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Antidepressant-induced sexual dysfunction

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https://www.readbyqxmd.com/read/27701952/add-on-mirtazapine-improves-orgasmic-functioning-in-patients-with-schizophrenia-treated-with-first-generation-antipsychotics
#1
Viacheslav Terevnikov, Jan-Henry Stenberg, Jari Tiihonen, Mark Burkin, Grigori Joffe
AIM: Sexual dysfunction, common in schizophrenia, may be further exaggerated by antipsychotics, especially those of First Generation (FGAs), and antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRs). Mirtazapine, an antidepressant characterized by its different action mechanism compared with that of the majority of other antidepressants, may improve SSRI-induced sexual dysfunction in patients with depression. It is unknown, however, whether mirtazapine improves sexual functioning in schizophrenia...
October 5, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27652223/is-there-a-place-for-surgical-treatment-of-premature-ejaculation
#2
REVIEW
Du Geon Moon
Management of premature ejaculation (PE) has evolved tremandoulsy over the last 20 years. Selective serotonin reuptake inhibitor (SSRI) antidepressants and local anesthetics are the most and best studied treatments. This evidence has led to the establishment of an evidence-based definition of PE and the International Society for Sexual Medicine (ISSM) guidelines for the diagnosis and treatment of PE. The current treatment of choice for PE according to the ISSM guidelines is a centrally acting SSRI or peripherally acting topical anesthetics...
August 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27594188/antidepressant-induced-female-sexual-dysfunction
#3
REVIEW
Tierney Lorenz, Jordan Rullo, Stephanie Faubion
Because 1 in 6 women in the United States takes antidepressants and a substantial proportion of patients report some disturbance of sexual function while taking these medications, it is a near certainty that the practicing clinician will need to know how to assess and manage antidepressant-related female sexual dysfunction. Adverse sexual effects can be complex because there are several potentially overlapping etiologies, including sexual dysfunction associated with the underlying mood disorder. As such, careful assessment of sexual function at the premedication visit followed by monitoring at subsequent visits is critical...
September 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27541930/modulation-of-dopaminergic-pathways-to-treat-erectile-dysfunction
#4
Ulf Simonsen, Simon Comerma-Steffensen, Karl-Erik Andersson
The currently recommended first-line treatments of erectile dysfunction, phosphodiesterase type 5 inhibitors (PDE5i), e.g. sildenafil, are efficacious in many patients with erectile dysfunction of vascular origin, but this therapy is insufficient in approximately 30-40% of men with erectile dysfunction where there is also a neuronal affection. There is a demand of novel approaches to treat the condition. We review the possibility of modulating the dopaminergic pathways to improve erectile function. Dopamine D1 (D1 , D5 )-and D2 (D2 -D4 )-like receptors in the paraventricular area, the medial preoptic area, the spinal cord, and in the erectile tissue are involved in erection, and several agonists developed for treatment of Parkinson's disease are associated with increased libido...
August 19, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27514298/sexual-dysfunction-due-to-psychotropic-medications
#5
REVIEW
Anita H Clayton, Andrew R Alkis, Nishant B Parikh, Jennifer G Votta
Sexual functioning is important to assess in patients with psychiatric illness as both the condition and associated treatment may contribute to sexual dysfunction (SD). Antidepressant medications, mood stabilizers, antipsychotics, and antianxiety agents may be associated with SD related to drug mechanism of action. Sexual adverse effects may be related to genetic risk factors, impact on neurotransmitters and hormones, and psychological elements. Effective strategies to manage medication-induced sexual dysfunction are initial choice of a drug unlikely to cause SD, switching to a different medication, and adding an antidote to reverse SD...
September 2016: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/27423475/-antidepressant-and-tolerance-determinants-and-management-of-major-side-effects
#6
D J David, D Gourion
Antidepressant therapy aims to reach remission of depressive symptoms while reducing the complications and risks of relapse. Even though they have proven their efficacy, it takes several weeks for antidepressants to demonstrate full effectiveness, and adverse effects occur more quickly or (quicker) which can be a source of poor compliance. This latest aspect often leads to dose reduction and/or change of molecule that have the effect of delaying remission. This review attempts to present, from the pharmacological properties of the major classes of antidepressants (monoamine oxidase inhibitor [MAOI], tricyclic antidepressants [TCA], selective serotonin reuptake inhibitor [SSRI] and serotonin and noradrenaline reuptake inhibitor [SNRI]), to the pharmacological mechanisms involved in adverse effects by focusing on sexual dysfunction, nausea/vomiting, and weight changes and sleep disruption...
July 14, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27392437/fluoxetine-and-the-mitochondria-a-review-of-the-toxicological-aspects
#7
Marcos Roberto de Oliveira
Fluoxetine (a selective serotonin reuptake inhibitor (SSRI)) is used as an antidepressant by modulating the levels of serotonin in the synaptic cleft. Nevertheless, fluoxetine also induces undesirable effects, such as anxiety, sexual dysfunction, sleep disturbances, and gastrointestinal impairments. Fluoxetine has been viewed as an agent that may interfere with cell fate by triggering apoptosis. On the other hand, fluoxetine intake has been associated with increased cancer risk. Nonetheless, data remain contradictory and no conclusions were taken...
September 6, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27149715/-sexual-dysfunction-among-patients-with-psychiatric-disorders
#8
REVIEW
Lorenzo Soldati
Scientific literature shows that sexual dysfunction is more common in patients suffering from psychiatric illness as opposed to the general population. It also shows that the prevalence of sexual dysfunction is underestimated by professionals, partly because patients rarely talk spontaneously about their dysfunctions. However, sexual dysfunction has an impact on patients' mental health. Furthermore, some psychotropic medication, antidepressants and antipsychotics in particular, can hinder sexual functioning and induce sexual dysfunction...
March 16, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26908119/-influence-of-drugs-on-urological-diseases
#9
P A Thürmann
A number of drugs prescribed for the treatment of various diseases can induce urological symptoms as side effects. Antihypertensive drugs (particularly alpha blockers) can result in stress incontinence, whereas selective serotonin reuptake inhibitors (SSRI) can cause urge incontinence and estrogen promotes both forms. A wide range of drugs with anticholinergic activity, among them neuroleptics, tricyclic antidepressants and certain drugs used in airway disorders are associated with urinary retention. Only very few drugs bear a relevant risk for urolithiasis, i...
March 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/26758283/differential-effects-of-vilazodone-versus-citalopram-and-paroxetine-on-sexual-behaviors-and-serotonin-transporter-and-receptors-in-male-rats
#10
Ronald S Oosting, Johnny S Chan, Berend Olivier, Pradeep Banerjee, Yong Kee Choi, Frank Tarazi
RATIONALE: Sexual side effects are commonly associated with selective serotonin reuptake inhibitor (SSRI) treatment. Some evidence suggest that activation of 5-HT1A receptors attenuates SSRI-induced sexual dysfunction. OBJECTIVE: This study in male rats compared the effects of vilazodone, an antidepressant with SSRI and 5-HT1A receptor partial agonist activity, with other prototypical SSRIs (citalopram and paroxetine) on sexual behaviors and 5-HT receptors (5-HT1A and 5-HT2A) and transporter (5-HTT) levels in select forebrain regions of the limbic system using quantitative autoradiography...
March 2016: Psychopharmacology
https://www.readbyqxmd.com/read/26274043/use-of-an-operant-paradigm-for-the-study-of-antidepressant-induced-sexual-dysfunction
#11
Lynda Uphouse, Jonathan Pinkston, Duane Baade, Christian Solano, Bless Onaiwu
These studies were designed to develop a paradigm for the detection of antidepressant-induced sexual dysfunction in female rats. Ovariectomized, Fischer rats were conditioned to nose poke to open a guillotine door to gain access to a sexually active male. To develop the procedure, we examined the acquisition and stability of the response with a 15-s fixed interval, compared rats treated with 10 μg estradiol benzoate and 500 μg progesterone with those that received only estradiol benzoate, and carried out a preliminary analysis of the effects of 5, 10, and 15 mg/kg fluoxetine...
October 2015: Behavioural Pharmacology
https://www.readbyqxmd.com/read/25954318/a-double-blind-placebo-controlled-trial-of-maca-root-as-treatment-for-antidepressant-induced-sexual-dysfunction-in-women
#12
Christina M Dording, Pamela J Schettler, Elizabeth D Dalton, Susannah R Parkin, Rosemary S W Walker, Kara B Fehling, Maurizio Fava, David Mischoulon
Objective. We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction (AISD) in women. Method. We conducted a 12-week, double-blind, placebo-controlled trial of maca root (3.0 g/day) in 45 female outpatients (mean age of 41.5 ± 12.5 years) with SSRI/SNRI-induced sexual dysfunction whose depression remitted. Endpoints were improvement in sexual functioning as per the Arizona Sexual Experience Scale (ASEX) and the Massachusetts General Hospital Sexual Function Questionnaire (MGH-SFQ)...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/25467077/antidepressant-induced-sexual-dysfunction-during-treatment-with-fluoxetine-sertraline-and-trazodone-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Habibolah Khazaie, Leeba Rezaie, Nastarn Rezaei Payam, Farid Najafi
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are common treatments for patients with major depressive disorder (MDD). However, adverse effects of SSRIs on sexual function are common in the treatment of patients with MDD. There is a discrepancy in the reported frequency of SSRI-induced sexual dysfunction. On the other hand, there is also less evidence about sexual dysfunction with serotonin receptor antagonists and reuptake inhibitors (SARIs). Therefore, we aimed to assess sexual dysfunction in MDD patients who received fluoxetine, sertraline and trazodone...
January 2015: General Hospital Psychiatry
https://www.readbyqxmd.com/read/25335956/management-of-antidepressant-induced-sexual-dysfunction
#14
REVIEW
Nicholas A Keks, Judy Hope, Christine Culhane
OBJECTIVE: Antidepressant-induced sexual dysfunction is a common, troublesome complication of antidepressant treatment that patients often fail to report, which can have major consequences, including non-adherence to treatment with resultant relapse of depressive illness. The aim of this paper is to review the extent, causation and evidence-based management of antidepressant-induced sexual dysfunction to inform clinical practice. CONCLUSIONS: The preponderance of evidence suggests that antidepressant s can be divided into high risk (selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors) and low risk (agomelatine, bupropion, moclobemide and reboxetine) categories with regard to propensity for antidepressant-induced sexual dysfunction, although there is disagreement, particularly about mirtazapine, and methodological issues militate against definitive findings...
December 2014: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/24754044/exercise-improves-sexual-function-in-women-taking-antidepressants-results-from-a-randomized-crossover-trial
#15
RANDOMIZED CONTROLLED TRIAL
Tierney Ahrold Lorenz, Cindy May Meston
BACKGROUND: In laboratory studies, exercise immediately before sexual stimuli improved sexual arousal of women taking antidepressants [1]. We evaluated if exercise improves sexual desire, orgasm, and global sexual functioning in women experiencing antidepressant-induced sexual side effects. METHODS: Fifty-two women who were reporting antidepressant sexual side effects were followed for 3 weeks of sexual activity only. They were randomized to complete either three weeks of exercise immediately before sexual activity (3×/week) or 3 weeks of exercise separate from sexual activity (3×/week)...
March 2014: Depression and Anxiety
https://www.readbyqxmd.com/read/24239785/antidepressant-induced-sexual-dysfunction-in-men
#16
REVIEW
Robert Taylor Segraves, Richard Balon
Most of the available antidepressant medications, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and dual noradrenergic/serotonergic reuptake inhibitors have been reported to be associated with sexual dysfunction in both sexes. This manuscript reviews evidence concerning the relative incidence of treatment emergent sexual dysfunction in men being treated with antidepressant drugs. Both double-blind controlled trials and large clinical series report a high incidence of sexual dysfunction, especially ejaculatory delay, with serotonergic drugs...
June 2014: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/24128918/sexual-side-effects-of-serotonergic-antidepressants-mediated-by-inhibition-of-serotonin-on-central-dopamine-release
#17
REVIEW
Elisabeth Y Bijlsma, Johnny S W Chan, Berend Olivier, Jan G Veening, Mark J Millan, Marcel D Waldinger, Ronald S Oosting
Antidepressant-induced sexual dysfunction adversely affects the quality of life of antidepressant users and reduces compliance with treatment. Animal models provide an instructive approach for examining potential sexual side effects of novel drugs. This review discusses the stability and reproducibility of our standardized test procedure that assesses the acute, subchronic and chronic effects of psychoactive compounds in a 30 minute mating test. In addition, we present an overview of the effects of several different (putative) antidepressants on male rat sexual behavior, as tested in our standardized test procedure...
June 2014: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/23728950/reports-of-sexual-disorders-related-to-serotonin-reuptake-inhibitors-in-the-french-pharmacovigilance-database-an-example-of-underreporting
#18
Thierry Trenque, Géric Maura, Emmanuelle Herlem, Catherine Vallet, Elodie Sole, Pascal Auriche, Moustapha Drame
BACKGROUND: Depressive disorders and use of antidepressants are associated with adverse effects on sexual function. In pharmacoepidemiological studies, sexual disorders are reported by more than 50 % of patients taking serotonin reuptake inhibitors (SRIs). OBJECTIVE: The aim of this study was to determine the reporting rate of sexual disorders in association with SRIs, and to investigate the association between reported cases and the use of SRIs. METHODS: All cases of adverse drug reactions (ADRs) involving sexual disorders, spontaneously reported to the French Pharmacovigilance Database from 1 January 1985 to December 2009, were reviewed...
July 2013: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/23728643/strategies-for-managing-sexual-dysfunction-induced-by-antidepressant-medication
#19
REVIEW
Matthew J Taylor, Lisa Rudkin, Philippa Bullemor-Day, Jade Lubin, Christopher Chukwujekwu, Keith Hawton
BACKGROUND: Sexual dysfunction (including altered sexual desire, orgasmic and ejaculatory dysfunction, erectile and other problems) is a relatively common side effect of antidepressant medication. These sexual side effects may compromise a person's lifestyle and result in a lack of compliance with the prescribed antidepressant to the detriment of the person's mental health. A wide range of management strategies are possible to address this problem, including behavioural, psychological and pharmacological approaches...
May 31, 2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23376864/the-effect-of-sildenafil-on-quality-of-life
#20
RANDOMIZED CONTROLLED TRIAL
Christina M Dording, Rachel A LaRocca, Katherine A Hails, Ottavio V Vitolo, Stephen R Wisniewski, Goundappa K Balasubramani, Madhukar Trivedi, Maurizio Fava, David Mischoulon
BACKGROUND: Antidepressant-induced sexual dysfunction affects approximately 50% of patients taking antidepressants. Previous research has explored sildenafil's effectiveness in treating various forms of erectile dysfunction, but there is no research supporting sildenafil's use for improving the quality of life for patients with sexual dysfunction linked to antidepressant use. The authors of this article aimed to assess the improvements in quality of life in patients taking sildenafil to treat antidepressant-induced sexual dysfunction...
February 2013: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
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