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https://www.readbyqxmd.com/read/28096117/commentary-on-an-anatomical-analysis-of-the-supratrochlear-artery-considerations-in-facial-filler-injections-and-preventing-vision-loss
#1
Ramin Fathi, Brian Biesman, Joel L Cohen
No abstract text is available yet for this article.
February 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28090779/preparation-and-in-vitro-in-vivo-evaluation-of-metformin-hydrochloride-rectal-dosage-forms-for-treatment-of-patients-with-type-ii-diabetes
#2
Abdel-Azim Zaghloul, Ahmad Lila, Fathy Abd-Allah, Aly Nada
BACKGROUND: Metformin hydrochloride (MtHCL) is an oral antidiabetic drug and has many other therapeutic benefits. It has poor bioavailability, narrow absorption window and extensive liver metabolism. Moreover, children and elders face difficulty to swallow the commercial oral tablets. OBJECTIVES: Preparation, in vitro/in vivo evaluation of MtHCL suppositories for rectal administration to solve some of these problems. METHODS: Suppository fatty bases (Witepsol®, Suppocire® and Massa®; different grades) and PEG bases 1000, 4000 and 6000 (different ratios), were used to prepare rectal suppository formulations each containing 500 mg drug...
January 16, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28087316/self-nanoemulsifying-lyophilized-tablets-snelts-for-flash-oral-transmucosal-delivery-of-vitamin-k-development-and-clinical-evaluation
#3
Khalid M El-Say, Tarek A Ahmed, Osama A A Ahmed, Khaled M Hosny, Fathy I Abd-Allah
Owing to limited solubility, vitamin K undergoes low bioavailability with large inter-individual variability after oral administration. This work aimed to prepare self-nanoemulsifying lyophilized tablets (SNELTs) for the flash oral transmucosal delivery of vitamin K. Twenty-one formulae of vitamin K self-nanoemulsifying drug delivery systems (SNEDDS) were prepared using different concentrations of vitamin K, Labrasol, and Transcutol according to mixture design. The SNEDDS was loaded on porous carriers and formulated as lyophilized tablets...
January 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28077881/a-pilot-study-of-penile-hemodynamics-in-men-with-penile-curvatures
#4
A A Zaazaa, I Fathy, O Ayman, A Hassanin, H Ghanem
Penile curvature (PC) is bothersome to the patient. PC is either congenital or acquired. In most of the circulatory system, blood flows in a laminar profile with minimal energy expenditure. When a fluid passes in a curved tube, the laminar profile is disturbed and changed into a turbulent flow. It increases the energy expenditure and reduces the flow. Turbulent flow may have a role in the development of an atherosclerotic plaque and in localizing its site. The aim of this research was to study penile hemodynamics before and after correction of PC...
January 12, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28069498/poly-glycerol-sebacate-poly-%C3%AE%C2%B5-caprolactone-blend-nanofibrous-scaffold-as-intrinsic-bio-and-immunocompatible-system-for-corneal-repair
#5
Sahar Salehi, Marta Czugala, Piotr Stafiej, Mohammadhossein Fathi, Thomas Bahners, Jochen S Gutmann, Bernhard B Singer, Thomas A Fuchsluger
: A major challenge in corneal tissue engineering and lamellar corneal transplantation is to develop synthetic scaffolds able to simulate the optical and mechanical properties of the native cornea. As a carrier, the graft scaffolds should provide the basis for anchorage, repair and regeneration. Although quite a number of scaffolds have been engineered to date, they have not been able to simultaneously recapitulate chemical, mechanical, and structural properties of the corneal extracellular matrix (ECM)...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28062430/rare-and-unusual-case-of-polyarteritis-nodosa-involving-the-gastrointestinal-tract-leading-to-bowel-gangrene
#6
Arvind Vashdev Jagwani, Nik Qisti Fathi, Ruhi Fadzlyana Jailani, Andee Dzulkarnaen Zakaria
Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis preferentially targeting medium-sized arteries and not related with glomerulonephritis or small vessel involvement. Clinical manifestations of PAN are multisystem. The gastrointestinal, renal, cardiac, musculoskeletal, skin and central nervous systems may be involved. The aetiology remains unknown, and the ensuing vasculitis may lead to aneurysm formation and thrombosis in any organs of the body with resultant ischaemia. PAN of the intestines is a relatively common manifestation of this disease but rarely causes bowel ischaemia resulting in necrosis...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28060008/acute-hiv-1-infection-is-associated-with-increased-plasma-levels-of-heme-oxygenase-1-ho-1-and-presence-of-ho-1-specific-regulatory-t-cells
#7
Mathieu Angin, Anahita Fathi, Melanie King, Mary B Ledoux, Alicja Piechocka-Trocha, Marcus Altfeld, Marylyn M Addo
OBJECTIVE: Heme-oxygenase-1 (HO-1) is an inducible stress-response protein with potent anti-inflammatory activity and recent data suggest a potentially beneficial role in HIV pathogenesis. We here investigated the impact of HO-1 and a novel subset of HO-1-specific CD8 regulatory T cells on virus-specific T cell immunity in HIV-1-infected individuals. METHODS: HO-1 protein levels were quantified in plasma from individuals at different stages of HIV-1 disease and longitudinally following primary HIV infection...
January 4, 2017: AIDS
https://www.readbyqxmd.com/read/28058237/lessons-learnt-from-pilot-field-test-of-a-comprehensive-advocacy-program-to-support-health-promoting-schools-project-in-iran
#8
Towhid Babazadeh, Behrouz Fathi, Abdolreza Shaghaghi, Hamid Allahverdipour
Background: Health promoting schools (HPS) project is currently being used in Iran but many challenges still lie ahead. The present study aimed, to test feasibility of implementing a comprehensive advocacy program (CAP) to overcome the obstacles and problems associated with the consummation of school health programs based on the HPS framework. Methods: This quasi-experimental study was performed through recruiting all schools that were enrolled in the national HPS program and located in Jolfa as the intervention group and all of the schools situated in the East Azerbaijan province as control...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28057407/bifunctional-conjugates-with-potent-inhibitory-activity-towards-cyclooxygenase-and-histone-deacetylase
#9
Idris Raji, Fatima Yadudu, Emily Janeira, Shaghayegh Fathi, Lindsey Szymczak, James Richard Kornacki, Kensei Komatsu, Jian-Dong Li, Milan Mrksich, Adegboyega K Oyelere
We herein disclose a series of compounds with potent inhibitory activities towards histone deacetylases (HDAC) and cyclooxygenases (COX). These compounds potently inhibited the growth of cancer cell lines consistent with their anti-COX and anti-HDAC activities. While compound 2b showed comparable level of COX-2 selectivity as celecoxib, compound 11b outperformed indomethacin in terms of selectivity towards COX-2 relative to COX-1. An important observation with our lead compounds (2b, 8, 11b, and 17b) is their enhanced cytotoxicity towards androgen dependent prostate cancer cell line (LNCaP) relative to androgen independent prostate cancer cell line (DU-145)...
December 24, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28056548/l-carnitine-contributes-to-enhancement-of-neurogenesis-from-mesenchymal-stem-cells-through-wnt-%C3%AE-catenin-and-pka-pathway
#10
Ezzatollah Fathi, Raheleh Farahzadi, Hojjatollah N Charoudeh
The identification of factors capable of enhancing neurogenesis has great potential for cellular therapies in neurodegenerative diseases. Multiple studies have shown the neuroprotective effects of L-carnitine (LC). This study determined whether neuronal differentiation of rat adipose tissue-derived mesenchymal stem cells (ADSCs) can be activated by LC. In this study, protein kinase A (PKA) and Wnt/β-catenin pathways were detected to show if this activation was due to these pathways. The expression of LC-induced neurogenesis markers in ADSCs was characterized using real-time PCR...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28054268/optimizing-the-phosphorus-use-in-cotton-by-using-csm-cropgro-cotton-model-for-semi-arid-climate-of-vehari-punjab-pakistan
#11
Asad Amin, Wajid Nasim, Muhammad Mubeen, Muhammad Nadeem, Liaqat Ali, Hafiz Mohkum Hammad, Syeda Refat Sultana, Khawar Jabran, M Habib Ur Rehman, Shakeel Ahmad, Muhammad Awais, Atta Rasool, Shah Fahad, Shah Saud, Adnan Noor Shah, Zahid Ihsan, Shahzad Ali, Ali Ahsan Bajwa, Khalid Rehman Hakeem, Asif Ameen, Amanullah, Hafeez Ur Rehman, Fahad Alghabar, Ghulam Hussain Jatoi, Muhammad Akram, Aziz Khan, Faisal Islam, Syed Tahir Ata-Ul-Karim, Muhammad Ishaq Asif Rehmani, Sajid Hussain, Muhammad Razaq, Amin Fathi
Crop nutrient management is an essential component of any cropping system. With increasing concerns over environmental protection, improvement in fertilizer use efficiencies has become a prime goal in global agriculture system. Phosphorus (P) is one of the most important nutrients, and strategies are required to optimize its use in important arable crops like cotton (Gossypium hirsutum L.) that has great significance. Sustainable P use in crop production could significantly avoid environmental hazards resulting from over-P fertilization...
January 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28047541/we-fg-bra-01-cancer-treatment-utilizing-photo-activation-of-psoralen-with-kv-x-rays
#12
M Oldham, S Yoon, B Meng, Z Fathi, W Beyer, J Adamson, D Alcorta, T Osada, K Lyerly, M Dewhirst, P Fecci, H Walder, N Spector
PURPOSE: This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with immunogenic anti-cancer potential. Psoralen therapies have been limited due to the requirement for psoralen activation by UVA light. X-PACT solves this challenge by activating psoralen with UV light emitted from novel non-tethered phosphors (co-incubated with psoralen) that absorb x-rays and reradiate (phosphoresce) at UV wavelengths...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045592/s-glycosides-in-medicinal-chemistry-novel-synthesis-of-cyanoethylene-thioglycosides-and-their-pyrazole-derivatives
#13
Galal Elgemeie, Nahed Fathy, Wafaa Zaghary, Ayman Farag
A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-configuration of these cyanoethylene thioglycosides.
January 3, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28042532/satellite-cells-contribution-to-exercise-mediated-muscle-hypertrophy-and-repair
#14
REVIEW
Behzad Bazgir, Rouhollah Fathi, Mojtaba Rezazadeh Valojerdi, Paul Mozdziak, Alireza Asgari
Satellite cells (SCs) are the most abundant skeletal muscle stem cells. They are widely recognized for their contributions to maintenance of muscle mass, regeneration and hypertrophy during the human life span. These cells are good candidates for cell therapy due to their self-renewal capabilities and presence in an undifferentiated form. Presently, a significant gap exists between our knowledge of SCs behavior and their application as a means for human skeletal muscle tissue repair and regeneration. Both physiological and pathological stimuli potentially affect SCs activation, proliferation, and terminal differentiation the former category being the focus of this article...
2017: Cell Journal
https://www.readbyqxmd.com/read/28040720/myelodysplastic-syndromes-version-2-2017-nccn-clinical-practice-guidelines-in-oncology
#15
Peter L Greenberg, Richard M Stone, Aref Al-Kali, Stefan K Barta, Rafael Bejar, John M Bennett, Hetty Carraway, Carlos M De Castro, H Joachim Deeg, Amy E DeZern, Amir T Fathi, Olga Frankfurt, Karin Gaensler, Guillermo Garcia-Manero, Elizabeth A Griffiths, David Head, Ruth Horsfall, Robert A Johnson, Mark Juckett, Virginia M Klimek, Rami Komrokji, Lisa A Kujawski, Lori J Maness, Margaret R O'Donnell, Daniel A Pollyea, Paul J Shami, Brady L Stein, Alison R Walker, Peter Westervelt, Amer Zeidan, Dorothy A Shead, Courtney Smith
The myelodysplastic syndromes (MDS) comprise a heterogenous group of myeloid disorders with a highly variable disease course. Diagnostic criteria to better stratify patients with MDS continue to evolve, based on morphology, cytogenetics, and the presence of cytopenias. More accurate classification of patients will allow for better treatment guidance. Treatment encompasses supportive care, treatment of anemia, low-intensity therapy, and high-intensity therapy. This portion of the guidelines focuses on diagnostic classification, molecular abnormalities, therapeutic options, and recommended treatment approaches...
January 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28040121/sublingual-misoprostol-versus-intravenous-oxytocin-in-reducing-bleeding-during-and-after-cesarean-delivery-a-randomized-clinical-trial
#16
Essam Rashad Othman, Margaret Fathy Fayez, Diaa Eldeen Mohamed Abd El Aal, Hazem Saad El-Dine Mohamed, Ahmed Mohammed Abbas, Mohammed Khairy Ali
OBJECTIVE: This study compares the efficacy of sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery. MATERIALS AND METHODS: A randomized clinical trial conducted on 120 pregnant women at term (37-40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either sublingual misoprostol 400 μg or intravenous infusion of 20 units of oxytocin after delivery of the neonate. The main outcome measures were blood loss at and 2 hours after cesarean delivery, change in hematocrit value, need for any additional oxytocic drugs, and drug-related side effects...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28039677/antixenosis-and-antibiosis-resistance-in-rice-cultivars-against-chilo-suppressalis-walker-lepidoptera-crambidae
#17
M A Tabari, S A A Fathi, G Nouri-Ganbalani, A Moumeni, J Razmjou
The striped stem borer, Chilo suppressalis (Walker) (Lepidoptera: Crambidae), is an important pest afflicting rice in most rice-growing countries in the world. Deliniating the categories of resistance in rice genotypes under field conditions could be helpful in managment of this pest. Two categories of resistance, antixenosis and antibiosis, were examined in ten popular and diverse rice genotypes of different origin that had been selected for their resistance to the striped stem borer in a previous study. Significant differences were found between genotypes for the number of egg masses, number of eggs, preference index, larval and pupal weight, larval development time, larval survival rate, larval mine length, and leaf trichome density...
December 31, 2016: Neotropical Entomology
https://www.readbyqxmd.com/read/28038999/carbonic-anhydrase-inhibition-boosts-the-antitumor-effects-of-imatinib-mesylate-via-potentiating-the-antiangiogenic-and-antimetastatic-machineries
#18
Amal A Abd-El Fattah, Hebatallah A Darwish, Nevine Fathy, Samia A Shouman
Carbonic anhydrase inhibitors have emerged in the past few years as an interesting candidate for the development of novel unconventional strategies. Despite their effect in tumor regression via inhibition of tumor acidification, their potential role is not yet fully elucidated. Herein, we investigated whether acetazolamide (AZ) could modulate imatinib (IM) anticancer activity, both in breast cancer cells (T47D) and in isolated tumor specimens of Ehrlich ascites carcinoma (EAC). The impact of this combination on angiogenesis was evidenced by decreasing PDGF-A expression and enhancing that of TSP-1...
December 28, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28034990/phase-i-study-of-the-aurora-a-kinase-inhibitor-alisertib-with-induction-chemotherapy-in-patients-with-acute-myeloid-leukemia
#19
Amir T Fathi, Seth A Wander, Traci M Blonquist, Andrew M Brunner, Philip C Amrein, Jeffrey Supko, Nicole M Hermance, Amity L Manning, Hossein Sadrzadeh, Karen K Ballen, Eyal C Attar, Timothy A Graubert, Gabriela Hobbs, Christelle Joseph, Ashley M Perry, Meghan Burke, Regina Silver, Julia Foster, Meghan Bergeron, Aura Y Ramos, Tina T Som, Kaitlyn M Fishman, Kristin L McGregor, Christine Connolly, Donna S Neuberg, Yi-Bin Chen
Aberrant expression of aurora kinase A is implicated in the genesis of various neoplasms, including acute myeloid leukemia. Alisertib, an aurora A kinase inhibitor, has demonstrated efficacy as monotherapy in trials of myeloid malignancy, and this efficacy appears enhanced in combination with conventional chemotherapies. In this phase I, dose-escalation study, newly diagnosed patients received conventional induction with cytarabine and idarubicin, after which alisertib was administered for 7 days. Dose escalation occurred via cohorts...
December 29, 2016: Haematologica
https://www.readbyqxmd.com/read/28033183/investigation-of-osteoinductive-effects-of-different-compositions-of-bioactive-glass-nanoparticles-for-bone-tissue-engineering
#20
AmirHossein Tavakolizadeh, Mehdi Ahmadian, MohammadHossein Fathi, Ali Doostmohammadi, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi
Bioactive glasses (BG) is one of the well-known materials that used as dental and bone implants, for this reason it is always interesting for researchers has been to increase BG efficiency in the bone tissue engineering. The aim of this work was to evaluate the osteoinductivity of BG different composition nanoparticles with SiO2-CaO-P2O5. The 45S, 58S, and 63S compositions were prepared via the sol-gel technique. Characterization techniques such as X-ray diffraction, field emission scanning electron microscopy (FE-SEM), and laser Doppler electrophoresis (LDE) were used...
December 26, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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