activity of surfaces, with confirmed antibacterial activity by a modified ISO 22196 (JIS Z 2801) assay to test such surfaces under more realistic conditions...
2017: PloS One
https://www.readbyqxmd.com/read/29135750/student-and-educator-experiences-of-maternal-child-simulation-based-learning-a-systematic-review-of-qualitative-evidence
#17
Karen MacKinnon, Lenora Marcellus, Julie Rivers, Carol Gordon, Maureen Ryan, Diane Butcher
BACKGROUND: Although maternal-child care is a pillar of primary health care, there is a global shortage of maternal-child health care providers. Nurse educators experience difficulties providing undergraduate students with maternal-child learning experiences for a number of reasons. Simulation has the potential to complement learning in clinical and classroom settings. Although systematic reviews of simulation are available, no systematic reviews of qualitative evidence related to maternal-child simulation-based learning (SBL) for undergraduate nursing students and/or educators have been located...
November 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29134674/experimental-validation-of-two-dual-energy-ct-methods-for-proton-therapy-using-heterogeneous-tissue-samples
#18
Esther Bär, Arthur Lalonde, Rongxiao Zhang, Kyung-Wook Jee, Kai Yang, Gregory Sharp, Bob Liu, Gary Royle, Hugo Bouchard, Hsiao-Ming Lu
PURPOSE: The purpose of this work is to evaluate the performance of dual-energy CT (DECT) for determining proton stopping power ratios (SPRs) in an experimental environment and to demonstrate its potential advantages over conventional single-energy CT (SECT) in clinical conditions. METHODS: Water equivalent range (WER) measurements of 12 tissue-equivalent plastic materials and 12 fresh animal tissue samples are performed in a 195 MeV broad proton beam using the dose extinction method...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29134251/meniscal-repair-results-in-inferior-short-term-outcomes-compared-with-meniscal-resection-a-cohort-study-of-6398-patients-with-primary-anterior-cruciate-ligament-reconstruction
#19
Eleonor Svantesson, Riccardo Cristiani, Eric Hamrin Senorski, Magnus Forssblad, Kristian Samuelsson, Anders Stålman
PURPOSE: To compare patient reported outcome measures (PROMs) during the first postoperative year between isolated anterior cruciate ligament (ACL) reconstruction and ACL reconstruction with concomitant meniscal intervention. METHODS: Patients who underwent primary ACL reconstruction at Capio Artro Clinic, Stockholm, Sweden, between 1st Jan 2001 and 31st Dec 2014 without concomitant injuries others than meniscal and/or cartilage lesions were included. Five groups of meniscal treatment simultaneously to ACL reconstruction were established; medial meniscal (MM) resection, MM repair, lateral meniscal (LM) resection, LM repair, and MM + LM resection...
November 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29133330/improving-best-practise-for-patients-receiving-hospital-discharge-letters-a-realist-review-protocol
#20
Katharine Weetman, Geoffrey Wong, Emma Scott, Stephanie Schnurr, Jeremy Dale
INTRODUCTION: Discharge documents are important for transferring information from hospitals to the referring clinician; in the UK and many countries, this is often the patient's general practitioner or family physician. However, patients may or may not receive their discharge letters, and whether patients should routinely receive discharge letters remains unclear. METHODS AND ANALYSIS: The review will consolidate evidence on patients receiving discharge letters through the theory-driven approach of a realist review...
November 12, 2017: BMJ Open
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