keyword
MENU ▼
Read by QxMD icon Read
search

Fathi

keyword
https://www.readbyqxmd.com/read/28323527/design-synthesis-and-anticancer-evaluation-of-novel-pyrazole-pyrazolo-3-4-d-pyrimidine-and-their-glycoside-derivatives
#1
Ibrahim F Nassar, Ahmed F El Farargy, Fathy M Abdelrazek, Nasser S M Ismail
The chalcone derivatives 3a,b were cyclized upon reaction with thiourea to give the pyrazolo[3,4-d]pyrimidine derivatives 5a,b. Condensation of 5a,b and their hydrazide derivatives 8a,b with cyclic and acyclic glucose gave the condensed S- and N-glycosides 7a,b and 9a,b, respectively. Reaction of 3b with ethyl cyanoacetate followed by reaction with cyclic glucose afforded a mixture of the O- and/or N-glycoside isomers 12 and 13, respectively. The pyrazolo[3,4-c]pyrazole derivative 14 was also obtained from the reaction of 3b with hydrazine hydrate...
March 21, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28315358/isocitrate-dehydrogenase-idh-inhibition-as-treatment-of-myeloid-malignancies-progress-and-future-directions
#2
REVIEW
Vivek A Upadhyay, Andrew M Brunner, Amir T Fathi
Isocitrate dehydrogenase (IDH) is an essential metabolic enzyme. Over the last two decades, there has been a growing focus on the metabolic derangements that occur with IDH1 and IDH2 mutations. The altered IDH protein leads to accumulation of 2-hydroxyglutarate (2-HG), a metabolite with oncogenic activity via epigenetic mechanisms. The advent of IDH inhibitors has engendered hope in novel and targeted therapies in IDH1/2 mutant myeloid malignancies. We here summarize the basic physiology of IDH, the metabolic and oncogenic consequences of mutant IDH1/2, and the clinical significance of IDH inhibition in hematologic malignancies...
March 14, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28296777/interleukin-1%C3%AE-and-interleukin-1receptor-antagonist-polymorphisms-in-egyptian-children-with-febrile-seizures-a-case-control-study
#3
Salah Al Morshedy, Hosam F Elsaadany, Hany E Ibrahim, Ashraf M Sherif, Mohsen A A Farghaly, Mayy A N Allah, Heba Abouzeid, Shaimaa S A Elashkar, Mohammed E Hamed, Manar M Fathy, Atef M Khalil, Maha A Noah, Mohamed S Hegab, Ahmed R Ahmed, Mustafa I A Hashem, Ahmed A Emam, Heba G Anany, Boshra R Ibrahim, Heba H Gawish, Rehab M Nabil, Lobna Abdel Fattah, Salah F Alsayed
Febrile seizure is the most common seizure disorder of childhood. Of the pro-inflammatory cytokines, interleukin-1 is defined as the first endogenous pyrogen.We designed this study to investigate single-nucleotide polymorphisms (SNPs) situated at positions -31 (C/T), and -511 (C/T) of interleukin-1beta (IL-1β) gene promoter and interleukin-1receptor antagonist (IL-1RA) gene variable number of tandem repeats in intron 2 (VNTR); to determine whether these polymorphisms could be a marker of susceptibility to febrile seizures in Egyptian children and we also measured the serum level of IL-1β to assess its relation to such polymorphisms...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28296769/oral-magnesium-supplementation-improves-glycemic-control-and-lipid-profile-in-children-with-type-1-diabetes-and-hypomagnesaemia
#4
Doaaa Shahbah, Tamer Hassan, Saeed Morsy, Hosam El Saadany, Manar Fathy, Ashgan Al-Ghobashy, Nahla Elsamad, Ahmed Emam, Ahmed Elhewala, Boshra Ibrahim, Sherief El Gebaly, Hany El Sayed, Hanan Ahmed
Dietary supplementation with magnesium (Mg) in addition to classical therapies for diabetes may help in prevention or delaying of diabetic complications.We aimed to evaluate the status of serum Mg in children with type 1 diabetes and assessing its relationship to glycemic control and lipid profile. Then evaluating the effect of oral Mg supplementation on glycemic control and lipid parameters.We included 71 children at Pediatric Endocrinology Outpatient Clinic, Zagazig University, Egypt with type 1 diabetes and assessed HBA1c, lipid profile, and serum Mg at the start of study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28291960/trabeculectomy-with-ologen-versus-mitomycin-c-in-juvenile-open-angle-glaucoma-a-1-year-study
#5
Fathi El-Sayyad, Heba Magdy Ahmed El-Saied, Mohamad Amr Salah Eddin Abdelhakim
BACKGROUND: We assessed bleb morphology and the intraocular pressure (IOP)-lowering effect of trabeculectomy with ologen compared to mitomycin C (MMC) in juvenile open-angle glaucoma (JOAG). METHODS: This is a prospective interventional comparative study conducted on 40 eyes (20 patients) with medically uncontrolled JOAG, randomly operating one eye for trabeculectomy with ologen (group A: 20 eyes) and the other with MMC (group B: 20 eyes). IOP measurement, SITA standard perimetry, and spectral domain optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) thickness were all done pre- and postoperatively...
March 15, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28289609/the-regenerative-effect-of-bone-marrow-derived-stem-cells-in-spermatogenesis-of-infertile-hamster
#6
Akbar Vahdati, Alireza Fathi, Mehrdokht Hajihoseini, Ghaem Aliborzi, Ebrahim Hosseini
BACKGROUND: Infertility is a serious social problem in advanced nations, with male factor in half of all cases of infertility. This study was conducted to determine the regenerative effect of bone marrow-derived stem cells in spermatogenesis of infertile hamster. METHODS: Twelve adult male hamsters were equally divided into azoospermic and control groups. Busulfan was intraperitoneally used for induction of azoospermia, while the right testis was treated with bone marrow-derived stem cells (10(6) BM-SCs), labeled with sterile trypan blue, 35 days after busulfan injection...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28286847/protocol-adherence-in-prehospital-medical-care-provided-for-patients-with-chest-pain-and-loss-of-consciousness-a-brief-report
#7
Mostafa Mehrara, Nader Tavakoli, Marzieh Fathi, Babak Mahshidfar, Mohammad Amin Zare, Azita Asadi, Saeedeh Hosseinzadeh, Mehdi Safdarian
INTRODUCTION: Although many protocols are available in the field of the prehospital medical care (PMC), there is still a notable gap between protocol based directions and applied clinical practice. This study measures the rate of protocol adherence in PMC provided for patients with chest pain and loss of consciousness (LOC). METHOD: In this cross-sectional study, 10 educated research assistants audited the situation of provided PMC for non-traumatic chest pain and LOC patients, presenting to the emergency department of a tertiary level teaching hospital, compare to national recommendations in these regards...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28284725/altered-helper-t-cell-mediated-immune-responses-in-male-mice-conceived-through-in-vitro-fertilization
#8
Hiwa Karimi, Pooya Mahdavi, Shohreh Fakhari, Mohammad Reza Faryabi, Parisa Esmaeili, Omid Banafshi, Ebrahim Mohammadi, Fardin Fathi, Aram Mokarizadeh
A study using a mouse IVF model was conducted to examine the hypothesis that in vitro fertilization (IVF) treatment may lead to immune system alteration in the offspring. Phagocytic activity and lymphocyte proliferative responses to mitogen, alloantigen, and purified protein derivative (PPD) of Mycobacterium bovis were investigated in the splenocytes of BCG-treated male mice conceived by IVF or natural conception. Intracellular expression of T-bet and GATA3 in helper T-cell population were examined in both groups...
March 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28282990/validation-and-accuracy-of-intraoperative-ct-scan-using-the-philips-alluraxper-fd20-angiography-suite-for-assessment-of-spinal-instrumentation
#9
Edin Nevzati, Javier Fandino, Bawarjan Schatlo, Michel Heimberg, Serge Marbacher, Luca Remonda, Ali-Reza Fathi
BACKGROUND: With the concept of the hybrid operating room gaining popularity, the authors adapted a hybrid angiographic suite with intraoperative computed tomography (iCT) to evaluate accuracy of pedicle screw placement in spinal fusion. This retrospective review examines how well iCT detected extrapedicular screw violation, to then allow repositioning and potentially avoid revision surgery. METHODS: A total of 36 consecutive patients underwent pedicle screw placement in posterior cervical, thoracic, and lumbosacral spinal fusions...
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28282093/characterization-of-dna-duplex-unzipping-through-a-sub-2-nm-solid-state-nanopore
#10
Yao Lin, Xin Shi, Shao-Chuang Liu, Yi-Lun Ying, Qiao Li, Rui Gao, Farkhondeh Fathi, Yi-Tao Long, He Tian
Herein, the unzipping and translocation of DNA duplexes through a sub-2 nm silicon nitride (SiNx) solid-state nanopore have been demonstrated by well-resolved three-level blockades. In order to examine our observations, we applied a simple model which is applicable to the unzipping and translocation processes of DNA duplexes through solid-state nanopores. The generation of these highly recognizable signatures is an important step towards the real applications of solid-state nanopores in complex samples.
March 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28281934/integron-occurrence-is-linked-to-reduced-biocide-susceptibility-in-multidrug-resistant-pseudomonas-aeruginosa
#11
Ashraf A Kadry, Fathy M Serry, Amira M El-Ganiny, Ahmed M El-Baz
OBJECTIVE: Integrons are gene acquisition systems commonly found in bacterial genomes that play a major role in the dissemination of resistance to antibiotics. This work aimed to study the relationship between the presence of integrons and the reduced susceptibility of multidrug-resistant (MDR) Pseudomonas aeruginosa isolates towards different groups of biocides. METHODS: The antimicrobial susceptibility patterns of 104 clinical isolates were determined against different antibiotics by the disk diffusion method...
March 10, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28281204/erratum-to-effect-of-crystallinity-on-electrostatic-charging-in-drypowder-inhaler-formulations
#12
Jennifer Wong, Philip Chi Lip Kwok, Tim Noakes, Ali Fathi, Fariba Dehghani, Hak-Kim Chan
No abstract text is available yet for this article.
March 9, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28280914/differentiation-of-pityriasis-rubra-pilaris-from-plaque-psoriasis-by-dermoscopy
#13
N E Abdel-Azim, S A Ismail, E Fathy
Pityriasis rubra pilaris (PRP) and plaque psoriasis (PP) are two distinctive erythemato-squamous skin diseases that often have to be differentiated from each other and from other similar dermatoses. Dermoscopy has been proven to aid the clinical diagnosis of several inflammatory disorders, minimizing the need for skin biopsy. Our aim was to determine the dermoscopic patterns of PRP compared to PP and to assess the significance of certain dermoscopic criteria in the diagnosis of PRP. This case-control study included 11 patients with biopsy proven PRP and 25 patients with biopsy proven plaque psoriasis...
March 9, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28277156/maternal-self-efficacy-postpartum-depression-and-their-relationship-with-functional-status-in-iranian-mothers
#14
Fahimeh Fathi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand
Readiness to care for family, infant, and self are important during the postpartum period. The objective of this study was to determine the relationships of self-efficacy and postpartum depressive symptoms with functional status in randomly sampled Iranian mothers (n = 437). The study was cross-sectional and conducted in 2015. The mean (SD) of the total functional status score was 2.3 (0.2) out of a possible score of 1-4. The maximum and minimum scores in infant care were 4.0 and 2.2 and, in social and community activity, levels were 3...
February 7, 2017: Women & Health
https://www.readbyqxmd.com/read/28275859/gene-expression-of-mirna-138-and-cyclin-d1-in-oral-lichen-planus
#15
Noha A Ghallab, Rehab Fawzy Kasem, Safa Fathy Abd El-Ghani, Olfat G Shaker
OBJECTIVES: This study aimed to evaluate microRNA-138 (miR-138) gene expression and its target cyclin D1 (CCND1) gene and protein expression in oral lichen planus (OLP) mucosa in an attempt to investigate their possible roles in OLP immunopathogenesis. METHODS: Sixty oral biopsy specimens were harvested from 30 healthy subjects and 30 OLP patients, subdivided into reticular, atrophic, and erosive groups (n = 10 each). Samples were subjected to quantitative real-time polymerase chain reaction analysis for quantification of miR-138 and CCND1 relative gene expression and immunohistochemical analysis to determine CCND1 protein expression...
March 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28269736/huge-lactating-adenoma-of-the-breast-case-report
#16
Islam A Elzahaby, Saleh Saleh, Islam H Metwally, Adel Fathi, Khaled Atallah
No abstract text is available yet for this article.
March 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/28261953/prognostic-significance-of-cd133-and-ezrin-expression-in-colorectal-carcinoma
#17
Anan Fathi, Hala Mosaad, Samia Hussein, Mona Roshdy, Eman I Ismail
Despite the improvement in the diagnostic and the therapeutic modalities, colorectal cancer (CRC) morbidity and mortality remain high in both the developed and the developing countries. So, we are in a need to recognize new efficient diagnostic and prognostic biomarkers of CRC. That may help in providing individualized targeted therapy for this lethal malignancy. In this study, we investigated the expression and the prognostic significance of CD133 and ezrin mRNA and protein by quantitative RT-PCR and immunohistochemical analysis in primary CRC cases and the surrounding normal colonic mucosa...
March 5, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28260861/polyphosphoester-nanoparticles-as-biodegradable-platform-for-delivery-of-multiple-drugs-and-sirna
#18
Hadeel Elzeny, Fuwu Zhang, Esraa N Ali, Heba A Fathi, Shiyi Zhang, Richen Li, Mohamed A El-Mokhtar, Mostafa A Hamad, Karen L Wooley, Mahmoud Elsabahy
Delivery of multiple therapeutics and/or diagnostic agents to diseased tissues is challenging and necessitates the development of multifunctional platforms. Among the various strategies for design of multifunctional nanocarriers, biodegradable polyphosphoester (PPE) polymers have been recently synthesized via a rapid and simple synthetic strategy. In addition, the chemical structure of the polymer could be tuned to form nanoparticles with varying surface chemistries and charges, which have shown exceptional safety and biocompatibility as compared to several commercial agents...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28260468/tuberculosis-after-renal-transplant
#19
Samia Barbouch, Meriam Hajji, Imed Helal, Mondher Ounissi, Mohammed Mongi Bacha, Fathi Ben Hamida, Ezzedine Abderrahim, Taieb Ben Abdallah
Tuberculosis is one of the leading infections after renal transplant, particularly in developing countries where the incidence and prevalence in the general population are high. Diagnosis requires bacteriologic and histologic confirmation. Interactions among the antitubercular drugs and the immunosuppressive agents have to be considered while prescribing, and surveillance for adverse effects is required. Although rare, case reports are available on extrapulmonary tuberculosis in allograft recipients. Here, we present a 25-year-old kidney transplant recipient who was diagnosed with lymph node tuberculosis under uncommon circumstances but who had a good outcome...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260467/outcome-of-kidney-transplant-in-patients-with-polycystic-kidney-disease-a-single-center-study-in-tunisia
#20
Samia Barbouch, Meriam Hajji, Hafedh Hedri, Fethi El Younsi, Fathi Ben Hamida, Mohammed Mongi Bacha, Mondher Ounissi, Ezzedine Abderrahim, Taieb Ben Abdallah
OBJECTIVES: Autosomal dominant polycystic kidney disease is a common cause of end-stage renal disease and a common indication for renal transplant. This study was undertaken to evaluate the demographics, outcomes, and complications of renal transplant in patients with autosomal dominant polycystic kidney disease compared with other nephropathies. MATERIALS AND METHODS: In a retrospective case-control design, we reviewed the records of 7 patients with autosomal dominant polycystic kidney disease from a total of 701 renal transplant patients over a 30-year period (1986-2016)...
February 2017: Experimental and Clinical Transplantation
keyword
keyword
8653
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"