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https://www.readbyqxmd.com/read/28439463/molecular-assessment-of-the-fecal-microbiota-in-healthy-cats-and-dogs-before-and-during-supplementation-with-fructo-oligosaccharides-fos-and-inulin-using-high-throughput-454-pyrosequencing
#1
Jose F Garcia-Mazcorro, Jose R Barcenas-Walls, Jan S Suchodolski, Jörg M Steiner
Prebiotics are selectively fermentable dietary compounds that result in changes in the composition and/or activity of the intestinal microbiota, thus conferring benefits upon host health. In veterinary medicine, commercially available products containing prebiotics have not been well studied with regard to the changes they trigger on the composition of the gut microbiota. This study evaluated the effect of a commercially available nutraceutical containing fructo-oligosaccharides (FOS) and inulin on the fecal microbiota of healthy cats and dogs when administered for 16 days...
2017: PeerJ
https://www.readbyqxmd.com/read/28431087/a-method-for-learning-a-sparse-classifier-in-the-presence-of-missing-data-for-high-dimensional-biological-datasets
#2
Kristen Severson, Brinda Monian, J Christopher Love, Richard D Braatz
Motivation: This work addresses two common issues in building classification models for biological or medical studies: learning a sparse model, where only a subset of a large number of possible predictors is used, and training in the presence of missing data. This work focuses on supervised generative binary classification models, specifically linear discriminant analysis (LDA). The parameters are determined using an expectation maximization algorithm to both address missing data and introduce priors to promote sparsity...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28424959/non-essential-element-concentrations-in-brown-grain-rice-assessment-by-advanced-data-mining-techniques
#3
Roxana Villafañe, Melisa Hidalgo, Analía Piccoli, Eduardo Marchevsky, Roberto Pellerano
The concentrations of 17 non-essential elements (Al, As, Ba, Be, Cd, Ce, Cr, Hg, La, Li, Pb, Sb, Sn, Sr, Th, Ti, and Tl) were determined in brown grain rice samples of two varieties: Fortuna and Largo Fino. The samples were collected from the four main producing regions of Corrientes province (Argentina). Quantitative determinations were performed by inductively coupled plasma mass spectrometry (ICP-MS), using a validated method. The contents of As, Be, Cd, Ce, Cr, Hg, Pb, Sb, Sn, Th, and Tl were very low or not detected in most samples...
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28423846/a-case-study-on-sepsis-using-pubmed-and-deep-learning-for-ontology-learning
#4
Mercedes Arguello Casteleiro, Diego Maseda Fernandez, George Demetriou, Warren Read, Maria Jesus Fernandez Prieto, Julio Des Diz, Goran Nenadic, John Keane, Robert Stevens
We investigate the application of distributional semantics models for facilitating unsupervised extraction of biomedical terms from unannotated corpora. Term extraction is used as the first step of an ontology learning process that aims to (semi-)automatic annotation of biomedical concepts and relations from more than 300K PubMed titles and abstracts. We experimented with both traditional distributional semantics methods such as Latent Semantic Analysis (LSA) and Latent Dirichlet Allocation (LDA) as well as the neural language models CBOW and Skip-gram from Deep Learning...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28420077/recognition-of-the-duration-and-prediction-of-insect-prevalence-of-stored-rough-rice-infested-by-the-red-flour-beetle-tribolium-castaneum-herbst-using-an-electronic-nose
#5
Sai Xu, Zhiyan Zhou, Keliang Li, Sierra Mari Jamir, Xiwen Luo
The purpose of this research is to explore the feasibility of applying an electronic nose for the intelligent monitoring of injurious insects in a stored grain environment. In this study, we employed an electronic nose to sample rough rice that contained three degrees of red flour beetle (Tribolium castaneum Herbst) infestation for different durations-light degree (LD), middle degree (MD), and heavy degree (HD)-and manually investigated the insect situation at the same time. Manual insect situation investigation shows that, in all three rice treatments, the insect amounts gradually decreased after infestation...
April 14, 2017: Sensors
https://www.readbyqxmd.com/read/28418042/selective-orbital-reconstruction-in-tetragonal-fes-a-density-functional-dynamical-mean-field-theory-study
#6
Luis Craco, Stefano Leoni
Transport properties of tetragonal iron monosulfide, mackinawite, show a range of complex features. Semiconductive behavior and proximity to metallic states with nodal superconductivity mark this d-band system as unconventional quantum material. Here, we use the density functional dynamical mean-field theory (DFDMFT) scheme to comprehensively explain why tetragonal FeS shows both semiconducting and metallic responses in contrast to tetragonal FeSe which is a pseudogaped metal above the superconducting transition temperature...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417171/resolution-optimized-headspace-gas-chromatography-ion-mobility-spectrometry-hs-gc-ims-for-non-targeted-olive-oil-profiling
#7
Natalie Gerhardt, Markus Birkenmeier, Daniel Sanders, Sascha Rohn, Philipp Weller
A prototype gas chromatography-ion mobility spectrometry (GC-IMS) system, hyphenating temperature-ramped headspace GC to a modified drift time IMS cell, was evaluated and compared to a conventional, isothermal capillary column (CC)-IMS system on the example of the geographical differentiation of extra virgin olive oils (EVOO) from Spain and Italy. It allows orthogonal, 2D separation of complex samples and individual detection of compounds in robust and compact benchtop systems. The information from the high-resolution 3D fingerprints of volatile organic compound (VOC) fractions of EVOO samples were extracted by specifically developed chemometric MATLAB® routines to differentiate between the different olive oil provenances...
April 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28414459/highly-anisotropic-in-plane-excitons-in-atomically-thin-and-bulklike-1t-rese2
#8
Ashish Arora, Jonathan Noky, Matthias Drüppel, Bhakti Jariwala, Thorsten Deilmann, Robert Schneider, Robert Schmidt, Osvaldo Del Pozo-Zamudio, Torsten Stiehm, Arnab Bhattacharya, Peter Krüger, Steffen Michaelis de Vasconcellos, Michael Rohlfing, Rudolf Bratschitsch
Atomically thin materials such as graphene or MoS2 are of high in-plane symmetry. Crystals with reduced symmetry hold the promise for novel optoelectronic devices based on their anisotropy in current flow or light polarization. Here, we present polarization-resolved optical transmission and photoluminescence spectroscopy of excitons in 1T'-ReSe2. On reducing the crystal thickness from bulk to a monolayer, we observe a strong blue shift of the optical band gap from 1.37 to 1.50 eV. The excitons are strongly polarized with dipole vectors along different crystal directions, which persist from bulk down to monolayer thickness...
April 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28409834/fully-automatic-and-accurate-detection-of-lung-nodules-in-ct-images-using-a-hybrid-feature-set
#9
Furqan Shaukat, Gulistan Raja, Ali Gooya, Alejandro F Frangi
PURPOSE: The aim of this study was to develop a novel technique for lung nodule detection using an optimized feature set. This feature set has been achieved after rigorous experimentation, which has helped in reducing the false positives significantly. METHOD: The proposed method starts with pre-processing, removing any present noise from input images, followed by lung segmentation using optimal thresholding. Then the image is enhanced using multi scale dot enhancement filtering prior to nodule detection and feature extraction...
April 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28408921/phase-segmentation-methods-for-an-automatic-surgical-workflow-analysis
#10
Dinh Tuan Tran, Ryuhei Sakurai, Hirotake Yamazoe, Joo-Ho Lee
In this paper, we present robust methods for automatically segmenting phases in a specified surgical workflow by using latent Dirichlet allocation (LDA) and hidden Markov model (HMM) approaches. More specifically, our goal is to output an appropriate phase label for each given time point of a surgical workflow in an operating room. The fundamental idea behind our work lies in constructing an HMM based on observed values obtained via an LDA topic model covering optical flow motion features of general working contexts, including medical staff, equipment, and materials...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28408798/an-open-randomized-active-controlled-clinical-trial-with-low-dose-ska-cytokines-versus-dmards-evaluating-low-disease-activity-maintenance-in-patients-with-rheumatoid-arthritis
#11
L S Martin-Martin, F Giovannangeli, E Bizzi, U Massafra, E Ballanti, M Cassol, A Migliore
BACKGROUND: Biologic agents are currently the strongest immunosuppressive drugs able to induce remission in rheumatoid arthritis (RA). One of the objectives of the medical scientific community now is how to maintain remission or low disease activity (LDA). The aim of this trial is to evaluate the contribution of low-dose sequential kinetic activation (SKA) IL-4, IL-10, and anti-IL-1 antibodies (10 fg/mL) in patients affected by RA in maintaining LDA or remission obtained after biological therapy...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28407099/discontinuation-of-tofacitinib-after-achieving-low-disease-activity-in-patients-with-rheumatoid-arthritis-a-multicentre-observational-study
#12
Satoshi Kubo, Kunihiro Yamaoka, Koichi Amano, Shuji Nagano, Shigeto Tohma, Eiichi Suematsu, Hayato Nagasawa, Kanako Iwata, Yoshiya Tanaka
Objective.: To determine whether tofacitinib can be discontinued in patients with RA who achieve low disease activity (LDA). Methods.: RA patients with LDA after tofacitinib treatment in a phase III and long-term extension study were enrolled in this multicentre, non-randomized, open, prospective, observational study. The decision of discontinuation or continuation of tofacitinib was determined based on patient-physician decision making with informed consent. The primary endpoint was the proportion of patients who remained tofacitinib-free at post-treatment week 52...
April 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28403854/gait-characterization-in-golden-retriever-muscular-dystrophy-dogs-using-linear-discriminant-analysis
#13
Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel, Jean-Yves Hogrel
BACKGROUND: Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler and more sensitive evaluation of treatment benefits in this important preclinical model. METHODS: Accelerometry was performed twice monthly between the ages of 2 and 12 months on 8 healthy and 20 GRMD dogs. Seven accelerometric parameters were analysed using linear discriminant analysis (LDA)...
April 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28388900/surface-enhanced-raman-spectroscopy-of-blood-serum-based-on-gold-nanoparticles-for-the-diagnosis-of-the-oral-squamous-cell-carcinoma
#14
Yingyun Tan, Bing Yan, Lili Xue, Yi Li, Xianyang Luo, Ping Ji
BACKGROUND: Oral squamous cell carcinoma (OSCC) is becoming more common across the globe. The prognosis of OSCC is largely dependent on the early detection. But the routine oral cavity examination may delay the diagnosis because the early oral malignant lesions may be clinically indistinguishable from benign or inflammatory diseases. In this study, the new diagnostic method is developed by using the surface enhanced Raman spectroscopy (SERS) to detect the serum samples from the cancer patients...
April 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28386705/a-new-concept-and-a-comprehensive-evaluation-of-sysmex-uf-1000i%C3%A2-flow-cytometer-to-identify-culture-negative-urine-specimens-in-patients-with-uti
#15
T Monsen, P Ryden
Urinary tract infections (UTIs) are among the most common bacterial infections in men and urine culture is gold standard for diagnosis. Considering the high prevalence of culture-negative specimens, any method that identifies such specimens is of interest. The aim was to evaluate a new screening concept for flow cytometry analysis (FCA). The outcomes were evaluated against urine culture, uropathogen species and three conventional screening methods. A prospective, consecutive study examined 1,312 urine specimens, collected during January and February 2012...
April 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28383137/provenance-establishment-of-stingless-bee-honey-using-multi-element-analysis-in-combination-with-chemometrics-techniques
#16
Aidil Fahmi Shadan, Naji A Mahat, Wan Aini Wan Ibrahim, Zaiton Ariffin, Dzulkiflee Ismail
As consumption of stingless bee honey has been gaining popularity in many countries including Malaysia, ability to identify accurately its geographical origin proves pertinent for investigating fraudulent activities for consumer protection. Because a chemical signature can be location-specific, multi-element distribution patterns may prove useful for provenancing such product. Using the inductively coupled-plasma optical emission spectrometer as well as principal component analysis (PCA) and linear discriminant analysis (LDA), the distributions of multi-elements in stingless bee honey collected at four different geographical locations (North, West, East, and South) in Johor, Malaysia, were investigated...
April 6, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28379839/a-density-functional-theory-study-of-the-influence-of-exchange-correlation-functionals-on-the-properties-of-feas
#17
Sinéad M Griffin, Nicola A Spaldin
We use density functional theory within the local density approximation (LDA), LDA  +  U, generalised gradient approximation (GGA), GGA  +  U, and hybrid-functional methods to calculate the properties of iron monoarsenide. FeAs, which forms in the MnP structure, is of current interest for potential spintronic applications as well as being the parent compound for the pnictide superconductors. We compare the calculated structural, magnetic and electronic properties obtained using the different functionals to each other and to experiment, and investigate the origin of a recently reported magnetic spiral...
April 5, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28371519/evaluation-of-the-bony-repair-in-rat-cranial-defect-using-near-infrared-reflectance-spectroscopy-and-discriminant-analysis
#18
Leomir A S de Lima, Kássio M G Lima, Lana S S de Oliveira, Aurigena A Araújo, Raimundo Fernandes de Araújo Junior
We set out to determine whether near infrared reflectance spectroscopy (NIRS) combined with principal component analysis-linear discriminant analysis (LDA) or, variable selection techniques employing successive projection algorithm or genetic algorithm (GA) could evaluate the bone repair in cranial critical-size (5 mm) defect after stimulation with collagen sponge scaffold and/or infrared low-level laser therapy directly on the local. Forty-five Winstar rats were divided into nine groups of five each, namely: group H - healthy, n = 5 (without treatment and without cranial critical-size defect), (GI positive control - n = 5, 21 days or n = 5, 30 days) without treatment and with cranial critical-size defect; (GII-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect filled with collagen sponge scaffold; (GIII-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect submitted to low-level laser therapy; (GIV-n = 5, 21 days or n = 5, 30 days) cranial critical-size defect submitted to combined collagen sponge scaffold + low-level laser therapy treatment...
April 3, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28369059/application-of-visible-and-near-infrared-spectroscopy-to-classification-of-miscanthus-species
#19
Xiaoli Jin, Xiaoling Chen, Liang Xiao, Chunhai Shi, Liang Chen, Bin Yu, Zili Yi, Ji Hye Yoo, Kweon Heo, Chang Yeon Yu, Toshihiko Yamada, Erik J Sacks, Junhua Peng
The feasibility of visible and near infrared (NIR) spectroscopy as tool to classify Miscanthus samples was explored in this study. Three types of Miscanthus plants, namely, M. sinensis, M. sacchariflorus and M. fIoridulus, were analyzed using a NIR spectrophotometer. Several classification models based on the NIR spectra data were developed using line discriminated analysis (LDA), partial least squares (PLS), least squares support vector machine regression (LSSVR), radial basis function (RBF) and neural network (NN)...
2017: PloS One
https://www.readbyqxmd.com/read/28368117/lithium-diisopropylamide-nonequilibrium-kinetics-and-lessons-learned-about-rate-limitation
#20
Russell F Algera, Lekha Gupta, Alexander C Hoepker, Jun Liang, Yun Ma, Kanwal J Singh, David B Collum
The kinetics of lithium diisopropylamide (LDA) in tetrahydrofuran under nonequilibrium conditions are reviewed. These conditions correspond to a class of substrates in which the rates of LDA aggregation and solvation events are comparable to the rates at which various fleeting intermediates react with substrate. Substrates displaying these reactivities, by coincidence, happen to be those that react at tractable rates on laboratory time scales at -78 °C. In this strange region of nonlimiting behavior, rate-limiting steps are often poorly defined, sometimes involve deaggregation, and at other times include reaction with substrate...
April 3, 2017: Journal of Organic Chemistry
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