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https://www.readbyqxmd.com/read/29792359/adverse-effect-analysis-of-high-intensity-focused-ultrasound-in-the-treatment-of-benign-uterine-diseases
#1
Yunchang Liu, Wendy Wenyi Zhang, Min He, Chunmei Gong, Bin Xie, Xiangxia Wen, Dandan Li, Lian Zhang
OBJECTIVE: To retrospectively analyze the adverse effects of high-intensity focused ultrasound (HIFU) in management of benign uterine diseases. MATERIALS AND METHODS: From 2011 to 2017, 27,053 patients with benign uterine diseases were treated with HIFU in 19 centers in China. Among them, 17,402 patients had uterine fibroids, 8434 had adenomyosis, 876 had caesarean scar pregnancies, and 341 had placenta accreta. RESULTS: The median age, height, weight, BMI of the patients was 42 years, 158 mm, 56 kg, 22...
May 24, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29792052/randomized-clinical-trial-of-computerized-and-clinician-delivered-cbt-in-comparison-with-standard-outpatient-treatment-for-substance-use-disorders-primary-within-treatment-and-follow-up-outcomes
#2
Brian D Kiluk, Charla Nich, Matthew B Buck, Kathleen A Devore, Tami L Frankforter, Donna M LaPaglia, Srinivas B Muvvala, Kathleen M Carroll
OBJECTIVE: Previous trials have demonstrated the efficacy and durability of computer-based cognitive-behavioral therapy (CBT4CBT) as an add-on to standard outpatient care in a range of treatment-seeking populations. In this study, the authors evaluated the efficacy and safety of CBT4CBT as a virtual stand-alone treatment, delivered with minimal clinical monitoring, and clinician-delivered cognitive-behavioral therapy (CBT) compared with treatment as usual in a heterogeneous sample of treatment-seeking outpatients with substance use disorders...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29789890/surveillance-magnetic-resonance-imaging-for-isolated-optic-pathway-gliomas-is-gadolinium-necessary
#3
Ezekiel Maloney, A Luana Stanescu, Francisco A Perez, Ramesh S Iyer, Randolph K Otto, Sarah Leary, Lotte Steuten, Amanda I Phipps, Dennis W W Shaw
BACKGROUND: Pediatric optic pathway gliomas are typically indolent but have a variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced MRI examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast agents. OBJECTIVES: To determine surveillance MR factors that motivate changes in tumor-directed therapies and extrapolate cost-efficacy of a non-contrast follow-up protocol. MATERIALS AND METHODS: Using an imaging database search we identified children with isolated optic pathway gliomas and ≥3 follow-up contrast-enhanced MRIs...
May 22, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29789764/a-single-institution-analysis-of-low-dose-rate-brachytherapy-5-year-reported-survival-and-late-toxicity-outcomes
#4
REVIEW
Michael Chao, Sandra Spencer, Mario Guerrieri, Wei Ding, Mehran Goharian, Huong Ho, Michael Ng, Danielle Healey, Alwin Tan, Chee Cham, Daryl Lim Joon, Nathan Lawrentschuk, Douglas Travis, Shomik Sengupta, Yee Chan, Andrew Troy, Trung Pham, David Clarke, Peter Liodakis, Damien Bolton
Purpose: To report the 5-year biochemical relapse-free survival (BRFS), overall survival (OS), and long-term toxicity outcomes of patients treated with low-dose-rate (LDR) brachytherapy as monotherapy for low- to intermediate-risk prostate cancer. Material and methods: Between 2004 and 2011, 371 patients were treated with LDR brachytherapy as monotherapy. Of these, 102 patients (27%) underwent transurethral resection of the prostate (TURP) prior to implantation...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789581/intron-retention-and-nuclear-loss-of-sfpq-are-molecular-hallmarks-of-als
#5
Raphaelle Luisier, Giulia E Tyzack, Claire E Hall, Jamie S Mitchell, Helen Devine, Doaa M Taha, Bilal Malik, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M Luscombe, Rickie Patani
Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously expressed regulators of RNA processing. To understand the molecular impact of ALS-causing mutations on neuronal development and disease, we analysed transcriptomes during in vitro differentiation of motor neurons (MNs) from human control and patient-specific VCP mutant induced-pluripotent stem cells (iPSCs). We identify increased intron retention (IR) as a dominant feature of the splicing programme during early neural differentiation...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789237/predictors-of-biochemical-recurrence-after-radical-prostatectomy-in-an-afro-caribbean-population-in-guadeloupe-french-west-indies
#6
L Brureau, E Emeville, L Multigner, P Blanchet
PURPOSE: Few studies have investigated predictive risk factors of biochemical recurrence (BCR) after radical prostatectomy (RP) in other than Caucasian and Asian populations. We aimed to identify pre- and post-operative predictors of BCR after RP in an Afro-Caribbean population in Guadeloupe (French West Indies). PATIENTS AND METHODS: The study included 964 patients who underwent RP for clinically localized prostate cancer between April 1, 2000 and December 31, 2010 in the University Hospital of Guadeloupe...
May 20, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29788201/genetic-variants-in-autism-related-cntnap2-impair-axonal-growth-of-cortical-neurons
#7
Giorgia Canali, Marta Garcia, Bruno Hivert, Delphine Pinatel, Aline Goullancourt, Ksenia Oguievetskaia, Margaux Saint-Martin, Jean-Antoine Girault, Catherine Faivre-Sarrailh, Laurence Goutebroze
The CNTNAP2 gene, coding for the cell adhesion glycoprotein Caspr2, is thought to be one of the major susceptibility genes for autism spectrum disorder (ASD). A large number of rare heterozygous missense CNTNAP2 variants have been identified in ASD patients. However, most of them are inherited from an unaffected parent, questioning their clinical significance. In the present study, we evaluate their impact on neurodevelopmental functions of Caspr2 in a heterozygous genetic background. Performing cortical neuron cultures from mouse embryos, we demonstrate that Caspr2 plays a dose-dependent role in axon growth in vitro...
June 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29788148/the-role-of-angiogenesis-inhibitors-in-hypertension-following-ariadne-s-thread
#8
Elias Sanidas, Dimitris P Papadopoulos, Maria Velliou, Kostas Tsioufis, Marina Mantzourani, Dimitris Iliopoulos, Despoina Perrea, John Barbetseas, Vasilios Papademetriou
Arterial hypertension (HT) is one of the most frequently recorded comorbidities among patients under antiangiogenic therapy. Inhibitors of vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR) are most commonly involved in new onset or exacerbation of pre-existing controlled HT. From the pathophysiology point of view, data support that reduced nitric oxide release and sodium and fluid retention, microvascular rarefaction, elevated vasoconstrictor levels and globular injury might contribute to HT...
May 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29786037/preliminary-outcome-of-individualized-abdominoperineal-excision-for-locally-advanced-low-rectal-cancer
#9
Yi Zheng, Jia-Gang Han, Zhen-Jun Wang, Zhi-Gang Gao, Guang-Hui Wei, Zhi-Wei Zhai, Bao-Cheng Zhao
Background: The introduction of individualized abdominoperineal excision (APE) may minimize operative trauma and reduce the rate of complications. The purpose of this study was to evaluate the safety and efficacy of individualized APE for low rectal cancer. Methods: Fifty-six patients who underwent individualized APE from June 2011 to June 2015 were evaluated retrospectively in Beijing Chaoyang Hospital, Capital Medical University. The main outcome measures were circumferential resection margin (CRM) involvement, intraoperative perforation, postoperative complications, and local recurrence...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785109/development-and-characterization-of-a-nanoemulsion-containing-propranolol-for-topical-delivery
#10
Tatiana Zanela da Silva Marques, Ralph Santos-Oliveira, Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Zaida Maria Faria de Freitas, Rita de Cássia da Silva Ascenção Barros, Ana Lúcia Vazquez Villa, Mariana Sato de Souza de Bustamante Monteiro, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
Background: Propranolol (PPN) is a therapeutic option for the treatment of infantile hemangiomas. This study aimed at the development of nanoemulsion (NE) containing 1% PPN, characterization of the system, and safety studies based on ex vivo permeation, cytotoxicity, and biodistribution in vivo. Methods: The formulation was developed and characterized in relation to the droplet size, polydispersity index (PDI), pH, zeta potential, and electronic microscopy. Ex vivo permeation studies were used to evaluate the cutaneous retention of PPN in the epidermis and dermis...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29784537/artificial-intelligence-a-joint-narrative-on-potential-use-in-pediatric-stem-and-immune-cell-therapies-and-regenerative-medicine
#11
REVIEW
Irena Sniecinski, Jerard Seghatchian
Artificial Intelligence (AI) reflects the intelligence exhibited by machines and software. It is a highly desirable academic field of many current fields of studies. Leading AI researchers describe the field as "the study and design of intelligent agents". McCarthy invented this term in 1955 and defined it as "the science and engineering of making intelligent machines". The central goals of AI research are reasoning, knowledge, planning, learning, natural language processing (communication), perception and the ability to move and manipulate objects...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29784167/outcomes-of-boston-keratoprosthesis-type-1-reimplantation-multicentre-study-results
#12
Jay C Wang, Christopher J Rudnisky, Michael W Belin, Joseph B Ciolino
OBJECTIVE: To investigate the visual and anatomical outcomes of Boston keratoprosthesis (Kpro) type 1 reimplantation. DESIGN: Subgroup analysis of multicentre prospective cohort study. PARTICIPANTS: Of 303 eyes that underwent Kpro implantation between January 2003 and July 2008 by 1 of 19 surgeons at 18 medical centres, 13 eyes of 13 patients who underwent reimplantation of Boston Kpro type 1 were compared with 13 eyes of 13 diagnosis-matched patients who underwent initial implantation...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29782398/benefit-and-harm-of-adding-epinephrine-to-a-local-anesthetic-for-neuraxial-and-locoregional-anesthesia-a-meta-analysis-of-randomized-controlled-trials-with-trial-sequential-analyses
#13
Clément Tschopp, Martin R Tramèr, Alexis Schneider, Maroun Zaarour, Nadia Elia
BACKGROUND: This systematic review examines the benefit and harm of adding epinephrine to local anesthetics for epidural, intrathecal, or locoregional anesthesia. METHODS: We searched electronic databases to October 2017 for randomized trials comparing any local anesthetic regimen combined with epinephrine, with the same local anesthetic regimen without epinephrine, reporting on duration of analgesia, time to 2 segments regression, or any adverse effects. Trial quality was assessed using the Cochrane risk of bias tool and a random-effects model was used...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29782222/clinical-effectiveness-of-a-resin-modified-glass-ionomer-cement-and-a-mild-one-step-self-etch-adhesive-applied-actively-and-passively-in-noncarious-cervical-lesions-an-18-month-clinical-trial
#14
M Jassal, S Mittal, S Tewari
OBJECTIVES: To evaluate the clinical effectiveness of two methods of application of a mild one-step self-etch adhesive and composite resin as compared with a resin-modified glass ionomer cement (RMGIC) control restoration in noncarious cervical lesions (NCCLs). METHODS: A total of 294 restorations were placed in 56 patients, 98 in each one of the following groups: 1) G-Bond active application combined with Solare-X composite resin (A-1SEA), 2) G-Bond passive application combined with Solare-X composite resin (P-1SEA), and 3) GC II LC RMGIC...
May 21, 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29781925/osteo-odonto-keratoprosthesis-in-severe-thermal-and-chemical-injuries
#15
Alfonso Vasquez-Perez, Mehran Zarei-Ghanavati, Venkata Avadhanam, Christopher Liu
PURPOSE: To report the results of osteo-odonto-keratoprosthesis (OOKP) surgery in patients who sustained severe chemical and thermal injuries. METHODS: This is a noncomparative retrospective case series of 14 patients who underwent OOKP surgery between 2001 and 2016 at the Sussex Eye Hospital, Brighton, UK, because of severe chemical and thermal injuries RESULTS:: OOKP surgery was performed in 14 eyes of 14 patients. Eight patients (57%) sustained thermal injuries and 6 patients (43%) chemical injuries...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29781687/assessment-of-nurses-cardiopulmonary-resuscitation-knowledge-and-skills-within-three-district-hospitals-in-botswana
#16
Lakshmi Rajeswaran, Megan Cox, Stoffel Moeng, Billy M Tsima
BACKGROUND:  Nurses are usually the first to identify the need for and initiate cardiopulmonary resuscitation (CPR) on patients with cardiopulmonary arrest in the hospital setting. Cardiopulmonary resuscitation has been shown to reduce in-hospital deaths when received from adequately trained health care professionals. AIM:  We aimed to investigate nurses' retention of CPR knowledge and skills at district hospitals in Botswana. METHODS:  A quantitative, quasi-experimental study was conducted at three hospitals in Botswana...
April 12, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29781655/mental-health-and-retention-in-hiv-care-a-systematic-review-and-meta-analysis
#17
Cherie R Rooks-Peck, Adebukola H Adegbite, Megan E Wichser, Rebecca Ramshaw, Mary M Mullins, Darrel Higa, Theresa Ann Sipe
OBJECTIVE: Mental health (MH) diagnoses, which are prevalent among persons living with HIV infection, might be linked to failed retention in HIV care. This review synthesized the quantitative evidence regarding associations between MH diagnoses or symptoms and retention in HIV care, as well as determined if MH service utilization (MHSU) is associated with improved retention in HIV care. METHOD: A comprehensive search of the Centers for Disease Control and Prevention's HIV/AIDS Prevention Research Synthesis database of electronic (e...
June 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29781378/art-attrition-across-health-facilities-implementing-option-b-in-haiti
#18
Martine Pamphile Myrtil, Nancy Puttkammer, Stephen Gloyd, Julia Robinson, Krista Yuhas, Jean Wysler Domercant, Jean Guy Honoré, Kesner Francois
BACKGROUND: Describing factors related to high attrition is important in order to improve the implementation of the Option B+ strategy in Haiti. METHODS: We conducted a retrospective cohort study to describe the variability of antiretroviral therapy (ART) retention across health facilities among pregnant and lactating women and assess for differences in ART retention between Option B+ clients and other ART patients. RESULTS: There were 1989 Option B+ clients who initiated ART in 45 health facilities...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29781346/distribution-characteristics-of-cells-in-splenomegaly-due-to-hepatitis-b-related-cirrhotic-portal-hypertension-and-their-clinical-importance
#19
Xiaoyu Han, Yunfu Lv, Yejuan Li, Jie Deng, Qingan Qiu, Ning Liu, Shuya Zhao, Caixian Liao
Objectives To investigate peripheral cytopenia in patients with splenomegaly due to hepatitis B-related cirrhotic portal hypertension (HBRCPH) by comparing blood cell counts from enlarged spleens with peripheral blood. Methods This prospective study involved patients undergoing splenectomy at the Nangfang Hospital from June 2013 to December 2015. Blood cell counts from peripheral blood were compared with those from splenic blood taken during splenectomies. Results Clinical data were available from 30 patients...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29781209/oral-phase-dysphagia-in-facial-onset-sensory-and-motor-neuronopathy
#20
Mitsuru Watanabe, Wataru Shiraishi, Ryo Yamasaki, Noriko Isobe, Motohiro Sawatsubashi, Ryuji Yasumatsu, Takashi Nakagawa, Jun-Ichi Kira
INTRODUCTION: Facial onset motor and sensory neuronopathy (FOSMN) is a rare disease whose cardinal features are initial asymmetrical facial sensory deficits followed by bulbar symptoms and spreading of sensory and motor deficits from face to scalp, neck, upper trunk, and upper extremities in a rostral-caudal direction. Although bulbar involvement is frequently observed in FOSMN, dysphagia in these patients has not been fully described. In this study, we aimed to characterize dysphagia as a prognostic factor in FOSMN by investigating our institutional case series...
May 21, 2018: Brain and Behavior
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