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https://www.readbyqxmd.com/read/29453830/eosinophilic-polymorphic-and-pruritic-eruption-associated-with-radiotherapy-in-a-patient-with-primary-nodal-merkel-cell-carcinoma
#1
Wedad Abdelrahman, Lin Shum, Damian McManus, Maureen Y Walsh, Olivia Dolan
No abstract text is available yet for this article.
February 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29450138/biological-activities-of-frankincense-essential-oil-in-human-dermal-fibroblasts
#2
Xuesheng Han, Damian Rodriguez, Tory L Parker
Although frankincense essential oil (FREO) has become increasingly popular in skin care, research on its biological activities in human skin cells is scarce, if not completely absent. In the current study, we explored the biological activities of FREO in pre-inflamed human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. FREO exhibited robust anti-proliferative activity in these skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1...
June 2017: Biochimie Open
https://www.readbyqxmd.com/read/29447845/probing-gaba-a-receptors-with-inhibitory-neurosteroids
#3
REVIEW
Sandra Seljeset, Damian P Bright, Philip Thomas, Trevor G Smart
γ-aminobutyric acid type A receptors (GABA A Rs) are important components of the central nervous system and they are functionally tasked with controlling neuronal excitability. These receptors are subject to post-translational modification and also to modulation by endogenous regulators, such as the neurosteroids. These modulators can either potentiate or inhibit GABA A R function. Whilst the former class of neurosteroids are considered to bind to and act from the transmembrane domain of the receptor, the domains that are important for the inhibitory neurosteroids remain less clear...
February 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29446825/phytomedicines-medicines-derived-from-plants-for-sickle-cell-disease
#4
REVIEW
Oluseyi Oniyangi, Damian H Cohall
BACKGROUND: Sickle cell disease, a common recessively inherited haemoglobin disorder, affects people from sub-Saharan Africa, the Middle East, Mediterranean basin, Indian subcontinent, Caribbean and South America. It is associated with complications and a reduced life expectancy. Phytomedicines (medicine derived from plants in their original state) encompass many of the plant remedies from traditional healers which the populations most affected would encounter. Laboratory research and limited clinical trials have suggested positive effects of phytomedicines both in vivo and in vitro...
February 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29445453/the-european-falsified-medicines-directive-in-poland-background-implementation-and-potential-recommendations-for-pharmacists
#5
Piotr Merks, Damian Swieczkowski, Michal Byliniak, Mariola Drozd, Katarzyna Krupa, Milosz Jaguszewski, David A Brindley, Bernard D Naughton
By February 2019, the Polish pharmaceutical industry, community and hospital pharmacies, wholesalers and parallel traders must all comply with the EU-wide Falsified Medicines Directive (FMD) legislation (2011/62/EU), to ensure that no medicinal product is dispensed to a patient without proper tracking and authentication. Here we describe how Poland is complying with the new EU regulations, the actions that have been taken to incorporate the FMD into Polish Pharmaceutical Law and whether or not these actions are sufficient...
January 2018: European Journal of Hospital Pharmacy. Science and Practice
https://www.readbyqxmd.com/read/29445348/taekwondo-fighting-in-training-does-not-simulate-the-affective-and-cognitive-demands-of-competition-implications-for-behavior-and-transfer
#6
Michael A Maloney, Ian Renshaw, Jonathon Headrick, David T Martin, Damian Farrow
Enhancing practice design is critical to facilitate transfer of learning. Considerable research has focused on the role of perceptual information in practice simulation, yet has neglected how affect and cognition are shaped by practice environments and whether this influences the fidelity of behavior (Headrick et al., 2015). This study filled this gap by examining the fidelity of individual (cognition, affect, and actions) and interpersonal behavior of 10 highly skilled Australian Taekwondo athletes fighting in training compared to competition...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29440480/trismus-caused-by-paraneoplastic-brainstem-encephalitis
#7
Naveed Malek, Maxwell Damian
We discuss the assessment and differential diagnoses of a middle-aged man who presented with trismus, double vision and behavioural problems. MRI scan of the brain was initially normal, but a month later showed high signal in the hippocampal region on fluid attenuated inversion recovery sequence (FLAIR) imaging. We suspected a paraneoplastic brainstem encephalitis because of his smoking history, rapidly progressive symptoms and abnormal brainstem signs. A positron emission tomography-CT scan identified abnormal subcarinal nodes, shown on biopsy to be metastatic small cell lung cancer...
February 13, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29440071/non-invasive-immuno-metabolic-cardiac-inflammation-imaging-using-hyperpolarized-magnetic-resonance
#8
Andrew J Lewis, Jack J Miller, Angus Z Lau, Mary K Curtis, Oliver J Rider, Robin P Choudhury, Stefan Neubauer, Charles H Cunningham, Carolyn A Carr, Damian J Tyler
<u>Rationale:</u> Current cardiovascular clinical imaging techniques offer only limited assessment of innate immune cell driven inflammation, which is a potential therapeutic target in myocardial infarction (MI) and other diseases. Hyperpolarized magnetic resonance (MR) is an emerging imaging technology that generates contrast agents with 10-20,000 fold improvements in MR signal, enabling cardiac metabolite mapping. <u>Objective:</u> To determine whether hyperpolarized MR using [1- 13 C]pyruvate can assess the local cardiac inflammatory response following MI...
February 12, 2018: Circulation Research
https://www.readbyqxmd.com/read/29438473/in-uncontrolled-diabetes-hyperglucagonemia-and-ketosis-result-from-deficient-leptin-action-in-the-parabrachial-nucleus
#9
Thomas H Meek, Miles E Matsen, Chelsea L Faber, Colby L Samstag, Vincent Damian, Hong T Nguyen, Jarrad M Scarlett, Jonathan N Flak, Martin G Myers, Gregory J Morton
Growing evidence implicates neurons that project from the lateral parabrachial nucleus (LPBN) to the hypothalamic ventromedial nucleus (VMN) in a neurocircuit that drives counterregulatory responses to hypoglycemia, including increased glucagon secretion. Among LPBN neurons in this circuit is a subset that expresses cholecystokinin (LPBNCCK neurons) and is tonically inhibited by leptin. Since uncontrolled diabetes is associated with both leptin deficiency and hyperglucagonemia, and since intracerebroventricular (icv) leptin administration reverses both hyperglycemia and hyperglucagonemia in this setting, we hypothesized that deficient leptin inhibition of LPBNCCK neurons drives activation of this LPBN→VMN circuit and thereby results in hyperglucagonemia...
February 8, 2018: Endocrinology
https://www.readbyqxmd.com/read/29438066/cardiomyocyte-diffusible-redox-mediators-control-trypanosoma-cruzi-infection-role-of-parasite-mitochondrial-iron-superoxide-dismutase
#10
Damian Estrada, Gabriela Specker, Alejandra Martinez, Patricia Pereira Silva, Barbara Hissa, Luciana O Andrade, Rafael Radi, Lucía Piacenza
Chagas disease (CD), caused by the protozoa Trypanosoma cruzi , is a chronic illness in which parasites persist in the host-infected tissues for years. T. cruzi invasion in cardiomyocytes elicits the production of pro-inflammatory mediators (TNF-α, IL-1β, IFNγ; nitric oxide ( • NO)) leading to mitochondrial dysfunction with increase superoxide radical (O 2 •- ), hydrogen peroxide (H 2 O 2 ) and peroxynitrite generation. We hypothesize that these redox-mediators may control parasite proliferation through the induction of intracellular amastigote programmed cell death (PCD)...
February 7, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29437277/identification-of-native-and-post-translationally-modified-hla-b-57-01-restricted-hiv-envelope-derived-epitopes-using-immunoproteomics
#11
Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda W S Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane Thomas, Stephen J Kent, Nicola Ternette, Damian F J Purcell, Jamie Rossjohn, Anthony W Purcell
The recognition of pathogen-derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the endoplasmic reticulum (ER). These peptide-HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T-cells leading to the eradication of the infected cell. Here we identify naturally presented HLA-B*57:01 bound peptides derived from the envelope protein of the human immunodeficiency virus (HIVenv)...
February 13, 2018: Proteomics
https://www.readbyqxmd.com/read/29437150/pp2a-inhibition-sensitizes-cancer-stem-cells-to-abl-tyrosine-kinase-inhibitors-in-bcr-abl-human-leukemia
#12
Damian Lai, Min Chen, Jiechuang Su, Xiaohu Liu, Katharina Rothe, Kaiji Hu, Donna L Forrest, Connie J Eaves, Gregg B Morin, Xiaoyan Jiang
Overcoming drug resistance and targeting leukemic stem cells (LSCs) remain major challenges in curing BCR-ABL+human leukemia. Using an advanced drug/proliferation screen, we have uncovered a prosurvival role for protein phosphatase 2A (PP2A) in tyrosine kinase inhibitor (TKI)-insensitive leukemic cells, regulated by an Abelson helper integration site-1-mediated PP2A-β-catenin-BCR-ABL-JAK2 protein complex. Genetic and pharmacological inhibition of PP2A impairs survival of TKI nonresponder cells and sensitizes them to TKIs in vitro, inducing a dramatic loss of several key proteins, including β-catenin...
February 7, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29433822/tetrafluoroterephthalonitrile-crosslinked-%C3%AE-cyclodextrin-polymers-for-efficient-extraction-and-recovery-of-organic-micropollutants-from-water
#13
Chenjun Li, Max J Klemes, William R Dichtel, Damian E Helbling
In this study, we evaluated the performance of a novel tetrafluoroterephthalonitrile-crosslinked β-cyclodextrin polymer (TFN-CDP) as a solid-phase extraction (SPE) material for the recovery of up to 189 diverse organic micropollutants (MPs) from water. The optimized extraction procedure requires loading of water samples adjusted to a pH of 3 onto 500 mg of TFN-CDP packed into an SPE cartridge. Under these conditions, 88.7% of the MPs have average extraction efficiencies greater than 80%. The optimized recovery procedure requires elution with 15 mL of methanol amended with 15 mg of calcium chloride...
February 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29432445/promising-effects-of-xanthine-oxidase-inhibition-by-allopurinol-on-autonomic-heart-regulation-estimated-by-heart-rate-variability-hrv-analysis-in-rats-exposed-to-hypoxia-and-hyperoxia
#14
Stanisław Zajączkowski, Wiesław Ziółkowski, Piotr Badtke, Miłosz A Zajączkowski, Damian J Flis, Adam Figarski, Maria Smolińska-Bylańska, Tomasz H Wierzba
BACKGROUND: It has long been suggested that reactive oxygen species (ROS) play a role in oxygen sensing via peripheral chemoreceptors, which would imply their involvement in chemoreflex activation and autonomic regulation of heart rate. We hypothesize that antioxidant affect neurogenic cardiovascular regulation through activation of chemoreflex which results in increased control of sympathetic mechanism regulating heart rhythm. Activity of xanthine oxidase (XO), which is among the major endogenous sources of ROS in the rat has been shown to increase during hypoxia promote oxidative stress...
2018: PloS One
https://www.readbyqxmd.com/read/29431824/correction-colchicine-metallocenyl-bioconjugates-showing-high-antiproliferative-activities-against-cancer-cell-lines
#15
Karolina Kowalczyk, Andrzej Błauż, Wojciech M Ciszewski, Anna Wieczorek, Błażej Rychlik, Damian Plażuk
Correction for 'Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines' by Karolina Kowalczyk et al., Dalton Trans., 2017, 46, 17041-17052.
February 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29431484/striatal-hand-in-a-woman-with-parkinson-s-disease
#16
Tian Meng, Damian Bruce-Hickman
No abstract text is available yet for this article.
February 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29429841/modification-of-clinically-short-locator-abutments-using-laser-welding
#17
Faris Z Jamjoom, Damian J Lee
As dental implants continue to survive longer, managing and maintaining implant prostheses can be complicated by the lack of compatible parts or the discontinuation of implant systems. This report describes a laser welding procedure for the management of clinically short Locator abutments (Zest Anchors Inc) that lacked a commercially available, compatible alternative.
February 8, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29428450/physicians-working-under-the-influence-of-alcohol-an-analysis-of-past-disciplinary-proceedings-and-their-outcomes
#18
Damian Jacob Sendler
INTRODUCTION: The intoxicated person may cause harm to others, often requiring expert evaluation for the determination of guilt. The primary aim of this study was to determine the mechanisms of mistakes that led 17 doctors accused of working under the influence of alcohol to face malpractice. We also wanted to clarify what were the legal, professional, and financial consequences - depending on specific patient outcomes. METHOD: We based analysis on the review and meta-analysis of the past forensic evaluation reports of institution-run forensics programs...
February 5, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29427527/ubc-nepal-expedition-the-use-of-oral-antioxidants-does-not-alter-cerebrovascular-function-at-sea-level-or-high-altitude
#19
Alex B Hansen, Ryan L Hoiland, Nia C S Lewis, Michael M Tymko, Joshua C Tremblay, Michael Stembridge, Daniela Nowak-Flück, Howard H Carter, Damian M Bailey, Philip N Ainslie
Hypoxia is associated with an increased systemic and cerebral formation of free radicals and associated reactants that may be linked to impaired cerebral vascular function a neurological sequela. To what extent oral antioxidants prophylaxis impacts cerebrovascular function in humans throughout the course of acclimatization to the hypoxia of terrestrial high-altitude has not been examined. Thus, the purpose of the current study was to examine the influence of orally ingested antioxidants at clinically relevant doses (vitamin C, E, and alpha-lipoic acid) on cerebrovascular regulation at sea-level (344 m; n = 12; female n = 2 participants), and at high altitude (5050 m; n = 9; female n = 2), in a randomized, placebo-controlled, and double-blinded crossover design...
February 10, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29426813/the-use-of-communication-apps-by-medical-staff-in-the-australian-health-care-system-survey-study-on-prevalence-and-use
#20
Amanda Nikolic, Nilmini Wickramasinghe, Damian Claydon-Platt, Vikram Balakrishnan, Philip Smart
BACKGROUND: The use of communication apps on mobile phones offers an efficient, unobtrusive, and portable mode of communication for medical staff. The potential enhancements in patient care and education appear significant, with clinical details able to be shared quickly within multidisciplinary teams, supporting rapid integration of disparate information, and more efficient patient care. However, sharing patient data in this way also raises legal and ethical issues. No data is currently available demonstrating how widespread the use of these apps are, doctor's attitudes towards them, or what guides clinician choice of app...
February 9, 2018: JMIR Medical Informatics
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