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https://www.readbyqxmd.com/read/29352750/histomorphological-analysis-of-the-variability-of-the-human-skeleton-forensic-implications
#1
Marco Cummaudo, Annalisa Cappella, Miranda Biraghi, Caterina Raffone, Nicholas Màrquez-Grant, Cristina Cattaneo
One of the fundamental questions in forensic medicine and anthropology is whether or not a bone or bone fragment is human. Surprisingly at times for the extreme degradation of the bone (charred, old), DNA cannot be successfully performed and one must turn to other methods. Histological analysis at times can be proposed. However, the variability of a single human skeleton has never been tested. Forty-nine thin sections of long, flat, irregular and short bones were obtained from a well-preserved medieval adult human skeleton...
January 20, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29342008/the-r2c2-model-in-residency-education-how-does-it-foster-coaching-and-promote-feedback-use
#2
Joan Sargeant, Jocelyn M Lockyer, Karen Mann, Heather Armson, Andrew Warren, Marygrace Zetkulic, Sophie Soklaridis, Karen D Könings, Kathryn Ross, Ivan Silver, Eric Holmboe, Cindy Shearer, Michelle Boudreau
PURPOSE: The authors previously developed and tested a reflective model for facilitating performance feedback for practice improvement, the R2C2 model. It consists of four phases: relationship building, exploring reactions, exploring content, and coaching. This research studied the use and effectiveness of the model across different residency programs and the factors that influenced its effectiveness and use. METHOD: From July 2014-October 2016, case study methodology was used to study R2C2 model use and the influence of context on use within and across five cases...
January 16, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29338973/asthma-copd-overlap-a-portuguese-survey
#3
E Padrão, D Araújo, A Todo Bom, C Robalo Cordeiro, J Correia de Sousa, J Cardoso, M Morais-Almeida, R Costa, F Pavão, R B Leite, A Marques
INTRODUCTION: The overlap between asthma and chronic obstructive pulmonary disease (COPD) (ACO) has been discussed for many years but clinical recommendations for this entity have been diverse. This study is intended to reach a consensus on diagnosis, treatment and patient orientation for ACO, within the Portuguese medical community. METHODS: This study was conducted by a multidisciplinary panel of experts from three distinct medical specialties (Pulmonology, Family Medicine and Immunoallergology)...
January 12, 2018: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29338240/biki-life-sciences-a-new-suite-for-molecular-dynamics-and-related-methods-in-drug-discovery
#4
Sergio Decherchi, Giovanni Bottegoni, Andrea Spitaleri, Walter Rocchia, Andrea Cavalli
In this paper, we introduce the BiKi Life Sciences suite. This software makes it easy for computational medicinal chemists to run ad hoc molecular dynamics protocols in a novel and task-oriented environment; as a notebook, BiKi keeps memory of any activity together with dependencies among them. It offers unique accelerated protein-ligand binding/unbinding methods, and other useful tools to gain actionable knowledge from MD simulations and to simplify the drug discovery process.
January 17, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29335861/alterations-of-gefitinib-pharmacokinetics-by-co-administration-of-herbal-medications-in-rats
#5
Kwon-Yeon Weon, Min Gi Kim, Soyoung Shin, Tae Hwan Kim, Sang Hoon Joo, Eunsook Ma, Seok Won Jeong, Sun Dong Yoo, Yu Seok Youn, Beom Soo Shin
OBJECTIVE: To evaluate the potential pharmacokinetic interactions of the anticancer agent gefifitinib (Iressa®) and the oriental medications Guipi Decoction (, GPD, Guibi-tang in Korean) and Bawu Decoction (, BWD, Palmul-tang in Korean). METHODS: Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD (6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefifitinib (10 mg/kg) was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments...
January 15, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29330235/primary-care-physician-perspectives-about-antipsychotics-and-other-medications-for-symptoms-of-dementia
#6
J William Kerns, Jonathan D Winter, Katherine M Winter, Terry Boyd, Rebecca S Etz
BACKGROUND: Guidelines, policies, and warnings have been applied to reduce the use of medications for behavioral and psychological symptoms of dementia (BPSD). Because of rare dangerous side effects, antipsychotics have been singled out in these efforts. However, antipsychotics are still prescribed "off label" to hundreds of thousands of seniors residing in nursing homes and communities. Our objective was to evaluate how and why primary-care physicians (PCPs) employ nonpharmacologic strategies and drugs for BPSD...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29327121/recognition-of-association-between-blood-stasis-syndrome-and-traumatic-injury-among-doctors-of-korean-medicine-a-cross-sectional-observation-study
#7
Jeeyoun Jung, Mi Mi Ko, Ju Ah Lee, Myeong Soo Lee
OBJECTIVE: To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome (BSS) patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. METHODS: Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental Medicine between June 2014 and December 2014. Two independent doctors of Korean medicine (DKMs) determined the diagnosis of BSS or non-BSS based on the subjects' signs and symptoms...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29319720/depression-and-adherence-to-antiretroviral-treatment-in-hiv-positive-men-in-s%C3%A3-o-paulo-the-largest-city-in-south-america-social-and-psychological-implications
#8
Ricardo Pereira de Moraes, Jorge Casseb
OBJECTIVES: The aim of the present study was to investigate the prevalence of depression and adherence to antiretroviral treatment in two groups of individuals: men who have sex with men (MSM) and men who have sex with women (MSW). METHODS: Two hundred and sixteen participants (MSM=116; MSW=100) who visited the Clinics Hospital of the School of the Medicine of the University of São Paulo completed two independent surveys (the BECK Depression Inventory and an adherence self-declared questionnaire) to evaluate their depression status and adherence to antiretroviral treatment, respectively...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319647/transition-to-critical-care-practice-within-an-academic-service-partnership-a-case-report-of-the-first-3-years-of-clinical-immersion-in-trauma-burn-and-neuroscience-critical-care
#9
Esther Bay, Andrea Sherzer, Emily Darnbrook
In response to regulators of nursing education and the Institute of Medicine, an academic-service partnership was formed between a research-intensive school of nursing and a tertiary health care facility. In that partnership, clinical experiences occurred mostly within 1 organization. This case report showcases the development, implementation, and revisions within our capstone immersion course, designed to ease the new graduates' transition into practice, including transitions to critical care nursing. Herein, we highlight our successes and challenges of implementing the clinical component within 2 critical care units focused on trauma and neurosurgical care of complex patients...
January 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29318893/cross-polarised-and-parallel-polarised-light-viewing-and-photography-for-examination-and-documentation-of-biological-materials-in-medicine-and-forensics
#10
Katharine L Hanlon
Cross-polarisation, with regard to visible light, is a process wherein two polarisers with perpendicular orientation to one another are used on the incident and reflected lights. Under cross-polarised light birefringent structures which are otherwise invisible become apparent. Cross-polarised light eliminates glare and specular highlights, allowing for an unobstructed view of subsurface pathology. Parallel-polarisation occurs when the polarisers are rotated to the same orientation. When cross- or parallel-polarisation is applied to photography, images can be generated which aid in visualisation of surface and subsurface elements...
January 10, 2018: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/29318817/-application-of-image-recognition-technology-in-census-of-national-traditional-chinese-medicine-resources
#11
Xiao-Bo Zhang, Xiao-Guang Ge, Yan Jin, Ting-Ting Shi, Hui Wang, Meng Li, Zhi-Xian Jing, Lan-Ping Guo, Lu-Qi Huang
With the development of computer and image processing technology, image recognition technology has been applied to the national medicine resources census work at all stages.Among them: ①In the preparatory work, in order to establish a unified library of traditional Chinese medicine resources, using text recognition technology based on paper materials, be the assistant in the digitalization of various categories related to Chinese medicine resources; to determine the representative area and plots of the survey from each census team, based on the satellite remote sensing image and vegetation map and other basic data, using remote sensing image classification and other technical methods to assist in determining the key investigation area...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29318326/-reimbursement-of-intensive-care-services-in-austria-use-of-the-lkf-system
#12
REVIEW
M Joannidis, S J Klein, P Metnitz, A Valentin
In Austria, the reimbursement of intensive care services is based on a Diagnosis-Related Groups (DRG) system which has been adapted to the Austrian framework conditions. Compared to Germany where economic considerations had led to personnel cuts, mandatory targets outlined in both the LKF ("Leistungsorientierte Krankenanstaltenfinanzierung", Performance-oriented Hospital Financing) and ÖSG ("Österreichischer Strukturplan Gesundheit", Austrian Health Care Structure Plan) plans ensure a high level of medical and intensive care...
January 9, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29314554/going-from-evidence-to-recommendations-can-grade-get-us-there
#13
Mathew Mercuri, Brian Baigrie, Ross E G Upshur
The evidence based medicine movement has championed the need for objective and transparent methods of clinical guideline development. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) framework was developed for that purpose. Central to this framework is criteria for assessing the quality of evidence from clinical studies and the impact that body of evidence should have on our confidence in the clinical effectiveness of a therapy under examination. Grades of Recommendation, Assessment, Development, and Evaluation has been adopted by a number of professional medical societies and organizations as a means for orienting the development of clinical guidelines...
January 5, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29310924/coverage-and-readability-of-information-resources-to-help-patients-understand-radiology-reports
#14
Teresa Martin-Carreras, Charles E Kahn
BACKGROUND: Radiology reports can be difficult for a layperson to understand. MedlinePlus, a patient-oriented reference from the National Library of Medicine, may offer limited coverage of radiology report concepts. RadLex provides an extensive radiology vocabulary but may be ill suited to help patients understand radiology reports. We compared MedlinePlus, RadLex, and the PORTER (Patient-Oriented Radiology Reporter) lay-language radiology glossary for their coverage of radiology reports and for the readability of their definitions...
December 28, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29309437/transitioning-from-general-pediatric-to-adult-oriented-inpatient-care-national-survey-of-us-children-s-hospitals
#15
Ryan J Coller, Sarah Ahrens, Mary L Ehlenbach, Kristin A Shadman, Paul J Chung, Debra Lotstein, Andrew LaRocque, Ann Sheehy
BACKGROUND: Hospital charges and lengths of stay may be greater when adults with chronic conditions are admitted to children's hospitals. Despite multiple efforts to improve pediatric-adult healthcare transitions, little guidance exists for transitioning inpatient care. OBJECTIVE: This study sought to characterize pediatricadult inpatient care transitions across general pediatric services at US children's hospitals. DESIGN, SETTING AND PARTICIPANTS: National survey of inpatient general pediatric service leaders at US children's hospitals from January 2016 to July 2016...
January 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29303569/enantioselective-regiodivergent-synthesis-of-chiral-pyrrolidines-with-two-quaternary-stereocenters-via-ligand-controlled-cop-per-i-catalyzed-asymmetric-1-3-dipolar-cycloadditions
#16
Shan Xu, Zhan-Ming Zhang, Bing Xu, Bing Liu, Yuanyuan Liu, Junliang Zhang
An unprecedented ligand-controlled regiodivergent Cu(I)/Ligand-catalyzed asymmetric intermolecular [3+2] cycloaddi-tion reaction of α-substituted iminoesters with β-fluoromethyl β,β-disubstituted enones was developed. This novel strat-egy provides an efficient method for the enantioselective regiodivergent synthesis of pyrrolidines bearing two adjacent quaternary stereocenters or two discrete quaternary stereocenters, opening up a new era for medicinal chemistry and diversity-oriented synthesis. DFT calculations showed that the P,N-ligand L2 acts as a pseudo-bidentate ligand...
January 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29299856/malononitrile-dimer-as-a-privileged-reactant-in-design-and-skeletal-diverse-synthesis-of-heterocyclic-motifs
#17
REVIEW
Ahmad Shaabani, Seyyed Emad Hooshmand
Malononitrile dimer as a precursor reactant has been extensively applied in the diversity-oriented synthesis of various heterocyclic motifs, bis-heterocyclic compounds, fused heterocycle derivatives, bicyclic bridged heterocyclic scaffolds, and highly substituted carbocyclic compounds. These remarkable products were synthesized via various types of reactions, such as cycloaddition, cyclocondensation, cascade/domino/tandem reactions along with multi-component reactions. In addition, the flexibility and high reactivity of malononitrile dimer as a multi-functional reagent and its potential to the preparation of novel beneficial scaffolds as well as biologically active molecules signify it as a suitable building block in total synthesis, medicinal chemistry, and dyes...
January 3, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29298708/case-study-of-a-user-driven-prosthetic-arm-design-bionic-hand-versus-customized-body-powered-technology-in-a-highly-demanding-work-environment
#18
Wolf Schweitzer, Michael J Thali, David Egger
BACKGROUND: Prosthetic arm research predominantly focuses on "bionic" but not body-powered arms. However, any research orientation along user needs requires sufficiently precise workplace specifications and sufficiently hard testing. Forensic medicine is a demanding environment, also physically, also for non-disabled people, on several dimensions (e.g., distances, weights, size, temperature, time). METHODS: As unilateral below elbow amputee user, the first author is in a unique position to provide direct comparison of a "bionic" myoelectric iLimb Revolution (Touch Bionics) and a customized body-powered arm which contains a number of new developments initiated or developed by the user: (1) quick lock steel wrist unit; (2) cable mount modification; (3) cast shape modeled shoulder anchor; (4) suspension with a soft double layer liner (Ohio Willowwood) and tube gauze (Molnlycke) combination...
January 3, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29294669/college-sexual-assault-and-campus-climate-for-sexual-and-gender-minority-undergraduate-students
#19
Robert W S Coulter, Susan R Rankin
Sexual- and gender-minority (e.g., lesbian, gay, bisexual, and transgender) undergraduate students are at greater risk for sexual assault victimization than their cisgender (i.e., nontransgender) heterosexual peers. However, few studies have examined how social environments affect sexual assault victimization among sexual- and gender-minority undergraduate students. Nevertheless, this research area was identified as a priority by the Institute of Medicine as well as President Barack Obama's White House Task Force to Protect Students From Sexual Assault...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288554/development-of-a-patient-decision-aid-for-syncope-in-the-emergency-department-the-synda-tool
#20
Marc A Probst, Erik P Hess, Maggie Breslin, Dominick L Frosch, Benjamin C Sun, Marie-Noelle Langan, Lynne D Richardson
OBJECTIVES: To develop a patient decision aid to promote shared decision-making for stable, alert patients who present to the emergency department (ED) with syncope. METHODS: Using input from patients, clinicians, and experts in the field of syncope, health care design, and shared decision-making, we created a prototype of a paper-based decision aid to engage patients in the disposition decision (admission vs. discharge) after an unremarkable ED evaluation for syncope...
December 30, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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