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https://www.readbyqxmd.com/read/28738499/aqueous-extract-of-codium-fragile-suppressed-inflammatory-responses-in-lipopolysaccharide-stimulated-raw264-7-cells-and-carrageenan-induced-rats
#1
Seul Ah Lee, Sung-Min Moon, Yun Hee Choi, Seul Hee Han, Bo-Ram Park, Mi Suk Choi, Jae-Sung Kim, Yong Hwan Kim, Do Kyung Kim, Chun Sung Kim
Codium fragile (Suringar) Hariot has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria and has been shown to have various biological effects. In this study, we evaluated the anti-inflammatory effects of aqueous extract of C. fragile (AECF) using in vitro and in vivo models. Nitric oxide (NO), prostaglandin E2 (PGE2), inflammatory-related mRNAs, and proteins were determined using the Griess assay, enzyme-linked immunosorbent assay (ELISA), reverse transcription-polymerase chain reaction (RT-PCR), and western blotting, respectively...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28734017/evaluation-of-the-impact-of-strain-correction-on-the-orientation-of-cardiac-diffusion-tensors-with-in-vivo-and-ex-vivo-porcine-hearts
#2
Pedro F Ferreira, Sonia Nielles-Vallespin, Andrew D Scott, Ranil de Silva, Philip J Kilner, Daniel B Ennis, Daniel A Auger, Jonathan D Suever, Xiaodong Zhong, Bruce S Spottiswoode, Dudley J Pennell, Andrew E Arai, David N Firmin
PURPOSE: To evaluate the importance of strain-correcting stimulated echo acquisition mode echo-planar imaging cardiac diffusion tensor imaging. METHODS: Healthy pigs (n = 11) were successfully scanned with a 3D cine displacement-encoded imaging with stimulated echoes and a monopolar-stimulated echo-planar imaging diffusion tensor imaging sequence at 3 T during diastasis, peak systole, and strain sweet spots in a midventricular short-axis slice. The same diffusion tensor imaging sequence was repeated ex vivo after arresting the hearts in either a relaxed (KCl-induced) or contracted (BaCl2 -induced) state...
July 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28717517/knowledge-mapping-visualization-analysis-of-the-military-health-and-medicine-papers-published-in-the-web-of-science-over-the-past-10%C3%A2-years
#3
Xuan-Ming Zhang, Xuan Zhang, Xu Luo, Hai-Tao Guo, Li-Qun Zhang, Ji-Wei Guo
BACKGROUND: Military medicine is a research field that seeks to solve the medical problems that occur in modern war conditions based on public medicine theory. METHODS: We explore the main research topics of military health and medical research in the web of science™ core collection (WoSCC) from 2007 to 2016, and the goal of this work is to serve as a reference for orientation and development in military health and medicine. Based on CiteSpace III, a reference co-citation analysis is performed for 7921 papers published in the WoSCC from 2007 to 2016...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28704444/maternal-inheritance-of-deltamethrin-resistance-in-the-salmon-louse-lepeophtheirus-salmonis-kr%C3%A3-yer-is-associated-with-unique-mtdna-haplotypes
#4
Greta Carmona-Antoñanzas, Michaël Bekaert, Joseph L Humble, Sally Boyd, William Roy, David I Bassett, Ross D Houston, Karim Gharbi, James E Bron, Armin Sturm
Parasitic infections by the salmon louse, Lepeophtheirus salmonis (Krøyer), cause huge economic damage in salmon farming in the northern hemisphere, with combined treatment costs and production losses in 2014 having been estimated at US$ 350 million for Norway (annual production 1.25 million tonnes). The control of L. salmonis relies significantly on medicinal treatments, supplemented by non-pharmacological approaches. However, efficacy losses have been reported for several delousing agents, including the pyrethroid deltamethrin...
2017: PloS One
https://www.readbyqxmd.com/read/28703078/chrysophanol-suppresses-pro-inflammatory-response-in-microglia-via-regulation-of-drp1-dependent-mitochondrial-fission
#5
Unbin Chae, Ju-Sik Min, Hanna Lee, Kyung-Sik Song, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee
OBJECTIVES: Chrysophanol, also called chrysophanic acid, is a natural anthraquinone compound found in Rheum palmatum. R. palmatum has been used in oriental medicine in ancient East Asia. Microglial cells represent not only the forefront immune defense in the central nervous system but also the most reactive sensors to various threats. However, activated microglia can exert neurotoxic effects via excessive production of cytotoxic molecules and proinflammatory cytokines. Therefore, modulation of microglial cell activation is important for maintaining neuronal function...
July 13, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28701105/the-use-of-evidence-during-group-meetings-of-dutch-general-practitioners
#6
Bastiaan P H Ter Brugge, Marie-Louise E L Bartelink, Roger A M J Damoiseaux, Esther de Groot
BACKGROUND AND OBJECTIVES: For Evidence Based Medicine (EBM) learning journal clubs are recommended, but these are not common practice. How participants discuss and learn about applying evidence in other group meetings is unknown. We examined different types of group meetings and explored the use of, and discussions about, clinical research evidence. METHODS: A mixed-methods study design was adopted. After distribution and analysis of a questionnaire about types of group meetings, interviews were conducted to better understand the most frequently occurring type...
July 12, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28700248/comparative-benefits-and-harms-of-complementary-and-alternative-medicine-therapies-for-initial-treatment-of-major-depressive-disorder-systematic-review-and-meta-analysis
#7
Gary N Asher, Gerald Gartlehner, Bradley N Gaynes, Halle R Amick, Catherine Forneris, Laura C Morgan, Emmanuel Coker-Schwimmer, Erin Boland, Linda J Lux, Susan Gaylord, Carla Bann, Christiane Barbara Pierl, Kathleen N Lohr
OBJECTIVES: To report the comparative benefits and harms of exercise and complementary and alternative medicine (CAM) treatments with second-generation antidepressants (SGA) for major depressive disorder (MDD). DESIGN: Systematic review and meta-analysis. SETTINGS: Outpatient clinics. SUBJECTS: Adults, aged 18 years and older, with MDD receiving an initial treatment attempt with SGA. INTERVENTIONS: Any CAM or exercise intervention compared with an SGA...
July 12, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28695561/medical-challenges-at-the-end-of-the-first-ten-decades-of-life
#8
Thomas Münzer
Demographic changes worldwide challenge the healthcare system. Advanced age is associated with a number of biological alterations that, together with concomitant comorbidities, increase the risk for functional decline by inducing functional disintegration. In this concept frailty and sarcopenia play an important role. Consequently the preservation of muscle mass and function are prominent targets of medicine in old age. In order to professionally care for persons in their last years of life several other factors influencing medical decisions regarding diagnostic and treatments are important...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28693482/the-development-and-feasibility-of-a-personal-health-optimization-system-for-people-with-bipolar-disorder
#9
Øystein Eiring, Kari Nytrøen, Simone Kienlin, Soudabeh Khodambashi, Magne Nylenna
BACKGROUND: People with bipolar disorder often experience ill health and have considerably reduced life expectancies. Suboptimal treatment is common and includes a lack of effective medicines, overtreatment, and non-adherence to medical interventions and lifestyle measures. E- and m-health applications support patients in optimizing their treatment but often exhibit conceptual and technical shortcomings. The objective of this work was to develop and test the usability of a system targeting suboptimal treatment and compare the service to other genres and strategies...
July 10, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28691439/awareness-and-willingness-to-use-hiv-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#10
Siyan Yi, Sovannary Tuot, Grace W Mwai, Chanrith Ngin, Kolab Chhim, Khoundyla Pal, Ewemade Igbinedion, Paula Holland, Sok Chamreun Choub, Gitau Mburu
INTRODUCTION: To facilitate provision of pre-exposure prophylaxis (PrEP) in low- and middle-income countries (LMIC), a better understanding of potential demand and user preferences is required. This review assessed awareness and willingness to use oral PrEP among men who have sex with men (MSM) in LMIC. METHODS: Electronic literature search of Cochrane library, Embase, PubMed, PsychINFO, CINHAL, Web of Science, and Google Scholar was conducted between July and September 2016...
June 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28686785/liquid-crystal-phantom-for-validation-of-microscopic-diffusion-anisotropy-measurements-on-clinical-mri-systems
#11
Markus Nilsson, Johan Larsson, Dan Lundberg, Filip Szczepankiewicz, Thomas Witzel, Carl-Fredrik Westin, Karin Bryskhe, Daniel Topgaard
PURPOSE: To develop a phantom for validating MRI pulse sequences and data processing methods to quantify microscopic diffusion anisotropy in the human brain. METHODS: Using a liquid crystal consisting of water, detergent, and hydrocarbon, we designed a 0.5-L spherical phantom showing the theoretically highest possible degree of microscopic anisotropy. Data were acquired on the Connectome scanner using echo-planar imaging signal readout and diffusion encoding with axisymmetric b-tensors of varying magnitude, anisotropy, and orientation...
July 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28684299/cyperus-amuricus-induces-g1-arrest-and-apoptosis-through-endoplasmic-reticulum-stress-and-mitochondrial-signaling-in-human-hepatocellular-carcinoma-hep3b-cells
#12
Hai Ha Thi Pham, Yeong-Ae Seong, Daniel Ngabire, Chul-Woong Oh, Gun-Do Kim
ETHNOPHARMACOLOGY RELEVANCE: Cyperus amuricus (C. amuricus), belongs to the family Cyperaceae, was used to exert wound healing, diuretic, astringent and other intestinal problems in oriental medicine. However, only a few studies have reported its anticancer activities. AIM OF THE STUDY: In this study, we determined the activity of C. amuricus on ER stress-induced cell death and G1 cell cycle arrest in human hepatocellular carcinoma (HCC) Hep3B cells. MATERIALS AND METHODS: The in vitro cell proliferation assay of C...
July 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28683799/mindfulness-and-compassion-oriented-practices-at-work-reduce-distress-and-enhance-self-care-of-palliative-care-teams-a-mixed-method-evaluation-of-an-on-the-job-program
#13
Claudia L Orellana-Rios, Lukas Radbruch, Martina Kern, Yesche U Regel, Andreas Anton, Shane Sinclair, Stefan Schmidt
BACKGROUND: Maintaining a sense of self-care while providing patient centered care, can be difficult for practitioners in palliative medicine. We aimed to pilot an "on the job" mindfulness and compassion-oriented meditation training for interdisciplinary teams designed to reduce distress, foster resilience and strengthen a prosocial motivation in the clinical encounter. METHODS: Our objective was to explore the feasibility and effectiveness of this newly developed training...
July 6, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28676467/the-rules-of-engagement-perspectives-on-secure-messaging-from-experienced-ambulatory-patient-portal-users
#14
Cynthia J Sieck, Jennifer L Hefner, Jeanette Schnierle, Hannah Florian, Aradhna Agarwal, Kristen Rundell, Ann Scheck McAlearney
BACKGROUND: Patient portals have shown promise in engaging individuals in self-management of chronic conditions by allowing patients to input and track health information and exchange secure electronic messages with their providers. Past studies have identified patient barriers to portal use including usability issues, low health literacy, and concerns about loss of personal contact as well as provider concerns such as increased time spent responding to messages. However, to date, studies of both patient and provider perspectives on portal use have focused on the pre-implementation or initial implementation phases and do not consider how these issues may change as patients and providers gain greater experience with portals...
July 4, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28671393/top-20-research-studies-of-2016-for-primary-care-physicians
#15
Mark H Ebell, Roland Grad
This article summarizes the top 20 original research studies and four practice guidelines of 2016, based on regular literature surveillance and as selected by members of the Canadian Medical Association. The studies, known as POEMs (patient-oriented evidence that matters), were rated highly because of their relevance, validity, and potential to change practice. Key hypertension treatment findings include reduced mortality (a benefit not demonstrated in lower-risk persons or persons with diabetes mellitus) but also an increase in harms with a more aggressive blood pressure target in high-risk persons with hypertension and without diabetes...
May 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28669721/initial-investigation-of-individual-and-combined-annulus-fibrosus-and-nucleus-pulposus-repair-ex-vivo
#16
Stephen R Sloan, Devis Galesso, Cynthia Secchieri, Connor Berlin, Roger Hartl, Lawrence J Bonassar
Novel tissue engineered and biomaterial approaches to treat intervertebral disc (IVD) degeneration focus on single aspects of the progressive disease and hence are insufficient repair strategies. In this study, annulus fibrosus (AF) and nucleus pulposus (NP) biomaterial repair strategies were used individually and combined to treat IVD degeneration modeled in ex vivo rat-tail motion segments by annulotomy and nucleotomy. An injectable riboflavin cross-linked high-density collagen gel patched defects in the AF, while NP repair consisted of injections of a modified hyaluronic acid (HA) hydrogel...
June 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28665921/rhododendrin-inhibits-toll-like-receptor-7-mediated-psoriasis-like-skin-inflammation-in-mice
#17
Yoon-Jae Jeon, Shyam Kishor Sah, Hee Seung Yang, Ji Hae Lee, Jongheon Shin, Tae-Yoon Kim
Many active compounds present in Rhododendron brachycarpum have been used in traditional Oriental medicine for the treatment of various skin diseases. However, the precise mechanism of action of the compounds isolated from R. brachycarpum and their relevance as therapeutics for the treatment of psoriasis remain elusive. In this study, we report that rhododendrin isolated from R. brachycarpum strongly inhibits imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. We showed that topical treatment with rhododendrin reduces IMQ-induced skin hyperplasia, inflammatory mononuclear cell infiltration and the expression of pro-inflammatory mediators in mouse skin...
June 30, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28661695/treatment-of-chemotherapy-induced-peripheral-neuropathy-in-integrative-oncology-a-survey-of-acupuncture-and-oriental-medicine-practitioners
#18
Zhaoxue Lu, Jennifer Moody, Benjamin L Marx, Tracy Hammerstrom
OBJECTIVES: Complementary and alternative medicine is increasingly integrated into cancer care. We sought detail on the treatment of chemotherapy-induced peripheral neuropathy (CIPN) with acupuncture and oriental medicine (AOM) by surveying practitioners at integrative oncology (IO) sites across the United States. DESIGN: Online survey of licensed acupuncturists. SETTING/LOCATION: IO sites in the United States. SUBJECTS: Fifteen licensed acupuncturists who completed the survey between February 2014 and June 2014...
June 29, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28661368/conference-report-the-2016-olten-meeting-at-the-basel-life-science-week
#19
Elsbeth Heinzelmann
"This 'telephone' has too many shortcomings to be seriously considered as a means of communication. The device is inherently of no value to us." This was an internal memo written by Western Union in 1876. That's right. Without efficient knowledge sharing and technology transfer, even the best scientific development may prove to be a damp squib for a long time. The Basel Life Science Week was created in order to promote scientific and economic exchange and pave the way for innovative ideas. That's why NTN Swiss Biotech has moved its traditional 'Olten Meeting' to the Basel Life Science Week...
December 21, 2016: Chimia
https://www.readbyqxmd.com/read/28649444/reverse-engineering-highlights-potential-principles-of-large-gene-regulatory-network-design-and-learning
#20
Clément Carré, André Mas, Gabriel Krouk
Inferring transcriptional gene regulatory networks from transcriptomic datasets is a key challenge of systems biology, with potential impacts ranging from medicine to agronomy. There are several techniques used presently to experimentally assay transcription factors to target relationships, defining important information about real gene regulatory networks connections. These techniques include classical ChIP-seq, yeast one-hybrid, or more recently, DAP-seq or target technologies. These techniques are usually used to validate algorithm predictions...
2017: NPJ Systems Biology and Applications
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