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https://www.readbyqxmd.com/read/29652340/87-w-1018-nm-yb-fiber-ultrafast-seeding-source-for-cryogenic-yb-yttrium-lithium-fluoride-amplifier
#1
Yi Hua, Wei Liu, Michael Hemmer, Luis E Zapata, Gengji Zhou, Damian N Schimpf, Tino Eidam, Jens Limpert, Andreas Tünnermann, Franz X Kärtner, Guoqing Chang
We demonstrate a compact and robust Yb-fiber master-oscillator power-amplifier system operating at 1018 nm with 2.5-nm bandwidth and 1-ns stretched pulse duration. It produces 87-W average power and 4.9-μJ pulse energy, constituting a powerful seed source for cryogenically cooled ultrafast Yb: yttrium lithium fluoride (Yb:YLF) amplifiers.
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29650005/the-effect-of-case-management-and-vector-control-interventions-on-space-time-patterns-of-malaria-incidence-in-uganda
#2
Julius Ssempiira, John Kissa, Betty Nambuusi, Carol Kyozira, Damian Rutazaana, Eddie Mukooyo, Jimmy Opigo, Fredrick Makumbi, Simon Kasasa, Penelope Vounatsou
BACKGROUND: Electronic reporting of routine health facility data in Uganda began with the adoption of the District Health Information Software System version 2 (DHIS2) in 2011. This has improved health facility reporting and overall data quality. In this study, the effects of case management with artemisinin-based combination therapy (ACT) and vector control interventions on space-time patterns of disease incidence were determined using DHIS2 data reported during 2013-2016. METHODS: Bayesian spatio-temporal negative binomial models were fitted on district-aggregated monthly malaria cases, reported by two age groups, defined by a cut-off age of 5 years...
April 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29628523/impact-of-environmental-diversity-of-hunting-complexes-in-the-lublin-region-on-ontogenetic-quality-indicators-in-roe-deer-capreolus-capreolus
#3
Piotr Czyżowski, Leszek Drozd, Mirosław Karpiński, Katarzyna Tajchman, Małgorzata Goleman, Justyna Wojtaś, Damian Zieliński
Populations of game are not confined to single ecosystems but function within higher-order units, e.g. ecological landscape. The basis for the establishment of the hunting complexes was the assumption that the existing game hunting grounds, i.e. the basic units implementing game management, are too small and do not cover the natural areas inhabited by game populations. Roe deer are flexible species and easily adapt to various site conditions, so they inhabit many different habitats, from large forest complexes, through small in-field tree stands and shrubs, to treeless grounds and field monocultures...
2018: Biologia
https://www.readbyqxmd.com/read/29626206/high-throughput-mouse-phenomics-for-characterizing-mammalian-gene-function
#4
REVIEW
Steve D M Brown, Chris C Holmes, Ann-Marie Mallon, Terrence F Meehan, Damian Smedley, Sara Wells
We are entering a new era of mouse phenomics, driven by large-scale and economical generation of mouse mutants coupled with increasingly sophisticated and comprehensive phenotyping. These studies are generating large, multidimensional gene-phenotype data sets, which are shedding new light on the mammalian genome landscape and revealing many hitherto unknown features of mammalian gene function. Moreover, these phenome resources provide a wealth of disease models and can be integrated with human genomics data as a powerful approach for the interpretation of human genetic variation and its relationship to disease...
April 6, 2018: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/29626016/one-year-s-activity-and-outcome-data-from-an-ambulatory-cardiology-unit
#5
Jill Byrne, Damian McCall
In 2015, the Belfast Trust piloted an ambulatory cardiology unit (ACU). The ethos of the ACU was to reduce pressure on the Emergency Department by providing a unit where rapid evaluation, treatment and follow-up could be provided by the cardiology team and, at the same time, reduce inpatient admissions to cardiology beds. The service proved effective in reducing admissions to cardiology beds by 13.5% over a 1-year period, while patient outcomes at 30 days and 6 months demonstrated that the service is safe, with only 1...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29621334/how-cyclophosphamide-at-environmentally-relevant-concentration-influences-daphnia-magna-life-history-and-its-proteome
#6
Małgorzata Grzesiuk, Damian Mielecki, Tomasz Pilżys, Damian Garbicz, Michał Marcinkowski, Elżbieta Grzesiuk
The waste of commonly used medicines is known to contaminate freshwater ecosystems. Pharmaceuticals can be toxic, mutagenic, or modifying to freshwater organisms even at low concentrations if consider their permanent presence in the environment. Chemotherapeutics used to treat cancer, and in particular alkylating agents, contribute significantly to this form of pollution, the latter introducing cytotoxic and/or mutagenic lesions to the DNA and RNA of organisms which can be disruptive to their cells. The aim of the present study was to investigate the influence of the alkylating anticancer agent cyclophosphamide (CP) on Daphnia magna clones...
2018: PloS One
https://www.readbyqxmd.com/read/29620950/a-systematic-review-and-meta-analysis-reveals-altered-drug-pharmacokinetics-in-humans-during-acute-exposure-to-terrestrial-high-altitude-clinical-justification-for-dose-adjustment
#7
Damian Miles Bailey, Benjamin S Stacey, Mark Gumbleton
OBJECTIVE: While physiological responses during acute ascent to terrestrial high altitude (HA) have the potential to alter the pharmacokinetics (PKs) that define absorption and disposition of medicinal drugs, there have been no systematic reviews and meta-analyses performed to date. METHODS: We conducted a systematic literature search in June 2017 using NCBI PubMed, EMBASE, Web of Science, and Ovid MEDLINE databases to identify relevant observational studies. Studies were deemed eligible based on the following criteria: (1) participants: healthy, nonacclimatized male or female lowlanders (born and bred at sea level) and (2) environment: exposure to low altitude (LA, ≤600 m), followed by terrestrial high altitude (HA, ≤24 hours to ≥2500 m), the time course specifically selected to avoid interpretive complications associated with erythrocytosis...
April 5, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29619879/cisplatin-induced-oxidative-stress-stimulates-renal-fas-ligand-shedding
#8
Hitesh Soni, Damian Kaminski, Rajashekhar Gangaraju, Adebowale Adebiyi
Acute kidney injury (AKI), a significant complication of cisplatin chemotherapy is associated with reactive oxygen species (ROS)-dependent renal cell death, but the cellular targets of ROS in cisplatin nephrotoxicity are not fully resolved. Here, we investigated cisplatin-induced oxidative renal damage and tested the hypothesis that ROS-dependent shedding of death activator Fas ligand (FasL) occurs in cisplatin nephropathy. We show that intraperitoneal injection of sulfobutyl ether-β-cyclodextrin (Captisol™)-solubilized cisplatin elevated the level of lipid peroxidation product malondialdehyde in mouse kidneys and urinary concentration of oxidative DNA damage biomarker 8-hydroxy-2'-deoxyguanosine...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29619553/preoperative-pcr-analysis-of-synovial-fluid-has-limited-value-for-the-diagnosis-of-periprosthetic-joint-infections-of-total-knee-arthroplasties
#9
Bernd Fink, Markus Steurer, Sigrid Hofäcker, Peter Schäfer, Dieter Sandow, Philipp Schuster, Damian Oremek
Preoperative diagnosis of periprosthetic joint infection (PJI) is important because of the therapeutic consequences. This prospective study was designed to answer the question, if preoperative PCR analysis of the synovial fluid in addition to the culture and the CRP analysis of the blood are helpful for the diagnosis of PJI in knee arthroplasties. Before revision CRP analysis of the blood, cultivation and PCR analysis of synovial fluid of 116 knee endoprostheses were performed. During revision surgery, five tissue samples of the periprosthetic tissue were cultured and five further samples subjected to histological analysis...
April 4, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29619365/chemical-reactivity-and-spectroscopy-explored-from-qm-mm-molecular-dynamics-simulations-using-the-lio-code
#10
REVIEW
Juan P Marcolongo, Ari Zeida, Jonathan A Semelak, Nicolás O Foglia, Uriel N Morzan, Dario A Estrin, Mariano C González Lebrero, Damián A Scherlis
In this work we present the current advances in the development and the applications of LIO , a lab-made code designed for density functional theory calculations in graphical processing units (GPU), that can be coupled with different classical molecular dynamics engines. This code has been thoroughly optimized to perform efficient molecular dynamics simulations at the QM/MM DFT level, allowing for an exhaustive sampling of the configurational space. Selected examples are presented for the description of chemical reactivity in terms of free energy profiles, and also for the computation of optical properties, such as vibrational and electronic spectra in solvent and protein environments...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29619130/copeptin-as-a-prognostic-marker-in-acute-chest-pain-and-suspected-acute-coronary-syndrome
#11
Beata Morawiec, Damian Kawecki, Brygida Przywara-Chowaniec, Mariusz Opara, Piotr Muzyk, Lam Ho, Lui Chun Tat, Artur Gabrysiak, Olivier Muller, Ewa Nowalany-Kozielska
Background: In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG. Methods: Consecutive patients suspected for an ACS were enrolled prospectively. Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission...
2018: Disease Markers
https://www.readbyqxmd.com/read/29615697/fathers-eye-colour-sways-daughters-choice-of-both-long-and-short-term-partners
#12
Paola Bressan, Valeria Damian
In several species, mate choice is influenced by parental features through sexual imprinting, but in humans evidence is scarce and open to alternative explanations. We examined whether daughters' preference for mates with light vs dark eyes is affected by the eye colour of parents. In an online study, over one thousand women rated the attractiveness of men as potential partners for either a long- or a short-term relationship. Each male face was shown twice, with light (blue or green) and with dark (brown or dark brown) eyes...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611166/diagnostic-and-prognostic-value-of-qrs-duration-and-qtc-interval-in-patients-with-suspected-myocardial-infarction
#13
Janosch Cupa, Ivo Strebel, Patrick Badertscher, Roger Abächerli, Raphael Twerenbold, Lukas Schumacher, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Maechler, Nikola Kozhuharov, Maria Rubini Giménez, Karin Wildi, Jeanne du Fay de Lavallaz, Zaid Sabti, Lorraine Sazgary, Christian Puelacher, Deborah Mueller, Chiara Bianci, Òscar Miró, Carolina Fuenzalida, Sofia Calderón, Javier Martin-Sanchez, Sergio Lopez Iglesias, Beata Morawiec, Damian Kawecki, Jiri Parenica, Dagmar I Keller, Nicolas Geigy, Stefan Osswald, Christian Mueller, Tobias Reichlin
BACKGROUND: While prolongation of QRS duration and QTc interval during acute myocardial infarction (AMI) has been reported in animals, limited data is available for these readily available electrocardiography (ECG) markers in humans. METHODS: Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected AMI in a prospective diagnostic multicentre study were prospectively assessed. Digital 12-lead ECGs were recorded at presentation. QRS duration and QTc interval were automatically calculated in a blinded fashion...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29610263/cardiac-dysfunction-and-metabolic-inflexibility-in-a-mouse-model-of-diabetes-without-dyslipidaemia
#14
Maria Rohm, Dragana Savic, Vicky Ball, M Kate Curtis, Sarah Bonham, Roman Fischer, Nathalie Legrave, James I MacRae, Damian J Tyler, Frances M Ashcroft
Diabetes is a well-established risk factor for heart disease leading to impaired cardiac function and a metabolic switch towards fatty acid usage. Here, we investigated if hyperglycaemia/hypoinsulinaemia in the absence of dyslipidaemia is sufficient to drive these changes, and if they can be reversed by restoring euglycaemia. Using the βV59M mouse model, in which diabetes can be rapidly induced and reversed, we show that stroke volume and cardiac output were reduced within two weeks of diabetes induction. Flux through pyruvate dehydrogenase was decreased, as measured in vivo by hyperpolarized [1-13 C]pyruvate magnetic resonance spectroscopy...
April 2, 2018: Diabetes
https://www.readbyqxmd.com/read/29609523/the-contribution-of-fibrinogen-to-inflammation-and-neuronal-density-in-human-traumatic-brain-injury
#15
Damian Robert Jenkins, Matthew J Craner, Margaret M Esiri, Gabriele C DeLuca
Traumatic brain injury is a leading cause of death and disability, particularly among the young. Despite this, no disease-specific treatments exist. Recently, descriptions of BBB disruption and parenchymal fibrinogen deposition have been reported in acute traumatic brain injury and in long-term survival; however, their contribution to the neuropathology of TBI remains unknown. 1, 2 The presence of fibrinogen - a well-documented activator of microglia/macrophages - may be associated with neuroinflammation, and neuronal/axonal injury...
April 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29609175/involvement-of-ascorbate-peroxidase-and-heat-shock-proteins-on-citrus-tolerance-to-combined-conditions-of-drought-and-high-temperatures
#16
Damián Balfagón, Sara I Zandalinas, Pablo Baliño, María Muriach, Aurelio Gómez-Cadenas
Usually several environmental stresses occur in nature simultaneously causing a unique plant response. However, most of the studies until now have focused in individually-applied abiotic stress conditions. Carrizo citrange (Poncirus trifoliata L. Raf. X Citrus sinensis L. Osb.) and Cleopatra mandarin (Citrus reshni Hort. ex Tan.) are two citrus rootstocks with contrasting tolerance to drought and heat stress and have been used in this work as a model for the study of plant tolerance to the combination of drought and high temperatures...
March 27, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29608410/armillaria-mexicana-a-newly-described-species-from-mexico
#17
Rubén Damián Elías-Román, Rosario Medel-Ortiz, Dionicio Alvarado-Rosales, John W Hanna, Amy L Ross-Davis, Mee-Sook Kim, Ned B Klopfenstein
Armillaria mexicana (Agaricales, Physalacriaceae) is described as a new species based on morphology, DNA sequence data, and phylogenetic analyses. It clearly differs from previously reported Armillaria species in North, Central, and South America. It is characterized by the absence of fibulae in the basidioma, abundant cheilocystidia, and ellipsoidal, hyaline basidiospores that are apparently smooth under light microscope, but slightly to moderately rugulose under scanning electron microscope. It is differentiated from other Armillaria species by macromorphological characters, including annulus structure, pileus and stipe coloration, and other structures...
January 19, 2018: Mycologia
https://www.readbyqxmd.com/read/29607648/illuminating-the-energy-landscape-of-gpcrs-the-key-contribution-of-solution-state-nmr-associated-with-escherichia-coli-as-an-expression-host
#18
Marina Casiraghi, Marjorie Damian, Ewen Lescop, Jean-Louis Baneres, Laurent J Catoire
Conformational dynamics of GPCRs are central to their function but are difficult to explore at the atomic scale. Solution-state NMR has provided the major contribution in that area during the past decade, despite non-optimized labeling schemes due to the use of insect cells, and to a lesser extent yeast, as the main expression hosts. Indeed, the most efficient isotope-labeling scheme ever to address energy landscape issues for large proteins or protein complexes relies on the use of 13CH3 probes immersed in a perdeuterated dipolar environment, which is essentially out of reach of eukaryotic expression systems...
April 2, 2018: Biochemistry
https://www.readbyqxmd.com/read/29607013/fresh-is-best-accurate-snp-genotyping-from-koala-scats
#19
Anthony J Schultz, Romane H Cristescu, Bethan L Littleford-Colquhoun, Damian Jaccoud, Céline H Frère
Maintaining genetic diversity is a crucial component in conserving threatened species. For the iconic Australian koala, there is little genetic information on wild populations that is not either skewed by biased sampling methods (e.g., sampling effort skewed toward urban areas) or of limited usefulness due to low numbers of microsatellites used. The ability to genotype DNA extracted from koala scats using next-generation sequencing technology will not only help resolve location sample bias but also improve the accuracy and scope of genetic analyses (e...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29606416/mechanisms-underlying-decision-making-as-revealed-by-deep-brain-stimulation-in-patients-with-parkinson-s-disease
#20
Damian M Herz, Simon Little, David J Pedrosa, Gerd Tinkhauser, Binith Cheeran, Tom Foltynie, Rafal Bogacz, Peter Brown
To optimally balance opposing demands of speed and accuracy during decision-making, we must flexibly adapt how much evidence we require before making a choice. Such adjustments in decision thresholds have been linked to the subthalamic nucleus (STN), and therapeutic STN deep-brain stimulation (DBS) has been shown to interfere with this function. Here, we performed continuous as well as closed-loop DBS of the STN while Parkinson's disease patients performed a perceptual decision-making task. Closed-loop STN DBS allowed temporally patterned STN stimulation and simultaneous recordings of STN activity...
March 20, 2018: Current Biology: CB
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