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JOURNAL ARTICLE
Hiroto Takiguchi, Kazuo Koyanagi, Soji Ozawa, Tsuyoshi Oguma, Koichiro Asano
BACKGROUD: Oesophageal cancer patients are prone to early- and late-onset pneumonia after oesophagectomy. We aimed to investigate the incidence rate and impact on the long-term prognosis of late-onset pneumonia in oesophageal cancer survivors who survived for at least one year after oesophagectomy without cancer recurrence. METHODS: We retrospectively reviewed 233 patients with thoracic oesophageal cancer who underwent oesophagectomy with gastric conduit reconstruction between September 2009 and June 2019 at a tertiary referral hospital in Japan...
April 19, 2024: Respiratory Investigation
#22
JOURNAL ARTICLE
Hannah C Coulson, Miriam Brown, Kyle Burke, Emma Griffith, Victoria Shadiack, Harold R Garner, Jaime A Foushee
CONTEXT: Clinical clerkships provide osteopathic medical students the opportunity to participate in the diagnosis and treatment of commonly encountered medical conditions. Appropriate management of these conditions may include pharmacotherapy and/or nonpharmacologic interventions, such as osteopathic manipulative treatment (OMT). Opportunities may exist to expand the utilization of OMT in the management of common conditions, particularly for geriatric patients, who are at increased risk for adverse outcomes from pharmacologic treatments...
April 22, 2024: Journal of osteopathic medicine
#23
JOURNAL ARTICLE
Mia Berglund, Susanne Andersson, Anna Kjellsdotter
AIM: To describe patients' with chronic obstructive pulmonary disease (COPD) experiences of group-based self-management education with a digital website. DESIGN: A qualitative approach with a phenomenologicalmethod. Patients participating in an earlier study, with self-experience of COPD as a special competence, were involved as research partners at the design of this study. METHODS: Eleven individual and two group interviews with five participants in each group were conducted...
April 2024: Nursing Open
#24
JOURNAL ARTICLE
Liang Zhou, Lei Fang, Michael Roth, Eleni Papakonstantinou, Michael Tamm, Daiana Stolz
PURPOSE: The response to glucocorticoids is hampered in many COPD patients by a yet unknown mechanism. Earlier we reported that short-term heat exposure of primary human bronchial epithelial cells (BEC) and airway smooth muscle cells (ASMC) of asthma patients increased the expression and secretion of extracellular heat shock proteins (eHSPs) resulting in increased expression of glucocorticoid receptor (GR) in BEC and inhibition of ASMC remodeling. The aim of the present study was to assess if the same mechanism is also present in primary airway wall cells of COPD patients...
April 19, 2024: Lung
#25
JOURNAL ARTICLE
Maggie Tabberer, Nicola Williamson, Sophi Tatlock, Adam Gater, Rebecca Grimes, Chika Akinseye, David Neil, Aoife Mahon-Smith, Linda Nelsen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and muscle weakness can cause impaired physical function, significantly impacting patients' health-related quality of life (HRQoL). Loss of muscle strength is usually assessed through clinical and performance outcome (PerfO) assessments, which consists of tasks performed in a standardized manner, providing evidence of a patient's functional ability. However, evidence documenting the patient experience of COPD and muscle weakness is limited...
April 20, 2024: Journal of Patient-Reported Outcomes
#26
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl A Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Joshua D Hoffman, John E Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nicholas Locantore, Jian'an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David J Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul R H J Timmers, Maarten Van den Berge, John C Whittaker, Prescott G Woodruff, Laura M Yerges-Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
No abstract text is available yet for this article.
April 19, 2024: Nature Genetics
#27
JOURNAL ARTICLE
Virginia Mara Reis Gomes, Magda Carvalho Pires, Polianna Delfino Pereira, Alexandre Vargas Schwarzbold, Angélica Gomides Dos Reis Gomes, Bruno Porto Pessoa, Christiane Correa Rodrigues Cimini, Danyelle Romana Alves Rios, Fernando Anschau, Francine Janaína Magalhães Nascimento, Genna Maira Santos Grizende, Giovanna Grunewald Vietta, Joanna d'Arc Lyra Batista, Karen Brasil Ruschel, Marcelo Carneiro, Marco Aurélio Reis, Maria Aparecida Camargos Bicalho, Paula Fonseca Porto, Priscilla Pereira Dos Reis, Silvia Ferreira Araújo, Vandack Nobre, Milena Soriano Marcolino
PURPOSE: To develop a mortality risk score for COVID-19 patients admitted to intensive care units (ICU), and to compare it with other existing scores. MATERIALS AND METHODS: It is a retrospective observational study, including consecutive adult patients with laboratory-confirmed COVID-19 admitted to ICUs of 18 hospitals from nine Brazilian cities, from 09/2021 to 07/2022. Potential predictors were selected based on the literature review. Generalized Additive Models were used to examine outcomes and predictors...
April 17, 2024: Respiratory Medicine
#28
JOURNAL ARTICLE
Xiang Xie, Juan Zheng, Zhen Li, Jun Qi, Lili Li, Lindong Yuan, Tingting Jiang, Ziyun Yang, Shan Qin, Xiufen Tian, Yan Wang, Peige Zhao
Currently, few studies have demonstrated the relationship between total serum IgE (T-IgE) and acute exacerbation chronic obstructive pulmonary disease (AECOPD). In this study, T-IgE in AECOPD patients were investigated and jointly analyzed with the clinical characteristics. AECOPD patients hospitalized from July 2018 to July 2019 were included in this study. In this patient cohort, clinical information was investigated. Routine blood tests, C-reactive protein and T-IgE levels of patients were determined along with blood gas analysis...
April 19, 2024: Medicine (Baltimore)
#29
JOURNAL ARTICLE
Hui Wang, Hao Zhang, Wei Yuan
OBJECTIVE: This study evaluates the role of macrophage intracellular tyrosine phosphatase PTP1B in slowing the progression of Chronic Obstructive Pulmonary Disease (COPD) through the inhibition of the SHP-2/Src/ERK1/2/NLRP3 signaling pathway. METHODS: We administered PTP1B non-targeting control (NC) and PTP1B overexpression (OE) lentiviruses to mice. Post-infection, lung tissues underwent Hematoxylin and Eosin (HE) staining and immunofluorescence analysis to detect PTP1B, SHP2, Src, and FAK protein levels...
April 18, 2024: Alternative Therapies in Health and Medicine
#30
JOURNAL ARTICLE
Haidong Ding, Rina Wu
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is characterized by airflow limitation and inflammation resulting from genetic and environmental factors, notably cigarette smoke. Pyroptosis, a cell death process, is implicated in COPD, but its mechanisms are unclear. SHP2, a phosphatase, modulates inflammatory pathways, suggesting a role in COPD pathogenesis and potential therapeutic avenues. OBJECTIVE: This study investigates the mechanism by which SHP2 regulates cell pyroptosis in bronchial epithelial cells in COPD patients...
April 18, 2024: Alternative Therapies in Health and Medicine
#31
JOURNAL ARTICLE
F Bozkuş, A Samur, O Yazıcı
OBJECTIVE: This study was designed to investigate the relationship between eosinophil count and cardiovascular disease (CVD) in subjects with chronic obstructive pulmonary disease (COPD) and the correlation between eosinophil count and the risk of exacerbations in COPD. PATIENTS AND METHODS: The study included 405 patients who met the study inclusion criteria. Of the participants, 100 (25%) were classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) A, 105 (26%) as GOLD B, and 200 (49%) as GOLD E...
April 2024: European Review for Medical and Pharmacological Sciences
#32
JOURNAL ARTICLE
Ying Hu, Ye Wang, Zhuohui Zhao, Bin Zhao
Nitrogen dioxide (NO2 ) is a prevalent air pollutant in urban areas, originating from outdoor sources, household gas consumption, and secondhand smoke. The limited evaluation of the disease burden attributable to NO2 , encompassing different health effects and contributions from various sources, impedes our understanding from a public health perspective. Based on modeled NO2 exposure concentrations, their exposure-response relationships with lung cancer, chronic obstructive pulmonary disease, and diabetes mellitus, and baseline disability-adjusted life years (DALYs), we estimated that 1,675 (655-2,624) thousand DALYs were attributable to NO2 in urban China in 2019 [138 (54-216) billion Chinese yuan (CNY) economic losses]...
June 2024: Eco Environ Health
#33
JOURNAL ARTICLE
Chung-Ho E Lau, Maria Manou, Georgios Markozannes, Mika Ala-Korpela, Yoav Ben-Shlomo, Nish Chaturvedi, Jorgen Engmann, Aleksandra Gentry-Maharaj, Karl-Heinz Herzig, Aroon Hingorani, Marjo-Riitta Järvelin, Mika Kähönen, Mika Kivimäki, Terho Lehtimäki, Saara Marttila, Usha Menon, Patricia B Munroe, Saranya Palaniswamy, Rui Providencia, Olli Raitakari, Amand Floriaan Schmidt, Sylvain Sebert, Andrew Wong, Paolo Vineis, Ioanna Tzoulaki, Oliver Robinson
Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological age (CA), mortality, and age-related disease. Ninety-eight metabolic variables were measured in blood from nine UK and Finnish cohort studies (N ≈31,000 individuals, age range 24-86 years). We used nonlinear and penalized regression to model CA and time to all-cause mortality...
April 18, 2024: Aging Cell
#34
JOURNAL ARTICLE
Zecheng Zhu, Shunjin Zhao, Jiahui Li, Yuting Wang, Luopiao Xu, Yubing Jia, Zihan Li, Wenyuan Li, Gang Chen, Xifeng Wu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it is identified early and managed effectively. This study aims to develop an advanced COPD diagnostic model by integrating deep learning and radiomics features. METHODS: We utilized a dataset comprising CT images from 2,983 participants, of which 2,317 participants also provided epidemiological data through questionnaires. Deep learning features were extracted using a Variational Autoencoder, and radiomics features were obtained using the PyRadiomics package...
April 18, 2024: Respiratory Research
#35
JOURNAL ARTICLE
Yangli Liu, Fengjia Chen, Zhimin Zeng, Chengcheng Lei, Dubo Chen, Xiaoyu Zhang
BACKGROUND AND OBJECTIVE: Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a novel biomarker for identifying the increased risk of adverse cardiovascular events. This study aims to investigate the association of NP with endothelial dysfunction and impaired lung function in COPD, asthma, and ACO patients...
April 18, 2024: Respiratory Research
#36
JOURNAL ARTICLE
Julia Hippisley-Cox, Carol A C Coupland, Mona Bafadhel, Richard E K Russell, Aziz Sheikh, Peter Brindle, Keith M Channon
QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which we have named QR4, that incorporates novel risk factors to estimate 10-year CVD risk separately for men and women. Health data from 9.98 million and 6.79 million adults from the United Kingdom were used for derivation and validation of the algorithm, respectively. Cause-specific Cox models were used to develop models to predict CVD risk, and the performance of QR4 was compared with version 3 of QRISK, Systematic Coronary Risk Evaluation 2 (SCORE2) and atherosclerotic cardiovascular disease (ASCVD) risk scores...
April 18, 2024: Nature Medicine
#37
JOURNAL ARTICLE
Gwon-Min Kim, Seunghwan Song, Do Young Kim, Soo Han Kim, Chung Won Lee, Miju Bae, Jong Won Kim, Up Huh
We analyzed chemoport insertion procedures to evaluate infectious morbidity and factors causing infection. This single-center retrospective study included 1690 cases of chemoport implantation between January 2017 and December 2020. Overall, chemoports were inserted in 1582 patients. The average duration of chemoport use was 481 days (range 1-1794, median 309). Infections occurred in 80 cases (4.7%), with 0.098 per 1000 catheter-days. Among the 80 cases in which chemoports were removed because of suspected infection, bacteria were identified in 48 (60%)...
April 18, 2024: Scientific Reports
#38
JOURNAL ARTICLE
Yun Soo Hong, Hye Yun Park, Seungho Ryu, Sun Hye Shin, Di Zhao, Dave Singh, Eliseo Guallar, Juhee Cho, Yoosoo Chang, Seong Yong Lim
BACKGROUND: Accelerated lung function decline is characteristic of chronic obstructive pulmonary disease (COPD). However, the association between blood eosinophil counts and lung function decline, accounting for current smoking status, in young individuals without prevalent lung disease is not fully understood. METHODS: This is a cohort study of 629 784 Korean adults without COPD or a history of asthma at baseline who participated in health screening examinations including spirometry and differential white blood cell counts...
April 18, 2024: European Respiratory Journal
#39
JOURNAL ARTICLE
Jiangdong Liu, Mengmeng Li, Zhou Yang, Di Liu, Ting Xiao, Jian Cheng, Hong Su, Chun-Quan Ou, Jun Yang
BACKGROUND: Previous studies on the effect of global warming on the global burden of disease have mainly focussed on the impact of high temperatures, thereby providing limited evidence of the effect of lower temperatures. METHODS: We adopted a three-stage analysis approach using data from the Global Burden of Disease 2019 study. First, we explored the global burden of disease attributable to low temperatures, examining variations by gender, age, cause, region, and country...
April 19, 2024: Journal of Global Health
#40
JOURNAL ARTICLE
Zhenjie Yu, Jingchun He, Yawen Chen, Ziqi Zhou, Lan Wang
Sarcopenia prevalence and its risk factors in chronic obstructive pulmonary disease (COPD) vary partly due to definition criteria. This systematic review aimed to identify the prevalence and risk factors of sarcopenia in COPD patients. This review was registered in PROSPERO (CRD42022310750). Nine electronic databases were searched from inception to September 1st, 2022, and studies related to sarcopenia and COPD were identified. Study quality was assessed using a validated scale matched to study designs, and a meta-analysis was performed to evaluate sarcopenia prevalence...
2024: PloS One
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