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EV71 vaccine

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https://www.readbyqxmd.com/read/29777102/a-virus-like-particle-based-tetravalent-vaccine-for-hand-foot-and-mouth-disease-elicits-broad-and-balanced-protective-immunity
#1
Wei Zhang, Wenlong Dai, Chao Zhang, Yu Zhou, Pei Xiong, Shuxia Wang, Xiaohua Ye, Qingwei Liu, Dongming Zhou, Zhong Huang
Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants and children, causing considerable morbidity and mortality worldwide. HFMD is commonly caused by enterovirus 71 (EV71) and coxsackieviruses A16 (CVA16), A6 (CVA6), and A10 (CVA10). Formalin-inactivated EV71 vaccines are currently available in China; however, these vaccines fail to confer cross-protection against infections by other HFMD-causing enteroviruses, highlighting the necessity of developing a multivalent HFMD vaccine...
May 18, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29776754/willingness-and-influential-factors-of-parents-to-vaccinate-their-children-with-novel-inactivated-enterovirus-71-vaccines-in-guangzhou-china
#2
Tiegang Li, Hui Wang, Yin Lu, Qin Li, Chun Chen, Dahu Wang, Meixia Li, Yilan Li, Jianyun Lu, Zongqiu Chen, Yu Ma, Wenhui Liu, Mengmeng Ma, Di Wu, Jiachun Lu, Zhicong Yang
Hand, foot and mouth disease (HFMD) primarily affects children younger than 5 years of age. Recently, HFMD has ranked as the top notifiable infectious disease in China. In December 2015, China approved two novel inactivated enterovirus 71 vaccines (EV71 vaccines) for HFMD. Parents' acceptance is often essential for vaccination program success. The goal of this study was to identify willingness and influential factors to vaccinate among parents of kindergarteners in Guangzhou, China. A cross-sectional survey of face-to-face interviews was conducted from March to July 2016...
May 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29730555/harmine-a-small-molecule-derived-from-natural-sources-inhibits-enterovirus-71-replication-by-targeting-nf-%C3%AE%C2%BAb-pathway
#3
Deyan Chen, Xiaoyan Tian, Xue Zou, Shijie Xu, Huanru Wang, Nan Zheng, Zhiwei Wu
Enterovirus 71 (EV71) infection of young children can cause neurological manifestations, which is mainly responsible for the fatality. Although a vaccine is recently available for preventing enterovirus 71 infection, its efficacy remains to be seen. Therefore, there is a pressing need for anti-viral agents for the treatment of EV71 infection. By screening a natural compound library for inhibitory activity of EV71 replication, we identified a small molecule, harmine, that inhibited EV71 replication by targeting NF-κB signaling pathway...
May 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29619599/inactivated-enterovirus-71-with-poly-%C3%AE-glutamic-acid-chitosan-nano-particles-pc-nps-induces-high-cellular-and-humoral-immune-responses-in-balb-c-mice
#4
Prabuddha S Pathinayake, W A Gayan Chathuranga, Hyun-Cheol Lee, Mohammed Y E Chowdhury, Moon-Hee Sung, Jong-Soo Lee, Chul-Joong Kim
Enterovirus 71 (EV71) is the major causative agent of hand-foot-and-mouth disease (HFMD) and many neurological manifestations. Recently, this virus has become a serious concern because of consecutive epidemics in the Asia-Pacific region. However, no effective vaccine for EV71 has been discovered except two EV71 vaccines which are being used in local communities of China. To develop a safe and efficient EV71 vaccine candidate, we generated inactivated EV71 and evaluated its efficacy with γ-PGA/Chitosan nanoparticles (PC NPs), which are safe, biodegradable and effective as an adjuvant...
April 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29582164/induction-of-a-high-titered-antibody-response-using-hiv-gag-ev71-vp1-based-virus-like-particles-with-the-capacity-to-protect-newborn-mice-challenged-with-a-lethal-dose-of-enterovirus-71
#5
Xi Wang, Ke Dong, Min Long, Fang Lin, Zhaowei Gao, Lin Wang, Zhe Zhang, Xi Chen, Ying Dai, Huiping Wang, Huizhong Zhang
Enterovirus 71 (EV71) is the most frequently detected causative agent in hand, foot, and mouth disease (HFMD) and is a serious threat to public health in the Asia-Pacific region. Many EV71 vaccines are under development worldwide, and although both inactivated virus vaccines and virus-like particles (VLPs) are considered to be effective, the main focus has been on inactivated EV71vaccines. There have been very few studies on EV71 VLPs. In this study, using a strategy based on HIV gag VLPs, we constructed a gag-VP1 fusion gene to generate a recombinant baculovirus expressing the EV71 structural protein VP1 together with gag, which was then used to infect TN5 cells to form VLPs...
March 27, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29572108/establishment-of-the-1st-who-international-standard-for-anti-ev71-serum-human
#6
Gillian Cooper, Qunying Mao, Laura Crawt, Yiping Wang, Thomas Dougall, Peter Rigsby, Zhenglun Liang, Miao Xu, Philip Minor, Junzhi Wang, Javier Martin
Enterovirus A71 (EV71) is the major causative agent of severe and fatal hand, foot and mouth disease. There is plenty of evidence that EV71 has circulated widely in the Western Pacific Region for the last twenty years. Vaccines against EV71 are already available or under development. A collaborative study to establish the 1st WHO International Standard for anti-EV71 serum (Human) was conducted to ensure that methods used to measure the serum neutralizing activity or antibody levels against EV71 are accurate, sensitive and reproducible...
March 20, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29482422/five-year-immunity-persistence-following-immunization-with-inactivated-enterovirus-71-type-ev71-vaccine-in-healthy-children-a-further-observation
#7
Yuemei Hu, Gang Zeng, Kai Chu, Jing Zhang, Weixiao Han, Ying Zhang, Jing Li, Fengcai Zhu
The longevity of antibodies induced by inactivated enterovirus 71 type (EV71) vaccine is not well studied. To estimate the immunity persistence following two-dose vaccination of EV71 vaccine, a five-year follow-up study was conducted as an extension of a Phase III clinical trial. In this study, a sub-cohort of volunteers who was eligible for enrollment and randomly administrated either 2 dose EV71 vaccine or placebo in the phase III clinical trial was selected, and then further observed 64 months post the 1st vaccination...
February 26, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29401726/epidemiological-characteristics-and-spatial-temporal-distribution-of-hand-foot-and-mouth-disease-in-chongqing-china-2009-2016
#8
Li Qi, Wenge Tang, Han Zhao, Hua Ling, Kun Su, Hua Zhao, Qin Li, Tao Shen
(1) Objective : Even with licensed vaccine for enterovirus 71 (EV71) put into market in 2016 in China, hand, foot, and mouth disease (HFMD) is still a threat for children's health in Chongqing. We described the epidemiological characteristics and spatial-temporal patterns of HFMD in Chongqing from 2009 to 2016, in order to provide information and evidence for guiding public health response and intervention. (2) Methods : We retrieved the HFMD surveillance data from January 2009 to December 2016 from "National Disease Reporting Information System", and then analyzed demographic and geographical information integrally...
February 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29398272/development-of-a-high-growth-enterovirus-71-vaccine-candidate-inducing-cross-reactive-neutralizing-antibody-responses
#9
Min-Yuan Chia, Wan-Yu Chung, Chun-Hsiung Wang, Wei-Hau Chang, Min-Shi Lee
Although Enterovirus 71 (EV71) has only one serotype based on serum neutralization tests using hyperimmune animal antisera, three major genogroups (A, B and C) including eleven genotypes (A, B1-B2, and C1-C5) can be well classified based on phylogenetic analysis. Since 1997, large-scale EV71 epidemics occurred cyclically with different genotypes in the Asia-Pacific region. Therefore, development of EV71 vaccines is a national priority in several Asian countries. Currently, five vaccine candidates have been evaluated in clinical trials in China (three C4 candidates), Singapore (one B2 candidate), and Taiwan (one B4 candidate)...
February 21, 2018: Vaccine
https://www.readbyqxmd.com/read/29370243/inhibition-of-ev71-by-curcumin-in-intestinal-epithelial-cells
#10
Hsing-I Huang, Chi-Chong Chio, Jhao-Yin Lin
EV71 is a positive-sense single-stranded RNA virus that belongs to the Picornaviridae family. EV71 infection may cause various symptoms ranging from hand-foot-and-mouth disease to neurological pathological conditions such as aseptic meningitis, ataxia, and acute transverse myelitis. There is currently no effective treatment or vaccine available. Various compounds have been examined for their ability to restrict EV71 replication. However, most experiments have been performed in rhabdomyosarcoma or Vero cells...
2018: PloS One
https://www.readbyqxmd.com/read/29363365/a-comparative-analysis-of-immunogenicity-and-safety-of-an-enterovirus-71-vaccine-between-children-aged-3-5-years-and-infants-aged-6-35-months
#11
Wei Gu, Gang Zeng, Yue-Mei Hu, Yuan-Sheng Hu, Ying Zhang, Ya-Ling Hu, Yang Wang, Jing-Xin Li, Feng-Cai Zhu
BACKGROUND: The Sinovac enterovirus 71 (EV71) vaccine has shown good safety, immunogenicity, and efficacy in infants aged 6-35 months, whom are considered as the priority of the target population. However, 3-5 years old children accounted for approximately 30% of HFMD cases and are also worth our attention. METHODS: A randomized, double-blind, placebo-controlled, batch-to-batch consistency clinical trial enrolling 1400 participants aged 6-59 months was performed...
March 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29362406/epidemiological-and-serological-surveillance-of-hand-foot-and-mouth-disease-in-shanghai-china-2012-2016
#12
Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo, Xi Zhang, Yongzhang Zhu
Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infants and children in Shanghai from 2012-2016. Since 2013, CV-A6 has displaced EV71 and CV-A16 to become the predominant serotype. Interestingly, novel epidemiological patterns in EV71 and CV-A16 infections were observed, with one large peak in both 2012 and 2014, followed by two smaller peaks in the respective following years (2013 and 2015)...
January 24, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29337652/poorly-neutralizing-polyclonal-antibody-in-vitro-against-coxsackievirus-a16-circulating-strains-can-prevent-a-lethal-challenge-in-vivo
#13
Xin Yao, QunYing Mao, Yajing Li, Chunsheng Hao, LianLian Bian, Pan Chen, Fan Gao, Xing Wu, WeiWei Lu, Qiang Gao, XiuLing Li, Zhenglun Liang
Neutralizing antibodies (NTAbs) is a major criterion for evaluation the immunogenicity of many vaccines, for example, poliovirus and EV71 vaccine. Here, we firstly discovered that polyclonal antibodies induced by inactivated CVA16 vaccine and lived CVA16 virus have poor ability to neutralize circulating CVA16 strains in vitro. However, the passive transfer of poorly neutralizing polyclonal antibodies can protect suckling mice from lethally challenged with circulating strains in vivo. In addition, the obvious dose response was found between the titer of antibodies and the survival rate...
January 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29216216/epidemiological-and-genetic-characteristics-of-ev71-in-hand-foot-and-mouth-disease-in-guangxi-southern-china-from-2010-to-2015
#14
Minmei Chen, Yu Ju, Min Chen, Zhenguo Xie, Kaijiao Zhou, Yi Tan, Jianjun Mo
Hand, foot, and mouth disease (HFMD) is a significant public health challenge in China. Human enterovirus 71 (EV71) is regarded as the predominant causative pathogen of HFMD. Since 2015, two inactivated EV71 vaccines have been approved in mainland China, and because their use could change the HFMD pathogen spectrum, this should now be monitored. However, the epidemiological and genetic trends of EV71 with respect to HFMD in Guangxi, southern China, are still not clear. In this study, we describe the epidemiological and genetic characterization of this virus in clinically-diagnosed HFMD reported from 2010 to 2015 in Guangxi...
2017: PloS One
https://www.readbyqxmd.com/read/29129453/hepatitis-b-virus-core-particles-containing-multiple-epitopes-confer-protection-against-enterovirus-71-and-coxsackievirus-a16-infection-in-mice
#15
Chunling Huo, Jie Yang, Lei Lei, Lei Qiao, Jiantao Xin, Zishu Pan
Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand-foot-and-mouth disease (HFMD). To investigate novel combined vaccines to prevent EV71 and CA16 infection, we constructed chimeric virus-like particles (tHBc/SPA or tHBc/SP VLPs) displaying conserved epitopes of EV71 (aa 208-222 of VP1 and aa 248-263 of VP2) and CA16 (aa271-285 of VP1) using a truncated hepatitis B virus core carrier (tHBc). Immunization with the chimeric VLPs induced epitope- or virus-specific IgG and neutralization antibodies against EV71 and CA16 in the mice...
December 19, 2017: Vaccine
https://www.readbyqxmd.com/read/29093091/a-3-0-angstrom-resolution-cryo-electron-microscopy-structure-and-antigenic-sites-of-coxsackievirus-a6-like-particles
#16
Jinhuan Chen, Chao Zhang, Yu Zhou, Xiang Zhang, Chaoyun Shen, Xiaohua Ye, Wen Jiang, Zhong Huang, Yao Cong
Coxsackievirus A6 (CVA6) has recently emerged as one of the predominant causative agents of hand, foot, and mouth disease (HFMD). The structure of the CVA6 mature viral particle has not been solved thus far. Our previous work shows that recombinant virus-like particles (VLPs) of CVA6 represent a promising CVA6 vaccine candidate. Here, we report the first cryo-electron microscopy (cryo-EM) structure of the CVA6 VLP at 3.0-Å resolution. The CVA6 VLP exhibits the characteristic features of enteroviruses but presents an open channel at the 2-fold axis and an empty, collapsed VP1 pocket, which is broadly similar to the structures of the enterovirus 71 (EV71) VLP and coxsackievirus A16 (CVA16) 135S expanded particle, indicating that the CVA6 VLP is in an expanded conformation...
January 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29073897/a-comparative-study-of-multiple-clinical-enterovirus-71-isolates-and-evaluation-of-cross-protection-of-inactivated-vaccine-strain-fy-23%C3%A2-k-b-in-vitro
#17
Ting Yang, Hua Li, Lei Yue, Xia Song, Tianhong Xie, Shaohui Ma, Huaqing Meng, Ye Zhang, Xin He, Runxiang Long, Rong Yang, Fangyu Luo, Zhongping Xie, Qihan Li
BACKGROUND: Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease, which mostly affects infants and children and leads to severe neurological diseases. Vaccination offers the best option for disease control. We have screened the virus strain FY-23 K-B, which is used as an inactivated vaccine strain. An important issue in the development of vaccines is whether they provide cross protection against all other strains. METHODS: We collected and identified 19 clinical EV71 isolates from mainland China, which all belong to the C4 genotype...
October 26, 2017: Virology Journal
https://www.readbyqxmd.com/read/29070691/structure-immunogenicity-and-protective-mechanism-of-an-engineered-enterovirus-71-like-particle-vaccine-mimicking-80s-empty-capsid
#18
Xiaoli Wang, Zhiqiang Ku, Xiang Zhang, Xiaohua Ye, Jinhuan Chen, Qingwei Liu, Wei Zhang, Chao Zhang, Zhenglin Fu, Xia Jin, Yao Cong, Zhong Huang
Enterovirus 71 (EV71) is the major causative agent of severe hand, foot, and mouth disease, which affects millions of young children in the Asia-Pacific region annually. In this study, we engineered a novel EV71 virus-like particle (VLP) that lacks VP4 (therefore designated VLPΔVP4 ) and investigated its structure, antigenicity, and vaccine potential. The cryo-electron microscopy (cryo-EM) structure of VLPΔVP4 was reconstructed to 3.71-Å resolution. Results from structural and biochemical analyses revealed that VLPΔVP4 resembles the end product of the viral uncoating process, the 80S empty capsid...
January 1, 2018: Journal of Virology
https://www.readbyqxmd.com/read/28978937/microrna-134-regulates-poliovirus-replication-by-ires-targeting
#19
Abhijeet A Bakre, Byoung-Shik Shim, Ralph A Tripp
Global poliovirus eradication efforts include high vaccination coverage with live oral polio vaccine (OPV), surveillance for acute flaccid paralysis, and OPV "mop-up" campaigns. An important objective involves host-directed strategies to reduce PV replication to diminish viral shedding in OPV recipients. In this study, we show that microRNA-134-5p (miR-134) can regulate Sabin-1 replication but not Sabin-2 or Sabin-3 via direct interaction with the PV 5'UTR. Hypochromicity data showed miR-134 binding to Sabin-1 and 3 but not Sabin-2 IRES...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28970485/the-huc-mscs-cell-line-ccrc-1-represents-a-novel-safe-and-high-yielding-hdcs-for-the-production-of-human-viral-vaccines
#20
Ping Chen, Ke-Hua Zhang, Tao Na, Lin Wang, Wei-Dong Yin, Bao-Zhu Yuan, Jun-Zhi Wang
MRC-5 represents the most frequent human diploid cells (HDCs)-type cell substrate in the production of human viral vaccines. However, early-passage MRC-5 is diminishing and, due to both technical and ethical issues, it is extremely difficult to derive novel HDCs from fetal lung tissues, which are the common sources of HDCs. Our previous studies suggested that human umbilical cord may represent an alternative but convenient source of new HDCs. Here, we established a three-tiered cell banking system of a hUC-MSC line, designated previously as Cell Collection and Research Center-1 (CCRC-1)...
October 2, 2017: Scientific Reports
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