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https://www.readbyqxmd.com/read/29675514/bonding-of-composite-to-base-materials-effects-of-adhesive-treatments-on-base-surface-properties-and-bond-strength
#1
Konstantinos Anastasiadis, Elisabeth A Koulaouzidou, Georgios Palaghias, George Eliades
PURPOSE: To evaluate the effects on the surface properties (morphology, roughness, microhardness, composition) and bond strength to composite of four types of base cements (Equia-Fil/EQF, Angelus white MTA/MTA, Biodentin/ BDN and IRM/IRM) when treated with phosphoric acid etching (PAE) or two self-etch adhesives (Select One Prime & Bond and Clearfil S3 Bond). MATERIALS AND METHODS: Disk-shaped specimens were prepared and stored until complete setting. The surfaces before and after treatments were examined by stereomicroscopy, optical profilometry, ATR-FTIR, and LV-SEM/EDX...
April 19, 2018: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29668758/clostridium-sordellii-outer-spore-proteins-maintain-spore-structural-integrity-and-promote-bacterial-clearance-from-the-gastrointestinal-tract
#2
Rebecca Rabi, Sarah Larcombe, Rommel Mathias, Sheena McGowan, Milena Awad, Dena Lyras
Bacterial spores play an important role in disease initiation, transmission and persistence. In some species, the exosporium forms the outermost structure of the spore and provides the first point of contact between the spore and the environment. The exosporium may also be involved in spore adherence, protection and germination. Clostridium sordellii is a highly lethal, spore forming pathogen that causes soft-tissue infections, enteritis and toxic-shock syndrome. Despite the importance of C. sordellii spores in disease, spore proteins from this bacterium have not been defined or interrogated functionally...
April 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29627898/cross-sectional-networks-of-depressive-symptoms-before-and-after-antidepressant-medication-treatment
#3
Fionneke M Bos, Eiko I Fried, Steven D Hollon, Laura F Bringmann, Sona Dimidjian, Robert J DeRubeis, Claudi L H Bockting
PURPOSE: Recent reviews have questioned the efficacy of selective serotonin reuptake inhibitors (SSRIs) above placebo response, and their working mechanisms remain unclear. New approaches to understanding the effects of SSRIs are necessary to enhance their efficacy. The aim of this study was to explore the possibilities of using cross-sectional network analysis to increase our understanding of symptom connectivity before and after SSRI treatment. METHODS: In two randomized controlled trials (total N = 178), we estimated Gaussian graphical models among 20 symptoms of the Beck Depression Inventory-II before and after 8 weeks of treatment with the SSRI paroxetine...
April 7, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29625109/generation-of-splice-switching-oligonucleotides-targeting-the-cockayne-syndrome-group-b-gene-product-in-order-to-change-the-diseased-cell-state
#4
Yooksil Sin, Futaba Makimura, Masafumi Saijo, Satoshi Obika
Cockayne syndrome (CS) is a severe disorder with no effective treatment. The Cockayne syndrome group B (CSB) gene is one gene responsible for CS and also causes UV sensitive syndrome (UVS S), a disorder that causes mild symptoms. How the CSB gene determines a patient's fate is unknown, but one intriguing point is that in UVS S patient cell, there are nonsense mutations in both alleles at the same position in each upstream region of the PiggyBac transposable element derived 3 (PGBD3) inserted region. In contrast, in CS patient cells, there is at least one allele with several mutations downstream of the PGBD3 inserted region, or there are homozygous mutations in exon 1...
April 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29606453/characterization-of-wheat-endoplasmic-reticulum-oxidoreductin-1-and-its-application-in-chinese-steamed-bread
#5
Guang Liu, JingJing Wang, Yi Hou, Yan-Bo Huang, JiaJia Wang, Cunzhi Li, ShiJun Guo, Lin Li, Song-Qing Hu
This study investigated characteristics of recombinant wheat Endoplasmic Reticulum Oxidoreductin 1 (wEro1) and its influence on Chinese steamed bread (CSB) qualities. The purified wEro1 monomer, which contained two conserved redox active motif sites, bound to flavin adenine dinucleotide (FAD) cofactor with a molecular weight of ∼47 kDa. wEro1 catalyzed the reduction of both bound and free FAD, and its reduction activity of free FAD reached 7.8 U/mg. Moreover, wEro1 catalyzed the oxidation of dithiothreitol and wheat protein disulfide isomerase (wPDI)...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29572252/functional-and-clinical-relevance-of-novel-mutations-in-a-large-cohort-of-patients-with-cockayne-syndrome
#6
Nadege Calmels, Elena Botta, Nan Jia, Heather Fawcett, Tiziana Nardo, Yuka Nakazawa, Manuela Lanzafame, Shinichi Moriwaki, Katsuo Sugita, Masaya Kubota, Cathy Obringer, Marie-Aude Spitz, Miria Stefanini, Vincent Laugel, Donata Orioli, Tomoo Ogi, Alan Robert Lehmann
BACKGROUND: Cockayne syndrome (CS) is a rare, autosomal recessive multisystem disorder characterised by prenatal or postnatal growth failure, progressive neurological dysfunction, ocular and skeletal abnormalities and premature ageing. About half of the patients with symptoms diagnostic for CS show cutaneous photosensitivity and an abnormal cellular response to UV light due to mutations in either the ERCC8 / CSA or ERCC6 / CSB gene. Studies performed thus far have failed to delineate clear genotype-phenotype relationships...
March 23, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29548287/randomised-controlled-trial-to-test-the-effectiveness-of-a-locally-produced-ready-to-use-supplementary-food-rusf-in-preventing-growth-faltering-and-improving-micronutrient-status-for-children-under-two-years-in-cambodia-a-study-protocol
#7
Bindi Borg, Seema Mihrshahi, Mark Griffin, Daream Sok, Chamnan Chhoun, Arnaud Laillou, Jacques Berger, Frank T Wieringa
BACKGROUND: Existing ready-to-use supplementary and therapeutic foods (RUSFs and RUTFs) have had limited acceptance and effectiveness in Cambodia. This has hampered the treatment and prevention of child malnutrition. An innovative, locally produced, multiple micronutrient fortified lipid-based nutrient supplement (LNS) has been developed for use as an RUSF. Unlike most RUSFs, which contain milk, this product contains fish as the animal protein. Few RUSFs have been formulated using non-milk animal-source foods and they have not been widely tested...
March 16, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29545921/csa-and-csb-play-a-role-in-the-response-to-dna-breaks
#8
Barbara Pascucci, Alessandra Fragale, Veronica Marabitti, Giuseppe Leuzzi, Angelo Salvatore Calcagnile, Eleonora Parlanti, Annapaola Franchitto, Eugenia Dogliotti, Mariarosaria D'Errico
CS proteins have been involved in the repair of a wide variety of DNA lesions. Here, we analyse the role of CS proteins in DNA break repair by studying histone H2AX phosphorylation in different cell cycle phases and DNA break repair by comet assay in CS-A and CS-B primary and transformed cells. Following methyl methane sulphate treatment a significant accumulation of unrepaired single strand breaks was detected in CS cells as compared to normal cells, leading to accumulation of double strand breaks in S and G2 phases...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29543572/adolescent-compulsive-sexual-behavior-is-it-a-unique-psychological-phenomenon
#9
Yaniv Efrati
BACKGROUND: Adolescent compulsive sexual behavior (CSB), and its associations with other personality predispositions (attachment orientations, temperament), gender, religiosity, and psychopathological tendencies. Five alternative empirical models were examined, all based on current theory and research on CSB. METHODS: The sample include 311 high-school adolescents (184 boys, 127 girls) ranging in age from 16 to 18 (M  = 16.94, SD  = .65) and enrolled in the eleventh (43...
March 15, 2018: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29533833/sediment-exchange-to-mitigate-pollutant-exposure-in-urban-soil
#10
Daniel Walsh, Katherine Glass, Samantha Morris, Horace Zhang, Isabel McRae, Noel Anderson, Alysha Alfieri, Sara Perl Egendorf, Shana Holberton, Shahandeh Owrang, Zhongqi Cheng
Urban soil is an ongoing source for lead (Pb) and other pollutant exposure. Sources of clean soil that are locally-available, abundant and inexpensive are needed to place a protective cover layer over degraded urban soil to eliminate direct and indirect pollutant exposures. This study evaluates a novel sediment exchange program recently established in New York City (NYC Clean Soil Bank, CSB) and found that direct exchange of surplus sediment extracted from urban construction projects satisfies these criteria...
March 10, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29529160/impact-of-food-supplements-on-hemoglobin-iron-status-and-inflammation-in-children-with-moderate-acute-malnutrition-a-2-%C3%A3-2-%C3%A3-3-factorial-randomized-trial-in-burkina-faso
#11
Bernardette Cichon, Christian Fabiansen, Ann-Sophie Iuel-Brockdorf, Charles W Yaméogo, Christian Ritz, Vibeke B Christensen, Suzanne Filteau, André Briend, Kim F Michaelsen, Henrik Friis
Background: Children with moderate acute malnutrition (MAM) are treated with lipid-based nutrient supplements (LNSs) or corn-soy blends (CSBs) but little is known about the impact of these supplements on hemoglobin, iron status, and inflammation. Objective: The objective of this study was to investigate the impact of supplementary foods for treatment of MAM on hemoglobin, iron status, inflammation, and malaria. Design: A randomized 2 × 2 × 3 factorial trial was conducted in Burkina Faso...
February 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29528404/spatio-temporal-dynamics-of-sulfur-bacteria-during-oxic-anoxic-regime-shifts-in-a-seasonally-stratified-lake
#12
Muhe Diao, Jef Huisman, Gerard Muyzer
Sulfate-reducing bacteria (SRB) and sulfur-oxidizing bacteria (SOB) drive major transformations in the sulfur cycle, and play vital roles in oxic-anoxic transitions in lakes and coastal waters. However, information on the succession of these sulfur bacteria in seasonally stratified lakes using molecular biological techniques is scarce. Here, we used 16S rRNA gene amplicon sequencing to study the spatio-temporal dynamics of sulfur bacteria during oxic-anoxic regime shifts in Lake Vechten. Oxygen and sulfate were mixed throughout the water column in winter and early spring...
March 8, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29506668/csb-an-emerging-actionable-target-for-cancer-therapy
#13
Luca Proietti-De-Santis, Alessio Balzerano, Giorgio Prantera
The DNA repair protein Cockayne syndrome group B (CSB) is frequently found overexpressed in cancer cells. High CSB levels favor tumor cell proliferation whilst inhibiting apoptosis. Conversely, the suppression of CSB has significant anticancer effects. In this manuscript we describe CSB downregulation as a potential new therapeutic approach in cancer.
March 2018: Trends in Cancer
https://www.readbyqxmd.com/read/29422660/deep-intronic-variation-in-splicing-regulatory-element-of-the-ercc8-gene-associated-with-severe-but-long-term-survival-cockayne-syndrome
#14
Audrey Schalk, Géraldine Greff, Nathalie Drouot, Cathy Obringer, Hélène Dollfus, Vincent Laugel, Jamel Chelly, Nadège Calmels
Cockayne syndrome is an autosomal recessive multisystem disorder characterized by intellectual disability, microcephaly, severe growth failure, sensory impairment, peripheral neuropathy, and cutaneous sensitivity. This rare disease is linked to disease-causing variations in the ERCC6 (CSB) and ERCC8 (CSA) genes. Various degrees of severity have been described according to age at onset and survival, without any clear genotype-phenotype correlation. All types of nucleotide changes have been observed in CS genes, including splice variations mainly affecting the splice site consensus sequences...
February 8, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29417712/structure-and-cis-regulatory-analysis-of-a-drosophila-grainyhead-neuroblast-enhancer
#15
Alexander Kuzin, Svetlana Smith, Thomas Brody, Ward F Odenwald
Evolutionary analysis of cis-regulatory DNA reveals that enhancers consist of clusters of conserved sequence blocks (CSBs) that are made up of both unique and repeated sequence elements. Our goal has been to address aspects of Drosophila neuroblast (NB) enhancer structure, including the basis for their spatial and temporal regulation and the functional significance of their individual CSBs. A search for temporally restricted CNS NB enhancers identified one within the transcription factor grainyhead (grh) gene locus...
February 8, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#16
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29338261/nature-of-the-three-electron-bond
#17
David Danovich, Cina Foroutan-Nejad, Philippe C Hiberty, Sason Shaik
We analyze the properties of 15 3-electron bonds, which include σ-3-electron-bonds, such as dihalide radical anions and di-noble gas radical cations, π-3-electron-bonds as in hydrazine radical cations, and doubly-π-(3e)-bonded species such as O2 , FeO+ , S2 , etc. The primary analytical tool is the breathing-orbital valence-bond (BOVB) method, which enables us to quantify the charge shift resonance energy (RECS ) of the three electrons, and the bond dissociation energies (De ). BOVB is tested reliable against MRCI calculations...
February 22, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29333201/dispositional-mindfulness-shame-and-compulsive-sexual-behaviors-among-men-in-residential-treatment-for-substance-use-disorders
#18
Meagan J Brem, Ryan C Shorey, Scott Anderson, Gregory L Stuart
Approximately 31% of men in treatment for a substance use disorders (SUD) engage in compulsive sexual behavior (CSB). Shame, a well-documented consequence of CSB, increases the likelihood of relapse following treatment for SUDs. Despite the risk of relapse, prior research has not investigated factors that may attenuate the relation between CSB and shame. Dispositional mindfulness is one such factor known to mitigate shame. However, researchers have yet to examine dispositional mindfulness as a moderator of the relationship between CSB and shame among a sample of men in treatment for SUDs...
December 2017: Mindfulness
https://www.readbyqxmd.com/read/29322938/mdd-carb-a-combinatorial-model-for-the-identification-of-protein-carbonylation-sites-with-substrate-motifs
#19
Hui-Ju Kao, Shun-Long Weng, Kai-Yao Huang, Fergie Joanda Kaunang, Justin Bo-Kai Hsu, Chien-Hsun Huang, Tzong-Yi Lee
BACKGROUND: Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is related to a number of metabolic or aging diseases including diabetes, chronic lung disease, Parkinson's disease, and Alzheimer's disease. Due to the lack of computational methods dedicated to exploring motif signatures of protein carbonylation sites, we were motivated to exploit an iterative statistical method to characterize and identify carbonylated sites with motif signatures...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29322920/investigation-and-identification-of-functional-post-translational-modification-sites-associated-with-drug-binding-and-protein-protein-interactions
#20
Min-Gang Su, Julia Tzu-Ya Weng, Justin Bo-Kai Hsu, Kai-Yao Huang, Yu-Hsiang Chi, Tzong-Yi Lee
BACKGROUND: Protein post-translational modification (PTM) plays an essential role in various cellular processes that modulates the physical and chemical properties, folding, conformation, stability and activity of proteins, thereby modifying the functions of proteins. The improved throughput of mass spectrometry (MS) or MS/MS technology has not only brought about a surge in proteome-scale studies, but also contributed to a fruitful list of identified PTMs. However, with the increase in the number of identified PTMs, perhaps the more crucial question is what kind of biological mechanisms these PTMs are involved in...
December 21, 2017: BMC Systems Biology
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