keyword
MENU ▼
Read by QxMD icon Read
search

Brown fat PET

keyword
https://www.readbyqxmd.com/read/29704560/identification-of-an-optimal-threshold-for-detecting-human-brown-adipose-tissue-using-receiver-operating-characteristic-analysis-of-ideal-mri-fat-fraction-maps
#1
Terence A Jones, Sarah C Wayte, Narendra L Reddy, Oludolapo Adesanya, George K Dimitriadis, Thomas M Barber, Charles E Hutchinson
PURPOSE: Lower fat fraction (FF) in brown adipose tissue (BAT) than white adipose tissue (WAT) has been exploited using Dixon-based Magnetic Resonance Imaging (MRI) to differentiate these tissues in rodents, human infants and adults. We aimed to determine whether an optimal FF threshold could be determined to differentiate between BAT and WAT in adult humans in vivo. METHODS: Sixteen volunteers were recruited (9 females, 7 males; 44.2 ± 19.2 years) based on BAT uptake on 18 F-FDG PET/CT...
April 25, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29643685/unilateral-brown-fat-suppression-on-fdg-pet-ct-detecting-sympathetic-denervation
#2
Saurabh Arora, Nishikant Avinash Damle, K Sreenivasa Reddy, Girish Kumar Parida, Abhinav Singhal, Sreedharan Thankarajan Arunraj, Chandrasekhar Bal, Roma Singh, Shobhana Raju, Dhritiman Chakraborty
We present here a case of primitive neuroectodermal tumor (PNET) who initially presented with involvement of the right 3rd rib and underwent neoadjuvant chemotherapy, rib excision, and adjuvant chemoradiotherapy and later underwent posterolateral thoracotomy, pleural nodule excision, and the right 11th rib metastatic lesion excision. Follow-up 18 F-FDG PET/CT/computed tomography revealed unilateral brown fat suppression in the form of decreased metabolic uptake in the ipsilateral cervical, axillary, and paravertebral brown fat as compared to metabolically active contralateral brown fat, likely due to paravertebral sympathetic chain damage...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29449935/pleomorphic-liposarcoma-of-bone-a-rare-primary-malignant-bone-tumour
#3
G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29438845/-brain-over-body-a-study-on-the-willful-regulation-of-autonomic-function-during-cold-exposure
#4
Otto Muzik, Kaice T Reilly, Vaibhav A Diwadkar
The defense of body temperature against environmental thermal challenges is a core objective of homeostatic regulation governed by the autonomic nervous system. Autonomous mechanisms of thermoregulation are only weakly affected by top-down modulation, allowing only transient tolerance for extreme cold. There is however, anecdotal evidence of a unique set of individuals known for extreme cold tolerance. Here we present a case study of a 57-year old Dutch national, Wim Hof, the so-called "Iceman", with the ability to withstand frequent prolonged periods of extreme cold exposure based on the practice of a self-developed technique involving a combination of forced breathing, cold exposure and meditation (collectively referred to as the Wim Hof Method, henceforth "WHM")...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29381803/capsinoids-activate-brown-adipose-tissue-bat-with-increased-energy-expenditure-associated-with-subthreshold-18-fluorine-fluorodeoxyglucose-uptake-in-bat-positive-humans-confirmed-by-positron-emission-tomography-scan
#5
Lijuan Sun, Stefan G Camps, Hui Jen Goh, Priya Govindharajulu, Joshua D Schaefferkoetter, David W Townsend, Sanjay K Verma, S Sendhil Velan, Lei Sun, Siu Kwan Sze, Su Chi Lim, Bernhard Otto Boehm, Christiani Jeyakumar Henry, Melvin Khee-Shing Leow
Background: Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). Objective: We compared capsinoids and cold exposure on BAT activation and whole-body EE...
January 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29377423/brown-adipose-tissue-lipid-metabolism-in-morbid-obesity-effect-of-bariatric-surgery-induced-weight-loss
#6
Prince Dadson, Jarna C Hannukainen, Mueez U Din, Minna Lahesmaa, Kari K Kalliokoski, Patricia Iozzo, Jussi Pihlajamäki, Henry K Karlsson, Riitta Parkkola, Paulina Salminen, Kirsi A Virtanen, Pirjo Nuutila
OBJECTIVE: We aimed to investigate the effect of bariatric surgery on lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women. We hypothesized that lipid metabolism improves after surgery-induced weight loss. MATERIALS AND METHODS: A total of 23 morbidly obese women (BMI, 42.1 ± 4.2 kg/m2 ; age, 43.8 ± 9.8 years) were assessed before and 6 months after bariatric surgery and 15 age- and sex-matched controls (22.6 ± 2.8 kg/m2 ) were assessed once...
May 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29320705/an-adipose-tissue-atlas-an-image-guided-identification-of-human-like-bat-and-beige-depots-in-rodents
#7
Fang Zhang, Guiyang Hao, Mengle Shao, Kien Nham, Yu An, Qiong Wang, Yi Zhu, Christine M Kusminski, Gedaa Hassan, Rana K Gupta, Qiwei Zhai, Xiankai Sun, Philipp E Scherer, Orhan K Oz
[18 F]Fluorodeoxyglucose-PET/CT (18 F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as 18 F-FDG through PET/CT or [123/125 I]-β-methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads...
January 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29196742/whitening-and-impaired-glucose-utilization-of-brown-adipose-tissue-in-a-rat-model-of-type-2-diabetes-mellitus
#8
Constantin Lapa, Paula Arias-Loza, Nobuyuki Hayakawa, Hiroshi Wakabayashi, Rudolf A Werner, Xinyu Chen, Tetsuya Shinaji, Ken Herrmann, Theo Pelzer, Takahiro Higuchi
Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by18 F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119565/non-invasive-methods-for-the-assessment-of-brown-adipose-tissue-in-humans
#9
Maria Chondronikola, Scott C Beeman, Richard L Wahl
Brown adipose tissue (BAT) is a recently rediscovered tissue in people that has shown promise as a potential therapeutic target against obesity and its metabolic abnormalities. Reliable non-invasive assessment of BAT volume and activity is critical to allow its importance in metabolic control to be evaluated. Positron emission tomography/computed tomography (PET/CT) in combination with 2-deoxy-2-[18 F]fluoroglucose administration is currently the most frequently used and most established method for the detection and quantification of activated BAT in humans...
February 1, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29108812/correlation-of-brown-adipose-tissue-with-other-body-fat-compartments-and-patient-characteristics-a-retrospective-analysis-in-a-large-patient-cohort-using-pet-ct
#10
Cornelia Brendle, Matthias K Werner, Maria Schmadl, Christian la Fougère, Konstantin Nikolaou, Norbert Stefan, Christina Pfannenberg
RATIONALE AND OBJECTIVES: The objective of this study was to assess the relationship of brown adipose tissue (BAT) activity with different fat compartments of the body, body mass index (BMI), outdoor temperature, thyroid-stimulating hormone (TSH) levels, blood glucose, age, and sex in a large patient population using F-18-fluordesoxyglucose positron emission tomography-computer tomography (FDG-PET/CT) scans obtained under thermoneutral conditions. MATERIALS AND METHODS: FDG-PET/CT scans of 4852 patients were retrospectively analyzed for BAT activity...
January 2018: Academic Radiology
https://www.readbyqxmd.com/read/29021924/large-unilateral-adrenal-mass-with-surrounding-brown-fat-a-case-report
#11
Gabriel O Ologun, Zinal M Patel, Navpreet K Rana, Andrew Trecartin, Alice Shen, Douglas Trostle, David Bertsch
Pheochromocytomas are rare tumors derived from chromaffin cells located in the adrenal and extra adrenal tissues. Pheochromocytomas are diagnosed biochemically and localized using different imaging modalities. The definitive management is surgical resection. Brown adipose tissues are normally present during fetal development, with regression over time. Brown adipose tissues are thermogenic and usually located in the neck, mediastinum, and retroperitoneum. Here, we report a case of a unilateral pheochromocytoma surrounded by brown fat...
August 9, 2017: Curēus
https://www.readbyqxmd.com/read/28983743/pet-imaging-of-human-brown-adipose-tissue-with-the-tspo-tracer-11-c-pbr28
#12
Chongzhao Ran, Daniel S Albrecht, Miriam A Bredella, Jing Yang, Jian Yang, Steven H Liang, Aaron M Cypess, Marco L Loggia, Nazem Atassi, Anna Moore
PURPOSE: Brown adipose tissue (BAT) in adult humans has been recently rediscovered and intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes (T2D). However, reliable assessment of BAT mass in vivo represents a considerable challenge. The purpose of this investigation is to demonstrate for the first time that human BAT depots can be imaged with a translocator protein (TSPO)-specific positron emission tomography (PET) tracer [(11)C]PBR28 under thermoneutral conditions...
October 5, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28935898/pd-l1-is-an-activation-independent-marker-of-brown-adipocytes
#13
Jessica R Ingram, Michael Dougan, Mohammad Rashidian, Marko Knoll, Edmund J Keliher, Sarah Garrett, Scott Garforth, Olga S Blomberg, Camilo Espinosa, Atul Bhan, Steven C Almo, Ralph Weissleder, Harvey Lodish, Stephanie K Dougan, Hidde L Ploegh
Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid single-domain antibody (anti-PD-L1 VHH) to track PD-L1 expression by immuno-positron emission tomography (PET). PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes and demonstrate that signal intensity does not change in response to cold exposure or β-adrenergic activation...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28853013/effects-of-bariatric-surgery-on-change-of-brown-adipocyte-tissue-and-energy-metabolism-in-obese-mice
#14
Yuanwen Chen, Jianjun Yang, Xin Nie, Zhicheng Song, Yan Gu
BACKGROUND: Bariatric surgery is an effective treatment for obesity causing changes in energy expenditure. Brown adipose tissue (BAT) is an energy-related organ, and the potential effects of bariatric surgery are yet to be investigated. We aimed to study the effects of different bariatric surgeries on growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, brown adipocyte differentiation, and energy metabolism in obese mice and explore the underlying mechanisms. METHODS: Mice were fed a high-fat diet for 12 weeks and subjected to different bariatric procedures: adjustable gastric band (AGB), sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and sham operation (SO)...
March 2018: Obesity Surgery
https://www.readbyqxmd.com/read/28801960/mri-characterization-of-brown-adipose-tissue-under-thermal-challenges-in-normal-weight-overweight-and-obese-young-men
#15
Jie Deng, Lisa M Neff, Nicholas C Rubert, Bin Zhang, Richard M Shore, Jonathan D Samet, Paige C Nelson, Lewis Landsberg
PURPOSE: To implement quantitative Dixon magnetic resonance imaging (MRI) methods for brown adipose tissue (BAT) characterization at inactive and cold-activated states in normal weight, overweight, and obese subjects. The hypotheses are that MRI characteristics of BAT would differentiate between nonobese and obese subjects, and activation of BAT in response to thermal challenges that are detected by MRI would be correlated with BAT activity measured by positron emission tomography / computed tomography (PET/CT)...
April 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28629569/in-depth-analysis-of-interreader-agreement-and-accuracy-in-categorical-assessment-of-brown-adipose-tissue-in-18-fdg-pet-ct
#16
Anton S Becker, Caroline Zellweger, Khoschy Schawkat, Sanja Bogdanovic, Valerie Doan Phi van, Hannes W Nagel, Christian Wolfrum, Irene A Burger
PURPOSE: To evaluate the interreader agreement of a three-tier craniocaudal grading system for brown fat activation and investigate the accuracy of the distinction between the three grades. MATERIALS AND METHODS: After IRB approval, 340 cases were retrospectively selected from patients undergoing (18)FDG-PET/CT between 2007 and 2015 at our institution, with 85 cases in each grade and 85 controls with no active brown fat. Three readers evaluated all cases independently...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28590773/factors-influencing-brown-fat-activation-in-fdg-pet-ct-a-retrospective-analysis-of-15-000-cases
#17
Jeffrey D Steinberg, Wouter Vogel, Erik Vegt
OBJECTIVE: Brown fat can exhibit high uptake of fluorine-18 fludeoxyglucose ((18)F-FDG) on positron emission tomography (PET) and interferes with interpretation of the scan. The goal of this study was to identify factors that may influence brown adipose tissue (BAT) activation. METHODS: A retrospective study of (18)F-FDG PET scans was performed using a database of 15,109 PET/CT reports. BAT activation reported by nuclear medicine physicians and factors influencing BAT activation were gathered...
July 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28588036/brown-fat-depots-in-adult-humans-remain-static-in-their-locations-on-pet-ct-despite-changes-in-seasonality
#18
Terence A Jones, Narendra L Reddy, Sarah C Wayte, Oludolapo Adesanya, Georgios K Dimitriadis, Charles E Hutchinson, Thomas M Barber
Active brown adipose tissue (BAT) in humans has been demonstrated through use of positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose integrated with computed tomography ((18)F-FDG PET/CT) scans. The aim of our study was to determine whether active human BAT depots shown on (18)F-FDG PET/CT scans remain static in their location over time. This was a retrospective study. Adult human subjects (n = 15) who had had (18)F-FDG PET/CT imaging (n = 38 scans in total) for clinical reasons were included on the basis of (18)F-FDG uptake patterns consistent with BAT activity...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28580427/incidental-finding-of-low-brown-adipose-tissue-activity-in-endurance-trained-individuals-methodological-considerations-for-positron-emission-tomography
#19
Eric T Trexler, Drew McCallister, Abbie E Smith-Ryan, Rosa T Branca
Brown adipose tissue (BAT) in adults has been shown to have a meaningful impact on energy expenditure and cold-induced thermogenesis. Data from rodent research have suggested that exercise may be a promising method of increasing BAT activity, with potential applications to the treatment and prevention of obesity and diabetes. However, emerging human research using positron emission tomography (PET) with [18F] Fluorodeoxyglucose (FDG) has identified lower BAT activity in endurance-trained athletes compared to sedentary controls, despite similar metabolic rate responses to cold exposure...
March 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28509766/brown-adipose-tissue-detected-by-pet-ct-imaging-is-associated-with-less-central-obesity
#20
Aileen L Green, Ulas Bagci, Sarfaraz Hussein, Patrick V Kelly, Razi Muzaffar, Brent A Neuschwander-Tetri, Medhat M Osman
PURPOSE: This retrospective review was performed to determine whether patients with brown adipose tissue (BAT) detected by fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging have less central obesity than BMI-matched control patients without detectable BAT. PATIENTS AND METHODS: Thirty-seven adult oncology patients with F-FDG BAT uptake were retrospectively identified from PET/CT studies from 2011 to 2013. The control cohort consisted of 74 adult oncology patients without detectable F-FDG BAT uptake matched for BMI/sex/season...
July 2017: Nuclear Medicine Communications
keyword
keyword
86497
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"