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https://www.readbyqxmd.com/read/28466053/analyzing-the-clinical-profile-of-swine-flu-influenza-a-h1n1-infection-in-central-india-a-retrospective-study
#1
Sameer Arbat, Mitesh Dave, Vinit Niranjane, Irfan Rahman, Ashok Arbat
Recently, India reported an increase in swine flu (influenza A H1N1) activity. There are limited studies on epidemiology of swine flu in Indian context. This study aims to analyze clinical and epidemiological profile of suspected swine flu cases in central India. 171 cases were included in a hospital based, observational, descriptive study conducted from December 2014 to April 2015. Demographics, clinical presentation and outcome of positive and negative cases were compared. Data was analyzed using STATA software...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28465592/gene-co-expression-network-analysis-identifies-porcine-genes-associated-with-variation-in-metabolizing-fenbendazole-and-flunixin-meglumine-in-the-liver
#2
Jeremy T Howard, Melissa S Ashwell, Ronald E Baynes, James D Brooks, James L Yeatts, Christian Maltecca
Identifying individual genetic variation in drug metabolism pathways is of importance not only in livestock, but also in humans in order to provide the ultimate goal of giving the right drug at the right dose at the right time. Our objective was to identify individual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (FLU) in swine liver. The population consisted of female and castrated male pigs that were sired by boars represented by 4 breeds. Progeny were randomly placed into groups: no drug (UNT), FLU or FBZ administered...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446785/possible-role-of-pandemic-ah1n1-swine-flu-virus-in-a-childhood-leukemia-cluster
#3
G Cazzaniga, L Bisanti, G Randi, S Deandrea, S Bungaro, F Pregliasco, D Perotti, F Spreafico, G Masera, M G Valsecchi, A Biondi, M Greaves
Leukemia accepted article preview online, 27 April 2017. doi:10.1038/leu.2017.127.
April 27, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28301280/panblok-h1-advax-h1n1-2009pdm-vaccine-insights-into-rapid-development-of-a-delta-inulin-adjuvanted-recombinant-pandemic-influenza-vaccine
#4
Yoshikazu Honda-Okubo, Harinda Rajapaksha, Dimitar Sajkov, David Gordon, Manon M J Cox, Nikolai Petrovsky
Timely vaccine supply is critical during influenza pandemics but is impeded by current virus-based manufacturing methods. The 2009 H1N1/2009pdm 'swine flu' pandemic reinforced the need for innovation in pandemic vaccine design. We report on insights gained during rapid development of a pandemic vaccine based on recombinant haemagglutinin (rHA) formulated with Advax™ delta inulin adjuvant (Panblok-H1/Advax). Panblok-H1/Advax was designed and manufactured within 1 month of the pandemic declaration by WHO and successfully entered human clinical testing in under 3 months from first isolation and sequencing of the novel pandemic virus, requiring several major challenges to be overcome...
June 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28260567/between-securitisation-and-neglect-managing-ebola-at-the-borders-of-global-health
#5
Mark Honigsbaum
In 2014 the World Health Organization (WHO) was widely criticised for failing to anticipate that an outbreak of Ebola in a remote forested region of south-eastern Guinea would trigger a public health emergency of international concern (pheic). In explaining the WHO's failure, critics have pointed to structural restraints on the United Nations organisation and a leadership 'vacuum' in Geneva, among other factors. This paper takes a different approach. Drawing on internal WHO documents and interviews with key actors in the epidemic response, I argue that the WHO's failure is better understood as a consequence of Ebola's shifting medical identity and of triage systems for managing emerging infectious disease (EID) risks...
April 2017: Medical History
https://www.readbyqxmd.com/read/28252630/-pharmacoepidemiological-study-of-the-course-of-influenza-and-other-acute-respiratory-viral-infections-in-risk-groups
#6
V A Bulgakova, A A Poromov, A I Grekova, N Yu Pshenichnaya, E P Selkova, N I Lvov, I A Leneva, I V Shestakova, V V Maleev
AIM: To identify risk factors (RFs) for the development of bacterial complications and the prolonged course of influenza and other acute respiratory viral infections (ARVIs) among inpatients treated in Russian healthcare facilities in the post-pandemic period; to determine the clinical presentation of the disease (flu-like syndrome) in risk-group people and to evaluate the efficacy of antiviral therapy with arbidol (umifenovir). MATERIAL AND METHODS: The investigators retrospectively analyzed randomly selected medical records of inpatients with influenza and other ARVI in 88 hospitals from 50 regions of the Russian Federation: those of 3532 and 1755 patients in the 2010-2011 and 2014-2015 seasons, respectively, by applying parametric and nonparametric statistical methods...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28202448/sixty-seconds-on-swine-flu-vaccine
#7
Anne Gulland
No abstract text is available yet for this article.
February 15, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28057521/biodegradable-nanoparticle-delivery-of-inactivated-swine-influenza-virus-vaccine-provides-heterologous-cell-mediated-immune-response-in-pigs
#8
Santosh Dhakal, Jagadish Hiremath, Kathryn Bondra, Yashavanth S Lakshmanappa, Duan-Liang Shyu, Kang Ouyang, Kyung-Il Kang, Basavaraj Binjawadagi, Jonathan Goodman, Kairat Tabynov, Steven Krakowka, Balaji Narasimhan, Chang Won Lee, Gourapura J Renukaradhya
Swine influenza virus (SwIV) is one of the important zoonotic pathogens. Current flu vaccines have failed to provide cross-protection against evolving viruses in the field. Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable FDA approved polymer and widely used in drug and vaccine delivery. In this study, inactivated SwIV H1N2 antigens (KAg) encapsulated in PLGA nanoparticles (PLGA-KAg) were prepared, which were spherical in shape with 200 to 300nm diameter, and induced maturation of antigen presenting cells in vitro...
January 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27790597/knowledge-and-awareness-regarding-swine-influenza-a-h1n1-virus-infection-among-dental-professionals-in-india-a-systematic-review
#9
REVIEW
Ramandeep Singh Gambhir, Prabh Roohan Pannu, Tarun Nanda, Gagandeep Arora, Amanpreet Kaur
INTRODUCTION: Swine flu or Influenza A (H1N1) flu is the most recent of the pandemic disease that has affected the world's population. We, as health care providers should feel responsible for reducing the transmission of influenza. AIM: To conduct a systematic review of observational studies and to assess dental professionals' knowledge and awareness regarding swine flu. MATERIALS AND METHODS: Relevant cross-sectional observational studies were included in the systematic review to assess the level of knowledge and awareness regarding swine flu among dental professionals...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27759342/a-study-of-outbreak-of-swine-flu-h1n1-in-north-west-zone-of-rajasthan-current-status-2015
#10
Surendra Kumar
BACKROUND: The outbreak of H1N1 virus had previously reported in India during 2009 flu pandemic. In 2015, the outbreak became widespread throughout India. The states of Gujarat and Rajasthan are severely elected. We studied an outbreak of H1N1 Virus in north-west zone of Rajasthan 2015. OBJECTIVE: To demonstrate the current epidemiological scenario of swine flu (H1N1) in north-west zone of Rajasthan with different demographic factors. METHODS: We screened total 6390 patients...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27741319/cross-neutralising-nanobodies-bind-to-a-conserved-pocket-in-the-hemagglutinin-stem-region-identified-using-yeast-display-and-deep-mutational-scanning
#11
Tiziano Gaiotto, Simon E Hufton
Cross-neutralising monoclonal antibodies against influenza hemagglutinin (HA) are of considerable interest as both therapeutics and diagnostic tools. We have recently described five different single domain antibodies (nanobodies) which share this cross-neutralising activity and suggest their small size, high stability, and cleft binding properties may present distinct advantages over equivalent conventional antibodies. We have used yeast display in combination with deep mutational scanning to give residue level resolution of positions in the antibody-HA interface which are crucial for binding...
2016: PloS One
https://www.readbyqxmd.com/read/27729839/identification-of-suitable-natural-inhibitor-against-influenza-a-h1n1-neuraminidase-protein-by-molecular-docking
#12
Maheswata Sahoo, Lingaraja Jena, Surya Narayan Rath, Satish Kumar
The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27728655/clinical-profile-of-swine-flu-h1n1-study-of-60-cases
#13
S P Abiramy, K Vengadakrishnan, Priyadharshini, Aishwarya
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27658945/swine-flu-vaccine-is-unlikely-to-raise-risk-of-overall-birth-defects-study-finds
#14
Jacqui Wise
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27647955/successfully-managing-swine-flu-h1n1-2015-and-the-way-ahead-the-rajasthan-model
#15
Amita Kashyap, Monika Rathore, Ashok Panagariya
No abstract text is available yet for this article.
July 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27597136/spontaneous-adverse-drug-reaction-reports-for-neonates-and-infants-in-the-uk-2001-2010-content-and-utility-analysis
#16
Daniel B Hawcutt, Nicki-Jayne Russell, Hannah Maqsood, Koushan Kouranloo, Simon Gomberg, Catriona Waitt, Andrew Sharp, Andrew Riordan, Mark A Turner
AIMS: The UK Medicines and Healthcare products Regulatory Agency (MHRA) runs a national spontaneous reporting system (Yellow Card [YC] Scheme) to collect 'suspected' adverse drug reaction (ADR) data. We aim to describe the content and utility of YC reports received for patients aged <2 years. METHODS: Data on all ADRs reported using YC in infants aged <2 years from the years 2001-10 were supplied by the MHRA. RESULTS: For infants age <2 years, 3496 suspected ADRs were reported using YC (paternal medication pre-conception n = 3, transplacental n = 246, transmammary n = 30, neonates n = 97, infant n = 477, and vaccinations n = 2673), averaging 0...
December 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27552392/what-s-in-the-literature
#17
Nicholas J Silvestri, Gil I Wolfe, David Lacomis, Mark B Bromberg
The Guillain-Barré syndrome (GBS) is one of the few neuropathies well known to the general public, in part because of its association with swine flu vaccinations in 1976. GBS has again reached the general public with its possible association with Zika virus. The virus, borne by infected Aedes aegypti mosquitos, is being linked to birth defects when pregnant women are bitten and infected. There are early reports also linking GBS to Zika infection, which could expose a wider range of infected people to the neuropathy...
September 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27381724/learning-to-trust-flu-shots-quasi-experimental-evidence-from-the-2009-swine-flu-pandemic
#18
Jürgen Maurer, Katherine M Harris
This paper studies consumer learning in influenza vaccination decisions. We examine consumer learning in influenza vaccine demand within a reduced form instrumental variable framework that exploits differences in risk characteristics of different influenza viruses as a natural experiment to distinguish the effects of learning based on previous influenza vaccination experiences from unobserved heterogeneity. The emergence of a new virus strain (influenza A H1N1/09) during the 2009 'Swine flu' pandemic resulted in two different vaccines being recommended for distinct population subgroups with some people, who were not usually targeted by seasonal vaccination programs, being specifically recommended for the new Swine flu vaccine...
September 2016: Health Economics
https://www.readbyqxmd.com/read/27344473/knowledge-attitude-and-anxiety-towards-pandemic-flu-a-potential-bio-weapon-among-health-professionals-in-indore-city
#19
Prashant Mishra, Upendra Singh Bhadauria, Pralhad L Dasar, Sandesh N, Sandeep Kumar, Afsheen Lalani, Pubali Sarkar, Astha Chauhan, Shaijal Godha, Shaleen Vyas
BACKGROUND: Flu is one of the oldest medical concerns, causing high mortality rates among humans. Swine flu has not only emerged as a fatal disease omong Indian population but has also created havoc among various sections of society. OBJECTIVE: To determine Knowledge, Attitude and Anxiety towards pandemic flu a potential bioweapon among health care professionals in Indore City. METHOD: The study design used was a cross sectional descriptive study was carried out between February-March 2015 during the outbreak of Swine Flu...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27338141/the-swine-flu-vaccine-public-attitudes-and-researcher-interpretations-a-systematic-review-of-qualitative-research
#20
Benedicte Carlsen, Claire Glenton
BACKGROUND: During pandemics, health authorities may be uncertain about the spread and severity of the disease and the effectiveness and safety of available interventions. This was the case during the swine flu (H1N1) pandemic of 2009-2010, and governments were forced to make decisions despite these uncertainties. While many countries chose to implement wide scale vaccination programmes, few accomplished their vaccination goals. Many research studies aiming to explore barriers and facilitators to vaccine uptake have been conducted in the aftermath of the pandemic, including several qualitative studies...
2016: BMC Health Services Research
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