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https://www.readbyqxmd.com/read/28214265/association-between-dopaminergic-dysfunction-and-anxiety-in-de-novo-parkinson-s-disease
#1
Marina Picillo, Gabriella Santangelo, Roberto Erro, Autilia Cozzolino, Marianna Amboni, Carmine Vitale, Paolo Barone, Maria Teresa Pellecchia
OBJECTIVES: To explore the relationships between nigrostriatal dysfunction and neuropsychiatric symptoms (including anxiety, depression and apathy) in a large cohort of newly diagnosed, drug-naïve Parkinson disease (PD) patients compared to a cohort of healthy controls (HC). METHODS: This is a cross-sectional analysis of the Parkinson's Progression Markers Initiative (PPMI) cohort at baseline, including 405 PD patients and 187 HC. Nigrostriatal degeneration was evaluated by means of SPECT DAT scan...
February 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28211813/classification-of-depression-cognitive-disorders-and-co-morbid-depression-and-cognitive-disorders-with-perfusion-spect-neuroimaging
#2
Daniel G Amen, Pavitra Krishnamani, Somayeh Meysami, Andrew Newberg, Cyrus A Raji
BACKGROUND: Depression and cognitive disorders (CDs) are two common co-morbid afflictions that commonly present with overlapping symptoms. OBJECTIVE: To evaluate if perfusion neuroimaging with brain SPECT can distinguish persons with depression from those with CDs or both conditions. METHODS: Inclusion criteria were DSM-IV defined depression or CDs (Alzheimer's disease, vascular dementia, dementia not otherwise specified, and amnestic disorders not otherwise specified) including persons with both (total n = 4,541; 847 CDs, 3,269 depression, 425 with both)...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28211105/joint-reconstruction-of-ictal-inter-ictal-spect-data-for-improved-epileptic-foci-localization
#3
Yothin Rakvongthai, Frederic Fahey, Korn Borvorntanajanya, Supatporn Tepmongkol, Usanee Vutrapongwatana, Katherine Zukotynski, Georges El Fakhri, Jinsong Ouyang
PURPOSE: To improve the performance for localizing epileptic foci, we have developed a joint ictal/inter-ictal SPECT reconstruction method in which ictal and inter-ictal SPECT projections are simultaneously reconstructed to obtain the differential image. METHODS: We have developed a SPECT reconstruction method that jointly reconstructs ictal and inter-ictal SPECT projection data. We performed both phantom and patient studies to evaluate the performance of our joint method for epileptic foci localization as compared with the conventional subtraction method in which the differential image is obtained by subtracting the inter-ictal image from the co-registered ictal image...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28209913/rapid-imaging-of-tumor-cell-death-in-vivo-using-the-c2a-domain-of-synaptotagmin-i
#4
André A Neves, Bangwen Xie, Sarah Fawcett, Israt S Alam, Timothy H Witney, Maaike M de Backer, Julia Summers, William Hughes, Sarah McGuire, Dmitry Soloviev, Jodie Miller, William J Howat, De-En Hu, Tiago B Rodrigues, David Y Lewis, Kevin M Brindle
Cell death is an important target for imaging the early response of tumors to treatment. We describe here validation of a phosphatidylserine-binding agent for detecting tumor cell death in vivo based on the C2A domain of Synaptotagmin-I. Methods: The capability of near infrared fluorophore-labeled and 99mTechnetium- and (111)Indium-labeled derivatives of C2Am for imaging tumor cell death, using planar near infrared fluorescence (NIRF) imaging and single photon computed tomography (SPECT) respectively, was evaluated in implanted and genetically engineered mouse models of lymphoma and in a human colorectal xenograft...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28209907/equivalent-dose-rate-at-1m-of-patients-with-known-or-suspected-neuroendocrine-tumor-exiting-a-nuclear-medicine-department-after-68-ga-dotatoc-18-f-fdopa-or-18-f-fdg-pet-ct-or-111-in-pentetreotide-or-123-i-mibg-spect-ct
#5
Jules Zhang-Yin, Anne-Sophie Dirand, Myriam Sasanelli, Gwenaelle Corrégé, Aude Peudon, Thierry Kiffel, Valérie Nataf, Jérôme Clerc, Françoise Montravers, Jean-Noël Talbot
(123)I-mIBG and (111)In-pentetrotide SPECT have been used for functional imaging of neuroendocrine tumors (NET) for the last two decades. More recently, PET/CT imaging with (18)F-FDG, (18)F-FDOPA and (68)Ga somatostatin-receptor ligands in NETs has been expanding. No direct measurements of the dose rate from NET patients exiting the nuclear medicine department could be found in the literature after PET/CT with (18)F-FDOPA or (68)Ga-DOTATOC, a somatostatin analogue. Methods: We measured the dose rates from NET patients undergoing PET/CT or SPECT/CT in our centers...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28208058/monitoring-of-macrophage-accumulation-in-statin-treated-atherosclerotic-mouse-model-using-sodium-iodide-symporter-imaging-system
#6
Ran Ji Yoo, Min Hwan Kim, Sang-Keun Woo, Kwang Il Kim, Tae Sup Lee, Yang-Kyu Choi, Joo Hyun Kang, Sang Moo Lim, Yong Jin Lee
INTRODUCTION: Macrophages play a key role in atherosclerotic plaque formation in atherosclerosis, but its detailed understanding has poorly investigated until now. Thus, we sought to demonstrate a noninvasive technique for macrophage tracking to atherosclerotic lesions in apolipoprotein E(-/-)(ApoE(-/-)) mice with an imaging system based on sodium iodide symporter (NIS) gene coupled with (99m)Tc-single-photon emission computed tomography (SPECT). METHODS AND RESULTS: Macrophage cells (RAW264...
January 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28207950/simplifying-volumes-of-interest-vois-definition-in-quantitative-spect-beyond-manual-definition-of-3d-whole-organ-vois
#7
Esther M Vicente, Martin A Lodge, Steven P Rowe, Richard L Wahl, Eric C Frey
PURPOSE: We investigated the feasibility of using simpler methods than manual whole-organ volume-of-interest (VOI) definition to estimate the organ activity concentration in single photon emission computed tomography (SPECT) in cases where the activity in the organ can be assumed to be uniformly distributed on the scale of the voxel size. In particular, we investigated an anatomic region-of-interest (ROI) defined in a single transaxial slice, and a single sphere placed inside the organ boundaries...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28205000/aortic-knob-width-reflects-left-ventricular-diastolic-function-assessed-by-gated-myocardial-perfusion-single-photon-emission-computed-tomography-in-patients-with-normal-myocardial-perfusion
#8
Satoshi Kurisu, Tadanao Higaki, Yoji Sumimoto, Hiroki Ikenaga, Noriaki Watanabe, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Aortic knob width on chest radiography represents the extent of aortic dialation and tortuosity of the aortic arch. We tested the hypothesis that aortic knob width reflected left ventricular (LV) diastolic function assessed by gated myocardial perfusion single photon emission computed tomography (SPECT) in patients with normal myocardial perfusion. METHODS: One hundred and thirty patients with preserved LV ejection fraction and normal myocardial perfusion were enrolled in this study...
February 15, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28198536/prevalence-of-risk-factors-and-asymptomatic-carotid-atherosclerosis-in-diabetic-patients-screened-for-silent-myocardial-ischemia-by-spect-myocardial-imaging
#9
Irena Peovska Mitevska, Natalija Baneva, Marijan Bosevski, Elizabeta Srbinovska Kostovska
BACKGROUND: The aim of the study was to evaluate whether there is any association between myocardial ischemia, common risk factors and carotid artery ultrasound parameters in asymptomatic type 2 diabetic (DMT2) patients. MATERIAL AND METHODS: 60 asymptomatic DMT2 patients (pts) without known coronary artery disease (CAD) underwent one day rest Dypiridamole stress Tc-99m sestamibi single photon emission computed tomography myocardial perfusion scintigraphy (MPS)...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28198517/a-monte-carlo-study-for-optimizing-the-detector-of-spect-imaging-using-a-xcat-human-phantom
#10
Mohammad Khoshakhlagh, Jalil Pirayesh Islamian, Seyyed Mohammad Abedi, Babak Mahmoudian, Masoud Shayesteh Azar
BACKGROUND: Acquiring a high quality image has assigned an important concern for obtaining accurate diagnosis in nuclear medicine. Detector is a critical component of Single Photon Emission Computed Tomography (SPECT) imaging system for giving accurate information from exact pattern of radionuclide distribution in the target organ. The images are strongly affected by the attenuation, scattering, and response of the detector. The conventional detector is mainly made from sodium iodide activated by thallium [NaI(Tl)] in nuclear medicine imaging...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28197324/-125-i-f56-peptide-as-radioanalysis-agent-targeting-vegfr1-in-mice-xenografted-with-human-gastric-tumor
#11
Hua Zhu, Chuanke Zhao, Fei Liu, Lixin Wang, Junnan Feng, Chengchao Shou, Zhi Yang
(125)I-Radiolabeled F56 peptide was designed as a radioactive analogue of F56 (peptide WHSDMEWWYLLG) to bind with VEGFR1 receptor. It was synthesized in high radiochemical yield and specific activity. The in vitro stability of (125)I-F56 was tested, and the bioactivity of (125)I-F56 was confirmed by both cell uptake and binding affinity measurement in VEGFR1 positive BGC-823 cells. The time-radioactivity relationship and biodistribution of (125)I-F56 tracer were conducted using nude mice bearing human gastric carcinoma BGC-823, by noninvasive micro-SPECT/CT imaging...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28197219/factors-determining-altered-perfusion-after-acute-pulmonary-embolism-assessed-by-quantified-single-photon-emission-computed-tomography-perfusion-scan
#12
Marc Meysman, Hendrik Everaert, Walter Vincken
AIM OF THE STUDY: The aim of the study was to analyze the evolution of perfusion (Q)-defects in patients treated for acute pulmonary embolism (PE), correlation with baseline parameters and evaluation of recurrence risk. METHODS: This is a single-center prospective observational cohort study in symptomatic normotensive PE. Comparison of the ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT) acquired at baseline with a quantified SPECT (Q-SPECT) repeated at 1 week and 6 months...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28196364/technetium-99m-or-cy7-labeled-rituximab-as-an-imaging-agent-for-non-hodgkin-lymphoma
#13
Ximena Camacho, Camila Longo Machado, María Fernanda García, Juan Pablo Gambini, Agustina Banchero, Marcelo Fernández, Natalia Oddone, Daniela Bertolini Zanatta, Carolina Rosal, Carlos Alberto Buchpiguel, Roger Chammas, Eloisa Riva, Pablo Cabral
INTRODUCTION: Rituximab was the first monoclonal antibody approved for the treatment of B-cell non-Hodgkin lymphoma (NHL) expressing CD20 antigen. This antibody has also the potential to be used as a specific fluorescent and radiolabel agent for targeting NHL. OBJECTIVE: To radiolabel rituximab with technetium-99m (99mTc) or Cy7 and evaluate both probes as potential imaging agents for NHL. METHODS: Rituximab was derivatized with the trifluoroacetyl hydrazino protected form of succinimidyl ester of HYNIC and radiolabeled with 99mTc...
February 15, 2017: Oncology
https://www.readbyqxmd.com/read/28195902/mibg-localization-of-a-subclinical-paraganglioma-of-the-bladder
#14
Ayman Mithqal, Pasha Darvishi, Patrice Rehm
Urinary bladder paragangliomas are very rare, and the majority are hormonally active. Nonfunctioning paragangliomas are even rarer and more difficult to diagnose because of absence of catecholamine secretion. We present a 27-year-old woman with an asymptomatic paraganglioma of the urinary bladder discovered incidentally in a patient with prior resection of a functional pararenal paraganglioma. Metabolic profiles and cystoscopy were nondiagnostic. We demonstrate the increased sensitivity of I-MIBG SPECT/CT compared with planar scintigraphy for detection of a nonfunctional paraganglioma of the urinary bladder, which makes it valuable in evaluation of functional and nonfunctional paragangliomas...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28194728/diagnostic-performance-of-the-quantification-of-myocardium-at-risk-from-mpi-spect-cta-2g-fusion-for-detecting-obstructive-coronary-disease-a-multicenter-trial
#15
Marina Piccinelli, Cesar Santana, Gopi Kiran R Sirineni, Russell D Folks, C David Cooke, Chesnal D Arepalli, Santiago Aguade-Bruix, Zohar Keidar, Alex Frenkel, Ora Israel, Jaume Candell-Riera, Ernest V Garcia
BACKGROUND: The effective non-invasive identification of coronary artery disease (CAD) and its proper referral for invasive treatment are still unresolved issues. We evaluated our quantification of myocardium at risk (MAR) from our second generation 3D MPI/CTA fusion framework for the detection and localization of obstructive coronary disease. METHODS: Studies from 48 patients who had rest/stress MPI, CTA, and ICA were analyzed from 3 different institutions. From the CTA, a 3D biventricular surface of the myocardium with superimposed coronaries was extracted and fused to the perfusion distribution...
February 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28194726/validation-of-cadmium-zinc-telluride-camera-for-measurement-of-left-ventricular-systolic-performance
#16
Elisabeth Coupez, Merlin Charles, Viateur Tuyisenge, Laurent Sarry, Bruno Pereira, Jean René Lusson, Louis Boyer, Lucie Cassagnes
BACKGROUND: There are paucity of data comparing measurements of left ventricular systolic performance using cadmium-zinc-telluride (CZT) semiconductor cameras with other imaging modalities. This study compared the new system with echocardiography (echo) and cardiac magnetic resonance (CMR) imaging. METHODS: 60 Patients presenting with ST-elevated myocardial infarction (MI) were included. Each patient underwent echo, myocardial perfusion imaging using Spectrum Dynamics D-SPECT(r) (CZT-SPECT), and CMR 6 weeks after MI...
February 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28194631/development-of-a-new-folate-derived-ga-68-based-pet-imaging-agent
#17
Christian Brand, Valerie A Longo, Mike Groaning, Wolfgang A Weber, Thomas Reiner
PURPOSE: The folate receptor (FR) has emerged as an interesting diagnostic and therapeutic drug target with many potential applications in oncologic and inflammatory disorders. It was therefore the aim of this study to develop a folate-derived Ga-68-based positron emission tomography (PET) imaging tracer that is straightforward to radiolabel and could be broadly used in clinical studies. We validated its target binding affinity and specificity and compared it to [(99m)Tc]EC20, the folate single-photon emission computed tomography (SPECT) imaging tracer that has been most extensively studied clinically so far...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28194630/source-based-morphometry-multivariate-approach-to-analyze-123-i-fp-cit-spect-imaging
#18
Enrico Premi, V D Calhoun, V Garibotto, R Turrone, A Alberici, E Cottini, A Pilotto, S Gazzina, M Magoni, B Paghera, B Borroni, A Padovani
PURPOSE: [(123)I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [(123)I]FP-CIT may be considered for other monoaminergic systems, in particular the serotonin transporter (SERT). Independent component analysis (ICA) implemented in source-based morphometry (SBM) could represent an alternative method to explore monoaminergic pathways, studying the relationship among voxels and grouping them into "neurotransmission" networks...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28194558/structural-imaging-of-mild-traumatic-brain-injury-may-not-be-enough-overview-of-functional-and-metabolic-imaging-of-mild-traumatic-brain-injury
#19
REVIEW
Samuel S Shin, James W Bales, C Edward Dixon, Misun Hwang
A majority of patients with traumatic brain injury (TBI) present as mild injury with no findings on conventional clinical imaging methods. Due to this difficulty of imaging assessment on mild TBI patients, there has been much emphasis on the development of diffusion imaging modalities such as diffusion tensor imaging (DTI). However, basic science research in TBI shows that many of the functional and metabolic abnormalities in TBI may be present even in the absence of structural damage. Moreover, structural damage may be present at a microscopic and molecular level that is not detectable by structural imaging modality...
February 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28193503/clinical-translation-of-a-psma-inhibitor-for-99m-tc-based-spect
#20
Guillermina Ferro-Flores, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Emmanuel Orocio-Rodríguez, Jenny Davanzo, Francisco O García-Pérez
BACKGROUND: Prostate-specific membrane antigen (PSMA) is highly over-expressed in advanced prostate cancers. (68)Ga-labeled PSMA inhibitors (iPSMA) are currently used for prostate cancer detection by PET imaging. The availability of simple, efficient and reproducible radiolabeling procedures is essential for developing new SPECT radiopharmaceuticals for clinical translation. The aim of this research was to prepare (99m)Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ((99m)Tc-EDDA/HYNIC-iPSMA) obtained from lyophilized kit formulations and evaluate the in vitro and in vivo radiopharmaceutical binding to prostate cancer cells over-expressing PSMA, as well as the (99m)Tc-EDDA/HYNIC-iPSMA normal biodistribution in humans and the preliminary uptake in patients with prostate cancer...
February 3, 2017: Nuclear Medicine and Biology
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