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https://www.readbyqxmd.com/read/28549708/chronic-obstructive-pulmonary-disease-in-post-acute-long-term-care-settings-seizing-opportunities-to-individualize-treatment-and-device-selection
#1
Meenakshi Patel, Karl Steinberg, Manuel Suarez-Barcelo, Dana Saffel, Rick Foley, Chad Worz
INTRODUCTION: The burden of chronic obstructive pulmonary disease (COPD) in post-acute/long-term care (PA/LTC) settings is high, and many patients do not receive guideline-recommended care. METHODS: An interprofessional expert panel of PA/LTC professionals convened to discuss the unmet medical needs in patients with COPD in PA/LTC settings, and to make recommendations for the assessment of COPD patients to individualize the selection of maintenance treatment. RESULTS: Unmet needs observed in patients with COPD are described in addition to new tools for assessing individual patient abilities and appropriate device selection for maintenance treatment...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28548632/diagnostic-and-prognostic-value-of-inflammatory-parameters-including-neopterin-in-the-setting-of-pneumonia-copd-and-acute-exacerbations
#2
Alex Pizzini, Fabian Lunger, Amra Sahanic, Nada Nemati, Dietmar Fuchs, Günter Weiss, Katharina Kurz, Rosa Bellmann-Weiler
Acute exacerbations and community-acquired pneumonia (CAP) are severe complications in patients with chronic obstructive pulmonary disease (COPD). In this study, we analyzed inflammatory parameters in serum including C-reactive protein (CRP), procalcitonin (PCT), and serum neopterin (NPT) to determine their potential to differentiate between patients with CAP+COPD and with acute exacerbations of COPD (AECOPD) without pneumonia. 102 (39 women and 63 men) patients were included in this retrospective study, of whom 48 presented with CAP without underlying COPD, 20 with CAP+COPD and 34 with AECOPD...
June 2017: COPD
https://www.readbyqxmd.com/read/28548631/effectiveness-of-a-respiratory-day-hospital-program-to-reduce-admissions-for-exacerbation-in-patients-with-severe-copd-a-prospective-multicenter-study
#3
Daniel Huertas, Concepción Montón, Alicia Marín, Ingrid Solanes, Marta López-Sánchez, Xavier Pomares, Mariana Muñoz-Esquerre, Jordi Dorca, Salud Santos
The respiratory Day Hospital (DH) is a care facility currently operating at various healthcare institutions. It monitors patients with severe chronic obstructive pulmonary disease (COPD) presenting repeated exacerbations with at least two hospital admissions per year. The main aim of the study was to evaluate the effectiveness of the DH program for controlling admissions for COPD exacerbations in this cohort of patients, and to identify clinical factors associated with hospitalizations and mortality. An observational prospective multicenter study was carried out at three hospitals...
June 2017: COPD
https://www.readbyqxmd.com/read/28548545/mild-chronic-obstructive-pulmonary-disease-why-spirometry-is-not-sufficient
#4
Amany F Elbehairy, Grace Parraga, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
Chronic obstructive pulmonary disease (COPD) - an inflammatory disease of the airways, alveoli and lung microvasculature - is a leading cause of death worldwide. Smokers with milder airway obstruction constitute the majority of patients with this disease. Many studies have shown increased morbidity, activity-related dyspnea, exercise intolerance and mortality in such patients, compared with age-matched healthy populations. Clinical evaluation of symptomatic smokers with ostensibly mild airway obstruction poses a challenge in clinical practice as spirometry can obscure extensive heterogeneous pathophysiological impairment...
May 26, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28547823/asthma-other-atopic-conditions-and-risk-of-infections-in-105-519-general-population-never-and-ever-smokers
#5
Jens Helby, Børge Grønne Nordestgaard, Thomas Benfield, Stig Egil Bojesen
BACKGROUND: Individuals with atopic conditions may have increased susceptibility to infections outside the organs directly affected by their atopic condition. OBJECTIVE: We tested the hypothesis that atopic conditions overall, and stratified by smoking history, are associated with increased risk of hospitalization for infections. METHODS: We collected information on smoking history and self-reported atopic conditions from 105,519 individuals from the general population and followed them for up to 23 years for infectious disease hospitalizations and deaths...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28547129/quantitative-analysis-of-dynamic-18-f-fdg-pet-ct-for-measurement-of-lung-inflammation
#6
Christopher Coello, Marie Fisk, Divya Mohan, Frederick J Wilson, Andrew P Brown, Michael I Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S Murphy, Joseph Cheriyan, Roger N Gunn
BACKGROUND: An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce a fully quantitative analysis method and compare this with previously published studies based on the Patlak approach using a dataset comprising (18)F-FDG PET scans from COPD subjects with elevated circulating inflammatory markers (fibrinogen) and matched healthy volunteers (HV)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28546747/the-direct-and-indirect-costs-of-managing-chronic-obstructive-pulmonary-disease-in-greece
#7
Kyriakos Souliotis, Hara Kousoulakou, Georgios Hillas, Nikos Tzanakis, Michalis Toumbis, Theodoros Vassilakopoulos
OBJECTIVE: COPD is associated with significant economic burden. The objective of this study was to explore the direct and indirect costs associated with COPD and identify the key cost drivers of disease management in Greece. METHODS: A Delphi panel of Greek pulmonologists was conducted, which aimed at eliciting local COPD treatment patterns and resource use. Resource use was translated into costs using official health insurance tariffs and Diagnosis-Related Groups (DRGs)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28546746/genetic-polymorphism-and-chronic-obstructive-pulmonary-disease
#8
REVIEW
Cunhua Yuan, De Chang, Guangming Lu, Xiaowei Deng
Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its morbidity and mortality are increasing. There are many studies that have tried to explain the pathogenesis of COPD from genetic susceptibility, to identify the susceptibility of COPD factors, which play a role in early prevention, early detection and the early treatment. However, it is well known that COPD is an inflammatory disease characterized by incomplete reversible airflow limitation in which genes interact with the environment...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28546484/complete-genome-sequence-of-moraxella-catarrhalis-strain-ccri-195me-isolated-from-the-middle-ear
#9
Aimee Tan, Luke V Blakeway, Lauren O Bakaletz, Matthew Boitano, Tyson A Clark, Jonas Korlach, Michael P Jennings, Ian R Peak, Kate L Seib
Moraxella catarrhalis is an important bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we report the complete genome sequence of M. catarrhalis strain CCRI-195ME, which contains the phase-variable epigenetic regulator ModM3.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28546320/a-cohort-mortality-study-of-lead-exposed-workers-in-the-usa-finland-and-the-uk
#10
Kyle Steenland, Vaughn Barry, Ahti Anttila, Markku Sallmén, Damien McElvenny, A C Todd, Kurt Straif
OBJECTIVES: To investigate further whether inorganic lead is a carcinogen among adults, or associated with increased blood pressure and kidney damage, via a large mortality study. METHODS: We conducted internal analyses via Cox regression of mortality in three cohorts of lead-exposed workers with blood lead (BL) data (USA, Finland, UK), including over 88 000 workers and over 14 000 deaths. Our exposure metric was maximum BL. We also conducted external analyses using country-specific background rates...
May 25, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28546273/mir-146a-5p-plays-an-essential-role-in-the-aberrant-epithelial-fibroblast-cross-talk-in-copd
#11
Emmanuel T Osei, Laura Florez-Sampedro, Hataitip Tasena, Alen Faiz, Jacobien A Noordhoek, Wim Timens, Dirkje S Postma, Tillie L Hackett, Irene H Heijink, Corry-Anke Brandsma
We previously reported that epithelial-derived interleukin (IL)-1α drives fibroblast-derived inflammation in the lung epithelial-mesenchymal trophic unit. Since miR-146a-5p has been shown to negatively regulate IL-1 signalling, we investigated the role of miR-146a-5p in the regulation of IL-1α-driven inflammation in chronic obstructive pulmonary disease (COPD).Human bronchial epithelial (16HBE14o-) cells were co-cultured with control and COPD-derived primary human lung fibroblasts (PHLFs), and miR-146a-5p expression was assessed with and without IL-1α neutralising antibody...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28546268/home-based-maintenance-tele-rehabilitation-reduces-the-risk-for-acute-exacerbations-of-copd-hospitalisations-and-emergency-department-visits
#12
Maroula Vasilopoulou, Andriana I Papaioannou, Georgios Kaltsakas, Zafeiris Louvaris, Nikolaos Chynkiamis, Stavroula Spetsioti, Eleni Kortianou, Sofia Antiopi Genimata, Anastasios Palamidas, Konstantinos Kostikas, Nikolaos G Koulouris, Ioannis Vogiatzis
Pulmonary rehabilitation (PR) remains grossly underutilised by suitable patients worldwide. We investigated whether home-based maintenance tele-rehabilitation will be as effective as hospital-based maintenance rehabilitation and superior to usual care in reducing the risk for acute chronic obstructive pulmonary disease (COPD) exacerbations, hospitalisations and emergency department (ED) visits.Following completion of an initial 2-month PR programme this prospective, randomised controlled trial (between December 2013 and July 2015) compared 12 months of home-based maintenance tele-rehabilitation (n=47) with 12 months of hospital-based, outpatient, maintenance rehabilitation (n=50) and also to 12 months of usual care treatment (n=50) without initial PR...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28546041/10-years-single-centre-results-of-abdominal-aortic-aneurysm-treatment-endovascular-vs-open-repair
#13
Payman Majd, Wael Ahmad, Ingrid Becker, Jan Sigge Brunkwall
OBJECTIVES: The purpose of the present study was to compare the long-term survival in matched cohorts of patients with infrarenal abdominal aortic aneurysm (AAA) undergoing an elective open repair (OR) or an endovascular aneurysm repair (EVAR). MATERIALS AND METHODS: Patients with a primary elective repair of an infrarenal aortic aneurysm between 1998 and 2006 were identified in a retrospective review of our single centre database. EVAR and OR patients were matched with respect to age, gender, renal disease, tobacco use, hypertension, chronic obstructive pulmonary disease and coronary artery disease...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28545799/the-relationship-of-the-perceived-impact-of-the-current-greek-recession-with-increased-suicide-risk-is-moderated-by-mental-illness-in-patients-with-long-term-conditions
#14
Elisavet Ntountoulaki, Vassiliki Paika, Dimitra Papaioannou, Elspeth Guthrie, Konstantinos Kotsis, Konstantinos N Fountoulakis, Andre F Carvalho, Thomas Hyphantis
OBJECTIVE: Adverse life events may contribute to the emergence of suicidality. We aimed to test the relationship between the impact of the Greek recession and suicidal risk in people with long-term conditions (LTCs) and to determine whether this relationship is moderated by the presence of a mental disorder. METHODS: Suicidal risk (RASS) and crisis parameters were assessed in a cross-sectional survey including 376 patients with LTCs (type-II diabetes mellitus, rheumatological disorders and chronic obstructive pulmonary disease) attending the Emergency Department or specialty clinics...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28545542/recognition-and-treatment-of-sleep-disordered-breathing-an-important-component-of-chronic-disease-management
#15
REVIEW
Peter C Farrell, Glenn Richards
Sleep-disordered breathing (SDB) is a highly prevalent condition, and is associated with many debilitating chronic diseases. The role of untreated obstructive sleep apnea (OSA) in arterial hypertension has been recognized in international guidelines. Treatment with continuous positive airway pressure (CPAP) is associated with clinically-relevant reductions in blood pressure. In heart failure (HF), SDB is associated with worse prognosis and increased mortality. Major HF guidelines recommend that patients should be treated for sleep apnea to improve their HF status...
May 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28545096/vascular-disease-in-copd-systemic-and-pulmonary-expression-of-parc-pulmonary-and-activation-regulated-chemokine
#16
Mariana Muñoz-Esquerre, Elisabet Aliagas, Marta López-Sánchez, Ignacio Escobar, Daniel Huertas, Rosa Penín, Jordi Dorca, Salud Santos
INTRODUCTION: The role of Pulmonary and Activation-Regulated Chemokine (PARC) in the physiopathology of Chronic Obstructive Pulmonary Disease (COPD) is not fully understood. The aim of the present study is to analyze the expression of PARC in lung tissue and its relationship with the vascular remodeling of the systemic and pulmonary arteries of COPD subjects. METHODS: To achieve this objective, protein and gene expression experiments, together with ELISA assays, were performed on the lung tissue, intercostal arteries and serum samples from COPD patients, non-obstructed smokers (NOS) and never-smokers (NS)...
2017: PloS One
https://www.readbyqxmd.com/read/28544519/the-effect-of-helium-oxygen-assisted-mechanical-ventilation-on-chronic-obstructive-pulmonary-disease-exacerbation-a-systemic-review-and-meta-analysis
#17
Xu Wu, Chuan Shao, Liang Zhang, Jinjing Tu, Hui Xu, Zhihui Lin, Shuguang Xu, Biyun Yu, Yaodong Tang, Shanqun Li
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is often accompanied by acute exacerbations. Patients of COPD exacerbation suffering from respiratory failure often need the support of mechanical ventilation. Helium-oxygen can be used to reduce airway resistance during mechanical ventilation. The aim of this study is to evaluate the effect of helium-oxygen-assisted mechanical ventilation on COPD exacerbation through a meta-analysis. METHODS: A comprehensive literature search through databases of Pub Med (1966∼2016), Ovid MEDLINE (1965∼2016), Cochrane EBM (1991∼2016), EMBASE (1974∼2016) and Ovid MEDLINE was performed to identify associated studies...
May 24, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28544504/the-impact-of-telephone-delivered-cognitive-behaviour-therapy-and-befriending-on-mood-disorders-in-people-with-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#18
Colleen Doyle, Sunil Bhar, Marcia Fearn, David Ames, Debra Osborne, Emily You, Alex Gorelik, David Dunt
OBJECTIVES: The main objectives of this pragmatic randomized controlled trial were to investigate the impact of cognitive behaviour therapy (CBT) and an active social control (befriending) on depression and anxiety symptoms in people with chronic obstructive pulmonary disease (COPD). METHODS: Eligible participants were randomly allocated to receive eight weekly telephone interventions of CBT (n = 54) or befriending (n = 56). Repeated-measures ANOVA was used to assess changes in scores and Cohen's d was used to assess effect sizes...
May 22, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28544468/analysis-of-the-patients-with-simultaneous-bilateral-spontaneous-pneumothorax
#19
Tevfik Ilker Akcam, Onder Kavurmaci, Ayse Gul Ergonul, Sercan Aydin, Kutsal Turhan, Alpaslan Cakan, Ufuk Cagirici
BACKGROUND: Simultaneous bilateral spontaneous pneumothorax (SBSP) is an uncommon condition with limited data on its incidence in the literature. In this study, we aimed to describe the bilaterality in both primary and secondary spontaneous pneumothorax cases, and the clinical approach in simultaneous disease and prognosis of these patients. METHODS: A total of 16 patients who were followed with the diagnosis of bilateral spontaneous pneumothorax between January 2005 and January 2017 were retrospectively analyzed...
May 20, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28544091/a-new-predictive-model-for-acute-gastrointestinal-bleeding-in-patients-taking-oral-anticoagulants-a-cohort-study
#20
Akira Shimomura, Naoyoshi Nagata, Takuro Shimbo, Toshiyuki Sakurai, Shiori Moriyasu, Hidetaka Okubo, Kazuhiro Watanabe, Chizu Yokoi, Junichi Akiyama, Naomi Uemura
BACKGROUND: We developed a predictive model of long-term gastrointestinal (GI) bleeding risk in patients receiving oral anticoagulants and compared it with the HAS-BLED score. METHODS: We periodically followed a cohort of 508 patients taking oral anticoagulants (66 direct oral anticoagulants users and 442 warfarin users). Absence of GI bleeding at an initial examination, and any subsequent GI bleeding, were confirmed endoscopically. The bleeding model was developed by multivariate survival analysis and evaluated by Harrell's c-index...
May 19, 2017: Journal of Gastroenterology and Hepatology
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