Friederike Ebner, Katja Lindner, Katharina Janek, Agathe Niewienda, Piotr H Malecki, Manfred S Weiss, Tara E Sutherland, Arnd Heuser, Anja A Kühl, Jürgen Zentek, Andreas Hofmann, Susanne Hartmann
Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. Here, we aimed to identify the proteins accounting for the modulatory effects of the T. suis L1 ES proteins and studied six selected T. suis L1 proteins for their immunomodulatory efficacy in a murine OVA-induced allergic airway disease model. In particular, an enzymatically active T. suis chitinase mediated amelioration of clinical signs of airway hyperreactivity, primarily associated with suppression of eosinophil recruitment into the lung, the associated chemokines, and increased numbers of RELM α + interstitial lung macrophages...
2021: Journal of Immunology Research