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https://www.readbyqxmd.com/read/29793082/atmospheric-impacts-of-a-natural-gas-development-within-the-urban-context-of-morgantown-west-virginia
#1
Philip J Williams, Matthew Reeder, Natalie J Pekney, David Risk, John Osborne, Michael McCawley
The Marcellus Shale Energy and Environment Laboratory (MSEEL) in West Virginia provides a unique opportunity in the field of unconventional energy research. By studying near-surface atmospheric chemistry over several phases of a hydraulic fracturing event, the project will help evaluate the impact of current practices, as well as new techniques and mitigation technologies. A total of 10 mobile surveys covering a distance of approximately 1500 km were conducted through Morgantown. Our surveying technique involved using a vehicle-mounted Los Gatos Research gas analyzer to provide geo-located measurements of methane (CH4 ) and carbon dioxide (CO2 )...
May 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29792944/enrichment-of-low-density-symbiont-dna-from-minute-insects
#2
Corinne M Stouthamer, Suzanne Kelly, Martha S Hunter
Symbioses between bacteria and insects are often associated with changes in important biological traits that can significantly affect host fitness. To a large extent, studies of these interactions have been based on physiological changes or induced phenotypes in the host, and the genetic mechanisms by which symbionts interact with their hosts have only recently become better understood. Learning about symbionts has been challenging in part due to difficulties such as obtaining enough high quality genomic material for high throughput sequencing technology, especially for symbionts present in low titers, and in small or difficult to rear non-model hosts...
May 21, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29792917/storage-visualization-and-navigation-of-3d-genomics-data
#3
Jérôme Waldispühl, Eric Zhang, Alexander Butyaev, Elena Nazarova, Yan Cyr
The field of 3D genomics grew at increasing rates in the last decade. The volume and complexity of 2D and 3D data produced is progressively outpacing the capacities of the technology previously used for distributing genome sequences. The emergence of new technologies provides also novel opportunities for the development of innovative approaches. In this paper, we review the state-of-the-art computing technology, as well as the solutions adopted by the platforms currently available.
May 21, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29792812/ultralow-damping-in-nanometer-thick-epitaxial-spinel-ferrite-thin-films
#4
Satoru Emori, Di Yi, Sam Crossley, Jacob J Wisser, Purnima P Balakrishnan, Behrouz Khodadadi, Padraic Shafer, Christoph Klewe, Alpha T N'Diaye, Brittany T Urwin, Krishnamurthy Mahalingam, Brandon Howe, Harold Y Hwang, Elke Arenholz, Yuri Suzuki
Pure spin currents, unaccompanied by dissipative charge flow, are essential for realizing energy-efficient nanomagnetic information and communications devices. Thin-film magnetic insulators have been identified as promising materials for spin-current technology, since they are thought to exhibit lower damping compared to their metallic counterparts. However, insulating behavior is not a sufficient requirement for low damping, as evidenced by the very limited options for low-damping insulators. Here, we demonstrate a new class of nanometer-thick ultralow-damping insulating thin films, based on design criteria that minimize orbital angular momentum and structural disorder...
May 24, 2018: Nano Letters
https://www.readbyqxmd.com/read/29792801/developing-a-novel-sulfoxide-containing-ms-cleavable-homobifunctional-cysteine-reactive-cross-linker-for-studying-protein-protein-interactions
#5
Craig B Gutierrez, Sarah A Block, Clinton Yu, Stephanie M Soohoo, Alexander S Huszagh, Scott D Rychnovsky, Lan Huang
Cross-linking mass spectrometry (XL-MS) has become an emerging technology for defining protein-protein interactions (PPIs) and elucidating architectures of large protein complexes. Up to now, the mostly widely used cross-linking reagents are targeting lysines. While such reagents have been successfully applied to map PPIs at the proteome-wide scale, comprehensive PPI profiling would require additional cross-linking chemistries. Cysteine is one of the most reactive amino acids and an attractive target for cross-linking owing to its unique role in protein structures...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792739/x-ray-phase-contrast-technology-in-breast-imaging-principles-options-and-clinical-application
#6
Seyedamir Tavakoli Taba, Timur E Gureyev, Maram Alakhras, Sarah Lewis, Darren Lockie, Patrick C Brennan
OBJECTIVE: The purpose of this article is to review different x-ray phase-contrast breast imaging techniques and their potential application in clinical settings. CONCLUSION: Phase-contrast imaging depicts not only the absorption contrast but also the refraction contrast of the transmitted x-ray beam. Early data suggest that this new modality may overcome some of the diagnostic limitations associated with current clinically available mammography systems and that it has potential for improving breast cancer detection...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792466/the-science-of-team-science-a-review-of-the-empirical-evidence-and-research-gaps-on-collaboration-in-science
#7
Kara L Hall, Amanda L Vogel, Grace C Huang, Katrina J Serrano, Elise L Rice, Sophia P Tsakraklides, Stephen M Fiore
Collaborations among researchers and across disciplinary, organizational, and cultural boundaries are vital to address increasingly complex challenges and opportunities in science and society. In addition, unprecedented technological advances create new opportunities to capitalize on a broader range of expertise and information in scientific collaborations. Yet rapid increases in the demand for scientific collaborations have outpaced changes in the factors needed to support teams in science, such as institutional structures and policies, scientific culture, and funding opportunities...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792380/alirocumab-as-add-on-therapy-to-statins-current-evidence-and-clinical-potential
#8
Johann Auer, Robert Berent
Atherosclerotic cardiovascular diseases (ASCVDs) are associated with a substantial mortality, physical morbidity, and mental disability. Elevated plasma low-density lipoprotein cholesterol (LDL-C) levels play a major role in the pathophysiology of ASCVDs. Statins have been shown to reduce ASCVD risk and associated events and are recommended as first-line therapy for treatment of hypercholesterolemia by current international guidelines. The key issue is to attain guideline-recommended LDL-C levels (below 70 mg/dl) for patients at very high cardiovascular risk...
May 1, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29792137/recent-trends-in-nanocrystals-for-pharmaceutical-applications
#9
Leming Sun, Yanzi Hu, Lianbing Zhang
BACKGROUND: As the quick development of modern methods and technologies currently, more and more drugs have been invented with a better efficiency. However, the poor water solubility has limited the drugs' pharmaceutical application. METHODS: Tremendous research has been put in the design and development of nanocrystals for pharmaceutical applications over the past few decades. The nanocrystals not only have the chance to solve the poor solubility problem, but also could conquer the bioavailability and even the specific delivery problems...
May 23, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29792066/capabilities-of-next-generation-patch-pump-improved-precision-instant-occlusion-detection-and-dual-hormone-therapy
#10
Forrest W Payne, Bradley Ledden, Greg Lamps
Insulin pumps allow patients to attain better blood glucose control with more lifestyle flexibility. Their size and cost, however, limit their usefulness. Current CSII pumps are bulky, intrusive, and expensive. SFC Fluidics is addressing these problems by developing a new type of wearable patch pump based on the patented electro-chemiosmotic (ECO) microfluidic pumping technology. This nonmechanical pumping technology allows accurate and precise delivery of very small amounts of insulin and/or other drugs, including concentrated insulin...
May 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29791883/relationship-between-modification-of-activated-sludge-wastewater-treatment-and-changes-in-antibiotic-resistance-of-bacteria
#11
Ewa Korzeniewska, Monika Harnisz
Biological treatment processes at wastewater treatment plants (WWTPs), which are the most common methods of sewage treatment, could cause selective elimination and/or changes in the proportions of phenotypes/genotypes within bacterial populations in effluent. Therefore, WWTPs based on activated sludge used in sewage treatment constitute an important reservoir of enteric bacteria which harbour potentially transferable resistance genes. Together with treated wastewater, these microorganisms can penetrate the soil, surface water, rural groundwater supplies and drinking water...
May 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29791795/surface-acoustic-wave-saw-driven-device-for-dynamic-cell-cultures
#12
Gina Greco, Matteo Agostini, Ilaria Tonazzini, Damiano Sallemi, Stefano Barone, Marco Cecchini
In the last decades new types of cell cultures have been introduced to provide better cell survival and development, and micro/nano-environmental physico-chemical conditions aimed to mimic those present in vivo. However, despite the efforts made, the systems available to date are often difficult to replicate and use. Here, an easy-to-use surface acoustic wave (SAW)-based platform is presented for realizing dynamic cell cultures that is compatible with standard optical microscopes, incubators and cell culture dishes...
May 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29791713/the-transradial-approach-for-lower-extremity-vascular-intervention
#13
Rami O Tadros, Vivek S Prakash, Melissa J Baldwin, Adam Korayem, Michael L Marin, Peter L Faries
Simultaneous technological advancements in both imaging as well as devices have resulted in an expansion of endovascular options for vascular access. In particular, radial access has traditionally been more favored for coronary interventions; its use in the aortoiliac and lower extremity vasculature has been constrained by the length of devices and the size of sheaths required. However, with increasing catheter shaft lengths, in addition to new thin-walled sheaths allowing for downsizing, the ability to perform transradial interventions on infrainguinal and infrageniculate vessels has been more readily facilitated...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791449/impact-of-involvement-of-non-formal-health-providers-on-tb-case-notification-among-migrant-slum-dwelling-populations-in-odisha-india
#14
Ambarish Dutta, Sarthak Pattanaik, Rajendra Choudhury, Pritish Nanda, Suvanand Sahu, Rajendra Panigrahi, Bijaya K Padhi, Krushna Chandra Sahoo, P R Mishra, Pinaki Panigrahi, Daisy Lekharu, Robert H Stevens
BACKGROUND: Migrant labourers living in the slums of urban and industrial patches across India make up a key sub-population so far controlling Tuberculosis (TB) in the country is concerned. This is because many TB patients from these communities- remain under reached by the Revised National Tuberculosis Control Programme (RNTCP) of India. This marginalized community usually seeks early-stage healthcare from "friendly neighbourhood" non-formal health providers (NFHPs). Because, RNTCP has limited capacity to involve the NFHPs, an implementation research project was conceived, whereby an external partner would engage with the NFHPs to enable them to identify early TB symptomatics from this key sub-population who would be then tested using Xpert MTB/RIF technology...
2018: PloS One
https://www.readbyqxmd.com/read/29791384/copying-of-holograms-by-spot-scanning-approach
#15
Makoto Okui, Koki Wakunami, Ryutaro Oi, Yasuyuki Ichihashi, Boaz Jessie Jackin, Kenji Yamamoto
To replicate holograms, contact copying has conventionally been used. In this approach, a photosensitive material is fixed together with a master hologram and illuminated with a coherent beam. This method is simple and enables high-quality copies; however, it requires a large optical setup for large-area holograms. In this paper, we present a new method of replicating holograms that uses a relatively compact optical system even for the replication of large holograms. A small laser spot that irradiates only part of the hologram is used to reproduce the hologram by scanning the spot over the whole area of the hologram...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791318/the-inhibitors-a-challenge-for-the-management-of-patients-with-hereditary-haemophilia-a
#16
Romeo-Gabriel Mihăilă
INTRODUCTION: Our research strategy was aimed at evaluating the possible implication of the type of factor VIII product administered as substitution treatment to haemophilia A patients in the occurrence of inhibitors and their consequences on the management. METHODS: Scientific articles from July 2015 to July 2017 were searched using the PubMed and PubMed Central databases. The used search terms included "haemophilia A", "inhibitors", "plasma-derived factor VIII" and "recombinant factor VIII"...
May 1, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29791219/approaches-to-leadership-and-managing-change-in-the-nhs
#17
Melanie Lumbers
The NHS is continually changing as research evidence leads to new practices and technology transforms the workplace. Resistance to some changes may occur because of staff fears about adapting to and coping with new methods. This is where change models and leadership are important. This article discusses changes taking place in the NHS, and some theoretical models of change. Leadership styles are also discussed, including those most useful for the nurse to use when leading a team and implementing change.
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29790941/asaim-a-galaxy-based-framework-to-analyze-microbiota-data
#18
Bérénice Batut, Kévin Gravouil, Clémence Defois, Saskia Hiltemann, Jean-François Brugère, Eric Peyretaillade, Pierre Peyret
Background: New generations of sequencing platforms coupled to numerous bioinformatics tools has led to rapid technological progress in metagenomics and metatranscriptomics to investigate complex microorganism communities. Nevertheless, a combination of different bioinformatic tools remains necessary to draw conclusions out of microbiota studies. Modular and user-friendly tools would greatly improve such studies. Findings: We therefore developed ASaiM, an Open-Source Galaxy-based framework dedicated to microbiota data analyses...
May 22, 2018: GigaScience
https://www.readbyqxmd.com/read/29790875/visible-light-induced-electropolymerization-of-suspended-hydrogel-bioscaffolds-in-a-microfluidic-chip
#19
Pan Li, Haibo Yu, Na Liu, Feifei Wang, Gwo-Bin Lee, Yuechao Wang, Lianqing Liu, Wen Jung Li
The development of microengineered hydrogels co-cultured with cells in vitro could advance in vivo bio-systems in both structural complexity and functional hierarchy, which holds great promise for applications in regenerative tissues or organs, drug discovery and screening, and bio-sensors or bio-actuators. Traditional hydrogel microfabrication technologies such as ultraviolet (UV) laser or multiphoton laser stereolithography and three-dimensional (3D) printing systems have advanced the development of 3D hydrogel micro-structures but need either expensive and complex equipment, or harsh material selection with limited photoinitiators...
May 23, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29790810/a-review-of-novel-technologies-and-techniques-associated-with-identification-of-bloodstream-infection-aetiologies-and-rapid-antimicrobial-genotypic-and-quantitative-phenotypic-determination
#20
Stephen Poole, Stephen P Kidd, Kordo Saeed
Introduction The antimicrobial aspect of management of patients with blood stream infections (BSI) and sepsis is time critical. In an era of increasing antimicrobial resistance, rapid detection and identification of bacteria with antimicrobial susceptibility is crucial to direct therapy early in the course of illness. Molecular techniques offer a potential solution to this. Areas covered In the present review the authors have discussed a number of novel solutions utilising a variety of molecular techniques for pathogen detection, identification and antimicrobial susceptibility...
May 23, 2018: Expert Review of Molecular Diagnostics
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