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Brown fat PET

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https://www.readbyqxmd.com/read/28629569/in-depth-analysis-of-interreader-agreement-and-accuracy-in-categorical-assessment-of-brown-adipose-tissue-in-18-fdg-pet-ct
#1
Anton S Becker, Caroline Zellweger, Khoschy Schawkat, Sanja Bogdanovic, Valerie Doan Phi van, Hannes W Nagel, Christian Wolfrum, Irene A Burger
PURPOSE: To evaluate the interreader agreement of a three-tier craniocaudal grading system for brown fat activation and investigate the accuracy of the distinction between the three grades. MATERIALS AND METHODS: After IRB approval, 340 cases were retrospectively selected from patients undergoing (18)FDG-PET/CT between 2007 and 2015 at our institution, with 85 cases in each grade and 85 controls with no active brown fat. Three readers evaluated all cases independently...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28590773/factors-influencing-brown-fat-activation-in-fdg-pet-ct-a-retrospective-analysis-of-15-000-cases
#2
Jeffrey D Steinberg, Wouter Vogel, Erik Vegt
OBJECTIVES: Brown fat can exhibit high uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) on positron emission tomography (PET) and interfere with interpretation of the scan. The goal of this study was to identify factors that may influence BAT activation. METHODS: A retrospective study of FDG PET scans was performed using a database of 15,109 PET/CT reports. BAT activation reported by nuclear medicine physicians and factors influencing BAT activation were gathered...
June 7, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28588036/brown-fat-depots-in-adult-humans-remain-static-in-their-locations-on-pet-ct-despite-changes-in-seasonality
#3
Terence A Jones, Narendra L Reddy, Sarah C Wayte, Oludolapo Adesanya, Georgios K Dimitriadis, Charles E Hutchinson, Thomas M Barber
Active brown adipose tissue (BAT) in humans has been demonstrated through use of positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose integrated with computed tomography ((18)F-FDG PET/CT) scans. The aim of our study was to determine whether active human BAT depots shown on (18)F-FDG PET/CT scans remain static in their location over time. This was a retrospective study. Adult human subjects (n = 15) who had had (18)F-FDG PET/CT imaging (n = 38 scans in total) for clinical reasons were included on the basis of (18)F-FDG uptake patterns consistent with BAT activity...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28580427/incidental-finding-of-low-brown-adipose-tissue-activity-in-endurance-trained-individuals-methodological-considerations-for-positron-emission-tomography
#4
Eric T Trexler, Drew McCallister, Abbie E Smith-Ryan, Rosa T Branca
Brown adipose tissue (BAT) in adults has been shown to have a meaningful impact on energy expenditure and cold-induced thermogenesis. Data from rodent research have suggested that exercise may be a promising method of increasing BAT activity, with potential applications to the treatment and prevention of obesity and diabetes. However, emerging human research using positron emission tomography (PET) with [18F] Fluorodeoxyglucose (FDG) has identified lower BAT activity in endurance-trained athletes compared to sedentary controls, despite similar metabolic rate responses to cold exposure...
March 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28509766/brown-adipose-tissue-detected-by-pet-ct-imaging-is-associated-with-less-central-obesity
#5
Aileen L Green, Ulas Bagci, Sarfaraz Hussein, Patrick V Kelly, Razi Muzaffar, Brent A Neuschwander-Tetri, Medhat M Osman
PURPOSE: This retrospective review was performed to determine whether patients with brown adipose tissue (BAT) detected by fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging have less central obesity than BMI-matched control patients without detectable BAT. PATIENTS AND METHODS: Thirty-seven adult oncology patients with F-FDG BAT uptake were retrospectively identified from PET/CT studies from 2011 to 2013. The control cohort consisted of 74 adult oncology patients without detectable F-FDG BAT uptake matched for BMI/sex/season...
May 15, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28465871/a-rare-case-of-hibernoma-occasionally-identified-by-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-patient-with-lung-cancer
#6
Daniele Penna, Natale Quartuccio, Claudio Testa, Vincenzo Arena, Angelina Cistaro, Ettore Pelosi
Hibernoma is a benign tumor arising from brown fat tissue. Conventional imaging techniques are not able to differentiate it from other benign lesions or malignant fatty tumors. We report the case of a 73-year-old patient who underwent a thorax computed tomography (CT) and was then referred to our department for metabolic assessment of a solitary lung nodule. An F18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) scan was performed and demonstrated, in addition, a highly metabolic fat-containing lesion mimicking a malignant fatty tumor in the left great pectoralis muscle...
March 29, 2017: Curēus
https://www.readbyqxmd.com/read/28417855/optimization-of-pediatric-pet-ct
#7
REVIEW
Marguerite T Parisi, Mohammed S Bermo, Adam M Alessio, Susan E Sharp, Michael J Gelfand, Barry L Shulkin
PET/CT, the most common form of hybrid imaging, has transformed oncologic imaging and is increasingly being used for nononcologic applications as well. Performing PET/CT in children poses unique challenges. Not only are children more sensitive to the effects of radiation than adults but, following radiation exposure, children have a longer postexposure life expectancy in which to exhibit adverse radiation effects. Both the PET and CT components of the study contribute to the total patient radiation dose, which is one of the most important risks of the study in this population...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28403942/mr-signal-fat-fraction-analysis-and-t2-weighted-imaging-measure-bat-reliably-on-humans-without-cold-exposure
#8
Milja Holstila, Marko Pesola, Teemu Saari, Kalle Koskensalo, Juho Raiko, Ronald J H Borra, Pirjo Nuutila, Riitta Parkkola, Kirsi A Virtanen
OBJECTIVE: Brown adipose tissue (BAT) is compositionally distinct from white adipose tissue (WAT) in terms of triglyceride and water content. In adult humans, the most significant BAT depot is localized in the supraclavicular area. Our aim is to differentiate brown adipose tissue from white adipose tissue using fat T2* relaxation time mapping and signal-fat-fraction (SFF) analysis based on a commercially available modified 2-point-Dixon (mDixon) water-fat separation method. We hypothesize that magnetic resonance (MR) imaging can reliably measure BAT regardless of the cold-induced metabolic activation, with BAT having a significantly higher water and iron content compared to WAT...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28368474/human-brown-fat-radiodensity-indicates-underlying-tissue-composition-and-systemic-metabolic-health
#9
Mueez U Din, Juho Raiko, Teemu Saari, Virva Saunavaara, Nobu Kudomi, Olof Solin, Riitta Parkkola, Pirjo Nuutila, Kirsi A Virtanen
Context: Metabolic imaging studying brown adipose tissue (BAT) physiology has increased, where computed tomography (CT) is commonly used as an anatomical reference for metabolic PET (positron emission tomography) imaging. However, the capacity of CT to provide metabolic information has been underexploited. Objective: To evaluate whether CT radiodensity of BAT could non-invasively estimate underlying tissue morphology, regarding amount of stored triglycerides. Further, could the alteration in tissue characteristics due to cold stimulus, as a marker for active BAT, be detected with radiodensity...
March 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323929/human-brown-adipose-tissue-temperature-and-fat-fraction-are-related-to-its-metabolic-activity
#10
Kalle Koskensalo, Juho Raiko, Teemu Saari, Virva Saunavaara, Olli Eskola, Pirjo Nuutila, Jani Saunavaara, Riitta Parkkola, Kirsi A Virtanen
Background and Aim: The metabolic activity of human brown adipose tissue (BAT) has been previously examined using positron emission tomography (PET). The aim of this study was to use proton magnetic resonance spectroscopy (1H MRS) to investigate whether the temperature and the fat fraction (FF) of BAT and white adipose tissue (WAT) are associated with BAT metabolic activity determined by deoxy-2-18F-fluoro-d-glucose (18F-FDG)-PET. Materials and Methods: Ten healthy subjects (four women, six men; 25 to 45 years of age) were studied using PET-magnetic resonance imaging during acute cold exposure and at ambient room temperature...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28316560/lysopc-acyl-c16-0-is-associated-with-brown-adipose-tissue-activity-in-men
#11
Mariëtte R Boon, Leontine E H Bakker, Cornelia Prehn, Jerzy Adamski, Maarten J Vosselman, Ingrid M Jazet, Lenka M Pereira Arias-Bouda, Wouter D Marken van Lichtenbelt, Ko Willems van Dijk, Patrick C N Rensen, Dennis O Mook-Kanamori
INTRODUCTION: Brown adipose tissue (BAT) recently emerged as a potential therapeutic target in the treatment of obesity and associated disorders due to its fat-burning capacity. The current gold standard in assessing BAT activity is [(18)F]FDG PET-CT scan, which has severe limitations including radiation exposure, being expensive, and being labor-intensive. Therefore, indirect markers are needed of human BAT activity and volume. OBJECTIVE: We aimed to identify metabolites in serum that are associated with BAT volume and activity in men...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28231117/compositional-analysis-of-whole-grains-processed-grains-grain-co-products-and-other-carbohydrate-sources-with-applicability-to-pet-animal-nutrition
#12
Alison N Beloshapka, Preston R Buff, George C Fahey, Kelly S Swanson
Our objective was to measure the proximate, starch, amino acid, and mineral compositions of grains, grain co-products, and other carbohydrate sources with potential use in pet foods. Thirty-two samples from barley (barley flake, cut barley, ground pearled barley, malted barley, whole pearled barley, pearled barley flakes, and steamed rolled barley); oats (groats, ground oatmeal, ground steamed groats, instant oats, oat bran, oat fiber, oat flour, quick oats, regular rolled oats, steamed rolled oat groats, and steel cut groats); rice (brown rice, polished rice, defatted rice bran, and rice flour); and miscellaneous carbohydrate sources (canary grass seed, hulled millet, whole millet, quinoa, organic spelt hull pellets, potato flake, sorghum, whole wheat, and whole yellow corn) were analyzed...
March 25, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28112821/a-pilot-study-on-the-correlation-between-fat-fraction-values-and-glucose-uptake-values-in-supraclavicular-fat-by-simultaneous-pet-mri
#13
Andrew McCallister, Le Zhang, Alex Burant, Laurence Katz, Rosa Tamara Branca
PURPOSE: To assess the spatial correlation between MRI and 18F-fludeoxyglucose positron emission tomography (FDG-PET) maps of human brown adipose tissue (BAT) and to measure differences in fat fraction (FF) between glucose avid and non-avid regions of the supraclavicular fat depot using a hybrid FDG-PET/MR scanner. METHODS: In 16 healthy volunteers, mean age of 30 and body mass index of 26, FF, R2*, and FDG uptake maps were acquired simultaneously using a hybrid PET/MR system while employing an individualized cooling protocol to maximally stimulate BAT...
January 23, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28104743/active-brown-fat-during-18fdg-pet-ct-imaging-defines-a-patient-group-with-characteristic-traits-and-an-increased-probability-of-brown-fat-redetection
#14
Carlos Gerngroß, Johanna Schretter, Martin Klingenspor, Markus Schwaiger, Tobias Fromme
Brown adipose tissue (BAT) provides a means of non-shivering thermogenesis. In humans, active BAT can be visualized by (18)F-fluoro-desoxyglucose (FDG) uptake as detected by positron emission tomography (PET) combined with computer tomography (CT). The retrospective analysis of clinical scans is a valuable source to identify anthropometric parameters that influence BAT mass and activity and thus the potential efficacy of envisioned drugs targeting this tissue to treat metabolic disease. We analyzed 2854 FDG-PET/CT scans from 1644 patients and identified 98 scans from 81 patients with active BAT...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27789721/sympathetic-innervation-of-cold-activated-brown-and-white-fat-in-lean-young-adults
#15
Otto Muzik, Tom J Mangner, William R Leonard, Ajay Kumar, James G Granneman
Recent work in rodents has demonstrated that basal activity of the local sympathetic nervous system is critical for maintaining brown adipocyte phenotypes in classic brown adipose tissue (BAT) and white adipose tissue (WAT). Accordingly, we sought to assess the relationship between sympathetic innervation and cold-induced activation of BAT and WAT in lean young adults. Methods: Twenty adult lean normal subjects (10 women and 10 men; mean age ± SD, 23.3 ± 3.8 y; body mass index, 23.7 ± 2.5 kg/m(2)) underwent (11)C-meta-hydroxyephedrin ((11)C-HED) and (15)O-water PET imaging at rest and after exposure to mild cold (16°C) temperature...
May 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27725802/preclinical-in-vivo-imaging-for-fat-tissue-identification-quantification-and-functional-characterization
#16
Pasquina Marzola, Federico Boschi, Francesco Moneta, Andrea Sbarbati, Carlo Zancanaro
Localization, differentiation, and quantitative assessment of fat tissues have always collected the interest of researchers. Nowadays, these topics are even more relevant as obesity (the excess of fat tissue) is considered a real pathology requiring in some cases pharmacological and surgical approaches. Several weight loss medications, acting either on the metabolism or on the central nervous system, are currently under preclinical or clinical investigation. Animal models of obesity have been developed and are widely used in pharmaceutical research...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27721763/hibernoma-showing-high-uniform-accumulation-on-an-18-f-fluorodeoxyglucose-positron-emission-tomography-scan-a-case-report
#17
Yasuhiro Kamata, Kazutaka Kikuta, Michiro Susa, Kazumasa Nishimoto, Aya Sasaki, Kaori Kameyama, Koji Murakami, Masaya Nakamura, Morio Matsumoto, Hideo Morioka
BACKGROUND: Hibernoma is a rare, benign, soft tissue tumor arising from brown fat that cannot be distinguished from other lipogenic tumors on computed tomography and magnetic resonance imaging (MRI) scans. On the other hand, the image of hibernoma on (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) is different from that of other lipogenic tumors. However, fewer studies have investigated the typical features of hibernoma on PET scans. We present the case of a hibernoma that was incidentally detected on (18)F-FDG-PET...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27697208/the-rediscovery-of-bat-in-adult-humans-using-imaging
#18
REVIEW
Kirsi A Virtanen
Human brown adipose tissue has been acknowledged in newborns and children but in adults the first printed publications are from the beginning of 20th century. Further evidence of the existence of adult brown fat was published throughout the century but only very recently the functionality of active brown adipose tissue in vivo in adulthood was confirmed. This was contributed mainly by advanced imaging technology, namely hybrid positron emission tomography (PET) and computed tomography (CT), being able to combine functional and anatomical imaging data...
August 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27508650/-op-3b-01-the-role-of-inflammation-in-the-arterial-aging-and-its-effects-on-the-structure-of-the-aortic-wall-heart-function-and-metabolism
#19
D Lambert, P-Y Marie, P Lacolley, A Benetos, L Joly
OBJECTIVE: Aging led to the development of a proinflammatory phenotype and organ dysfunction. In situations of metabolic syndrome, it is associated with an increase in arterial stiffness and blood pressure.The main objective of this project is to establish a link between inflammation and arterial aging in a situation of metabolic syndrome in arterial and heart levels. DESIGN AND METHOD: The animal model chosen was a murine model developing metabolic syndrome. Mice received during a year, a high fat diet or a control diet...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27454597/unilateral-suppression-of-brown-fat-on-fdg-pet-ct-in-horner-syndrome
#20
Gary A Ulaner, Robert Samstein, Oren Cahlon, Wolfgang A Weber, Andreas Rimner
A 29-year-old woman underwent resection of a left anterior mediastinal thymoma and pleurectomy. Postsurgical FDG PET/CT scan demonstrated FDG avidity in the right neck and upper thoracic fat but relatively absent FDG-avid fat in the left neck and upper thorax. Bilateral FDG-avid fat was also apparent in the lower chest and upper abdomen. After surgery, the patient demonstrated Horner syndrome, with left-sided ptosis, miosis, and facial anhidrosis. It is hypothesized that left-sided sympathetic nerves were compromised during surgery, leading to Horner syndrome and denervation of ipsilateral brown fat...
October 2016: Clinical Nuclear Medicine
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