keyword
MENU ▼
Read by QxMD icon Read
search

Brain Benign Tumors

keyword
https://www.readbyqxmd.com/read/29747056/brain-ameloblastoma-metastasis-or-local-extension-report-of-a-case-and-literature-review
#1
Jérémie Bettoni, Cécilia Neiva, Charlie Demarteleire, Sylvie Testelin, Bernard Devauchelle, Stéphanie Dakpé
Background Ameloblastoma is a rare benign odontogenic tumor with a metastasis rate estimated at 2% of cases, mainly involving the lung (80%) and lymph nodes (20%). Methods We hereby present the case of a 26 year old patient with a history of locally recurrent mandibular ameloblastoma who developed a temporal intracranial ameloblastoma tumor requiring a collaborative neurosurgical and maxillo-facial radical surgical approach. Conclusion Although ameloblastomas are histologically benign, the temporal topography questions the dissemination pathophysiology of the tumor (metastasis or local extension through temporal muscle fibers), mainly relevant in cases of multiple recurrences...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29737552/competing-endogenous-rna-network-crosstalk-reveals-novel-molecular-markers-in-colorectal-cancer
#2
Nehal Samir, Marwa Matboli, Hanaa El-Tayeb, Ahmed El-Tawdi, Mohmed K Hassan, Sherif El-Khamisy, Hesham A E El-Akkad, Mohamed G Ramadan, Tarek N Al-Belkini, Farid El-Asmar
The competing endogenous RNA networks play a pivotal role in cancer diagnosis and progression. Novel properstrategies for early detection of colorectal cancer (CRC) are strongly needed. We investigated a novel CRC-specific RNA-based integrated competing endogenous network composed of lethal3 malignant brain tumor like1 (L3MBTL1) gene, long non-coding intergenic RNA- (lncRNA RP11-909B2.1) and homo sapiens microRNA-595 (hsa-miRNA-595) using in silico data analysis. RT-qPCR-based validation of the network was achieved in serum of 70 patients with CRC, 40 patients with benign colorectal neoplasm, and 20 healthy controls...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29718388/the-use-of-hypofractionated-radiosurgery-for-the-treatment-of-intracranial-lesions-unsuitable-for-single-fraction-radiosurgery
#3
Jim Zhong, Robert H Press, Jeffrey J Olson, Nelson M Oyesiku, Hui-Kuo G Shu, Bree R Eaton
Stereotactic radiosurgery (SRS) is commonly used in the treatment of brain metastases, benign tumors, and arteriovenous malformations (AVM). Single-fraction radiosurgery, though ubiquitous, is limited by lesion size and location. In these cases, hypofractionated radiosurgery (hfSRS) offers comparable efficacy and toxicity. We review the recent literature concerning hfSRS in the treatment of brain metastases, benign tumors, and AVMs that are poorly suited for single-fraction SRS. Published retrospective analyses suggest that local control rates for brain metastases and benign tumors, as well as the rates of AVM obliteration, following hfSRS treatment are comparable to those reported for single-fraction SRS...
April 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29710367/spontaneous-intraventricular-hemorrhage-caused-by-sphenoid-meningioma
#4
Cherkaoui Mandour, Jawad Laaguili, Miloudi Gazzaz, Brahim El Mostarchid
INTRODUCTION:  Benign sphenoid meningioma presenting with an acute intraventricular hemorrhage is extremely uncommon. CASE REPORT:  We report a case of a 61-year-old man who was admitted after sudden onset of a severe headache. Brain computed tomography revealed a sphenoid meningioma with acute intraventricular hemorrhage. DISCUSSION:  Intraventricular hemorrhage caused by Meningiomas is infrequent. Several hypotheses have been proposed to explain the cause of hemorrhage...
April 30, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29682051/meningioma-in-fourth-ventricle-of-brain-a-case-report-and-literature-review
#5
Firooz Salehpour, Javad Aghazadeh, Amir Mohammad Bazzazi, Farhad Mirzaei, Amir Taha Eftekhar Saadat, Seyed Ahmad Naseri Alavi
Meningiomas are benign tumors origin from central nervous system. They usually involve cephalic, paravertebral soft tissues, skin and in rare cases in the ear, temporal bone, mandible, foot, lung, and mediastinum. In this case, we report an unusual case of meningioma which placed in the fourth ventricle. A 14-year-old man with seizure and headache referred to our ward. The magnetic resonance imaging reported bilateral acoustic neuroma and fourth ventricle meningioma. The patient was scheduled for total tumor resection and the histopathology revealed psammomatous type of meningioma...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29680903/the-expression-profile-of-pd-l1-and-cd8-lymphocyte-in-pituitary-adenomas-indicating-for-immunotherapy
#6
Peng-Fei Wang, Ting-Jian Wang, Ya-Kun Yang, Kun Yao, Zhuo Li, Yan Michael Li, Chang-Xiang Yan
BACKGROUND: Pituitary adenomas (PAs) are the second most common brain tumors, and mostly are benign tumors. However, there exists subtypes of PAs refractory to common treatments, and need novel therapy. Programmed death 1 (PD-1) blockade has shown durable objective response in a variety of malignancies, and the key predictive markers for this immunotherapy were PD-L1 and CD8+ tumor-infiltrating lymphocyte (TILs) expression. To evaluate the potential immunotherapy for PAs, we investigated the expression of these two immune markers in PAs...
April 21, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29668616/lung-metastases-from-intracranial-bleeding-meningioma-a-case-report
#7
Su Hu, Yaqi Zhang, Yue Sun, Yang Yu, Jia Wang, Hui Dai, Feng Sun, Chunhong Hu
RATIONALE: Meningioma is slow-growing benign neoplasm that derived from the meningothelial cells of the arachnoid mater, and it is the most common type of primary brain tumor. Although cases of extracranial metastatic meningioma have been reported previously, few cases have reported the concurrent occurrence of primary meningioma with intratumoral bleeding and lung metastases. Here we report a case of meningioma with concurrent intratumoral bleeding and lung metastases. PATIENT CONCERNS: The patient was admitted to our hospital with sudden left limb paralysis combined with complaints of headache and dizziness...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29625310/glioneuronal-heterotopia-presenting-as-a-cerebellopontine-angle-tumor-of-the-cranial-nerve-viii-case-report
#8
M Peris-Celda, C Giannini, F E Diehn, L J Eckel, B A Neff, J J Van Gompel
BACKGROUND: Vestibular schwannomas and meningiomas account for the great majority of lesions arising in the cerebellopontine angle (CPA). In this report, we present a case of glioneuronal heterotopia, also known as glioneuronal hamartoma, arising from the VIII cranial nerve, which is an extremely uncommon lesion. Important radiologic and surgical aspects are reviewed, which may help in early recognition and intraoperative decision making when these lesions are encountered. CASE DESCRIPTION: A healthy 29-year-old female presented with intermittent right facial numbness...
April 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29621097/applying-ddx3x-biomarker-to-discriminate-atypical-from-benign-meningiomas-in-tissue-microarray
#9
Wen-Chiuan Tsai, Dueng-Yuan Hueng, Chii-Ruey Lin, Thomas C K Yang, Shin Nieh, Hong-Wei Gao
Patients with atypical meningiomas have a higher recurrence rate and poorer prognosis than patients with benign meningeal tumors. However, differentiating atypical from benign meningiomas based on fragmented specimens from brain tumor biopsy is complicated. We tested the association of DDX3X cytoplasmic expression and World Health Organization grading system in various subtypes of meningiomas. In our study, DDX3X expression was evaluated immunohistochemically in 10 non-neoplastic brain tissues and 71 meningiomas...
April 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29617855/endoscopic-resection-of-an-intraventricular-tumor-with-second-window-indocyanine-green-2-dimensional-operative-video
#10
Frederick L Hitti, John Y K Lee
A 26-year-old woman presented to our clinic with years of headaches and mental clouding. She had a nonfocal neurological examination including benign ophthalmological examination. Head computed tomography and brain magnetic resonance imaging (MRI) demonstrated asymmetry of the lateral ventricles due to a lesion arising from the foramen of Monro. At the top of our differential diagnosis were choroid plexus tumor and colloid cyst. We offered the patient treatment via an endoscopic approach. Here, we demonstrate the feasibility of using tumor-localizing dyes such as indocyanine green (ICG) in conjunction with endoscopes equipped with lasers to localize and treat intraventricular lesions...
March 29, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29609083/constructional-apraxia-in-elderly-patients-with-brain-tumors-considerations-with-an-up-to-date-review-of-the-literature
#11
Giorgia Abete Fornara, Andrea Di Cristofori, Giulio Andrea Bertani, Giorgio Carrabba, Barbara Zarino
BACKGROUND: Constructional apraxia (CA) is a neuropsychological impairment of either basic perceptual and motor abilities, or executive functions, in absence of any kind of motor or perceptual deficit. Considering patients with focal brain tumors, CA is common in left or right parietal and parieto-occipital lesions. In neuropsychology, Rey-Osterrieth Complex Figure test (ROCF) (or parallel forms) is commonly used for the assessment of CA. This study stems from a clinical observation of a difficulty with CA tests for the majority of neurosurgical elderly patients without occipito-parietal lesions...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29606040/decision-making-algorithm-for-minimally-invasive-approaches-to-anterior-skull-base-meningiomas
#12
Malte Ottenhausen, Kavelin Rumalla, Andrew F Alalade, Prakash Nair, Emanuele La Corte, Iyan Younus, Jonathan A Forbes, Atef Ben Nsir, Matei A Banu, Apostolos John Tsiouris, Theodore H Schwartz
OBJECTIVE Anterior skull base meningiomas are benign lesions that cause neurological symptoms through mass effect on adjacent neurovascular structures. While traditional transcranial approaches have proven to be effective at removing these tumors, minimally invasive approaches that involve using an endoscope offer the possibility of reducing brain and nerve retraction, minimizing incision size, and speeding patient recovery; however, appropriate case selection and results in large series are lacking. METHODS The authors developed an algorithm for selecting a supraorbital keyhole minicraniotomy (SKM) for olfactory groove meningiomas or an expanded endoscopic endonasal approach (EEA) for tuberculum sella (TS) or planum sphenoidale (PS) meningiomas based on the presence or absence of olfaction and the anatomical extent of the tumor...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29587809/assessing-the-outcomes-of-everolimus-on-renal-angiomyolipoma-associated-with-tuberous-sclerosis-complex-in-china-a-two-years-trial
#13
Yi Cai, Hao Guo, Wenda Wang, Hanzhong Li, Hao Sun, Bing Shi, Yushi Zhang
BACKGROUND: Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder characterized by the development of numerous benign tumors. Renal angiomyolipoma (RAML) occur in up to 80% of TSC patients, which is a leading cause of TSC-related death in adult patients. The aim of the study was to evaluate the efficacy and safety profiles of everolimus in Chinese patients of TSC associated with RAML(TSC-RAML). METHODS: In this 2-years, nonrandomized, open-label trial, 18 patients of TSC-RAML, with at least one RAML 3 cm or larger in its longest diameter, were enrolled to assess the efficacy and safety of everolimus therapy in Chinese patients...
March 27, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29549848/results-of-lifespan-exposure-to-continuous-and-intermittent-extremely-low-frequency-electromagnetic-fields-elfemf-administered-alone-to-sprague-dawley-rats
#14
L Bua, E Tibaldi, L Falcioni, M Lauriola, L De Angelis, F Gnudi, M Manservigi, F Manservisi, I Manzoli, I Menghetti, R Montella, S Panzacchi, D Sgargi, V Strollo, A Vornoli, D Mandrioli, F Belpoggi
BACKGROUND: Up to now, experimental studies on rodents have failed to provide definitive confirmation of the carcinogenicity of extremely low frequency electromagnetic fields (ELFEMF). Two recent studies performed in our laboratory on Sprague-Dawley rats reported a statistically significant increase in malignant tumors of different sites (mammary gland, C-cells carcinoma, hemolymphoreticular neoplasia, and malignant heart Schwannoma) when ELFEMF exposure was associated with exposure to formaldehyde (50 mg/l) or acute low dose of γ-radiation (0...
July 2018: Environmental Research
https://www.readbyqxmd.com/read/29548058/meningiomas-overview-and-new-directions-in-therapy
#15
Nancy Wang, Matthias Osswald
The majority of meningiomas, the most common primary brain tumor, are considered to be benign, and characteristic magnetic resonance imaging features allow a preliminary diagnosis. Meningiomas can be classified in the World Health Organization system as grade I, II, or III, depending on various histological features. In many cases, observation is the preferred management option, although this means the absence of a histological diagnosis. If necessary, standard therapy consists of surgery with or without adjuvant radiation, depending on the tumor grade and the degree of resection...
February 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29530707/transient-focal-mri-abnormalities-after-status-epilepticus-showed-11c-methionine-uptake-with-pet-in-a-patient-with-cerebral-cavernous-malformation
#16
Taichi Ishiguro, Masayuki Nitta, Takashi Komori, Takashi Maruyama, Yoshihiro Muragaki, Takakazu Kawamata
BACKGROUND: Transient focal MRI abnormalities after status epilepticus (SE) are rarely seen in patients with benign brain tumors, and the underlying mechanism is still unknown. We report a rare case of cerebral cavernous malformation with transient focal MRI abnormalities around the tumor and accumulation of 11C-methionine on PET after SE. These findings mimicked those of a glioma because the MRI and methionine PET findings were similar. We also speculate about the cause of this phenomenon in relation to pathological findings of this case...
March 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29529279/nonclinical-safety-assessment-of-the-%C3%AE-secretase-inhibitor-avagacestat
#17
Frank J Simutis, Thomas P Sanderson, Gary D Pilcher, Michael J Graziano
The toxicity of avagacestat, a sulfonamide-based gamma (γ)-secretase inhibitor that was in development as a treatment for Alzheimer's disease, was evaluated in a comprehensive nonclinical toxicology program that included 6-month and 1-year repeat-dose toxicity studies in rats and dogs, respectively. There was a spectrum of mechanism-based changes attributed to inhibition of Notch signaling that regulates the differentiation and proliferation of cells throughout development and in adult tissues. In both rats and dogs, ovarian follicular degeneration and atrophy and a low incidence of granulosa cell hyperplasia and benign granulosa-thecal cell tumors were observed...
February 24, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29500070/screening-for-tsc1-and-tsc2-mutations-using-ngs-in-greek-children-with-tuberous-sclerosis-syndrome
#18
Anna Papadopoulou, Argyrios Dinopoulos, George Koutsodontis, Roser Pons, Pelagia Vorgia, Vasiliki Koute, Athanassios Vratimos, Dimitrios Zafeiriou
Tuberous Sclerosis Complex (TSC) is a rare neurocutaneous syndrome inherited by an autosomal dominant manner. The disorder is commonly manifested by the presence of multiple benign tumors located in numerous tissues, including the brain, heart, skin and kidneys. Seizures, autism, developmental and behavioral delay, as well as non-neurological phenotypic findings, are suggestive of TSC. The identification of one pathogenic mutation in either the TSC1 or TSC2 genes is considered to be an independent diagnostic criterion...
May 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29492130/diagnosis-treatment-and-management-strategy-of-meningioma-during-pregnancy
#19
Ahmet Gurhan Gurcay, Ismail Bozkurt, Salim Senturk, Atilla Kazanci, Oktay Gurcan, Omer Faruk Turkoglu, Ethem Beskonakli
The most common benign tumor of the brain is meningiomas. Usually diagnosed between the ages of 40-60, they are more common in women. Studies have shown a strong relationship between hormones and malignancies. Although meningiomas are slow-growing tumors of the brain, pregnancy seems to induce its growth speed. Studies concerning meningiomas and hormone relationship may explain the reason why symptoms during pregnancy flare. More specifically, the estrogen and progesterone receptor may take an active role through signal transduction in inducing the growth of the tumor...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29477104/presentation-of-a-hemangioblastoma-in-cavernous-sinus-an-extremely-rare-case-report
#20
A Tabibkhooei, A Fattahi, H Rahatlou
INTRODUCTION: Hemangioblastoma (HB) is a benign vascular tumor that accounts for about 2% of intracranial neoplasms. HB of the cavernous sinus (CS) is extremely rare. Only one report was found in the literature. PRESENTATION OF CASE: We present a 29-year-old female with progressive headache and she had right ptosis and right mild oculomotor nerve palsy. The brain Magnetic Resonance Imaging (MRI) revealed a right extra-axial 4 × 4 cm in right CS position. The patient was operated upon microscopically via sub-temporal approach through a right temporal craniotomy...
2018: International Journal of Surgery Case Reports
keyword
keyword
86531
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"