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https://www.readbyqxmd.com/read/28346398/sirtuin-1-sirt1-overexpression-in-baf3-cells-contributes-to-cell-proliferation-promotion-apoptosis-resistance-and-pro-inflammatory-cytokine-production
#1
Qian Wang, Chao Yan, Miaomiao Xin, Li Han, Yunqing Zhang, Mingshu Sun
BACKGROUND B lymphocyte hyperactivity is a main characteristic of systemic lupus erythematosus (SLE), and B lymphocytes play a prominent pathogenic role in the development and progression of SLE. The aim of this study was to investigate the role of Sirtuin 1 (Sirt1) in B lymphocytes. MATERIAL AND METHODS Mouse B lymphocytes BaF3 was transfected with Sirt1 vector or shRNA against Sirt1. Then the transfected cells viability and apoptosis were respectively determined by MTT assay and flow cytometry. In addition, the mRNA levels of three pro-inflammatory cytokines and p53 were detected by RT-PCR...
March 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28345840/correlation-between-epstein-barr-virus-infection-and-disease-activity-of-systemic-lupus-erythematosus-a-cross-sectional-study
#2
Ahmad Piroozmand, Hamed Haddad Kashani, Batool Zamani
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease for whose pathogenesis viral infections are important. The Epstein-Barr virus (EBV) is the main infectious etiological agent. This study aimed to quantitative evaluation of EBV in SLE patients. Materials and Methods: In this cross-sectional study, 40 patients with SLE diagnosed based on American College of Rheumatology criteria were selected using purposive sampling. All were included in the study after obtaining informed consent for participation...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345423/systemic-lupus-erythematosus-and-hearing-disorders-literature-review-and-meta-analysis-of-clinical-and-temporal-bone-findings
#3
Arianna Di Stadio, Massimo Ralli
Objective This literature review and meta-analysis was performed to evaluate the correlations among hearing and vestibular clinical symptoms, temporal bone findings, and pathological mechanisms in patients with systemic lupus erythematosus (SLE). Study design Relevant papers in the literature were retrospectively reviewed. Clinical hearing aspects in patients with SLE and relevant temporal bone studies in the same field were analyzed. Methods PubMed and Google Scholar searches were performed using the following keywords: "auto-immune disease," "systemic lupus erythematosus (SLE)," "hearing loss," "temporal bone study," "vertigo," "dizziness," "tinnitus," "ear symptoms," "treatment," "diagnosis," "symptoms," "etiopathogenesis," "Wegener granulomatosis," "Sjogren," "polyarteritis nodosa," "Cogan syndrome," and "granulomatosis...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28344669/belimumab-in-systemic-lupus-erythematosus-sle-evidence-to-date-and-clinical-usefulness
#4
REVIEW
Sara Guerreiro Castro, David A Isenberg
Systemic lupus erythematosus (SLE) is a complex autoimmune rheumatic disease with multiple presentations, whose management presents many challenges. Many disease modifying or immunosuppressive drugs have been used with limited success, especially in patients with more severe disease activity. Belimumab is the first drug to be approved specifically for the treatment of SLE in more than 50 years. By blocking the B-cell activating factor, it interferes in B-cell differentiation and survival. Here we consider the results of the clinical trials that led to its approval, as well as the post-hoc analyses, follow-up studies and the current trials...
March 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28343620/vascular-endothelial-growth-factor-g1612a-rs10434-gene-polymorphism-and-neuropsychiatric-manifestations-in-systemic-lupus-erythematosus-patients
#5
Sherif Taha, Sherif Mohammed Gamal, Mohamed Nabil, Nahla Naeem, Dalia Labib, Ibrahim Siam, Tamer Atef Gheita
AIM: To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. PATIENTS AND METHODS: Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without...
March 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28342978/a-new-benzenediamine-derivative-modulates-toll-like-receptors-induced-myeloid-dendritic-cells-activation-and-ameliorates-lupus-like-syndrome-in-mrllpr-lpr-mice
#6
Sheng Gao, Yongsheng Gong, Jianjian Ji, Linbo Yuan, Liping Han, Yimin Guo, Xiaofang Fan, Yayi Hou, Chunyan Hua
Modulators of the over-activation of myeloid dendritic cells (mDCs) by Toll-like receptors (TLRs) have an advantage in the treatment of systemic lupus erythematosus (SLE). This study was designed to evaluate the effects of FC-99, a novel benzenediamine derivative, on TLR-induced activation of mDCs, and to assess the efficacy of FC-99 in a murine model of SLE. In vitro, FC-99 inhibited the phenotypic (CD40 and MHC-II) and functional activation (IL-12 and CXCL10) of mDCs induced by TLR ligands. In vivo, MRLlpr/lpr mice displayed renal diseases associated with increased levels of proteinuria and immunoglobulin, which were ameliorated by FC-99...
March 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28340077/idiopathic-non-lupus-full-house-nephropathy-is-associated-with-poor-renal-outcome
#7
Emilie C Rijnink, Y K Onno Teng, Tineke Kraaij, Ron Wolterbeek, Jan A Bruijn, Ingeborg M Bajema
Background.: Full-house immunofluorescence in combination with various histopathologic lesions in the renal biopsies of patients without overt systemic lupus erythematosus (SLE) poses a diagnostic challenge. In this setting, the biopsy findings are sometimes termed non-lupus 'full-house nephropathy' (FHN). It is presently unknown whether idiopathic non-lupus FHN is clinicopathologically and prognostically distinct from lupus FHN. Methods.: We included non-lupus FHN patients and lupus FHN controls (four or more American College of Rheumatology or Systemic Lupus International Collaborating Clinics criteria) who were biopsied between 1968 and 2014 at the Leiden University Medical Centre...
March 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339952/value-of-multidisciplinary-reassessment-in-attribution-of-neuropsychiatric-events-to-systemic-lupus-erythematosus-prospective-data-from-the-leiden-npsle-cohort
#8
César Magro-Checa, Els J Zirkzee, Liesbeth J J Beaart-van de Voorde, Huub A Middelkoop, Nic J van der Wee, Menno V Huisman, Jeroen Eikenboom, Nyika D Kruyt, Mark A van Buchem, Tom W J Huizinga, Gerda M Steup-Beekman
Objective.: To determine the contribution of reassessment in the attribution process of neuropsychiatric (NP) events to SLE or other aetiologies in a large, prospective and multidisciplinary assessed NPSLE cohort and to compare these results with other available attribution models for NP events occurring in SLE. Methods.: Three hundred and four consecutive SLE patients presenting NP events were evaluated. All subjects underwent standardized multidisciplinary medical, neuropsychological, laboratory and radiological examination on the inclusion and reassessment dates...
February 28, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339802/alterations-in-urinary-collagen-peptides-in-lupus-nephritis-subjects-correlate-with-renal-dysfunction-and-renal-histopathology
#9
Ru Wei, Benbo Gao, Fei Shih, Ann Ranger, Andrea Dearth, Harald Mischak, Justyna Siwy, Nicolas Wisniacki, Michelle Petri, Linda C Burkly
Background.: The excessive accumulation of extracellular matrix (ECM) in the renal tubulointerstitium is a key component of chronic renal damage in lupus nephritis (LN) and a critical determinant of the disease progression to renal failure. Detection of fibrosis requires renal biopsy and is therefore limited by high risks associated with an invasive procedure. This study explores whether a unique LN urinary peptidome can be identified and whether LN-specific alteration reflects the underlying fibrogenic process of altered ECM turnover...
February 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339674/family-history-of-systemic-lupus-erythematosus-and-risk-of-autoimmune-disease-nationwide-cohort-study-in-denmark-1977-2013
#10
Constance Jensina Ulff-Møller, Jacob Simonsen, Kirsten Ohm Kyvik, Søren Jacobsen, Morten Frisch
Objective.: To provide population-based estimates of relative risk of SLE and other autoimmune diseases (ADs) in relatives of SLE patients. Methods.: A cohort of 5 237 319 Danish residents identified through the Civil Registration System was coupled to their relatives through the parental link and followed for SLE and other ADs between 1977 and 2013 through linkage to the National Patient Register. Twin zygosity was established through the Danish Twin Registry. Hazard ratios (HRs) with 95% CIs were calculated using Cox proportional hazards regression analyses...
February 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339495/microrna-expression-profiles-identify-disease-specific-alterations-in-systemic-lupus-erythematosus-and-primary-sj%C3%A3-gren-s-syndrome
#11
Ji-Qing Chen, Gábor Papp, Szilárd Póliska, Krisztina Szabó, Tünde Tarr, Bálint László Bálint, Péter Szodoray, Margit Zeher
The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28339366/jaccoud-s-arthropathy-in-systemic-lupus-erythematosus-clinical-laboratory-and-ultrasonographic-features
#12
Fulvia Ceccarelli, Laura Massaro, Carlo Perricone, Monica Pendolino, Enrica Cipriano, Simona Truglia, Francesca Miranda, Francesca Romana Spinelli, Cristiano Alessandri, Guido Valesini, Fabrizio Conti
OBJECTIVES: Jaccoud's arthropathy (JA) is a deforming, non-erosive arthritis, occurring in 2-35% of systemic lupus erythematosus (SLE) patients. We aimed to evaluate JA patients in a wide monocentric SLE cohort in terms of clinical, serological and ultrasonographic features. METHODS: Consecutive SLE patients (ACR criteria 1997) were evaluated. The JA index was applied for patients with reducible deformities. Patients with a JA index ≥5 underwent physical examination, blood testing and ultrasound (US) assessment...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339361/anti-n-methyl-d-aspartate-receptor-antibodies-are-associated-with-fibromyalgia-in-patients-with-systemic-lupus-erythematosus-a-case-control-study
#13
Dong-Jin Park, Yukitoshi Takahashi, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Jung-Kil Lee, Shin-Seok Lee
OBJECTIVES: The high concordance between systemic lupus erythematosus (SLE) and fibromyalgia (FM) suggests common underlying mechanisms related to pain and distress in both patient groups. Increasing evidence indicates that N-methyl-D-aspartate receptors (NMDARs) play a major role in the induction and maintenance of central sensitisation with chronic pain. In this study, we evaluated the role of anti-NMDAR antibodies in the development of FM in patients with SLE. METHODS: Sera from 104 patients with SLE, 112 patients with FM, and 110 healthy controls were analysed to detect antibodies to the N-terminus of the 2B subunit of NMDARs (GluN2B)...
March 10, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28338767/decreased-cd1d-level-is-associated-with-cd86-over-expression-in-b-cells-from-systemic-lupus-erythematosus
#14
Fei Liu, Jianjian Ji, Xiujun Li, Xiaojing Li, Jingjing Xu, Huimin Yue, Shuli Zhao, Hongye Fan, Yayi Hou
The disorder of B cells is one of the hallmarks of systemic lupus erythematosus (SLE). The activation state indicated by CD86 of B cells from SLE is well known, while the defect of regulatory B cells mediated by CD1d is also responsible for the process of SLE. In the present study, we focused on the relationship between B cell activation mediated by CD86 and B cell regulatory function mediated by CD1d. Our results showed that the level of CD1d in B cells was decreased during the early stages of B6.MRLlpr SLE mice and imiquimod-treated (IMQ-treated) mice, while the level of CD86 was significantly increased at the late stage...
March 3, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28338190/the-role-of-mir-146a-in-modulating-traf6-induced-inflammation-during-lupus-nephritis
#15
C-Z Zheng, Y-B Shu, Y-L Luo, J Luo
OBJECTIVE: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). A previous study showed decreased expression level of microRNA (miR)-146a in LN patients, indicating its possible role in LN pathogenesis. PATIENTS AND METHODS: A total of 98 LN patients were recruited, for the collection of renal tissue samples during biopsy or surgery. Another cohort of 15 patients who had renal tumor resection was recruited as the control group, for the further comparison of expression levels of miR-146a, TRAF6 and p-p65 in tissues...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28336124/ultraviolet-b-inhibition-of-dnmt1-activity-via-ahr-activation-dependent-sirt1-suppression-in-cd4-t-cells-from-systemic-lupus-erythematosus-patients
#16
Zhouwei Wu, Xingyu Mei, Zuolin Ying, Yue Sun, Jun Song, Weimin Shi
BACKGROUND: Previous studies have reported that ultraviolet B (UVB) inhibits DNA methyltransferase1 (DNMT1) activity in CD4+ T cells from systemic lupus erythematosus (SLE) patients. Silent mating type information regulation 2 homolog 1 (SIRT1) is a type of Class III histone deacetylases (HDACs), and has been reported to play roles in the pathogenesis of different autoimmune diseases and can modulate DNMT1 activity. Moreover, aryl hydrocarbon receptor (AhR) has been reported to link UVB with SLE...
March 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28331377/management-of-systemic-lupus-erythematosus-during-pregnancy-challenges-and-solutions
#17
REVIEW
Caroline L Knight, Catherine Nelson-Piercy
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal-neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28331294/spotlight-on-blisibimod-and-its-potential-in-the-treatment-of-systemic-lupus-erythematosus-evidence-to-date
#18
REVIEW
Aleksander Lenert, Timothy B Niewold, Petar Lenert
B cells in general and BAFF (B cell activating factor of the tumor necrosis factor [TNF] family) in particular have been primary targets of recent clinical trials in systemic lupus erythematosus (SLE). In 2011, belimumab, a monoclonal antibody against BAFF, became the first biologic agent approved for the treatment of SLE. Follow-up studies have shown excellent long-term safety and tolerability of belimumab. In this review, we critically analyze blisibimod, a novel BAFF-neutralizing agent. In contrast to belimumab that only blocks soluble BAFF trimer but not soluble 60-mer or membrane BAFF, blisibimod blocks with high affinity all three forms of BAFF...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28331209/systemic-lupus-erythematosus-defective-cd11b-raises-ifn-levels-in-sle
#19
Joanna Collison
No abstract text is available yet for this article.
March 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28329638/developing-a-continuous-quality-improvement-assessment-using-a-patient-centered-approach-in-optimizing-sle-disease-control
#20
Katelyn Updyke, Brittany Urso, James A Solomon
Systemic lupus erythematous is a multi-organ autoimmune disease in which the patient has "lost" self- tolerance and developed immune-complexes containing self-antigen that cause disease through tissue inflammation and multi-organ damage. Patients often have unpredictable flares in symptoms with poorly identified triggers. However, it has been suggested in other literature that exogenous exposures, including ingested beef, cigarette smoke, UV radiation, metal-complexing agents, and infections can contribute to exacerbations and improvements in SLE symptoms...
September 15, 2016: Dermatology Online Journal
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