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Naglaa Fathy Abd El-Aal, Rania Said Hamza, Mona Magdy
Angiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. Forty female CD-1 Swiss albino mice were used divided into 4 groups (10 mice each); control healthy, control infected untreated, PZQ-treated and ART-treated...
December 20, 2017: Acta Parasitologica
Seyed Esmaeil Khoshnam, Alireza Sarkaki, Layasadat Khorsandi, William Winlow, Mohammad Badavi, Hadi Fathi Moghaddam, Yaghoob Farbooda
Cerebral hypoperfusion induced by transient bilateral common carotid arteries occlusion (tBCCAO), is associated with deleterious alterations in several physiological parameters of the animals. This study aims to investigate the effects of vanillic acid (VA) on memory impairment, locomotion and exploratory deficits, as well as histological and hippocampal long-term potentiation (LTP) injuries induced by tBCCAO procedure followed by reperfusion (BCCAO/R) in rats. Adult male Wistar rats (250-300g) were divided randomly into four groups: Sham-Operated group "Sham"; Vehicle+BCCAO/R group "BCCAO/R"; Vehicle+ Vanillic acid group "VA"; VA (100mg/kg) +BCCAO/R group "VA +BCCAO/R"...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mohamed Fathi, Mohamed Ashry, Ali Salama, Magdy R Badr
No abstract text is available yet for this article.
October 16, 2017: Zygote: the Biology of Gametes and Early Embryos
Rezvan Shaddel, Javad Hesari, Sodeif Azadmard-Damirchi, Hamed Hamishehkar, Bahram Fathi-Achachlouei, Qingrong Huang
Protein-polysaccharide interactions offer opportunities for designing the new functional foods with applications in the food and pharmaceutical industries. In this work, we microencapsulated black raspberry water extracts by double emulsion technique prior to complex coacervation using gelatin and gum Arabic to diminish the instability of their anthocyanins (ANCs) as water soluble compounds, particularly under harsh processing and storage conditions. Subsequently, optical microscopy, moisture, hygroscopicity, solubility, particle size, loading capacity, zeta potential, color parameters (L*, a*, b*, C, H° and TCD), stability, Fourier transform infrared spectroscopy (FTIR), and thermal behavior were evaluated...
October 10, 2017: International Journal of Biological Macromolecules
Sara Sayad Fathi, Arash Zaminy
Peripheral nerve injury has remained a substantial clinical complication with no satisfactory treatment options. Despite the great development in the field of microsurgery, some severe types of neural injuries cannot be treated without causing tension to the injured nerve. Thus, current studies have focused on the new approaches for the treatment of peripheral nerve injuries. Stem cells with the ability to differentiate into a variety of cell types have brought a new perspective to this matter. In this review, we will discuss the use of three main sources of mesenchymal stem cells in the treatment of peripheral nerve injuries...
September 26, 2017: World Journal of Stem Cells
Dhaneshwaree Asem, Vincent Vineeth Leo, Ajit Kumar Passari, Mary Vanlalhruaii Tonsing, J Beslin Joshi, Sivakumar Uthandi, Abeer Hashem, Elsayed Fathi Abd Allah, Bhim Pratap Singh
The gastrointestinal (GI) habitat of ruminant and non-ruminant animals sustains a vast ensemble of microbes that are capable of utilizing lignocellulosic plant biomass. In this study, an indigenous swine (Zovawk) and a domesticated goat (Black Bengal) were investigated to isolate bacteria having plant biomass degrading enzymes. After screening and enzymatic quantification of eighty-one obtained bacterial isolates, Serratia rubidaea strain DBT4 and Aneurinibacillus aneurinilyticus strain DBT87 were revealed as the most potent strains, showing both cellulase and xylanase production...
2017: PloS One
Satomi Suzuki Uematsu, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Yasuhiro Igarashi, Ibrahim Fathi, Shigehito Miyagi, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto
BACKGROUND: Subcutaneous islet transplantation (SC Tx) is associated with minimal invasiveness, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Although the effectiveness of basic fibroblast growth factor (bFGF) was reported, the optimal procedures remain unclear. We sought to optimize the prevascularization procedures including the use of a novel scaffold, recombinant peptide (RCP). METHODS: Devices containing various amount of bFGF with/without heparin, or RCP were implanted into the subcutaneous space of diabetic C57BL/6 mice...
October 10, 2017: Transplantation
Maha Affes, Fathi Aloui, Fatma Hadrich, Slim Loukil, Sami Sayadi
BACKGROUND: This study aimed to investigate the effects of bacterial lipase on biogas production of anaerobic co-digestion of slaughterhouse wastewater (SHWW) and hydrolyzed grease (HG). A neutrophilic Staphylococcus xylosus strain exhibiting lipolytic activity was used to perform microbial hydrolysis pretreatment of poultry slaughterhouse lipid rich waste. RESULTS: Optimum proportion of hydrolyzed grease was evaluated by determining biochemical methane potential...
October 10, 2017: Lipids in Health and Disease
Samaneh Pirmoradi, Ezzatollah Fathi, Raheleh Farahzadi, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
Aging and losing cell survival is one of the main problems in cell therapy. Aging of Mesenchymal Stem Cells (MSCs) is associated with a rise in intracellular reactive oxygen species, decrease in telomerase reverse transcriptase (TERT) expression and finally eroded telomere ends. Given that the production of free radicals in the aging process is effective, the use of antioxidants can help in scavenging free radicals and prevent the aging of cells. The aim of this study is to evaluate the effects of curcumin on proliferation, aging and TERT expression of rat adipose tissue-derived stem cells (rADSC)...
October 10, 2017: Drug Research
Yang Wang, Jing Fu, Yining Zhang, Matthew Li, Fathy Mohamed Hassan, Guang Li, Zhongwei Chen
Exploring highly efficient bifunctional electrocatalysts toward the oxygen reduction and evolution reactions is essential for the realization of high-performance rechargeable zinc-air batteries. Herein, a novel nanofibrous bifunctional electrocatalyst film, consisting of metallic manganese sulfide and cobalt encapsulated by nitrogen-doped carbon nanofibers (CMS/NCNF), is prepared through a continuous electrospinning method followed by carbonization treatment. The CMS/NCNF bifunctional catalyst shows both comparable ORR and OER performances to those of commercial precious metal-based catalysts...
October 10, 2017: Nanoscale
Christopher R Gilbert, Rob Ely, Joelle T Fathi, Brian E Louie, Candice L Wilshire, Hannah Modin, Ralph W Aye, Alexander S Farivar, Eric Vallières, Jed A Gorden
OBJECTIVE: Lung cancer screening programs have become increasingly prevalent within the United States after the National Lung Screening Trial results. We aimed to review the financial impact after programmatic implementation of Advanced Registered Nurse Practitioner-led programs of Lung Cancer Screening and Tobacco Related Diseases, Incidental Pulmonary Nodule Clinic, and Tobacco Cessation Services. METHODS: We reviewed revenue from 2013 to 2016 by our nurse practitioner-led program...
September 13, 2017: Journal of Thoracic and Cardiovascular Surgery
Naglaa Fathy Alsalawy, Rania Kamal Darwish, Manal Mohamed Kamal, Ahmed ElSayed ElTaweel, Hend Ibrahim Shousha, Tamer Mahmoud Elbaz
BACKGROUND: Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) plays an important role in many cancers including hepatocellular carcinoma (HCC). The aim of this study is to investigate the association of the DR4 polymorphisms C626G (Thr209Arg, rs20575) and A683C (Glu228Ala, rs20576) with the occurrence of HCC in Egyptian patients chronically infected with HCV. METHODS: The study included 80 patients with HCV-related HCC (group 1) and 80 patients with HCV-related liver cirrhosis (group 2) who are naïve to treatment...
October 3, 2017: Journal of Medical Virology
Farkhonde Jamshidi, Glareh Fathi, Hannaneh Davoodzadeh
Introduction: Paraquat is the most important herbicide of bi-prides class which is used widely in agriculture part but in many countries such as Iran, this herbicide use for suicide. This study was conducted with the aim to investigating Paraquat poisoning in Khuzestan province of Iran. Material and methods: This study is a retrospective and statistic investigation in which 159 files of toxicity cases were investigated during 2004 to 2015. The patients were contacted to inquire into their health, after completing a questionnaire, the data was gathered and analyzed using SPSS software...
2017: Archiwum Medycyny Sa̧dowej i Kryminologii
Yadollah Fathi, Majid Barati, Mitra Zandiyeh, Saeed Bashirian
BACKGROUND: Operating room personnel are at high risk of needlestick injuries (NSIs) and exposure to blood and body fluids. OBJECTIVE: To investigate the predictors of NSIs preventive behaviors during surgery among operating room personnel based on a health belief model (HBM). METHODS: This cross-sectional study was conducted on 128 operating room personnel in Hamadan, western Iran. Participants were selected, by census sampling, from teaching hospitals, completed a self-reported questionnaire including demographic characteristics, knowledge and HBM constructs...
October 2017: International Journal of Occupational and Environmental Medicine
Faten Frikha, Mouna Snoussi, Sondes Briki, Fathi Karray, Zouhir Bahloul
No abstract text is available yet for this article.
September 29, 2017: Joint, Bone, Spine: Revue du Rhumatisme
Fathy M Salama, Khalid A Attia, Ahmed A Abouserie, Ahmed El-Olemy, Ebrahim Abolmagd
A spectroflurimetric method has been developed and validated for the selective quantitative determination of ledipasvir in presence of sofosbuvir. In this method the native fluorescence of ledipasvir in ethanol at 405nm was measured after excitation at 340nm. The proposed method was validated according to ICH guidelines and show high sensitivity, accuracy and precision. Furthermore this method was successfully applied to the analysis of ledipasvir in pharmaceutical dosage form without interference from sofosbuvir and other additives and the results were statistically compared to a reported method and found no significant difference...
August 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Tarek Fathy El-Moselhy, Peter Ayoub Sidhom, Eman Ahmed Esmat, Nageh Ahmed El-Mahdy
Resurgence to target L-type voltage-dependent calcium channels has been applied by the synthesis of two series of nifedipine analogues where the ortho- or a meta-nitrophenyl ring is retained. A pre-synthetic molecular docking study with a receptor model followed by molecular alignment has been performed on 47 compounds to predict the most active member. The IC50 values revealed that some of the compounds are similar to or more active than nifedipine. Substitution of groups at the 3- and 5-positions of the dihydropyridine (DHP) ring gave 3k, which is more active than nifedipine...
2017: Chemical & Pharmaceutical Bulletin
Amir T Fathi, Traci M Blonquist, Daniela Hernandez, Philip C Amrein, Karen K Ballen, Malgorzata McMasters, David E Avigan, Robin Joyce, Emma K Logan, Gabriela Hobbs, Andrew M Brunner, Christelle Joseph, Ashley M Perry, Meghan Burke, Tanya Behnan, Julia Foster, Meghan K Bergeron, Jenna A Moran, Aura Y Ramos, Tina T Som, Jessica Rae, Kaitlyn M Fishman, Kristin L McGregor, Christine Connolly, Donna S Neuberg, Mark J Levis
BACKGROUND: Cabozantinib, a tyrosine kinase inhibitor of FMS-like tyrosine kinase 3 (FLT3), MET, AXL, vascular endothelial growth factor receptor, and KIT, is approved for use in multiple malignancies. We assessed the safety and tolerability of cabozantinib in AML, given up-regulation of multiple relevant pathways. METHODS: Adults were eligible if they were 18 years old or older with relapsed/refractory AML or if they were 70 years old or older with newly diagnosed AML but were ineligible for conventional therapy...
September 28, 2017: Cancer
Ali Mekki, Fathi Aloui, Sami Sayadi
Organic matter amendments have been proposed as a means to enhance soil carbon stocks on degraded soils particularly under arid climate. Soil organic carbon (SOC) plays a critical role in terrestrial carbon cycling and is central to preserving soil quality. The effects of biowastes compost (BWC) on soil carbon storage were investigated. Besides, changes in soil organic matter (SOM) and even soil organic carbon (SOC) in BWC amended soils following different applications were studied. The added BWC quantities were as followed: BWC/Soil (weight/weight (w/w) respectively: 1/8, 1/4 and 1/2)...
September 25, 2017: Journal of the Air & Waste Management Association
Hesham Fathi Marei, Jeroen Donkers, Mohamed Mostafa Al-Eraky, Jeroen J G van Merrienboer
BACKGROUND: Virtual patients (VPs) can be sequenced with other instructional methods in different ways. AIM: To investigate the effect of sequencing VPs with lectures in a deductive approach, in comparison with an inductive approach, on students' knowledge acquisition, retention, and transfer. METHODS: For two different topics, 84 out of 87 students have participated in the lecture and VP sessions. Students from female and male campuses have been randomly assigned to one of the two learning approaches (deductive and inductive), yielding four experimental groups...
September 22, 2017: Medical Teacher
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