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Amani Hajlaoui, Wafa Slimani, Molka Kammoun, Amira Sallem, Fathi El Amri, Anouar Chaieb, Mohamed Bibi, Ali Saad, Soumaya Mougou-Zerelli
BACHGROUND: The subtelomeric rearrangements are increasingly being investigated in cases of idiopathic intellectual disabilities (ID) and congenital abnormalities (CA) but are also thought to be responsible for unexplained recurrent miscarriage (RM). Such rearrangements can go unnoticed through conventional cytogenetic techniques and are undetectable even with high-resolution molecular cytogenetic techniques such as array comparative genomic hybridization (aCGH), especially when DNA of the stillbirth or families are not available...
June 2018: International Journal of Fertility & Sterility
Ahmed M Reyad, Ahmed Mamdouh, Elnisr Rashed, Atef Fathi, Osama Mahmoud, Ahmed Hasan
PURPOSE: The published literature shows controversies with regard to the treatment of choice for longer stricture. Augmented anastomotic urethroplasty (AAU) was described for long bulbar urethral strictures with an extended area of narrowing and fibrosis, the technique combines the advantages of both anastomosis and graft substitution. We aimed to compare the dorsal and ventral strip anastomosis in the AAU. METHODS: A retrospective Review was conducted at the Department of Urology, Sohag University Hospital; we included adult patients with long bulbar urethral strictures (> 2 cm) who underwent dorsal or ventral strip AAU...
July 2018: International Urology and Nephrology
Sepideh Zununi Vahed, Nazanin Fathi, Mohammad Samiei, Solmaz Maleki Dizaj, Simin Sharifi
Based on exceptional advantages of aptamers, increasing attention has been presented in the utilize of them as targeted ligands for cancer drug delivery. Recently, the progress of aptamer- targeted nanoparticles has presented new therapeutic systems for several types of cancer with decreased toxicity and improved efficacy. We highlight some of the promising formulations of aptamer-conjugated polymeric nanoparticles for specific targeted drug delivery to cancer cells. This review paper focuses on the current progresses in the use of the novel strategies to aptamer-targeted drug delivery for chemotherapy...
June 21, 2018: Journal of Drug Targeting
Ahmadreza Baghaie, Susanne Schnell, Ali Bakhshinejad, Mojtaba F Fathi, Roshan M D'Souza, Vitaliy L Rayz
Flow fields in cerebral aneurysms can be measured in vivo with phase-contrast MRI (4D Flow MRI), providing 3D anatomical magnitude images as well as 3-directional velocities through the cardiac cycle. The low spatial resolution of the 4D Flow MRI data, however, requires the images to be co-registered with higher resolution angiographic data for better segmentation of the blood vessel geometries to adequately quantify relevant flow descriptors such as wall shear stress or flow residence time. Time-of-Flight Magnetic Resonance Angiography (TOF MRA) is a non-invasive technique for visualizing blood vessels without the need to administer contrast agent...
June 15, 2018: Computers in Biology and Medicine
Masoud Hamerezaee, Somayeh F Dehghan, Farideh Golbabaei, Asad Fathi, Loghman Barzegar, Naseh Heidarnejad
Background: This study was conducted to investigate the heat stress and semen quality among male workers in a steel industry in Iran and investigate the relationship between heat stress indices and semen parameters. Methods: The study was conducted on workers exposed ( n  = 30) and unexposed ( n  = 14) to heat in a steel industry. After obtaining a brief biography of the selected employees, scrotal temperature, oral temperature, and environmental parameters were measured, and their semen samples were analyzed according to the procedure recommended by the World Health Organization...
June 2018: Safety and Health At Work
Evan C Chen, Amir T Fathi, Andrew M Brunner
Despite increasing understanding of the pathobiology of acute myeloid leukemia (AML), outcomes remain dismal particularly for patients over the age of 60 years, a population enriched for therapy-related AML (tAML) and secondary AML (sAML). For decades, the standard of care for AML has been the combination of cytarabine and daunorubicin, typically delivered in combination as "7 + 3" induction. In 2017, a liposomal-encapsulated combination of daunorubicin and cytarabine (CPX-351, Vyxeos) was approved by the US Food and Drug Administration (FDA) for use in the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs)...
2018: OncoTargets and Therapy
Eman R Abd Elgwad, Eman G Behiry, Fathy M Swailem, Seham G Ameen, Dalia M Abdelhasib, Rabab O Abd Elhamid
Introduction: Paraoxonases are a group of different forms enzymes that consist of three non-similar isoforms, PON1, PON2 and PON3 , which are located near to each other on the long arm of chromosome7. This study aims to investigate the association of a Q192R polymorphism of PON1 gene and statin response in patients with ischemic heart disease with dyslipidemia. Methods: The studied population included three hundred patients with coronary artery disease with dyslipidemia who were prescribed statins...
July 2018: Annals of Medicine and Surgery
Muneer A Malla, Anamika Dubey, Shweta Yadav, Ashwani Kumar, Abeer Hashem, Elsayed Fathi Abd Allah
Rapid industrialization and population explosion has resulted in the generation and dumping of various contaminants into the environment. These harmful compounds deteriorate the human health as well as the surrounding environments. Current research aims to harness and enhance the natural ability of different microbes to metabolize these toxic compounds. Microbial-mediated bioremediation offers great potential to reinstate the contaminated environments in an ecologically acceptable approach. However, the lack of the knowledge regarding the factors controlling and regulating the growth, metabolism, and dynamics of diverse microbial communities in the contaminated environments often limits its execution...
2018: Frontiers in Microbiology
Mohammed A El-Magd, Sara F Khalifa, Faisal Abdulrahman A Alzahrani, Abdelnaser A Badawy, Eman S El-Shetry, Lamess M Dawood, Mohammed M Alruwaili, Hedib A Alrawaili, Engi F Risha, Fathy M El-Taweel, Hany E Marei
β-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer's disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a large verity of neural subtypes. However, this neuroprotective effect was not studied on human olfactory bulb neural stem cells (hOBNSCs). Herein, we evaluated this effect and studied the underlying mechanisms. Exposure to Aβ25-35 (5 and 10 μM for 24 h) inhibited proliferation (revealed by downregulation of Nestin and Sox2 gene expression), and induced differentiation (marked by increased expression of the immature neuronal marker Map2 and the astrocyte marker Gfap) of hOBNSCs...
June 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
William Kromka, Michael Cameron, Ramin Fathi
BACKGROUND: Full-thickness skin grafting is a well-established technique in the reconstruction of various tissue defects and wounds. However, lack of uniformity in the procedure of closing and securing the grafts has led to a wide range of different techniques. OBJECTIVE: This article reviews the use of tie-over bolster dressings compared to basting sutures for the fixation and postsurgical immobilization of full-thickness skin grafts (FTSGs), discusses details of each method, and proposes a practice guideline for the closure of FTSGs...
June 1, 2018: Journal of Cutaneous Medicine and Surgery
Shaghayegh Keshani Dokht, Zahra Emam Djomeh, Mohammad Saeid Yarmand, Morteza Fathi
This paper aims to investigate chemical composition, rheological behavior, antioxidant activity and functional properties of Cordia myxa mucilage (CMM). Response surface methodology (RSM) demonstrated that optimum conditions for CMM extraction were as follow: ultrasound power of 99.37 W, extraction temperature of 88.05 °C and solid to water ratio of 16.25 w/w. CMM had, on average, 77.51% carbohydrate, 5.86% total ash, 8.90% protein, 6.90% moisture, and 1.00% fat. Due to a high level of nutrients, CMM can be suggested as a value added by-product in food and pharmaceutical systems...
June 14, 2018: International Journal of Biological Macromolecules
Mamdouh Ali Kotb, Mohamed Abdelmohsen Bedewi, Nasser M Aldossary, Gehan Mahmoud, Moheyeldeen Fathi Naguib
The objective of this study is to determine whether the cross sectional area (CSA) measurement of the median nerve at the wrist differ between carpal tunnel syndrome (CTS) in diabetic patients with and without diabetic polyneuropathy (DPN).This study included 44 patients with type II diabete millitus (DM) with CTS, 32 patients with CTS and DPN, 46 patients with idiopathic CTS, and 42 healthy subjects. Ultrasonographic measurement of the CSA of the median nerve was made at the level of the wrist, together with nerve conduction studies...
June 2018: Medicine (Baltimore)
Farag M Mosallam, Gharieb S El-Sayyad, Rasha M Fathy, Ahmed I El-Batal
Biosynthesis of nanoparticles by fermented plants using microbes is an eco-friendly and cost-effective process. In this study, we used the fungus Aspergillus orayzae for the fermentation process. The aqueous extract of fermented Lupin (AEFL) possesses the ability to reduce selenium ion in the presence of gamma rays evidenced by the color changes to red. Elemental composition, surface morphology, and identity of selenium nanoparticles (SeNPs) were verified by UV-Vis., TEM, DLS, XRD, EDX, SEM and FT-IR. Antimicrobial activity of SeNPs was tested towards multidrug-resistant (MDR) bacteria, and some pathogenic fungi...
June 9, 2018: Microbial Pathogenesis
Peter Geon Kim, Kelly Bridgham, Evan C Chen, Mahesh K Vidula, Olga Pozdnyakova, Andrew M Brunner, Amir T Fathi
The use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of therapy are not well understood. We retrospectively analyzed adult patients with newly diagnosed APL from 2004 through 2014 to identify incident AEs following treatment and contributing risk factors. Cardiac and neurologic AEs were more common and characterized in detail. Cardiac AEs such as the development of coronary artery disease (CAD), arrhythmias, and heart failure had a cumulative incidence of 6...
2018: Leukemia Research Reports
Abdalla M Etabbal, Fathi F Hussain, Mohamed O Benkhadoura, Abdalla M Banni
Objective: To report on our initial experience in the management of war-related penile injuries; proper diagnosis and immediate treatment of penile injuries is essential to gain satisfactory results. Besides treating primary wounds and restoring penile function, the cosmetic result is also an important issue for the surgeon. Patients and methods: The study was conducted in the Department of Urology at Benghazi Medical Center and comprised all patients who presented with a shotgun, gunshot or explosive penile injury between February 2011 and August 2017...
June 2018: Arab Journal of Urology
Mohammadamin Sadeghi, Mahsa Keshavarz-Fathi, Vickie Baracos, Jann Arends, Maryam Mahmoudi, Nima Rezaei
Cancer cachexia is a multi-factorial syndrome, which negatively affects quality of life, responsiveness to chemotherapy, and survival in advanced cancer patients. Our understanding of cachexia has grown greatly in recent years and the roles of many tumor-derived and host-derived compounds have been elucidated as mediators of cancer cachexia. However, cancer cachexia remains an unmet medical need and attempts towards a standard treatment guideline have been unsuccessful. This review covers the diagnosis, assessment, and treatment of cancer cachexia; the elements impeding the formulation of a standard management guideline; and future directions of research for the improvement and standardization of current treatment procedures...
July 2018: Critical Reviews in Oncology/hematology
Shirin Khajeh, Mohammad Reza Tohidkia, Ayuob Aghanejad, Tayebeh Mehdipour, Farzaneh Fathi, Yadollah Omidi
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). Hence, neutralizing G17-Gly activity by antibody entities can provide a potential therapeutic strategy in the patients with CRCs. To this end, we isolated fully human antibody fragments from a phage antibody library through biopanning against different epitopes of G17-Gly in order to obtain the highest possible antibody diversity. ELISA screening and sequence analysis identified 2 scFvs and 4 VL antibody fragments...
June 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Nujood Alzahrani, Nshwa Ashor, Traji Fathi, Dania Bukhari, Galila Zaher
Bone marrow transplantation is the definitive treatment of severe aplastic anemia; however, with the absence of this option, combined immunosuppressive therapy with antithymocyte globulin (ATG) and cyclosporine A is used as a first-line therapy. This case report highlights the possible delay in response to ATG protocol in treating aplastic anemia.
June 2018: Clinical Case Reports
Mohamed ElAttar, Ahmed El Naggar, Fahmy Fahmy Samir, Hossam Fathi
Background: Currently, correction of the first intermetatarsal angle associated with hallux valgus is done using two main categories of surgeries either a distal or a proximal first metatarsal osteotomy. The osteotomy-sparing technique using TigthRope ®device was developed to manage hallux valgus avoiding osteotomy complications. Our hypothesis was that osteotomy sparing technique using TightRope® implant would be suitable for moderate hallux valgus in young adult patients with strong larger bones giving good results with minimal complications...
June 2018: Journal of Orthopaedics
M A Wahab, A Shehta, M Elshoubary, A M Yassen, M Elmorshedi, T Salah, A M Sultan, O Fathy, W R Elsarraf, U Shiha, K Zalata, A N Elghawalby, M Eldesoky, A Monier, R Said, A M Elsabagh, M Ali, A Kandeel, U Abdalla, M Aboelella, M Elsadany, E E Abdel-Khalek, A Marwan, F M ElMorsi, R Adly
BACKGROUND: Living donor liver transplantation (LDLT) is considered a safe alternative to deceased donor liver transplantation (DDLT). In Egypt, DDLT program is still awaited, making LDLT the only hope for patients with end-stage liver disease, mainly due to chronic hepatitis C virus (HCV) infection. The current study is conducted to evaluate our experience of LDLT and discuss the lessons learned from 500 consecutive cases in HCV area. METHODS: We reviewed the data of patients who underwent LDLT at Gastrointestinal Surgery Center, Mansoura University during the period between May 2004 and March 2017...
June 2018: Transplantation Proceedings
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