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https://www.readbyqxmd.com/read/28427400/monitoring-mandibular-movements-to-detect-cheyne-stokes-breathing
#1
Jean-Benoît Martinot, Jean-Christian Borel, Nhat-Nam Le-Dong, Hervé Jean-Pierre Guénard, Valerie Cuthbert, Philip E Silkoff, David Gozal, Jean-Louis Pepin
BACKGROUND: The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with "sharp" large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by periodic abnormal MM patterns. The present study aims to evaluate prospectively the concordance between CSB detected by periodic MM and polysomnography (PSG) as gold-standard. The present study aims to evaluate prospectively the concordance between CSB detected by periodic MM and polysomnography (PSG) as gold-standard...
April 20, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28420125/bioavailable-citrus-sinensis-extract-polyphenolic-composition-and-biological-activity
#2
Giacomo Pepe, Francesco Pagano, Simona Adesso, Eduardo Sommella, Carmine Ostacolo, Michele Manfra, Marcello Chieppa, Marina Sala, Mariateresa Russo, Stefania Marzocco, Pietro Campiglia
Citrus plants contain large amounts of flavonoids with beneficial effects on human health. In the present study, the antioxidant and anti-inflammatory potential of bioavailable polyphenols from Citrus sinensis was evaluated in vitro and ex vivo, using the murine macrophages cell line J774A.1 and primary peritoneal macrophages. Following simulated gastro-intestinal digestion, the in vitro bioavailability of Citrus sinensis polyphenolic extract was assessed using the human cell line Caco-2 grown as monolayers on a transwell membrane...
April 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28406418/collective-poisoning-from-sea-turtle-consumption-in-mahajanga-madagascar-may-2014
#3
N G Rasamimanana, Z Z Andrianirina, F M F Razafilalaina, L M P Rakotozanany, N C Andriamalala, D Andrianarimanana, D O Tiandaza, N E Raveloson
Poisoning from eating sea turtles, medically known as chelonitoxism, is seen especially in coastal areas. It remains a public health problem in Madagascar, despite a ban on hunting these animals. The objective of this study was to describe its epidemiological and clinical aspects and outcome to improve knowledge and prevention of this type of poisoning. Chelonitoxism occurred in May 2014, affecting the population in Antsanitia, a fishing village in northwest Mahajanga, Madagascar. All patients came first to the CSB I basic health center in Antsanitia and were subsequently hospitalized at the Mahajanga CHU Pzaga, 51 in the adult emergency department and 25 in the pediatrics department...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28401660/depression-anxiety-and-compulsive-sexual-behaviour-among-men-in-residential-treatment-for-substance-use-disorders-the-role-of-experiential-avoidance
#4
Meagan J Brem, Ryan C Shorey, Scott Anderson, Gregory L Stuart
Nearly one-third of individuals in treatment for substance use disorders endorse at-risk levels of compulsive sexual behaviours (CSBs). Untreated sexual compulsivity may facilitate relapse for treatment-seeking men. Previous research and theory suggest that CSBs are maintained by efforts to escape or alter negative affect (e.g., depression and anxiety). However, this hypothesis has not been examined within a sample of men in treatment for substance use disorders. In an effort to better understand CSBs within a population of men with substance use disorders, the present study is the first to examine experiential avoidance as one potential mechanism underlying the relation between men's symptoms of depression and anxiety and their use of CSBs...
April 11, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28388663/vinculin-association-with-actin-cytoskeleton-is-necessary-for-stiffness-dependent-regulation-of-vinculin-behavior
#5
Tomohiro Omachi, Takafumi Ichikawa, Yasuhisa Kimura, Kazumitsu Ueda, Noriyuki Kioka
The extracellular matrix (ECM) is a major regulator of cell behavior. Recent studies have indicated the importance of the physical properties of the ECM, including its stiffness, for cell migration and differentiation. Using actomyosin-generated forces, cells pull the ECM and sense stiffness via cell-ECM adhesion structures called focal adhesions (FAs). Vinculin, an actin-binding FA protein, has emerged as a major player in FA-mediated mechanotransduction. Although vinculin is important for sensing ECM stiffness, the role of vinculin binding to actin in the ECM stiffness-mediated regulation of vinculin behavior remains unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28380355/dgcr8-mediates-repair-of-uv-induced-dna-damage-independently-of-rna-processing
#6
Philamer C Calses, Kiranjit K Dhillon, Nyka Tucker, Yong Chi, Jen-Wei Huang, Masaoki Kawasumi, Paul Nghiem, Yemin Wang, Bruce E Clurman, Celine Jacquemont, Philip R Gafken, Kaoru Sugasawa, Masafumi Saijo, Toshiyasu Taniguchi
Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA lesions. Treatment with UV induced phosphorylation on serine 153 (S153) of DGCR8 in both human and murine cells. S153 phosphorylation was critical for cellular resistance to UV, the removal of UV-induced DNA lesions, and the recovery of RNA synthesis after UV exposure but not for microRNA expression...
April 4, 2017: Cell Reports
https://www.readbyqxmd.com/read/28369616/nap1l1-accelerates-activation-and-decreases-pausing-to-enhance-nucleosome-remodeling-by-csb
#7
Ju Yeon Lee, Robert J Lake, Jaewon Kirk, Vilhelm A Bohr, Hua-Ying Fan, Sungchul Hohng
Cockayne syndrome protein B (CSB) belongs to the SWI2/SNF2 ATP-dependent chromatin remodeler family, and CSB is the only ATP-dependent chromatin remodeler essential for transcription-coupled nucleotide excision DNA repair. CSB alone remodels nucleosomes ∼10-fold slower than the ACF remodeling complex. Strikingly, NAP1-like histone chaperones interact with CSB and greatly enhance CSB-mediated chromatin remodeling. While chromatin remodeling by CSB and NAP1-like proteins is crucial for efficient transcription-coupled DNA repair, the mechanism by which NAP1-like proteins enhance chromatin remodeling by CSB remains unknown...
March 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28292928/cockayne-syndrome-b-protein-regulates-recruitment-of-the-elongin-a-ubiquitin-ligase-to-sites-of-dna-damage
#8
Juston C Weems, Brian D Slaughter, Jay R Unruh, Stefan Boeing, Shawn M Hall, Merry B McLaird, Takashi Yasukawa, Teijiro Aso, Jesper Q Svejstrup, Joan W Conaway, Ronald C Conaway
Elongin A performs dual functions as the transcriptionally active subunit of RNA polymerase II (Pol II) elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that ubiquitylates Pol II in response to DNA damage. Assembly of the Elongin A ubiquitin ligase and its recruitment to sites of DNA damage is a tightly regulated process induced by DNA-damaging agents and α-amanitin, a drug that induces Pol II stalling. In this study, we demonstrate (i) that Elongin A and the ubiquitin ligase subunit CUL5 associate in cells with the Cockayne syndrome B (CSB) protein and (ii) that this interaction is also induced by DNA-damaging agents and α-amanitin...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28253359/csb-ablation-induced-apoptosis-is-mediated-by-increased-endoplasmic-reticulum-stress-response
#9
Manuela Caputo, Alessio Balzerano, Ivan Arisi, Mara D'Onofrio, Rossella Brandi, Silvia Bongiorni, Stefano Brancorsini, Mattia Frontini, Luca Proietti-De-Santis
The DNA repair protein Cockayne syndrome group B (CSB) has been recently identified as a promising anticancer target. Suppression, by antisense technology, of this protein causes devastating effects on tumor cells viability, through a massive induction of apoptosis, while being non-toxic to non-transformed cells. To gain insights into the mechanisms underlying the pro-apoptotic effects observed after CSB ablation, global gene expression patterns were determined, to identify genes that were significantly differentially regulated as a function of CSB expression...
2017: PloS One
https://www.readbyqxmd.com/read/28224054/variant-profiling-of-evolving-prokaryotic-populations
#10
Markus Zojer, Lisa N Schuster, Frederik Schulz, Alexander Pfundner, Matthias Horn, Thomas Rattei
Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments and clinical diagnostics, and occurs as micro-diversity of natural habitats. The challenge for genome research is to accurately capture this heterogeneity with the currently used short sequencing reads. Recent advances in NGS technologies improved the speed and coverage and thus allowed for deep sequencing of bacterial populations. This facilitates the quantitative assessment of genomic heterogeneity, including low frequency alleles or haplotypes...
2017: PeerJ
https://www.readbyqxmd.com/read/28219707/22-azidosalvinorin-a-exhibits-antidepressant-like-effect-in-mice
#11
James Oluwagbamigbe Fajemiroye, Polepally Reddy Prabhakar, Luiz Carlos da Cunha, Elson Alves Costa, Jordan K Zjawiony
The increasing cases of depression has made the searches for new drugs and understanding of the underligning neurobiology of this psychiatric disorder a necessity. Here, we modified the structure of salvinorin A (a known halucinogen) and investigated antidepressant-like activity of its four derivatives; 22-methylsulfanylsalvinorin A(SA1), 2-O-cinnamoylsalvinorin B (CSB), 22-azidosalvinorin A (SA2), and 2-O-(4(')-azidophenylsulfonyl)salvinorin B (SA3). Prior to behavioural tests (Irwin test, open field test - OFT, forced swimming test - FST and tail suspension test - TST), SA1 was prepared by reacting salvinorin B and methylthioacetic acid with 89% yield; CSB was obtained from the reaction of salvinorin B and cinnamic acid with 92% yield; SA2 was obtained from the reaction of salvinorin B and azidoacetic acid with 81% yield; and SA3 was prepared by reacting salvinorin B with 4-azidophenylsulfonyl chloride with 80% yield...
April 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28185557/reconstruction-of-ancestral-rna-sequences-under-multiple-structural-constraints
#12
Olivier Tremblay-Savard, Vladimir Reinharz, Jérôme Waldispühl
BACKGROUND: Secondary structures form the scaffold of multiple sequence alignment of non-coding RNA (ncRNA) families. An accurate reconstruction of ancestral ncRNAs must use this structural signal. However, the inference of ancestors of a single ncRNA family with a single consensus structure may bias the results towards sequences with high affinity to this structure, which are far from the true ancestors. METHODS: In this paper, we introduce achARNement, a maximum parsimony approach that, given two alignments of homologous ncRNA families with consensus secondary structures and a phylogenetic tree, simultaneously calculates ancestral RNA sequences for these two families...
November 11, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28164788/variations-in-the-bacterial-community-compositions-at-different-sites-in-the-tomb-of-emperor-yang-of-the-sui-dynasty
#13
Zhi Huang, Fei Zhao, Yonghui Li, Jianwei Zhang, Youzhi Feng
To fully understand the bacterial processes in tomb environments, it is necessary to investigate the details of the bacterial communities present under such oligotrophic conditions. Here, high-throughput sequencing based on partial 16S rRNA gene sequences was used to fully evaluate the bacterial communities at different sites in the tomb of Emperor Yang of the Sui Dynasty. We also aimed to identify the soil factors that were significant related to bacterial diversity and community composition. The results showed the presence of a broad taxonomic diversity that included nine major phyla...
March 2017: Microbiological Research
https://www.readbyqxmd.com/read/28112852/investigation-of-the-er-yag-laser-and-diamond-bur-cavity-preparation-on-the-marginal-microleakage-of-class-v-cavities-restored-with-different-flowable-composites
#14
Elif Bahar Tuna, Emre Ozel, Yelda Kasimoglu, Erhan Firatli
The purpose of this study was to evaluate the efficiency of the Er:YAG laser and diamond bur cavity preparation on the marginal microleakage of Class V cavities. Group 1: bur preparation (bp) + Vertise Flow (VF); Group 2: laser preparation (lp) + VF; Group 3: bp + Adper Easy One (AEO) + Filtek Ultimate Flowable Composite (FUFC); Group 4: lp + AEO + FUFC; Group 5: bp + Clearfil S3 Bond (CSB) + Clearfil Majesty Flow (CMF); Group 6: lp + CSB + CMF. Data were analyzed by Kruskal-Wallis and Mann-Whitney U tests (p < ...
January 23, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28095775/ara-peps-a-repository-of-putative-sorf-encoded-peptides-in-arabidopsis-thaliana
#15
Rashmi R Hazarika, Barbara De Coninck, Lidia R Yamamoto, Laura R Martin, Bruno P A Cammue, Vera van Noort
BACKGROUND: Many eukaryotic RNAs have been considered non-coding as they only contain short open reading frames (sORFs). However, there is increasing evidence for the translation of these sORFs into bioactive peptides with potent signaling, antimicrobial, developmental, antioxidant roles etc. Yet only a few peptides encoded by sORFs are annotated in the model organism Arabidopsis thaliana. RESULTS: To aid the functional annotation of these peptides, we have developed ARA-PEPs (available at http://www...
January 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28081252/corn-soy-blend-fortified-with-phosphorus-to-prevent-refeeding-hypophosphatemia-in-undernourished-piglets
#16
Anne-Louise Hother, Mikkel Lykke, Torben Martinussen, Hanne Damgaard Poulsen, Christian Mølgaard, Per Torp Sangild, André Briend, Christian Fink Hansen, Henrik Friis, Kim F Michaelsen, Thomas Thymann
BACKGROUND: Phosphorus (P) levels in refeeding diets are very important as undernourished children are at risk of hypophosphatemia during refeeding. For this reason, conventional corn-soy-blends (CSB) have been reformulated by the World Food Programme to obtain a mono-calcium-phosphate fortified product (CSB+) and a product further fortified with skim milk powder (CBS++). METHODS: Using a piglet model of undernourished children, we hypothesized that feeding of CSB+, CSB++ or CSB+ with added whey permeate (CSB+/wp) would help to prevent refeeding hypophosphatemia...
2017: PloS One
https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#17
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067596/comparative-analysis-of-the-complete-mitochondrial-genomes-of-three-geographical-topmouth-culter-culter-alburnus-groups-and-implications-for-their-phylogenetics
#18
COMPARATIVE STUDY
Jianwu Shi, Dexia Wang, Junhua Wang, Junqing Sheng, Kou Peng, Beijuan Hu, Liugen Zeng, Minghe Xiao, Yijiang Hong
Topmouth culter (C. alburnus) is an important commercial fish in China. We compared the nucleotide variations in the mtDNA genomes among three geographical groups of Culter alburnus: Liangzi Lake, Hubei Province (referred to as LZH); Taihu Lake, Jiangsu Province (TH); and Poyang Lake, Jiangxi Province (PYH). The similarity of whole mtDNA genomes ranged from 0.992 to 0.999. The similarity among 13 protein-coding genes, 2 rRNA genes, and the D-loop sequences was found to range from 0.982 to 0.996. This is useful data for future designing work for making specific molecular marker for distinguishing individuals of C...
March 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28050982/effect-of-tannic-acid-on-bond-strength-of-etch-and-rinse-and-self-etch-adhesive-systems-in-dentin-of-primary-teeth
#19
Masoumeh Ebrahimi, Alireza Sarraf Shirazi, Faraneh Abdolhoseinpour, Mojtaba Abdollahi
INTRODUCTION: One of the possible mechanisms for the gradual destruction of bond strength in dentin-resin interface, could be due to the demineralized unstable collagen matrix. Use of protease inhibitors, such as tannic acid (TA) could prevent destruction of collagen fibers. The aim of this study was to compare the TA effect on bond strength of etch and rinse and self-etch adhesive systems in the dentin of primary teeth. MATERIALS AND METHODS: This in vitro study was done on 40 extracted primary molar teeth...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28040160/isolation-molecular-and-phenotypic-characterization-and-antibiotic-susceptibility-of-cronobacter-spp-from-brazilian-retail-foods
#20
Marcelo Luiz Lima Brandão, Natália Scudeller Umeda, Emily Jackson, Stephen James Forsythe, Ivano de Filippis
Several Cronobacter species are opportunistic pathogens that cause infections in humans. The aim of this study was to detect Cronobacter spp. from 90 samples of retail foods in Brazil, and characterize the strains by phenotypic tests, molecular assays and antibiotic susceptibility. Three isolation methodologies were evaluated using different selective enrichments and the isolates were identified using Vitek 2.0, PCRs protocols, fusA allele sequencing and multilocus sequence typing (MLST). Thirty-eight samples (42...
May 2017: Food Microbiology
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