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lactoferrin, bdnf

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https://www.readbyqxmd.com/read/27763700/early-life-diets-with-prebiotics-and-bioactive-milk-fractions-attenuate-the-impact-of-stress-on-learned-helplessness-behaviours-and-alter-gene-expression-within-neural-circuits-important-for-stress-resistance
#1
Agnieszka Mika, Heidi E W Day, Alexander Martinez, Nicole L Rumian, Benjamin N Greenwood, Maciej Chichlowski, Brian M Berg, Monika Fleshner
Manipulating gut microbes may improve mental health. Prebiotics are indigestible compounds that increase the growth and activity of health-promoting microorganisms, yet few studies have examined how prebiotics affect CNS function. Using an acute inescapable stressor known to produce learned helplessness behaviours such as failure to escape and exaggerated fear, we tested whether early life supplementation of a blend of two prebiotics, galactooligosaccharide (GOS) and polydextrose (PDX), and the glycoprotein lactoferrin (LAC) would attenuate behavioural and biological responses to stress later in life...
October 20, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/25146846/lactoferrin-promotes-early-neurodevelopment-and-cognition-in-postnatal-piglets-by-upregulating-the-bdnf-signaling-pathway-and-polysialylation
#2
Yue Chen, Zhiqiang Zheng, Xi Zhu, Yujie Shi, Dandan Tian, Fengjuan Zhao, Ni Liu, Petra S Hüppi, Frederic A Troy, Bing Wang
Lactoferrin (Lf) is a sialic acid (Sia)-rich, iron-binding milk glycoprotein that has multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. To test the hypothesis that Lf may function to improve neurodevelopment and cognition, the diet of postnatal piglets was supplemented with Lf from days 3 to 38. Expression levels of selected genes and their cognate protein profiles were quantitatively determined. The importance of our new findings is that Lf (1) upregulated several canonical signaling pathways associated with neurodevelopment and cognition; (2) influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway in the hippocampus and upregulated the expression of polysialic acid, a marker of neuroplasticity, cell migration and differentiation of progenitor cells, and the growth and targeting of axons; (3) upregulated transcriptional and translational levels of BDNF and increased phosphorylation of the cyclic adenosine monophosphate (cAMP) response element-binding protein, CREB, a downstream target of the BDNF signaling pathway, and a protein of crucial importance in neurodevelopment and cognition; and (4) enhanced the cognitive function and learning of piglets when tested in an eight-arm radial maze...
August 2015: Molecular Neurobiology
https://www.readbyqxmd.com/read/24824862/lactoferrin-up-regulates-intestinal-gene-expression-of-brain-derived-neurotrophic-factors-bdnf-uchl1-and-alkaline-phosphatase-activity-to-alleviate-early-weaning-diarrhea-in-postnatal-piglets
#3
Changwei Yang, Xi Zhu, Ni Liu, Yue Chen, Hexia Gan, Frederic A Troy, Bing Wang
The molecular mechanisms underlying how dietary lactoferrin (Lf) impacts gut development and maturation and protects against early weaning diarrhea are not well understood. In this study, we supplemented postnatal piglets with an Lf at a dose level of 155 and 285 mg/kg/day from 3 to 38 days following birth. Our findings show that the high dose of Lf up-regulated messenger RNA expression levels of genes encoding brain-derived neurotrophic factor (BDNF) and ubiquitin carboxy-terminal hydrolase L1 (ubiquitin thiolesterase (UCHL1) and, to a lesser extent, glial cell line-derived neurotrophic factor, in the duodenum (P<...
August 2014: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/24213624/protective-effects-of-maternal-nutritional-supplementation-with-lactoferrin-on-growth-and-brain-metabolism
#4
Emmanuel Somm, Pierre Larvaron, Yohan van de Looij, Audrey Toulotte, Alexandra Chatagner, Magali Faure, Sylviane Métairon, Robert Mansourian, Frédéric Raymond, Rolf Gruetter, Bing Wang, Stéphane V Sizonenko, Petra S Hüppi
BACKGROUND: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown. METHODS: IUGR was induced through maternal dexamethasone infusion (100 μg/kg during last gestational week) in rats...
January 2014: Pediatric Research
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