keyword
https://read.qxmd.com/read/38547428/eosinophil-expression-of-triggering-receptor-expressed-on-myeloid-cells-1-trem-1-restricts-type-2-lung-inflammation
#1
JOURNAL ARTICLE
Jayden L Bowen, Kathy Keck, Sankar Baruah, Kathy H Nguyen, Andrew L Thurman, Alejandro A Pezzulo, Julia Klesney-Tait
Asthma affects 25 million Americans and recent advances in treatment are effective for only a portion of severe asthma patients. Triggering Receptor Expressed on Myeloid cells 1 (TREM-1), an innate receptor that canonically amplifies inflammatory signaling in neutrophils and monocytes, plays a central role in regulating lung inflammation. It is unknown how TREM-1 contributes to allergic asthma pathology. Utilizing a murine model of asthma, flow cytometry revealed TREM-1+ eosinophils in the lung tissue and airway during allergic airway inflammation...
March 28, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38547058/nsun5-tet2-directed-chromatin-associated-rna-modification-of-5-methylcytosine-to-5-hydroxymethylcytosine-governs-glioma-immune-evasion
#2
JOURNAL ARTICLE
Ruixin Wu, Chunming Sun, Xi Chen, Runyue Yang, Yuxuan Luan, Xiang Zhao, Panpan Yu, Rongkui Luo, Yingyong Hou, Ruotong Tian, Shasha Bian, Yuli Li, Yinghua Dong, Qian Liu, Weiwei Dai, Zhuoyang Fan, Rucheng Yan, Binyang Pan, Siheng Feng, Jing Wu, Fangzhen Chen, Changle Yang, Hanlin Wang, Haochen Dai, Minfeng Shu
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C-modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down-regulates β-catenin by promoting the degradation of its mRNA, leading to enhanced phagocytosis of tumor-associated macrophages (TAMs)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38546777/are-patients-with-type-2-diabetes-in-the-waikato-district-provided-with-adequate-education-and-support-in-primary-care-to-self-manage-their-condition-a-qualitative-study
#3
JOURNAL ARTICLE
Rebekah Crosswell, Kimberley Norman, Shemana Cassim, Valentina Papa, Rawiri Keenan, Ryan Paul, Lynne Chepulis
Introduction In Aotearoa New Zealand (NZ), type 2 diabetes (T2D) is predominantly managed in primary care. Despite established guidelines, patients are often suboptimally managed, with inequitable health outcomes. To date, few NZ studies have evaluated the primary care management of T2D at the time of diagnosis. Aim This study aims to explore patients' the provision of education and delivery of care to patients at the time of diagnosis, which is a crucial time in the disease trajectory. Methods Participants were recruited from a Māori health provider in the Waikato District, and diagnosed with T2D after January 2020...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546766/-i-think-we-just-do-it-once-and-leave-it-%C3%A2-the-collection-and-utility-of-family-health-history-in-general-practice-in-aotearoa-new-zealand-a-qualitative-study
#4
JOURNAL ARTICLE
R Jefferies, P Wilcox, K Paringatai, M Stubbe, R Grainger, A Dowell, S K Filoche
Introduction The value of family health history as a means to understanding health risk has been long known. Its value in a precision medicine context is also now becoming apparent. General practitioners (GPs) are considered to play a key role in the collection, and investigation, of family health history, but it remains widely reported as being both poorly and infrequently undertaken. Little is known about this practice in Aotearoa New Zealand (NZ). Aim This study aimed to explore current practices in relation to the ascertainment of family health history, with a view towards precision medicine...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546756/the-impact-of-demodex-blepharitis-on-patient-symptoms-and-daily-life
#5
JOURNAL ARTICLE
Melissa Barnett, Blake Simmons, Patrick Vollmer, Assem Patel, William E Whitson, Gregg J Berdy, Paul Karpecki, Laura M Periman, Mark Holdbrook, Stephanie N Baba, John Meyer, Elizabeth Yeu
SIGNIFICANCE: Patients with Demodex blepharitis have a considerable symptomatic burden that negatively impacts their daily activities and well-being. Despite chronic manifestations of and problems associated with blepharitis that resulted in multiple visits to eye care providers, Demodex blepharitis remained underdiagnosed or misdiagnosed. PURPOSE: This study aimed to evaluate the effect of Demodex blepharitis on patients' daily activities and well-being. METHODS: This prospective, multicenter, observational study recruited 524 patients with Demodex blepharitis from 20 U...
March 1, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://read.qxmd.com/read/38546733/high-flow-humidified-oxygen-as-an-early-intervention-in-children-with-acute-severe-asthma-protocol-for-a-feasibility-randomized-controlled-trial
#6
JOURNAL ARTICLE
Hector Rojas-Anaya, Akshat Kapur, Graham Roberts, Damian Roland, Atul Gupta, Michaela Lazner, Jane Bayreuther, John Pappachan, Christina Jones, Stephen Bremner, Fleur Cantle, Paul Seddon
BACKGROUND: Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail to respond to first-line therapy is problematic: the use of intravenous agents is inconsistent, and side effects are frequent. High-flow humidified oxygen (HiFlo) is widely used in respiratory conditions and is increasingly being used in ASA, but with little evidence for its effectiveness...
March 28, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38546395/screen11-validating-a-screening-instrument-for-voice-disorders-in-accordance-with-the-cosmin-framework
#7
JOURNAL ARTICLE
Sofia Holmqvist-Jämsén, Daniel Fellman, Greta Öhlund Wistbacka, Jonna Kuuskoski, Miia Ruuskanen, Alma Zenger, Jemima Rantanen, Susanna Simberg
PURPOSE: Although numerous patient-reported outcome measures have been developed and validated to quantify the impact of voice problems on different aspects of life, to our knowledge no screening instrument exists that specifically captures voice disorders in a retrospective fashion. The aim of the present study was to examine the psychometric properties and diagnostic validity of a retrospective voice screening method, Screen11, according to the COSMIN framework for health-related, patient-reported outcome measures...
March 28, 2024: Logopedics, Phoniatrics, Vocology
https://read.qxmd.com/read/38546244/assessment-of-treatment-outcomes-in-the-management-of-club-foot-using-the-ponseti-technique-a-cross-sectional-study
#8
JOURNAL ARTICLE
Joseph E Asuquo, Enembe O Okokon, Omolade Ayoola Lasebikan, Chukwuemeka Okechukwu Anisi, Best J Asuquo, Innocent Egbeji Abang, Akpet E Obaji, Kingsley C Chigbundu
BACKGROUND: The Ponseti technique remains the preferred method for club foot treatment. Although measures of treatment outcomes have been well documented, there is no consensus on the determinants of those outcomes. This study aims to assess treatment outcomes and the factors which can influence treatment outcomes. MATERIALS AND METHODS: This is a cross-sectional study. A total of 472 children representing 748 feet in total were recruited. Patient characteristics such as age at presentation, gender, tenotomy, walking with or without deformity, parental educational status and occupation were documented...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38546160/developmental-and-behavioral-phenotypes-of-pediatric-patients-with-pten-hamartoma-tumor-syndrome
#9
JOURNAL ARTICLE
Suzanne P MacFarland, Melani Duvall, Raissa Tchetcho Kemajou, Sarah E Baldino, Kristin Zelley, Chelsea Black, Allison Thomas, Nina H Thomas, Melanie Ruffner, Yimei Li, Judith S Miller, Garrett M Brodeur, Emily Shabason
Our study characterized the neurodevelopmental spectrum of individuals with PTEN Hamartoma Tumor Syndrome (PHTS), a syndrome that predisposes to both neurodevelopmental phenotypes and cancer risk. We aim to better understand life-impacting neurodevelopmental features of PHTS. Our study recruited 20 children/adolescents with PHTS, who were then administered assessments for autism spectrum disorder (ASD) and other neurocognitive measures, including assessment of IQ, executive and adaptive functioning, and health-related quality of life...
March 28, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38546082/health-literacy-and-demand-for-medical-cannabis-use-among-colorectal-cancer-patients-in-northern-thailand-a-cross-sectional-study
#10
JOURNAL ARTICLE
Alongkorn Sukrueangkul, Petcherut Sirisuwan, Kanlayawee Anonjarn, Punrada Poungsamai, Suchitra Hudrudchai, Napapat Thongkamwong, Poramate Insook, Patitta Suangpho
OBJECTIVE: This study aimed to explore health literacy and factors associated with demand for medical cannabis (MC) use among colorectal cancer (CRC) patients in Northern Thailand as a target group. METHODS: This cross-sectional analytical study administered multistage random sampling to recruit 439 CRC patients in northern Thailand. Ethical approval and signed written informed consents were obtained from the patients, prior to the study. A standardized, self-administered structured questionnaire was used to obtain the sociodemographic characteristics, clinical characteristics, social support, attitudes toward MC, knowledge about MC, health literacy about MC, and questions on demand for MC use...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38545883/exploring-information-seeking-anxiety-among-localized-prostate-cancer-patients
#11
JOURNAL ARTICLE
Levi Ross, Michael A Preston, Torhonda C Lee, Jala Lockhart, Jordan Young, Angela Wood, Ralph Wood
Information seeking anxiety is a multidimensional construct that is operationalized as having elements of worry, confusion, and disorganization. Much remains unknown about the ways information seeking anxiety operates among cancer patients in the United States. This study investigated the application of the information seeking anxiety concept among prostate cancer patients by documenting their assessment experiences and examining relationships between information seeking anxiety and treatment information search behaviors...
2024: American Journal of Men's Health
https://read.qxmd.com/read/38545711/-not-available
#12
JOURNAL ARTICLE
Nouha Ammar, Faten Ezzairi, Nihel Omri, Asma Ammar, Olfa Ezzi, Tessnim Ben El Ghali, Mouhamed Mahjoub, Imene Chabchoub, Slim Ben Ahmed, Mansour Njah
INTRODUCTION AND AIM: To assess physical activity (PA) and its determinants in breast cancer survivors (BCS), attending a Tunisian hospital, as well as to assess their quality of life (QOL) and examine the relationship between PA and BCS'QOL. METHODS: We conducted a cross-sectional study among BCS attending the outpatient oncology, gynecology and radiotherapy clinics at a Tunisian hospital in April 2022 using a self-administered questionnaire. The valid Arabic version of the International Physical Activity...
March 5, 2024: La Tunisie Médicale
https://read.qxmd.com/read/38545602/long-term-effects-of-mobile-exoneuromusculoskeleton-enms-assisted-self-help-telerehabilitation-after-stroke
#13
JOURNAL ARTICLE
Wanyi Qing, Ching-Yi Nam, Harvey Man-Hok Shum, Marko Ka-Leung Chan, King-Pong Yu, Serena Sin-Wah Ng, Bibo Yang, Xiaoling Hu
Investigation on long-term effects of robot-assisted poststroke rehabilitation is challenging because of the difficulties in administration and follow-up of individuals throughout the process. A mobile hybrid neuromuscular electrical stimulation (NMES)-robot, i.e., exoneuromusculoskeleton (ENSM) was adopted for a single-group trial to investigate the long-term effects of the robot-assisted self-help telerehabilitation on upper limb motor function after stroke. Twenty-two patients with chronic stroke were recruited to attend a 20-session telerehabilitation program assisted by the wrist/hand module of the ENMS (WH-ENMS)...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38545519/a-multisite-longitudinal-investigation-of-psychological-outcomes-following-cataract-surgery-in-india
#14
JOURNAL ARTICLE
S G Prem Kumar, Pankaj Vishwakarma, Dhanaji Ranpise, Shobhana Chavan, Radhika Krishnan, Elizabeth Kurian, Team Mfv Mental Health Study
BACKGROUND: Systematic data on mental health issues among adults with cataracts are not available from India. This study explored the impact of cataract surgery on depressive and generalized anxiety (GA) symptoms in an adult Indian sample. METHODS: A multicenter, prospective, longitudinal cohort study was conducted. Subjects were recruited from four tertiary eye hospitals to assess depression, GA, and associated risk factors. A follow-up survey was carried out at 6 ( n = 273, group 1), 12 ( n = 198, group 2), or 18 months ( n = 105, group 3) post-cataract surgery...
November 2023: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/38545497/-i-felt-part-of-the-solution-a-qualitative-study-about-the-interface-between-lived-experience-advocates-professionals-and-organisations-in-the-field-of-persistent-pain
#15
JOURNAL ARTICLE
Cameron Hartley, Chris Penlington
OBJECTIVES: To elicit perspectives of people with persistent pain about their experiences working with pain management professionals and services as patient advocates and to consider implications for current models of involving patients in service development and research. DESIGN: reflexive thematic analysis from a critical realist perspective. METHODS: Online interviews were conducted individually with 10 participants who had acted as patient advocates in the field of persistent pain...
April 2024: British Journal of Pain
https://read.qxmd.com/read/38545496/-virtualpain-preliminary-findings-from-a-group-based-digital-therapeutics-intervention-for-fibromyalgia
#16
JOURNAL ARTICLE
Ferran Vilalta-Abella, Bruno Porras-Garcia, Alexandra Ghiţă, Montserrat Vacas-Moreira, Mónica Prat-Galbany, José Gutiérrez-Maldonado
INTRODUCTION: Fibromyalgia (FM) is a disorder characterized by chronic pain, with significant medical, psychological, and socio-economic implications. Although there is limited evidence, cognitive-behavioral therapy (CBT) has shown to be effective in improving FM symptoms. An alternative to enhance CBT effectiveness is to incorporate digital therapeutics (DTx). AIM: We conducted a pilot study to investigate whether the addition of a DTx intervention ( VirtualPain ) to cognitive-behavioral group therapy (CBGT) can reduce pain perception and associated symptoms in patients with FM...
April 2024: British Journal of Pain
https://read.qxmd.com/read/38545336/teleyoga-for-patients-with-alzheimer-s-disease-and-chronic-musculoskeletal-pain-and-their-caregivers-a-feasibility-study
#17
JOURNAL ARTICLE
Santiago Allende, Louise Mahoney, Jasmin M Francisco, Korrine Fitz, Audrey Keaney, Kelly Parker-Bridges, Heidi Mahoney, Booil Jo, Jason Greenberg, Peter J Bayley
BACKGROUND: Chronic musculoskeletal pain is common in patients with Alzheimer's disease (AD), and there is growing awareness that chronic pain has an impact on the progression of dementia. Yoga has shown promise in treating chronic pain. However, attending in-person yoga can be difficult for AD patients. OBJECTIVE: To assess the feasibility, acceptability and preliminary efficacy of an online yoga (teleyoga) protocol suitable for AD patients with chronic pain, and their caregivers...
2024: Glob Adv Integr Med Health
https://read.qxmd.com/read/38545316/the-readiness-of-saudi-nursing-interns-for-the-professional-role
#18
JOURNAL ARTICLE
Marym M Alaamri, Abeer A Alasmari, Jelan A Alasiri, Reem A Bahaddad, Atheer K Alsulami, Rawan M H AlQarni, Aisha Alhofaian, Afnan Tunsi
BACKGROUND: The nursing education program offers opportunities to prepare nursing students with the knowledge and skills required for their professional roles. The level of their readiness and confidence will affect their ability to provide effective and sufficient nursing care. The purpose of this study is to assess nursing interns readiness for professional roles. MATERIALS AND METHOD: To accomplish the study's objectives, a cross-sectional, descriptive design was employed...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38545116/hbsag-level-defines-different-clinical-phenotypes-of-hbeag-chronic-hbv-infection-related-to-hbv-polymerase-specific-cd8-cell-response-quality
#19
JOURNAL ARTICLE
Julia Peña-Asensio, Henar Calvo-Sánchez, Joaquín Miquel-Plaza, Eduardo Sanz-de-Villalobos, Alejandro González-Praetorius, Alberto Delgado-Fernandez, Miguel Torralba, Juan-Ramón Larrubia
BACKGROUND: HBe-antigen(Ag)-negative chronic hepatitis B virus (HBV) infection is characterized by little liver fibrosis progression and vigorous HBV-multispecific CD8+ T-cell response. AIMS: To assess whether HBsAg level could discriminate different HBeAg-negative chronic HBV infection subtypes with dissimilar quality of HBV-specific CD8+ T-cell response. METHODS: We recruited 63 HBeAg-negative chronic HBV infection patients in which indirect markers of liver inflammation/fibrosis, portal pressure, viral load (VL), and HBV-specific CD8+ cell effector function were correlated with HBsAg level...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545090/efficacy-of-oral-20-hydroxyecdysone-bio101-a-mas-receptor-activator-in-adults-with-severe-covid-19-cova-a%C3%A2-randomized-placebo-controlled-phase-2-3-trial
#20
JOURNAL ARTICLE
Suzana Margareth Lobo, Gaétan Plantefève, Girish Nair, Adilson Joaquim Cavalcante, Nara Franzin de Moraes, Estevao Nunes, Otis Barnum, Claudio Marcel Berdun Stadnik, Maria Patelli Lima, Muriel Lins, Ludhmila Abrahao Hajjar, Christopher Lipinski, Shaheen Islam, Fabiano Ramos, Tiago Simon, Jean-Benoît Martinot, Thomas Guimard, Arnaud Desclaux, Bertrand Lioger, Fernando Carvalho Neuenschwander, Bruno DeSouza Paolino, Alpesh Amin, Samuel Amil Acosta, Daniel Forde Dilling, Edgardo Cartagena, Brian Snyder, Edouard Devaud, Ana Karolina Barreto Berselli Marinho, Suzana Tanni, Patricia Medeiros Milhomem Beato, Stephan De Wit, Vani Selvan, Jeffrey Gray, Ricardo Fernandez, Valérie Pourcher, Lee Maddox, Richard Kay, Anait Azbekyan, Mounia Chabane, Cendrine Tourette, Luis Everton Esmeraldino, Pierre J Dilda, René Lafont, Jean Mariani, Serge Camelo, Sandrine Rabut, Samuel Agus, Stanislas Veillet, Waly Dioh, Rob van Maanen, Capucine Morelot-Panzini
BACKGROUND: SARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due to COVID-19. The aim of the study was to test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore the Renin-Angiotensin System equilibrium and limit the frequency of respiratory failure and mortality in adults hospitalized with severe COVID-19. METHODS: Double-blind, randomized, placebo-controlled phase 2/3 trial. Randomization: 1:1 oral BIO101 (350 mg BID) or placebo, up to 28 days or until an endpoint was reached...
February 2024: EClinicalMedicine
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