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procalcitonin in chronic renal disease

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https://www.readbyqxmd.com/read/29148856/novel-applications-for-serum-procalcitonin-testing-in-clinical-practice
#1
Justin J Choi, Matthew W McCarthy
Procalcitonin has emerged as a reliable marker of acute bacterial infection in hospitalized patients and the assay has recently been incorporated into several clinical algorithms to reduce antimicrobial overuse, but its use in patients with end-organ dysfunction is controversial. Areas covered: In this review, the authors examine what is known about procalcitonin testing in patients with organ dysfunction, including those with end-stage renal disease, congestive heart failure, chronic obstructive pulmonary disease, and cirrhosis, and explore how the assay is now being used in the management of non-infectious diseases...
November 17, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29148026/the-influence-of-hemodialysis-membrane-permeability-on-serum-procalcitonin-values-in-patients-on-maintenance-hemodialysis
#2
Taoufiq Aatif, Yassir Zajjari, Anas Jeaidi
BACKGROUND: Procalcitonin (PCT) has emerged as a marker of infection and it could be useful for detection of systemic bacterial infections in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). The aim of this study was to assess the influence of HD membrane permeability to PCT serum levels in noninfected HD patients on maintenance HD. METHODS: In a prospective comparative study, we measured PCT serum levels and C reactive protein (CRP) before and after HD in 36 sessions (18 sessions of HD with low-flux = Group L; and 18 sessions with high flux membranes = Group H), in 18 chronic HD patients without history of infection...
November 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28956241/predictive-value-of-procalcitonin-for-diagnosis-of-infections-in-patients-with-chronic-kidney-disease-a-comparison-with-traditional-inflammatory-markers-c-reactive-protein-white-blood-cell-count-and-neutrophil-percentage
#3
Yanbei Sun, Lijuan Jiang, Xiaonan Shao
PURPOSE: To investigate the predictive value of procalcitonin (PCT) in patients with stage 1-4 and stage 5 chronic kidney disease (CKD). METHODS: Five hundred and forty-one CKD inpatients were retrospectively analyzed and divided into CKD stage 1-4 (CKD1-4) and CKD stage 5 (CKD5) groups. Each group was further divided into non-infection, local infection, and sepsis subgroups. The clinical characteristics and inflammatory indexes of each subgroup including PCT, C-reactive protein (CRP), white blood cell count (WBC), and neutrophil percentage (N%) were compared, and the receiver operating characteristic curves to predict local infection and sepsis were plotted...
December 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28625233/-elevation-of-red-cell-distribution-width-during-hospitalization-predicts-mortality-in-patients-with-sepsis
#4
Yan Gong, Xianming Long, Jun Jin, Xinjing Yang, Jianhong Fu, Fang Huang, Jian Huang, Qiang Guo, Jun Wang
OBJECTIVE: To investigate the association of red cell distribution width (RDW) with prognosis in patients with sepsis. METHODS: Patients with sepsis admitted to intensive care unit (ICU) of the First Hospital of Soochow University from January 2011 to December 2016 were enrolled. All clinical data were collected for participants, which mainly included basic data, main underlying disease, site of infection, acute physiology and chronic health evaluation II(APACHE II) score, blood routine test, biochemical test, blood gas analysis, coagulation index, procalcitonin (PCT), hospitalization days, and 28-day and 90-day mortality...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28592028/-analysis-of-12-cases-of-exogenous-lipoid-pneumonia-confirmed-by-pathology
#5
Y X Wang, F Fang, Y F Guo, Y M Li, T Y Sun, M Zhang, J Chen, B M Fang
Objective: To study the etiological, clinical, radiological, diagnostic, therapeutic, and prognostic manifestations of exogenous lipoid pneumonia (ELP), and therefore to improve the diagnosis and treatment of this disease. Methods: The clinical data of 12 cases of ELP confirmed by pathology were retrospectively analyzed. Results: The patients consisted of 9 males and 3 females, with an average age of 73.8 years (range, 44 to 100 years). The underlying diseases were variable, including diseases affecting the general condition (multiple organ failure, chronic heart and renal insufficiency, pemphigoid, etc) and conditions with increased risk of aspiration (sequelae of cerebrovascular disease, Alzheimer's disease, advanced stage of nasopharyngeal carcinoma, paralytic ileus, etc)...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28505627/endothelial-damage-signals-refractory-acute-kidney-injury-in-critically-ill-patients
#6
Theis S Itenov, Jens-Ulrik Jensen, Sisse R Ostrowski, Pär I Johansson, Katrin M Thormar, Jens D Lundgren, Morten H Bestle
Critically ill patients with acute kidney injury (AKI) are heterogeneous on pathophysiology and prognosis. The role of endothelial damage in the pathogenesis of refractory AKI has not been clarified. The aim was to determine if biomarkers of endothelial damage, independently of the inflammatory insult on the kidney, can predict recovery of acute kidney injury. METHODS: From the "Procalcitonin And Survival Study" multicenter intensive care unit cohort, followed for 28 days after admission, we included patients without chronic kidney disease, who survived >24 h after admission and with plasma samples at admission available for biomarker analysis...
June 2017: Shock
https://www.readbyqxmd.com/read/28413520/prognosis-of-patients-with-acinetobacter-baumannii-infection-in-the-intensive-care-unit-a-retrospective-analysis
#7
Dong Xiao, Lu Wang, Daquan Zhang, Dongming Xiang, Qi Liu, Xuezhong Xing
The present retrospective study aimed to investigate the prognostic factors for critically ill patients with an Acinetobacter baumannii (A. baumannii) infection. A total of 37 patients from the intensive care unit (ICU) were enrolled in the study. Data was collected from patients, including age, gender, ethnicity, A. baumannii infection status, concurrent infection status, prescribed antibiotics, Acute Physiology and Chronic Health Evaluation II (APACHE II) and sepsis-related organ failure assessment (SOFA) scores, procalcitonin level, site of infection, shock, sepsis and renal replacement therapy status...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28125806/procalcitonin-and-interleukin-6-levels-are-they-useful-biomarkers-in-cardiac-surgery-patients
#8
Anna Clementi, Alessandra Brocca, Grazia Maria Virzì, Massimo de Cal, Davide Giavarina, Mariarosa Carta, María-Jimena Muciño-Bermejo, Tommaso Hinna Danesi, Loris Salvador, Claudio Ronco
BACKGROUND/AIM: Cardiac surgery-associated acute kidney injury is an independent predictor of chronic renal disease and mortality. The scope of this study was to determine the utility of procalcitonin (PCT) and plasma interleukin-6 (IL-6) levels in predicting renal outcome and mortality in these patients. METHODS: PCT and plasma IL-6 levels of 122 cardiac surgery patients were measured at 48 h after the surgical procedure. Primary endpoints were adverse renal outcome and mortality...
2017: Blood Purification
https://www.readbyqxmd.com/read/27067215/-usefulness-of-scd14-st-in-the-diagnosis-of-sepsis-in-patient-with-renal-failure
#9
REVIEW
Dario Galeano, Luca Zanoli, Pasquale Fatuzzo, Antonio Granata
Since many years, researchers have focused their studies to find out early sepsis biomarkers for the purpose of gaining time in the application of early goal-directed therapy protocol. Procalcitonin (PCT) is a reliable biomarker for sepsis, although it has a low specificity and prognostic value. Other recently proposed sepsis biomarkers such as interleukins, C-reactive protein (CRP), myeloid cells expressing triggering receptor-1 (TREM-1) and soluble urokinase-type plasminogen activator receptor (suPAR) still have a controversial and uncertain clinical value...
March 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26639228/bacterial-coinfection-is-associated-with-severity-of-avian-influenza-a-h7n9-and-procalcitonin-is-a-useful-marker-for-early-diagnosis
#10
Meifang Yang, Hainv Gao, Jiajia Chen, Xiaowei Xu, Lingling Tang, Yida Yang, Weifeng Liang, Liang Yu, Jifang Sheng, Lanjuan Li
Patients contracting avian influenza A (H7N9) often develop severe disease. However, information on the contribution of bacterial coinfection to the severity of H7N9 is limited. We retrospectively studied 83 patients with confirmed H7N9 infection from April 2013 to February 2014. The severity of patients with bacterial coinfection and markers for early diagnosis of bacterial coinfection in H7N9 were analyzed. We found Staphylococcus aureus was the most prevalent pathogen. Higher Acute Physiology and Chronic Health Evaluation II score, shock, renal replacement treatment, mechanical ventilation, and extracorporeal membrane oxygenation treatment were more frequently observed in patients with bacterial coinfection...
February 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/25228701/use-of-procalcitonin-in-patients-with-various-degrees-of-chronic-kidney-disease-including-renal-replacement-therapy
#11
Eddie Grace, R Mackenzie Turner
Procalcitonin (PCT) has been shown to be a useful surrogate marker in identifying patients with various bacterial infections. PCT has been studied as a diagnostic marker in differentiating bacterial pneumonia from other respiratory conditions such as chronic obstructive pulmonary disease exacerbations or viral pneumonia. Differentiating bacterial from nonbacterial pneumonia using PCT has shown to reduce antibiotic usage, length of stay, and antibiotic-related adverse effects. PCT has also been studied in patients with sepsis in an effort to reduce unnecessary antibiotic usage and decrease the length of antibiotic therapy...
December 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/25204316/omega-3-fatty-acids-inhibit-the-up-regulation-of-endothelial-chemokines-in-maintenance-hemodialysis-patients
#12
RANDOMIZED CONTROLLED TRIAL
Adriana M Hung, Cindy Booker, Charles D Ellis, Edward D Siew, Amy J Graves, Ayumi Shintani, Naji N Abumrad, Jonathan Himmelfarb, Talat Alp Ikizler
BACKGROUND: Chronic systemic inflammation is common in patients with chronic kidney disease on dialysis (CKD5D) and has been considered a key mediator of the increased cardiovascular risk in this patient population. In this study, we tested the hypothesis that supplementation of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) will attenuate the systemic inflammatory process in CKD5D patients. METHODS: The design was a randomized, double-blinded, placebo controlled pilot trial (NCT00655525)...
February 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25117718/salt-restriction-in-chronic-kidney-disease-a-simple-need-or-a-must
#13
REVIEW
Francesca Mallamaci, Giovanni Tripepi
Dietary salt restriction is one of the most important non pharmacological intervention in the management of hypertension and cardiovascular complications. In Chronic Kidney Disease (CKD) patients, observational and recent interventional studies investigating the relationship between sodium intake and renal outcomes suggest that low salt diet is warranted in this high risk category of patients. Moreover reducing and maintaining a low salt intake in these patients plays a fundamental role for maximizing the beneficial effect of ACE inhibitors on CKD progression...
2014: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/24502029/platelet-indices-in-patients-with-de-novo-portal-vein-thrombosis-and-liver-cirrhosis
#14
Irina Gîrleanu, Anca Trifan, Camelia Cojocariu, Mihaela Dimache, Ana-Maria Sîngeap, Oana Stoica, C Sfarti, C Stanciu
UNLABELLED: Platelet indices are markers of platelet reactivity used for thrombotic risk assessment in patients with cardiovascular diseases, and recently in venous thrombosis. AIM: To assess the diagnostic value of platelet indices in patients with non-malignant de novo portal vein thrombosis and liver cirrhosis. MATERIAL AND METHODS: We conducted a prospective, case-control study on patients admitted to a tertiary center in the interval January, 2010 - December, 2012...
July 2013: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/24140065/description-and-predictive-factors-of-infection-in-patients-with-chronic-kidney-disease-admitted-to-the-critical-care-unit
#15
Damien Contou, Géraldine d'Ythurbide, Jonathan Messika, Christophe Ridel, Antoine Parrot, Michel Djibré, Alexandre Hertig, Eric Rondeau, Muriel Fartoukh
OBJECTIVES: To describe the spectrum of infection and multidrug-resistant bacterial colonization, and to identify early predictors of infection in patients with chronic kidney disease (CKD) admitted to the critical care unit (CCU). METHODS: A 7-month observational prospective single-centre study in a French university hospital. RESULTS: 791 patients were admitted to the CCU, 135 of whom (17%) had severe CKD. Among these, 41 (30%) were infected on admission...
February 2014: Journal of Infection
https://www.readbyqxmd.com/read/23990496/procalcitonin-diagnostic-value-in-systemic-infections-in-chronic-kidney-disease-or-renal-transplant-patients
#16
Raluca Dumea, Dimitrie Siriopol, Simona Hogas, Irina Mititiuc, Adrian Covic
PURPOSE: Although procalcitonin (PCT) has been described as a marker of infection and inflammation, it has not been extensively studied in patients with chronic kidney disease (CKD), end stage renal disease, or renal transplant. METHODS: PCT was routinely tested in 82 (56 dialyzed patients and 28 renal transplant recipients) consecutive cases with a strong clinical suspicion of infection, during a 6-month period, in a single referral unit. RESULTS: During the study period, 58/82 cases had confirmed infections as per definition...
February 2014: International Urology and Nephrology
https://www.readbyqxmd.com/read/23957657/interleukin-18-crp-and-procalcitonin-levels-in-vesicoureteral-reflux-and-reflux-nephropathy
#17
Sevgi Yavuz, Ali Anarat, Aysun Karabay Bayazıt
BACKGROUND: Some patients with vesicoureteral reflux (VUR) develop reflux nephropathy (RN) and a number of them progress to chronic kidney disease (CKD). However, it is unclear to predict which patient will develop RN and/or CKD. The aim of this study is to evaluate the role of Interleukin-18 (IL-18), C-reactive protein (CRP) and procalcitonin (PCT) as an indicator of RN in VUR. METHODS: Ninety-three children aged 3.5-16 years with primary VUR were enrolled. Patients were divided into two groups according to the presence of renal scarring (RS)...
2013: Renal Failure
https://www.readbyqxmd.com/read/22073825/inflammation-markers-chronic-kidney-disease-and-renal-replacement-therapy
#18
Bernardo A Lavín-Gómez, Rosa Palomar-Fontanet, Maria Gago-Fraile, José A Quintanar-Lartundo, Estefanía Gómez-Palomo, Domingo González-Lamuño, Maria T García-Unzueta, Manuel A Arias-Rodríguez, Juan A Gómez-Gerique
Chronic kidney disease (CKD) is associated with a proinflammatory state and an excess of cardiovascular risk. In this work, we describe changes in inflammatory markers-C-reactive protein (CRP), pentraxin 3 (PTX3), serum component of amyloid A (SAA), and procalcitonin (PCT)--in CKD patients compared with a control group of subjects with a normal estimated glomerular filtration rate (eGFR). Blood samples were obtained from 69 healthy individuals (GP) and 70 end-stage CKD patients--25 not yet on dialysis, 22 on peritoneal dialysis (PD), and 23 on hemodialysis (HD)...
2011: Advances in Peritoneal Dialysis
https://www.readbyqxmd.com/read/21817883/serum-procalcitonin-levels-in-patients-with-myeloperoxidase-antineutrophil-cytoplasmic-antibodies-associated-glomerulonephritis
#19
Atsushi Komatsuda, Ayumi Omokawa, Takashi Fujiwara, Ryuta Sato, Masaru Togashi, Shin Okuyama, Ken-ichi Sawada, Hideki Wakui
INTRODUCTION: High serum procalcitonin (PCT) levels (≥0.5 ng/mL) commonly occur with systemic bacterial and fungal infections. Although several studies suggested that measuring serum PCT levels may serve as a useful marker to distinguish between active antineutrophil cytoplasmic antibodies (ANCA)-associated diseases and invasive infections, there is no information on PCT in myeloperoxidase (MPO)-ANCA-associated glomerulonephritis. METHODS: The authors measured serum PCT concentrations before initiation of immunosuppressive therapy in 67 patients with biopsy-proven MPO-ANCA-associated glomerulonephritis...
February 2012: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/20534760/plasma-procalcitonin-is-associated-with-obesity-insulin-resistance-and-the-metabolic-syndrome
#20
Ali Abbasi, Eva Corpeleijn, Douwe Postmus, Ron T Gansevoort, Paul E de Jong, Rijk O B Gans, Joachim Struck, Hans L Hillege, Ronald P Stolk, Gerjan Navis, Stephan J L Bakker
CONTEXT: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation. OBJECTIVES: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population. METHODS: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultrasensitive immunoluminometric assay...
September 2010: Journal of Clinical Endocrinology and Metabolism
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