keyword
MENU ▼
Read by QxMD icon Read
search

Lacunar infarct

keyword
https://www.readbyqxmd.com/read/28899518/relationship-between-obstructive-sleep-apnea-and-neuroimaging-signatures-of-cerebral-small-vessel-disease-in-community-dwelling-older-adults-the-atahualpa-project
#1
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Pablo R Castillo
BACKGROUND/OBJECTIVES: Evidence of a relationship between obstructive sleep apnea (OSA) and neuroimaging signatures of cerebral small vessel disease (SVD) is limited. The present study aimed to evaluate this association in older adults living in rural Ecuador, where small vessel disease is a major pathogenetic mechanism underlying stroke. METHODS: A representative random sample of Atahualpa residents aged ≥60 years enrolled in the Atahualpa Project neuroimaging substudy underwent a single-night diagnostic polysomnography...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28888808/association-of-high-density-lipoprotein-cholesterol-concentration-with-different-types-of-stroke-and-coronary-heart-disease-the-japan-public-health-center-based-prospective-jphc-study
#2
Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane
BACKGROUND AND AIMS: Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations. METHODS: A prospective study was conducted among 30,736 individuals aged 40-69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors...
September 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28870596/common-and-specific-risk-factors-for-ischemic-stroke-in-elderly-differences-based-on-type-of-ischemic-stroke-and-aging
#3
Sayato Fukui, Ryoko Imazeki, Yu Amano, Yousuke Kudo, Kazumitsu Amari, Masahiro Yamamoto, Kikue Todoroki, Yoshimori Ikeya, Takashi Okazaki, Noriharu Yanagimachi, Toru Shizuma, Naoto Fukuyama, Ken Johkura, Hidezo Mori
BACKGROUND: The risk factors among the types of ischemic stroke (atherothrombotic cerebral infarction: ATI, cardio-embolic infarction: CEI, lacunar infarction: LI) in aged stroke patients have rarely been compared to each other. METHODS: We compared the clinical parameters of 300 elderly patients with ischemic stroke, age 65-98years, to 100 age-matched control patients. RESULTS: Comparison by parametric test and logistic regression analysis between all 300 and 100 control patients showed higher systolic and diastolic blood pressures (p<0...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28870545/arterial-stiffness-and-cognitive-impairment
#4
REVIEW
Xiaoxuan Li, Peiyuan Lyu, Yanyan Ren, Jin An, Yanhong Dong
BACKGROUND: Arterial stiffness is one of the earliest indicators of changes in vascular wall structure and function and may be assessed using various indicators, such as pulse-wave velocity (PWV), the cardio-ankle vascular index (CAVI), the ankle-brachial index (ABI), pulse pressure (PP), the augmentation index (AI), flow-mediated dilation (FMD), carotid intima media thickness (IMT) and arterial stiffness index-β. Arterial stiffness is generally considered an independent predictor of cardiovascular and cerebrovascular diseases...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28869136/basilar-artery-dolichoectasia-prevalence-and-correlates-with-markers-of-cerebral-small-vessel-disease-in-community-dwelling-older-adults
#5
Oscar H Del Brutto, Robertino M Mera, Victor J Del Brutto, Aldo F Costa, Mauricio Zambrano, James Brorson
BACKGROUND: Basilar artery (BA) dolichoectasia has been associated with cerebral small vessel disease (SVD). However, studies have focused on stroke patients, and results cannot be extrapolated to the population at large. In this study, we aimed to assess prevalence of BA dolichoectasia and its association with SVD in community-dwelling older adults living in rural Ecuador. METHODS: Atahualpa residents aged ≥60 years underwent brain magnetic resonance imaging and magnetic resonance angiography of intracranial vessels...
August 28, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28869134/isolated-ino-as-a-presentation-of-midbrain-paramedian-area-lacunar-infarction-in-patients-with-diabetes
#6
Yun Zhang, Lili Wang, Maolin He
The clinical features and pathogenesis of the pure midbrain infarction need to be described. Of 4257 stroke patients who were on the stroke registry between January 2000 and December 2015, 25 patients with pure midbrain infarctions, as demonstrated on diffusion-weighted magnetic resonance imaging, were enrolled. We analyzed the clinical features, MRI findings, and etiologic mechanisms of the infarctions. According to the distribution of each penetrating artery of the midbrain, we classified all the infarctions into paramedian (PM) area (13 patients), lateral area (10 patients), and PM and lateral areas (2 patients)...
August 28, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28867524/severity-of-white-matter-lesions-correlates-with-subcortical-diffusion-weighted-imaging-abnormalities-and-predicts-stroke-risk
#7
Hui Fang, Lu Zhao, Lulu Pei, Bo Song, Yuan Gao, Kai Liu, Yafang Xu, Yusheng Li, Jun Wu, Yuming Xu
BACKGROUND AND PURPOSE: The severity of white matter lesions (WMLs) has been strongly linked to small-vessel diseases or lacunar infarction. The present study aimed to investigate the correlation between severity of WMLs and distribution of diffusion-weighted imaging (DWI) hyperintensities, and to explore whether the severity of WMLs is an independent neuroimaging predictor of stroke risk after transient symptoms with infarction (TSI). METHODS: We evaluated the presence and severity of WMLs on fluid-attenuated inversion recovery sequences using the age-related white matter changes scale and the location and size of hyperintensities on DWI sequences, respectively, in a prospective cohort study of TSI patients...
August 31, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28861035/molecular-disorganization-of-axons-adjacent-to-human-cortical-microinfarcts
#8
Hamza Coban, Spencer Tung, Bryan Yoo, Harry V Vinters, Jason D Hinman
Cortical microinfarcts (CMIs) are microscopically identified wedge-shaped ischemic lesions that occur at or near the cortical surface and result from occlusion of penetrating arterioles. These microscopic lesions can be observed with high-resolution magnetic resonance imaging in aging brains and in patients with cerebrovascular disease. Recent studies have suggested that strategically located microinfarcts strongly correlate with cognitive deficits, which can contribute to Alzheimer's disease as well as other forms of dementia...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28833961/clinical-relevance-of-abnormal-neuroimaging-findings-and-long-term-risk-of-stroke-recurrence
#9
K-W Nam, H-M Kwon, J-S Lim, M-K Han, Y-S Lee
BACKGROUND AND PURPOSE: Previous studies have revealed that the predictors of short- and long-term stroke recurrence are different. We designed a comprehensive stroke recurrence (CSR) model, composed of demographic, clinical and radiological findings, to predict long-term ischaemic stroke recurrences. METHODS: We retrospectively collected the derivation cohort from consecutive patients with first-ever ischaemic stroke within 7 days of symptom onset. Univariate and multivariable Cox regression analysis were used to evaluate the association between 2-year recurrence and demographic, clinical and neuroradiological factors...
August 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28827244/the-relationship-between-ambulatory-blood-pressure-variability-and-enlarged-perivascular-spaces-a-cross-sectional-study
#10
Shuna Yang, Wei Qin, Lei Yang, Huimin Fan, Yue Li, Jiangmei Yin, Wenli Hu
OBJECTIVES: Recent studies reported that 24-hour ambulatory blood pressure variability (ABPV) was associated with lacunar infarction and white matter hyperintensities (WMH). However, the relationship between ABPV and enlarged perivascular spaces (EPVS) has not been investigated. Thus, our study aimed to investigate whether ABPV is associated with EPVS by 24-hour ambulatory blood pressure monitoring (ABPM). DESIGN: We conducted this study as a cross-sectional study...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28822176/-cerebral-microangiopathy-of-diabetes
#11
REVIEW
Yuan Li, Ke-Wu Zeng, Xue-Mei Wang
Diabetes mellitus, a kind of chronic metabolic disease, has become one of major threats to human health with an increasing incidence. As a basic pathology of chronic complications related to diabetes mellitus, cerebral microangiopathy is mainly found in patients with Alzheimer's disease and lacunar infarction, and becomes one of the main reasons of death and disability in diabetic patients. The pathogenesis of cerebral microangiopathy is complicated, involving such signal pathways as metabolic abnormalities of polyol, saccharification hyperactivity, oxidative stress, abnormal transport of amyloid-β across blood-brain barrier and protein kinase C activation...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28820279/mri-and-clinical-characteristics-of-suspected-cerebrovascular-accident-in-nine-cats
#12
Danielle E Whittaker, Randi Drees, Elsa Beltran
Objectives Cerebrovascular accidents (CVAs) are infrequently reported in cats. To date, clinical characteristics, including lesion localisation and MRI findings, have only been reported in two cats. The aim of the current study is to document MRI findings in cats presenting with CVAs over an 11 year period. Cases were reviewed according to initial clinical presentation, subsequent physical and neurological findings, predisposing systemic disease and short- and long-term (when available) outcome with a view to identifying any typical pattern in disease occurrence...
August 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28810566/correlation-analysis-between-the-ldl-c-in-serum-and-the-onset-of-transient-ischemic-attack-caused-by-csvd
#13
Yaqi Chen, Mei Hu, Hongying Gong
The aim of this study was to investigate the correlation between the low-density lipoprotein cholesterol (LDL-C) in serum and the onset of transient ischemic attack caused by cerebral small vascular disease (CSVD). Between September 2012 and September 2015, 249 patients who were diagnosed as CSVD were randomly enrolled in this study. According to MRI results, patients were divided into the patient and control groups. In the patient group, the patients were further subdivided into the white matter lesion (WML) group (n=86) and lacunar infarction (LI) group (n=53)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28793877/subarachnoid-small-vein-occlusion-due-to-inflammatory-fibrosis-a-possible-mechanism-for-cerebellar-infarction-in-cryptococcal-meningoencephalitis-a-case-report
#14
Yoshiteru Shimoda, Satoru Ohtomo, Hiroaki Arai, Takashi Ohtoh, Teiji Tominaga
BACKGROUND: Cryptococcal meningoencephalitis (CM) causes cerebral infarction, typically, lacunar infarction in the basal ganglia. However, massive cerebral infarction leading to death is rare and its pathophysiology is unclear. We report a case of CM causing massive cerebellar infarction, which led to cerebral herniation and death. CASE PRESENTATION: A 56-year-old man who suffered from dizziness and gait disturbance for one month was admitted to our hospital and subsequently diagnosed with a cerebellar infarction...
August 9, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28782182/heterozygous-mutations-of-htra1-gene-in-patients-with-familial-cerebral-small-vessel-disease
#15
Ilaria Di Donato, Silvia Bianchi, Gian Nicola Gallus, Alfonso Cerase, Ilaria Taglia, Francesca Pescini, Serena Nannucci, Carla Battisti, Domenico Inzitari, Leonardo Pantoni, Andrea Zini, Antonio Federico, Maria Teresa Dotti
AIMS: Cerebral small vessel disease (SVD) is the leading cause of vascular dementia. Although the most of cases are sporadic, familial monogenic causes have been identified in a growing minority of patients. CADASIL, due to mutations of NOTCH3 gene, is the most common genetic SVD, and CARASIL, linked to HTRA1 gene mutations, is a rare but well known autosomal recessive SVD. Recently, also heterozygous HTRA1 mutations have been described in patients with familial SVD. To detect a genetic cause of familial SVD, we performed mutational analysis of HTRA1 gene in a large cohort of Italian NOTCH3-negative patients...
September 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28781057/multiple-lacunar-infarcts-in-paroxysmal-nocturnal-hemoglobinuria
#16
Alex Tiburtino Meira, Gabriel Sampaio Froehner, André Petean Trindade, Silméia Garcia Zanati Bazan, Gabriel Pereira Braga, Rodrigo Bazan
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disease characterized by clonal hematopoietic stem cell disorder, with increased mortality and morbidity. Venous thrombosis is the most common cause of mortality in PNH. The relationship between PNH and cerebrovascular disease is unclear; few cases are reported in the literature, most of them related to cerebral venous thrombosis; In PNH the involvement of intracranial and extracranial arterial sites is very rare. We report a case of a 49-year-old woman who has a medical history of diabetes mellitus, hypertension, and PNH and presented multiple lacunar strokes in a routine consultation with a hematologist...
August 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28776182/progressive-deficit-in-isolated-pontine-infarction-the-association-with-etiological-subtype-lesion-topography-and-outcome
#17
Elif Gökçal, Elvin Niftaliyev, Gözde Baran, Çiğdem Deniz, Talip Asil
It is important to predict progressive deficit (PD) in isolated pontine infarction, a relatively common problem of clinical stroke practice. Traditionally, lacunar infarctions are known with their progressive course. However, few studies have analyzed the branch atheromatous disease subtype as a subtype of lacunar infarction, separately. There are also conflicting results regarding the relationship with the topography of lesion and PD. In this study, we classified etiological subtypes and lesion topography in isolated pontine infarction and aimed to investigate the association of etiological subtypes, lesion topography and clinical outcome with PD...
August 3, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28768822/intravenous-immunoglobulin-for-maintenance-treatment-of-chronic-inflammatory-demyelinating-polyneuropathy-a-multicentre-open-label-52-week-phase-iii-trial
#18
Satoshi Kuwabara, Masahiro Mori, Sonoko Misawa, Miki Suzuki, Kazutoshi Nishiyama, Tatsuro Mutoh, Shizuki Doi, Norito Kokubun, Mikiko Kamijo, Hiroo Yoshikawa, Koji Abe, Yoshihiko Nishida, Kazumasa Okada, Kenji Sekiguchi, Ko Sakamoto, Susumu Kusunoki, Gen Sobue, Ryuji Kaji
OBJECTIVE: Short-term efficacy of induction therapy with intravenous immunoglobulin (Ig) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) is well established. However, data of previous studies on maintenance therapy were limited up to 24-week treatment period. We aimed to investigate the efficacy and safety of longer-term intravenous Ig therapy for 52 weeks. METHODS: This study was an open-label phase 3 clinical trial conducted in 49 Japanese tertiary centres...
August 2, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28765289/vascular-risk-factor-profiles-differ-between-magnetic-resonance-imaging-defined-subtypes-of-younger-onset-lacunar-stroke
#19
Loes C A Rutten-Jacobs, Hugh S Markus
BACKGROUND AND PURPOSE: Differing associations of vascular risk factors with lacunar infarct have been reported, which is likely because of diagnostic differences and possible heterogeneity in the pathogenesis underlying lacunar infarction. In a large magnetic resonance imaging-verified cohort of lacunar infarct patients, we investigated the risk factor profile of lacunar infarction and magnetic resonance imaging characteristics. METHODS: One thousand twenty-three patients with lacunar infarction (mean age, 56...
September 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28760409/development-and-reliability-of-a-user-friendly-multicenter-phenotyping-application-for-hemorrhagic-and-ischemic-stroke
#20
Mayowa Owolabi, Godwin Ogbole, Rufus Akinyemi, Kehinde Salaam, Onoja Akpa, Pattanasak Mongkolwat, Adeleye Omisore, Atinuke Agunloye, Richard Efidi, Joseph Odo, Akintomiwa Makanjuola, Albert Akpalu, Fred Sarfo, Lukman Owolabi, Reginald Obiako, Kolawole Wahab, Emmanuel Sanya, Philip Adebayo, Morenikeji Komolafe, Abiodun Moshood Adeoye, Michael B Fawale, Joshua Akinyemi, Godwin Osaigbovo, Taofiki Sunmonu, Paul Olowoyo, Innocent Chukwuonye, Yahaya Obiabo, Philip Ibinaiye, Abdul Dambatta, Yaw Mensah, Salaam Abdul, Eunice Olabinri, Joyce Ikubor, Olalekan Oyinloye, Femi Odunlami, Ezinne Melikam, Raelle Saulson, Philip Kolo, Adesola Ogunniyi, Bruce Ovbiagele
BACKGROUND: Annotation and Image Markup on ClearCanvas Enriched Stroke-phenotyping Software (ACCESS) is a novel stand-alone computer software application that allows the creation of simple standardized annotations for reporting brain images of all stroke types. We developed the ACCESS application and determined its inter-rater and intra-rater reliability in the Stroke Investigative Research and Educational Network (SIREN) study to assess its suitability for multicenter studies. METHODS: One hundred randomly selected stroke imaging reports from 5 SIREN sites were re-evaluated by 4 trained independent raters to determine the inter-rater reliability of the ACCESS (version 12...
July 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
keyword
keyword
86472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"