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https://www.readbyqxmd.com/read/28647501/driving-simulators-in-the-clinical-assessment-of-fitness-to-drive-in-sleepy-individuals-a-systematic-review
#1
REVIEW
David R Schreier, Christina Banks, Johannes Mathis
Road traffic injuries are projected to be the leading cause of death for those aged between 15 and 29 years by the year 2030, and sleepiness is estimated to be the underlying cause in up to 15-20% of all motor vehicle accidents. Sleepiness at the wheel is most often caused by socially induced sleep deprivation or poor sleep hygiene in otherwise healthy individuals, medical disorders, or the intake of drugs. Validated methods for objectifying sleepiness are urgently sought, particularly in the context of driving...
May 4, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28647486/geographically-weighted-negative-binomial-regression-applied-to-zonal-level-safety-performance-models
#2
Marcos José Timbó Lima Gomes, Flávio Cunto, Alan Ricardo Silva
Generalized Linear Models (GLM) with negative binomial distribution for errors, have been widely used to estimate safety at the level of transportation planning. The limited ability of this technique to take spatial effects into account can be overcome through the use of local models from spatial regression techniques, such as Geographically Weighted Poisson Regression (GWPR). Although GWPR is a system that deals with spatial dependency and heterogeneity and has already been used in some road safety studies at the planning level, it fails to account for the possible overdispersion that can be found in the observations on road-traffic crashes...
June 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28647270/polycyclic-aromatic-hydrocarbons-in-ambient-air-surface-soil-and-wheat-grain-near-a-large-steel-smelting-manufacturer-in-northern-china
#3
Weijian Liu, Yilong Wang, Yuanchen Chen, Shu Tao, Wenxin Liu
The total concentrations and component profiles of polycyclic aromatic hydrocarbons (PAHs) in ambient air, surface soil and wheat grain collected from wheat fields near a large steel-smelting manufacturer in Northern China were determined. Based on the specific isomeric ratios of paired species in ambient air, principle component analysis and multivariate linear regression, the main emission source of local PAHs was identified as a mixture of industrial and domestic coal combustion, biomass burning and traffic exhaust...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28646734/investigating-articulated-heavy-vehicle-crashes-in-western-australia-using-a-spatial-approach
#4
Ori Gudes, Richard Varhol, Qian Chayn Sun, Lynn Meuleners
BACKGROUND: Recent developments in Western Australia's economy including widespread traffic congestion as well as road safety issues are increasingly becoming prominent. Previous studies relied on traditional statistical methods to investigate patterns and characteristics of motor vehicle crashes. Although useful, statistical analysis alone is incapable of providing a spatial context and is therefore unable to associate existing crash characteristics with a spatial distribution. AIMS: To identify concentrations or "hotspots" of articulated heavy vehicle crashes in WA between the years 2001-2013, by using a spatial analysis approach...
June 21, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28646091/stress-specific-p38-map-kinase-activation-is-sufficient-to-drive-egf-receptor-endocytosis-but-not-nuclear-translocation
#5
Alejandra Tomas, Sylwia Jones, Simon O Vaughan, Daniel Hochhauser, Clare E Futter
P38 MAP kinase-dependent EGF receptor (EGFR) endocytosis is induced by stress. Ligand and stresses like X-rays, reportedly promote nuclear traffic of endocytosed EGFR for regulation of gene transcription and DNA repair. We fail to detect EGFR endocytosis or nuclear transport following X-ray treatment of HeLa or head and neck cancer cells, despite extensive DNA damage induction. Apparent nuclear staining with EGFR extracellular domain antibody remained present despite reduced/absent EGFR expression and so did not represent nuclear EGFR...
June 23, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28645709/aquatic-biodiversity-in-sedimentation-ponds-receiving-road-runoff-what-are-the-key-drivers
#6
Zhenhua Sun, John E Brittain, Ekaterina Sokolova, Helene Thygesen, Svein Jakob Saltveit, Sebastien Rauch, Sondre Meland
Recently, increased attention has been paid to biodiversity conservation provided by blue-green solutions such as engineered ponds that are primarily established for water treatment and flood control. However, little research has been done to analyse the factors that affect biodiversity in such ponds. The purpose of this study was to evaluate the influence of environmental factors on aquatic biodiversity, mainly macroinvertebrate communities, in road sedimentation ponds in order to provide a foundation for recommendations on aquatic biodiversity conservation...
June 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28645424/occurrence-of-selected-trace-metals-and-their-oral-bioaccessibility-in-urban-soils-of-kindergartens-and-parks-in-bratislava-slovak-republic-as-evaluated-by-simple-in-vitro-digestion-procedure
#7
Edgar Hiller, Martin Mihaljevič, Lenka Filová, Lucia Lachká, Ľubomír Jurkovič, Tatsiana Kulikova, Katarína Fajčíková, Mária Šimurková, Veronika Tatarková
A total of eighty surface soil samples were collected from public kindergartens and urban parks in the city of Bratislava, and the <150µm soil fraction was evaluated for total concentrations of five metals, Cd, Cu, Hg, Pb and Zn, their oral bioaccessibilities, non-carcinogenic and carcinogenic health risks to children, and lead isotopic composition. The mean metal concentrations in urban soils (0.29, 36.1, 0.13, 30.9 and 113mg/kg for Cd, Cu, Hg, Pb and Zn, respectively) were about two times higher compared with background soil concentrations...
June 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#8
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28645022/benzene-and-childhood-acute-leukemia-in-oklahoma
#9
Amanda E Janitz, Janis E Campbell, Sheryl Magzamen, Anne Pate, Julie A Stoner, Jennifer D Peck
BACKGROUND: Although childhood cancer is a leading cause of childhood mortality in the US, evidence regarding the etiology is lacking. The goal of this study was to evaluate the association between benzene, a known carcinogen, and childhood acute leukemia. METHODS: We conducted a case-control study including cases diagnosed with acute leukemia between 1997 and 2012 (n = 307) from the Oklahoma Central Cancer Registry and controls matched on week of birth from birth certificates (n = 1013)...
June 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28644882/a-spatially-explicit-risk-assessment-approach-cetaceans-and-marine-traffic-in-the-pelagos-sanctuary-mediterranean-sea
#10
Maria Grazia Pennino, Antonella Arcangeli, Vinícius Prado Fonseca, Ilaria Campana, Graham J Pierce, Andrea Rotta, Jose Maria Bellido
Spatially explicit risk assessment is an essential component of Marine Spatial Planning (MSP), which provides a comprehensive framework for managing multiple uses of the marine environment, minimizing environmental impacts and conflicts among users. In this study, we assessed the risk of the exposure to high intensity vessel traffic areas for the three most abundant cetacean species (Stenella coeruleoalba, Tursiops truncatus and Balaenoptera physalus) in the southern area of the Pelagos Sanctuary, which is the only pelagic Marine Protected Area (MPA) for marine mammals in the Mediterranean Sea...
2017: PloS One
https://www.readbyqxmd.com/read/28644400/evaluation-of-sources-and-patterns-of-elemental-composition-of-pm2-5-at-three-low-income-neighborhood-schools-and-residences-in-quito-ecuador
#11
Amit U Raysoni, Rodrigo X Armijos, M Margaret Weigel, Patricia Echanique, Marcia Racines, Nicholas E Pingitore, Wen-Whai Li
Elemental characterization of fine particulate matter was undertaken at schools and residences in three low income neighborhoods in Quito, Ecuador. The three zones were located in the northern (Cotocollao), south central (El Camal), and south east (Los Chillos) neighborhoods and were classified as zones 1-3, respectively. Forty elements were quantified via ICP-MS analysis. Amongst the geogenic elements, the concentration of Si was the most abundant followed by S, Al, and Ca. Elements with predominantly anthropogenic sources such as Zn, V, and Ni were higher in zone 3 school followed by zone 2 and zone 1 schools...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28642759/biodistribution-and-efficacy-of-human-adipose-derived-mesenchymal-stem-cells-following-intranodal-administration-in-experimental-colitis
#12
Mercedes Lopez-Santalla, Pablo Mancheño-Corvo, Amelia Escolano, Ramon Menta, Olga DelaRosa, Jose Luis Abad, Dirk Büscher, Juan M Redondo, Juan A Bueren, Wilfried Dalemans, Eleuterio Lombardo, Marina I Garin
Mesenchymal stem cells (MSCs) have a large potential in cell therapy for treatment of inflammatory and autoimmune diseases, thanks to their immunomodulatory properties. The encouraging results in animal models have initiated the translation of MSC therapy to clinical trials. In cell therapy protocols with MSCs, administered intravenously, several studies have shown that a small proportion of infused MSCs can traffic to the draining lymph nodes (LNs). This is accompanied with an increase of different types of regulatory immune cells in the LNs, suggesting the importance of migration of MSCs to the LNs in order to contribute to immunomodulatory response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28641252/an-embedded-marked-point-process-framework-for-three-level-object-population-analysis
#13
Csaba Benedek
In this paper we introduce a probabilistic approach for extracting complex hierarchical object structures from digital images used by various vision applications. The proposed framework extends conventional Marked Point Process (MPP) models by (i) admitting object-subobject ensembles in parent-child relationships and (ii) allowing corresponding objects to form coherent object groups, by a Bayesian segmentation of the population. Different from earlier, highly domain specific attempts on MPP generalization, the proposed model is defined at an abstract level, providing clear interfaces for applications in various domains...
June 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28640879/dual-targeting-of-a-virus-movement-protein-to-er-and-plasma-membrane-subdomains-is-essential-for-plasmodesmata-localization
#14
Kazuya Ishikawa, Masayoshi Hashimoto, Akira Yusa, Hiroaki Koinuma, Yugo Kitazawa, Osamu Netsu, Yasuyuki Yamaji, Shigetou Namba
Plant virus movement proteins (MPs) localize to plasmodesmata (PD) to facilitate virus cell-to-cell movement. Numerous studies have suggested that MPs use a pathway either through the ER or through the plasma membrane (PM). Furthermore, recent studies reported that ER-PM contact sites and PM microdomains, which are subdomains found in the ER and PM, are involved in virus cell-to-cell movement. However, functional relationship of these subdomains in MP traffic to PD has not been described previously. We demonstrate here the intracellular trafficking of fig mosaic virus MP (MPFMV) using live cell imaging, focusing on its ER-directing signal peptide (SPFMV)...
June 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28640867/correction-l-ferritin-binding-to-scara5-a-new-iron-traffic-pathway-potentially-implicated-in-retinopathy
#15
Luísa Mendes-Jorge, David Ramos, Andreia Valença, Mariana López-Luppo, Virgínia Maria Rico Pires, Joana Catita, Victor Nacher, Marc Navarro, Ana Carretero, Alfonso Rodriguez-Baeza, Jesús Ruberte
[This corrects the article DOI: 10.1371/journal.pone.0106974.].
2017: PloS One
https://www.readbyqxmd.com/read/28640685/understanding-and-improving-arterial-roads-to-support-public-health-and-transportation-goals
#16
Carolyn McAndrews, Keshia M Pollack, David Berrigan, Andrew L Dannenberg, Ed J Christopher
Arterials are types of roads designed to carry high volumes of motorized traffic. They are an integral part of transportation systems worldwide and exposure to them is ubiquitous, especially in urban areas. Arterials provide access to diverse commercial and cultural resources, which can positively influence community health by supporting social cohesion as well as economic and cultural opportunities. They can negatively influence health via safety issues, noise, air pollution, and lack of economic development...
June 22, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28640679/crash-fatality-rates-after-recreational-marijuana-legalization-in-washington-and-colorado
#17
Jayson D Aydelotte, Lawrence H Brown, Kevin M Luftman, Alexandra L Mardock, Pedro G R Teixeira, Ben Coopwood, Carlos V R Brown
OBJECTIVES: To evaluate motor vehicle crash fatality rates in the first 2 states with recreational marijuana legalization and compare them with motor vehicle crash fatality rates in similar states without recreational marijuana legalization. METHODS: We used the US Fatality Analysis Reporting System to determine the annual numbers of motor vehicle crash fatalities between 2009 and 2015 in Washington, Colorado, and 8 control states. We compared year-over-year changes in motor vehicle crash fatality rates (per billion vehicle miles traveled) before and after recreational marijuana legalization with a difference-in-differences approach that controlled for underlying time trends and state-specific population, economic, and traffic characteristics...
June 22, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28638384/induced-regulatory-t-cells-superimpose-their-suppressive-capacity-with-effector-t-cells-in-lymph-nodes-via-antigen-specific-s1p1-dependent-egress-blockage
#18
Shuang Geng, Yiwei Zhong, Xiaoyu Zhou, Gan Zhao, Xiaoping Xie, Yechun Pei, Hu Liu, Huiyuan Zhang, Yan Shi, Bin Wang
Regulatory T cells (Tregs) restrict overexuberant lymphocyte activation. While close proximity between Tregs and their suppression targets is important for optimal inhibition, and literature indicates that draining lymph nodes (LNs) may serve as a prime location for the suppression, signaling details orchestrating this event are not fully characterized. Using a protocol to enable peripheral generation of inducible antigen-specific Tregs (asTregs) to control allergen-induced asthma, we have identified an antigen-specific mechanism that locks asTregs within hilar LNs which in turn suppresses airway inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28636489/evaluation-of-countermeasures-for-red-light-running-by-traffic-simulator-based-surrogate-safety-measures
#19
Changju Lee, Jaehyun Jason So, Jiaqi Ma
OBJECTIVE: The conflicts among motorists entering a signalized intersection with the red light indication have become a national safety issue. Because of its sensitivity, efforts have been made to investigate the possible causes and effectiveness of countermeasures by the comparison sites and/or before-and-after studies. Nevertheless, these approaches are ineffective when comparison sites cannot be found, or crash data sets are not readily available or not reliable for statistical analysis...
June 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28635868/-the-modern-possibilities-for-the-application-of-photogrammetry-in-forensic-medical-traumatology
#20
V A Fetisov, I Yu Makarov, A A Gusarov, A S Lorents, S A Smirenin, V B Stragis
The authors discuss the modern possibilities and prospects for the application of photogrammetry (FM) in forensic medical traumatology based on the results of the analysis of the many-year experience reported in the foreign periodicals with special reference to road traffic injuries, gunshot wounds, and animals' bites. The examples of objective difficulties and promising prospects for the further application of the FM techniques in the practical work of forensic medical experts and medical criminalists are considered with reference to the use of various FM-based methods and equipment including 3D laser scanners, chambers, stereoscopic mounting attachments, etc...
2017: Sudebno-meditsinskaia Ekspertiza
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