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Trichuris suis

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https://www.readbyqxmd.com/read/29279080/corrigendum-to-profiling-circulating-mirnas-in-serum-from-pigs-infected-with-the-porcine-whipworm-trichuris-suis-vet-parasitol-223-2016-30-33
#1
Eline Palm Hansen, Helene Kringel, Stig Milan Thamsborg, Aaron Jex, Peter Nejsum
No abstract text is available yet for this article.
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29184071/preventive-trichuris-suis-ova-tso-treatment-protects-immunocompetent-rabbits-from-dss-colitis-but-may-be-detrimental-under-conditions-of-immunosuppression
#2
Irina Leonardi, Alexandra Gerstgrasser, Thomas S B Schmidt, Flora Nicholls, Bernhard Tewes, Roland Greinwald, Christian von Mering, Gerhard Rogler, Isabelle Frey-Wagner
Trichuris suis ova (TSO) have been tested for therapeutic application in inflammatory bowel diseases (IBD) yet understanding of the underlying mechanisms and safety in an immunocompromised host is limited due to lack of a suitable animal model. We used a recently established rabbit model of dextran sodium sulphate (DSS) induced colitis to study the efficacy, mechanisms and safety of TSO therapy in immunocompetent and immunosuppressed animals. TSO treatment prevented the DSS induced weight loss, delayed the onset of DSS induced symptoms by 2 days and significantly reduced the disease activity (DAI)...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29179075/manure-management-and-public-health-sanitary-and-socio-economic-aspects-among-urban-livestock-keepers-in-cambodia
#3
Gunilla Ström, Ann Albihn, Tomas Jinnerot, Sofia Boqvist, Agnes Andersson-Djurfeldt, Seng Sokerya, Kristina Osbjer, Sorn San, Holl Davun, Ulf Magnusson
Livestock manure is a valuable source of nutrients for crop production, but can also pose a public health hazard and have negative environmental impacts. This study investigated manure management practices among urban and peri-urban livestock keepers in Cambodia, to identify risk behaviours and socio-economic aspects associated with the handling of manure. A survey including 204 households was conducted, using a structured questionnaire with questions on demographics, socio-economic characteristics and household practices related to manure management...
November 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29165218/molecular-identification-of-trichuris-suis-and-trichuris-trichiura-eggs-in-human-populations-from-thailand-lao-pdr-and-myanmar
#4
Issarapong Phosuk, Oranuch Sanpool, Tongjit Thanchomnang, Lakkhana Sadaow, Rutchanee Rodpai, Witthaya Anamnart, Penchom Janwan, Adulsak Wijit, Sakhone Laymanivong, Win Pa Pa Aung, Pewpan M Intapan, Wanchai Maleewong
Trichuris trichiura is a soil-transmitted helminth infecting human populations globally. Human cases caused by Trichuris suis and Trichuris vulpis have also been reported. Molecular identifications of Trichuris species infecting human populations in Lao PDR and Myanmar are lacking. Here, we explored molecular data obtained from Trichuris eggs recovered from human fecal samples from these countries and compared these with new and existing data from Thailand. Nuclear ribosomal DNA (18S and ITS2) sequences were amplified from Trichuris eggs and sequenced...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29156431/pathway-of-oxfendazole-from-the-host-into-the-worm-trichuris-suis-in-pigs
#5
Tina V A Hansen, Andrew R Williams, Matthew Denwood, Peter Nejsum, Stig M Thamsborg, Christian Friis
It is well known that the efficacy of a single oral dose of benzimidazoles against Trichuris spp. infections in humans and animals is poor, but is currently still used in control programmes against human trichuriasis. However, the route of the benzimidazoles from the treated host to Trichuris remains unknown. As parts of adult Trichuris are situated intracellularly in the caecum, they might be exposed to anthelmintic drugs in the intestinal content as well as the mucosa. In this study, the pathway of oxfendazole and its metabolites was explored using a T...
November 9, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29064315/safety-and-efficacy-of-helminth-treatment-in-relapsing-remitting-multiple-sclerosis-results-of-the-hint-2-clinical-trial
#6
John Fleming, Gianna Hernandez, Leslie Hartman, Jane Maksimovic, Sara Nace, Benjamin Lawler, Todd Risa, Thomas Cook, Rashmi Agni, Mark Reichelderfer, Christopher Luzzio, Loren Rolak, Aaron Field, Zsuzsanna Fabry
BACKGROUND: The hygiene hypothesis suggests that microbial replacement may be therapeutic in allergic and autoimmune diseases. Nevertheless, the results of helminth treatment, including in multiple sclerosis (MS), have been inconclusive. OBJECTIVE: To assess safety and brain magnetic resonance imaging (MRI) activity in subjects with relapsing-remitting multiple sclerosis (RRMS) during oral administration of ova from the porcine whipworm, Trichuris suis (TSO). METHODS: A total of 16 disease-modifying treatment (DMT) naive RRMS subjects were studied in a baseline versus treatment (BVT) controlled prospective study...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28694301/helminth-antigens-counteract-a-rapid-high-fat-diet-induced-decrease-in-adipose-tissue-eosinophils
#7
Susan M van den Berg, Andrea D van Dam, Pascal J H Kusters, Linda Beckers, Myrthe den Toom, Saskia van der Velden, Jan Van den Bossche, Irma van Die, Mariëtte R Boon, Patrick C N Rensen, Esther Lutgens, Menno P J de Winther
Brown adipose tissue (BAT) activation and white adipose tissue (WAT) beiging can increase energy expenditure and have the potential to reduce obesity and associated diseases. The immune system is a potential target in mediating brown and beige adipocyte activation. Type 2 and anti-inflammatory immune cells contribute to metabolic homeostasis within lean WAT, with a prominent role for eosinophils and interleukin (IL)-4-induced anti-inflammatory macrophages. We determined eosinophil numbers in epididymal WAT (EpAT), subcutaneous WAT (ScAT) and BAT after 1 day, 3 days or 1 week of high-fat diet (HFD) feeding in C57Bl/6 mice...
October 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28664463/therapeutic-potential-of-helminths-in-autoimmune-diseases-helminth-derived-immune-regulators-and-immune-balance
#8
REVIEW
Meng Wang, Linxiang Wu, Rennan Weng, Weihong Zheng, Zhongdao Wu, Zhiyue Lv
Helminths have accompanied human throughout history by releasing immune-evasion molecules that could counteract an aberrant immune response within the host. In the past decades, helminth infections are becoming less prevalent possibly due to the developed sanitation. Meanwhile, the incidence of autoimmune diseases is increasing, which cannot be exclusively explained by the changes of susceptibility genes. While the hygiene hypothesis casts light on the problem. The infections of helminths are believed to interact with and regulate human immunity with the byproduct of suppressing the autoimmune diseases...
August 2017: Parasitology Research
https://www.readbyqxmd.com/read/28606697/whipworm-kinomes-reflect-a-unique-biology-and-adaptation-to-the-host-animal
#9
Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Bill C H Chang, Peter Nejsum, Edoardo Pozio, Giuseppe La Rosa, Paul W Sternberg, Robin B Gasser
Roundworms belong to a diverse phylum (Nematoda) which is comprised of many parasitic species including whipworms (genus Trichuris). These worms have adapted to a biological niche within the host and exhibit unique morphological characteristics compared with other nematodes. Although these adaptations are known, the underlying molecular mechanisms remain elusive. The availability of genomes and transcriptomes of some whipworms now enables detailed studies of their molecular biology. Here, we defined and curated the full complement of an important class of enzymes, the protein kinases (kinomes) of two species of Trichuris, using an advanced and integrated bioinformatic pipeline...
November 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28602842/immune-responses-and-parasitological-observations-induced-during-probiotic-treatment-with-medicinal-trichuris-suis-ova-in-a-healthy-volunteer
#10
Andrew R Williams, Anders Dige, Tue Kruse Rasmussen, Christian L Hvas, Jens F Dahlerup, Lars Iversen, C Rune Stensvold, Jørgen Agnholt, Peter Nejsum
Ingestion of eggs (ova) of the porcine nematode parasite Trichuris suis (TSO) may reduce the severity of autoimmune disorders, however the development of TSO treatment as a useful therapy for autoimmune diseases is hampered by a lack of knowledge on the development of the parasite and the nature of the local immune responses in humans. Here, we used colonoscopy to investigate the development of T. suis and related mucosal and systemic immune responses during TSO treatment in an intestinally healthy male volunteer...
August 2017: Immunology Letters
https://www.readbyqxmd.com/read/28392468/description-of-a-new-species-trichuris-ursinus-n-sp-nematoda-trichuridae-from-papio-ursinus-keer-1792-from-south-africa
#11
Rocío Callejón, Ali Halajian, Cristina Cutillas
In the present work, we carried out a morphological, biometrical and molecular study of whipworms Trichuris Roederer, 1761 (Nematoda: Trichuridae) parasitizing Papio ursinus Keer 1792 (Chacma baboon). Biometrical and molecular data suggest a new species of Trichuris parasitizing baboons. In addition of main morphological features (spicule, spicule sheath, spicule tube, proximal cloacal tube, distal cloacal tube, vulva, vagina), the mean values of individual variables between Trichuris colobae, Trichuris suis, Trichuris trichiura examined by Student's t tests suggest that T...
April 7, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28030334/trichuris-suis-secrete-products-that-reduce-disease-severity-in-a-multiple-sclerosis-model
#12
Christine Søholm Hansen, Henrik Hasseldam, Idahella Hyldgaard Bacher, Stig Milan Thamsborg, Flemming Fryd Johansen, Helene Kringel
Multiple sclerosis is a chronic inflammatory central nervous system (CNS) disease, which affects about 1 in 1000 individuals in the western world. It has been suggested that this relatively high prevalence is linked to a high level of hygiene, i.e. a reduced exposure to various microorganisms, including parasites. Parasites are known to employ different immunomodulatory and antiinflammatory strategies, which enable them to evade destruction by the immune system. We have investigated the immunomodulation by the swine whipworm, Trichuris suis, by measuring the impact of oral administration of T...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/27905107/co-operative-suppression-of-inflammatory-responses-in-human-dendritic-cells-by-plant-proanthocyanidins-and-products-from-the-parasitic-nematode-trichuris-suis
#13
Andrew R Williams, Elsenoor J Klaver, Lisa C Laan, Aina Ramsay, Christos Fryganas, Rolf Difborg, Helene Kringel, Jess D Reed, Irene Mueller-Harvey, Søren Skov, Irma van Die, Stig M Thamsborg
Interactions between dendritic cells (DCs) and environmental, dietary and pathogen antigens play a key role in immune homeostasis and regulation of inflammation. Dietary polyphenols such as proanthocyanidins (PAC) may reduce inflammation, and we therefore hypothesized that PAC may suppress lipopolysaccharide (LPS) -induced responses in human DCs and subsequent T helper type 1 (Th1) -type responses in naive T cells. Moreover, we proposed that, because DCs are likely to be exposed to multiple stimuli, the activity of PAC may synergise with other bioactive molecules that have anti-inflammatory activity, e...
March 2017: Immunology
https://www.readbyqxmd.com/read/27872753/multifunctional-thioredoxin-like-protein-from-the-gastrointestinal-parasitic-nematodes-strongyloides-ratti-and-trichuris-suis-affects-mucosal-homeostasis
#14
Dana Ditgen, Emmanuela M Anandarajah, Jan Hansmann, Dominic Winter, Guido Schramm, Klaus D Erttmann, Eva Liebau, Norbert W Brattig
The cellular redox state is important for the regulation of multiple functions and is essential for the maintenance of cellular homeostasis and antioxidant defense. In the excretory/secretory (E/S) products of Strongyloides ratti and Trichuris suis sequences for thioredoxin (Trx) and Trx-like protein (Trx-lp) were identified. To characterize the antioxidant Trx-lp and its interaction with the parasite's mucosal habitat, S. ratti and T. suis Trx-lps were cloned and recombinantly expressed. The primary antioxidative activity was assured by reduction of insulin and IgM...
2016: Journal of Parasitology Research
https://www.readbyqxmd.com/read/27806992/the-whipworm-trichuris-suis-secretes-prostaglandin-e2-to-suppress-proinflammatory-properties-in-human-dendritic-cells
#15
Lisa C Laan, Andrew R Williams, Kathrin Stavenhagen, Martin Giera, Gijs Kooij, Iliyan Vlasakov, Hakan Kalay, Helene Kringel, Peter Nejsum, Stig M Thamsborg, Manfred Wuhrer, Christine D Dijkstra, Richard D Cummings, Irma van Die
Clinical trials have shown that administration of the nematode Trichuris suis can be beneficial in treating various immune disorders. To provide insight into the mechanisms by which this worm suppresses inflammatory responses, an active component was purified from T. suis soluble products (TsSPs) that suppress---- TNF and IL-12 secretion from LPS-activated human dendritic cells (DCs). Analysis by liquid chromatography tandem mass spectrometry identified this compound as prostaglandin (PG)E2. The purified compound showed similar properties compared with TsSPs and commercial PGE2 in modulating LPS-induced expression of many cytokines and chemokines and in modulating Rab7B and P2RX7 expression in human DCs...
February 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27785599/prevalence-and-risk-factors-for-gastrointestinal-parasites-in-small-scale-pig-enterprises-in-central-and-eastern-uganda
#16
Kristina Roesel, Ian Dohoo, Maximilian Baumann, Michel Dione, Delia Grace, Peter-Henning Clausen
In Eastern Africa, small-scale pig keeping has emerged as a popular activity to generate additional household income. Infections of pigs with gastrointestinal helminths can limit production output, increase production costs, and pose zoonotic risks. A cross-sectional, community-based study in three districts in Eastern and Central Uganda examined the prevalence of gastrointestinal helminthes and associated risk factors in 932 randomly sampled pigs. Using the combined sedimentation-flotation method, 61.4 % (58...
January 2017: Parasitology Research
https://www.readbyqxmd.com/read/27707789/a-randomised-double-blind-placebo-controlled-trial-of-trichuris-suis-ova-in-active-crohn-s-disease
#17
RANDOMIZED CONTROLLED TRIAL
Jürgen Schölmerich, Klaus Fellermann, Frank W Seibold, Gerhard Rogler, Jost Langhorst, Stefanie Howaldt, Gottfried Novacek, Andreas Munk Petersen, Oliver Bachmann, Harald Matthes, Norbert Hesselbarth, Niels Teich, Jan Wehkamp, Jochen Klaus, Claudia Ott, Karin Dilger, Roland Greinwald, Ralph Mueller
Background and Aims: To investigate the efficacy and safety of three different dosages of embryonated, viable eggs of Trichuris suis [TSO] versus placebo for induction of remission in mildly-to-moderately active ileocolonic, uncomplicated Crohn's disease [CD]. Methods: Adults with active CD [n = 252] randomly received six fortnightly doses of 250, 2500, or 7500 TSO/15 ml suspension/day [TSO 250, TSO 2500, TSO 7500], or 15 ml placebo solution/day, in a double-blind fashion, with 4 weeks' follow-up...
April 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27639842/occurrence-clinical-involvement-and-zoonotic-potential-of-endoparasites-infecting-swiss-pigs
#18
Fabienne Schubnell, Sereina von Ah, Robert Graage, Titus Sydler, Xaver Sidler, Daniela Hadorn, Walter Basso
In order to estimate the diversity, clinical involvement and zoonotic potential of parasites in pigs submitted for diagnosis to the PathoPig project of the Swiss Federal Food Safety and Veterinary Office, faeces (n=125) from suckling piglets (n=39), weaners (n=60) and piglets beginning fattening (n=26) from 74 Swiss farms were examined by 3 coproscopical methods (i.e. sedimentation/zinc chloride-flotation; SAFC and Ziehl-Neelsen staining). Samples microscopically positive for Cryptosporidium were further tested by PCR/sequencing for species assessment...
December 2016: Parasitology International
https://www.readbyqxmd.com/read/27341742/demodex-phylloides-infection-in-swine-reared-in-a-peri-urban-family-farm-located-on-the-outskirts-of-the-metropolitan-region-of-s%C3%A3-o-paulo-brazil
#19
Josete Garcia Bersano, Márcia Cristina Mendes, Fernanda Calvo Duarte, Claudia Del Fava, Sueli Moda de Oliveira, Elizabeth Spósito Filha, Eliana Scarcelli Pinheiro, Alessandra Figueiredo de Castro Nassar, Maria Cristina de Vasconcellos Bilynskyj, Renato Akio Ogata, Paulo Henrique Selbmann Sampaio, Margareth Élide Genovez
This paper reports the occurrence of porcine demodicosis caused by the mite Demodex phylloides in hogs reared in a peri-urban family farm located in Francisco Morato, a municipality of the Metropolitan Region of São Paulo, capital city of the state of São Paulo, Brazil. In a parcel of forty Landrace - Large White cross hogs, approximately four months old, four animals presented severe skin lesions in the form of small nodules over their entire body, especially in the periocular region, snout, lower abdomen and flanks...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27240605/practices-and-outcomes-of-self-treatment-with-helminths-based-on-physicians-observations
#20
J Liu, R A Morey, J K Wilson, W Parker
The successful use of helminths as therapeutic agents to resolve inflammatory disease was first recorded 40 years ago. Subsequent work in animal models and in humans has demonstrated that the organisms might effectively treat a wide range of inflammatory diseases, including allergies, autoimmune disorders and inflammation-associated neuropsychiatric disorders. However, available information regarding the therapeutic uses and effects of helminths in humans is limited. This study probes the practices and experiences of individuals 'self-treating' with helminths through the eyes of their physicians...
May 2017: Journal of Helminthology
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