keyword
MENU ▼
Read by QxMD icon Read
search

pancreatitis scales

keyword
https://www.readbyqxmd.com/read/29346214/validation-of-biomarkers-for-early-detection-of-pancreatic-cancer-summary-of-the-alliance-of-pancreatic-cancer-consortia-for-biomarkers-for-early-detection-workshop
#1
Matthew R Young, Paul D Wagner, Sharmistha Ghosh, Jo Ann Rinaudo, Stuart G Baker, Kenneth S Zaret, Michael Goggins, Sudhir Srivastava
Pancreatic cancer is the third leading cause of cancer death in the United States, and the 5-year relative survival for patients diagnosed with pancreatic cancer is less than 10%. Early intervention is the key to a better survival outcome. Currently, there are no biomarkers that can reliably detect pancreatic cancer at an early stage or identify precursors that are destined to progress to malignancy. The National Cancer Institute in partnership with the Kenner Family Research Fund and the Pancreatic Cancer Action Network convened a Data Jamboree on Biomarkers workshop on December 5, 2016, to discuss and evaluate existing or newly developed biomarkers and imaging methods for early detection of pancreatic cancer...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29344199/expression-and-prognostic-significance-of-doublecortin-like-kinase-1-in-patients-with-hepatocellular-carcinoma
#2
Mengjiao Fan, Niansong Qian, Guanghai Dai
Doublecortin-like kinase 1 (DCLK1), a putative cancer stem cell marker in intestinal and pancreatic tumors, is associated with tumor pathogenesis and progression, and poor survival outcomes in numerous types of cancer. However, DCLK1 expression and its prognostic value remain unclear in hepatocellular carcinoma (HCC). In the present study, the expression of DCLK1 was assessed using immunohistochemistry in 96 resected HCC and 68 adjacent tissue specimens. The staining intensity and the percentage of stained cells were scored on a scale of 0-3 and 0-4, respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29341865/evidence-of-genetic-predisposition-for-metabolically-healthy-obesity-and-metabolically-obese-normal-weight
#3
Lam Opal Huang, Ruth Loos, Tuomas Oskari Kilpeläinen
Obesity has evolved into a global pandemic, which constitutes a major threat to public health. The majority of obesity-related health care costs are due to cardiometabolic complications, such as insulin resistance, dyslipidemia, and hypertension, which are risk factors for type 2 diabetes and cardiovascular disease. However, many obese individuals, often called metabolically healthy obese (MHO), seem to be protected from these cardiometabolic complications. Conversely, there is a group of individuals who suffer from cardiometabolic complications despite being of normal weight; a condition termed metabolically obese normal weight (MONW)...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29341146/defining-the-molecular-pathology-of-pancreatic-body-and-tail-adenocarcinoma
#4
S B Dreyer, N B Jamieson, R Upstill-Goddard, P J Bailey, C J McKay, A V Biankin, D K Chang
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little improvement in survival over the past 50 years. Recent large-scale genomic studies have improved understanding of the genomic and transcriptomic landscape of the disease, yet very little is known about molecular heterogeneity according to tumour location in the pancreas; body and tail PDACs especially tend to have a significantly worse prognosis. The aim was to investigate the molecular differences between PDAC of the head and those of the body and tail of the pancreas...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29330793/hypoxia-induced-metabolomic-alterations-in-pancreatic-cancer-cells
#5
Venugopal Gunda, Sushil Kumar, Aneesha Dasgupta, Pankaj K Singh
Hypoxic conditions in the pancreatic tumor microenvironment lead to the stabilization of hypoxia-inducible factor-1 alpha (HIF-1α), which acts as the master regulator of cancer cell metabolism. HIF-1α-mediated metabolic reprogramming results in large-scale metabolite perturbations. Characterization of the metabolic intermediates and the corresponding metabolic pathways altered by HIF-1α would facilitate the identification of therapeutic targets for hypoxic microenvironments prevalent in pancreatic ductal adenocarcinoma and other solid tumors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29305154/towards-a-comprehensive-understanding-of-emerging-dynamics-and-function-of-pancreatic-islets-a-complex-network-approach-comment-on-network-science-of-biological-systems-at-different-scales-a-review-by-gosak-et-al
#6
https://www.readbyqxmd.com/read/29283208/microphysiological-analysis-platform-of-pancreatic-islet-%C3%AE-cell-spheroids
#7
Sang Hun Lee, SoonGweon Hong, Jihwan Song, Byungrae Cho, Esther J Han, Sravani Kondapavulur, Dongchoul Kim, Luke P Lee
The hallmarks of diabetics are insufficient secretion of insulin and dysregulation of glucagon. It is critical to understand release mechanisms of insulin, glucagon, and other hormones from the islets of Langerhans. In spite of remarkable advancements in diabetes research and practice, robust and reproducible models that can measure pancreatic β-cell function are lacking. Here, a microphysiological analysis platform (MAP) that allows the uniform 3D spheroid formation of pancreatic β-cell islets, large-scale morphological phenotyping, and gene expression mapping of chronic glycemia and lipidemia development is reported...
December 28, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29273939/impact-of-tissue-transport-on-pet-hypoxia-quantification-in-pancreatic-tumours
#8
Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C Dhani, Iram Siddiqui, David W Hedley, David A Jaffray
BACKGROUND: The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate of hypoxia-sensitive PET tracers is slow, comparable to the rate of diffusive equilibration in some tissue types, including mucinous and necrotic tissue. This means that tracer uptake on the scale of a PET imaging voxel-large enough to include such tissue and hypoxic cells-can be as much determined by tissue transport properties as it is by hypoxia...
December 22, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29273609/bone-marrow-edema-associated-with-everolimus
#9
Rachel Lebovic McDevitt, Chelsey Quinlan, Katie Hersberger, Vaibhav Sahai
PURPOSE: The case of a patient who experienced bone marrow edema and pain in both feet and a compression fracture of one heel bone after several months of everolimus use is reported. SUMMARY: A 62-year-old woman with a grade 1 metastatic pancreatic neuroendocrine tumor (pNET) developed bilateral lower extremity edema and pain approximately 4 months after initiation of treatment with everolimus, an inhibitor of mammalian (or mechanistic) target of rapamycin (mTOR)...
January 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29261524/core-set-of-patient-reported-outcomes-in-pancreatic-cancer-coprac-an-international-delphi-study-among-patients-and-health-care-providers
#10
Lennart B van Rijssen, Arja Gerritsen, Inge Henselmans, Mirjam A Sprangers, Marc Jacobs, Claudio Bassi, Olivier R Busch, Carlos Fernández-Del Castillo, Zhi Ven Fong, Jin He, Jin-Young Jang, Ammar A Javed, Sun-Whe Kim, Laura Maggino, Abhishek Mitra, Vikas Ostwal, Silvia Pellegrini, Shailesh V Shrikhande, Johanna W Wilmink, Christopher L Wolfgang, Hanneke W van Laarhoven, Marc G Besselink
OBJECTIVE: To establish an international core set of patient-reported outcomes (PROs) selected by both patients and healthcare providers (HCPs) from the United States (US), Europe, and Asia. SUMMARY BACKGROUND DATA: PROs are increasingly recognized in pancreatic cancer studies. There is no consensus on which of the many available PROs are most important. METHODS: A multicenter Delphi study among patients with pancreatic cancer (curative- and palliative-setting) and HCPs in 6 pancreatic centers in the US (Baltimore, Boston), Europe (Amsterdam, Verona), and Asia (Mumbai, Seoul) was performed...
December 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29229751/suv420h2-is-an-epigenetic-regulator-of-epithelial-mesenchymal-states-in-pancreatic-cancer
#11
Manuel Viotti, Catherine Wilson, Mark McCleland, Hartmut Koeppen, Benjamin Haley, Suchit Jhunjhunwala, Christiaan Klijn, Zora Modrusan, David Arnott, Marie Classon, Jean-Philippe Stephan, Ira Mellman
Epithelial-to-mesenchymal transition is implicated in metastasis, where carcinoma cells lose sessile epithelial traits and acquire mesenchymal migratory potential. The mesenchymal state is also associated with cancer stem cells and resistance to chemotherapy. It might therefore be therapeutically beneficial to promote epithelial identity in cancer. Because large-scale cell identity shifts are often orchestrated on an epigenetic level, we screened for candidate epigenetic factors and identified the histone methyltransferase SUV420H2 (KMT5C) as favoring the mesenchymal identity in pancreatic cancer cell lines...
December 11, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29228745/prognostic-role-of-the-pre-treatment-platelet-lymphocyte-ratio-in-pancreatic-cancer-a-meta-analysis
#12
Zheng-Shui Xu, Fa-Peng Zhang, Yin Zhang, Yong-Peng Ou-Yang, Xiao-Wen Yu, Wen-Long Wang, Wen-Ji Xu, Zhi-Qiang Luo
Background and Aims: Recently, the pre-treatment platelet-lymphocyte ratio (PLR), which is based on blood parameters, was accepted as a prognostic factor for patients with various cancers. Numerous studies have investigated the prognostic role of the PLR in pancreatic cancer; however, it remains unclear. Therefore, we conducted this meta-analysis to evaluate the relationship between the pre-treatment PLR and overall survival (OS) in pancreatic cancer. Materials and Methods: We performed a systematic literature search of the PubMed, Embase and Web of Science databases for relevant studies that explored the prognostic role of the pre-treatment PLR in pancreatic cancer...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226705/survival-prediction-in-pancreatic-cancer-patients-with-no-distant-metastasis-a-large-scale-population-based-estimate
#13
Ning Pu, Yang Lv, Guochao Zhao, Wanling Lee, Abulimiti Nuerxiati, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Wenchuan Wu, Wenhui Lou
AIM: To identify the risk factors for overall survival (OS) of pancreatic ductal adenocarcinoma patients with no distant metastasis, and formulate a novel nomogram for prognostic prediction. PATIENTS & METHODS: Data were obtained from Surveillance, Epidemiology, and End Results database of pancreatic ductal adenocarcinoma patients with no distant metastasis as the primary cohort, and 127 patients at our institution were enrolled as the validation cohort. The prognostic nomogram integrating all independent risk factors for predicting OS was established to achieve superior discriminatory ability...
December 11, 2017: Future Oncology
https://www.readbyqxmd.com/read/29217490/evaluation-of-pancreatic-exocrine-insufficiency-by-cine-dynamic-mrcp-using-spatially-selective-inversion-recovery-ir-pulse-correlation-with-severity-of-chronic-pancreatitis-based-on-morphological-changes-of-pancreatic-duct
#14
Kazuya Yasokawa, Katsuyoshi Ito, Akihiko Kanki, Akira Yamamoto, Teruyuki Torigoe, Tomohiro Sato, Tsutomu Tamada
PURPOSE: To evaluate the correlation between the pancreatic exocrine insufficiency estimated by cine-dynamic MRCP using spatially selective IR pulse and the severity stages (modified Cambridge classification) based on morphological changes of the pancreatic duct in patients with suspected chronic pancreatitis. MATERIALS AND METHODS: Thirty-nine patients with suspected chronic pancreatitis underwent cine-dynamic MRCP with a spatially selective IR pulse. The secretion grading score (5-point scale) based on the moving distance of pancreatic juice inflow on cine-dynamic MRCP was assessed, and compared with the stage of the severity of chronic pancreatitis based on morphological changes of pancreatic duct...
December 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29212273/repositioning-cep-1347-a-chemical-agent-originally-developed-for-the-treatment-of-parkinson-s-disease-as-an-anti-cancer-stem-cell-drug
#15
Masashi Okada, Hiroyuki Takeda, Hirotsugu Sakaki, Kenta Kuramoto, Shuhei Suzuki, Tomomi Sanomachi, Keita Togashi, Shizuka Seino, Chifumi Kitanaka
CEP-1347 is a mixed lineage kinase inhibitor tested in a large-scale phase 2/3 clinical trial in early Parkinson's disease, in which its safety and tolerability, but nevertheless not efficacy, was demonstrated. Here we identify by drug repositioning CEP-1347 as a potential anti-cancer stem cell drug. In vitro, CEP-1347 efficiently induced differentiation and inhibited the self-renewal and tumor-initiating capacities of human cancer stem cells from glioblastoma as well as from pancreatic and ovarian cancers at clinically-relevant concentrations, without impairing the viability of normal fibroblasts and neural stem cells...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211787/the-effect-of-somatostatin-analogues-on-postoperative-outcomes-following-pancreatic-surgery-a-meta-analysis
#16
Xianlin Han, Zhiyan Xu, Shaobo Cao, Yupei Zhao, Wenming Wu
BACKGROUND: Leakage from the pancreatic stump is a leading cause of morbidity following pancreatic surgery. It is essential to evaluate the effect of somatostatin analogues (SAs) following pancreatic surgery by analyzing all recent clinical trials. DATA SOURCES: We performed a literature search in the Medline, EMBASE, Cochrane Central Register of Controlled Trials and Web of Science databases up to May 29, 2016. Publication bias was assessed with Egger's test. Study quality was assessed using the Jadad Composite Scale...
2017: PloS One
https://www.readbyqxmd.com/read/29209119/how-severe-is-moderately-severe-acute-pancreatitis-clinical-validation-of-revised-2012-atlanta-classification
#17
Povilas Ignatavicius, Aiste Gulla, Karolis Cernauskis, Giedrius Barauskas, Zilvinas Dambrauskas
AIM: To explore the outcomes and the appropriate treatment for patients with moderately severe acute pancreatitis (AP). METHODS: Statistical analysis was performed on data from the prospectively collected database of 103 AP patients admitted to the Department of Surgery, Hospital of Lithuanian University of Health Sciences in 2008-2013. All patients were confirmed to have the diagnosis of AP during the first 24 h following admission. The severity of pancreatitis was assessed by MODS and APACHE II scale...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29193572/incretin-based-therapies-and-risk-of-pancreatic-cancer-in-patients-with-type-2-diabetes-a-meta-analysis-of-randomised-controlled-trials
#18
Haining Wang, Ye Liu, Qing Tian, Jin Yang, Ran Lu, Siyan Zhan, Jari Haukka, Tianpei Hong
AIMS: Conflicting evidence exists regarding the potential risk of pancreatic cancer with use of incretin drugs in patients with type 2 diabetes (T2DM). We performed a meta-analysis of randomised controlled trials (RCTs), including six recently published large-scale cardiovascular outcome trials (CVOTs), to evaluate the risk of pancreatic cancer with incretin-based therapies in patients with T2DM. MATERIALS AND METHODS: The PubMed, Embase, Cochrane Central Register and ClininalTrials...
November 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29190982/diagnostic-performance-enhancement-of-pancreatic-cancer-using-proteomic-multimarker-panel
#19
Jiyoung Park, Yonghwan Choi, Junghyun Namkung, Sung Gon Yi, Hyunsoo Kim, Jiyoung Yu, Yongkang Kim, Min-Seok Kwon, Wooil Kwon, Do-Youn Oh, Sun-Whe Kim, Seung-Yong Jeong, Wonshik Han, Kyu Eun Lee, Jin Seok Heo, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Chang Moo Kang, Woo Jin Lee, Seungyeoun Lee, Sangjo Han, Taesung Park, Jin-Young Jang, Youngsoo Kim
Due to its high mortality rate and asymptomatic nature, early detection rates of pancreatic ductal adenocarcinoma (PDAC) remain poor. We measured 1000 biomarker candidates in 134 clinical plasma samples by multiple reaction monitoring-mass spectrometry (MRM-MS). Differentially abundant proteins were assembled into a multimarker panel from a training set (n=684) and validated in independent set (n=318) from five centers. The level of panel proteins was also confirmed by immunoassays. The panel including leucine-rich alpha-2 glycoprotein (LRG1), transthyretin (TTR), and CA19-9 had a sensitivity of 82...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29188108/ultrahigh-resolution-optical-coherence-elastography-through-a-micro-endoscope-towards-in-vivo-imaging-of-cellular-scale-mechanics
#20
Qi Fang, Andrea Curatolo, Philip Wijesinghe, Yen Ling Yeow, Juliana Hamzah, Peter B Noble, Karol Karnowski, David D Sampson, Ruth Ganss, Jun Ki Kim, Woei M Lee, Brendan F Kennedy
In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating a gradient-index (GRIN)-lens micro-endoscope into an ultrahigh-resolution optical coherence elastography system. The optical system, after the endoscope, has a lateral resolution of 1.6 µm and an axial resolution of 2.2 µm. Bessel beam illumination and Gaussian mode detection are used to provide an extended depth-of-field of 80 µm, which is a 4-fold improvement over a fully Gaussian beam case with the same lateral resolution...
November 1, 2017: Biomedical Optics Express
keyword
keyword
86499
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"