keyword
MENU ▼
Read by QxMD icon Read
search

Cromolyn sodium

keyword
https://www.readbyqxmd.com/read/28733146/resveratrol-efficiently-improves-pulmonary-function-via-stabilizing-mast-cells-in-a-rat-intestinal-injury-model
#1
Xiaolei Huang, Weicheng Zhao, Dan Hu, Xue Han, Hanbin Wang, Jianyu Yang, Yang Xu, Yuantao Li, Weifeng Yao, Chaojin Chen
BACKGROUND: Intestinal ischemia/reperfusion (IIR) leads to acute lung injury (ALI) distally by aggravating pulmonary oxidative stress. Resveratrol is effective in attenuating ALI through its antioxidant capacity. This study aimed to determine the effects of resveratrol on IIR-induced ALI and to explore the role of mast cells (MCs) activation in a rat model of IIR. METHODS: Adult Sprague-Dawley rats were subjected to IIR by occluding the superior mesenteric artery for 60min followed by 4-hour reperfusion...
July 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/28694438/stress-induces-more-serious-barrier-dysfunction-in-follicle-associated-epithelium-than-villus-epithelium-involving-mast-cells-and-protease-activated-receptor-2
#2
Lei Zhang, Jun Song, Tao Bai, Wei Qian, Xiao-Hua Hou
Psychological stress has been associated with intestinal epithelial hyperpermeability, the basic process in various functional and organic bowel diseases. In the present study, we aimed to clarify the differences and underlining mechanisms in stress-induced barrier disruption in functionally and structurally distinct epitheliums, including the villus epithelium (VE) and follicle-associated epithelium (FAE), a specialized epithelium overlaid the domes of Peyer's lymphoid follicles. Employing an Ussing Chamber system, the epithelial permeability was assessed in rats following water avoidance stress (WAS) in vivo and in mucosa tissues exposed to corticotropin-releasing factor (CRF) ex vivo...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690169/unraveling-the-thermodynamics-binding-mechanism-and-conformational-changes-of-hsa-with-chromolyn-sodium-multispecroscopy-isothermal-titration-calorimetry-and-molecular-docking-studies
#3
Shama Yasmeen, Riyazuddeen, Faizan Abul Qais
Cromolyn sodium is an anti-allergic drug effective for treatment in asthma and allergic rhinitis. In this project, interaction of chromolyn sodium (CS) with human serum (HSA) has been investigated by various techniques such as UV-vis, fluorescence, circular dichorism (CD), fourier transform infrared (FT-IR) spectroscopy, isothermal titration calorimetric (ITC) and molecular docking. The fluorescence quenching results revealed that there was static quenching mechanism in the interactions of CS with HSA. The binding constant (Kb), enthalpy change (ΔH°), entropy change (ΔS°) and Gibbs free energy change (ΔG°) were calculated...
July 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28561222/cromolyn-sodium-attenuates-paraquat-induced-lung-injury-by-modulation-of-proinflammatory-cytokines
#4
Amir Larki Harchegani, Ali Asghar Hemmati, Amir Nili-Ahmadabadi, Borhan Darabi, Somayeh Shabib
The current study aimed to investigate the effects of Cromolyn Sodium (CS) on proinflammatory cytokines in Paraquat (PQ)-induced lung damage in rat. Animals were randomly divided into 5 groups. Group 1 and 2 received nebulized vehicle and CS (8 mg/kg) for 3 consecutive weeks, respectively. Group 3 was treated with single oral dose of PQ (40 mg/kg). Groups 4 and 5 were PQ groups which received nebulized CS (6 and 8 mg/kg/day, respectively) from 1 week before to 2 weeks after PQ administration. Finally, the animals were scarified and the changes of hydroxyproline (HP) and histology were evaluated in lung tissue...
May 2017: Drug Research
https://www.readbyqxmd.com/read/28556967/teriparatide-treatment-improves-bone-defect-healing-via-anabolic-effects-on-new-bone-formation-and-non-anabolic-effects-on-inhibition-of-mast-cells-in-a-murine-cranial-window-model
#5
Longze Zhang, Tao Wang, Martin Chang, Claire Kaiser, Jason D Kim, Tianyu Wu, Xiaoyi Cao, Xinping Zhang, Edward M Schwarz
Investigations of teriparatide (recombinant parathyroid hormone [rPTH]) as a potential treatment for critical defects have demonstrated the predicted anabolic effects on bone formation, and significant non-anabolic effects on healing via undefined mechanisms. Specifically, studies in murine models of structural allograft healing demonstrated that rPTH treatment increased angiogenesis (vessels <30 μm), and decreased arteriogenesis (>30 μm) and mast cell numbers, which lead to decreased fibrosis and accelerated healing...
May 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28471519/mast-cells-mediate-early-neutrophil-recruitment-and-exhibit-anti-inflammatory-properties-via-the-formyl-peptide-receptor-2-lipoxin-a4-receptor
#6
Ellen L Hughes, Felix Becker, Roderick J Flower, Julia C Buckingham, Felicity N E Gavins
BACKGROUND AND PURPOSE: In recent years, studies have focused on the resolution of inflammation, which can be achieved by endogenous anti-inflammatory agonists such as Annexin A1 (AnxA1). Here, we investigated the effects of mast cells (MCs) on early LPS-induced neutrophil recruitment and the involvement of the AnxA1-formyl peptide receptor 2/ALX (FPR2/ALX or lipoxin A4 receptor) pathway. EXPERIMENTAL APPROACH: Intravital microscopy (IVM) was used to visualize and quantify the effects of LPS (10 μg per mouse i...
July 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28222466/cromolyn-sodium-attenuates-paraquat-induced-lung-injury-by-modulation-of-proinflammatory-cytokines
#7
Amir Larki Harchegani, Ali Asghar Hemmati, Amir Nili-Ahmadabadi, Borhan Darabi, Somayeh Shabib
The current study aimed to investigate the effects of Cromolyn Sodium (CS) on proinflammatory cytokines in Paraquat (PQ)-induced lung damage in rat. Animals were randomly divided into 5 groups. Group 1 and 2 received nebulized vehicle and CS (8 mg/kg) for 3 consecutive weeks, respectively. Group 3 was treated with single oral dose of PQ (40 mg/kg). Groups 4 and 5 were PQ groups which received nebulized CS (6 and 8 mg/kg/day, respectively) from 1 week before to 2 weeks after PQ administration. Finally, the animals were scarified and the changes of hydroxyproline (HP) and histology were evaluated in lung tissue...
February 21, 2017: Drug Research
https://www.readbyqxmd.com/read/28114736/cromolyn-sodium-for-the-prevention-of-chronic-lung-disease-in-preterm-infants
#8
REVIEW
Geraldine Ng, Arne Ohlsson
BACKGROUND: This is an update of a review last published by Cochrane in June 2012 entitled "Cromolyn sodium for the prevention of chronic lung disease in preterm infants", which included two studies. This 2016 update identified no further studies.Chronic lung disease (CLD) frequently occurs in preterm infants and has a multifactorial aetiology including inflammation. Cromolyn sodium is a mast cell stabiliser that inhibits neutrophil activation and neutrophil chemotaxis and therefore may have a role in the prevention of CLD...
January 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27849111/pharmacological-interventions-for-pruritus-in-adult-palliative-care-patients
#9
REVIEW
Waldemar Siemens, Carola Xander, Joerg J Meerpohl, Sabine Buroh, Gerd Antes, Guido Schwarzer, Gerhild Becker
BACKGROUND: This is an update of the original Cochrane review published in 2013 (Issue 6). Pruritus occurs in patients with disparate underlying diseases and is caused by different pathologic mechanisms. In palliative care patients, pruritus is not the most prevalent but is one of the most puzzling symptoms. It can cause considerable discomfort and affects patients' quality of life. OBJECTIVES: To assess the effects of different pharmacological treatments for preventing or treating pruritus in adult palliative care patients...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27807556/ileal-pouch-biopsy-triggers-investigation-and-diagnosis-of-systemic-mastocytosis
#10
Abul Ala Syed Rifat Mannan, Bo Shen, Fred Hsieh, Deepa T Patil
We report a unique case of systemic mastocytosis (SM) diagnosed in an ileal pouch biopsy obtained from a 44-year-old woman with ulcerative colitis. She presented with intermittent abdominal pain and watery diarrhea that did not respond to antibiotic therapy. The pouch biopsy showed expansion of the lamina propria by aggregates of CD117 and CD25-positive abnormal mast cells. A subsequent bone marrow analysis showed an increase in abnormal mast cells. Based on World Health Organization criteria, she was diagnosed with SM and responded to cromolyn sodium therapy...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27678025/emerging-drugs-to-reduce-abnormal-%C3%AE-amyloid-protein-in-alzheimer-s-disease-patients
#11
REVIEW
Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Bruno P Imbimbo, Madia Lozupone, Antonio Leo, Rodolfo Sardone, Gaetano Gagliardi, Lucia Lofano, Bianca C Creanza, Paola Bisceglia, Antonio Daniele, Antonello Bellomo, Antonio Greco, Giancarlo Logroscino
Currently available drugs against Alzheimer's disease (AD) target cholinergic and glutamatergic neurotransmissions without affecting the underlying disease process. Putative disease-modifying drugs are in development and target β-amyloid (Aβ) peptide and tau protein, the principal neurophatological hallmarks of the disease. Areas covered: Phase III clinical studies of emerging anti-Aβ drugs for the treatment of AD were searched in US and EU clinical trial registries and in the medical literature until May 2016...
December 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27621136/simultaneous-determination-of-cromolyn-sodium-combined-dosage-forms-using-isocratic-hplc-method
#12
M E Fathy, S Abo El Abass Mohamed, H Elmansi, F Belal
A simple and selective reversed-phase high-performance liquid chromatography method was developed for the estimation of cromolyn sodium (CRM) with either oxymetazoline hydrochloride (OMZ) or xylometazoline hydrochloride (XMZ) in their binary mixtures. The method is based on the simultaneous separation of each drug in a reversed-phase Waters symmetry(®) C18 column (250 mm × 4.6 mm intradermally, 5-µm particle size) at 25°C. Elution was performed with a mobile phase consisting of methanol : 0.1 M phosphate buffer (60:40, v/v, pH 4...
January 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27605827/the-inhibitory-effect-of-cromolyn-sodium-and-ketotifen-on-toxoplasma-gondii-entrance-into-host-cells-in-vitro-and-in-vivo
#13
Fatemeh Rezaei, Mohammad Ali Ebrahimzadeh, Ahmad Daryani, Mehdi Sharif, Ehsan Ahmadpour, Shahabeddin Sarvi
Toxoplasma gondii is a protozoan with worldwide distribution and in spite of increasing information about its biology, treatment of toxoplasmosis is restricted to a few drugs and unfortunately using of each of drugs is associated with significant side effects in patients. This study was designed to evaluate the efficacy of cromolyn sodium and ketotifen as alternative drugs for the treatment of toxoplasmosis. In vitro; in case group, concentrations of 1, 5, 10 and 15 µg/ml of ketotifen and cromolyn sodium were added to RPMI medium containing peritoneal macrophages...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27548803/isolation-and-characterization-of-hepatic-mast-cells-from-cholestatic-rats
#14
Laura Hargrove, Allyson Graf-Eaton, Lindsey Kennedy, Jennifer Demieville, Jennifer Owens, Kyle Hodges, Brittany Ladd, Heather Francis
Mast cells (MCs) are immune cells that release histamine and other mediators. MC number increases after bile duct ligation (BDL) and blocking mast cell-derived histamine decreases biliary proliferation. We aimed to isolate and characterize MCs from cholestatic livers. Rats were subjected to BDL starting at 6 h and up to 14 days. MC infiltration was evaluated by toluidine blue. BDL rats were perfused using standard collagenase perfusion. Following enzymatic digestion, tissue was passed through a fine gauge needle...
November 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27351144/inhibition-of-mast-cell-secreted-histamine-decreases-biliary-proliferation-and-fibrosis-in-primary-sclerosing-cholangitis-mdr2-mice
#15
Hannah Jones, Laura Hargrove, Lindsey Kennedy, Fanyin Meng, Allyson Graf-Eaton, Jennifer Owens, Gianfranco Alpini, Christopher Johnson, Francesca Bernuzzi, Jennifer Demieville, Sharon DeMorrow, Pietro Invernizzi, Heather Francis
UNLABELLED: Hepatic fibrosis is marked by activation of hepatic stellate cells (HSCs). Cholestatic injury precedes liver fibrosis, and cholangiocytes interact with HSCs promoting fibrosis. Mast cells (MCs) infiltrate following liver injury and release histamine, increasing biliary proliferation. We evaluated if inhibition of MC-derived histamine decreases biliary proliferation and fibrosis. Wild-type and multidrug resistance 2 knockout mice (9-11 weeks) were treated with cromolyn sodium for 1 week to block MC-derived histamine...
October 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27304487/effect-of-intervention-in-mast-cell-function-before-reperfusion-on-renal-ischemia-reperfusion-injury-in-rats
#16
Fei Tong, Lei Luo, Daojun Liu
BACKGROUND/AIMS: Mast cells are sparsely distributed in the kidneys under normal conditions; however, the number of mast cells increases dramatically during renal ischemia/reperfusion injury (RI/RI). When mast cells are stimulated, numerous mediators are released, and under pathological conditions, they produce a wide range of biological effects. The aim of this study was to investigate the effect of intervention in mast cell function before reperfusion on RI/RI. METHODS: Sprague-Dawley (SD) rats (n=50) were randomized into five groups: sham group, ischemia/reperfusion (I/R) group, cromolyn sodium treatment group (CS+I/R group), ketotifen treatment group (K+I/Rgroup), and compound 48/80 treatment group (C+I/R group)...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27289241/the-hidden-side-of-disodium-cromolyn-from-mast-cell-stabilizer-to-an-angiogenic-factor-and-antitumor-agent
#17
Anca Maria Cimpean, Marius Raica
Scattered data suggested that disodium cromolyn, well known as a mast cell stabilizer shows some effects on tumor cells and tumor-associated newly formed vascular networks. Most of these studies used tumor cell lines assessed by in vitro studies. Nor disodium cromolyn effects on melanoma cell lines were studied yet, neither its influence on recruited tumor blood vessels or angiogenic growth factors expression. We designed here a study regarding disodium cromolyn effects on A375 melanoma tumor cells implanted on chick embryo chorioallantoic membrane (CAM) and on blood vessels recruited by the experimental melanoma in the absence of mast cells, knowing that within CAM, the existence of mast cells are not certified yet...
December 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27137797/corrigendum-to-identification-of-cromolyn-sodium-as-an-anti-fibrotic-agent-targeting-both-hepatocytes-and-hepatic-stellate-cells-pharmacol-res-102-2015-176-183
#18
Joon-Seok Choi, Jun Ki Kim, Yoon Jung Yang, Yeseul Kim, Pilhan Kim, Sang Gyu Park, Eun-Young Cho, Dae Ho Lee, Jin Woo Choi
No abstract text is available yet for this article.
April 29, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26981683/mast-cell-inhibition-attenuates-cardiac-remodeling-and-diastolic-dysfunction-in-middle-aged-ovariectomized-fischer-344-%C3%A3-brown-norway-rats
#19
Hao Wang, Jaqueline da Silva, Allan Alencar, Gisele Zapata-Sudo, Marina R Lin, Xuming Sun, Sarfaraz Ahmad, Carlos M Ferrario, Leanne Groban
The incidence of left ventricular diastolic dysfunction (LVDD) increases in women after menopause, yet the mechanisms are unclear. Because mast cells participate in the pathological processes of various cardiac diseases, we hypothesized that mast cell inhibition would protect against estrogen loss-induced LVDD. The mast cell stabilizer, cromolyn sodium (30 mg·kg·d), or vehicle was administered subcutaneously by osmotic minipump to ovariectomized (OVX) female Fischer 344 × Brown Norway (F344BN) rats starting at 4 weeks after surgery...
July 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/26885889/highly-water-soluble-mast-cell-stabiliser-encapsulated-solid-lipid-nanoparticles-with-enhanced-oral-bioavailability
#20
Ravi R Patel, Sundeep Chaurasia, Gayasuddin Khan, Pramila Chaubey, Nagendra Kumar, Brahmeshwar Mishra
Cromolyn sodium (CS), a mast cell stabiliser, is widely employed for the prevention and treatment of allergic conditions. However, high hydrophilicity and poor oral permeability hinder its oral clinical translation. Here, solid lipid nanoparticles (SLNs) have been developed for the purpose of oral bioavailability enhancement. The CS-SLNs were engineered by double emulsification method (W1/O/W2) and optimised by using Box-Behnken experimental design. The surface and solid-state characterisations revealed the presence of CS in an amorphous form without any interactions inside the spherical-shaped SLNs...
May 2016: Journal of Microencapsulation
keyword
keyword
86522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"