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https://www.readbyqxmd.com/read/29231845/maillard-proteomics-opening-new-pages
#1
REVIEW
Alena Soboleva, Rico Schmidt, Maria Vikhnina, Tatiana Grishina, Andrej Frolov
Protein glycation is a ubiquitous non-enzymatic post-translational modification, formed by reaction of protein amino and guanidino groups with carbonyl compounds, presumably reducing sugars and α-dicarbonyls. Resulting advanced glycation end products (AGEs) represent a highly heterogeneous group of compounds, deleterious in mammals due to their pro-inflammatory effect, and impact in pathogenesis of diabetes mellitus, Alzheimer's disease and ageing. The body of information on the mechanisms and pathways of AGE formation, acquired during the last decades, clearly indicates a certain site-specificity of glycation...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29229363/comparison-of-the-effects-of-flaxseed-oil-and-sunflower-seed-oil-consumption-on-serum-glucose-lipid-profile-blood-pressure-and-lipid-peroxidation-in-patients-with-metabolic-syndrome
#2
Atefeh Akrami, Farzad Nikaein, Siavash Babajafari, Shiva Faghih, Hassan Yarmohammadi
BACKGROUND: Metabolic syndrome (MetSyn) increases the risk of type II diabetes and morbidity and mortality due to cardiovascular diseases. Flaxseed oil (FO), as a functional food, is one of the major vegetal sources of essential omega-3 fatty acids. OBJECTIVE: This study aimed to compare the effects of consumption of FO and sunflower seed oil (SO) on lipid peroxidation and other symptoms of MetSyn. METHODS: This randomized controlled interventional trial was conducted on 60 volunteers aged 30 to 60 years who were diagnosed with MetSyn in Shiraz, Iran...
November 20, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29229075/does-periodontal-inflammation-affect-glycosylated-haemoglobin-level-in-otherwise-systemically-healthy-individuals-a-hospital-based-study
#3
Rosamma Joseph Vadakkekuttical, Priyanka Chand Kaushik, Jerry Mammen, Joseraj Manaloor George
BACKGROUND AND OBJECTIVES: Microbial biofilm and host susceptibility play an important role in the initiation and progression of periodontitis. Periodontitis is considered the sixth complication of diabetes mellitus and a bidirectional relationship exists between diabetes and periodontitis. This cross-sectional observational study was undertaken to evaluate the glycosylated haemoglobin (HbA1c) level in chronic periodontitis. METHODS: The study involved 100 subjects...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29228854/the-design-and-development-of-myt1dhero-a-mobile-app-for-adolescents-with-type-1-diabetes-and-their-parents
#4
Bree E Holtz, Katharine M Murray, Denise D Hershey, Joshua Richman, Julie K Dunneback, Arpita Vyas, Michael A Wood
Introduction Type 1 diabetes impacts approximately 1.25 m Americans, many of them young children. As a child grows, there is a transition towards independence and they must learn to manage their diabetes independently. The objective of this study was to design, develop and conduct a prototype test to assess the satisfaction and feasibility of a mobile app for adolescents with type 1 diabetes and their parents to aid in this transition. Methods Ten parent/adolescent groups used MyT1DHero for four weeks. They were given a pre-test/post-test survey regarding family conflict with three tasks of diabetes management and the general tone of family communication...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29226729/formulation-of-sitagliptin-loaded-oral-polymeric-nano-scaffold-process-parameters-evaluation-and-enhanced-anti-diabetic-performance
#5
Mohammed Asadullah Jahangir, Ruqaiyah Khan, Syed Sarim Imam
PURPOSE: The aim of the study to formulate and statistically optimize sitagliptin-loaded eudragit nanoparticles (SIT-NPs) and evaluate the in-vitro pharmaceutical quality and in-vivo anti-diabetic assessment. METHOD: SIT-NPs were prepared by using combination method of solvent evaporation and nano-precipitation techniques. The influence of different independent variables as eudragit RL100 concentration (%), tween 80 concentration (%) and sonication time (min) were evaluated on dependent variables like particle size (nm), drug loading (%) and in-vitro drug release (%)...
December 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29226480/successful-pancreas-transplantation-alone-is-associated-with-excellent-self-identified-health-score-and-glucose-control-a-retrospective-study-from-a-high-volume-center-in-the-united-states
#6
Joseph R Scalea, Lauren Pettinato, Blythe Fiscella, Amanda Bartosic, Allison Piedmonte, Jastine Paran, Niket Todi, Eric J Siskind, Stephen T Bartlett
BACKGROUND: The benefits of pancreas transplantation are often difficult to measure. Here, we sought to determine the difference in quality of life for diabetic patients with and without a functional pancreas transplant alone (PTA). METHODS: PTA cases from 1993-2015 were considered. An IRB-approved survey inclusive of 15 questions spanning 4 domains was employed. Chi-square, Fischer's exact, and the T-test were used where appropriate. RESULTS: 137 PTAs were performed during the study period...
December 11, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29225896/incidence-of-diabetes-mellitus-and-factors-associated-with-its-development-in-hiv-positive-patients-over-the-age-of-50
#7
Faizal Samad, Marianne Harris, Cathy M Puskas, Monica Ye, Jason Chia, Sarah Chacko, Gregory P Bondy, Viviane D Lima, Julio Sg Montaner, Silvia A Guillemi
Objective: We sought to determine the incidence and factors associated with development of diabetes mellitus (DM) in older HIV-infected individuals. Research design and methods: We analyzed data from people living with HIV (PLWH) ≥50 years of age enrolled in a large urban HIV outpatient clinic in Vancouver, British Columbia. Patients were categorized as having DM if they had random blood sugar ≥11.1 mmol/L, fasting blood sugar ≥7 mmol/L, HbA1C ≥6.5%, antidiabetic medication use during the follow-up period, or medical chart review confirming diagnosis of DM...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29224633/over-the-counter-medicines-and-diabetes-care
#8
Jeff Taylor
OBJECTIVES: People with diabetes turn to over-the-counter (OTC) medicines for many ailments. The focus of this brief review is the impact common OTC medicines might have on this group of patients. METHODS: Three types of OTC medicines were selected as most deserving of attention: 3 herbal agents, nonsteroidal anti-inflammatory drugs (NSAIDs) and cough/cold products. Existing literature was used to determine precautions that might be in order. RESULTS: Herbal/natural agents with the potential to impact blood sugar have been identified in various reports...
December 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29221543/community-health-workers-in-diabetes-prevention-and-management-in-developing-countries
#9
REVIEW
Halimatou Alaofè, Ibitola Asaolu, Jennifer Ehiri, Hayley Moretz, Chisom Asuzu, Mobolanle Balogun, Olayinka Abosede, John Ehiri
BACKGROUND: There is limited evidence regarding the effect of community health worker (CHW) interventions for prevention and management of the burgeoning epidemic of noncommunicable diseases (NCDs) in low- and middle-income countries (LMICs). The objective of this review was to critically appraise evidence regarding the effectiveness of CHW interventions for prevention and management of type 2 diabetes mellitus (T2DM) in LMICs. METHODS: To identify studies that reported the effect of CHW interventions for prevention and management of T2DM in LMICs, Medline/PubMed, EMBASE, Web of Science (Science and Social Science Citation Indices), EBSCO (PsycINFO and CINAHL), POPLINE, the Cochrane Metabolic and Endocrine Disorders Group's Specialized Register, the Cochrane Central Register of Controlled Trials, the Grey literature (Google, Google Scholar), and reference lists of identified articles were searched from inception to May 31, 2017...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29219130/effects-of-health-education-tool-on-select-epidemiological-factors-associated-with-adult-obese-urban-slum-women
#10
Deepika Pradeep Vora, Pallavi S Shelke
BACKGROUND: National Family Health Survey-3 (2005-2006) India, found that 14.8% of Ever-Married Adults (age 15-49 years) had Body Mass Index (BMI) in the ranges of overweight and obese; compared to 10.6% in the National Family Health Survey-2. These figures highlighted the fact that India already faces a dual burden of chronic malnutrition, i.e., obesity, besides undernutrition. Higher BMI, especially, increased abdominal fat is an important determinant of the development of diabetes...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29218127/the-effect-of-group-discussion-based-education-on-self-management-of-adults-with-type-2-diabetes-mellitus-compared-with-usual-care-a-randomized-control-trial
#11
Hosein Habibzadeh, Akbar Sofiani, Leyla Alilu, Mark Gillespie
Objectives: We sought to determine the effect of group discussion-based education on the self-management capability of patients with type 2 diabetes in Iran. Methods: This randomized control trial was conducted on 90 patients with type 2 diabetes. Participants were allocated randomly into one of two groups; intervention and control. The intervention group received the group discussion-based education while the control group received routine care only. The Lin's self-management questionnaire was completed at baseline and three months post-intervention...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29218064/non-diabetic-hyperglycemia-and-some-of-its-correlates-in-icu-hospitalized-patients-receiving-enteral-nutrition
#12
Mohammad Amin Valizadeh Hasanloei, Zahra Vahdat Shariatpanahi, Davoud Vahabzadeh, Zakaria Vahabzadeh, Leila Nasiri, Ali Shargh
Introduction: Hyperglycemia is a common occurrence in critically ill patients, and its prevalence in patients receiving nutritional support is much higher than in other patients. The non-diabetic form is associated with more undesirable outcomes. This study was performed to determine the prevalence of non-diabetic hyperglycemia and its correlates in patients receiving enteral nutrition. Material and Methods: This cross-sectional study was performed between March and December 2015...
September 2017: Mædica
https://www.readbyqxmd.com/read/29217920/correlation-between-serum-lipid-profile-with-anthropometric-and-clinical-variables-in-patients-with-type-2-diabetes-mellitus
#13
Belete Biadgo, Solomon Mekonnen Abebe, Habtamu Wondifraw Baynes, Mohammed Yesuf, Aynadis Alemu, Molla Abebe
Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There is ample evidence that abnormalities in lipid metabolism are important risk factors for increased incidence of diabetes associated complications. The most important risk indicators for these complications are lipid profile abnormalities. Therefore, the aim of this study was to assess the correlation between serum lipid profile with anthropometric and clinical variables among type 2 diabetes mellitus patients...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29215581/stress-induced-hyperglycemia-in-diabetes-a-cross-sectional-analysis-to-explore-the-definition-based-on-the-trauma-registry-data
#14
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: The diagnosis of diabetic hyperglycemia (DH) does not preclude a diabetes patient from having a stress-induced hyperglycemic response. This study aimed to define the optimal level of elevated glucose concentration for determining the occurrence of stress-induced hyperglycemia (SIH) in patients with diabetes. Methods: This retrospective study reviewed the data of all hospitalized trauma patients, in a Level I trauma center, from 1 January 2009 to 31 December 2016. Only adult patients aged ≥20 years, with available data on serum glucose and glycated hemoglobin A1c (HbA1c) levels upon admission, were included in the study...
December 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29211705/a-workshop-on-dietary-sweetness-is-it-an-issue
#15
A Wittekind, K Higgins, L McGale, C Schwartz, N S Stamataki, G K Beauchamp, A Bonnema, P Dussort, S Gibson, C de Graaf, J C G Halford, C F M Marsaux, R D Mattes, J McLaughlin, D J Mela, S Nicklaus, P J Rogers, I A Macdonald
This report summarises a workshop convened by ILSI Europe on 3rd and 4th April 2017 to discuss the issue of dietary sweetness. The objectives were to understand the roles of sweetness in the diet; establish whether exposure to sweetness affects diet quality and energy intake; and consider whether sweetness per se affects health. Although there may be evidence for tracking of intake of some sweet components of the diet through childhood, evidence for tracking of whole diet sweetness, or through other stages of maturity are lacking...
December 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29210642/antidiabetics-structural-diversity-of-molecules-with-a-common-aim
#16
Jelena B Popovic-Dordevic, Ivana I Jevtic, Tatjana P Stanojkovic
BACKGROUND: Diabetes mellitus type 2 (DMT2) is an endocrine disease of global proportions which is currently affecting 1 in 12 adults in the world, with still increasing prevalence. World Health Organization (WHO) declared this worldwide health problem, as an epidemic disease, to be the only non-infectious disease with such categorization. People with DMT2 are at increased risk of various complications and have shorter life expectancy. The main classes of oral antidiabetic drugs accessible today for DMT2 vary in their chemical composition, modes of action, safety profiles and tolerability...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29207741/prevalence-of-chronic-morbidity-and-sociodemographic-profile-of-police-personnel-a-study-from-gujarat
#17
Kishankumar Maheshkumar Bhatia, Niraj Pandit
Introduction: The police personnel are special group of population that work for minimum 12 hours a day. They are at risk of various types of chronic morbidities. Aim: To determine the sociodemographic, chronic morbidity and health profile of police personnel of Vadodara district. Materials and Methods: It was a cross-sectional study conducted on the police force of Vadodara district, Gujarat, India. The present study was the outcome of health checkup camp for police personnel...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207492/rapid-non-enzymatic-glycation-of-the-insulin-receptor-under-hyperglycemic-conditions-inhibits-insulin-binding-in-vitro-implications-for-insulin-resistance
#18
Tyler Rhinesmith, Thomas Turkette, Robert Root-Bernstein
The causes of insulin resistance are not well-understood in either type 1 or type 2 diabetes. Insulin (INS) is known to undergo rapid non-enzymatic covalent conjugation to glucose or other sugars (glycation). Because the insulin receptor (IR) has INS-like regions associated with both glucose and INS binding, we hypothesize that hyperglycemic conditions may rapidly glycate the IR, chronically interfering with INS binding. IR peptides were synthesized spanning IR- associated INS-binding regions. Glycation rates of peptides under hyperglycemic conditions were followed over six days using matrix assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry...
December 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29205704/hypoglycemia-in-sulfonylurea-treated-kcnj11-neonatal-diabetes-mild-moderate-symptomatic-episodes-occur-infrequently-but-none-involving-unconsciousness-or-seizures
#19
Monica S Lanning, David Carmody, Łukasz Szczerbiński, Lisa R Letourneau, Rochelle N Naylor, Siri Atma W Greeley
BACKGROUND: Neonatal diabetes mellitus (NDM) caused by mutations in KCNJ11 can be successfully treated with high dose oral sulfonylureas; however, little data is available on the risk of hypoglycemia. OBJECTIVE: To determine the frequency, severity, and clinical significance of hypoglycemia in KCNJ11-related NDM. METHODS: Utilizing the University of Chicago Monogenic Diabetes Registry, parents completed an online questionnaire addressing hypoglycemia...
December 5, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29203097/euclea-undulata-thunb-review-of-its-botany-ethnomedicinal-uses-phytochemistry-and-biological-activities
#20
REVIEW
Alfred Maroyi
Euclea undulata (E. undulata) is traditionally used for the treatment of body pains, chest complaints, cough, diabetes, diarrhoea, headaches, heart diseases and toothaches in southern Africa. This study was aimed at reviewing the botany, ethnopharmacology and biological activities of E. undulata in southern Africa. Results presented in this study are based on review of literature using search engines such as Science Direct, Springerlink, Scopus, PubMed, Web of Science, BioMed Central and Google Scholar. Herbal medicine is prepared from the decoctions of the roots, bark and leaves, and extracts of these plant parts have demonstrated anticholinesterase, anti-inflammatory, antimicrobial, antimycobacterial, antiplasmodial, antioxidant and hypoglycaemic activities...
November 2017: Asian Pacific Journal of Tropical Medicine
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