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https://www.readbyqxmd.com/read/29166723/-association-between-serum-n%C3%AE%C2%B5-carboxymethyl-lysine-level-and-anterior-tibial-arterial-plaque-calcification-in-patients-with-diabetic-foot-post-foot-amputation
#1
L H Li, F Ye, X L Fu, S N Xu, Z Y Bao, Z Sun, J C Yan, J N Wu, Z Q Wang
Objective: To observe the correlation between Nε-carboxymethyl-Lysine (CML), the main component of advanced glycation end products and the calcification of the anterior tibial artery plaque in patients with diabetic foot post foot amputation. Methods: Sixty patients hospitalized for foot amputation operation due to diabetic foot from June 2012 to June 2016 in the Department of Orthopedics, Affiliated Hospital of Jiangsu University were prospectively recruited.The patients were categorized into mild stenosis (0<stenosis<50%, n=20), moderate stenosis (50%≤stenosis<70%, n=20) and severe stenosis (70%≤stenosis≤100%, n=20) based on the color Doppler ultrasound assessed severity of anterior tibial artery stenosis...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166423/exhaled-and-nasal-nitric-oxide-in-chronic-rhinosinusitis-patients-with-nasal-polyps-in-primary-care
#2
M Frendo, K Hakansson, S Schwer, A T Ravn, H Meteran, C Porsbjerg, V Backer, C von Buchwald
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder associated with lower airway disease. However, only few studies of CRSwNP from outside secondary/tertiary care centres have been published. We recently reported an asthma frequency of 44% and 65% in primary and secondary care patients respectively. Therefore, we hypothesise that inflammation of the lower airways could be present in all CRSwNP patients, even without asthma. Here, we assessed the degree of lower and upper airway inflammation using exhaled and nasal nitric oxide (NO) in primary care CRSwNP patients with and without asthma...
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29166299/exercise-and-the-tumor-microenvironment-potential-therapeutic-implications
#3
Jennifer M Wiggins, Alexander B Opoku-Acheampong, Dryden R Baumfalk, Dietmar W Siemann, Bradley J Behnke
An imbalance in oxygen delivery-to-demand in solid tumors results in local areas of hypoxia leading to poor patient prognosis. We hypothesize that aerobic exercise increases tumor blood flow, recruits previously non-perfused tumor blood vessels and thereby augments blood-tumor O2 transport and diminishes tumor hypoxia. When combined with conventional anti-cancer treatments, aerobic exercise can significantly improve the outcomes for several types of cancers.
November 21, 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29165895/adaptation-and-validation-of-the-turkish-version-of-the-nasal-obstruction-symptom-evaluation-scale
#4
Ozlem Onerci Celebi, Ela Araz Server, Ozgur Yigit, Ecem Sevim Longur
BACKGROUND: The Nasal Obstruction Symptom Evaluation (NOSE) scale is a questionnaire used to assess the quality of life in patients with nasal obstruction. The aim of this study was to validate the Turkish translation of the NOSE questionnaire. METHODS: The NOSE questionnaire was translated into Turkish and then back to English. Fifty patients with septal deviation leading to nasal obstruction and 50 healthy subjects without any nasal complaints and pathologies were recruited into the study...
November 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29165788/factors-affecting-compliance-with-confirmatory-colonoscopy-after-a-positive-fecal-immunochemical-test-in-a-national-colorectal-screening-program
#5
Shao-Yi Cheng, Ming-Chieh Li, Shu-Li Chia, Kuo-Chin Huang, Tai-Yuan Chiu, Ding-Cheng Chan, Han-Mo Chiu
BACKGROUND: Screening with the fecal immunochemical test (FIT) is effective in reducing deaths from colorectal cancer (CRC). Since 2004, biennial FIT screening has been available to a target population in Taiwan as a national screening program. The objective of the current study was to identify the factors that influence willingness to undergo a confirmatory colonoscopy after a positive FIT, because related references in the published literature were scarce. METHODS: A semistructured questionnaire was based on the Health Belief Model (HBM) and a literature review...
November 22, 2017: Cancer
https://www.readbyqxmd.com/read/29165642/the-corticospinal-reserve-capacity-reorganization-of-motor-area-and-excitability-as-a-novel-pathophysiological-concept-in-cervical-myelopathy
#6
Anna Zdunczyk, Vera Schwarzer, Michael Mikhailov, Brendon Bagley, Tizian Rosenstock, Thomas Picht, Peter Vajkoczy
BACKGROUND: In degenerative cervical myelopathy (DCM), the dynamics of disease progression and the outcome after surgical decompression vary interindividually and do not necessarily correlate with radiological findings. OBJECTIVE: To improve diagnostic power in DCM by better characterization of the underlying pathophysiology using navigated transcranial magnetic stimulation (nTMS). METHODS: Eighteen patients with DCM due to cervical spinal canal stenosis were examined preoperatively with nTMS...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29165577/quantitative-mri-brain-in-congenital-adrenal-hyperplasia-in-vivo-assessment-of-the-cognitive-and-structural-impact-of-steroid-hormones
#7
Emma A Webb, Lucy Elliott, Dominic Carlin, Martin Wilson, Kirsty Hall, Jennifer Netherton, Julie Reed, Tim G Barrett, Vijay Salwani, Jon D Clayden, Wiebke Arlt, Nils Krone, Andrew C Peet, Amanda G Wood
Context: Brain white matter hyper-intensities are seen on routine clinical imaging in 46% of adults with congenital adrenal hyperplasia (CAH). The extent and functional relevance of these abnormalities have not been studied using quantitative MRI analysis. Objective: To examine white matter microstructure, neural volumes and CNS metabolites in CAH due to 21-hydroxylase deficiency (21OHD) and to determine whether identified abnormalities are associated with cognition, glucocorticoid and androgen exposure...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165145/organochlorine-pesticide-level-in-patients-with-chronic-kidney-disease-of-unknown-etiology-and-its-association-with-renal-function
#8
Rishila Ghosh, Manushi Siddarth, Neeru Singh, Vipin Tyagi, Pawan Kumar Kare, Basu Dev Banerjee, Om Prakash Kalra, Ashok Kumar Tripathi
BACKGROUND: Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study. METHODS: All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100)...
May 26, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165136/genetic-analysis-of-rnf213-p-r4810k-variant-in-non-moyamoya-intracranial-artery-stenosis-occlusion-disease-in-a-chinese-population
#9
Tong Zhang, Congrong Guo, Xin Liao, Jian Xia, XiaoXiao Wang, Jing Deng, Junxia Yan
OBJECTIVES: RNF213 p.R4810K was identified as a susceptibility variant for moyamoya disease in Asia and non-moyamoya intracranial artery stenosis/occlusion disease in Japan and Korea recently. The occurrence of this variant was evaluated in patients with non-moyamoya intracranial artery stenosis/occlusion disease in China. METHODS: Two study populations were used in this study. One was recruited from the Second Hospital of Hebei Medical University from April 2015 to May 2016...
April 24, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165097/a-predictive-model-of-the-prevalence-of-delirium-in-elderly-subjects-admitted-to-nursing-homes
#10
Pilar Perez-Ros, Francisco Miguel Martinez-Arnau, Susana Baixauli-Alacreu, Jose Fermin Garcia-Gollarte, Francisco Tarazona-Santabalbina
INTRODUCTION: Delirium is common in geriatric patients admitted to nursing homes, with an incidence of 22-79% among long-term residents. AIM: To establish a predictive model of the risk of delirium episodes in a sample of elderly people living in nursing homes. MATERIAL AND METHODS: A retrospective, cross-sectional case-control study covering a period of 12 consecutive months (April 2014 - March 2015) was carried out. The included cases had suffered at least one episode of delirium during the study period...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165094/potential-risks-and-mitigation-strategies-during-the-conduct-of-a-clinical-trial-an-industry-perspective
#11
Seema Bhagat, Vaibhavi Kapatkar, Sagar Katare, Ashish Mane, Colette Pinto, Kedar Pawar, Agam Shah, Hanmant Barkate
BACKGROUND: Every phase of a clinical trial should be designed in compliance with good clinical practices by following all relevant regulatory guidelines. Patient safety, data integrity and ethics are an integral part of a successful clinical trial which must be considered. Therefore risk monitoring is an essential tool to identify the risks associated with conduct of any trial. This article is a result of extensive research conducted by a reputed pharmaceutical company to identify the potential stages of risks associated with the conduct phase of trial that could impact the overall quality and safety of a trial...
November 19, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29165083/subjective-spatial-navigation-complaints-a-frequent-symptom-reported-by-patients-with-subjective-cognitive-decline-mild-cognitive-impairment-and-alzheimer-s-disease
#12
Cerman Jiri, Andel Ross, Laczo Jan, Vyhnalek Martin, Nedelska Zuzana, Mokrisova Ivana, Sheardova Katerina, Hort Jakub
BACKGROUND: Great effort has been put into developing simple and feasible tools capable to detect Alzheimer's disease (AD) in its early clinical stage. Spatial navigation impairment occurs very early in AD and is detectable even in the stage of mild cognitive impairment (MCI). OBJECTIVE: The aim was to describe the frequency of self-reported spatial navigation complaints in patients with subjective cognitive decline (SCD), amnestic and non-amnestic MCI (aMCI, naMCI) and AD dementia and to assess whether a simple questionnaire based on these complaints may be used to detect early AD...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29165026/comparative-evaluation-of-oral-and-dento-maxillofacial-manifestation-of-patients-with-sickle-cell-diseases-and-beta-thalassemia-major
#13
Salmeh Kalbassi, Mohammad Reza Younesi, Vahid Asgary
BACKGROUND: Regarding the importance of oral and dental health in patients with hemoglobinopathies and also due to the different results of different studies in this background, in patients with beta thalassemia (BTM) and sickle cell disease (SCD), this study aimed to evaluate and compare the oral and dental manifestations of patients with BTM and SCD. MATERIAL AND METHODS: In this cross-sectional study during the years 2014-2017, a total of 175 patients (with documented BTM or SCD attending to Tehran, Mashhad, Isfahan, and Tabriz cities central hospitals) were randomly recruited...
November 22, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29164957/expectations-concerns-and-needs-of-patients-who-start-drugs-for-chronic-conditions-a-prospective-observational-study-among-community-pharmacies-in-serbia
#14
Katarina M Vučićević, Branislava R Miljković, Bojana C Golubović, Marija N Jovanović, Sandra D Vezmar Kovačević, Milica D Ćulafić, Milena M Kovačević, Johan J de Gier
BACKGROUND: During the initiation of treatment of a chronic disease, patients may have varying interests, expectations, concerns, and reasons to stop treatment, influencing compliance with prescribed treatment. Thus, healthcare professionals are expected to integrate these needs into medicines management. OBJECTIVES: To determine what information is important to patients; assess predictors of patients' interests, expectations, concerns, reasons to stop therapy; evaluate drug-related problems following initiation of therapy and summarize how pharmacists resolve them during patient-pharmacist counselling...
November 22, 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29164923/impact-of-traditional-versus-flavored-tongue-depressors-on-pediatric-oropharynx-exam
#15
Brian Murray, Marina Gore, Nicole R Leonard, Nadia M Pearson, Jeremiah J Johnson, Michael D April
We compared patient-reported discomfort associated with oropharynx examination using traditional (unflavored) versus flavored tongue depressors among pediatric patients presenting to the emergency department in a single-blinded, placebo-controlled randomized trial using a convenience sample ages 3 to 12 years. Our primary outcome was patient discomfort. Secondary outcomes included provider perceptions of patient discomfort, provider-reported examination ease, and caregiver perceptions of patient discomfort...
November 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29164920/cardiac-structure-and-function-predicts-functional-decline-in-the-oldest-old
#16
David Leibowitz, Jeremy M Jacobs, Irit Lande-Stessman, Dan Gilon, Jochanan Stessman
Background This study examined the association between cardiac structure and function and the deterioration in activities of daily living (ADLs) in an age-homogenous, community-dwelling population of patients born in 1920-1921 over a five-year follow-up period. Design Longitudinal cohort study. Methods Patients were recruited from the Jerusalem Longitudinal Cohort Study, which has followed an age-homogenous cohort of Jerusalem residents born in 1920-1921. Patients underwent home echocardiography and were followed up for five years...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29164837/serum-surfactant-protein-d-and-exhaled-nitric-oxide-as-biomarkers-of-early-lung-damage-in-systemic-sclerosis
#17
Alida Benfante, Riccardo Messina, Alessandra Paternò, Nicola Scichilone
BACKGROUND: Interstitial lung disease (ILD) complicates the course of systemic sclerosis (SSc), representing the main cause of death in these patients. The identification of parameters that can predict the early onset and progression of ILD in SSc represents an unmet need in clinical practice. The study was designed to explore whether the surfactant proteins (SP) A and D may be used as noninvasive tools for the early identification of ILD in SSc. Alveolar exhaled nitric oxide (NO) was investigated as a surrogate marker of distal inflammation...
November 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29164743/patient-initiated-recruitment-for-clinical-research-evaluation-of-an-outpatient-letter-research-statement
#18
Matthias Wienroth, Louise Caffrey, Charles Wolfe, Christopher McKevitt
BACKGROUND: UK Hospital Trusts are charged with increasing patients' research awareness and willingness to take part in research. This includes implementing strategies to encourage patient-initiated enquiries about participation. OBJECTIVES: To evaluate the impact of a research statement inserted in outpatient letters in one clinical service, and to derive suggestions on potential steps towards increasing patient-initiated recruitment. SETTING: A medical outpatient clinic of a research-active hospital trust, serving an inner-city multi-ethnic population across two boroughs...
November 22, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29164621/determining-candidate-single-nucleotide-polymorphisms-in-acquired-laryngotracheal-stenosis
#19
Mursalin M Anis, Natalia Krynetskaia, Zhigen Zhao, Evgeny Krynetskiy, Ahmed M S Soliman
OBJECTIVES/HYPOTHESIS: Despite wide adoption of strategies to prevent injury from prolonged intubation and tracheotomy, acquired laryngotracheal stenosis (ALTS) has not disappeared. ALTS' persistence may be due to patient factors that confer unique susceptibility for some. We sought to identify genetic markers in genes associated with wound healing that could be associated with ALTS. STUDY DESIGN: Case-control study. METHODS: One hundred thirty-eight patients were recruited, 53 patients with ALTS and 85 control patients who underwent intubation or tracheotomy without evidence of ALTS...
November 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29164585/expression-and-clinical-significance-of-mir-181a-and-mir-203-in-systemic-lupus-erythematosus-patients
#20
H-S Li, Y Ning, S-B Li, P-Y Shao, S-J Chen, Q Ye, X Heng
OBJECTIVE: MiR-181a plays a critical role in modulating T cell and B cell differentiation, as well as immune response. Its abnormal expression probably participates in the pathogenesis of systemic lupus erythematosus (SLE). MiR-203 is involved in regulating Toll-like receptor and inducing immune tolerance. Abnormal expression or function of miR-203 is related to multiple auto-immune diseases but its role in SLE remains unclear. This study, thus, investigated the serum level of miR-181a and miR-203, to analyze their roles in diagnosing and evaluating SLE...
November 2017: European Review for Medical and Pharmacological Sciences
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