Dennyson Leandro M Fonseca, Igor Salerno Filgueiras, Alexandre H C Marques, Elroy Vojdani, Gilad Halpert, Yuri Ostrinski, Gabriela Crispim Baiocchi, Desirée Rodrigues Plaça, Paula P Freire, Shahab Zaki Pour, Guido Moll, Rusan Catar, Yael Bublil Lavi, Jonathan I Silverberg, Jason Zimmerman, Gustavo Cabral-Miranda, Robson F Carvalho, Taj Ali Khan, Harald Heidecke, Rodrigo J S Dalmolin, Andre Ducati Luchessi, Hans D Ochs, Lena F Schimke, Howard Amital, Gabriela Riemekasten, Israel Zyskind, Avi Z Rosenberg, Aristo Vojdani, Yehuda Shoenfeld, Otavio Cabral-Marques
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, and chronic respiratory disease). However, despite the well-known influence of age on autoantibody biology in health and disease, its impact on the risk of developing severe COVID-19 remains poorly explored. Here, we performed a cross-sectional study of autoantibodies directed against 58 targets associated with autoimmune diseases in 159 individuals with different COVID-19 severity (71 mild, 61 moderate, and 27 with severe symptoms) and 73 healthy controls...
August 24, 2023: NPJ Aging