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https://www.readbyqxmd.com/read/29679594/design-and-synthesis-of-a-new-peptide-derived-from-fasciola-gigantica-cathepsin-l1-with-potential-application-in-serodiagnosis-of-fascioliasis
#1
Behnam Meshgi, Fatemeh Jalousian, Saeid Fathi, Zahra Jahani
Fascioliasis is a global parasitic disease that affects domestic animals and causes considerable economic losses in the process of domestic animal breeding in endemic regions. The cause of the disease involves a liver trematode of the genus Fasciola, which secretes materials into a host's body (mainly proteins) in order to protect it from the host's immune system. These materials can be involved in the migration, growth, and nutrition of the parasite. Among the expressive proteins of Fasciola, proteases have been introduced as the appropriate targets for diagnosis, treatment, and vaccination against parasites...
April 18, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29678380/performance-of-a-computer-aided-digital-dermoscopic-image-analyzer-for-melanoma-detection-in-1-076-pigmented-skin-lesion-biopsies
#2
Francis Del Rosario, Jessica M Farahi, Jesse Drendel, Talayesa Buntinx-Krieg, Joseph Caravaglio, Renee Domozych, Stephanie Chapman, Taylor Braunberger, Robert P Dellavalle, David A Norris, Ramin Fathi, Theodore Alkousakis
BACKGROUND: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. OBJECTIVE: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. METHODS: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29677595/bioherbicides-current-knowledge-on-weed-control-mechanism
#3
REVIEW
Ramalingam Radhakrishnan, Abdulaziz A Alqarawi, Elsayed Fathi Abd Allah
Weed control is a challenging event during crop cultivation. Integrated management, including the application of bioherbicides, is an emerging method for weed control in sustainable agriculture. Plant extracts, allelochemicals and some microbes are utilized as bioherbicides to control weed populations. Bioherbicides based on plants and microbes inhibit the germination and growth of weeds; however,few studies conducted in weed physiology. This review ascribes the current knowledge of the physiological changes in weeds that occur during the exposure to bioherbicides...
April 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29677017/spiradenocarcinoma-treated-with-mohs-micrographic-surgery
#4
Derek Beaulieu, Ramin Fathi, Adnan Mir, Rajiv I Nijhawan
No abstract text is available yet for this article.
April 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29673926/the-investigations-of-genetic-determinants-of-the-metabolic-syndrome
#5
REVIEW
Behdokht Fathi Dizaji
Metabolic syndrome is the aggregation of cardiovascular risk factors that increases the risk of type 2 diabetes and cardiovascular diseases. Family and twin studies, heritability spectrum for its components and different prevalence among ethnicities, have provided genetic susceptibility to the metabolic syndrome. The investigations of genetic base for the disorder have recognized numerous chromosomes, various DNA polymorphisms in candidate genes and many gene variants, that are associated with metabolic syndrome as an entity or its traits, which mostly are related to lipid metabolism...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29671193/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-mri-before-and-early-after-treatment-of-multiple-myeloma-a-prospective-comparative-study
#6
Mohammad Abd Alkhalik Basha, Maged Abdel Gelil Hamed, Rania Refaat, Mohamad Zakarya AlAzzazy, Manar A Bessar, Elshaimaa Mohamed Mohamed, Ayman F Ahmed, Heba Fathy Tantawy, Khaled Mohamed Altaher, Ahmed Ali Obaya, Amira Hamed Mohamed Afifi
OBJECTIVE: To determine the diagnostic accuracy of WB-MRI and 18 F-FDG PET/CT in detecting infiltration pattern, disease activity, and response to treatment in patients with multiple myeloma (MM). MATERIALS AND METHODS: Fifty-six patients with confirmed MM were included in the present study for pre-treatment evaluation. Among these individuals, 22 patients were available for the post-treatment evaluation of response to therapy. All patients were imaged with both WB-MRI and 18 F-FDG PET/CT...
April 18, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29671001/cervical-spine-prospective-feasibility-study-dynamic-flexion-extension-diffusion-tensor-weighted-magnetic-resonance-imaging
#7
Bawarjan Schatlo, Luca Remonda, Philipp Gruber, Javier Fandino, Veit Rohde, Ali-Reza Fathi, Jatta Berberat
PURPOSE: Diffusion tensor imaging (DTI) in flexion-extension may serve as a diagnostic tool to improve the sensitivity for detection of myelopathy. In this study, the feasibility and reproducibility of dynamic DTI in the cervical spinal cord was assessed in healthy volunteers and patients. METHODS: All subjects were examined in maximum neck flexion-extension in a 3T magnetic resonance imaging (MRI) scanner. Range of motion, space available for the spinal cord, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured and compared between the neck positions...
April 18, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29670365/prognostic-value-of-platelet-to-lymphocyte-ratio-in-pancreatic-cancer-a-comprehensive-meta-analysis-of-17-cohort-studies
#8
REVIEW
Yongping Zhou, Sijin Cheng, Abdel Hamid Fathy, Haixin Qian, Yongzhao Zhao
Background and aims: Several studies were conducted to explore the prognostic value of platelet-to-lymphocyte ratio (PLR) in pancreatic cancer and have reported contradictory results. This study aims to summarize the prognostic role of PLR in pancreatic cancer. Materials and methods: Embase, PubMed and Cochrane Library were completely searched. The cohort studies focusing on the prognostic role of PLR in pancreatic cancer were eligible. The overall survival (OS) and progression-free survival (PFS) were analyzed...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29668080/control-of-the-ethylene-signaling-pathway-prevents-plant-defenses-during-intracellular-accommodation-of-the-rhizobia
#9
Fathi Berrabah, Thierry Balliau, El Hosseyn Aït-Salem, Jeoffrey George, Michel Zivy, Pascal Ratet, Benjamin Gourion
Massive intracellular populations of symbiotic bacteria, referred to as rhizobia, are housed in legume root nodules. Little is known about the mechanisms preventing the development of defense in these organs although genes such as symCRK and DNF2 of the model legume Medicago truncatula are required for this control after rhizobial internalization in host nodule cells. Here we investigated the molecular basis of the symbiotic control of immunity. Proteomic analysis was performed to compare functional (wild-type) and defending nodules (symCRK)...
April 18, 2018: New Phytologist
https://www.readbyqxmd.com/read/29666465/molecular-epidemiology-of-lung-cancer-in-iran-implications-for-drug-development-and-cancer-prevention
#10
REVIEW
Zahra Fathi, Nicholas L Syn, Jian-Guo Zhou, Raheleh Roudi
Epidemiological studies undertaken over the past decades reveal a gradual but progressive increase in the incidence and mortality attributable to lung cancer in the Islamic Republic of Iran, a sovereign state geographically situated at the crossroads of Central Eurasia and Western Asia. We identified references published in English and Persian through searches of PubMed, EMBASE, Web of Science, Scopus, and the Scientific Information Database (SID)-a specialized Iranian database, which indexes Iranian scientific journals-between inception and 15 September 2017...
April 18, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29656994/an-ex-vivo-abomasal-ovine-model-to-study-the-immediate-immune-response-in-the-context-of-haemonchus-contortus-larval-stage
#11
Saeed El-Ashram, Cuiping Li, Fathi Abouhajer, Rashid Mehmood, Ibrahim Al Nasr, Yinghui Zhang, Tang Lu, Ding Yili, Xun Suo, Zhang Haoji, Zhili Li, Shujian Huang
We have set up an ex vivo ovine abomasal model, which can mimic the multicellular process to explore the early steps in haemonchine nematode infection using RNA-seq technology. Ovine abomasal explants were collected for histological and transcriptional analysis and supernatants collected to quantitate lactate dehydrogenase (LDH) enzymes. Atotal of 233 were substantially induced genes between L4 -inoculated and uninoculated-control tissues, respectively. However, a total of 14 were considerably down-regulated genes between the 51 aforementioned tissues...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29649620/allogeneic-hematopoietic-cell-transplantation-following-the-use-of-hypomethylating-agents-among-patients-with-relapsed-or-refractory-aml-findings-from-an-international-retrospective-study
#12
Maximilian Stahl, Michelle DeVeaux, Pau Montesinos Fernández, Raphaël Itzykson, Ellen K Ritchie, Mikkael A Sekeres, Navneet Majhail, John Barnard, Nikolai A Podoltsev, Andrew Brunner, Rami S Komrokji, Vijaya R Bhatt, Aref Al-Kali, Thomas Cluzeau, Valeria Santini, Gail J Roboz, Pierre Fenaux, Mark Litzow, Amir T Fathi, Sarah Perreault, Tae Kon Kim, Thomas Prebet, Norbert Vey, Vivek Verma, Guido Kobbe, Juan Bergua, Josefina Serrano, Steven D Gore, Amer M Zeidan
No abstract text is available yet for this article.
April 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29630085/ezh2-endothelin-1-and-cd34-as-biomarkers-of-aggressive-cervical-squamous-cell-carcinoma-an-immunohistochemical-study
#13
Anan Fathy, Aziza E Abdelrahman
OBJECTIVE: Cervical cancer has an increasing incidence in developing countries with a predominance of squamous cell carcinoma. In this work, we aimed to analyze the role of EZH2, Endothelin-1, and CD34 as indicators of the aggressiveness in cervical squamous cell carcinoma. MATERIAL AND METHOD: Immunohistochemical expression of EZH2, Endothelin-1, and CD34 was studied in 54 paraffin-embedded tissue specimens of cervical squamous cell carcinoma. Their correlation to the clinicopathologic features and the potential angiogenic role were analyzed...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29619847/scanning-electron-microscopic-characteristics-of-manually-loaded-and-preloaded-foldable-acrylic-intraocular-lenses
#14
Mahmoud Fathy Rateb, Zeiad Hasan Eldaly, Walid Saad Eldein Ibrahim, Ahmed Hasan Eldoghaimy
PURPOSE: To compare surface alterations between preloaded and manually loaded intraocular lens. METHODS: Scanning electron microscope was utilized to evaluate surface alteration and deposits in four different types of intraocular lenses: preloaded hydrophobic acrylic, preloaded hydrophilic acrylic, manually loaded hydrophobic acrylic, and manually loaded hydrophilic acrylic. Six lenses with different powers (+6 D, +22 D, and +29 D) were used from each category, to represent different thickness categories of the intraocular lenses...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29619378/nonsurgical-clinical-management-of-periapical-lesions-using-calcium-hydroxide-iodoform-silicon-oil-paste
#15
Qusai Al Khasawnah, Fathi Hassan, Deeksha Malhan, Markus Engelhardt, Diaa Eldin S Daghma, Dima Obidat, Katrin S Lips, Thaqif El Khassawna, Christian Heiss
Background: The study aim is to avoid tooth extraction by nonsurgical treatment of periapical lesion. It assesses healing progress in response to calcium hydroxide-iodoform-silicon oil paste (CHISP). Numeric Pain Rating Scale was used to validate the approach. Furthermore, CHISP was used to treat cystic lesions secondary to posttraumatic avulsion of permanent teeth. Materials and Methods: Over 200 patients with radicular cysts were treated with CHISP through the root canal...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29613848/investigation-of-physico-mechanical-properties-of-flexible-poly-vinyl-chloride-filled-with-antimony-trioxide-using-ionizing-radiation
#16
Mona Y Elnaggar, E S Fathy, Medhat M Hassan
Composites of polyvinyl chloride (PVC) with 2% calcium carbonate, 2% diethyl phthalate, 2% paraffin wax and 2% lead sulfate and different contents of antimony trioxide (Sb2 O3 ) prepared by melting and irradiated with gamma-ray have been considered. Assessment of the mechanical and thermal properties of the unirradiated and irradiated FPVC were completed utilizing elasticity (TS), Elongation at break (Eb) and TGA measurements. TS and thermal stability of FPVC displayed advanced improvement after addition of additives and this approach highlighted the efficiency of those ingredients on PVC...
April 3, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29609881/-ketamine-as-an-adjunct-to-bupivacaine-in-infra-orbital-nerve-block-analgesia-after-cleft-lip-repair
#17
Hala Saad Abdel-Ghaffar, Nawal Gad Elrab Abdel-Aziz, Mohamed Fathy Mostafa, Ahmed Kamal Osman, Nehad Mohamed Thabet
OBJECTIVES: We conducted this study to investigate the safety and analgesic efficacy of the addition of Ketamine to Bupivacaine in bilateral extra-oral infra-orbital nerve block in children undergoing cleft lip surgeries. METHODS: Sixty patients were randomly allocated into two groups (n=30), Group B received infra-orbital nerve block with 2mL of 0.25% Bupivacaine and Group BK received 0.5mg.kg-1 Ketamine for each side added to 1mL of 0.5% Bupivacaine solution diluted up to 2mL solution to 0...
March 30, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29608403/design-synthesis-molecular-docking-and-anti-hepatocellular-carcinoma-evaluation-of-novel-acyclic-pyridine-thioglycosides
#18
Galal H Elgemeie, Nahed M Fathy, Ayman B Farag, Sheikha A Alkhursani
A novel series of acyclic pyridine thioglycosides has been synthesized. Evaluation of the anti proliferative activity of these compounds against HEPG-2 cell lines (liver carcinoma cell lines) shows that most of the compounds have high anti-tumor activities especially 6b, 6c, 7b and 7c. Furthermore, in the modeling study, these compounds showed that they have high binding affinity with thymidylate synthase dihydrofolate reductase (TS-DHFR).
April 2, 2018: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29606745/production-and-characterization-of-vitamin-d-3-loaded-starch-nanoparticles-effect-of-amylose-to-amylopectin-ratio-and-sonication-parameters
#19
Elham Hasanvand, Milad Fathi, Alireza Bassiri
Two types of starches with different amylose to amylopectin ratios were used for the production of vitamin D3 loaded nanoparticles and effects of starch type, sonication time and temperature on physicochemical properties of nanocarriers were investigated. Both high amylose corn and potato starches nanocarriers had granular structure with particle size ranging from 32.04 to 99.2 nm and the encapsulation efficiency ranging from 22.34 to 94.8%. The results showed that potato starch nanoparticles had larger size, higher zeta potential, encapsulation efficiency and encapsulation load and lower polydispersity index values in comparison to high amylose corn starch nanoparticle...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29604612/multivariate-assessment-of-azo-dyes-biological-activity-parameters
#20
Gyöngyi Vastag, Suzana Apostolov, Borko Matijević, Fathi Assaleh
Lipophilicity as key molecular descriptor of potential biological activity for selected derivatives of azo dyes was determined mathematically, by using relevant software packages and by reversed-phase thin-layer chromatography (RPTLC) on C18 and cyano modified carriers in mixtures of water/n-propanol and water/acetone. The obtained chromatographic parameters, RM 0 and m, of the examined azo dyes were correlated with the standard measure of lipophilicity, log P, important pharmacokinetic predictors and selected toxicity parameters applying linear regression analysis...
March 26, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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