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https://www.readbyqxmd.com/read/29143222/quantitative-analysis-of-the-level-of-readability-of-online-emergency-radiology-based-patient-education-resources
#1
David R Hansberry, Michael D'Angelo, Michael D White, Arpan V Prabhu, Mougnyan Cox, Nitin Agarwal, Sandeep Deshmukh
PURPOSE: The vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology. METHODS: Using Google, 23 terms were searched, and the top 10 results were recorded. Each link was evaluated for its readability level using a set of ten reputable readability scales...
November 15, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29140113/prediction-of-pancreatic-neuroendocrine-tumor-grade-based-on-ct-features-and-texture-analysis
#2
Rodrigo Canellas, Kristine S Burk, Anushri Parakh, Dushyant V Sahani
OBJECTIVE: The purposes of this study were to assess whether CT texture analysis and CT features are predictive of pancreatic neuroendocrine tumor (PNET) grade based on the World Health Organization (WHO) classification and to identify features related to disease progression after surgery. MATERIALS AND METHODS: Preoperative contrast-enhanced CT images of 101 patients with PNETs were assessed. The images were evaluated for tumor location, tumor size, tumor pattern, predominantly solid or cystic composition, presence of calcification, presence of heterogeneous enhancement on contrast-enhanced images, presence of pancreatic duct dilatation, presence of pancreatic atrophy, presence of vascular involvement by the tumor, and presence of lymphadenopathy...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29134353/scan-time-reduction-in-diffusion-weighted-imaging-of-the-pancreas-using-a-simultaneous-multislice-technique-with-different-acceleration-factors-how-fast-can-we-go
#3
Jana Taron, Petros Martirosian, Thomas Kuestner, Nina F Schwenzer, Ahmed Othman, Jakob Weiß, Mike Notohamiprodjo, Konstantin Nikolaou, Christina Schraml
OBJECTIVES: To investigate the feasibility of simultaneous multislice-accelerated diffusion-weighted imaging (sms-DWI) of the pancreas with different acceleration factors and its influence on image quality, acquisition time and apparent diffusion coefficients (ADCs) in comparison to conventional sequences. METHODS: DWI of the pancreas was performed at 1.5T in ten healthy volunteers and 20 patients with sms-accelerated echo-planar DWI using two different sms-acceleration factors of 2 and 3 (sms2/3-DWI)...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29118705/oxaliplatin-induced-hyperammonemic-encephalopathy-in-a-patient-with-metastatic-pancreatic-cancer-a-case-report
#4
Takatsugu Ogata, Hironaga Satake, Misato Ogata, Yukimasa Hatachi, Hisateru Yasui
Oxaliplatin-based chemotherapy is widely used to treat advanced cancer. Oxaliplatin-induced hyperammonemic encephalopathy is rarely reported. Here, we report a case of oxaliplatin-induced hyperammonemic encephalopathy occurring after gemcitabine plus oxaliplatin (GEMOX) chemotherapy in a patient with pancreatic cancer. A 76-year-old man received GEMOX regimen as first-line treatment for pancreatic adenocarcinoma with peritoneal dissemination. GEMOX consists of gemcitabine (1,000 mg/m(2)) and oxaliplatin (100 mg/m(2)) on day 1, repeated every 2 weeks...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29099712/influence-of-testosterone-on-morphological-changes-in-pancreatic-islets-and-liver-tissue-of-rats-with-alloxan-induced-diabetes
#5
S Kandelaki, M Kharabadze, I Sikharulidze, M Velijanashvili, M Kakabadze, D Kordzaia
The role of exogenous testosterone (methyltrienolone) in the repair of damaged pancreatic islet and liver cells during alloxan diabetes was studied. Modeling of diabetes was performed through single intraperitoneal injection of Alloxan, with the dose 2 mg per 10 g of body weight. Pancreatic and liver tissues were investigated microscopically using 3-4 µm slices embedded in paraffin and stained with hematoxylin and eosin. Software Adobe Photoshop was used to measure the areas of pancreatic islets as well as areas of necrotic foci in these islets of animals with Alloxan-induced experimental diabetes...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29093761/a-prospective-study-of-dietary-and-supplemental-zinc-intake-and-risk-of-type-2-diabetes-depending-on-genetic-variation-in-slc30a8
#6
Isabel Drake, George Hindy, Ulrika Ericson, Marju Orho-Melander
Background: The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an increased risk of type 2 diabetes (T2D). We hypothesized that the association between zinc intake and T2D may be modified by the SLC30A8 genotype. Results: We carried out a prospective study among subjects with no history cardio-metabolic diseases in the Malmö Diet and Cancer Study cohort (N = 26,132, 38% men; 86% with genotype data)...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/29093353/work-sustainability-among-male-cancer-survivors-after-returning-to-work
#7
Motoki Endo, Yasuo Haruyama, Go Muto, Kosuke Kiyohara, Tetsuya Mizoue, Noriko Kojimahara, Naohito Yamaguchi
BACKGROUND: Few studies have investigated the work continuance rate among cancer survivors after return to work (RTW). The objective of this study was to clarify work sustainability after RTW among Japanese male cancer survivors. METHODS: We collected data on male cancer survivors from an occupational health register. Inclusion criteria were as follows: employees who returned to work after an episode of sick leave due to clinically certified cancer diagnosed between January 1, 2000 and December 31, 2011...
October 28, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29080821/poly-carboxybetaine-methacrylate-functionalized-magnetic-composite-particles-a-biofriendly-support-for-lipase-immobilization
#8
Haishan Qi, Yan Du, Guannan Hu, Lei Zhang
In this work, poly(carboxybetaine methacrylate) as an extremely hydrophilic polymer was modified on superparamagnetic Fe3O4 nanoparticles (pCB-Fe3O4), which were employed to immobilize porcine pancreatic lipase. The properties of immobilized lipase were investigated in comparison with the free enzyme counterpart. Enzymatic stability, reusability, and activity of the immobilized lipase were found significantly superior to that of the free lipase. In particular, at an elevated temperature of 60°C, the immobilized lipase retained 50% of its initial activity after 150min, while the free enzyme displayed only one-third activity of the immobilized enzyme...
October 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29068809/advances-in-managing-and-preventing-thromboembolic-disease-in-cancer-patients
#9
Anthony Maraveyas, Iqtedar Muazzam, Simon Noble, George Bozas
PURPOSE OF REVIEW: To update on new data for low-molecular weight heparins (LMWHs) and the direct oral anticoagulants (DOACs) for the treatment and prevention of cancer-associated thrombosis (CAT), to discuss progress with the risk-adaptive management scores (RAMS) and update on increased dose primary thromboprophylaxis (IDPTP). RECENT FINDINGS: In a pooled meta-analysis of 1132 cancer patients who received DOACs vs. vitamin K analogues (VKAs), recurrence of venous thromboembolism (VTE) was reduced from 6...
December 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29067062/efficacy-of-early-oral-refeeding-in-patients-of-mild-acute-pancreatitis
#10
Shahum Khan, Waqas Ahmed Ranjha, Hassan Tariq, Hareem Nawaz
OBJECTIVE: To compare Early Oral Refeeding (EORF) with Routine Oral Refeeding (RORF) on outcome of patients of mild Acute Pancreatitis (AP) in terms of Mean Length of Hospital Stay (LOHS). METHODS: This randomized controlled trialwas conducted atSurgical Department CMH Rawalpindi, from 1st Feb 2015 to 01st Aug 2016. A total of 60 patients with pain epigastrium were enrolled in the study. Severity of pancreatitis was assessed using Glasgow Scale. Patients were randomly divided in two groups...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29045525/clinical-benefit-of-systemic-treatment-in-patients-with-advanced-pancreatic-and-gastro-intestinal-neuroendocrine-tumours-according-to-esmo-mcbs-and-asco-framework
#11
L D de Hosson, L M van Veenendaal, Y Schuller, W T Zandee, W W de Herder, M E T Tesselaar, H J Klümpen, A M E Walenkamp
BackgroundAssessment of clinical benefit of systemic treatments of rare diseases including gastroenteropancreatic neuroendocrine tumors (GEP-NET) is challenging. Recently several tools have been developed to grade clinical benefit of cancer drugs. European Society for Medical Oncology (ESMO) has developed the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The American Society of Clinical Oncology (ASCO) developed and revised the ASCO framework consisting of the Net Health Benefit (NHB) score juxtaposed against the costs of the treatment...
September 26, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29019651/combining-machine-learning-and-nanofluidic-technology-to-diagnose-pancreatic-cancer-using-exosomes
#12
Jina Ko, Neha Bhagwat, Stephanie S Yee, Natalia Ortiz, Amine Sahmoud, Taylor Black, Nicole M Aiello, Lydie McKenzie, Mark O'Hara, Colleen Redlinger, Janae Romeo, Erica L Carpenter, Ben Z Stanger, David Issadore
Circulating exosomes contain a wealth of proteomic and genetic information, presenting an enormous opportunity in cancer diagnostics. While microfluidic approaches have been used to successfully isolate cells from complex samples, scaling these approaches for exosome isolation has been limited by the low throughput and susceptibility to clogging of nanofluidics. Moreover, the analysis of exosomal biomarkers is confounded by substantial heterogeneity between patients and within a tumor itself. To address these challenges, we developed a multi-channel nanofluidic system to analyze crude clinical samples...
October 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28986817/isobaric-labeling-based-lc-ms-ms-strategy-for-comprehensive-profiling-of-human-pancreatic-tissue-proteome
#13
Chih-Wei Liu, Qibin Zhang
The pancreas is an organ with both endocrine and exocrine functions, and various pathologies, such as pancreatic cancer and diabetes are associated with this organ. Owing to the limited pancreatic biopsy samples available for research, it is critical to make the best use of cadaveric pancreatic tissue for biomarker studies and mechanistic understanding of pancreas-related pathologies. Discovery-phase quantitative proteomics has attracted a lot of attention for its capabilities in large-scale protein identification and accurate protein quantification...
October 7, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28984401/cyclic-depsipeptide-be-43547a2-synthesis-and-activity-against-pancreatic-cancer-stem-cells
#14
Yuanjun Sun, Yahui Ding, Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang, Yue Chen
Asymmetric total synthesis of the cyclic depsipeptide BE-43547A2 was achieved in 15 linear steps on a 350 mg scale in one batch. The synthesis features the highly diastereoselective construction of an α-hydroxy-β-ketoamide through α-hydroxylation with a d.r. of up to 86:1. BE-43547A2 significantly reduces the percentage of pancreatic cancer stem cells (PCSCs) in Panc-1 cell cultures, and dramatically reduces the tumorsphere-forming capability of Panc-1 cells. An in vivo tumor-initiation assay, a gold standard for cancer stem cell assays, confirmed that BE-43547A2 can abolish the tumorigenesis of Panc-1 cells...
October 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28979141/genome-scale-analysis-to-identify-prognostic-markers-in-patients-with-early-stage-pancreatic-ductal-adenocarcinoma-after-pancreaticoduodenectomy
#15
Xiwen Liao, Ketuan Huang, Rui Huang, Xiaoguang Liu, Chuangye Han, Long Yu, Tingdong Yu, Chengkun Yang, Xiangkun Wang, Tao Peng
BACKGROUND: Molecular analysis is a promising source of clinically useful prognostic biomarkers. The aim of this investigation was to identify prognostic biomarkers for patients with early-stage pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy. METHODS: An RNA sequencing dataset of PDAC was obtained from The Cancer Genome Atlas. Survival analysis and weighted gene co-expression network analysis were used to investigate the prognostic markers of early-stage PDAC after pancreaticoduodenectomy...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28976478/compressed-sensing-accelerated-3-dimensional-magnetic-resonance-cholangiopancreatography-application-in-suspected-pancreatic-diseases
#16
Liang Zhu, Xi Wu, Zhaoyong Sun, Zhengyu Jin, Elisabeth Weiland, Esther Raithel, Tianyi Qian, Huadan Xue
OBJECTIVES: The aims of this study were to prospectively evaluate image quality, duct visibility, and diagnostic performance in duct-related pathologies of compressed-sensing (CS) accelerated 3-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) prototype protocols and compare these with those of conventional 3D MRCP protocol in patients with suspected pancreatic diseases. MATERIAL AND METHODS: The institutional review board approved this prospective study and all patients provided written informed consent...
September 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28963048/patient-adapted-respiratory-training-effect-on-navigator-triggered-3d-mrcp-in-painful-pancreatobiliary-disorders
#17
Liang Zhu, Zhao-Yong Sun, Hua-Dan Xue, Dong Liu, Tian-Yi Qian, Patrick Asbach, Zheng-Yu Jin
PURPOSE: To compare the image quality of navigator-triggered (NT) 3D MR cholangiopancreatography (MRCP) with and without a patient-adapted respiratory training, in clinical patients with painful pancreatobiliary disorders. MATERIALS AND METHODS: With institutional review board approval, hospitalized patients with painful pancreatobiliary disorders who were scheduled for MRCP study were prospectively enrolled. The numerical rating scale (NRS) of abdominal pain during the examination was recorded...
September 27, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28957862/triglyceride-lowering-trials
#18
Anthony C Keech, Alicia J Jenkins
PURPOSE OF REVIEW: We provide an overview of current evidence about the independent role of high triglyceride levels for cardiovascular risk and for acute pancreatitis. RECENT FINDINGS: Natural experiments of Mendelian randomization have given us a deeper understanding about the molecular pathways involved in triglyceride metabolism. Individuals with low-triglyceride levels generally have lower rates of cardiovascular disease (CVD). There has been a significant growth in the development of new agents that modulate enzymes involved in a variety of aspects of triglyceride packaging into VLDL or chylomicron particles, and triglyceride catabolism...
September 27, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28954919/pancreatic-%C3%AE-cell-function-and-prognosis-of-nondiabetic-patients-with-ischemic-stroke
#19
Yuesong Pan, Weiqi Chen, Jing Jing, Huaguang Zheng, Qian Jia, Hao Li, Xingquan Zhao, Liping Liu, Yongjun Wang, Yan He, Yilong Wang
BACKGROUND AND PURPOSE: Pancreatic β-cell dysfunction is an important factor in the development of type 2 diabetes mellitus. This study aimed to estimate the association between β-cell dysfunction and prognosis of nondiabetic patients with ischemic stroke. METHODS: Patients with ischemic stroke without a history of diabetes mellitus in the ACROSS-China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry were included. Disposition index was estimated as computer-based model of homeostatic model assessment 2-β%/homeostatic model assessment 2-insulin resistance based on fasting C-peptide level...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28940826/trichostatin-a-preferentially-reverses-the-upregulation-of-gene-expression-levels-induced-by-gain-of-chromosome-7-in-colorectal-cancer-cell-lines
#20
Floryne O Buishand, Eric Cardin, Yue Hu, Thomas Ried
Epithelial cancers are defined by a tumor-specific distribution of chromosomal aneuploidies that are maintained when cells metastasize and are conserved in cell lines derived from primary tumors. Correlations between genomic copy number and gene expression have been observed for different tumors including, colorectal (CRC), breast, and pancreatic cancer. These ploidy-driven transcriptional deregulations are characterized by low-level expression changes of most genes on the affected chromosomes. The emergence of these aberrations at an early stage of tumorigenesis and the strong selection for the maintenance of these aneuploidies suggest that aneuploidy-dependent transcriptional deregulations might contribute to cellular transformation and maintenance of the malignant phenotype...
September 23, 2017: Genes, Chromosomes & Cancer
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