keyword
MENU ▼
Read by QxMD icon Read
search

pancreatitis scales

keyword
https://www.readbyqxmd.com/read/28636047/decoding-the-regulatory-mechanism-of-glucose-and-insulin-induced-phosphatidylinositol-3-4-5-trisphosphate-dynamics-in-%C3%AE-cells
#1
Tagari Samanta, Peeyush Sharma, Dwijendra Kukri, Sandip Kar
In MIN6 pancreatic β-cells, glucose and insulin act in a synergistic manner to regulate the dynamics of Phosphatidylinositol (3,4,5)-trisphosphate (PIP3). However, the precise regulatory mechanism behind such an experimentally observed synergy is poorly understood. In this article, we propose a phenomenological mathematical model for studying the glucose and insulin driven PIP3 activation dynamics under various stimulatory conditions to unfold the mechanism responsible for the observed synergy. The modeling study reveals that the experimentally observed oscillation in PIP3 dynamics with disparate time scales for different external glucose doses is mainly orchestrated by the complex dynamic regulation of cytosolic Ca(2+) in β-cells...
June 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28635615/topography-on-a-subcellular-scale-modulates-cellular-adhesions-and-actin-stress-fiber-dynamics-in-tumor-associated-fibroblasts
#2
Mikheil Azatov, Xiaoyu Sun, Alexandra Suberi, John T Fourkas, Arpita Upadhyaya
Cells can sense and adapt to mechanical properties of their environment. The local geometry of the extracellular matrix, such as its topography, has been shown to modulate cell morphology, migration, and proliferation. Here we investigate the effect of micro/nanotopography on the morphology and cytoskeletal dynamics of human pancreatic tumor-associated fibroblast cells (TAFs). We use arrays of parallel nanoridges with variable spacings on a subcellular scale to investigate the response of TAFs to the topography of their environment...
June 21, 2017: Physical Biology
https://www.readbyqxmd.com/read/28631495/serum-endocannabinoids-in-assessing-pain-in-patients-with-chronic-pancreatitis-and-in-those-with-pancreatic-ductal-adenocarcinoma
#3
Raffaele Pezzilli, Pierangela Ciuffreda, Roberta Ottria, Alessandro Ravelli, Gianvico Melzi d'Eril, Alessandra Barassi
BACKGROUND: The endocannabinoid system plays a substantial role in analgesia. AIM: To analyze N-arachidonoylethanolamine (AEA), N-oleoylethanolamine (OEA), linoleoyl ethanolamide (LEA), α-linoleoyl ethanolamine (α-LNEA), N-palmitoylethanolamine (PEA) and N-stearoyl ethanolamine (SEA) in two groups of patients having chronic pancreatic diseases. PATIENTS AND METHODS: Twenty-six patients with chronic pancreatitis, 26 patients with pancreatic ductal adenocarcinoma and 36 healthy subjects were studied...
June 20, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28628722/microscopic-lymphovascular-invasion-is-an-independent-predictor-of-survival-in-resected-pancreatic-ductal-adenocarcinoma
#4
Jeffrey D Epstein, Geoffrey Kozak, Zhi Ven Fong, Jin He, Ammar A Javed, Upasana Joneja, Wei Jiang, Cristina R Ferrone, Keith D Lillemoe, John L Cameron, Matthew J Weiss, Harish Lavu, Charles J Yeo, Carlos Fernandez-Del Castillo, Christopher L Wolfgang, Jordan M Winter
Background and Objectives Despite routine inclusion of lymphovascular invasion (LVI) status in pathologic reports of resected pancreatic ductal adenocarcinomas (PDA), the clinical implications of LVI have not been well characterized. Methods This study is a retrospective review of 2640 patients who underwent a pancreatectomy for PDA at Thomas Jefferson University Hospital, Massachusetts General Hospital, or Johns Hopkins Hospital (2003-2014). Clinical and pathologic records were extracted from institutional databases...
June 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28627758/spectral-library-based-glycopeptide-analysis-detection-of-circulating-galectin-3-binding-protein-in-pancreatic-cancer
#5
Eslam N Nigjeh, Ru Chen, Yasuko Allen-Tamura, Randall E Brand, Teresa A Brentnall, Sheng Pan
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by its late diagnosis, poor prognosis and rapid development of drug resistance. Using the data independent acquisition (DIA) technique, we applied a spectral library-based proteomic approach to analyze N-glycosylated peptides in human plasma, in the context of pancreatic cancer study. EXPERIMENTAL DESIGN: We extended the application of DIA to the quantification of N-glycosylated peptides enriched from plasma specimens from a clinically well-defined cohort that consists of patients with early stage PDAC, chronic pancreatitis and healthy subjects...
June 19, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28625958/pain-management-of-pancreatic-cancer-patients-with-high-intensity-focused-ultrasound-therapy
#6
Yulan Shi, Xiao Ying, Xiaoye Hu, Hong Shen
This study was performed to evaluate cancer pain control of high-Intensity focused ultrasound ablation (HIFU) and to manage the HIFU treatment pain in advanced pancreatic cancer patients with analgesics. We collected 71 locally advanced pancreatic cancer patients treated with HIFU from 2013 March to 2014 January in our hospital. The cancer pain (pre-HIFU and two weeks after HIFU) and HIFU treatment pain were evaluated respectively. The numeric rating scale (NRS) was used as the tool of pain evaluation. The related factors with pains were analyzed...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28621298/is-the-stella%C3%A2-5l-system-an-effective-cold-sterilization-technique-for-needle-based-confocal-miniprobes
#7
Cai-Xia Wang, Yuan-Yuan Chen, Feng Yang, Fan Yang, Jin-Tao Guo, Siyu Sun, Ling Fan
BACKGROUND AND OBJECTIVE: Needle-based confocal laser endomicroscopy (nCLE) under endoscopic ultrasound guidance is a newly developed imaging technique for pancreatic lesions and lymph nodes, enabling a subcellular level of resolution. The confocal miniprobe is an invasive instrument designed to be reused up to 10 times. Therefore, a method that ensures the complete elimination of microbial contaminants on the device is necessary. We studied the bactericidal efficacy of the Stella™ system, which purports to achieve this objective...
May 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28603672/chemical-composition-and-the-potential-for-proteomic-transformation-in-cancer-hypoxia-and-hyperosmotic-stress
#8
Jeffrey M Dick
The changes of protein expression that are monitored in proteomic experiments are a type of biological transformation that also involves changes in chemical composition. Accompanying the myriad molecular-level interactions that underlie any proteomic transformation, there is an overall thermodynamic potential that is sensitive to microenvironmental conditions, including local oxidation and hydration potential. Here, up- and down-expressed proteins identified in 71 comparative proteomics studies were analyzed using the average oxidation state of carbon (ZC) and water demand per residue ([Formula: see text]), calculated using elemental abundances and stoichiometric reactions to form proteins from basis species...
2017: PeerJ
https://www.readbyqxmd.com/read/28602879/prognostic-role-of-pretreatment-blood-neutrophil-to-lymphocyte-ratio-in-advanced-cancer-survivors-a-systematic-review-and-meta-analysis-of-66-cohort-studies
#9
REVIEW
Zubing Mei, Lu Shi, Bo Wang, Jizhen Yang, Zhihong Xiao, Peixin Du, Qingming Wang, Wei Yang
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) is crucial for the incidence and mortality of various tumors. However, little is known on NLR and its association with prognosis in advanced tumors. Here we performed a meta-analysis to establish the prognostic significance of pretreatment blood NLR for advanced tumors. METHODS: A systematic literature search through April 2016 was performed to evaluate the association between pretreatment blood NLR and overall survival (OS) or progression-free survival (PFS) in patients with advanced tumors...
May 29, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28596059/development-and-validation-of-a-pancreatic-injury-mortality-score-pims-based-on-473-consecutive-patients-treated-at-a-level-1-trauma-center
#10
Jake E Krige, Richard T Spence, Pradeep H Navsaria, Andrew J Nicol
BACKGROUND: This study sought to develop a pancreatic injury mortality score (PIMS) to identify patients at greatest risk of in-hospital mortality after a major pancreatic injury. METHODS: The study used data from a prospective database of 473 patients treated for pancreatic injuries between January 1990 and December 2015. Two thirds of the patients were assigned to the derivation cohort and one third to the validation cohort. Clinical correlates of in-hospital death were identified and considered in stepwise logistic regression analyses that identified the factors included in the risk index...
April 17, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28584505/management-and-outcome-of-patients-with-pancreatic-trauma
#11
Ravinder Pal Singh, Anuj Mahajan, Jaspal Singh Selhi, Nikhil Garg, Honey Chahal, Manjyot Bajwa
INTRODUCTION: Pancreatic trauma is a rare entity occurring in 0.2% of patients with blunt trauma abdomen. Once the diagnosis is made, the management of patients is dependent on multiple variables. Conservative management, suture repair, drainage, and resection have been utilized with varying degree of success. This study is aimed to evaluate the management of patients with pancreatic trauma. MATERIALS AND METHODS: This was a prospective study done in the Department of Surgery in Dayanand Medical College and Hospital where forty hemodynamically stable patients diagnosed to have pancreatic trauma on contrast-enhanced computed tomography abdomen were included in the study...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/28561845/dynamic-properties-of-the-growth-hormone-releasing-hormone-receptor-ghrhr-and-molecular-determinants-of-ghrh-binding
#12
M-T Matsoukas, G A Spyroulias
The growth hormone-releasing hormone receptor (GHRHR) is a member of the class B GPCR subfamily. GHRH, a 44-residue neuropeptide produced in the hypothalamus, regulates the secretion of growth hormone through its binding to GHRHR. It has recently been associated with several types of cancer such as prostate, breast, pancreatic and ovarian cancer. Family B GPCR peptides bind in a two-step model, where first the C-terminal region of the peptide interacts with the extracellular domain (ECD) of the receptor and subsequently, the N-terminal interacts with the seven transmembrane domain (TMD), resulting in activation...
May 31, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28548941/withdrawn-prognostic-role-of-anti-diabetic-drugs-in-pancreatic-cancer-a-systematic-review-and-meta-analysis
#13
Lei Zheng, Shinan Yin, Fenghua Yao, Hua Bai, Danqing Jing
Ahead of Print article withdrawn by publisher.
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537561/prediction-of-acute-pancreatitis-in-the-earliest-stages-role-of-biochemical-parameters-and-histopathological-changes
#14
Jacek Baj, Elżbieta Radzikowska, Marcin Maciejewski, Andrzej Dąbrowski, Kamil Torres
For many years, there has been a search for a set of biochemical parameters that could facilitate the assessment of severity, prognosis, and administration of early and appropriate treatment in acute pancreatitis. Administration of treatment within the first 48 hours since admission is associated with many problems of distinguishing patients with a mild form of acute pancreatitis (AP) from those with a severe form of acute pancreatitis. STUDY AIM: To assess the relationship between the extent of change in the concentration of 10 selected biochemical indicators: amylase, lipase, total bilirubin, creatinine, uric acid, aspartate transaminase, alanine transaminase, glucose, magnesium, and iron and histopathological lesions in the pancreas within 2 and 6 hours since induction of AP...
April 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28514751/large-scale-clinical-validation-of-biomarkers-for-pancreatic-cancer-using-a-mass-spectrometry-based-proteomics-approach
#15
Jisook Park, Eunjung Lee, Kyoung-Jin Park, Hyung-Doo Park, Jong-Won Kim, Hye In Woo, Kwang Hyuck Lee, Kyu-Taek Lee, Jong Kyun Lee, Joon-Oh Park, Young Suk Park, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Kee-Taek Jang, Soo-Youn Lee
We performed an integrated analysis of proteomic and transcriptomic datasets to develop potential diagnostic markers for early pancreatic cancer. In the discovery phase, a multiple reaction monitoring assay of 90 proteins identified by either gene expression analysis or global serum proteome profiling was established and applied to 182 clinical specimens. Nine proteins (P < 0.05) were selected for the independent validation phase and quantified using stable isotope dilution-multiple reaction monitoring-mass spectrometry in 456 specimens...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28506431/usefulness-of-three-dimensional-magnetic-resonance-cholangiopancreatography-with-partial-maximum-intensity-projection-for-diagnosing-autoimmune-pancreatitis
#16
Shin Yanagisawa, Yasunari Fujinaga, Takayuki Watanabe, Masahiro Maruyama, Takashi Muraki, Masaaki Takahashi, Akira Fujita, Sachie Fujita, Masahiro Kurozumi, Kazuhiko Ueda, Hideaki Hamano, Shigeyuki Kawa, Masumi Kadoya
PURPOSE: To compare three-dimensional magnetic resonance cholangiopancreatography (MRCP) with/without partial maximum intensity projection (MIP) and endoscopic retrograde cholangiopancreatography (ERCP) in patients with autoimmune pancreatitis (AIP). MATERIALS AND METHODS: Three-dimensional MRCP and ERCP images were retrospectively analyzed in 24 patients with AIP. We evaluated the narrowing length of the main pancreatic duct (NR-MPD), multiple skipped MPD narrowing (SK-MPD), and side branches arising from the narrowed portion of the MPD (SB-MPD) using four MRCP datasets: 5 original images (MIP5), 10 original images (MIP10), all original images (full-MIP), and a combination of these three datasets (a-MIP)...
May 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28486485/hydrogen-peroxide-inhibition-of-bicupin-oxalate-oxidase
#17
John M Goodwin, Hassan Rana, Joan Ndungu, Gaurab Chakrabarti, Ellen W Moomaw
Oxalate oxidase is a manganese containing enzyme that catalyzes the oxidation of oxalate to carbon dioxide in a reaction that is coupled with the reduction of oxygen to hydrogen peroxide. Oxalate oxidase from Ceriporiopsis subvermispora (CsOxOx) is the first fungal and bicupin enzyme identified that catalyzes this reaction. Potential applications of oxalate oxidase for use in pancreatic cancer treatment, to prevent scaling in paper pulping, and in biofuel cells have highlighted the need to understand the extent of the hydrogen peroxide inhibition of the CsOxOx catalyzed oxidation of oxalate...
2017: PloS One
https://www.readbyqxmd.com/read/28473337/impact-of-liraglutide-on-amylase-lipase-and-acute-pancreatitis-in-participants-with-overweight-obesity-and-normoglycemia-prediabetes-or-type-2-diabetes-secondary-analyses-of-pooled-data-from-the-scale-clinical-development-program
#18
William M Steinberg, Julio Rosenstock, Thomas A Wadden, Morten Donsmark, Christine B Jensen, J Hans DeVries
OBJECTIVE: To describe amylase/lipase activity levels and events of acute pancreatitis (AP) in the SCALE (Satiety and Clinical Adiposity-Liraglutide Evidence in individuals with and without diabetes) weight-management trials. RESEARCH DESIGN AND METHODS: Secondary analyses were performed on pooled data from four trials (N = 5,358 with BMI ≥30, or 27 to <30 kg/m(2) with ≥1 comorbidity). Of these, 1,723 had normoglycemia, 2,789 had prediabetes, and 846 had type 2 diabetes...
May 4, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28465532/demonstration-of-interposed-modular-hydrogel-sheet-for-multicellular-analysis-in-a-microfluidic-assembly-platform
#19
Chae Yun Bae, Jaejung Son, Hail Kim, Je-Kyun Park
Hydrogel sheets have emerged as a promising biomaterial scaffold for the encapsulation and transfer of multicellular structures. Although the improvement of the chemical interactions and the design of micro-scaled geometry have contributed to the development of multipurpose hydrogel scaffolds, the application of hydrogel sheets to assess multicellular structures is still challenging. To expand the technical applicability of hydrogel sheets, we here demonstrate that a single layer of the hydrogel sheet can be integrated as an interposed module in a microfluidic device for multicellular analysis...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28462883/effectiveness-of-contrast-enhanced-ultrasound-for-the-diagnosis-of-acute-pancreatitis-a-systematic-review-and-meta-analysis
#20
REVIEW
Yang Fei, Wei-Qin Li
OBJECTIVE: To systematically determine the diagnostic value of contrast-enhanced ultrasound (CEUS) in the assessment of acute pancreatitis. METHODS: Relevant studies were identified by searching the database up to December 2016. Patient clinical characteristics and diagnostic sensitivity and specificity were extracted. The summary receiver operating characteristic (ROC) curve was used to examine the accuracy of CEUS. A meta-analysis was performed to evaluate the clinical utility in the diagnosis and evaluation of acute pancreatitis...
June 2017: Digestive and Liver Disease
keyword
keyword
86499
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"