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Mariano Garcia-Arranz, Damian Garcia-Olmo, Luz Vega-Clemente, Maurice Stroun, Peter B Gahan
In vitro studies of partially purified virtosomes from rat liver showed inhibition of cell multiplication in four normal and two tumour cell lines. In vivo, the liver virtosomes slowed tumour growth and limited metastases in rats bearing DHD/K12-PROb cell initiated tumours.
2016: Advances in Experimental Medicine and Biology
Maris S Arcilla, Jarne M van Hattem, Manon R Haverkate, Martin C J Bootsma, Perry J J van Genderen, Abraham Goorhuis, Martin P Grobusch, Astrid M Oude Lashof, Nicky Molhoek, Constance Schultsz, Ellen E Stobberingh, Henri A Verbrugh, Menno D de Jong, Damian C Melles, John Penders
BACKGROUND: International travel contributes to the dissemination of antimicrobial resistance. We investigated the acquisition of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) during international travel, with a focus on predictive factors for acquisition, duration of colonisation, and probability of onward transmission. METHODS: Within the prospective, multicentre COMBAT study, 2001 Dutch travellers and 215 non-travelling household members were enrolled...
October 14, 2016: Lancet Infectious Diseases
Laurynas Pasakarnis, Erich Frei, Emmanuel Caussinus, Markus Affolter, Damian Brunner
Tissue morphogenesis requires coordination of multiple force-producing components. During dorsal closure in fly embryogenesis, an epidermis opening closes. A tensioned epidermal actin/MyosinII cable, which surrounds the opening, produces a force that is thought to combine with another MyosinII force mediating apical constriction of the amnioserosa cells that fill the opening. A model proposing that each force could autonomously drive dorsal closure was recently challenged by a model in which the two forces combine in a ratchet mechanism...
October 17, 2016: Nature Cell Biology
Hayaki Uchino, Akira Kuriyama, John Bruce, Grant Laing, Damian Clarke, George Oosthuizen
Dog bites are a major cause of injury, especially in the pediatric population. Common anatomic sites of dog bites on children are the peripheries and the head and neck. The torso is reportedly injured less frequently, and only 2 cases of intra-abdominal injury secondary to dog bites have been reported. We recently encountered a 3-year-old boy presenting with peritonitis who had sustained multiple dog bites to his trunk and upper limbs. Emergency laparotomy was performed. Surgical findings revealed penetration of the peritoneum and single perforation of the anterior gastric wall with multiple tooth marks; thus, the gastric perforation was debrided and repaired...
September 30, 2016: Pediatric Emergency Care
Matthew J Mimiaga, Elizabeth F Closson, Shanice Battle, Jeffrey H Herbst, Damian Denson, Nicole Pitts, Jeremy Holman, Stewart Landers, Gordon Mansergh
Men who have sex with men (MSM) of color are disproportionately affected by HIV in the United States. Pre-exposure prophylaxis (PrEP) using antiretroviral medications is a newer biomedical prevention modality with established efficacy for reducing the risk of acquiring HIV. We conducted formative qualitative research to explore audience reactions and receptivity to message concepts on PrEP as part of the development of prevention messages to promote PrEP awareness among black and Latino MSM in the United States...
October 2016: AIDS Patient Care and STDs
Paul S Shamble, Gil Menda, James R Golden, Eyal I Nitzany, Katherine Walden, Tsevi Beatus, Damian O Elias, Itai Cohen, Ronald N Miles, Ronald R Hoy
Jumping spiders (Salticidae) are famous for their visually driven behaviors [1]. Here, however, we present behavioral and neurophysiological evidence that these animals also perceive and respond to airborne acoustic stimuli, even when the distance between the animal and the sound source is relatively large (∼3 m) and with stimulus amplitudes at the position of the spider of ∼65 dB sound pressure level (SPL). Behavioral experiments with the jumping spider Phidippus audax reveal that these animals respond to low-frequency sounds (80 Hz; 65 dB SPL) by freezing-a common anti-predatory behavior characteristic of an acoustic startle response...
October 6, 2016: Current Biology: CB
Deborah Q Shelef, Cynthia Rand, Randi Streisand, Ivor B Horn, Kabir Yadav, Lisa Stewart, Naja Foushee, Damian Waters, Stephen J Teach
BACKGROUND: Stakeholder engagement has the potential to develop research interventions which are responsive to patient and provider preferences. This approach contrasts with traditional models of clinical research, in which researchers determine the study's design. OBJECTIVE: This article describes the impact of stakeholder engagement on the design of a randomized trial of an intervention designed to improve child asthma outcomes by reducing parental stress. METHODS: The study team developed and implemented a stakeholder engagement process that provided iterative feedback regarding the study design, patient-centered outcomes, and intervention...
October 12, 2016: Journal of Allergy and Clinical Immunology
William F Weiss, John P Gabrielson, Wasfi Al-Azzam, Guodong Chen, Darryl L Davis, Tapan K Das, David B Hayes, Damian Houde, Satish K Singh
Characterization of the higher order structure (HOS) of protein-based biopharmaceutical products is an important aspect of their development. Opinions vary about how best to apply biophysical methods, in which contexts to use these methods, and how to use the resulting data to make technical decisions as drug candidates are commercialized [Gabrielson JP, Weiss WF IV. J Pharm Sci. 2015;104(4):1240-1245]. The aim of this commentary is to provide guidance for the development and implementation of a robust and comprehensive HOS characterization strategy...
October 12, 2016: Journal of Pharmaceutical Sciences
Farhood Saremi, Cameron Hassani, Damián Sánchez-Quintana
The septal atrioventricular junction is a centrally located region of the heart where the septal components of the atria and ventricles meet the aortic, mitral, and tricuspid valves. Important structures in this region include the membranous septum, the central fibrous body, the Koch triangle, the inferior pyramidal space, and the base of the interventricular septum. This small area is the home of the atrioventricular node and the atrioventricular conduction axis and has enormous importance to electrophysiologists owing to its prime role in the conduction system of the heart...
October 14, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Damian Roland, Sam Jones, Tim Coats, Ffion Davies
BACKGROUND: Increasing utilisation of Emergency and Acute Care services by children and young people is a worldwide trend. This is thought to be a result of parent and carer desire for more "on demand" health care assessment and not a consequence of increasing severity of disease. A bespoke acuity assessment system in our department allowed us to test this hypothesis. METHODS: This data is based on the Paediatric Observation Priority Score, a previously published and validated assessment tool designed specifically for Paediatric Emergency Care [1]...
October 14, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Dan W Teng, Charles L Eddy, Damian G Kelty-Stephen
Blindwalking to replicate an instructed distance requires various sensory signals. Recent evidence in movement science across many organisms suggests that multifractal organization of connective tissue supports the use of these signals. Multifractal structure is a multiplicity of power laws defining distribution of proportion across many time scales that helps predict judgments of the objects' length. Present work tests whether the multifractal structure in postural accelerometry during blindwalking predicts blindwalking distance replications...
October 14, 2016: Attention, Perception & Psychophysics
Roger A Levy, Renato Guzman, Gilberto Castañeda-Hernández, Manuel Martinez-Vazquez, Guilherme Damian, Carlos Cara
Biologics are increasingly being used to modify the course of immune-mediated inflammatory diseases. Some main agents are monoclonal antibodies and a fusion-protein that target TNF. This group includes adalimumab, infliximab, certolizumab pegol, golimumab and etanercept. Although the efficacy of anti-TNFs is supported by numerous randomized clinical trials, their pharmacokinetics depend on many factors, in particular immunogenicity, which can cause marked and rapid clearance and a consequent decrease in efficacy...
October 14, 2016: Immunotherapy
Gemma V Clucas, Jane L Younger, Damian Kao, Alex D Rogers, Jonathan Handley, Gary D Miller, Pierre Jouventin, Paul Nolan, Karim Gharbi, Karen J Miller, Tom Hart
BACKGROUND: Seabirds are important components of marine ecosystems, both as predators and as indicators of ecological change, being conspicuous and sensitive to changes in prey abundance. To determine whether fluctuations in population sizes are localised or indicative of large-scale ecosystem change, we must first understand population structure and dispersal. King penguins are long-lived seabirds that occupy a niche across the sub-Antarctic zone close to the Polar Front. Colonies have very different histories of exploitation, population recovery, and expansion...
October 13, 2016: BMC Evolutionary Biology
Emilie Vallières, Jacqueline C Rendall, John E Moore, John McCaughan, Anne I Hoeritzauer, Michael M Tunney, Joseph Stuart Elborn, Damian G Downey
UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples. As there is no clear consensus as to which eradication regimen is most effective, we determined the efficacy of eradication regimens used in our CF centre and long-term clinical outcome. All new MRSA positive sputum cultures (n=37) that occurred between 2000 and 2014 were reviewed. Eradication regimen characteristics and clinical, microbiological and long-term outcome data were collected...
January 2016: ERJ Open Research
Alex R Horsley, Katherine O'Neill, Damian G Downey, J Stuart Elborn, Nicholas J Bell, Jaclyn Smith, John Owers-Bradley
Multiple breath wash-out (MBW) testing requires prior wash-in of inert tracer gas. Wash-in efficiency can be enhanced by a rebreathing tracer in a closed circuit. Previous attempts to deploy this did not account for the impact of CO2 accumulation on patients and were unsuccessful. We hypothesised that an effective rebreathe wash-in could be delivered and it would not alter wash-out parameters. Computer modelling was used to assess the impact of the rebreathe method on wash-in efficiency. Clinical testing of open and closed circuit wash-in-wash-out was performed in healthy controls and adult patients with cystic fibrosis (CF) using a circuit with an effective CO2 scrubber and a refined wash-in protocol...
January 2016: ERJ Open Research
Salvador Damián-Zamacona, Paola Toledo-Ibelles, Mabel Z Ibarra-Abundis, Laura Uribe-Figueroa, Enrique Hernández-Lemus, Karla Paola Macedo-Alcibia, Blanca Delgado-Coello, Jaime Mas-Oliva, Juan Pablo Reyes-Grajeda
BACKGROUND: Although nowadays it is well known that the human transcriptome can importantly vary according to external or environmental condition, the reflection of this concept when studying oxidative stress and its direct relationship with gene expression profiling during the process of atherogenesis has not been thoroughly achieved. OBJECTIVE: The ability to analyze genome-wide gene expression through transcriptomics has shown that the genome responds dynamically to diverse stimuli...
2016: PloS One
Mariusz Mogielnicki, Damian Swieczkowski, Witold Bachorski, Grzegorz Zuk, Natasza Gilis-Malinowska, Aleksander Zarzeka, Piotr Merks, Marcin Gruchala, Milosz Jaguszewski
No abstract text is available yet for this article.
2016: Cardiology Journal
Darío Villalba, Viviana Feld, Valeria Leiva, Mariana Scrigna, Eduardo Distéfano, Romina Pratto, Matías Rodriguez, Jesica Collins, Ana Rocco, Amelia Matesa, Damián Rossi, Laura Areas, Sacha Virgilio, Nicolás Golfarini, Gregorio Gil-Rosetti, Pablo Diaz-Ballve, Fernando Planells
OBJECTIVE: To describe and compare the work of breathing (WOB) during spontaneous breathing under four conditions: (1) breathing through a tracheostomy tube with an inflated cuff, (2) breathing through the upper airway (UA) with a deflated cuff and occluded tube, (3) breathing through the UA with an occluded cuffless tube, and (4) postdecannulation. PATIENTS AND METHODS: Patients who tolerated an occluded cuffless tube were included. Ventilatory variables and esophageal pressure were recorded...
July 2016: International Journal of Critical Illness and Injury Science
Rita Diehl, Fabienne Ferrara, Claudia Müller, Antje Y Dreyer, Damian D McLeod, Stephan Fricke, Johannes Boltze
Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species. Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation...
October 10, 2016: Cellular & Molecular Immunology
Jean-Pierre Schaller, Daniela Keller, Laurent Poget, Pascal Pratte, Etienne Kaelin, Damian McHugh, Gianluca Cudazzo, Daniel Smart, Anthony R Tricker, Lydia Gautier, Michel Yerly, Roger Reis Pires, Soazig Le Bouhellec, David Ghosh, Iris Hofer, Eva Garcia, Patrick Vanscheeuwijck, Serge Maeder
The chemical composition, in vitro genotoxicity, and cytotoxicity of the mainstream aerosol from the Tobacco Heating System 2.2 (THS2.2) were compared with those of the mainstream smoke from the 3R4F reference cigarette. In contrast to the 3R4F, the tobacco plug in the THS2.2 is not burnt. The low operating temperature of THS2.2 caused distinct shifts in the aerosol composition compared with 3R4F. This resulted in a reduction of more than 90% for the majority of the analyzed harmful and potentially harmful constituents (HPHCs), while the mass median aerodynamic diameter of the aerosol remained similar...
October 6, 2016: Regulatory Toxicology and Pharmacology: RTP
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