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I Mendez, B W Hansen, C M Grabow, E J L Smedegaard, N B Skogberg, X J Uth, A Bruhn, B Geng, E N Kamavuako
Pattern recognition-based control systems have been widely investigated in prostheses and virtual reality environments to improve amputees' quality of life. Most of these systems use surface electromyography (EMG) to detect user movement intentions. The Myo armband (MYB) is a wireless wearable device, developed by Thalmic Labs, which enables EMG recordings with a limited bandwidth (<100Hz). The aim of this study was to compare MYB's narrow bandwidth with a conventional EMG acquisition system (CONV) that captures the full EMG spectrum to assess its suitability for pattern recognition control...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
Somayeh Jafarinejad, Mahmoud Ghazi-Khansari, Forough Ghasemi, Pezhman Sasanpour, M Reza Hormozi-Nezhad
Catecholamine neurotransmitters, generally including dopamine (DA), epinephrine (EP) and norepinephrine (NE) are known as substantial indicators of various neurological diseases. Simultaneous detection of these compounds and their metabolites is highly recommended in early clinical diagnosis. To this aim, in the present contribution, a high performance colorimetric sensor array has been proposed for the detection and discrimination of catecholamines based on their reducing ability to deposit silver on the surface of gold nanorods (AuNRs)...
August 15, 2017: Scientific Reports
Katharina Eberhardt, Christian Matthäus, Doreen Winter, Cornelia Wiegand, Uta-Christina Hipler, Stephan Diekmann, Jürgen Popp
Senescent cells contribute to tissue aging and dysfunction. Therefore, detecting senescent cells in skin is of interest for skin tumor diagnostics and therapy. Here, we studied the transition into senescence of human dermal fibroblasts (HDFs) in a three-dimensional (3D) human fibroblast-derived matrix (FDM). Senescent and proliferating cells were imaged by Raman spectroscopy (RS) and Fourier transform infrared (FTIR) spectroscopy. The obtained averaged spectra were analyzed using PLS-LDA. For these 3D cultured cells, RS and FTIR could clearly distinguish senescent from proliferating cells...
August 15, 2017: Analyst
Naifu Jin, Maria Paraskevaidi, Kirk T Semple, Francis Luke Martin, Dayi Zhang
Over-usage of antibiotics leads to the widespread induction of antibiotic resistance genes (ARGs). Developing an approach to allow real-time monitoring and fast prediction of ARGs dynamics in clinical or environmental samples has become an urgent matter. Vibrational spectroscopy is potentially an ideal technique towards the characterization of the microbial composition of microbiota as it is non-destructive, high-throughput and label-free. Herein, we employed attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy and developed a spectrochemical tool to quantify the static and dynamic composition of kanamycin resistance in artificial microbiota to evaluate microbial antibiotic resistance...
August 15, 2017: Analytical Chemistry
Guang-Jian Liu, Sheng-Nan Tian, Cui-Yun Li, Guo-Wen Xing, Lei Zhou
Imaging-based total bacterial count and type identification of bacteria play crucial rules in clinical diagnostics, public health, biological and medical science, environmental protection. Herein, we designed and synthesized a series of tetraphenylethenes (TPEs) functionalized with one or two aldehyde, carboxylic acid and quaternary ammonium groups, which were successfully used as fluorescent materials for rapid and efficient staining of 8 kinds of representative bacterial species, including pathogenic bacteria Vibrio cholera, Klebsiella pneumoniae, Listeria monocytogenes and potential bioterrorism agent Yersinia pestis...
August 15, 2017: ACS Applied Materials & Interfaces
Priya Gopal, Riccardo De Gennaro, Marta Silva Dos Santos Guzmao, Rabih Al Rahal Al Orabi, Haihang Wang, Stefano Curtarolo, Marco Fornari, Marco Buongiorno Nardelli
We discuss the application of the Agapito Curtarolo and Buongiorno Nardelli (ACBN0) pseudo-hybrid Hubbard density functional to several transition metal oxides. ACBN0 is a fast, accurate and parameter-free alternative to traditional DFT+U and hybrid exact exchange methods. In ACBN0, the Hubbard energy of DFT+U is calculated via the direct evaluation of the local Coulomb and exchange integrals in which the screening of the bare Coulomb potential is accounted for by a renormalization of the density matrix. We demonstrate the success of the ACBN0 approach for the electronic properties of a series technologically relevant mono-oxides (MnO, CoO, NiO, FeO, both at equilibrium and under pressure)...
August 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Alberto Dellacasa Bellingegni, Emanuele Gruppioni, Giorgio Colazzo, Angelo Davalli, Rinaldo Sacchetti, Eugenio Guglielmelli, Loredana Zollo
BACKGROUND: Currently, the typically adopted hand prosthesis surface electromyography (sEMG) control strategies do not provide the users with a natural control feeling and do not exploit all the potential of commercially available multi-fingered hand prostheses. Pattern recognition and machine learning techniques applied to sEMG can be effective for a natural control based on the residual muscles contraction of amputated people corresponding to phantom limb movements. As the researches has reached an advanced grade accuracy, these algorithms have been proved and the embedding is necessary for the realization of prosthetic devices...
August 14, 2017: Journal of Neuroengineering and Rehabilitation
Wei Wu, Jingdi Chen, Qianshan Ding, Dongmei Yang, Honggang Yu, Jun Lin
BACKGROUND/AIMS: Endoscopic submucosal dissection has been widely accepted. At present, the number of antiplatelet (APT) users has been growing. Moreover, because of high risks of thromboembolism, some patients need to continuously receive APT agents. The relationship between hemorrhage and continuous therapy with low-dose aspirin (LDA) remains controversial. MATERIALS AND METHODS: A systematic search was conducted; studies were screened out- if data of no-anticoagulant/APT drugs use and interrupted and continued-LDA use were reported separately...
August 9, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Na Chen, Ming Rong, Xiaoguang Shao, Heng Zhang, Shupeng Liu, Baijun Dong, Wei Xue, Tingyun Wang, Taihao Li, Jiahua Pan
The surface-enhanced Raman spectroscopy (SERS) of blood serum was investigated to differentiate between prostate cancer (PCa) and benign prostatic hyperplasia (BPH) in males with a prostate-specific antigen level of 4-10 ng/mL, so as to reduce unnecessary biopsies. A total of 240 SERS spectra from blood serum were acquired from 40 PCa subjects and 40 BPH subjects who had all received prostate biopsies and were given a pathological diagnosis. Multivariate statistical techniques, including principal component analysis (PCA) and linear discriminant analysis (LDA) diagnostic algorithms, were used to analyze the spectra data of serum from patients in control (CTR), PCa and BPH groups; results offered a sensitivity of 97...
2017: International Journal of Nanomedicine
Chao Chen, Alina Zare, Huy N Trinh, Gbenga O Omotara, J Tory Cobb, Timotius A Lagaunne
Topic models (e.g., pLSA, LDA, sLDA) have been widely used for segmenting imagery. However, these models are confined to crisp segmentation, forcing a visual word (i.e., an image patch) to belong to one and only one topic. Yet, there are many images in which some regions cannot be assigned a crisp categorical label (e.g., transition regions between a foggy sky and the ground or between sand and water at a beach). In these cases, a visual word is best represented with partial memberships across multiple topics...
August 4, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Ruediger B Mueller, Winfried Graninger, Páris Sidiropoulos, Christoph Goger, Johannes von Kempis
To analyse efficacy and safety of tocilizumab in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and/or tumour necrosis factor (TNF) inhibitors of the Swiss and Austrian patients from the ACT-SURE study. This is a sub-analysis of RA patients from Switzerland and Austria, who participated in the international phase 3b, open-label, ACT-SURE study. Patients with an inadequate response to csDMARDs or TNF antagonists receiving 8 mg/kg of IV tocilizumab every 4 weeks during a 24-week time period were included into the study...
August 3, 2017: Clinical Rheumatology
Adrian Romero-Flores, Laura L McConnell, Cathleen J Hapeman, Mark Ramirez, Alba Torrents
Electronic noses have been widely used in the food industry to monitor process performance and quality control, but use in wastewater and biosolids treatment has not been fully explored. Therefore, we examined the feasibility of an electronic nose to discriminate between treatment conditions of alkaline stabilized biosolids and compared its performance with quantitative analysis of key odorants. Seven lime treatments (0-30% w/w) were prepared and the resultant off-gas was monitored by GC-MS and by an electronic nose equipped with ten metal oxide sensors...
July 27, 2017: Chemosphere
Prashant Singh, Manoj K Harbola, Duane D Johnson
This work constitutes a comprehensive and improved account of electronic-structure and mechan- ical properties of silicon-nitride (Si3N4) polymorphs via van Leeuwen and Baerends (LB) exchange- corrected local density approximation (LDA) that enforces the exact exchange potential asymptotic behavior. The calculated lattice constant, bulk modulus, and electronic band structure of Si3N4 polymorphs are in good agreement with experimental results. We also show that, for a single elec- tron in a hydrogen atom, spherical well, or harmonic oscillator, the LB-corrected LDA reduces the (self-interaction) error to exact total energy to 10%, a factor of 3 to 4 lower than standard LDA, due to a dramatically improved representation of the exchange-potential...
August 2, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Nicolas Giovambattista, Francis W Starr, Peter H Poole
Experiments and computer simulations of the transformations of amorphous ices display different behaviors depending on sample preparation methods and on the rates of change of temperature and pressure to which samples are subjected. In addition to these factors, simulation results also depend strongly on the chosen water model. Using computer simulations of the ST2 water model, we study how the sharpness of the compression-induced transition from low-density amorphous ice (LDA) to high-density amorphous ice (HDA) is influenced by the preparation of LDA...
July 28, 2017: Journal of Chemical Physics
Francesco Longobardi, Valentina Innamorato, Annalisa Di Gioia, Andrea Ventrella, Vincenzo Lippolis, Antonio F Logrieco, Lucia Catucci, Angela Agostiano
Lentil samples coming from two different countries, i.e. Italy and Canada, were analysed using untargeted (1)H NMR fingerprinting in combination with chemometrics in order to build models able to classify them according to their geographical origin. For such aim, Soft Independent Modelling of Class Analogy (SIMCA), k-Nearest Neighbor (k-NN), Principal Component Analysis followed by Linear Discriminant Analysis (PCA-LDA) and Partial Least Squares-Discriminant Analysis (PLS-DA) were applied to the NMR data and the results were compared...
December 15, 2017: Food Chemistry
Mike Donald Tapi Nzali, Sandra Bringay, Christian Lavergne, Caroline Mollevi, Thomas Opitz
BACKGROUND: Social media dedicated to health are increasingly used by patients and health professionals. They are rich textual resources with content generated through free exchange between patients. We are proposing a method to tackle the problem of retrieving clinically relevant information from such social media in order to analyze the quality of life of patients with breast cancer. OBJECTIVE: Our aim was to detect the different topics discussed by patients on social media and to relate them to functional and symptomatic dimensions assessed in the internationally standardized self-administered questionnaires used in cancer clinical trials (European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire Core 30 [QLQ-C30] and breast cancer module [QLQ-BR23])...
July 31, 2017: JMIR Medical Informatics
Miguel G Ramírez-Elías, E S Kolosovas-Machuca, David Kershenobich, Carolina Guzmán, Galileo Escobedo, Francisco J González
Liver fibrosis is a pathological process that can escalate to cirrhosis and then liver failure which are major public health concerns that affect hundreds of millions of people in both developed and developing countries. Detection of liver fibrosis during its earlier stages is a matter of great importance which would allow to prevent the development of cirrhosis in patients with chronic liver disease. In this work, Raman spectroscopy and thermography were evaluated to detect early pathological signs of liver fibrosis in rats in which liver fibrosis was induced using carbon tetrachloride...
July 25, 2017: Photodiagnosis and Photodynamic Therapy
M L Xu, S M Zhu, Y Yu
The economic value of Chinese liquor is closely related with its age. Results from gas chromatograph (GC) analysis indicated that 8 dominant compounds were decreased with the increase of liquor age (0 to 5 years) while ethyl lactate was found to be the most stable dominant compound as no significant change was observed in it during the aging process. Liquor groups with different ages were well-discriminated by principal component analysis (PCA) based on electronic nose signals. High-accurate identification of liquor ages was realized using linear discriminant analysis (LDA) with the accuracy of 98...
July 26, 2017: Scientific Reports
P Melendez, C Romero, P Pithua, M P Marin, P Pinedo, M Duchens
AIMS: To describe milk yield and culling risk in cows diagnosed with left displacement of abomasum (LDA) treated either conservatively, by right flank pyloric omentopexy, or rolling and toggling, compared with normal herdmates from four Chilean dairy herds. METHODS: Historical records were obtained from four commercial dairy farms located in Central Chile for cows with a history of LDA between 2010 and 2012, and healthy herdmates. Cows with LDA were categorised into three groups: cows treated with right omentopexy (ST, n=58), cows treated by toggle suturing (TT, n=15) and cows treated conservatively (CT, n=56)...
July 26, 2017: New Zealand Veterinary Journal
Uwe Heiko Bunz, Benhua Wang, Jinsong Han, Chao Ma, Markus Bender, Kai Seehafer, Andreas Herrmann
A self-assembled nine-element optoelectronic tongue consisting of a po¬sitively charged water soluble poly(para-phenyleneethynylene) and three metal ions (Fe2+, Co2+ and Cu2+) at three different pH-values (pH 7, 10 and 13) discriminates all of the 20 natural amino acids in water. Unknown identification was not ideal. Addition of a highly positively charged green fluorescent protein in the presence of Fe2+, Co2+ and Cu2+ increased the unknown identification to above 86%. Li¬near discriminant analysis (LDA) orders the responses ac¬cording to the amino acid type, i...
July 26, 2017: Chemistry: a European Journal
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