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https://www.readbyqxmd.com/read/29352299/bunyavirus-requirement-for-endosomal-k-reveals-new-roles-of-cellular-ion-channels-during-infection
#1
Samantha Hover, Becky Foster, Juan Fontana, Alain Kohl, Steve A N Goldstein, John N Barr, Jamel Mankouri
In order to multiply and cause disease a virus must transport its genome from outside the cell into the cytosol, most commonly achieved through the endocytic network. Endosomes transport virus particles to specific cellular destinations and viruses exploit the changing environment of maturing endocytic vesicles as triggers to mediate genome release. Previously we demonstrated that several bunyaviruses, which comprise the largest family of negative sense RNA viruses, require the activity of cellular potassium (K+) channels to cause productive infection...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29351393/liver-tissue-metabolically-transformed-by-alcohol-induces-immune-recognition-of-liver-self-proteins-but-not-in-vivo-inflammation
#2
Michael J Duryee, Benjamin M Wiese, Jordan R Bowman, Jared D Vanlandingham, Lynell W Klassen, Geoffrey E Thiele, Carlos D Hunter, Daniel R Anderson, Ted R Mikuls, Geoffrey M Thiele
Precision cut liver slices (PCLSs) provide a novel model for studies in alcoholic liver disease (ALD). This is relevant, as in vivo ethanol exposure does not appear to generate significant liver damage in ethanol fed mice, except in the NIAAA binge model of ALD. Previous studies have shown that the two metabolites of ethanol consumption, malondialdhyde (MDA) and acetaldehyde (AA), combine to form (MAA), which has been correlated with the development and progression of ALD. In this study murine PCLSs were incubated with ethanol and examined for the production of MAA...
December 28, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29351267/motorcycle-that-see-multifocal-stereo-vision-sensor-for-advanced-safety-systems-in-tilting-vehicles
#3
Gustavo Gil, Giovanni Savino, Simone Piantini, Marco Pierini
Advanced driver assistance systems, ADAS, have shown the possibility to anticipate crash accidents and effectively assist road users in critical traffic situations. This is not the case for motorcyclists, in fact ADAS for motorcycles are still barely developed. Our aim was to study a camera-based sensor for the application of preventive safety in tilting vehicles. We identified two road conflict situations for which automotive remote sensors installed in a tilting vehicle are likely to fail in the identification of critical obstacles...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29350368/clinical-features-diagnosis-and-treatment-of-traumatic-pulmonary-pseudocysts
#4
Seray Hazer, Umut Perçem Orhan Söylemez
BACKGROUND: Traumatic pulmonary pseudocysts (TPP) are rare complications of blunt chest trauma. The aim of this study is to increase the understanding of this rare entity with imaging and clinical parameters for preventing complications and determining the correct treatment approach by observing 15 cases. METHODS: We retrospectively reviewed the medical data and thoracic computed tomography scans of 185 patients who underwent examinations in our department after chest trauma between July 2014 and December 2015...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350061/the-adverse-effects-of-environmental-noise-exposure-on-oxidative-stress-and-cardiovascular-risk
#5
Thomas Münzel, Mette Sørensen, Frank P Schmidt, Erwin Schmidt, Sebastian Steven, Swenja Kröller-Schön, Andreas Daiber
Epidemiological studies have provided evidence that traffic noise exposure is linked to cardiovascular diseases such as arterial hypertension, myocardial infarction and stroke. Noise is a non-specific stressor that activates the autonomous nervous system and endocrine signaling. According to the noise reaction model introduced by Babisch and colleagues, chronic low levels of noise can cause so called non-auditory effects, such as disturbances of activity, sleep and communication, which can trigger a number of emotional responses, including annoyance and subsequent stress...
January 19, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29350008/-surgical-treatment-for-open-tarsometatarsal-joint-injury
#6
Yang-Hua Tang, Lin-Ru Zeng, Zhen-Shuang Yue, Da-Wei Xin, Zhong-Qing Hu, Can-da Xu
OBJECTIVE: To discuss the surgical method and clinical efficacy for open tarsometatarsal joint injuries. METHODS: From March 2011 to January 2015, 21 patients with open tarsometatarsal joint injuries were treated with stage-surgery method, including 14 males and 7 females with an average age of 45.6 years old ranging from 20 to 75 years. Injury site occurred in the left foot of 13 cases and right foot of 8 cases. Traffic injury was in 5 cases, crush injury in 6 cases, heavy crushing was in 10 cases...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349966/-a-medium-term-therapeutic-effects-of-anatomic-locking-plate-for-femoral-intertrochanteric-with-lateral-femoral-wall-fractures
#7
Jin-Wei Xu, Lei Han, Yun-Gen Hu, Wei-Li Fang, Bo Ji
OBJECTIVE: To retrospectively study medium term follow-up outcomes of the femoral intertrochanteric with lateral femoral wall fractures using anatomic locking plate fixation. METHODS: From June 2010 to January 2013, 18 cases of the unstable femoral intertrochanteric with lateral femoral wall fractures were treated with the anatomic locking plate, included 8 males and 10 females with an average age of 75.5 years ranging from 19 to 83 years old. There were 8 cases of traffic accident injuries, 6 cases of falls injuries, and 4 cases of falling from high place...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349487/lay-first-responder-training-in-eastern-uganda-leveraging-transportation-infrastructure-to-build-an-effective-prehospital-emergency-care-training-program
#8
Peter G Delaney, Richard Bamuleke, Yang Jae Lee
BACKGROUND: Though road traffic injuries (RTIs) are a major cause of mortality in East Africa, few countries have emergency medical services. The aim was to create a sustainable and efficient prehospital lay first responder program, creating a system with lay first responders spread through the 53 motorcycle taxi stages of Iganga Municipality. METHODS: One hundred and fifty-four motorcycle taxi riders were taught a first aid curriculum in partnership with a local Red Cross first aid trainer and provided with a first aid kit following WHO guidelines for basic first aid...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29349204/validity-of-a-scale-of-neighbourhood-informal-social-control-relevant-to-pre-schoolers-physical-activity-a-cross-sectional-study
#9
Ester Cerin, Yi Nam Suen, Anthony Barnett, Wendy Y J Huang, Robin R Mellecker
Childhood physical activity (PA) is important for health across the lifespan. Time pre-schoolers spend outdoors, which has been associated with more PA, is likely influenced by parents' perception of neighbourhood informal social control relevant to pre-schoolers' PA, defined as the willingness of neighbours to intervene to ensure social order and a safe community environment for young children's active play. To advance measurement of this construct, we assessed factorial and construct validities of the PA-related neighbourhood informal social control scale for parents of pre-schoolers (PANISC-PP)...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29347941/a-five-year-retrospective-study-of-the-epidemiological-characteristics-and-visual-outcomes-of-pediatric-ocular-trauma
#10
Edita Puodžiuvienė, Giedrė Jokūbauskienė, Monika Vieversytė, Kirwan Asselineau
BACKGROUND: Pediatric trauma can lead to serious visual impairment as a result of the trauma itself or secondary to amblyopia. Precise data on epidemiological characteristics and visual outcomes of pediatric ocular injuries are valuable for the prevention of monocular blindness. METHODS: A total of 268 cases of pediatric ocular trauma admitted to the Department of Ophthalmology of the Lithuanian University of Health Sciences Hospital from January 2008 to December 2013 were retrospectively reviewed...
January 18, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29347691/dynamics-of-functional-failures-and-recovery-in-complex-road-networks
#11
Xianyuan Zhan, Satish V Ukkusuri, P Suresh C Rao
We propose a new framework for modeling the evolution of functional failures and recoveries in complex networks, with traffic congestion on road networks as the case study. Differently from conventional approaches, we transform the evolution of functional states into an equivalent dynamic structural process: dual-vertex splitting and coalescing embedded within the original network structure. The proposed model successfully explains traffic congestion and recovery patterns at the city scale based on high-resolution data from two megacities...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346527/progesterone-effects-on-extracellular-vesicles-in-the-sheep-uterus
#12
Gregory W Burns, Kelsey E Brooks, Eleanore V O'Neil, Darren E Hagen, Susanta K Behura, Thomas E Spencer
Progesterone (P4) acts via the endometrium to promote conceptus growth and implantation for pregnancy establishment. Many cells release extracellular vesicles (EVs) that are membrane-bound vesicles of endosomal and plasma membrane origin. In sheep, endometrial-derived EVs were found to traffic to the conceptus trophectoderm. Thus, EVs are hypothesized to be an important mode of intercellular communication by transferring select RNAs, proteins, and lipids between the endometrium and conceptus. Electron microscopy analysis found that the endometrial luminal and glandular epithelia were the primary source of EVs in the uterus of cyclic sheep...
January 16, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29346418/the-relationship-of-lung-function-with-ambient-temperature
#13
Joseph M Collaco, Lawrence J Appel, John McGready, Garry R Cutting
BACKGROUND: Lung function is complex trait with both genetic and environmental factors contributing to variation. It is unknown how geographic factors such as climate affect population respiratory health. OBJECTIVE: To determine whether ambient air temperature is associated with lung function (FEV1) in the general population. DESIGN/SETTING: Associations between spirometry data from two National Health and Nutrition Examination Survey (NHANES) periods representative of the U...
2018: PloS One
https://www.readbyqxmd.com/read/29346399/the-motivation-based-calving-facility-social-and-cognitive-factors-influence-isolation-seeking-behaviour-of-holstein-dairy-cows-at-calving
#14
Maria Vilain Rørvang, Mette S Herskin, Margit Bak Jensen
In order to improve animal welfare it is recommended that dairy farmers move calving cows from the herd to individual pens when calving is imminent. However, the practicality of moving cows has proven a challenge and may lead to disturbance of the cows rather than easing the process of calving. One solution may be to allow the cow to seek isolation prior to calving. This study examined whether pre-parturient dairy cows will isolate in an individual calving pen placed in a group calving setting and whether a closing gate in this individual calving pen will cause more cows to isolate prior to calving...
2018: PloS One
https://www.readbyqxmd.com/read/29346318/differences-between-outdoor-and-indoor-sound-levels-for-open-tilted-and-closed-windows
#15
Barbara Locher, André Piquerez, Manuel Habermacher, Martina Ragettli, Martin Röösli, Mark Brink, Christian Cajochen, Danielle Vienneau, Maria Foraster, Uwe Müller, Jean Marc Wunderli
Noise exposure prediction models for health effect studies normally estimate free field exposure levels outside. However, to assess the noise exposure inside dwellings, an estimate of indoor sound levels is necessary. To date, little field data is available about the difference between indoor and outdoor noise levels and factors affecting the damping of outside noise. This is a major cause of uncertainty in indoor noise exposure prediction and may lead to exposure misclassification in health assessments. This study aims to determine sound level differences between the indoors and the outdoors for different window positions and how this sound damping is related to building characteristics...
January 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29346237/pediatric-pelvic-fractures-and-differences-compared-with-the-adult-population
#16
Carolina de la Calva, Nadia Jover, Jaime Alonso, Marta Salom
INTRODUCTION: Although pelvic fractures in children are rare, because of anatomical differences between an adult's skeleton and a child's skeleton, these lesions in the pediatric population have specific characteristics that need to be borne in mind when dealing with them. MATERIALS AND METHODS: A retrospective chart review was performed on the pelvic fractures in skeletally immature patients treated in our hospital in the last 20 years. RESULTS: Eighty-one pelvic fractures in children were treated between 1993 and 2013...
January 16, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29346084/effects-of-the-road-environment-on-the-development-of-driver-sleepiness-in-young-male-drivers
#17
Christer Ahlström, Anna Anund, Carina Fors, Torbjörn Åkerstedt
Latent driver sleepiness may in some cases be masked by for example social interaction, stress and physical activity. This short-term modulation of sleepiness may also result from environmental factors, such as when driving in stimulating environments. The aim of this study is to compare two road environments and investigate how they affect driver sleepiness. Thirty young male drivers participated in a driving simulator experiment where they drove two scenarios: a rural environment with winding roads and low traffic density, and a suburban road with higher traffic density and a more built-up roadside environment...
January 12, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29346078/long-term-high-air-pollution-exposure-induced-metabolic-adaptations-in-traffic-policemen
#18
Chaochao Tan, Yupeng Wang, Mingyue Lin, Zhu Wang, Li He, Zhiyi Li, Yu Li, Keqian Xu
OBJECTIVE: To assess the adverse physiological changes induced by long-term exposure to PM2.5. METHODS: Totally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study...
January 5, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29342483/-fitness-to-drive-after-stroke
#19
Peter Marx
In Germany, patient information and expert testimony on driving ability requires knowledge of the corresponding legislation and the Guideline for expertises on driver aptitude. The testimony should clearly identify handicaps with regard to driving, give estimates on the future risks of a sudden loss of control, and also consider personal attitudes such as inadequate behavior, lack of insight etc. Physical handicaps often can be compensated for by restrains or restrictions such as vehicle modifications, daylight driving only etc...
January 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29342208/comparison-of-traffic-injury-related-hospitalisation-between-bicyclists-and-motorcyclists-in-taiwan
#20
Chih-Wei Pai, Hsiao-Yu Lin, Shin-Han Tsai, Ping-Ling Chen
OBJECTIVES: Bicyclists and motorcyclists contribute substantially to the morbidity and mortality rates of road crash casualties. The objective of the study was to investigate the crash characteristics of bicyclist and motorcyclist casualties presented to hospitals in Taiwan resulting from crashes. METHODS: By using linked data from The National Traffic Crash Dataset and the National Health Insurance Database between 2003 and 2012, logistic regression models were used to examine the determinants of hospitalisation among motorcyclist and bicyclist casualties...
2018: PloS One
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