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https://www.readbyqxmd.com/read/28431846/implementation-of-daily-chlorhexidine-bathing-to-reduce-colonization-by-multidrug-resistant-organisms-in-a-critical-care-unit
#1
Jackson S Musuuza, Ajay K Sethi, Tonya J Roberts, Nasia Safdar
BACKGROUND: Colonized patients are a reservoir for transmission of multidrug-resistant organisms (MDROs). Not many studies have examined the effectiveness of daily chlorhexidine gluconate (CHG) bathing under routine care conditions. We present a descriptive analysis of the trends of MDRO colonization following implementation of daily CHG bathing under routine clinical conditions in an intensive care unit (ICU). METHODS: From May 2010-January 2011, we screened patients admitted to a 24-bed ICU for and methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and fluoroquinolone-resistant gram-negative bacilli (FQRGNB)...
April 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28422796/waterless-hand-rub-versus-traditional-hand-scrub-methods-for-preventing-the-surgical-site-infection-in-orthopaedic-surgery
#2
Kentaro Iwakiri, Akio Kobayashi, Masahiko Seki, Yoshiyuki Ando, Tadao Tsujio, Masatoshi Hoshino, Hiroaki Nakamura
STUDY DESIGN: A retrospective cohort study with prospectively collected data OBJECTIVE.: The aim of this study was to compare SSI incidences, the cost of hand hygiene agents, and hand hygiene time between the traditional hand scrub and the waterless hand rub protocols before orthopaedic surgery. SUMMARY OF BACKGROUND DATA: Surgical-site-infections (SSI) prolong hospitalization and are a leading nosocomial cause of morbidity as well as a source of excess cost. Recently, a waterless hand rub protocol comprising alcohol based chlorhexidine gluconate for use before surgery was developed, but no studies have yet examined its utility in orthopaedic surgery...
April 18, 2017: Spine
https://www.readbyqxmd.com/read/28415444/formulation-of-thermoreversible-gel-of-cranberry-juice-concentrate-evaluation-biocompatibility-studies-and-its-antimicrobial-activity-against-periodontal-pathogens
#3
Rajeshwari H R, Dinesh Dhamecha, Satveer Jagwani, Dhanashree Patil, Satisha Hegde, Raksha Potdar, Renuka Metgud, Sunil Jalalpure, Subarna Roy, Kiran Jadhav, Neeraj Kumar Tiwari, Sravani Koduru, Shweta Hugar, Suneel Dodamani
The present work aims to investigate the efficacy of thermoreversible gel of cranberry juice concentrate (CJC) as local drug delivery for the treatment of periodontitis. CJC was initially tested for its antimicrobial activities like MIC, MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms (S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis (PG), T. forsythia (TF)) responsible for periapical and periodontal infections. Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28397616/analysis-of-multidrug-resistant-organism-susceptibility-to-chlorhexidine-under-usual-clinical-care
#4
Jackson S Musuuza, Ajay K Sethi, Tonya J Roberts, Nasia Safdar
Increasing use of daily chlorhexidine gluconate (CHG) bathing can potentially lead to selection for organisms with reduced susceptibility to CHG, limiting the utility of CHG. We examined reduced susceptibility to CHG of fluoroquinolone-resistant gram-negative bacilli and methicillin-resistant Staphylococcus. No evidence suggested reduced susceptibility to CHG. Infect Control Hosp Epidemiol 2017;1-3.
April 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28341500/effect-of-2-chlorhexidine-gluconate-impregnated-cloth-on-surgical-site-infections-in-vascular-surgery
#5
John Bak, Jason Le, Toshio Takayama, Angela Gibson, Sara Zerbel, Nasia Safdar, Jon Matsumura
OBJECTIVE: Surgical site infections (SSI) are a significant burden to patients and healthcare systems. This retrospective study evaluates the observed rates of SSI after our institution implemented chlorhexidine gluconate-impregnated (CHG) cloth as a preoperative antiseptic preparation in elective vascular surgery. METHODS: Between March 2011 and January 2012, we reviewed 250 patients who underwent elective vascular surgery who used the CHG cloth preoperatively...
March 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28334482/minimising-central-line-associated-bloodstream-infections-clabsis-rate-in-inserting-central-venous-catheters-cvcs-in-the-adult-intensive-care-units-aicus
#6
REVIEW
Hedaya Hina, Joan McDowell
AIM: To investigate the procedural aspects in inserting central venous catheters that minimise central line associated bloodstream infections rates in adult intensive care units through a structured literature review. BACKGROUND: In adult intensive care units (AICU), central line associated bloodstream infections (CLABSI) are a major cause of high mortality rates and increased in costs due to the consequences of complications. METHODS: Eligible articles were identified by combining indexed keywords using Boolean operator of "AND" under databases of Ovid and CINAHL...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28327805/antifungal-activity-of-synthetic-antiseptics-and-natural-compounds-against-candida-dubliniensis-before-and-after-in-vitro-fluconazole-exposure
#7
Cássia Franco Reginato, Laíssa Arévalo Bandeira, Régis Adriel Zanette, Janio Morais Santurio, Sydney Hartz Alves, Cristiane Cademartori Danesi
INTRODUCTION: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). METHODS: Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28300045/-nature-cures-an-alternative-herbal-formulation-as-a-denture-cleanser
#8
RANDOMIZED CONTROLLED TRIAL
R Sushma, Tanuja Tanaji Sathe, Anand Farias, Pronob Kumar Sanyal, Shashi Kiran
BACKGROUND: Candida albicans is one of the microorganisms which harbor the oral cavity, especially in elderly. However, the incidence of existence of this increases in patients using removable dental prosthesis. There is therefore a need to test the anticandidal efficacy of these cost-effective, easily available products to be used as routine denture cleansers. AIM AND OBJECTIVES: (1) To evaluate antifungal properties of triphala churna on the heat cure denture base material...
January 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28281934/integron-occurrence-is-linked-to-reduced-biocide-susceptibility-in-multidrug-resistant-pseudomonas-aeruginosa
#9
Ashraf A Kadry, Fathy M Serry, Amira M El-Ganiny, Ahmed M El-Baz
OBJECTIVE: Integrons are gene acquisition systems commonly found in bacterial genomes that play a major role in the dissemination of resistance to antibiotics. This work aimed to study the relationship between the presence of integrons and the reduced susceptibility of multidrug-resistant (MDR) Pseudomonas aeruginosa isolates towards different groups of biocides. METHODS: The antimicrobial susceptibility patterns of 104 clinical isolates were determined against different antibiotics by the disk diffusion method...
April 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28229586/chlorhexidine-loaded-amorphous-calcium-phosphate-nanoparticles-for-inhibiting-degradation-and-inducing-mineralization-of-type-i-collagen
#10
Xue Cai, Bing Han, Yan Liu, Fucong Tian, Fuxin Liang, Xiaoyan Wang
A major shortcoming of contemporary dentin adhesives is their limited durability. Exposed collagen fibrils within the bonding interface are degraded by matrix metalloproteinases (MMPs), resulting in aging of the resin-dentin bond. In this study, chlorhexidine-loaded amorphous calcium phosphate (ACP) nanoparticles were synthesized to induce the mineralization of collagen fibrils. The nanoparticles sustainably released chlorhexidine to inhibit MMPs during mineralization. Three types of ACP nanoparticles were prepared: N-ACP containing no chlorhexidine, C-ACP containing chlorhexidine acetate, and G-ACP containing chlorhexidine gluconate, which had a higher drug-loading than C-ACP...
April 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28218496/functional-analysis-of-bioactivated-and-antiinfective-pdlla-coated-surfaces
#11
Selgai Haidari, Marko Boskov, Ulrike Schillinger, Oliver Bissinger, Klaus-Dietrich Wolff, Christian Plank, Andreas Kolk
Common scaffold surfaces such as titanium can have side effects; for example, infections, cytotoxicity, impaired osseointegration, or low regeneration rates for bone tissue. These effects lead to poor implant integration or even implant loss. Therefore, bioactive implants are promising instruments in tissue regeneration. Osteoinductive elements-such as growth factors and anti-infectives-support wound healing and bone growth and thereby enable faster osseointegration, even in elderly patients. In this study, titanium surfaces were coated with a poly-(d,l-lactide) (PDLLA) layer containing different concentrations of copolymer-protected gene vectors (COPROGs) to locally provide bone morphogenetic protein-2 (BMP-2) or activated anti-infective agents, such as chlorhexidine gluconate, triclosan, and metronidazole, to prevent peri-implantitis...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28218483/antimicrobial-potential-and-gustatory-perception-of-chlorhexidine-gluconate-mouthwashes-with-or-without-alcohol-after-a-single-rinse-a-randomized-controlled-crossover-clinical-trial
#12
R Cantarelli, T C Negrini, Fwmg Muniz, Hjr Oballe, R A Arthur, C K Rösing
OBJECTIVE: The aim of this double-blind randomized clinical trial was to assess whether the presence of alcohol in chlorhexidine gluconate mouthwashes influences their antimicrobial potential against salivary bacteria in young adults. Additionally, the taste perception was assessed. MATERIALS AND METHODS: In a randomized crossover design, 20 participants (17 women and three men; aged 18-38 years old) rinsed with the 0.12% chlorhexidine gluconate with (CHX+) or without alcohol (CHX-) for 1 min...
November 7, 2016: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28173880/an-observational-study-to-compare-oral-hygiene-care-with-chlorhexidine-gluconate-gel-versus-mouthwash-to-prevent-ventilator-associated-pneumonia
#13
Hung-Jen Tang, Chien-Ming Chao, Pak-On Leung, Chih-Cheng Lai
No abstract text is available yet for this article.
February 8, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28164099/chlorhexidine-gluconate-use-to-prevent-hospital-acquired-infections-a-useful-tool-not-a-panacea
#14
COMMENT
Elizabeth Wenqian Wang, A Joseph Layon
No abstract text is available yet for this article.
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28159381/reduction-in-chlorhexidine-efficacy-against-multi-drug-resistant-acinetobacter-baumannii-international-clone%C3%A2-ii
#15
M Hayashi, K Kawamura, M Matsui, M Suzuki, S Suzuki, K Shibayama, Y Arakawa
BACKGROUND: Nosocomial infections caused by Acinetobacter baumannii international clone II (IC II) can cause severe clinical outcomes. AIM: Differential evaluation of bactericidal efficacy of chlorhexidine gluconate (CHX) and benzethonium chloride (BZT) disinfectants against IC II and non-IC II isolates. METHODS: Minimum inhibitory concentrations (MICs) of CHX and BZT were determined for 137 A. baumannii IC II, 99 non-IC II and 69 non-baumannii isolates, further classified according to MIC values into disinfectant-reduced susceptible (DRS) and disinfectant-susceptible (DS) groups...
March 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28149868/every-other-day-bathing-with-chlorhexidine-gluconate-what-is-the-evidence
#16
EDITORIAL
Jackson S Musuuza, Nasia Safdar
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28142218/differential-effects-of-the-combination-of-tyrosol-with-chlorhexidine-gluconate-on-oral-biofilms
#17
L R do Vale, Acb Delbem, L S Arias, R A Fernandes, Apm Vieira, D B Barbosa, D R Monteiro
OBJECTIVE: This study assessed the effect of tyrosol and chlorhexidine gluconate in combination against Candida albicans, Candida glabrata, and Streptococcus mutans in the planktonic state or forming biofilms in vitro. MATERIALS AND METHODS: Checkerboard assays were performed for determination of minimum inhibitory concentration. Biofilms were cultivated during 24 h on specimens of acrylic resin and hydroxyapatite and treated with the drugs alone or in combination twice a day for 1 min, during 3 days...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28127166/antimicrobial-activity-of-endodontic-medicaments-and-vehicles-using-agar-well-diffusion-method-on-facultative-and-obligate-anaerobes
#18
Triveni M Nalawade, Kishore G Bhat, Suma Sogi
AIMS: The aim of this study was to determine the relative antimicrobial effectiveness of these endodontic medicaments and various vehicles using an agar well diffusion assay. MATERIALS AND METHODS: Double Antibiotic Paste(DAP), modified DAP, 2% Chlorhexidine gluconate and their combination with four vehicles namely Polyethylene glycol 400 (PEG), Propylene glycol (PG), combinations of PG with PEG and lastly Glycerine were tested using agar well diffusion assay. The minimum bactericidal concentration was noted against four standard strains of organisms ie Streptococcus mutans ATCC( American Type Culture Collection) 25175, Staphylococcus aureus ATCC 12598, Enterococcus faecalis ATCC 35550 and Eschericia coli ATCC 25922...
October 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28107301/implementation-of-a-pediatric-orthopaedic-bundle-to-reduce-surgical-site-infections
#19
Jan Schriefer, James Sanders, Julie Michels, Kori Wolcott, Connor Ruddy, Jenna Hanson
Surgical site infections (SSIs) cost an estimated $27,288 per case. An analysis of the National Surgical Quality Improvement Program data at the University of Rochester Medical Center suggested that rates of SSIs could be lowered in comparison with both peers and baseline. The aim of this study was to reduce the number of SSIs to zero through the implementation of a "bundle" or a combination of practices. Meetings were held with the multidisciplinary care team that includes surgeons and staff from pediatric pharmacy, pediatric infectious diseases, anesthesia, and nursing to create a care bundle for all pediatric orthopaedic surgery patients...
January 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28096000/effects-of-oral-care-with-glutamine-in-preventing-ventilator-associated-pneumonia-in-neurosurgical-intensive-care-unit-patients
#20
Hatice Kaya, Yüksel Turan, Yusuf Tunalı, Gülsün Özdemir Aydın, Neslihan Yüce, Şengül Gürbüz, Keziban Tosun
PURPOSE: The study was designed as a randomized, controlled, experimental study aiming to determine the effects of oral care with glutamine in preventing ventilator-associated pneumonia in patients admitted to neurosurgical intensive care unit. METHODS: The universe consisted of patients who are admitted to neurosurgical intensive care unit between January 2014 and August 2015, while the sample consisted of 88 patients who fulfilled the inclusion criteria and were randomly selected...
February 2017: Applied Nursing Research: ANR
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