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https://www.readbyqxmd.com/read/29040540/new-debate-is-it-time-for-infertility-weight-loss-programmes-to-be-couple-based
#1
Damian Best, Alison Avenell, Siladitya Bhattacharya, Gertraud Stadler
With obesity on the rise in the general population, it has also become more prevalent among people of reproductive age. Weight loss has shown benefits in overweight women and men experiencing fertility problems. However, the existing weight-loss interventions for individuals with infertility are associated with high drop-out rates and limited success. In this article, we argue for the development of weight-loss programmes targeting couples, as couples are routinely seen in fertility clinics, rather than individuals...
October 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040325/trim5%C3%AE-spry-coiled-coil-interactions-optimize-avid-retroviral-capsid-recognition
#2
Marcin D Roganowicz, Sevnur Komurlu, Santanu Mukherjee, Jacek Plewka, Steven L Alam, Katarzyna A Skorupka, Yueping Wan, Damian Dawidowski, David S Cafiso, Barbie K Ganser-Pornillos, Edward M Campbell, Owen Pornillos
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and provides an effective species-specific barrier to retroviral infection. The TRIM5α SPRY domain directly binds the capsid with only very weak, millimolar-level affinity, and productive capsid recognition therefore requires both TRIM5α dimerization and assembly of the dimers into a multivalent hexagonal lattice to promote avid binding...
October 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29036930/automatic-hotspot-and-sun-glint-detection-in-uav-multispectral-images
#3
Damian Ortega-Terol, David Hernandez-Lopez, Rocio Ballesteros, Diego Gonzalez-Aguilera
Last advances in sensors, photogrammetry and computer vision have led to high-automation levels of 3D reconstruction processes for generating dense models and multispectral orthoimages from Unmanned Aerial Vehicle (UAV) images. However, these cartographic products are sometimes blurred and degraded due to sun reflection effects which reduce the image contrast and colour fidelity in photogrammetry and the quality of radiometric values in remote sensing applications. This paper proposes an automatic approach for detecting sun reflections problems (hotspot and sun glint) in multispectral images acquired with an Unmanned Aerial Vehicle (UAV), based on a photogrammetric strategy included in a flight planning and control software developed by the authors...
October 15, 2017: Sensors
https://www.readbyqxmd.com/read/29036647/investigation-of-secondary-mixed-radiation-field-around-a-medical-linear-accelerator
#4
Piotr Tulik, Monika Tulik, Maciej Maciak, Natalia Golnik, Damian Kabat, Tomasz Byrski, Jan Lesiak
The aim of this study is to investigate secondary mixed radiation field around linac, as the first part of an overall assessment of out-of-field contribution of neutron dose for new advanced radiation dose delivery techniques. All measurements were performed around Varian Clinic 2300 C/D accelerator at Maria Sklodowska-Curie Memorial, Cancer Center and Institute of Oncology, Krakow Branch. Recombination chambers REM-2 and GW2 were used for recombination index of radiation quality Q4 determination (as an estimate of quality factor Q), measurement of total tissue dose Dt and calculation of gamma and neutron components to Dt...
September 29, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036378/the-effect-of-costs-on-kenyan-households-demand-for-medical-care-why-time-and-distance-matter
#5
Matt Kukla, Niccie McKay, Richard Rheingans, Jeff Harman, Jessica Schumacher, Karen L Kotloff, Myrone M Levine, Robert Breiman, Tamer Farag, Damian Walker, Dilruba Nasrin, Richard Omore, Ciara O'Reilly, Eric Mintz
In an environment of constrained resources, policymakers must identify solutions for financing and delivering health services that are efficient and sustainable. However, such solutions require that policymakers understand the complex interaction between household utilization patterns, factors influencing household medical decisions, and provider performance. This study examined whether and under what conditions out-of-pocket, transportation, and time costs influenced Kenyan households' choice of medical provider for childhood diarrhoeal illnesses...
October 5, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29035989/-it-doesn-t-make-sense-for-us-not-to-have-one-understanding-reasons-why-community-sports-organizations-chose-to-participate-in-a-funded-automated-external-defibrillator-program
#6
Lauren V Fortington, Sheree Bekker, Damian Morgan, Caroline F Finch
OBJECTIVE: Implementation of automated external defibrillators (AEDs) in community sports settings is an important component of emergency medical planning. This study aimed to understand motivations for why sports organizations participated in a government-funded program that provided AEDs and associated first-aid training. DESIGN: Face-to-face interviews. SETTING: Community sports organizations in Victoria, Australia. PARTICIPANTS: Representatives from 14 organizations who participated in a government-funded AED program...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29031473/exploring-the-applicability-of-the-contextual-interference-effect-in-sports-practice
#7
Damian Farrow, Tim Buszard
This review will consider three key issues considered critical when determining the efficacy of the contextual interference effect when applied to sports practice. First, the issue of complexity is considered in relation to the amount of interference actually needed in the applied sports setting to create effective learning. Second, the traditional underpinning mechanism/s of contextual interference are discussed in relation to recent neurophysiological perspectives on their viability. A counter-position to these dominant theories is also presented drawing on an implicit learning framework...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29030045/the-potential-role-of-thermography-in-determining-the-efficacy-of-stroke-rehabilitation
#8
Béla Hegedűs
INTRODUCTION: Maintaining good physiological circulation in the extremities requires an optimally functioning muscle pump. Stroke symptoms indicate a change in venous circulation. In this study, changes were measured in joint function and microcirculation, and the correlation between them was examined. SETTING: Physiotherapy Center, Ss. Cosmas and Damian Rehabilitation Institute, Visegrád, Hungary. METHODOLOGY: Sixteen randomly selected poststroke patients with hemiparesis affecting mainly the upper extremities began undergoing rehabilitation 13 ± 4 days following stroke...
October 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29028923/detecting-presence-of-mutational-signatures-in-cancer-with-confidence
#9
Xiaoqing Huang, Damian Wojtowicz, Teresa M Przytycka
Motivation: Cancers arise as the result of somatically acquired changes in the DNA of cancer cells. However, in addition to the mutations that confer a growth advantage, cancer genomes accumulate a large number of somatic mutations resulting from normal DNA damage and repair processes as well as carcinogenic exposures or cancer related aberrations of DNA maintenance machinery. These mutagenic processes often produce characteristic mutational patterns called mutational signatures. The decomposition of a cancer genome's mutation catalog into mutations consistent with such signatures can provide valuable information about cancer etiology...
September 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027792/multifunctional-cytochrome-c-learning-new-tricks-from-an-old-dog
#10
Damián Alvarez-Paggi, Luciana Hannibal, María A Castro, Santiago Oviedo-Rouco, Veronica Demicheli, Veronica Tórtora, Florencia Tomasina, Rafael Radi, Daniel H Murgida
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible structure, particularly in the ferric form, such that it is able to sample a broad conformational space. Depending on the specific conditions, interactions, and cellular localization, different conformations may be stabilized, which differ in structure, redox properties, binding affinities, and enzymatic activity. The primary function is electron shuttling in oxidative phosphorylation, and is exerted by the so-called native cyt c in the intermembrane mitochondrial space of healthy cells...
October 13, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/29026089/a-large-scale-hearing-loss-screen-reveals-an-extensive-unexplored-genetic-landscape-for-auditory-dysfunction
#11
Michael R Bowl, Michelle M Simon, Neil J Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R Bower, Dave A Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, Glauco P Tocchini-Valentini, Xiang Gao, Allan Bradley, William C Skarnes, Mark Moore, Arthur L Beaudet, Monica J Justice, John Seavitt, Mary E Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M J Nutter, Ann M Flenniken, Colin McKerlie, Stephen A Murray, Karen L Svenson, Robert E Braun, David B West, K C Kent Lloyd, David J Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F Meehan, Helen E Parkinson, Lydia M Teboul, Sara Wells, Karen P Steel, Ann-Marie Mallon, Steve D M Brown
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29025985/safety-biodistribution-and-radiation-dosimetry-of-68-ga-ops202-68-ga-nodaga-jr11-in-patients-with-gastroenteropancreatic-neuroendocrine-tumors-a-prospective-phase-i-imaging-study
#12
Guillaume P Nicolas, Seval Beykan, Hakim Bouterfa, Jens Kaufmann, Andreas Bauman, Michael Lassmann, Jean Claude Reubi, Jean E F Rivier, Helmut R Maecke, Melpomeni Fani, Damian Wild
Preclinical and preliminary clinical evidence indicates that radiolabeled somatostatin receptor (sst) antagonists perform better than agonists in terms of detecting neuroendocrine tumors (NETs). This prospective phase I/II study is the first to evaluate an sst antagonist, (68)Ga-OPS202 ((68)Ga-NODAGA-JR11; NODAGA=1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid and JR11=Cpa-c(DCys-Aph(Hor)-DAph(Cbm)-Lys-Thr-Cys)-DTyr-NH2)) for PET imaging. Here, we report results of the phase I component of the study...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025855/management-of-children-and-young-people-with-an-acute-decrease-in-conscious-level-rcpch-guideline-update-2015
#13
REVIEW
Dilshad Marikar, Sarah Reynolds, Damian Roland
No abstract text is available yet for this article.
October 12, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29025454/an-audit-of-traumatic-brain-injury-tbi-in-a-busy-developing-world-trauma-service-exposes-a-significant-deficit-in-resources-available-to-manage-severe-tbi
#14
Ellen Jerome, Grant L Laing, John L Bruce, Ben Sartorius, Petra Brysiewicz, Damian L Clarke
BACKGROUND: Traumatic brain injury (TBI) affects large numbers of patients, both adults and children, and significant resources are needed to manage it. OBJECTIVE: To determine the burden of TBI and the adequacy of available resources to manage in the Pietermaritzburg Metropolitan Trauma Service (PMTS). METHODS: All patients with a TBI were identified from the hybrid electronic medical registry at Grey's and Edendale hospitals in Pietermaritzburg (PMB), KwaZulu-Natal, South Africa...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29023534/bewith-a-between-within-method-to-discover-relationships-between-cancer-modules-via-integrated-analysis-of-mutual-exclusivity-co-occurrence-and-functional-interactions
#15
Phuong Dao, Yoo-Ah Kim, Damian Wojtowicz, Sanna Madan, Roded Sharan, Teresa M Przytycka
The analysis of the mutational landscape of cancer, including mutual exclusivity and co-occurrence of mutations, has been instrumental in studying the disease. We hypothesized that exploring the interplay between co-occurrence, mutual exclusivity, and functional interactions between genes will further improve our understanding of the disease and help to uncover new relations between cancer driving genes and pathways. To this end, we designed a general framework, BeWith, for identifying modules with different combinations of mutation and interaction patterns...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29022221/eating-disorder-symptoms-and-the-2%C3%A2-%C3%A3-%C3%A2-2-model-of-perfectionism-mixed-perfectionism-is-the-most-maladaptive-combination
#16
Rita Maria Esposito, Joachim Stoeber, Lavinia E Damian, Guido Alessandri, Caterina Lombardo
PURPOSE: The 2 × 2 model of perfectionism (Gaudreau and Thompson in Personal Individ Diff 48:532-537, 2010) represents an important addition to the perfectionism literature, but so far has not been studied in relation with disordered eating. METHOD: Using the 2 × 2 model as analytic framework, this study examined responses from a convenience sample of 716 participants aged 19-68 years (71% female) investigating how self-oriented perfectionism (SOP) and socially prescribed perfectionism (SPP) predicted individual differences in eating disorder symptoms, additionally controlling for body mass index, gender, and age...
October 11, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29021953/bilateral-lung-disease-extensive-and-diffuse-diagnosis-of-pulmonary-alveolar-proteinosis-by-bronchoscopic-cryobiopsy
#17
Sebastián Gando, Roberto Duré, Damián Violi, Bibiana Vazquez, Gonzalo Labarca, Sebastián Fernandez-Bussy
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the intra-alveolar accumulation of a proteinaceous phospholipid-laden material called surfactant. Clinically, this disease should be suspected with respiratory failure in association with a crazy paving pattern on high-resolution chest computed tomography. We report a 24-year-old gentleman who was referred to us for a history of respiratory failure, treatment with invasive ventilation and tracheostomy. His blood exams and biochemistry were normal...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29020769/cofacially-arrayed-polyfluorenes-spontaneous-formation-of-%C3%AF-stacked-assemblies-in-the-gas-phase
#18
Maxim V Ivanov, Neil James Reilly, Brandon Uhler, Damian Kokkin, Rajendra Rathore, Scott Allen Reid
Understanding geometrical and size dependencies of through-space charge delocalization in multichromophoric systems is critical to model electron transfer and transport in materials and biomolecules. In this work, we examine the size evolution of hole delocalization in van der Waals clusters of fluorene (i.e., (F)n), where a range of geometries are possible, reflecting both -stacking and C-H/ interactions. Using mass-selected two-color resonant two-photon ionization spectroscopy (2CR2PI), we measure electronic spectra and vertical ionization potentials (IPs) in the gas-phase...
October 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29018540/efficacy-of-individualised-diets-in-patients-with-irritable-bowel-syndrome-a-randomised-controlled-trial
#19
Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal
BACKGROUND: Patients with irritable bowel syndrome (IBS) are often placed on diets guided by food intolerance assays, although these have not been validated. We assessed the effects of individualised diets in patients with IBS guided by a leucocyte activation test. METHODS: This is a parallel-group, double-blind, randomised controlled trial of 58 adults with IBS seen at an academic health centre in Northeast USA. Peripheral venous blood was analysed using a leucocyte activation test; individual foods were reported to produce positive or negative results...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29016808/molecular-differences-in-idh-wildtype-glioblastoma-according-to-mgmt-promoter-methylation
#20
Tobias Kessler, Felix Sahm, Ahmed Sadik, Damian Stichel, Anne Hertenstein, Guido Reifenberger, Angela Zacher, Michael Sabel, Ghazaleh Tabatabai, Joachim Steinbach, Ulrich Sure, Dietmar Krex, Anca-L Grosu, Melanie Bewerunge-Hudler, David Jones, Stefan M Pfister, Michael Weller, Christiane Opitz, Martin Bendszus, Andreas von Deimling, Michael Platten, Wolfgang Wick
Background: O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma. We investigated whether this marker furthermore defines a molecularly distinct tumor subtype with clinically different outcome. Methods: We analyzed copy number alteration (CNV) and methylation profiles of 1095 primary and 92 progressive Isocitrate dehydrogenase (IDH) wildtype glioblastomas, including paired samples from 49 patients. DNA mutation data from 182 glioblastoma samples of The Cancer Genome Atlas (TCGA) and RNA expression from 107 TCGA and 55 Chinese Glioma Genome Atlas samples were analyzed...
August 24, 2017: Neuro-oncology
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