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https://www.readbyqxmd.com/read/29051780/sensitivity-of-postnatal-fasting-plasma-glucose-in-identifying-impaired-glucose-tolerance-in-women-with-gestational-diabetes-25-years-data
#1
Habiba Kapaya, Lucy May, Richard Jacques, Priya Madhuvrata
OBJECTIVE: To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance. METHODS: Retrospective study of 1961 women diagnosed with gestational diabetes mellitus. All women were offered oral glucose tolerance test six weeks post-delivery. RESULTS: Of 1961 women, 1090 (56%) returned for postpartum oral glucose tolerance test. A fasting plasma glucose of ≥6...
September 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29051224/advanced-glycation-end-products-impair-nlrp3-inflammasome-mediated-innate-immune-responses-in-macrophages
#2
Seunghwan Son, Inhwa Hwang, Seung Hyeok Han, Jeon-Soo Shin, Ok Sarah Shin, Je-Wook Yu
Advanced glycation end products (AGEs) are adducts formed on proteins by glycation with reducing sugars, such as glucose, and tend to form and accumulate under hyperglycemic conditions. AGE accumulation alters protein function and has been implicated in the pathogenesis of many degenerative diseases such as diabetic complications. AGEs have also been shown to promote the production of pro-inflammatory cytokines, but the roles of AGEs in inflammasome signaling have not been explored in detail. Here, we present evidence that AGEs attenuate activation of the NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs) as determined by caspase-1 processing and interleukin-1β production...
October 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29051099/hyperglycemia-induced-reactive-species-trigger-structural-changes-in-human-serum-albumin-of-type-1-diabetic-subjects
#3
Zarina Arif, Km Neelofar, Mir Yasir Arfat, Asif Zaman, Akhlas Tarannum, Iffat Parveen, Shafeeque Ahmad, Md Adnan Khan, Asim Badar, Shireen Naaz Islam
Chronic oxidative stress fuels pathogenesis of a large set of diseases. Oxidative stress is the cause and consequence of numerous diseases including type 1 diabetes mellitus (T1DM), in which there is selective destruction of insulin producing pancreatic β-cells. Studies have documented that hyperglycemia produces profound stress. In vivo production of numerous reactive oxygen, nitrogen, chlorine species and lipid/sugar oxidation products are result of persistent hyperglycemia. Post-translational modifications by reactive species may create new antigenic epitopes and play a role in the development of autoimmune response...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29050917/sugar-intake-in-sudanese-individuals-was-associated-with-some-features-of-the-metabolic-syndrome-population-based-study
#4
Eman F El-Sayed, Heitham Awadalla, Sufian K Noor, Wadie M Elmadhoun, Amel A Sulaiman, Ahmed O Almobarak, Mohamed H Ahmed
AIM: The aim of this study was to assess the level of sugar intake among Sudanese individuals. MATERIALS AND METHODS: A cross-sectional study with 323 participants. Respondents were grouped by the total intake of added sugars into two groups, one group with sugar intake more than 200 calories per day and other group with sugar intake less than 200 calories per day. Demographic data were collected with anthropometric measurements like body mass index (BMI) and waist circumference...
October 13, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29046327/time-trends-of-dietary-and-lifestyle-factors-and-their-potential-impact-on-diabetes-burden-in-china
#5
Yanping Li, Dong D Wang, Sylvia H Ley, Malik Vasanti, Annie Green Howard, Yuna He, Frank B Hu
OBJECTIVE: To examine the secular trends in risk factors, estimate their impact on type 2 diabetes burden from 1991 to 2011, and project trends in the next 20 years. RESEARCH DESIGN AND METHODS: Risk factor distributions were based on data from the China Health and Nutrition Survey 1991-2011. Diabetes cases attributable to all nonoptimal levels of each risk factor were estimated by applying the comparative risk assessment method. RESULTS: In 2011, high BMI was the leading individual attributable factor for diabetes cases in China responsible for 43...
October 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29046266/guidelines-and-mhealth-to-improve-quality-of-hypertension-and-type-2-diabetes-care-for-vulnerable-populations-in-lebanon-longitudinal-cohort-study
#6
Shannon Doocy, Kenneth E Paik, Emily Lyles, Hok Hei Tam, Zeina Fahed, Eric Winkler, Kaisa Kontunen, Abdalla Mkanna, Gilbert Burnham
BACKGROUND: Given the protracted nature of the crisis in Syria, the large noncommunicable disease (NCD) caseload of Syrian refugees and host Lebanese, and the high costs of providing NCD care, the implications for Lebanon's health system are vast. OBJECTIVE: The aim of this study was to evaluate the effectiveness of treatment guidelines and a mobile health (mHealth) app on quality of care and health outcomes in primary care settings in Lebanon. METHODS: A longitudinal cohort study was implemented from January 2015 to August 2016 to evaluate the effectiveness of treatment guidelines and an mHealth app on quality of care and health outcomes for Syrian and Lebanese patients in Lebanese primary health care (PHC) facilities...
October 18, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29042991/nuclear-factor-%C3%AE%C2%BAb-signaling-negatively-regulates-high-glucose-induced-vascular-endothelial-cell-damage-downstream-of-the-extracellular-signal-regulated-kinase-c-jun-n-terminal-kinase-pathway
#7
Yunzhi Chen, Fang Guo, Zheng Ru, Hongru Kong, Hongwei Sun, Huajun Yu, Wenjun Yang, Qiyu Zhang, Mengtao Zhou
Diabetes mellitus (DM)-induced high blood sugar severely damages vascular endothelial cells (VECs), which are in direct contact with the blood. Diabetic complications cause difficulties in skin wound healing and VECs are important for this process. Previous studies demonstrated that high blood sugar delayed the repair of wounded VECs, but the underlying mechanism has remained elusive. To explore the effects of diabetic conditions on VEC damage, cells were incubated in a medium with high glucose and then subjected to RNA-sequencing based transcriptome analysis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040204/perioperative-glycemic-control-and-postoperative-complications-in-patients-undergoing-emergency-general-surgery-what-is-the-role-of-hba1c
#8
Faisal Jehan, Muhammad Khan, Joseph V Sakran, Mohammad Khreiss, Terence O'Keeffe, Albert Chi, Narong Kulvatunyou, Arpana Jain, El Rasheid Zakaria, Bellal Joseph
BACKGROUND: Plasma Hemoglobin A1c (HbA1c) reflects quality of glucose control in diabetic patients. Literature reports that patients undergoing surgery with an elevated HbA1c level are associated with increased postoperative morbidity and mortality. The aim of our study was to evaluate the impact of HbA1c level on outcomes after emergency general surgery (EGS). METHODS: We performed a 3-year analysis of our prospectively maintained EGS database. Patients who had HbA1c levels measured within 3-months before surgery were included...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29038789/diosgenin-a-novel-aldose-reductase-inhibitor-attenuates-the-galactosemic-cataract-in-rats
#9
Lixia Ji, Lixia Cheng, Zhihong Yang
OBJECTIVE: To seek efficient aldose reductase inhibitors (ARIs) with excellent in vitro and in vivo biological activities against rat galactosemic cataract. METHODS: The method was firstly optimized to screen strong ARIs from nonoriented synthetic compounds and natural extracts. Then, diosgenin was assessed on osmotic expansion of primarily cultured lens epithelial cells (LECs) induced by galactose (50 mM). Diosgenin was administered to galactosemic rats by oral (100 and 200 mg/kg) or direct drinking (0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29036238/-a-phd-completed-periodontitis-diabetes-mellitus-cardiovascular-disease-a-bermuda-triangle
#10
W J Teeuw
The relationship among periodontitis, diabetes mellitus and atherosclerotic cardiovascular disease is complex and can be thought of as a Bermuda triangle. A relationship has been demonstrated between periodontitis, a worsening in the condition of the vascular system and an increased total level of inflammatory markers. Patients with severe periodontitis also show raised levels of glycosylated haemoglobin. This means that severe periodontitis can be an early indication of diabetes mellitus. Periodontal treatment generally promotes improved blood sugar regulation in diabetes patients, an improved condition of the vascular system and a decrease in the total levels of inflammation...
October 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29036213/the-value-of-real-time-continuous-glucose-monitoring-in-premature-infants-of-diabetic-mothers
#11
Hean-Pat Saw, Nai-Wei Yao, Cheng-Di Chiu, Jia-Yuh Chen
To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk of blood sugar abnormalities. Thirty preterm babies (M = 15 and F = 15; ≤ 36 week gestation age) were studied from within 72 hours of delivery. These babies were admitted to the newborn intensive care and were further categorized into groups based on whether their mothers with or without diabetic mellitus. Blood sugar levels were monitored by both RTGMS and the traditional intermittent arterial line (A-Line) glucose method...
2017: PloS One
https://www.readbyqxmd.com/read/29034203/immediate-effect-of-bitter-gourd-ash-gourd-knol-khol-juices-on-blood-sugar-levels-of-patients-with-type-2-diabetes-mellitus-a-pilot-study
#12
G Selvakumar, G Shathirapathiy, R Jainraj, P Yuvaraj Paul
AIM: The aim of this study was to investigate the immediate effect of bitter gourd, Knol-khol, and ash gourd juices on blood glucose level among Type II diabetes mellitus patients. METHODS: In 2015, pilot study was conducted randomly enrolling 30 patients with type 2 diabetes mellitus into three groups in SRK college, India. The first group received bitter gourd juice at FBS range between 120 to 300 mg per dl. The second, third group received Knol-khol, ash gourd juice respectively in the same range of fasting blood sugar level...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29026804/the-effect-of-cardamom-supplementation-on-serum-lipids-glycemic-indices-and-blood-pressure-in-overweight-and-obese-pre-diabetic-women-a-randomized-controlled-trial
#13
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29026408/camel-milk-has-beneficial-effects-on-diabetes-mellitus-a-systematic-review
#14
REVIEW
Parvin Mirmiran, Hanieh-Sadat Ejtahed, Pooneh Angoorani, Fariba Eslami, Fereidoun Azizi
CONTEXT: Controlling diabetes, a worldwide metabolic disease, by effective alternative treatments is currently a topic of great interest. Camel milk is believed to be a suitable hypoglycemic agent in experimental animals and patients with diabetes. The current systematic review aimed at evaluating the effect of camel milk on diabetes. EVIDENCE ACQUISITION: A comprehensive search was dine in PubMed and Scopus for all clinical trials and animal studies documented up to 2015, which focused on the effect of camel milk on diabetes markers...
April 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29022950/diabetes-mellitus-and-the-risk-of-primary-open-angle-glaucoma
#15
P Lavaju, S Shah, S Sharma, R Maskey
BACKGROUND: Diabetes mellitus (DM) is one of the risk factors for Primary open angle glaucoma (POAG). Inclusion of DM as a risk factor for POAG is controversial. The objectives of the study were to investigate whether Type II (T2) DM is a risk factor for POAG and to determine central corneal thickness (CCT) in the subjects with T2DM and to examine the relationship between T2DM and intraocular pressure (IOP). MATERIALS AND METHODS: A comparative cross sectional study was conducted including 189 subjects of age > 40 years...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29021975/effect-of-melatonin-versus-vitamin-d-as-antioxidant-and-hepatoprotective-agents-in-stz-induced-diabetic-rats
#16
Abdulmonim A Alqasim, Essam Eldin M Noureldin, Sami H Hammadi, Ghada E Esheba
BACKGROUND: Diabetes mellitus (DM) is a serious chronic disease, with multiple complications including hepatopathy associated with imbalance of the oxidative status. The purpose of this study is to observe possible protective effects of vitamin-D and melatonin on glucose profile, antioxidant-oxidant status, lipid peroxidation, and histopathological protection of the liver in streptozotocin-induced diabetic rats. METHODS: Eighty three male albino rats were divided into nine groups as follows: G1 (n = 10) Normal control rats; G2 (n = 8) were normal rats treated with melatonin only; G3 (n = 10) were normal rats treated with vitamin D only; G4 (n = 9) were diabetic rats, which received no medications; G5 (n = 8) were diabetic rat treated with insulin only; G6 (n = 10) were diabetic rats treated with melatonin only; G7 (n = 9) were diabetic rats treated with melatonin and insulin; G8 (n = 9) were diabetic rats treated with vitamin D only; G9 (n = 10) were diabetic rats treated with vitamin D and insulin...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29021891/a-good-sugar-d-mannose-suppresses-autoimmune-diabetes
#17
Yun-Bo Shi, Deling Yin
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27-29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29021286/pomegranate-juice-but-not-an-extract-confers-a-lower-glycemic-response-on-a-high-glycemic-index-food-randomized-crossover-controlled-trials-in-healthy-subjects
#18
Asimina Kerimi, Hilda Nyambe-Silavwe, Julia S Gauer, Francisco A Tomás-Barberán, Gary Williamson
Background: Low-glycemic index diets have demonstrated health benefits associated with a reduced risk of developing type 2 diabetes.Objectives: We tested whether pomegranate polyphenols could lower the glycemic response of a high-glycemic index food when consumed together and the mechanism by which this might occur.Design: We compared the acute effect of a pomegranate juice and a polyphenol-rich extract from pomegranate (supplement) on the bread-derived postprandial blood glucose concentration in 2 randomized, crossover, controlled studies (double-blinded for the supplements), each on 16 healthy volunteers...
October 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29020428/improvement-of-recalcitrant-diabetic-macular-edema-after-peritoneal-dialysis
#19
Sally S Ong, Akshay S Thomas, Sharon Fekrat
Nephropathy may be an independent and contributory risk factor for diabetic macular edema (DME). A 69-year-old man who had previously been treated with panretinal laser photocoagulation for proliferative diabetic retinopathy as well as with steroid and anti-vascular endothelial growth factor injections for DME declined additional treatment for the DME, which was worse in the right eye. The DME was observed without further treatment for the next 36 months. Despite well-controlled blood sugar, blood pressure, and lipid levels, the DME remained unchanged...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28988760/the-effects-of-overnight-nutrient-intake-on-hypothalamic-inflammation-in-a-free-choice-diet-induced-obesity-rat-model
#20
Evita Belegri, Leslie Eggels, Unga A Unmehopa, Joram D Mul, Anita Boelen, Susanne E la Fleur
Consumption of fat and sugar induces hyperphagia and increases the prevalence of obesity and diabetes type 2. Low-grade inflammation in the hypothalamus, a key brain area involved in the regulation of energy homeostasis is shown to blunt signals of satiety after long term high fat diet. The fact that this mechanism can be activated after a few days of hyperphagia before apparent obesity is present led to our hypothesis that hypothalamic inflammation is induced with fat and sugar consumption. Here, we used a free-choice high-fat high-sugar (fcHFHS) diet-induced obesity model and tested the effects of differential overnight nutrient intake during the final experimental night on markers of hypothalamic inflammation...
October 5, 2017: Appetite
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