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https://www.readbyqxmd.com/read/29223450/pesticide-degrading-natural-multidrug-resistance-bacterial-flora
#1
REVIEW
Kirubakaran Rangasamy, Murugan Athiappan, Natarajan Devarajan, Gopinath Samykannu, Javid A Parray, K N Aruljothi, Nowsheen Shameem, Abdulaziz A Alqarawi, Abeer Hashem, Elsayed Fathi Abd Allah
Multidrug-resistant (MDR) bacteria are a growing threat to humans across the world. Antibiotic resistance is a global problem that has developed through continuous antibiotic use, combinatorial antibiotic use, pesticide-antibiotic cross-resistance, and horizontal gene transfer, as well as various other modes. Pesticide-antibiotic cross-resistance and the subsequent expansion of drug-resistant bacteria are critically documented in this review, the primary focus of which is to assess the impact of indiscriminate pesticide use on the development of microbial communities with parallel pesticide and multidrug resistance...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29222716/childhood-acute-disseminated-encephalomyelitis-an-egyptian-pilot-study
#2
Hamed Ahmed Elkhayat, Omnia Fathy El-Rashidy, Iman Ali Elagouza, Raghda Zaitoun, Yasser Abdel Azeem Abbas
Describing the variable clinical features, laboratory findings, neuroimaging findings, and treatments given to children who presented with ADEM and following them up both clinically and radiologically. 21 patients were recruited: 14 new cases, and 7 old ones presenting over the preceding 5 years (retrospective review of existing data). 11 males and 10 females, with a mean age of 4.4 years ± 2.7 SD, were included. All new patients were subject to full history, examination and a panel of investigations including MRI of the brain...
December 8, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29214046/high-resolution-bacterial-16s-rrna-gene-profile-meta-analysis-and-biofilm-status-reveal-common-colorectal-cancer-consortia
#3
Julia L Drewes, James R White, Christine M Dejea, Payam Fathi, Thevambiga Iyadorai, Jamuna Vadivelu, April C Roslani, Elizabeth C Wick, Emmanuel F Mongodin, Mun Fai Loke, Kumar Thulasi, Han Ming Gan, Khean Lee Goh, Hoong Yin Chong, Sandip Kumar, Jane W Wanyiri, Cynthia L Sears
Colorectal cancer (CRC) remains the third most common cancer worldwide, with a growing incidence among young adults. Multiple studies have presented associations between the gut microbiome and CRC, suggesting a link with cancer risk. Although CRC microbiome studies continue to profile larger patient cohorts with increasingly economical and rapid DNA sequencing platforms, few common associations with CRC have been identified, in part due to limitations in taxonomic resolution and differences in analysis methodologies...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29213108/the-potential-therapeutic-effect-of-melatonin-on-human-ovarian-cancer-by-inhibition-of-invasion-and-migration-of-cancer-stem-cells
#4
Maryam Akbarzadeh, Ali Akbar Movassaghpour, Hossein Ghanbari, Maryam Kheirandish, Nazila Fathi Maroufi, Reza Rahbarghazi, Mohammad Nouri, Nasser Samadi
There is an urgent need to identify targeting molecules to control invasion and metastasis in cancer patients. We first isolated cancer stem cells (CSCs) from SKOV3 ovarian cancer cells and then investigated the role of melatonin in invasiveness and migration of CSCs compared to SKOV3 cells. The proportion of CSCs in SKOV3 cells was as low as 1.28% with overexpression of both CD133 and CD44. The ability of spheroid formation along with SOX2 overexpression revealed a high self-renewal potential in isolated cells...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211404/management-of-long-segment-anterior-urethral-stricture-%C3%A2-8cm-using-buccal-mucosal-bm-graft-and-penile-skin-ps-flap-outcome-and-predictors-of-failure
#5
Gamal A Alsagheer, Atef Fathi, Mohamed Sayed Abdel-Kader, Ahmed M Hasan, Omar Mohamed, Osama Mahmoud, Ahmad Abolyosr
PURPOSE: To evaluate the surgical outcome and predictors of failure of substitution urethroplasty using either dorsal onlay buccal mucosal (BM) graft or ventral onlay penile skin flap (PS) for anterior urethral stricture ≥ 8cm. PATIENTS AND METHODS: Between March 2010 and January 2016, 50 patients with anterior urethral stricture ≥ 8 cm were treated at our hospital. The surgical outcome and success rate were assessed. The predictors of failure were analyzed using multivariate analysis...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29204180/cytotoxic-effects-of-the-newly-developed-chemotherapeutic-agents-17-aag-in-combination-with-oxaliplatin-and-capecitabine-in-colorectal-cancer-cell-lines
#6
Mahshid Mohammadian, Shima Zeynali, Anahita Fathi Azarbaijani, Mohammad Hassan Khadem Ansari, Fatemeh Kheradmand
The use of heat shock protein 90 inhibitors like 17-allylamino-17-demethoxy-geldanamycin (17-AAG) has been recently introduced as an attractive anticancer therapy. It has been shown that 17-AAG may potentiate the inhibitory effects of some classical anticolorectal cancer (CRC) agents. In this study, two panels of colorectal carcinoma cell lines were used to evaluate the effects of 17-AAG in combination with capecitabine and oxaliplatin as double and triple combination therapies on the proliferation of CRC cell lines...
December 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29203983/role-of-hepatic-resection-for-hcc-in-the-era-of-transplantation-an-experience-of-two-tertiary-egyptian-centers
#7
Ahhmed Senbel, Youssef Elmahdy, Sameh Roshdy, Ashraf Khater, Fayez Shehatoo, Omar Farouk, Adel Fathi, Emad Hamed, Sherif Kotb, Adel Denwer
The surgical treatments of hepatocellular carcinoma (HCC) in a cirrhotic liver include both hepatic resection and liver transplant. While the liver transplant is considered as a golden therapy, it has some obstacles including shortage of organs especially living donors, economic circumstances, and the progression of a tumor while waiting for the transplant so the second choice which is resection should have a role. In this study, 84 patients with HCC (who were legible for transplant according to Milan and extended selection criteria) were enrolled for hepatic resection...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29201310/a-neglected-markedly-displaced-medial-epicondyle-fracture-with-simultaneous-ulnar-nerve-palsy-in-an-adolescent
#8
Tamer Ahmed El-Sobky, John Fathy Haleem, Hossam Moussa Sakr, Ahmad Saeed Aly
Humeral medial epicondyle fractures constitute around 15% of pediatric elbow fractures. Up to 60% occur in association with elbow dislocations. Knowledge of potential imaging pitfalls when examining acute elbow fractures in children contributes significantly to accurate diagnosis. Nevertheless, management of missed pediatric medial epicondyle fractures has rarely been reported. We present an 11-year-old boy with a neglected and severely displaced medial epicondyle fracture with concurrent ulnar nerve palsy...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29201127/another-limping-child-an-interesting-diagnosis-journey
#9
Mehrnoush Hassas Yeganeh, Khosro Rahmani, Shokuh Hashemi, Seyed Hassan Tonekaboni, Reza Sinae, Mohammad Reza Fathi, Reza Shiari
Limp is described as any deviation from a normal gait pattern for the child's age. Limping takes many forms and is one of the most enigmatic complaints in pediatric medicine. It is never normal, and both benign and life-threatening illnesses can present with limp. The provisional diagnosis can be a challenge to establish even after history, physical, and laboratory examinations.
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29197789/nanostructured-lipid-carriers-for-improved-oral-delivery-and-prolonged-antihyperlipidemic-effect-of-simvastatin
#10
Heba A Fathi, Ayat Allam, Mahmoud Elsabahy, Gihan Fetih, Mahmoud El-Badry
The purpose of the current study is to develop nanostructured lipid carriers (NLCs) for the delivery of the antihyperlipidemic drug simvastatin (SIM) to increase its extremely low oral bioavailability (<5%) and prolong its antihyperlipidemic effect. NLCs were prepared via emulsification-solvent evaporation technique followed by ultrasonication, and the effect of composition of the nanocarriers on the particle size, size distribution, surface charge, entrapment efficiency, drug release kinetics and physical stability was extensively studied...
November 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29196412/a-phase-1-trial-of-vadastuximab-talirine-as-monotherapy-in-patients-with-cd33-positive-acute-myeloid-leukemia-aml
#11
Eytan M Stein, Roland B Walter, Harry P Erba, Amir T Fathi, Anjali S Advani, Jeffrey E Lancet, Farhad Ravandi, Tibor Kovacsovics, Daniel J DeAngelo, Dale Bixby, Stefan Faderl, Anand P Jillella, Phoenix Ho, Megan M O'Meara, Baiteng Zhao, Charles Biddle-Snead, Anthony S Stein
Vadastuximab talirine (SGN-CD33A, 33A) is an antibody-drug conjugate consisting of pyrrolobenzodiazepine dimers linked to a monoclonal antibody targeting CD33, which is expressed in the majority of acute myeloid leukemia (AML) patients. This phase 1 study (clinicaltrials.gov NCT01902329) evaluated the safety, pharmacokinetics, and preliminary activity of vadastuximab talirine and determined the recommended monotherapy dose in patients with relapsed or refractory AML. Additional expansion cohorts tested vadastuximab talirine in specific subpopulations of relapsed AML, and in a cohort of older, treatment-naïve patients...
December 1, 2017: Blood
https://www.readbyqxmd.com/read/29192303/association-between-ophthalmologist-age-and-unsolicited-patient-complaints
#12
Cherie A Fathy, James W Pichert, Henry Domenico, Sahar Kohanim, Paul Sternberg, William O Cooper
Importance: Understanding the distribution of patient complaints by physician age may provide insight into common patient concerns characteristic of early, middle, and late stages of careers in ophthalmology. Most previous studies of patient dissatisfaction have not addressed the association with physician age or controlled for other characteristics (eg, practice setting, subspecialty) that may contribute to the likelihood of patient complaints, unsafe care, and lawsuits. Objective: To assess the association between ophthalmologist age and the likelihood of generating unsolicited patient complaints (UPCs) among a cohort of ophthalmologists...
November 30, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29189996/zinc-sulphate-mediates-the-stimulation-of-cell-proliferation-of-rat-adipose-tissue-derived-mesenchymal-stem-cells-under-high-intensity-of-emf-exposure
#13
Ezzatollah Fathi, Raheleh Farahzadi
Unlike the role of mesenchymal stem cells (MSCs) in regenerative medicine, their application in cell therapy can be complicated by factors such as a reduction in the proliferation potential, senescent tendency of MSCs to expand, and an age-dependent decline in their number and functions. It was shown that there is an association between exposure to electromagnetic fields (EMFs) and response to stress, cell proliferation, aging, and cell death. Furthermore, the zinc ion, as an essential trace element, was reported to be involved in the regulation of the growth and cell proliferation...
November 30, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29186028/responsive-proteins-in-wheat-cultivars-with-contrasting-nitrogen-efficiencies-under-the-combined-stress-of-high-temperature-and-low-nitrogen
#14
Peerzada Yasir Yousuf, Elsayed Fathi Abd Allah, Mohd Nauman, Ambreen Asif, Abeer Hashem, Abdulaziz A Alqarawi, Altaf Ahmad
Productivity of wheat (Triticumaestivum) is markedly affected by high temperature and nitrogen deficiency. Identifying the functional proteins produced in response to these multiple stresses acting in a coordinated manner can help in developing tolerance in the crop. In this study, two wheat cultivars with contrasting nitrogen efficiencies (N-efficient VL616 and N-inefficient UP2382) were grown in control conditions, and under a combined stress of high temperature (32 °C) and low nitrogen (4 mM), and their leaf proteins were analysed in order to identify the responsive proteins...
November 29, 2017: Genes
https://www.readbyqxmd.com/read/29175802/review-ethnomedicinal-phytochemical-and-antibacterial-activities-of-medicinal-flora-of-pakistan-used-against-pseudomonas-aeruginosa-a-review
#15
Roqaia Bibi, Akash Tariq, Sakina Mussarat, Shahid Niaz Khan, Hazir Rahman, Elsayed Fathi Abd Allah, Riaz Ullah, Muhammad Adnan
Medicinal plants have been used from ancient time against different infectious diseases caused by microorganisms across the globe. The present review represents different medicinal plants of Pakistan used traditionally for the treatment of variety of ailments caused by Pseudomonas aeruginosa, their in-vitro activities against P. aeruginosa and phytochemistry. These plants were extracted with different solvents that showed good in-vitro activities against P. aeruginosa, due to the presence of active phytoconstituents including alkaloids, terpenoids etc...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29173143/the-role-of-grb2-in-cancer-and-peptides-as-grb2-antagonists
#16
Muhammad Ijaz, Muhammad Shahbaz, Wenjie Jiang, Abdel Hamid Fathy, Effat Un Nesa, Wang Feng Shan
Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein, which was originally discovered to accomplish basic cellular events such as cell growth, cell proliferation, and metabolism. However, recent studies evidenced that Grb2 was largely involved in multiple tumor malignancies. The mature Grb2 is a 217 amino acid sequence, which consists of one Src homology 2 (SH2) domain flanked by two Src homology 3 (SH3) domains. Using these binding motives, the ubiquitously expressed Grb2 acts as an intermediate between cell-surface activated receptors and downstream targets...
November 23, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29168312/curcumin-mediated-down-regulation-of-%C3%AE-v-%C3%AE-3-integrin-and-up-regulation-of-pyruvate-dehydrogenase-kinase-4-pdk4-in-erlotinib-resistant-sw480-colon-cancer-cells
#17
Samira Javadi, Kobra Rostamizadeh, Jalal Hejazi, Maliheh Parsa, Mojtaba Fathi
Erlotinib is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor, but the development of erlotinib resistance during chemotherapy can lead to treatment failure. To shed light on the erlotinib-resistant pathway, this study investigated the effect of combination therapy using curcumin- and erlotinib-loaded nanoparticles on the expression of αv β3 integrin and pyruvate dehydrogenase kinase 4 (PDK4) in an erlotinib-resistant SW480 colon cancer cell line. An erlotinib-resistant SW480 colon cancer cell line was produced by long-term exposure to erlotinib...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29159673/double-bundle-anterior-cruciate-ligament-reconstruction-is-better-than-single-bundle-reconstruction-in-terms-of-objective-assessment-but-not-in-terms-of-subjective-score
#18
Faisal Ahmed Hashem El-Sherief, Wael Abdelkarim Aldahshan, Yaser Elsayed Wahd, Ashraf Mohamed Abdelaziz, Hany Abdel Gawwad Soliman, Tohamy Goda Hassan, Hassan Fathy Elbehairy, Adel Hamed Awadallah
PURPOSE: A comparison of clinical outcomes between double-bundle (DB) and single-bundle (SB) anterior cruciate ligament (ACL) reconstruction for patients with ACL injury. METHODS: Sixty patients were treated with either SB (n = 30) or DB (n = 30) ACL reconstruction between 2011 and 2012. The hamstring tendons were autografted with suspensory fixation on the femoral side, while a bio-absorbable interference screw was used for fixation on the tibial side. These patients were evaluated using Lysholm score, International Knee Documentation Committee (IKDC) forms (both objective and subjective), Lachman test, pivot shift test, and KT 1000 arthrometer...
November 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29159144/thermoresponsive-graphene-oxide-starch-micro-nanohydrogel-composite-as-biocompatible-drug-delivery-system
#19
Mina Sattari, Marziyeh Fathi, Mansour Daei, Hamid Erfan-Niya, Jaleh Barar, Ali Akbar Entezami
Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-responsive materials, poly (N-isopropylacrylamide) (PNIPAAm) based hydrogels have been widely developed and their properties can be easily tailored by manipulating the properties of the hydrogel and the composite material...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/29153227/effect-of-changing-the-duration-of-keeping-sandbag-over-catheter-insertion-site-on-the-coronary-angiography-acute-complications-a-controlled-clinical-trial
#20
Mohammad Fathi, Sina Valiee, Parvin Mahmoodi
Transfemoral coronary angiography may cause acute and chronic complications. The aim of the present study was to assess the effects of changing the duration of keeping sandbag over the catheter insertion site on the acute complications of coronary angiography. This quasiexperimental study was conducted on 60 patients undergoing transfemoral coronary angiography. Participants were selected using convenience sampling and were randomly assigned to intervention (n = 30) or control group (n = 30). In the intervention group, the sandbag over the insertion site of catheter was taken off at the third hour, whereas in the control group, based on the routine care, sandbag was taken off at the sixth hour after the angiography...
December 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
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