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https://www.readbyqxmd.com/read/27910283/feeding-behaviors-during-home-based-treatment-of-moderate-acute-malnutrition-using-corn-soy-blends-or-lipid-based-nutrient-supplements
#1
Ann-Sophie Iuel-Brockdorf, Albertine Ouedraogo, Christian Ritz, Tania Aase Draebel, Per Ashorn, Suzanne Filteau, Kim F Michaelsen
Feeding behaviors have an important impact on children's nutritional status and are essential to consider when implementing nutrition programs. The objective of this study was to explore and compare feeding behaviors related to supplementary feeding with corn-soy blends (CSB) and lipid-based nutrient supplements (LNS) based on best practice feeding behaviors. The study was conducted as part of a randomized controlled trial assessing the effectiveness of new formulations of CSB and LNS and comprised 1,546 children from 6 to 23 months...
December 2, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27906014/acceptability-and-use-of-ready-to-use-supplementary-food-compared-to-corn-soy-blend-as-a-targeted-ration-in-an-hiv-program-in-rural-haiti-a-qualitative-study
#2
Anne G Beckett, Debbie Humphries, J Gregory Jerome, Jessica E Teng, Patrick Ulysse, Louise C Ivers
BACKGROUND: Ready-to-use supplementary food (RUSF) is increasingly used as a component of food rations for adults with HIV. METHODS: We undertook a qualitative study to evaluate the acceptability and use of peanut-based RUSF compared to corn-soy blend (CSB) among adults living with HIV in rural Haiti who had been enrolled in a prospective, randomized trial comparing the impact of those rations. A total of 13 focus groups were conducted with 84 participants-42 selected from the RUSF arm of the study, and 42 from the CSB arm-using a guide with pre-designated core topics and open-ended questions...
February 17, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27862282/a-non-redundant-protein-rna-docking-benchmark-version-2-0
#3
Chandran Nithin, Sunandan Mukherjee, Ranjit Prasad Bahadur
We present an updated version of the protein-RNA docking benchmark, which we first published four years back. The non-redundant protein-RNA docking benchmark version 2.0 consists of 126 test cases, a threefold increase in number compared to its previous version. The present version consists of 21 unbound-unbound cases, of which, in 12 cases, the unbound RNAs are taken from another complex. It also consists of 95 unbound-bound cases where only the protein is available in the unbound state. Besides, we introduce 10 new bound-unbound cases where only the RNA is found in the unbound state...
November 12, 2016: Proteins
https://www.readbyqxmd.com/read/27855199/the-values-of-coronary-circulating-mirnas-in-patients-with-atrial-fibrillation
#4
Guiyu Xu, Yuxia Cui, Zhenghua Jia, Yunan Yue, Shuixiang Yang
The mechanism of miRNA regulation in atrial fibrillation (AF) occurrence and development is still unclear, especially, the regulating values of coronary circulating miRNAs has not been reported. Based on our AF radiofrequency ablation clinical practice and previous miRNA study, we proposed a hypothesis that the coronary circulating miRNA might much better reflect the regulating state and metabolic level of myocardial miRNA in AF patient. To investigate the regulating values of coronary circulation miRNA, 90 AF patients were selected and compared with 90 healthy subjects, the changes of coronary circulating miRNA differential expression profile in the whole genome were observed in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27797766/ymap-an-automated-method-to-map-yeast-variants-to-protein-modifications-and-functional-regions
#5
Ahmed Arslan, Vera van Noort
: Recent advances in sequence technology result in large datasets of sequence variants. For the human genome, several tools are available to predict the impact of these variants on gene and protein functions. However, for model organisms such as yeast such tools are lacking, specifically to predict the effect of protein sequence altering variants on the protein level. We present a python framework that enables users to map in a fully automated fashion large set of variants to protein functional regions and post-translationally modified residues...
October 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27791127/cockayne-syndrome-group-a-and-b-proteins-converge-on-transcription-linked-resolution-of-non-b-dna
#6
Morten Scheibye-Knudsen, Anne Tseng, Martin Borch Jensen, Karsten Scheibye-Alsing, Evandro Fei Fang, Teruaki Iyama, Sanjay Kumar Bharti, Krisztina Marosi, Lynn Froetscher, Henok Kassahun, David Mark Eckley, Robert W Maul, Paul Bastian, Supriyo De, Soumita Ghosh, Hilde Nilsen, Ilya G Goldberg, Mark P Mattson, David M Wilson, Robert M Brosh, Myriam Gorospe, Vilhelm A Bohr
Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes. Although the pathogenesis of Cockayne syndrome has remained elusive, recent work implicates mitochondrial dysfunction in the disease progression. Here, we present evidence that loss of CSA or CSB in a neuroblastoma cell line converges on mitochondrial dysfunction caused by defects in ribosomal DNA transcription and activation of the DNA damage sensor poly-ADP ribose polymerase 1 (PARP1). Indeed, inhibition of ribosomal DNA transcription leads to mitochondrial dysfunction in a number of cell lines...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27787929/compulsive-sexual-behavior-prefrontal-and-limbic-volume-and-interactions
#7
Casper Schmidt, Laurel S Morris, Timo L Kvamme, Paula Hall, Thaddeus Birchard, Valerie Voon
BACKGROUND: Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV). METHODS: Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry...
October 27, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27760194/kingella-kingae-expresses-four-structurally-distinct-polysaccharide-capsules-that-differ-in-their-correlation-with-invasive-disease
#8
Kimberly F Starr, Eric A Porsch, Patrick C Seed, Christian Heiss, Radnaa Naran, L Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W St Geme
Kingella kingae is an encapsulated gram-negative organism that is a common cause of osteoarticular infections in young children. In earlier work, we identified a glycosyltransferase gene called csaA that is necessary for synthesis of the [3)-β-GalpNAc-(1→5)-β-Kdop-(2→] polysaccharide capsule (type a) in K. kingae strain 269-492. In the current study, we analyzed a large collection of invasive and carrier isolates from Israel and found that csaA was present in only 47% of the isolates. Further examination of this collection using primers based on the sequence that flanks csaA revealed three additional gene clusters (designated the csb, csc, and csd loci), all encoding predicted glycosyltransferases...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27744065/a-coumarin-based-schiff-base-probe-for-selective-fluorescence-detection-of-al-3-and-its-application-in-live-cell-imaging
#9
Bhaskar Sen, Sanjoy Kumar Sheet, Romita Thounaojam, Ramen Jamatia, Amarta Kumar Pal, Kripamoy Aguan, Snehadrinarayan Khatua
A new coumarin based Schiff base compound, CSB-1 has been synthesized to detect metal ion based on the chelation enhanced fluorescence (CHEF). The cation binding properties of CSB-1 was thoroughly examined in UV-vis and fluorescence spectroscopy. In fluorescence spectroscopy the compound showed high selectivity toward Al(3+) ion and the Al(3+) can be quantified in mixed aqueous buffer solution (MeOH: 0.01M HEPES Buffer; 9:1; v/v) at pH7.4 as well as in BSA media. The fluorescence intensity of CSB-1 was enhanced by ~24 fold after addition of only five equivalents of Al(3+)...
October 11, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27714528/adhesion-of-multimode-adhesives-to-enamel-and-dentin-after-one-year-of-water-storage
#10
Paulo Moreira Vermelho, André Figueiredo Reis, Glaucia Maria Bovi Ambrosano, Marcelo Giannini
OBJECTIVES: This study aimed to evaluate the ultramorphological characteristics of tooth-resin interfaces and the bond strength (BS) of multimode adhesive systems to enamel and dentin. METHODS: Multimode adhesives (Scotchbond Universal (SBU) and All-Bond Universal) were tested in both self-etch and etch-and-rinse modes and compared to control groups (Optibond FL and Clearfil SE Bond (CSB)). Adhesives were applied to human molars and composite blocks were incrementally built up...
October 7, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27704748/a-study-revealing-the-key-aroma-compounds-of-steamed-bread-made-by-chinese-traditional-sourdough
#11
Guo-Hua Zhang, Tao Wu, Faizan A Sadiq, Huan-Yi Yang, Tong-Jie Liu, Hui Ruan, Guo-Qing He
Aroma of Chinese steamed bread (CSB) is one of the important parameters that determines the overall quality attributes and consumer acceptance. However, the aroma profile of CSB still remains poorly understood, mainly because of relying on only a single method for aroma extraction in previous studies. Therefore, the objective of this study was to determine the volatile aroma compounds of five different samples of CSB using three different aroma extraction methods, namely solid-phase microextraction (SPME), simultaneous distillation-extraction (SDE), and purge and trap (P&T)...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27696486/nucleotide-excision-repair-finely-tuned-molecular-orchestra-of-early-pre-incision-events
#12
Qianzheng Zhu, Altaf A Wani
Nucleotide excision repair (NER) eliminates a broad variety of helix-distorting DNA lesions that can otherwise cause genomic instability. NER comprises two distinct sub-pathways: global genomic NER (GG-NER) operating throughout the genome, and transcription-coupled NER (TC-NER) preferentially removing DNA lesions from transcribing DNA strands of transcriptionally active genes. Several NER factors undergo post-translational modifications, including ubiquitination, occurring swiftly and reversibly at DNA lesion sites...
October 1, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27695740/nitrogen-management-for-corn-and-groundwater-quality-in-upper-midwest-irrigated-sands
#13
Anne M Struffert, John C Rubin, Fabián G Fernández, John A Lamb
Groundwater contamination from NO-N leaching in corn ( L.) production with coarse-textured soils poses an environmental concern. Our objectives were to evaluate NO-N leaching in continuous corn (CC), corn after soybean ( L.) (CSb), and soybean after corn (SbC) in irrigated sandy soils in Minnesota related to (i) N rate using best management practices of split-N application, (ii) a split-N application and single preplant applications of enhanced-efficiency fertilizers (EEF), and (iii) residual N treatment in SbC...
September 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27659453/evolutionary-conservation-of-ebola-virus-proteins-predicts-important-functions-at-residue-level
#14
Ahmed Arslan, Vera van Noort
MOTIVATION: The recent outbreak of Ebola virus disease (EVD) resulted in a large number of human deaths. Due to this devastation, the Ebola virus has attracted renewed interest as model for virus evolution. Recent literature on Ebola virus (EBOV) has contributed substantially to our understanding of the underlying genetics and its scope with reference to the 2014 outbreak. But no study yet, has focused on the conservation patterns of EBOV proteins. RESULTS: We analyzed the evolution of functional regions of EBOV and highlight the function of conserved residues in protein activities...
September 21, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27609358/exposure-of-sexually-inactive-males-to-estrogenized-females-increased-the-investigative-and-consummatory-sexual-behavior
#15
J M Guillén-Muñoz, C A Meza-Herrera, Z Santos-Jimenez, R Rivas-Muñoz, J R Luna-Orozco, M Mellado, F G Véliz-Deras
Two trials were conducted to evaluate the effect of diverse socio-sexual cues upon male sexual behavior and the reproductive performance of anestrous does (AD). Trials were conducted in northern Mexico (26°N) during the natural anestrous season (Feb-Mar) with crossbred dairy bucks. In Experiment 1, sexually inactive bucks (SIB, n=12) were randomly allotted to three groups, four males/group: a) DEE 9novelty stimulation) - daily exchange of estrogenized females (EF) 12&12h, b) NEE (no novelty stimulation) - no-exchange of EF, 24h, or c) CON (saline-treated_ -daily exchange of AF 12&12h...
October 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27574507/visual-sexual-stimuli-cue-or-reward-a-perspective-for-interpreting-brain-imaging-findings-on-human-sexual-behaviors
#16
Mateusz Gola, Małgorzata Wordecha, Artur Marchewka, Guillaume Sescousse
There is an increasing number of neuroimaging studies using visual sexual stimuli (VSS), especially within the emerging field of research on compulsive sexual behaviors (CSB). A central question in this field is whether behaviors such as excessive pornography consumption share common brain mechanisms with widely studied substance and behavioral addictions. Depending on how VSS are conceptualized, different predictions can be formulated within the frameworks of Reinforcement Learning or Incentive Salience Theory, where a crucial distinction is made between conditioned and unconditioned stimuli (related to reward anticipation vs...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27549748/structure-and-variation-of-the-fringillidae-aves-passeriformes-mitochondrial-dna-control-region-and-their-phylogenetic-relationship
#17
Zuhao Huang, Yamin Shen, Yurong Ma
The control region is the major noncoding segment of animal mitochondrial DNA. To infer the structure and variation of Fringillidae mitochondrial DNA control region, the entire control region sequences of 25 species were analyzed. The length of the control region sequences was very conserved (1230 ± 18) and can be separated into three domains. The frequency of both substitutions and gaps was highest in the third domain and lowest in the central region. The control region has the same flanking gene order from tRNA(Glu) to tRNA(Phe)...
August 23, 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/27536223/compulsivity-across-the-pathological-misuse-of-drug-and-non-drug-rewards
#18
Paula Banca, Neil A Harrison, Valerie Voon
Behavioral adaptation is required for the successful navigation of a constantly changing environment. Impairments in behavioral flexibility are commonly observed in psychiatric disorders including those of addiction. This study investigates two distinct facets of compulsivity, namely reversal learning and attentional set shifting, implicating orbitofrontal and lateral prefrontal regions respectively, across disorders of primary and secondary rewards. Obese subjects with and without binge eating disorder (BED), individuals with compulsive sexual behaviors (CSB), alcohol dependence (AD) and pathological video-gaming (VG) were tested with two computerized tasks: the probabilistic reversal task (trials to criterion and win-stay/lose-shift errors) and the intra/extra-dimensional set shift task (IED)...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27524647/retroactivity-effects-dependency-on-the-transcription-factors-binding-mechanisms
#19
Libertad Pantoja-Hernández, Elena Álvarez-Buylla, Carlos F Aguilar-Ibáñez, Adriana Garay-Arroyo, Alberto Soria-López, Juan Carlos Martínez-García
Downstream connection effects on transcription are caused by retroactivity. When biomolecular dynamical systems interconnect retroactivity is a property that becomes important. The biological functional meaning of these effects is increasingly becoming an area of interest. Downstream targets, which are operator binding sites in transcriptional networks, may induce behaviors such as ultrasensitive responses or even represent an undesired issue in regulation. To the best of our knowledge, the role of the binding mechanisms of transcription factors in relation to minimizing - or enhancing - retroactivity effects has not been previously addressed...
August 11, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27507608/cockayne-syndrome-clinical-features-model-systems-and-pathways
#20
Ajoy C Karikkineth, Morten Scheibye-Knudsen, Elayne Fivenson, Deborah L Croteau, Vilhelm A Bohr
Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features including cachectic dwarfism, severe neurological manifestations including microcephaly and cognitive deficits, pigmentary retinopathy, cataracts, sensorineural deafness, and ambulatory and feeding difficulties, leading to death by 12 years of age on average. It is an autosomal recessive disorder, with a prevalence of approximately 2.5 per million. There are several phenotypes (1-3) and two complementation groups (CSA and CSB), and CS overlaps with xeroderma pigmentosum (XP)...
August 6, 2016: Ageing Research Reviews
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