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EV71 vaccine

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https://www.readbyqxmd.com/read/28262332/report-from-the-world-health-organization-s-third-product-development-for-vaccines-advisory-committee-pdvac-meeting-geneva-8-10th-june-2016
#1
Birgitte K Giersing, Johan Vekemans, Samantha Nava, David C Kaslow, Vasee Moorthy
The third meeting of WHO's Product Development for Vaccines Advisory Committee (PDVAC) was held in June 2016, with a remit to revisit the pathogen areas for which significant progress has occurred since recommendations from the 2015 meeting, as well as to consider new advances in the development of vaccines against other pathogens. Since the previous meeting, significant progress has been made with regulatory approvals of the first malaria and dengue vaccines, and the first phase III trials of a respiratory syncytial virus (RSV) vaccine candidate has started in the elderly and pregnant women...
March 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28248924/microrna-screening-identifies-mir-134-as-a-regulator-of-poliovirus-and-enterovirus-71-infection
#2
Nichole Lynn Orr-Burks, Byoung-Shik Shim, Weilin Wu, Abhijeet A Bakre, Jon Karpilow, Ralph A Tripp
MicroRNAs (miRNAs) regulate virus replication through multiple mechanisms. Poliovirus causes a highly debilitating disease and though global efforts to eradicate polio have sharply decreased polio incidence, unfortunately three countries (Afghanistan, Nigeria and Pakistan) remain polio-endemic. We hypothesize that understanding the host factors involved in polio replication will identify novel prophylactic and therapeutic targets against polio and related viruses. In this data set, employing genome wide screens of miRNA mimics and inhibitors, we identified miRNAs which significantly suppressed polio replication...
March 1, 2017: Scientific Data
https://www.readbyqxmd.com/read/28168168/enterovirus-71-infection-and-vaccines
#3
REVIEW
Eun-Je Yi, Yun-Ju Shin, Jeong-Hwan Kim, Tae-Gyun Kim, Sun-Young Chang
Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28077584/2-year-efficacy-immunogenicity-and-safety-of-vigoo-enterovirus-71-vaccine-in-healthy-chinese-children-a-randomized-open-label-study
#4
Mingwei Wei, Fanyue Meng, Shiyuan Wang, Jingxin Li, Yuntao Zhang, Qunying Mao, Yuemei Hu, Pei Liu, Nianmin Shi, Hong Tao, Kai Chu, Yuxiao Wang, Zhenglun Liang, Xiuling Li, Fengcai Zhu
BACKGROUND:  This study evaluated the 2-year efficacy, immunogenicity, and safety of the Vigoo enterovirus 71 (EV71) vaccine. METHOD:  In an initial phase 3 study, we randomly assigned healthy infants and children aged 6-35 months (ratio, 1:1) to receive 2 doses of either EV71 vaccine (5120 participants) or placebo (5125 participants) at days 0 and 28, and followed them for 12 months after vaccination. In this extended follow-up study, we continued to evaluate the efficacy, immunogenicity, and safety of the EV71 vaccine for up to 2 years...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28042848/epidemiologic-features-of-enterovirus-71-associated-hand-foot-and-mouth-disease-from-2009-to-2013-in-zhejiang-china
#5
Zhifang Wang, Huakun Lv, Wenming Zhu, Zhe Mo, Guangming Mao, Xiaofeng Wang, Xiaoming Lou, Yongdi Chen
Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential target subject population(s) to be immunized with EV71 vaccine are not well understood. In this study, we characterized the epidemiology regarding EV71-associated HFMD on the basis of provincial-level surveillance...
December 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27974562/in-vivo-imaging-with-bioluminescent-enterovirus-71-allows-for-real-time-visualization-of-tissue-tropism-and-viral-spread
#6
Elizabeth A Caine, Jorge E Osorio
Hand, foot, and mouth disease (HFMD) is a reemerging illness caused by a variety of enteroviruses. The main causative agents are enterovirus 71 (EV71), coxsackievirus A16 (CVA16), and, most recently, coxsackievirus A6 (CVA6). Enterovirus infections can vary from asymptomatic infections to those with a mild fever and blisters on infected individuals' hands, feet, and throats to infections with severe neurological complications. Viral persistence for weeks postinfection (wpi) has also been documented by the demonstration of virus in children's stools...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27929745/an-elaborate-landscape-of-the-human-antibody-repertoire-against-enterovirus-71-infection-is-revealed-by-phage-display-screening-and-deep-sequencing
#7
Zhe Chen, Xianwen Ren, Jian Yang, Jie Dong, Ying Xue, Lilian Sun, Yafang Zhu, Qi Jin
Enterovirus 71 (EV71) causes outbreaks of hand, foot and mouth disease (HFMD), primarily in the Asia-Pacific area, that are often associated with complications of severe to fatal neurological symptoms. There are currently no anti-viral therapies or vaccines available for the treatment of EV71 infection. Illustrating human antibody responses neutralizing EV71 infection could potentially provide valuable information for the development of effective therapies and vaccines. Here, we constructed a comprehensive phage display library based on peripheral blood of eight EV71-infected donors and identified 27 EV71-specific human antibodies, of which four have neutralizing activity in in vitro experiments...
February 2017: MAbs
https://www.readbyqxmd.com/read/27902385/motor-coordination-and-balance-measurements-reveal-differential-pathogenicity-of-currently-spreading-enterovirus-71-strains-in-human-scarb2-transgenic-mice
#8
Mei-Feng Chen, Shin-Ru Shih
Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in the Asia-Pacific region. The C4a and B5 strains are the two major genotypes circulating in many countries recently. This study used a new protocol, a motor coordination task, to assess the differential pathogenicity of C4a and B5 strains in human SCARB2 transgenic mice. We found that the pathogenicity of C4a viruses was more severe than that of B5 viruses. Moreover, we discovered that an increased level of monocyte chemoattractant protein-1 was positively correlated with severely deficient motor function...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27826325/enterovirus-71-infection-and-neurological-complications
#9
REVIEW
Kyung Yeon Lee
Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and usually resolves spontaneously. However, EV71 occasionally involves the central nervous system (CNS), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27771182/a-novel-inactivated-enterovirus-71-vaccine-can-elicit-cross-protective-immunity-against-coxsackievirus-a16-in-mice
#10
Lisheng Yang, Yajing Liu, Shuxuan Li, Huan Zhao, Qiaona Lin, Hai Yu, Xiumin Huang, Qingbing Zheng, Tong Cheng, Ningshao Xia
Hand, foot, and mouth disease (HFMD) is a highly contagious disease that mainly affects infants and children. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the major pathogens of HFMD. Two EV71 vaccines were recently licensed in China and the administration of the EV71 vaccines is believed to significantly reduce the number of HFMD-related severe or fatal cases. However, a monovalent EV71 vaccine cannot cross-protect against CA16 infection, this may result in that it cannot effectively control the overall HFMD epidemic...
October 19, 2016: Vaccine
https://www.readbyqxmd.com/read/27748395/human-genome-wide-rnai-screen-reveals-host-factors-required-for-enterovirus-71-replication
#11
Kan Xing Wu, Patchara Phuektes, Pankaj Kumar, Germaine Yen Lin Goh, Dimitri Moreau, Vincent Tak Kwong Chow, Frederic Bard, Justin Jang Hann Chu
Enterovirus 71 (EV71) is a neurotropic enterovirus without antivirals or vaccine, and its host-pathogen interactions remain poorly understood. Here we use a human genome-wide RNAi screen to identify 256 host factors involved in EV71 replication in human rhabdomyosarcoma cells. Enrichment analyses reveal overrepresentation in processes like mitotic cell cycle and transcriptional regulation. We have carried out orthogonal experiments to characterize the roles of selected factors involved in cell cycle regulation and endoplasmatic reticulum-associated degradation...
October 17, 2016: Nature Communications
https://www.readbyqxmd.com/read/27645381/antiviral-activities-of-peptide-based-covalent-inhibitors-of-the-enterovirus-71-3c-protease
#12
Yong Wah Tan, Melgious Jin Yan Ang, Qiu Ying Lau, Anders Poulsen, Fui Mee Ng, Siew Wen Then, Jianhe Peng, Jeffrey Hill, Wan Jin Hong, Cheng San Brian Chia, Justin Jang Hann Chu
Hand, Foot and Mouth Disease is a highly contagious disease caused by a range of human enteroviruses. Outbreaks occur regularly, especially in the Asia-Pacific region, putting a burden on public healthcare systems. Currently, there is no antiviral for treating this infectious disease and the only vaccines are limited to circulation in China, presenting an unmet medical need that needs to be filled urgently. The human enterovirus 3 C protease has been deemed a plausible drug target due to its essential roles in viral replication...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27623347/single-dose-of-an-adenovirus-vectored-mouse-interferon-%C3%AE-protects-mice-from-lethal-ev71-challenge
#13
Jialei Sun, Jane Ennis, Jeffrey D Turner, Justin Jang Hann Chu
Enterovirus 71 (EV71) causes hand-foot-and-mouth diseases as well as neurological complications in young children. Interferon (IFN) can inhibit the replication of many viruses with low cytotoxic effects. Previously, an adenovirus vectored mouse interferon-α (DEF201), subtype 5, was generated by Wu et al, 2007. In this study, the antiviral effects of DEF201 against EV71 were evaluated in a murine model. 6-day-old BALB/c mice were administered a single dose of DEF201 before or after infection with lethal dose of EV71...
October 2016: Antiviral Research
https://www.readbyqxmd.com/read/27618078/the-current-status-of-the-disease-caused-by-enterovirus-71-infections-epidemiology-pathogenesis-molecular-epidemiology-and-vaccine-development
#14
REVIEW
Ping-Chin Chang, Shou-Chien Chen, Kow-Tong Chen
Enterovirus 71 (EV71) infections have a major public health impact in the Asia-Pacific region. We reviewed the epidemiology, pathogenesis, and molecular epidemiology of EV71 infection as well as EV71 vaccine development. Previous studies were found using the search terms "enterovirus 71" and "epidemiology" or "pathogenesis" or "molecular epidemiology" or "vaccine" in Medline and PubMed. Articles that were not published in the English language, manuscripts without an abstract, and opinion articles were excluded from the review...
September 9, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27533931/human-igg-fc-promotes-expression-secretion-and-immunogenicity-of-enterovirus-71-vp1-protein
#15
Juan Xu, Chunhua Zhang
Enterovirus (EV71) can cause severe neurological diseases, but the underlying pathogenesis remains unclear. The capsid protein, viral protein 1 (VP1), plays a critical role in the pathogenicity of EV71. High level expression and secretion of VP1 protein are necessary for structure, function and immunogenicity in its natural conformation. In our previous studies, 5 codon-optimized VP1 DNA vaccines, including wt-VP1, tPA-VP1, VP1-d, VP1-hFc and VP1-mFc, were constructed and analyzed. They expressed VP1 protein, but the levels of secretion and immunogenicity of these VP1 constructs were significantly different (P<0...
May 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27440896/a-single-mutation-in-the-vp1-of-enterovirus-71-is-responsible-for-increased-virulence-and-neurotropism-in-adult-interferon-deficient-mice
#16
Elizabeth A Caine, Louise H Moncla, Monica D Ronderos, Thomas C Friedrich, Jorge E Osorio
UNLABELLED: Hand, foot, and mouth disease (HFMD) has spread throughout the Asia-Pacific region, affecting millions of young children, who develop symptoms ranging from painful blisters around their mouths and hands to neurological complications. Many members of the genus Enterovirus (family Picornaviridae) cause HFMD. Enterovirus 71 (EV71) is one of the primary causative agents and has been linked to severe disease. Vaccine efficacy and pathogenesis studies for EV71 have been limited because there is a lack of suitable animal models...
October 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27373596/vesicular-stomatitis-virus-based-vaccines-expressing-ev71-virus-like-particles-elicit-strong-immune-responses-and-protect-newborn-mice-from-lethal-challenges
#17
Qin Yan, Linjuan Wu, Longyun Chen, Yali Qin, Zishu Pan, Mingzhou Chen
Enterovirus 71 (EV71) belonging to the Picornaviridae family is considered the most frequently detected causative agent in hand-foot-and-mouth disease (HFMD) and is a serious threat to public health in the Asia-Pacific region. There are currently no approved vaccines or effective drugs for EV71. In this study, using recombinant vesicular stomatitis virus (rVSV) expressing viral VP1 protein (mVP1) of EV71 as a control, we generated two types of rVSVs that can form EV71 virus-like particles (VLPs). First, we co-infected two rVSVs singly expressing P1 (mP1) and 3CD (m3CD) of EV71...
July 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27341804/antiviral-activity-of-lactobacillus-reuteri-protectis-against-coxsackievirus-a-and-enterovirus-71-infection-in-human-skeletal-muscle-and-colon-cell-lines
#18
Lei Yin Emily Ang, Horng Khit Issac Too, Eng Lee Tan, Tak-Kwong Vincent Chow, Pei-Chi Lynette Shek, Elizabeth Tham, Sylvie Alonso
BACKGROUND: Recurrence of hand, foot and mouth disease (HFMD) pandemics continues to threaten public health. Despite increasing awareness and efforts, effective vaccine and drug treatment have yet to be available. Probiotics have gained recognition in the field of healthcare worldwide, and have been extensively prescribed to babies and young children to relieve gastrointestinal (GI) disturbances and diseases, associated or not with microbial infections. Since the faecal-oral axis represents the major route of HFMD transmission, transient persistence of probiotic bacteria in the GI tract may confer some protection against HFMD and limit transmission among children...
June 24, 2016: Virology Journal
https://www.readbyqxmd.com/read/27273688/the-epidemiology-of-hand-foot-and-mouth-disease-in-asia-a-systematic-review-and-analysis
#19
Wee Ming Koh, Tiffany Bogich, Karen Siegel, Jing Jin, Elizabeth Y Chong, Chong Yew Tan, Mark Ic Chen, Peter Horby, Alex R Cook
CONTEXT: Hand, foot and mouth disease (HFMD) is a widespread pediatric disease caused primarily by human enterovirus 71 (EV-A71) and Coxsackievirus A16 (CV-A16). OBJECTIVE: This study reports a systematic review of the epidemiology of HFMD in Asia. DATA SOURCES: PubMed, Web of Science and Google Scholar were searched up to December 2014. STUDY SELECTION: Two reviewers independently assessed studies for epidemiologic and serologic information about prevalence and incidence of HFMD against predetermined inclusion/exclusion criteria...
October 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27206811/enterovirus-71-a-whole-virion-inactivated-enterovirus-71-vaccine
#20
Yang Zhou, Jing-Xin Li, Peng-Fei Jin, Yu-Xiao Wang, Feng-Cai Zhu
INTRODUCTION: Enterovirus A71 (EV71) is the predominant causative agent of hand, foot, and mouth disease (HFMD), which is often associated with severe cases and even deaths. EV71-associated epidemics have emerged as a serious threat to public health, particularly in the Asia-Pacific region. AREAS COVERED: We searched PubMed using the terms 'enterovirus 71', 'hand, foot, and mouth disease', and 'vaccine', with no date or language restrictions for all publications before April 27, 2016...
July 2016: Expert Review of Vaccines
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