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https://www.readbyqxmd.com/read/29775776/the-probable-roles-of-valsartan-in-alleviating-chronic-obstructive-pulmonary-disease-following-co-exposure-to-cold-stress-and-fine-particulate-matter
#1
Jiangtao Liu, Lei Guo, Kai Zhang, Quanquan Song, Qiaozhen Wei, Qin Bian, Tingting Liang, Jingping Niu, Bin Luo
Angiotensin II (ANG II) might play an important role in the co-effects of cold stress and fine particulate matter (PM2.5 ) on chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate the roles of valsartan in alleviating COPD following co-exposure to cold stress and PM2.5 . Both the two intervention factors are carried out upon COPD rats with the intervention of valsartan. Blockade of angiotensin receptor by valsartan decreases the levels of malondialdehyde in the normal temperature and tumor necrosis factor-α under cold stress significantly...
May 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29774461/nonlinear-analysis-of-electrodermal-activity-signals-for-healthy-subjects-and-patients-with-chronic-obstructive-pulmonary-disease
#2
Serife Gokce Caliskan, Mehmet Dincer Bilgin, Mehmet Polatli
It is known that signals recorded from physiological systems represent nonlinear features. Several recent studies report that quantitative information about signal complexity is obtained by using nonlinear analysis algorithms. Chronic obstructive pulmonary disease (COPD) is one of the causes of mortality worldwide with an increasing prevalence. This study aims to investigate nonlinear parameters such as largest Lyapunov exponent (LLE) and correlation dimension of electrodermal activity signals recorded from healthy subjects and patients with COPD...
May 17, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29773969/cost-effectiveness-of-umeclidinium-compared-with-tiotropium-and-glycopyrronium-as-monotherapy-for-chronic-obstructive-pulmonary-disease-a-uk-perspective
#3
Dhvani Shah, Maurice Driessen, Nancy Risebrough, Timothy Baker, Ian Naya, Andrew Briggs, Afisi S Ismaila
Background: Cost-effectiveness of once-daily umeclidinium bromide (UMEC) was compared with once-daily tiotropium (TIO) and once-daily glycopyrronium (GLY) in patients with chronic obstructive pulmonary disease (COPD) from a UK National Health Service (NHS) perspective. Methods: A linked-equation model was implemented to estimate COPD progression, associated healthcare costs, exacerbations rates, life years (LY) and quality-adjusted LY (QALYs). Statistical risk equations for endpoints and resource use were derived from the ECLIPSE and TORCH studies, respectively...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29773606/optimising-experimental-research-in-respiratory-diseases-an-ers-statement
#4
Philippe Bonniaud, Aurélie Fabre, Nelly Frossard, Christophe Guignabert, Mark Inman, Wolfgang M Kuebler, Tania Maes, Wei Shi, Martin Stampfli, Stefan Uhlig, Eric White, Martin Witzenrath, Pierre-Simon Bellaye, Bruno Crestani, Oliver Eickelberg, Heinz Fehrenbach, Andreas Guenther, Gisli Jenkins, Guy Joos, Antoine Magnan, Bernard Maitre, Ulrich A Maus, Petra Reinhold, Juanita H J Vernooy, Luca Richeldi, Martin Kolb
Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective.The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models...
May 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29773294/gastroesophageal-reflux-symptoms-and-nasal-symptoms-affect-the-severity-of-bronchitis-symptoms-in-patients-with-chronic-obstructive-pulmonary-disease
#5
Koichi Hasegawa, Susumu Sato, Kazuya Tanimura, Yoshinori Fuseya, Kiyoshi Uemasu, Yoko Hamakawa, Atsuyasu Sato, Michiaki Mishima, Shigeo Muro, Toyohiro Hirai
BACKGROUND: Cough and sputum production (symptoms of bronchitis) are common in chronic obstructive pulmonary disease (COPD). Extrapulmonary comorbidities, such as gastroesophageal reflux disease (GERD) and post-nasal drip, also cause bronchitis symptoms. The impact of extrapulmonary comorbidities on the severity of bronchitis symptoms in COPD is unknown. The aim of this study was to quantify bronchitis symptoms and assess the impact of GERD and nasal symptoms on the severity of bronchitis symptoms in COPD...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773293/usefulness-of-the-forced-oscillation-technique-in-assessing-the-therapeutic-result-of-tracheobronchial-central-airway-obstruction
#6
Masanori Yasuo, Yoshiaki Kitaguchi, Fumiya Kinota, Makoto Kosaka, Kazuhisa Urushihata, Atsuhito Ushiki, Hiroshi Yamamoto, Satoshi Kawakami, Masayuki Hanaoka
BACKGROUND: Pulmonary function tests (PFTs) comprise the traditional method for detecting central airway obstruction (CAO) and evaluating therapeutic effects, but are effort-dependent. By contrast, the forced oscillation technique (FOT) is performed during tidal breathing in an effort-independent mode and is universally used to assess respiratory function in patients with chronic obstructive pulmonary disease (COPD) and asthma. We used the FOT to measure airway resistance and reactance in patients with CAO before and after interventional bronchoscopy and compared the results to data obtained using PFTs...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773292/health-related-quality-of-life-measurement-in-patients-with-chronic-respiratory-failure
#7
REVIEW
Toru Oga, Wolfram Windisch, Tomohiro Handa, Toyohiro Hirai, Kazuo Chin
The improvement of health-related quality of life (HRQL) is an important goal in managing patients with chronic respiratory failure (CRF) receiving long-term oxygen therapy (LTOT) and/or domiciliary noninvasive ventilation (NIV). Two condition-specific HRQL questionnaires have been developed to specifically assess these patients: the Maugeri Respiratory Failure Questionnaire (MRF) and the Severe Respiratory Insufficiency Questionnaire (SRI). The MRF is more advantageous in its ease of completion; conversely, the SRI measures diversified health impairments more multi-dimensionally and discriminatively with greater balance, especially in patients receiving NIV...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773291/cost-utility-of-non-invasive-mechanical-ventilation-analysis-and-implications-in-acute-respiratory-failure-a-brief-narrative-review
#8
REVIEW
Antonello Nicolini, Sven Stieglitz, Pierre Bou-Khalil, Antonio Esquinas
The growing interest in the quality of patient care at the levels of the health care managers, insurance companies, and health professionals is evident. Further, the growing population requires good quality health services. In this review, we analyzed the cost-effectiveness of noninvasive ventilation (NIV) in an acute setting for the treatment of respiratory failure. The strength of this review is that it identified and summarized the most relevant studies regarding various aspects of the cost-utility of NIV in an acute setting...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29772569/evaluation-of-inhaled-procaterol-for-potential-assist-use-in-patients-with-stable-chronic-obstructive-pulmonary-disease
#9
Norio Kodaka, Toru Yamagishi, Kayo Watanabe, Kumiko Kishimoto, Chihiro Nakano, Takeshi Oshio, Kumiko Niitsuma, Nagashige Shimada, Hiroto Matsuse
OBJECTIVES: International guidelines recommend the use of long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease (COPD), but the usefulness of short-acting bronchodilator assist use for stable COPD remains uncertain. The purpose of the present study was to objectively demonstrate the effects of assist use of procaterol, a short-acting -agonist, on the respiratory mechanics of stable COPD patients treated with a long-acting bronchodilator using forced oscillation technique (FOT) and conventional spirometry...
May 17, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29771599/clinical-characterization-of-children-with-resistant-airflow-obstruction-a-multicenter-study
#10
Sankaran Krishnan, Allen J Dozor, Leonard Bacharier, Jason E Lang, Charles G Irvin, David Kaminsky, Harold J Farber, Lynn Gerald, Mark Brown, Janet T Holbrook, Robert A Wise, Julie Ryu, Sonali Bose, Yasin Razan, Joy Saams, Robert J Henderson, William G Teague
OBJECTIVE: To characterize a cohort of children with airflow limitation resistant to bronchodilator (BD) therapy. METHODS: Pulmonary function tests performed in children 6-17 years of age at 15 centers in a clinical research consortium were screened for resistant airflow limitation, defined as a post-BD FEV1 and/or an FEV1 /FVC less than the lower limits of normal. Demographic and clinical data were analyzed for associations with pulmonary function. RESULTS: 582 children were identified...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29771274/identification-of-chronic-obstructive-pulmonary-disease-axes-that-predict-all-cause-mortality-the-copdgene-study
#11
Gregory L Kinney, Stephanie A Santorico, Kendra A Young, Michael H Cho, Peter J Castaldi, Raul San José Estépar, James C Ross, Jennifer G Dy, Barry J Make, Elizabeth A Regan, David A Lynch, Douglas C Everett, Sharon M Lutz, Edwin K Silverman, George R Washko, James D Crapo, John E Hokanson
Chronic Obstructive Pulmonary Disease (COPD) is a syndrome caused by damage to the lungs resulting in decreased pulmonary function and reduced structural integrity. Pulmonary function testing (PFT) is currently used to diagnose and stratify COPD into severity groups and chest computed tomography (CT) imaging is often used to assess structural changes in the lungs. We hypothesized that the combination of PFT and CT phenotypes would provide a more powerful tool for assessing underlying morphologic differences associated with pulmonary function in COPD than PFT alone...
May 16, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29771095/-a-progress-of-macrolides-therapy-for-chronic-rhinosinusitis
#12
REVIEW
S Shen, C S Wang
Macrolides are a type of antibiotics with macrocyclic lactone ring, which have been commonly used in the treatment of diffuse panbronchiolitis, chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis and other diseases. Macrolides not only have effect on antibacterial, but also effect on anti-inflammatory and immunoregulation. Chronic rhinosinusitis (CRS) is a common disease entity of infectious and inflammatory diseases that involved in nasal cavity and nasal sinuses, with various clinical phenotypes...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770729/group-sequential-designs-for-negative-binomial-outcomes
#13
Tobias Mütze, Ekkehard Glimm, Heinz Schmidli, Tim Friede
Count data and recurrent events in clinical trials, such as the number of lesions in magnetic resonance imaging in multiple sclerosis, the number of relapses in multiple sclerosis, the number of hospitalizations in heart failure, and the number of exacerbations in asthma or in chronic obstructive pulmonary disease (COPD) are often modeled by negative binomial distributions. In this manuscript, we study planning and analyzing clinical trials with group sequential designs for negative binomial outcomes. We propose a group sequential testing procedure for negative binomial outcomes based on Wald statistics using maximum likelihood estimators...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29770573/looking-into-the-eye-of-patients-with-chronic-obstructive-pulmonary-disease-an-opportunity-for-better-microvascular-profiling-of-these-complex-patients
#14
REVIEW
Anouk W Vaes, Martijn A Spruit, Jan Theunis, Nandu Goswami, Lowie E Vanfleteren, Frits M E Franssen, Emiel F M Wouters, Patrick De Boever
Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD...
May 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29770542/the-effect-of-health-coaching-on-treatment-adherence-self-efficacy-and-quality-of-life-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Derya Tülüce, Sevinç Kutlutürkan
AIM: The aim of this study was to determine the impact of health coaching on respiratory functions, treatment adherence, self-efficacy, and quality of life in chronic obstructive pulmonary disease patients. METHODS: This study was conducted as an experimental study with non-randomized control group in chronic obstructive pulmonary disease individuals. The study group included a total of 54 chronic obstructive pulmonary disease patients (27 patients both health coaching and control groups), was selected between 13 July 2016 and 2 July 2017...
May 16, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29770201/recent-advances-in-managing-septal-defects-ventricular-septal-defects-and-atrioventricular-septal-defects
#16
REVIEW
P Syamasundar Rao, Andrea D Harris
This review discusses the management of ventricular septal defects (VSDs) and atrioventricular septal defects (AVSDs). There are several types of VSDs: perimembranous, supracristal, atrioventricular septal, and muscular. The indications for closure are moderate to large VSDs with enlarged left atrium and left ventricle or elevated pulmonary artery pressure (or both) and a pulmonary-to-systemic flow ratio greater than 2:1. Surgical closure is recommended for large perimembranous VSDs, supracristal VSDs, and VSDs with aortic valve prolapse...
2018: F1000Research
https://www.readbyqxmd.com/read/29768880/tio%C3%A2-nps-induce-dna-damage-in-lymphocytes-from-healthy-individuals-and-patients-with-respiratory-diseases-an-ex-vivo-in-vitro-study
#17
Ilham F Osman, Mojgan Najafzadeh, Vyom Sharma, Ritesh K Shukla, B K Jacob, Alok Dhawan, D Anderson
Little is known of the effects of nanoparticles in human systems, let alone in diseased individuals and nanotechnology has preceded nanotoxicology. Therefore, the effects of titanium dioxide (TiO2) nanoparticles in peripheral blood lymphocytes from patients with respiratory diseases [lung cancer, chronic obstructive pulmonary disease (COPD) and asthma] were compared with those in healthy Individuals, to determine differences in sensitivity to nanochemical insult. The Comet assay was performed according to recommended guidelines...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29767845/final-results-from-a-defibrotide-treatment-ind-study-for-patients-with-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome
#18
Nancy A Kernan, Stephan Grupp, Angela R Smith, Sally Arai, Brandon Triplett, Joseph H Antin, Leslie Lehmann, Tsiporah Shore, Vincent T Ho, Nancy Bunin, Massimo Iacobelli, Wei Liang, Robin Hume, William Tappe, Robert Soiffer, Paul Richardson
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of haematopoietic stem cell transplant (HSCT) conditioning and chemotherapy. Defibrotide is approved for treatment of hepatic VOD/SOS with pulmonary or renal dysfunction [i.e., multi-organ dysfunction (MOD)] after HSCT in the United States and severe VOD/SOS after HSCT in patients aged older than 1 month in the European Union. Defibrotide was available as an investigational drug by an expanded-access treatment programme (T-IND; NCT00628498)...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29767774/common-and-rare-variants-genetic-association-analysis-of-cigarettes-per-day-among-ever-smokers-in-copd-cases-and-controls
#19
Sharon M Lutz, Brittni Frederiksen, Ferdouse Begum, Merry-Lynn McDonald, Michael H Cho, Brian Hobbs, Margaret M Parker, Dawn L DeMeo, Craig P Hersh, Marissa Eringher, Kendra Young, Lai Jiang, Marilyn G Foreman, Greg L Kinney, Barry J Make, David A Lomas, Per Bakke, Amund Gulsvik, James D Crapo, Edwin K Silverman, Terri H Beaty, John E Hokanson
Introduction: Cigarette smoking is a major environmental risk factor for many diseases, including chronic obstructive pulmonary disease (COPD). There are shared genetic influences on cigarette smoking and COPD. Genetic risk factors for cigarette smoking in cohorts enriched for COPD are largely unknown. Methods: We performed genome-wide association analyses for average cigarettes per day (CPD) across the COPDGene Non-Hispanic White (NHW) (n=6,659) and African American (AA) (n=3,260), GenKOLS (n=1,671), and ECLIPSE (n=1,942) cohorts...
May 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29767634/measurement-and-estimation-of-human-forced-expiratory-noise-parameters-using-a-microphone-with-a-stethoscope-head-and-a-lapel-microphone
#20
Anna Yur'evna Glazova, Vladimir I Korenbaum, Anatoly E Kostiv, Oksana I Kabancova, Alexander A Tagiltcev, Svetlana N Shin
The time signature of tracheal noise in the 200-2000 Hz frequency band recorded during a forced expiratory manoeuvre (FETa) is a promising tool for diagnosis of bronchial obstructions. FETa is typically registered using a microphone with a stethoscope head placed on the neck over the trachea (stethoscope sensor). We studied basic time and spectral parameters of forced expiratory tracheal noises with a microphone placed near the mouth (lapel microphone, outside the flow of exhaled air) and compared these with measurements via stethoscope sensor, with the aim of providing patient home monitoring via standard personal computer facilities...
May 16, 2018: Physiological Measurement
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