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Brain Benign Tumors

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https://www.readbyqxmd.com/read/29138018/anti-tumor-effects-of-cold-atmospheric-pressure-plasma-on-vestibular-schwannoma-demonstrate-its-feasibility-as-an-intra-operative-adjuvant-treatment
#1
Yeo Jun Yoon, Michelle J Suh, Hyun Young Lee, Hae June Lee, Eun Ha Choi, In Seok Moon, Kiwon Song
Vestibular schwannoma (VS), although a benign intracranial tumor, causes morbidities by brainstem compression. Since chemotherapy is not very effective in most Nf2-negative schwannomas, surgical removal or radiation therapy is required. However, depending on the size and site of the tumor, these approaches may cause loss of auditory or vestibular functions, and severely decrease the post-surgical wellbeing. Here, we examined the feasibility of cold atmospheric pressure plasma (CAP) as an intra-operative adjuvant treatment for VS after surgery...
November 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29109062/dural-penetration-of-cavernous-hemangioma-on-skull-an-uncommon-clinical-presentation
#2
Hyun-Seung Ryu, Kyung-Sub Moon, Kyung-Hwa Lee, In-Young Kim, Shin Jung
Cavernous hemangioma (CH) of bone is a rare, benign neoplasm and usually found in the vertebral body. This tumor rarely develops in the calvaria, with predilection to occur in the frontal and temporo-parietal bones. A 56-year-old man with a right frontal palpable mass was admitted to our hospital. Magnetic resonance imaging (MRI) revealed a large extra-axial tumor in right frontal bone. Intraoperatively, the bony mass involved the multilayers composed of extracranium-skull-dura-intradura-cortex. Pathological examination revealed a typical calvarial CH penetrating dura mater...
November 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29098570/intracranial-melanotic-schwannomas-a-rare-variant-with-unusual-adherent-features
#3
D Mahato, T Vivas-Buitrago, K Gassie, M Jentoft, D Tavanaiepour, A Quiñones-Hinojosa
Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-points to be considered when diagnosing and treating patients with this rare known entity. This is the case of a 43 years-old woman who presented with severe headaches 9 years ago (2008). At that time, MRI of the brain showed a 1...
November 2, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29062689/occipital-dysembryoplastic-neuroepithelial-tumor-presenting-as-adult-onset-temporal-epilepsy
#4
Riddhi Patira, Cody Nathan, Sarah Zubkov, Camilo Gutierrez, Charles Munyon, Abir Mukherjee, Mercedes Jacobson
Dysembryoplastic neuroepithelial tumor (DNET) is a benign brain tumor which commonly presents as childhood-onset temporal lobe epilepsy (TLE). We present a case of histologically proven DNET with a clinical presentation and scalp EEG suggestive of adult-onset TLE. MRI showed an occipital lesion. PET showed abnormal metabolism of the occipital lesion and the ipsilateral temporal lobe; raising concern for an abnormal functional network reorganization. Intracranial EEG showed interictal spikes and seizures originating from the occipital lesion with no seizures emanating from the temporal lobe...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29039591/dabrafenib-in-patients-with-recurrent-braf-v600e-mutated-malignant-glioma-and-leptomeningeal-disease
#5
Michael C Burger, Michael W Ronellenfitsch, Nadja I Lorenz, Marlies Wagner, Martin Voss, David Capper, Theophilos Tzaridis, Ulrich Herrlinger, Joachim P Steinbach, Gabriele Stoffels, Karl-Josef Langen, Christian Brandts, Christian Senft, Patrick N Harter, Oliver Bähr
BRAF V600E mutations occur frequently in malignant melanoma, but are rare in most malignant glioma subtypes. Besides, more benign brain tumors such as ganglioglioma, dysembryoblastic neuroepithelial tumours and supratentorial pilocytic astrocytomas, only pleomorphic xanthoastrocytomas (50-78%) and epitheloid glioblastoma (50%) regularly exhibit BRAF mutations. In the present study, we report on three patients with recurrent malignant gliomas harbouring a BRAF V600E mutation. All patients presented with markedly disseminated leptomeningeal disease at recurrence and had progressed after radiotherapy and alkylating chemotherapy...
October 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29026272/incidence-of-diabetes-mellitus-and-neoplasia-in-japanese-short-statured-children-treated-with-growth-hormone-in-the-genetics-and-neuroendocrinology-of-short-stature-international-study-genesis
#6
Susumu Yokoya, Tomonobu Hasegawa, Keiichi Ozono, Hiroyuki Tanaka, Susumu Kanzaki, Toshiaki Tanaka, Kazuo Chihara, Nan Jia, Christopher J Child, Katsuichiro Ihara, Jumpei Funai, Noriyuki Iwamoto, Yoshiki Seino
The primary goal of the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) was to assess the safety and effectiveness of Humatrope(®), a GH preparation, in the treatment of pediatric patients with short stature. We report our findings in the GH-treated Japanese pediatric population focusing on the incidence of type 2 diabetes (T2D) and occurrence of neoplasms. A total of 2,345 Japanese patients were assessed for safety. During a mean observation period of 3.2 yr, T2D occurred in 3 patients (0...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28970242/initial-investigation-into-microbleeds-and-white-matter-signal-changes-following-radiotherapy-for-low-grade-and-benign-brain-tumors-using-ultra-high-field-mri-techniques
#7
J-G Belliveau, G S Bauman, K Y Tay, D Ho, R S Menon
BACKGROUND AND PURPOSE: External beam radiation therapy is a common treatment for many brain neoplasms. While external beam radiation therapy adheres to dose limits to protect the uninvolved brain, areas of high dose to normal tissue still occur. Patients treated with chemoradiotherapy can have adverse effects such as microbleeds and radiation necrosis, but few studies exist of patients treated without chemotherapy. MATERIALS AND METHODS: Ten patients were treated for low-grade or benign neoplasms with external beam radiation therapy only and scanned within 12-36 months following treatment with a 7T MR imaging scanner...
September 28, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28967635/content-of-stem-tumor-cd133-cells-in-brain-neoplasms-of-different-histological-type
#8
N I Lisyaniy, D N Stanetskaya, A N Lisyaniy, L N Belskaya
Today, there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in tumors of human brain. The aim of the study was to analyze the content of CD133(+) cells in different brain tumors by immunofluorescence assay and immunohistochemical method. MATERIALS AND METHODS: The samples of different brain tumors removed during neurosurgical operations were studied for CD133 expression. RESULTS: Immunofluorescence assay of tumor imprints revealed CD133(+) cells in 40-85% of tumors regardless of histological type...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28962117/nearly-asymptomatic-intracranial-capillary-hemangiomas-a-case-report-and-literature-review
#9
Xiaoyu Xia, Haoju Zhang, Hongyan Gao, Yi Yang, Yiwu Dai, Yang Jiao, Jianghong He
The present study reported a nearly asymptomatic case of intracranial capillary hemangioma (ICHs), which are rare benign vascular tumors or tumor-like lesions. A 33-year-old female came to the hospital with a complaint of a slight but recurring morning headache concentrated in the left posterior occipital area. These headaches spontaneously resolved without any treatment. Computed tomography and magnetic resonance imaging revealed a mass inside the left occipital lobe. The patient refused to undergo conservative observation at home and insisted on radical therapy...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28945125/texture-analysis-of-magnetic-resonance-images-to-predict-histologic-grade-of-meningiomas-in-dogs
#10
Tommaso Banzato, Marco Bernardini, Giunio B Cherubini, Alessandro Zotti
OBJECTIVE To predict histologic grade of meningiomas in dogs via texture analysis (TA) of MRI scans of the brain and spinal cord. SAMPLE 58 sets of MRI scans of the brain and spinal cord of dogs with histologically diagnosed meningioma. PROCEDURES MRI sequences were divided into a training set and a test set, and results of histologic assessment were obtained. Tumors were histologically grouped as benign (stage I) or atypical-anaplastic (stage II or III). Texture analysis was performed by use of specialized software on T2-weighted (T2W) and pre- and postcontrast T1-weighted (T1W) images...
October 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28936429/clinical-pet-mri-in-neurooncology-opportunities-and-challenges-from-a-single-institution-perspective
#11
REVIEW
Lisbeth Marner, Otto M Henriksen, Michael Lundemann, Vibeke Andrée Larsen, Ian Law
PURPOSE: Magnetic resonance imaging (MRI) plays a key role in neurooncology, i.e., for diagnosis, treatment evaluation and detection of recurrence. However, standard MRI cannot always separate malignant tissue from other pathologies or treatment-induced changes. Advanced MRI techniques such as diffusion-weighted imaging, perfusion imaging and spectroscopy show promising results in discriminating malignant from benign lesions. Further, supplemental imaging with amino acid positron emission tomography (PET) has been shown to increase accuracy significantly and is used routinely at an increasing number of sites...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28932944/-cognitive-deficits-following-brain-tumor-radiation-therapy
#12
REVIEW
M Buthut, R Haussmann, A Seidlitz, M Krause, M Donix
Brain radiation is an important treatment option for malignant and benign brain diseases. The possible acute or chronic impact of radiation therapy on cognitive performance is important for daily functioning and quality of life. A detailed evaluation of cognitive impairment is important in the context of how to control disease progression. The susceptibility of the hippocampus to radiation-induced neuronal damage and its important role in memory highlight that therapeutic strategies require precision medicine...
September 20, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28924548/remodeling-the-blood-brain-barrier-microenvironment-by-natural-products-for-brain-tumor-therapy
#13
REVIEW
Xiao Zhao, Rujing Chen, Mei Liu, Jianfang Feng, Jun Chen, Kaili Hu
Brain tumor incidence shows an upward trend in recent years; brain tumors account for 5% of adult tumors, while in children, this figure has increased to 70%. Moreover, 20%-30% of malignant tumors will eventually metastasize into the brain. Both benign and malignant tumors can cause an increase in intracranial pressure and brain tissue compression, leading to central nervous system (CNS) damage which endangers the patients' lives. Despite the many approaches to treating brain tumors and the progress that has been made, only modest gains in survival time of brain tumor patients have been achieved...
September 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28884561/tanycytic-ependymoma-of-the-brain-stem-presentations-of-rare-cystic-disease-variants-and-review-of-literature
#14
Ekkehard M Kasper, Franziska M Ippen, Georgios A Maragkos, Matthew P Anderson, Rafael Rojas, Anand Mahadevan
BACKGROUND: Tanycytic ependymoma is a rare variant of ependymoma and management guidelines for patients with this disease are not established. METHODS: We performed a systematic search on Pubmed complimented by hand- searching citation lists to identify patients with pathologically confirmed tanycytic ependymoma. Signs and symptoms, radiological and specific pathological findings as well as reported treatment modalities and outcomes were recorded and analyzed. RESULTS: 51 studies involving a total of 77 patients were identified and included in this review...
September 7, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28883682/role-of-mri-in-diagnosis-of-ruptured-intracranial-dermoid-cyst
#15
Sefedin Muçaj, Mehmet Sahin Ugurel, Kreshnike Dedushi, Naser Ramadani, Naim Jerliu
INTRODUCTION: Intracranial dermoid cystic tumors account for <1% of all intracranial masses. CASE REPORT: A 52-year-old male, having headaches, nausea and is presented with a history of 2 episodes of new onset seizures. On presentation, the patient had a normal physical exam, including a complete neurological and cranial nerve exam. METHODS: Precontrast MRI; TSE/T2Wsequence in axial/coronal planes; 3D - HI-resolution T1W sagittal; FLAIR/T2W axial; FLAIR/T2W, Flash/T2W oblique coronal plane, GRE/T2W axial...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28862247/ectopic-adrenocorticotropic-hormone-syndrome-in-a-case-of-duodenal-neuroendocrine-tumor-presenting-with-liver-metastasis
#16
J Khare, S Daga, S Nalla, P Deb
Ectopic adrenocorticotropic hormone (ACTH) syndrome is an uncommon disorder and comprises about 15% of all patients with Cushing's syndrome (CS). Duodenal carcinoids are rare, indolent tumors usually associated with a benign progression. We hereby report a rare case of CS resulting from ectopic ACTH secretion from a duodenal neuroendocrine tumor (NET) presenting with liver metastasis. A 37-year-old female presented with abdominal discomfort and dyspepsia of 1-month duration. Ultrasound abdomen suggested a well-defined hypoechoic lesion in the left lobe of the liver, suggestive of neoplasia...
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28844928/angiomatous-meningioma-have-a-very-benign-outcome-despite-frequent-peritumoral-edema-at-onset
#17
Lingyang Hua, Shihai Luan, Haixia Li, Hongda Zhu, Hailiang Tang, Hanqiu Liu, Xiancheng Chen, Oliver Bozinov, Qing Xie, Ye Gong
OBJECTIVE: Angiomatous meningioma (AM) is a rare subtype of meningioma characterized by highly vascular tumor tissue comprised predominantly of variable sized hyalinized blood vessels. The aim is to evaluate the clinical, radiological features of AM and the long term prognosis in a single neurosurgical center. METHODS: A total of 93 patients underwent surgical resection of AMs between 2003 to 2008 were enrolled for analysis. Clinical information, treatment and radiological images were collected and analyzed; follow-up was carried out as well...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28840085/-pure-suprasellar-schwannoma-presented-with-communicating-hydrocephalus-a-case-report
#18
Tomoya Oishi, Seiya Takehara, Yasuhiro Yamamura, Mamoru Tomida, Shinji Ito, Ken Kuriki, Hiroki Namba
Schwannoma is a benign peripheral nerve sheath tumor originating from Schwann cells. Most intracranial schwannomas arise from vestibular nerve and schwannoma in the suprasellar region is extremely rare. A 64-year-old man presented with walking disturbance and blurred vision for three months. Lateral hemianopsia in the left eye and brachybasia were observed. Magnetic resonance imaging revealed a suprasellar tumor with strong contrast enhancement associated with communicating hydrocephalus. The cerebrospinal fluid tap test improved gait disturbance...
July 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/28834810/braf-v600e-mutations-occur-in-a-subset-of-glomus-tumors-and-are-associated-with-malignant-histologic-characteristics
#19
Nooshin Karamzadeh Dashti, Armita Bahrami, Seung J Lee, Sarah M Jenkins, Fausto J Rodriguez, Andrew L Folpe, Jennifer M Boland
Glomus tumors are rare mesenchymal neoplasms with a phenotype akin to the modified smooth muscle cells of the glomus body. Most are benign, but rare examples show malignant histologic characteristics and aggressive behavior. We recently encountered a malignant glomus tumor with BRAF V600E mutation. We sought to study a large cohort for this mutation, with particular attention to associated malignant histologic characteristics. Tumors were classified based on WHO criteria as benign, uncertain malignant potential (glomus tumors of uncertain malignant potential-GT-UMP), or malignant...
November 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28833600/clinicopathologic-features-and-pathogenesis-of-melanocytic-colonization-in-atypical-meningioma
#20
Mitra Dehghan Harati, Andrew Yu, Shino D Magaki, Mari Perez-Rosendahl, Kyuseok Im, Young K Park, Marvin Bergsneider, William H Yong
Only two prior cases of benign dendritic melanocytes colonizing a meningioma have been reported. We add a third case, describe clinicopathologic features shared by the three, and elucidate the risk factors for this very rare phenomenon. A 29 year-old Hispanic woman presented with headache and hydrocephalus. MRI showed a lobulated enhancing pineal region mass measuring 41 mm in greatest dimension. Subtotal resection of the mass demonstrated an atypical meningioma, WHO grade II, and the patient subsequently underwent radiotherapy...
August 18, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
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