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Delayed sleep phase

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https://www.readbyqxmd.com/read/29783060/sleep-dependent-consolidation-patterns-reveal-insights-into-episodic-memory-structure
#1
Carlos N Oyanedel, Anuck Sawangjit, Jan Born, Marion Inostroza
Episodic memory formation is considered a genuinely hippocampal function. Its study in rodents has relied on two different task paradigms, i.e. the so called "what-where-when" (WW-When) task and "what-where-which" (WW-Which) task. The WW-When task aims to assess the memory for an episode as an event bound into its context defined by spatial and distinct temporal information, the WW-Which task lacks the temporal component and introduces, instead, an "occasion setter" marking the broader contextual configuration in which the event occurred...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29777288/time-shifting-effects-of-methylphenidate-on-daily-rhythms-in-the-diurnal-rodent-arvicanthis-ansorgei
#2
Jorge Mendoza, Hester C van Diepen, Rob Rodrigues Pereira, Johanna H Meijer
People suffering of attention-deficit/hyperactivity disorder (ADHD) and treated with the psychostimulant methylphenidate (MPH) show sleep-wake cycle and daily rhythm alterations despite the beneficial effects of MPH on behavioral symptoms (i.e., hyperactivity, attention). In nocturnal rodents (i.e., mice), chronic exposure to MPH alters the neural activity of the circadian clock in the suprachiasmatic nucleus (SCN), behavioral rhythms, and the sleep-wake cycle. Here, we studied the effects of MPH on daily rhythms of behavior and body temperature of the diurnal rodent Arvicanthis ansorgei...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29773213/sleep-structure-and-awakening-threshold-in-delayed-sleep-wake-phase-disorder-patients-compared-to-healthy-sleepers
#3
Brandy Solheim, Knut Langsrud, Håvard Kallestad, Morten Engstrøm, Bjørn Bjorvatn, Trond Sand
STUDY OBJECTIVES: Difficult early morning awakening is a primary symptom of delayed sleep-wake phase disorder (DSWPD), however, it remains poorly investigated. Our main objective was to quantify the awakening threshold in DSWPD-patients and healthy controls as well as investigate a possible relationship with sleep stages. A secondary objective was to compare habitual sleep measured by polysomnography and actigraphy between patients and controls. METHODS: Twenty DSWPD patients and 16 controls had two polysomnographic recordings at a sleep laboratory...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29743086/numerical-study-of-entrainment-of-the-human-circadian-system-and-recovery-by-light-treatment
#4
Soon Ho Kim, Segun Goh, Kyungreem Han, Jong Won Kim, MooYoung Choi
BACKGROUND: While the effects of light as a zeitgeber are well known, the way the effects are modulated by features of the sleep-wake system still remains to be studied in detail. METHODS: A mathematical model for disturbance and recovery of the human circadian system is presented. The model combines a circadian oscillator and a sleep-wake switch that includes the effects of orexin. By means of simulations, we characterize the period-locking zone of the model, where a stable 24-hour circadian rhythm exists, and the occurrence of circadian disruption due to both insufficient light and imbalance in orexin...
May 9, 2018: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29735673/simulated-night-shift-work-induces-circadian-misalignment-of-the-human-peripheral-blood-mononuclear-cell-transcriptome
#5
Laura Kervezee, Marc Cuesta, Nicolas Cermakian, Diane B Boivin
Misalignment of the endogenous circadian timing system leads to disruption of physiological rhythms and may contribute to the development of the deleterious health effects associated with night shift work. However, the molecular underpinnings remain to be elucidated. Here, we investigated the effect of a 4-day simulated night shift work protocol on the circadian regulation of the human transcriptome. Repeated blood samples were collected over two 24-hour measurement periods from eight healthy subjects under highly controlled laboratory conditions before and 4 days after a 10-hour delay of their habitual sleep period...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29727473/can-circadian-dysregulation-exacerbate-migraines
#6
REVIEW
Jason C Ong, Hannah L Taylor, Margaret Park, Helen J Burgess, Rina S Fox, Sarah Snyder, Jeanetta C Rains, Colin A Espie, James K Wyatt
OBJECTIVE: This observational pilot study examined objective circadian phase and sleep timing in chronic migraine (CM) and healthy controls (HC) and the impact of circadian factors on migraine frequency and severity. BACKGROUND: Sleep disturbance has been identified as a risk factor in the development and maintenance of CM but the biological mechanisms linking sleep and migraine remain largely theoretical. METHODS: Twenty women with CM and 20 age-matched HC completed a protocol that included a 7 day sleep assessment at home using wrist actigraphy followed by a circadian phase assessment using salivary melatonin...
May 4, 2018: Headache
https://www.readbyqxmd.com/read/29680419/a-randomised-controlled-trial-of-bright-light-therapy-and-morning-activity-for-adolescents-and-young-adults-with-delayed-sleep-wake-phase-disorder
#7
C Richardson, N Cain, K Bartel, G Micic, B Maddock, M Gradisar
A randomised controlled trial evaluated bright light therapy and morning activity for the treatment of Delayed Sleep-Wake Phase Disorder (DSWPD) in young people. 60 adolescents and young adults (range = 13-24 years, mean = 15.9 ± 2.2 y, 63% f) diagnosed with DSWPD were randomised to receive three weeks of post-awakening Green Bright Light Therapy (∼507 nm) and Sedentary Activity (sitting, watching TV), Green Bright Light Therapy and Morning Activity (standing, playing motion-sensing videogame), Red Light Therapy (∼643 nm) and Sedentary Activity or Red Light Therapy and Morning Activity...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29660304/circadian-rhythm-resynchronization-improved-isoflurane-induced-cognitive-dysfunction-in-aged-mice
#8
Jia Song, Shuaishuai Chu, Yin Cui, Yue Qian, Xiuxiu Li, Fangxia Xu, Xueming Shao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Postoperative cognitive dysfunction (POCD) is a common clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery. Advanced age is a significant independent risk factor for POCD. We previously reported that in young mice, sleep-wake rhythm is involved in the isoflurane-induced memory impairment. In present study, we sought to determine whether advanced age increased the risk of POCD through aggravated and prolonged post-anesthetic circadian disruption in the elderly. We constructed POCD model by submitting the mice to 5-h 1...
April 13, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29609703/diagnostic-and-treatment-challenges-of-sighted-non-24-hour-sleep-wake-disorder
#9
Roneil G Malkani, Sabra M Abbott, Kathryn J Reid, Phyllis C Zee
STUDY OBJECTIVES: To report the diagnostic and treatment challenges of sighted non-24-hour sleep-wake disorder (N24SWD). METHODS: We report a series of seven sighted patients with N24SWD clinically evaluated by history and sleep diaries, and when available wrist actigraphy and salivary melatonin levels, and treated with timed melatonin and bright light therapy. RESULTS: Most patients had a history of a delayed sleep-wake pattern prior to developing N24SWD...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29607311/shiftwork-mediated-disruptions-of-circadian-rhythms-and-sleep-homeostasis-cause-serious-health-problems
#10
REVIEW
Suliman Khan, Pengfei Duan, Lunguang Yao, Hongwei Hou
Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29555485/cognitive-performance-in-adolescents-with-delayed-sleep-wake-phase-disorder-treatment-effects-and-a-comparison-with-good-sleepers
#11
C Richardson, G Micic, N Cain, K Bartel, B Maddock, M Gradisar
The present study aimed to investigate whether Australian adolescents with Delayed Sleep-Wake Phase Disorder have impaired cognitive performance and whether chronobiological treatment for Delayed Sleep-Wake Phase Disorder improves adolescents' sleep, daytime functioning and cognitive performance. Adolescents with Delayed Sleep-Wake Phase Disorder (mean = 15.68 ± 2.1 y, 62% f) reported significantly later sleep timing (d = 1.03-1.45), less total sleep time (d = 0.82) and greater daytime sleepiness (d = 2...
March 16, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29551602/a-more-generalized-fear-response-after-a-daytime-nap
#12
Per Davidson, Ingegerd Carlsson, Peter Jönsson, Mikael Johansson
The aim of this study was to examine how a daytime nap affected the consolidation of fear learning. Participants first underwent fear conditioning during which they were exposed to a large and a small circle. One of these was repeatedly paired with an electric shock (making it the CS+), whereas the other circle was never paired with the shock (the CS-). After a delay interval containing either a nap or wake, participants again viewed the CS+ and the CS- intermixed with eight novel circles that varied in size between the two stimuli seen before, as well as a blue triangle that served as a novel stimulus without prior fear relevance...
May 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29534856/delayed-sleep-phase-syndrome-and-bipolar-disorder-pathogenesis-and-available-common-biomarkers
#13
REVIEW
Farid Talih, Nour Y Gebara, Farah S Andary, Stefania Mondello, Firas Kobeissy, Raffaele Ferri
Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions...
February 13, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29529448/a-case-control-study-of-sleep-disturbances-in-pediatric-obsessive-compulsive-disorder
#14
Fern Jaspers-Fayer, Sarah Yao Lin, Laura Belschner, Janet Mah, Elaine Chan, Clare Bleakley, Rhonda Ellwyn, Annie Simpson, Katherine McKenney, S Evelyn Stewart
BACKGROUND: Sleep disturbances, including delayed sleep phase disorder (DSPD) and disorders of sleep initiation and maintenance (DIMS), have repeatedly been identified in adult obsessive-compulsive disorder (OCD). These disturbances have not been well-characterized objectively in pediatric OCD. METHODS: Thirty OCD-affected youth (8-18 yrs, 40% male) and 30 age and gender-matched healthy controls (HCs) completed the Sleep Disturbances Scale for Children (SDSC), and one week of continuous actigraphy with concurrent sleep diary documentation...
April 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29522222/altered-diurnal-states-in-insomnia-reflect-peripheral-hyperarousal-and-metabolic-desynchrony-a-preliminary-study
#15
Philip Gehrman, Arjun Sengupta, Elizabeth Harders, Er Ubeydullah, Allan I Pack, Aalim Weljie
Study Objectives: Insomnia is a common sleep disorder that is associated with a range of adverse outcomes. Patients with insomnia exhibit hyperarousal in multiple domains, including an elevated metabolic rate, but specific metabolic molecular perturbations are unknown. Furthermore, objective clinical markers of insomnia are not available and current assessment of pathological extent relies on self-report. Here, we provide preliminary evidence that chronic insomnia is remarkably reflected in the periphery through detailed metabolic assessments...
May 1, 2018: Sleep
https://www.readbyqxmd.com/read/29463186/daily-profiles-of-light-exposure-and-evening-use-of-light-emitting-devices-in-young-adults-complaining-of-a-delayed-sleep-schedule
#16
Solenne Van der Maren, Christophe Moderie, Catherine Duclos, Jean Paquet, Véronique Daneault, Marie Dumont
A number of factors can contribute to a delayed sleep schedule. An important factor could be a daily profile of light exposure favoring a later circadian phase. This study aimed to compare light exposure between 14 young adults complaining of a delayed sleep schedule and 14 matched controls and to identify possible associations between habitual light exposure and circadian phase. Exposure to white and blue light was recorded with ambulatory monitors for 7 consecutive days. Participants also noted their daily use of light-emitting devices before bedtime...
April 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29445534/delayed-sleep-wake-phase-disorder
#17
REVIEW
Alexander D Nesbitt
Delayed sleep-wake phase disorder (DSWPD) is the most commonly encountered of the circadian rhythm sleep-wake disorders (CRSDs), and is often confused with sleep initiation insomnia. It typically emerges in teenage years and persists into adulthood. In essence, people with the disorder have an abnormally delayed major sleep episode relative to the dark phase of the solar cycle, and hence great difficulty initiating sleep at an appropriately early time, and, as a knock-on effect, waking at a desirable time in the morning, leading to chronic, and often quite severe sleep restriction trying to conform to a 9 to 5 schedule...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29425580/japanese-sleep-questionnaire-for-elementary-schoolers-jsq-es-validation-and-population-based-score-distribution
#18
Ayano Kuwada, Ikuko Mohri, Ryosuke Asano, Shigeyuki Matsuzawa, Kumi Kato-Nishimura, Ikuko Hirata, Takashi Mitsuhosi, Kuriko Kagitani-Shimono, Mariko Nakanishi, Masaya Tachibana, Yuko Ohno, Masako Taniike
OBJECTIVE: The Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES) was developed to measure the sleep habits and disturbances of Japanese children. The current study aimed to present psychometric properties and describe the score distribution of the JSQ-ES. In addition, it examined correlations between the sleep and daytime behavior of school-aged children. METHOD: Guardians of 4369 elementary school children and 100 children diagnosed with sleep disorders in two clinics completed the JSQ-ES...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29381486/effect-of-a-quality-improvement-project-to-reduce-noise-in-a-pediatric-unit
#19
Maher Soubra, Yara Abou Harb, Sara Hatoum, Nadine Yazbeck, Mirna Khoury, Elie Bou Mansour, Lina Kurdahi Badr
PURPOSE: Noise levels remain high in clinical settings, which may result in stress and sleep disruption, and can lead to immunosuppression, delayed healing, confusion, disorientation, delusions, and increased length of hospital stay. The purpose of this quality improvement project was to assess effects of a multidisciplinary noise reduction program on a pediatric unit in an acute care hospital in a developing country. METHODS: A quality improvement project was carried out over 15 months in a pediatric unit...
March 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29373120/impact-of-sleep-and-circadian-rhythms-on-addiction-vulnerability-in-adolescents
#20
REVIEW
Ryan W Logan, Brant P Hasler, Erika E Forbes, Peter L Franzen, Mary M Torregrossa, Yanhua H Huang, Daniel J Buysse, Duncan B Clark, Colleen A McClung
Sleep homeostasis and circadian function are important maintaining factors for optimal health and well-being. Conversely, sleep and circadian disruptions are implicated in a variety of adverse health outcomes, including substance use disorders. These risks are particularly salient during adolescence. Adolescents require 8 to 10 hours of sleep per night, although few consistently achieve these durations. A mismatch between developmental changes and social/environmental demands contributes to inadequate sleep...
December 15, 2017: Biological Psychiatry
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