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https://www.readbyqxmd.com/read/28432322/histological-chemical-and-behavioural-evidence-of-pedal-communication-in-brown-bears
#1
Agnieszka Sergiel, Javier Naves, Piotr Kujawski, Robert Maślak, Ewa Serwa, Damián Ramos, Alberto Fernández-Gil, Eloy Revilla, Tomasz Zwijacz-Kozica, Filip Zięba, Johanna Painer, Nuria Selva
Most mammals rely upon scent for intraspecific communication. As most bear species have large home ranges and are non-territorial, scent deposit while walking could be an effective way to communicate with conspecifics. Here, we investigate the existence of pedal glands in brown bears and their role in chemical communication from a histological, biochemical and behavioural perspective. We found eccrine glands in footpads, and prominent apocrine and sebaceous glands in the interdigital, metacarpal and metatarsal skin sections...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28430701/tear-function-and-ocular-surface-alterations-after-accelerated-corneal-collagen-crosslinking-in-progressive-keratoconus
#2
Zisis Gatzioufas, Mohamed Elalfy, Samer Hamada, Damian Lake
No abstract text is available yet for this article.
May 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28428736/simple-sugar-supplementation-abrogates-exercise-induced-increase-in-hepcidin-in-young-men
#3
Maja Tomczyk, Jakub Kortas, Damian Flis, Wojciech Skrobot, Rafal Camilleri, Jedrzej Antosiewicz
BACKGROUND: At present many young people experience too much body iron accumulation. The reason of this phenomenon is not clear. There is accumulating evidences that not proper diet and lack of exercise could be a main contributing factors. This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism. METHODS: A group of physically active young men completed an incremental exercise test before and after a 3-day diet supplemented with fructose (4 g/kg BM) or glucose (4 g/kg BM)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28428330/genomic-responses-to-socio-sexual-environment-in-male-drosophila-melanogaster-exposed-to-conspecific-rivals
#4
Irina I Mohorianu, Amanda Bretman, Damian T Smith, Emily Fowler, Tamas Dalmay, Tracey Chapman
Socio-sexual environments have profound effects on fitness. Local sex ratios can alter the threat of sexual competition, to which males respond via plasticity in reproductive behaviours and ejaculate composition. In Drosophila melanogaster, males detect the presence of conspecific mating rivals prior to mating using multiple, redundant sensory cues. Males that respond to rivals gain significant fitness benefits by altering mating duration and ejaculate composition. Here we investigated the underlying genome-wide changes involved...
April 20, 2017: RNA
https://www.readbyqxmd.com/read/28428282/whither-radioimmunotherapy-to-be-or-not-to-be
#5
Damian J Green, Oliver W Press
Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas. Two "first-generation," directly radiolabeled anti-CD20 antibodies, (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan, were FDA-approved more than a decade ago but have been little utilized because of a variety of medical, financial, and logistic obstacles. Newer technologies employing multistep "pretargeting" methods, particularly those utilizing bispecific antibodies, have greatly enhanced the therapeutic efficacy of radioimmunotherapy and diminished its toxicities...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28423759/developing-the-safety-case-for-medipi-an-open-source-platform-for-self-management
#6
Andrew Carr, Damian Murphy, Ian Dugdale, Anne Dyson, Ibrahim Habli, Richard Robinson
mHealth and Telehealth technologies are increasingly used to provide personalised, interactive and timely access to health data, thereby helping patients take a more active role in their care process. However, similar to any intervention, the use of these technologies has to be assured to justify that they do not compromise patient safety. In this paper, we discuss the development of a safety case for MediPi; a research prototype for a low-cost open-source digital platform that collects physiological data from patients, at home, and makes it available to decision-support systems used by clinicians...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28419550/urban-primate-ranging-patterns-gps-collar-deployments-for-macaca-fascicularis-and-m-sylvanus
#7
Amy R Klegarth, Hope Hollocher, Lisa Jones-Engel, Eric Shaw, Benjamin P Y-H Lee, Tessa Feeney, Damian Holmes, Dale Laguea, Agustín Fuentes
The global increase in urbanization is leading to heavier interface between humans and wildlife. Within these anthropogenic landscapes, little is known about ranging patterns, particularly with regard to urban primates. Here we present the results of the first long-term deployment of multiple GPS collars on two species of macaques to investigate the impacts of urbanization on urban primate ranging patterns in Singapore and Gibraltar. Collars data acquisition were excellent with respect to the amount, quality, and accuracy of data collected; however, remote connectivity and drop-off functionality was poor across all deployments...
May 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28419197/inhibition-of-sarcolemmal-fat-cd36-by-sulfo-n-succinimidyl-oleate-rapidly-corrects-metabolism-and-restores-function-in-the-diabetic-heart-following-hypoxia-reoxygenation
#8
Latt S Mansor, Maria da Luz Sousa Fialho, Georgina Yea, Will A Coumans, James A West, Matthew Kerr, Carolyn A Carr, Joost J F P Luiken, Jan F C Glatz, Rhys D Evans, Julian L Griffin, Damian J Tyler, Kieran Clarke, Lisa C Heather
Aims: The type 2 diabetic heart oxidizes more fat and less glucose, which can impair metabolic flexibility and function. Increased sarcolemmal fatty acid translocase (FAT/CD36) imports more fatty acid into the diabetic myocardium, feeding increased fatty acid oxidation and elevated lipid deposition. Unlike other metabolic modulators that target mitochondrial fatty acid oxidation, we proposed that pharmacologically inhibiting fatty acid uptake, as the primary step in the pathway, would provide an alternative mechanism to rebalance metabolism and prevent lipid accumulation following hypoxic stress...
April 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28419027/athletes-intending-to-use-sports-supplements-are-more-likely-to-respond-to-a-placebo
#9
Philip Hurst, Abby Foad, Damian Coleman, Chris Beedie
PURPOSE: We investigated associations between athletes' use of sport supplements and their responsiveness to placebo and nocebo interventions. METHODS: Participants (n=627) reported their intention to use, and actual use of, sport supplements. They then completed a 5x20m repeat sprint protocol in the baseline condition, prior to being randomized to one of three treatments. Participants in the positive-belief treatment were administered an inert capsule described as a potent supplement which would improve sprint performance...
April 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28415554/phytosynthesis-of-silver-nanoparticles-using-aqueous-leaf-extracts-of-lippia-citriodora-antimicrobial-larvicidal-and-photocatalytic-evaluations
#10
Elias E Elemike, Damian C Onwudiwe, Anthony C Ekennia, Richard C Ehiri, Nnaemeka J Nnaji
Nanoscience and nanotechnology represent new and enabling platforms that promise to provide broad range of novel and improved technologies for environmental, biological and other scientific applications. This study reports the synthesis of silver nanoparticles mediated by aqueous leaf extract of Lippia citriodora at two different temperatures of 50°C and 90°C. The synthesis of colloidal silver nanoparticles (AgNPs) was monitored by the use of UV-visible spectroscopy at different temperatures and time intervals...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413072/progressive-regression-of-intracranial-arteriovenous-malformations-after-onyx-embolization
#11
Damian Kocur, Nikodem Przybyłko, Mariusz Hofman, Tomasz Jamróz, Hanna Doleżych, Jan Baron, Stanisław Kwiek
Progressive regression of cerebral arteriovenous malformations (AVMs) is a rare phenomenon that may occur spontaneously or after previous surgical or endovascular incomplete obliteration. We present two cases of AVMs occluded partially with Onyx followed by the unexpected cure of the lesions with the angiographic evidences as well as multiannual follow-up.
April 4, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28410592/study-of-sv40-large-t-antigen-nucleotide-specificity-for-dna-unwinding
#12
Damian Wang, Ana Lucia Álvarez-Cabrera, Xiaojiang S Chen
BACKGROUND: Simian Virus 40 (SV40) Large Tumor Antigen (LT) is an essential enzyme that plays a vital role in viral DNA replication in mammalian cells. As a replicative helicase and initiator, LT assembles as a double-hexamer at the SV40 origin to initiate genomic replication. In this process, LT converts the chemical energy from ATP binding and hydrolysis into the mechanical work required for unwinding replication forks. It has been demonstrated that even though LT primarily utilizes ATP to unwind DNA, other NTPs can also support low DNA helicase activity...
April 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28409311/symmetry-does-not-come-for-free-cellular-mechanisms-to-achieve-a-symmetric-cell-division
#13
Damian Dudka, Patrick Meraldi
During mitosis cells can divide symmetrically to proliferate or asymmetrically to generate tissue diversity. While the mechanisms that ensure asymmetric cell division have been extensively studied, it is often assumed that a symmetric cell division is the default outcome of mitosis. Recent studies, however, imply that the symmetric nature of cell division is actively controlled, as they reveal numerous mechanisms that ensure the formation of equal-sized daughter cells as cells progress through cell division...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28409055/enhanced-surveillance-for-the-third-united-nations-conference-on-small-island-developing-states-apia-samoa-september-2014
#14
Paul White, Salanieta Saketa, Alexis Durand, Saine Vaai-Nielsen, Tile Ah Leong-Lui, Take Naseri, Ailuai Matalima, Filipina Amosa, Alize Mercier, Christelle Lepers, Vjesh Lal, Richard Wojcik, Sheri Lewis, Adam Roth, Yvan Souares, Onofre Edwin Merilles, Damian Hoy
The Ministry of Health in Samoa, in partnership with the Pacific Community, successfully implemented enhanced surveillance for the high-profile Third United Nations Conference on Small Island Developing States held concurrently with the popular local Teuila festival during a widespread chikungunya outbreak in September 2014. Samoa's weekly syndromic surveillance system was expanded to 12 syndromes and 10 sentinel sites from four syndromes and seven sentinel sites; sites included the national hospital, four private health clinics and three national health service clinics...
January 2017: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/28407863/reproductive-characteristics-of-female-white-tailed-deer-odocoileus-virginianus-in-the-midwestern-usa
#15
Michelle L Green, Amy C Kelly, Damian Satterthwaite-Phillips, Mary Beth Manjerovic, Paul Shelton, Jan Novakofski, Nohra Mateus-Pinilla
Knowledge of reproductive characteristics of wild populations is necessary to inform responsible management decisions that promote herd health. As management, goals, and free-ranging populations change over time and landscapes, updated knowledge of reproductive characteristics are needed to inform responsible management practices. We estimated reproductive characteristics of female white-tailed deer in Illinois, including pregnancy rate, litter size, fetal growth and fetal sex ratio. We found maternal age to have an important influence on several reproductive factors...
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28406952/individual-and-contextual-factors-associated-with-appropriate-healthcare-seeking-behavior-among-febrile-children-in-tanzania
#16
Juma Adinan, Damian J Damian, Neema R Mosha, Innocent B Mboya, Redempta Mamseri, Sia E Msuya
INTRODUCTION: Fever in malaria endemic areas, has been shown to strongly predict malaria infection and is a key symptom influencing malaria treatment. WHO recommended confirmation testing for Plasmodium spp. before initiation of antimalarials due to increased evidence of the decrease of morbidity and mortality from malaria, decreased malaria associated fever, and increased evidence of high prevalence of non-malaria fever. To immediately diagnose and promptly offer appropriate management, caretakers of children with fever should seek care where these services can be offered; in health facilities...
2017: PloS One
https://www.readbyqxmd.com/read/28405465/effect-of-the-needle-free-intra-dermal-application-of-liquids-vaccination-on-the-welfare-of-pregnant-sows
#17
Déborah Temple, Damián Escribano, Marta Jiménez, Eva Mainau, José J Cerón, Xavier Manteca
BACKGROUND: In commercial pig production, sows are often vaccinated several times per gestation period, resulting in reduced welfare. This preliminary experiment investigated whether the needle-free IDAL vaccinator improves welfare through reduction of stress markers, improvement of behavioural and health parameters compared to traditional needle-syringe method. RESULTS: Two treatments (IDAL and NEEDLE) in 6 replicate pens of gestating sows (15 sows per pen) were evaluated using Porcilis® PRRS...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/28405317/changes-in-gene-expression-of-neo-squamous-mucosa-after-endoscopic-treatment-for-dysplastic-barrett-s-esophagus-and-intramucosal-adenocarcinoma
#18
Angelique Levert-Mignon, Michael J Bourke, Sarah J Lord, Andrew C Taylor, Antony R Wettstein, Melanie Edwards, Natalia K Botelho, Rebecca Sonson, Chatura Jayasekera, Oliver M Fisher, Melissa L Thomas, Finlay Macrae, Damian J Hussey, David I Watson, Reginald V Lord
BACKGROUND: Endoscopic therapy, including by radiofrequency ablation (RFA) or endoscopic mucosal resection (EMR), is first line treatment for Barrett's esophagus (BE) with high-grade dysplasia (HGD) or intramucosal cancer (IMC) and may be appropriate for some patients with low-grade dysplasia (LGD). OBJECTIVE: The purpose of this study was to investigate the molecular effects of endotherapy. METHODS: mRNA expression of 16 genes significantly associated with different BE stages was measured in paired pre-treatment BE tissues and post-treatment neo-squamous biopsies from 36 patients treated by RFA (19 patients, 3 IMC, 4 HGD, 12 LGD) or EMR (17 patients, 4 IMC, 13 HGD)...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28404094/development-and-validation-of-a-dynamic-outcome-prediction-model-for-paracetamol-induced-acute-liver-failure-a-cohort-study
#19
William Bernal, Yanzhong Wang, James Maggs, Christopher Willars, Elizabeth Sizer, Georg Auzinger, Nicholas Murphy, Damian Harding, Ahmed Elsharkawy, Kenneth Simpson, Fin Stolze Larsen, Nigel Heaton, John O'Grady, Roger Williams, Julia Wendon
BACKGROUND: Early, accurate prediction of survival is central to management of patients with paracetamol-induced acute liver failure to identify those needing emergency liver transplantation. Current prognostic tools are confounded by recent improvements in outcome independent of emergency liver transplantation, and constrained by static binary outcome prediction. We aimed to develop a simple prognostic tool to reflect current outcomes and generate a dynamic updated estimation of risk of death...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28402559/occipital-nerve-stimulation-attenuates-neuronal-firing-response-to-mechanical-stimuli-in-the-ventral-posteromedial-thalamus-of-a-rodent-model-of-chronic-migraine
#20
Ian Walling, Heather Smith, Lucy E Gee, Brian Kaszuba, Arun Chockalingam, Andrei Barborica, Cristian Donos, Damian S Shin, Julie G Pilitsis
BACKGROUND: Chronic migraine (CM) is a highly debilitating disease, and many patients remain refractory to medicinal therapy. Given the convergent nature of neuronal networks in the ventral posteromedial nucleus (VPM) and the evidence of sensitization of pain circuitry in this disease, we hypothesize CM rats will have increased VPM neuronal firing, which can be attenuated using occipital nerve stimulation (ONS). OBJECTIVE: To determine whether VPM firing frequency differs between CM and sham rats, and whether ONS significantly alters firing rates during the application of mechanical stimuli...
April 10, 2017: Neurosurgery
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