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https://www.readbyqxmd.com/read/29334725/physical-activity-in-chronic-obstructive-pulmonary-disease-clinical-impact-and-risk-factors
#1
Kyeong-Cheol Shin
No abstract text is available yet for this article.
January 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334676/statins-in-the-treatment-of-copd-and-asthma-where-do-we-stand
#2
REVIEW
Jennifer Y So, Santosh Dhungana, Joanna J Beros, Gerard J Criner
Asthma and chronic obstructive pulmonary disease (COPD) are the two most prevalent obstructive lung diseases that account for tremendous morbidity and mortality throughout the world. These diseases have strong inflammatory components, with multiple prior studies showing elevated levels of various inflammatory markers and cells in those with COPD and asthma. Therefore, efforts to target inflammation in management of these diseases are of great interest. Statins, which define a class of drugs that are HMG-CoA inhibitors, are used to decrease cholesterol levels and have also been described to have many pleotropic effects that include anti-inflammatory and anti-oxidative properties...
January 12, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29333619/surrogate-scale-for-evaluating-respiratory-function-based-on-complete-blood-count-parameters
#3
Yang Guang, Zhou Jie, Dong Feng, Liu Hui
BACKGROUND: In this study, we aimed to identify a simple method for evaluating respiratory function using complete blood count parameters. METHODS: The complete blood count parameters, including red blood cell (RBC) count, hemoglobin (Hb) level, lymphocyte (Lym) and platelet (Plt) count, and partial pressure of oxygen (PO2 ) level, were measured using automated analyzers in patients with chronic obstructive pulmonary disease (COPD), aged subjects, and young subjects (control group)...
January 15, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29332840/examining-patterns-of-multimorbidity-polypharmacy-and-risk-of-adverse-drug-reactions-in-chronic-obstructive-pulmonary-disease-a-cross-sectional-uk-biobank-study
#4
Peter Hanlon, Barbara I Nicholl, Bhautesh Dinesh Jani, Ross McQueenie, Duncan Lee, Katie I Gallacher, Frances S Mair
OBJECTIVE: This study aims: (1) to describe the pattern and extent of multimorbidity and polypharmacy in UK Biobank participants with chronic obstructive pulmonary disease (COPD) and (2) to identify which comorbidities are associated with increased risk of adverse drug reactions (ADRs) resulting from polypharmacy. DESIGN: Cross-sectional. SETTING: Community cohort. PARTICIPANTS: UK Biobank participants comparing self-reported COPD (n=8317) with no COPD (n=494 323)...
January 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29332678/relationship-of-sleep-pattern-and-snoring-with-chronic-disease-findings-from-a-nationwide-population-based-survey
#5
Fakir Md Yunus, Safayet Khan, Dipak K Mitra, Sabuj Kanti Mistry, Kaosar Afsana, Mahfuzar Rahman
OBJECTIVES: To investigate the association of total sleep time and presence or absence of snoring with chronic disease among the Bangladeshi adult population. DESIGN: Cross-sectional survey. SETTING: Urban and rural Bangladesh. PARTICIPANTS: A total of 12,338 men and women aged ≥35 years. MEASUREMENTS: Total sleep time was considered as the total hours of sleep in 24 hours. Furthermore, sleep time was categorized into <7, 7-9, and >9 hours according to National Sleep Foundation (2015) guidelines...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29332652/initial-airflow-obstruction-in-new-cases-of-pulmonary-tuberculosis-complication-comorbidity-or-missed
#6
Andrii Dudnyk, Svitlana Blyzniuk, Oleksandr Pavel'chuk, Olena Zakharchenko, Dmytro Butov, Sergiі Zaіkov
Tuberculosis (TB) may have a similar spirometry findings as a chronic obstructive pulmonary disease but the prevalence of TB-induced airflow obstruction (AO) is still unknown. OBJECTIVES: To measure frequency of AO in new TB cases at the beginning of treatment and to evaluate factors associated with obstructive abnormalities following TB diagnosis. MATERIALS AND METHODS: 317 patients that have no history of prior AO were recruited into the study with a median age of 39...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29332624/-not-all-exacerbations-of-chronic-obstructive-pulmonary-disease-should-be-treated-with-antibiotics
#7
Stefan Kern Nielsen, Peter Lange
This review gives an update on antibiotic treatment of exacerbation of chronic obstructive pulmonary disease (COPD). Patients who do not need hospital admission and do not present with purulent sputum nor increased levels of C reactive protein/procalcitonin have no beneficial effect of antibiotic treatment. Those with severe COPD and increased sputum purulence should be treated with antibiotics, and first-line treatment should be amoxicillin, which is effective against the most common types of bacteria in COPD exacerbation...
April 10, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29332320/the-role-of-tiotropium-olodaterol-dual-bronchodilator-therapy-in-the-management-of-chronic-obstructive-pulmonary-disease
#8
REVIEW
David M G Halpin
Bronchodilator therapy is central to the management of chronic obstructive pulmonary disease and are recommended as the preferred treatment by the Global Obstructive Lung Disease Initiative (GOLD). Long acting anti-muscarinics (LAMA) and long acting β₂ agonists (LABA) are both more effective than regular short-acting drugs but many patients remain symptomatic despite monotherapy with these drugs. Combination therapy with LAMA and LABA increases the therapeutic benefit while minimizing dose-dependent side effects of long-acting bronchodilator therapy...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29331766/roflumilast-type-4-phosphodiesterase-inhibitor-attenuates-inflammation-in-rats-with-ulcerative-colitis-via-down-regulation-of-inos-and-elevation-of-camp
#9
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Samar A El-Adawy
BACKGROUND: Roflumilast (Rof), a phosphodiesterase 4 (PDE4) inhibitor, has been shown to be an effective agent in inflammatory diseases and marketed for chronic obstructive pulmonary disease. OBJECTIVE: This study was conducted to examine the potential anti-inflammatory effects of Rof in dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in rats and to investigate the molecular mechanisms underlying these effects. METHODS: Forty male Wistar rats were divided into four groups: normal control, colitis group (rats received 5% DSS in their drinking water continuously for 7 days), Rof group, and sulfasalazine (SLZ) group...
January 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29331313/predictors-of-exacerbation-risk-and-response-to-budesonide-in-patients-with-chronic-obstructive-pulmonary-disease-a-post-hoc-analysis-of-three-randomised-trials
#10
Mona Bafadhel, Stefan Peterson, Miguel A De Blas, Peter M Calverley, Stephen I Rennard, Kai Richter, Malin Fagerås
BACKGROUND: The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29331311/prediction-of-mortality-in-patients-with-chronic-obstructive-pulmonary-disease-with-the-new-global-initiative-for-chronic-obstructive-lung-disease-2017-classification-a-cohort-study
#11
Anne Gedebjerg, Szimonetta Komjáthiné Szépligeti, Laura-Maria Holm Wackerhausen, Erzsébet Horváth-Puhó, Ronald Dahl, Jens Georg Hansen, Henrik Toft Sørensen, Mette Nørgaard, Peter Lange, Reimar Wernich Thomsen
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification separates the spirometric 1-4 staging from the ABCD groups defined by symptoms and exacerbations. Little is known about how this new classification predicts mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to establish the predictive ability of the GOLD 2017 classification, compared with earlier classifications, for all-cause and respiratory mortality, both when using its main ABCD groups and when further subdividing according to spirometric 1-4 staging...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29329680/correlation-of-severity-of-chronic-obstructive-pulmonary-disease-with-potential-biomarkers
#12
Seema Singh, S K Verma, Santosh Kumar, M K Ahmad, Anuradha Nischal, S K Singh, R K Dixit
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha (TNF-a). The present study was designed to assess the serum cytokines [Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)] levels in chronic obstructive pulmonary disease (COPD) patients and they were correlated with severity of disease by spirometric measurements...
January 9, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29329563/pm2-5-induced-oxidative-stress-increases-intercellular-adhesion-molecule-1-expression-in-lung-epithelial-cells-through-the-il-6-akt-stat3-nf-%C3%AE%C2%BAb-dependent-pathway
#13
Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang, Yuh-Lien Chen
BACKGROUND: Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of air pollution that damages lung cells. However, the mechanisms remain to be elucidated. This study examines the effects of PMs on intercellular adhesion molecule-1 (ICAM-1) expression and the related mechanisms in vitro and in vivo. RESULT: The cytotoxicity, reactive oxygen species (ROS) generation, and monocyte adherence to A549 cells were more severely affected by treatment with O-PMs (organic solvent-extractable fraction of SRM1649b) than with W-PMs (water-soluble fraction of SRM1649b)...
January 12, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29329328/early-occurrence-of-inspiratory-muscle-weakness-in-parkinson-s-disease
#14
Guillaume Baille, Thierry Perez, David Devos, Valérie Deken, Luc Defebvre, Caroline Moreau
INTRODUCTION: In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of patients with advanced PD. The objective of the present study was to characterize lung function (under off-drug conditions) in early-stage PD patients at baseline and then again two years later. METHODS: Forty-one early-stage PD patients (mean ± SD age: 61...
2018: PloS One
https://www.readbyqxmd.com/read/29329142/whole-genome-methylation-profiling-of-peripheral-blood-mononuclear-cell-for-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-treated-with-corticosteroid
#15
Shih-Wei Lee, Julia Tzu-Ya Weng, Paul Wei-Che Hsu, Tzu-Yi Chuang, Chih-Wei Liu, Chung-Hsuan Chen, Lawrence Shih-Hsin Wu
OBJECTIVE: Although association studies in the general population may be relevant for determining susceptibility to chronic obstructive pulmonary disease (COPD), they may be less applicable for pharmacogenetics research in participants who have already acquired the disease. PATIENTS AND METHODS: A genome-wide methylation profiling (generated by HumanMethylation450 BeadChips study was performed on peripheral blood mononuclear cells of 24 patients with AECOPD (acute exacerbation COPD), with good and poor responsiveness to standard corticosteroid treatment...
January 10, 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29328885/radiographic-emphysema-circulating-bone-biomarkers-and-progressive-bone-mineral-density-loss-in-smokers
#16
Jessica Bon, Yingze Zhang, Joseph K Leader, Carl Fuhrman, Subashan Perera, Divay Chandra, Marnie Bertolet, Brenda Diergaarde, Susan L Greenspan, Frank C Sciurba
RATIONALE: Osteoporosis is common in individuals with chronic obstructive pulmonary disease. Lung-specific factors, including radiographic emphysema, independently associate with low bone mineral density (BMD) in cross-sectional smoking cohorts. However, factors associated with progressive bone loss in smokers are under-studied and largely unknown. OBJECTIVES: To determine the relationship between radiographic emphysema, circulating bone metabolism markers, and pulmonary function and accelerated BMD loss in smokers...
January 12, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29328848/high-risk-endovascular-aneurysm-repair-a-case-report
#17
Samanthi De Silva
Mr AB is a 66-year old gentleman who presented for elective endovascular aneurysm repair (EVAR) following a routine screening scan identifying a 5.5cm abdominal aortic aneurysm (AAA). He had a past history of chronic obstructive pulmonary disease (COPD) with FEV1/FVC ratio of 48% on pre-assessment. He was hypertensive with a history of ischaemic heart disease (IHD), which has remained asymptomatic following coronary artery bypass grafting (CABG) eight years prior to this presentation.
October 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29328439/prognostic-significance-of-hypoxia-inducible-factor-1%C3%AE-expression-in-patients-with-clear-cell-renal-cell-carcinoma
#18
Shuiqing Wu, Fen Jiang, Hongtao Wu, Yinhuai Wang, Ran Xu, Jian Cao, Qiong Lu, Xuan Zhu, Zhaohui Zhong, Xiaokun Zhao
The prognostic significance of hypoxia inducible factor-1α (HIF-1α) expression in tumors and the levels of preoperative hemoglobin in clear cell renal cell carcinoma (ccRCC), with or without concomitant chronic obstructive pulmonary disease (COPD), was investigated. A total of 128 patients with ccRCC who underwent surgery were analyzed using retrospective methods. Overall survival (OS) and progression free survival (PFS) were analyzed with clinicopathological variables, including preoperative hemoglobin levels, COPD and the levels of HIF‑1α expression, by Kaplan‑Meier survival analysis...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328031/metabolic-profile-of-serum-fatty-acids-in-patients-with-comorbidity-of-chro-nic-obstructive-pulmonary-disease-and-chronic-pancreatitis
#19
N Zhelezniakova, L Pasiyeshvili, T Bocharova, T Pasiieshvili, O Zhelezniakov
Objective - study of blood serum fatty acid metabolic profile in patients with comorbidity of COPD and chronic pancreatitis. 238 patients were examined, of them 131 with combined COPD and chronic pancreatitis and 107 with isolated COPD run. In study of fatty acid spectrum biological materials were prepared and gas chromatography analysis of blood serum lipid fatty acid spectrum performed according to methodology by L.V.Sazonenko et al. The study showed that COPD exacerbation was accompanied with by changes in contents of particular fatty acids both in patients with isolated COPD and in patients with comorbidity in comparison with almost healthy patients...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326536/first-time-isolation-of-mycobacterium-hassiacum-from-a-respiratory-sample
#20
Stefanie Deinhardt-Emmer, Steffen Höring, Christian Mura, Doris Hillemann, Beate Hermann, Svea Sachse, Jürgen Bohnert, Bettina Löffler
We describe the first isolation of Mycobacterium hassiacum, a rapid-growing, partial acid-resistant mycobacterium, in a respiratory specimen from a patient with exacerbated chronic obstructive pulmonary disease. To provide therapeutic recommendation for future cases, antibiotic susceptibility testing of 3 clinical isolates was performed by broth microdilution. All strains tested showed susceptibility to clarithromycin, imipenem, ciprofloxacin, and doxycycline. The role of M hassiacum as a respiratory pathogen remains unclear and needs to be evaluated by future reports...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
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