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procalcitonin in chronic renal disease

Dario Galeano, Luca Zanoli, Pasquale Fatuzzo, Antonio Granata
Since many years, researchers have focused their studies to find out early sepsis biomarkers for the purpose of gaining time in the application of early goal-directed therapy protocol. Procalcitonin (PCT) is a reliable biomarker for sepsis, although it has a low specificity and prognostic value. Other recently proposed sepsis biomarkers such as interleukins, C-reactive protein (CRP), myeloid cells expressing triggering receptor-1 (TREM-1) and soluble urokinase-type plasminogen activator receptor (suPAR) still have a controversial and uncertain clinical value...
March 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Meifang Yang, Hainv Gao, Jiajia Chen, Xiaowei Xu, Lingling Tang, Yida Yang, Weifeng Liang, Liang Yu, Jifang Sheng, Lanjuan Li
Patients contracting avian influenza A (H7N9) often develop severe disease. However, information on the contribution of bacterial coinfection to the severity of H7N9 is limited. We retrospectively studied 83 patients with confirmed H7N9 infection from April 2013 to February 2014. The severity of patients with bacterial coinfection and markers for early diagnosis of bacterial coinfection in H7N9 were analyzed. We found Staphylococcus aureus was the most prevalent pathogen. Higher Acute Physiology and Chronic Health Evaluation II score, shock, renal replacement treatment, mechanical ventilation, and extracorporeal membrane oxygenation treatment were more frequently observed in patients with bacterial coinfection...
February 2016: Diagnostic Microbiology and Infectious Disease
Eddie Grace, R Mackenzie Turner
Procalcitonin (PCT) has been shown to be a useful surrogate marker in identifying patients with various bacterial infections. PCT has been studied as a diagnostic marker in differentiating bacterial pneumonia from other respiratory conditions such as chronic obstructive pulmonary disease exacerbations or viral pneumonia. Differentiating bacterial from nonbacterial pneumonia using PCT has shown to reduce antibiotic usage, length of stay, and antibiotic-related adverse effects. PCT has also been studied in patients with sepsis in an effort to reduce unnecessary antibiotic usage and decrease the length of antibiotic therapy...
December 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Adriana M Hung, Cindy Booker, Charles D Ellis, Edward D Siew, Amy J Graves, Ayumi Shintani, Naji N Abumrad, Jonathan Himmelfarb, Talat Alp Ikizler
BACKGROUND: Chronic systemic inflammation is common in patients with chronic kidney disease on dialysis (CKD5D) and has been considered a key mediator of the increased cardiovascular risk in this patient population. In this study, we tested the hypothesis that supplementation of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) will attenuate the systemic inflammatory process in CKD5D patients. METHODS: The design was a randomized, double-blinded, placebo controlled pilot trial (NCT00655525)...
February 2015: Nephrology, Dialysis, Transplantation
Francesca Mallamaci, Giovanni Tripepi
Dietary salt restriction is one of the most important non pharmacological intervention in the management of hypertension and cardiovascular complications. In Chronic Kidney Disease (CKD) patients, observational and recent interventional studies investigating the relationship between sodium intake and renal outcomes suggest that low salt diet is warranted in this high risk category of patients. Moreover reducing and maintaining a low salt intake in these patients plays a fundamental role for maximizing the beneficial effect of ACE inhibitors on CKD progression...
2014: Kidney & Blood Pressure Research
Irina Gîrleanu, Anca Trifan, Camelia Cojocariu, Mihaela Dimache, Ana-Maria Sîngeap, Oana Stoica, C Sfarti, C Stanciu
UNLABELLED: Platelet indices are markers of platelet reactivity used for thrombotic risk assessment in patients with cardiovascular diseases, and recently in venous thrombosis. AIM: To assess the diagnostic value of platelet indices in patients with non-malignant de novo portal vein thrombosis and liver cirrhosis. MATERIAL AND METHODS: We conducted a prospective, case-control study on patients admitted to a tertiary center in the interval January, 2010 - December, 2012...
July 2013: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Damien Contou, Géraldine d'Ythurbide, Jonathan Messika, Christophe Ridel, Antoine Parrot, Michel Djibré, Alexandre Hertig, Eric Rondeau, Muriel Fartoukh
OBJECTIVES: To describe the spectrum of infection and multidrug-resistant bacterial colonization, and to identify early predictors of infection in patients with chronic kidney disease (CKD) admitted to the critical care unit (CCU). METHODS: A 7-month observational prospective single-centre study in a French university hospital. RESULTS: 791 patients were admitted to the CCU, 135 of whom (17%) had severe CKD. Among these, 41 (30%) were infected on admission...
February 2014: Journal of Infection
Raluca Dumea, Dimitrie Siriopol, Simona Hogas, Irina Mititiuc, Adrian Covic
PURPOSE: Although procalcitonin (PCT) has been described as a marker of infection and inflammation, it has not been extensively studied in patients with chronic kidney disease (CKD), end stage renal disease, or renal transplant. METHODS: PCT was routinely tested in 82 (56 dialyzed patients and 28 renal transplant recipients) consecutive cases with a strong clinical suspicion of infection, during a 6-month period, in a single referral unit. RESULTS: During the study period, 58/82 cases had confirmed infections as per definition...
February 2014: International Urology and Nephrology
Sevgi Yavuz, Ali Anarat, Aysun Karabay Bayazıt
BACKGROUND: Some patients with vesicoureteral reflux (VUR) develop reflux nephropathy (RN) and a number of them progress to chronic kidney disease (CKD). However, it is unclear to predict which patient will develop RN and/or CKD. The aim of this study is to evaluate the role of Interleukin-18 (IL-18), C-reactive protein (CRP) and procalcitonin (PCT) as an indicator of RN in VUR. METHODS: Ninety-three children aged 3.5-16 years with primary VUR were enrolled. Patients were divided into two groups according to the presence of renal scarring (RS)...
2013: Renal Failure
Bernardo A Lavín-Gómez, Rosa Palomar-Fontanet, Maria Gago-Fraile, José A Quintanar-Lartundo, Estefanía Gómez-Palomo, Domingo González-Lamuño, Maria T García-Unzueta, Manuel A Arias-Rodríguez, Juan A Gómez-Gerique
Chronic kidney disease (CKD) is associated with a proinflammatory state and an excess of cardiovascular risk. In this work, we describe changes in inflammatory markers-C-reactive protein (CRP), pentraxin 3 (PTX3), serum component of amyloid A (SAA), and procalcitonin (PCT)--in CKD patients compared with a control group of subjects with a normal estimated glomerular filtration rate (eGFR). Blood samples were obtained from 69 healthy individuals (GP) and 70 end-stage CKD patients--25 not yet on dialysis, 22 on peritoneal dialysis (PD), and 23 on hemodialysis (HD)...
2011: Advances in Peritoneal Dialysis
Atsushi Komatsuda, Ayumi Omokawa, Takashi Fujiwara, Ryuta Sato, Masaru Togashi, Shin Okuyama, Ken-ichi Sawada, Hideki Wakui
INTRODUCTION: High serum procalcitonin (PCT) levels (≥0.5 ng/mL) commonly occur with systemic bacterial and fungal infections. Although several studies suggested that measuring serum PCT levels may serve as a useful marker to distinguish between active antineutrophil cytoplasmic antibodies (ANCA)-associated diseases and invasive infections, there is no information on PCT in myeloperoxidase (MPO)-ANCA-associated glomerulonephritis. METHODS: The authors measured serum PCT concentrations before initiation of immunosuppressive therapy in 67 patients with biopsy-proven MPO-ANCA-associated glomerulonephritis...
February 2012: American Journal of the Medical Sciences
Ali Abbasi, Eva Corpeleijn, Douwe Postmus, Ron T Gansevoort, Paul E de Jong, Rijk O B Gans, Joachim Struck, Hans L Hillege, Ronald P Stolk, Gerjan Navis, Stephan J L Bakker
CONTEXT: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation. OBJECTIVES: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population. METHODS: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultrasensitive immunoluminometric assay...
September 2010: Journal of Clinical Endocrinology and Metabolism
Karin Malícková, Helena Brodská, Jana Lachmanová, Sylvie Dusilová Sulková, Ivana Janatková, Helena Marecková, Vladimír Tesar, Tomás Zima
OBJECTIVE: The current study aimed to evaluate plasma calprotectin levels and clearance end-stage renal disease (ESRD) patients with and without acute infection undergoing chronic hemodialysis (HD). MATERIALS AND METHODS: Blood samples from 54 HD patients were obtained before and after the HD and 42 healthy blood donors were examined as controls. The blood levels of calprotectin, procalcitonin, C-reactive protein (CRP), and intracellular production of interleukins 10 and 12 in monocytes were determined in both groups...
April 2010: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Y Caliskan, H Oflaz, H Pusuroglu, H Boz, H Yazici, S Tamer, K Karsidag, A Yildiz
BACKGROUND: Hepatitis C virus (HCV) infection is associated with increased levels of inflammatory markers and is also a significant risk factor for the development of Type 2 diabetes mellitus (DM) in the general population. In attempt to address this issue in chronic hemodialysis (HD) patients, we evaluated the relation of HCV infection with inflammatory markers, endothelial dysfunction, insulin resistance and atherosclerosis. METHODS: In a cohort of 72 HD patients (36 (50%) had a positive HCV EIA test and 36 (50%) had a negative anti-HCV test), we examined HCV antibody status, insulin resistance (HOMA-IR) and beta-cell function (HOMA-beta), serum inflammatory parameters (high sensitive C-reactive protein (CRP), fibrinogen and procalcitonin), and performed echocardiography, high-resolution brachial artery ultrasound and B-mode carotid Doppler examination to assess the vascular functions and atherosclerosis...
February 2009: Clinical Nephrology
Andrzej Kraśniak, Maciej Drozdz, Mieczysław Pasowicz, Grzegorz Chmiel, Martyna Kowalczyk-Michałek, Dorota Szumilak, Piotr Podolec, Piotr Klimeczek, Małgorzata Konieczyńska, Ewa Wicher-Muniak, Wiesława Tracz, Władysław Sułowicz, Tilman Drueke
Atherosclerosis and calcifications in the cardio-vascular system are the most frequent causes of increased morbidity and mortality in patients with end-stage renal disease treated with hemodialyses. The aim of this study was to estimate the atherosclerosis progression and presence of calcifications in the circulatory system in patients treated with hemodialyses using, non-invasive imaging diagnostic techniques and to search for the relationships between these changes and microinflammation and oxidative stress during two years...
2007: Przegla̧d Lekarski
Hélène Decaluwe, Lisa M Harrison, Michele M Mariscalco, Dominique Gendrel, Claude Bohuon, Vernon L Tesh, François Proulx
Shiga toxin producing Escherichia coli (STEC) are noninvasive enteric pathogens that may cause hemorrhagic colitis (HC) and diarrhea-associated hemolytic uremic syndrome (D+ HUS). We hypothesized that development of D+ HUS is associated with increased serum procalcitonin (PCT) levels. PCT was measured by an immunoluminometric assay in 113 patients. Concentrations of PCT were different in normal controls, disease control groups (rotavirus enteritis, HC due to non-STEC pathogens, chronic renal failure), and children with uncomplicated O157:H7 HC or D+ HUS...
April 2006: Pediatric Research
Fabien Stucker, François Herrmann, Jean-Daniel Graf, Jean-Pierre Michel, Karl Heinz Krause, Gaëtan Gavazzi
OBJECTIVES: To compare the usefulness of procalcitonin (PCT) in detecting infection in elderly patients with that of other clinical and biological markers. DESIGN: Prospective observational study to compare PCT levels in infected and uninfected patients. SETTING: Geriatric teaching hospital in Switzerland. PARTICIPANTS: Two hundred eighteen elderly patients aged 75 and older admitted to an acute geriatric care unit. MEASUREMENTS: Demographic characteristics, comorbidities, Charlson index, general signs (respiratory rate, temperature, pulse rate, confusion, falls, shivering), presence of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, functional score (Functional Independence Measurement (FIM)) biological parameters (PCT, C-reactive protein (CRP), leukocytes, albumin), and definite diagnosis at admission were collected prospectively for each patient...
August 2005: Journal of the American Geriatrics Society
G Visvardis, Ioannis Griveas, A Fleva, A Giannakou, D Papadopoulou, E Mitsopoulos, P Kyriklidou, E Manou, E Ginikopoulou, D Meimaridou, K Pavlitou, G Sakellariou
PURPOSE: The objective of this study was to evaluate the diagnostic value of serum procalcitonin (PCT) in hemodialysis (HD) patients and its correlation to other traditional inflammatory markers. METHODS: We measured plasma PCT levels in 120 patients on maintenance HD. PCT levels were compared with C-reactive protein (CRP), interleukin-6 (IL-6), prealbumin, and albumin. We also examined the above parameters subgroups, especially in diabetics and the elderly. Relations between parameters were studied by Spearman's correlation...
2005: Renal Failure
Gerald Steinbach, Edwin Bölke, Adolf Grünert, Martin Störck, Klaus Orth
BACKGROUND: Bacterial infections are associated with a high morbidity and mortality rate in patients with acute and chronic renal failure. Because C-reactive-protein (CRP) is elevated in many patients with renal failure, even in the absence of infection, procalcitonin (PCT) might be useful for the detection of systemic bacterial infections. This cross-sectional observation study measured PCT and CRP in several groups of patients with various types, degrees and treatments of kidney diseases, including patients with sepsis treated with renal replacement therapy...
December 30, 2004: Wiener Klinische Wochenschrift
S Herget-Rosenthal, T Klein, G Marggraf, T Hirsch, H-G Jakob, T Philipp, A Kribben
Serum procalcitonin (PCT), an accurate marker of severe infection, is moderately increased in chronic kidney disease (CKD), peritoneal dialysis (PD) and haemodialysis (HD). We studied the extent of PCT elevation and factors accounting for elevated PCT in CKD and dialysis, and whether peripheral blood mononuclear cells (PBMC) contribute to increased PCT. In 37 controls, 281 CKD, 31 PD, and 65 HD patients without infection, PCT was measured and correlated with CKD stage, PD, HD, C-reactive protein (CRP), cardiovascular disease (CVD) and other clinical parameters...
February 2005: Scandinavian Journal of Immunology
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