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https://www.readbyqxmd.com/read/28324929/hyperthermia-by-electromagnetic-fields-to-enhanced-clinical-results-in-oncology
#1
Gerard C van Rhoon, Maarten M Paulides, Jeannette M L van Holthe, Martine Franckena
Confining treatment to the tumor to improve therapeutic outcome and reduce toxicity, is a hot issue in cancer research. Hyperthermia is recognized as a strong sensitizer for radiotherapy and chemotherapy enhancing tumor control without increasing toxicity. Today's electromagnetic hyperthermia systems heat large tissue volumes with limited ability to selectively heat the tumor. Fortunately, tremendous improvements in 3-dimensional electromagnetic & temperature modelling provide an exciting opportunity to design advanced multi-element electromagnetic applicator systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324818/exogenous-malic-acid-alleviates-cadmium-toxicity-in-miscanthus-sacchariflorus-through-enhancing-photosynthetic-capacity-and-restraining-ros-accumulation
#2
Haipeng Guo, Houming Chen, Chuntao Hong, Dean Jiang, Bingsong Zheng
Malic acid (MA) plays an important role in the regulation of plant growth, stomatal aperture, nutrition elements homeostasis and toxic metals tolerance. However, little is known about the effects of exogenous MA on physiological and biochemical responses to toxic metals in plants. To measure the alleviation roles of exogenous MA against cadmium (Cd), we determined the effects of MA on plant growth, net photosynthetic rate (Pn), reactive oxygen species (ROS) accumulation and the activities of anti-oxidant enzymes in the leaves of Miscanthus sacchariflorus (M...
March 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28324255/can-red-deer-antlers-be-used-as-an-indicator-of-environmental-and-edible-tissues-trace-element-contamination
#3
Aleksandra Giżejewska, Józef Szkoda, Agnieszka Nawrocka, Jan Żmudzki, Zygmunt Giżejewski
Venison is an attractive product for consumers concerned with healthy lifestyle; however, it can contain high levels of toxic elements, and therefore, it is a possible source of hazardous contaminants in human diet. Antlers are suitable bioindicators of environmental metal contamination, and herein, we assessed the ability of trace element levels in antlers to indicate levels in edible soft tissues. We determined the concentrations of lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), copper (Cu), zinc (Zn), and iron (Fe) in the liver, kidney, muscle, and antlers of 14 free-ranging red deer (Cervus elaphus) from northeastern Poland using atomic absorption spectrometry...
March 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28319901/a-novel-microbial-fuel-cell-sensor-with-biocathode-sensing-element
#4
Yong Jiang, Peng Liang, Panpan Liu, Donglin Wang, Bo Miao, Xia Huang
The traditional microbial fuel cell (MFC) sensor with bioanode as sensing element delivers limited sensitivity to toxicity monitoring, restricted application to only anaerobic and organic rich water body, and increased potential fault warning to the combined shock of organic matter/toxicity. In this study, the biocathode for oxygen reduction reaction was employed for the first time as the sensing element in MFC sensor for toxicity monitoring. The results shown that the sensitivity of MFC sensor with biocathode sensing element (7...
March 2, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319742/biochar-provides-a-safe-and-value-added-solution-for-hyperaccumulating-plant-disposal-a-case-study-of-phytolacca-acinosa-roxb-phytolaccaceae
#5
Shengsen Wang, Bin Gao, Yuncong Li, Yong Sik Ok, Chaofeng Shen, Shengguo Xue
In this work, an innovative approach using biochar technology for hyperaccumulator disposal was developed and evaluated. The heavy metal enriched P. acinosa biomass (PBM) was pyrolyzed to produce biochar (PBC). Both PBM and PBC were characterized with X-ray diffraction (XRD) for crystal phases, scanning electron microscopy (SEM) for surface topography, and analyzed for elemental composition and mobility. The results revealed that whewellite, a dominant crystal form in biomass, was decomposed to calcite after pyrolysis...
February 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28316048/toxic-elements-and-bio-metals-in-cantharellus-mushrooms-from-poland-and-china
#6
Jerzy Falandysz, Maria Chudzińska, Danuta Barałkiewicz, Małgorzata Drewnowska, Anetta Hanć
Data on multi-trace element composition and content relationships have been obtained for Cantharellus cibarius, C. tubaeformis, and C. minor mushrooms from Poland and China by inductive coupled plasma-dynamic reaction cell-mass spectroscopy. There is no previous data published on As, Li, V, Tl, and U in chanterelles from Poland and on Ba, Co, Cr, Ni, Rb, and Sr in chanterelles from China. The results implied a role of the soil background geochemistry at the collection site with the occurrence of Ag, As, Ba, Cr, Cs, Li, Mn, Pb, Rb, Sr, U, and V in the fruiting bodies...
March 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28315231/toxic-elements-in-the-stream-sediments-of-an-urbanized-basin-eastern-china-urbanization-greatly-elevates-their-adverse-biological-effects
#7
Pengbao Wu, Aijing Yin, Xiaohui Yang, Huan Zhang, Manman Fan, Chao Gao
The concentration of toxic elements (Hg, Cd, Cr, Cu, Pb, Zn, Ni and As) was measured in the sediments of the Qinhuai River in Eastern China along a rural to urban gradient. Multiple approaches were undertaken to evaluate the degree of enrichment and adverse biological effects of these elements. The results showed that the concentration of Hg, Cd, Zn, Cu and Pb increased exponentially from the agricultural headwater to the urbanized downstream, which reflects a severe anthropogenic influence. In addition, area-specific references, such as the local soil background (LSB) and upper continental crust (UCC) derived from the Yangtze craton, were more applicable for evaluating the enrichment of toxic elements in the Qinhuai River than was global UCC...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28314233/suburban-air-quality-human-health-hazard-assessment-of-potentially-toxic-elements-in-pm10
#8
Laura Megido, Beatriz Suárez-Peña, Luis Negral, Leonor Castrillón, Yolanda Fernández-Nava
PM10 samples were collected at two suburban locations in northern Spain, a traffic-industrial suburban (TIS) station located in the coastal city of Gijón and an industrial suburban (IS) station in Langreo, about 25 km inland. The aerosol samples were chemically analysed to determine ambient air concentrations of As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, V and Zn. The results showed that the mean levels of As, Co, Cu, Fe, Mn, Ni, Pb and Se recorded at the IS location were higher than those at the TIS station...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28314195/treatment-of-contaminated-greywater-using-pelletised-mine-water-sludge
#9
Suhail N Abed, Suhad A Almuktar, Miklas Scholz
Precipitated sludge (ochre) obtained from a mine water treatment plant was considered as an adsorbent substance for pollutants, since ochre is relatively free from problematic levels of toxic elements, which could impair on the quality of water to be treated. Artificially created ochre pellets from mixing Portland cement with raw ochre sludge were utilised to remediate either high (HC) or low (LC) contaminated synthetic greywater (SGW) in mesocosm-scale stabilisation ponds at 2-day and 7-day contact times under real weather conditions in Salford...
March 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28306152/assessment-of-ex-vivo-transport-function-in-isolated-rodent-brain-capillaries
#10
Gary N Y Chan, Ronald E Cannon
The blood-brain barrier plays an important role in neuroprotection; however, it can be a major obstacle for drug delivery to the brain. This barrier primarily resides in the brain capillaries and functions as an interface between the brain and peripheral blood circulation. Several anatomical and biochemical elements of the blood-brain barrier are essential to regulate the permeability of nutrients, ions, hormones, toxic metabolites, and xenobiotics into and out of the brain. In particular, high expression of ATP-driven efflux transporters at the blood-brain barrier is a major obstacle in the delivery of CNS pharmacotherapeutics to the brain...
March 17, 2017: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/28304072/dealing-with-iron-metabolism-in-rice-from-breeding-for-stress-tolerance-to-biofortification
#11
Railson Schreinert Dos Santos, Artur Teixeira de Araujo, Camila Pegoraro, Antonio Costa de Oliveira
Iron is a well-known metal. Used by humankind since ancient times in many different ways, this element is present in all living organisms, where, unfortunately, it represents a two-way problem. Being an essential block in the composition of different proteins and metabolic pathways, iron is a vital component for animals and plants. That is why iron deficiency has a severe impact on the lives of different organisms, including humans, becoming a major concern, especially in developing countries where access to adequate nutrition is still difficult...
March 16, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28303511/macro-and-microelement-status-in-animal-and-human-hypertension-the-role-of-the-ace-gene-i-d-polymorphism
#12
Olena Pavlyushchik, Viktor Afonin, Svetlana Fatykhava, Polina Shabunya, Viktoryia Sarokina, Aliaksandr Khapaliuk
Genetic factors that predispose to hypertension may contribute to element disturbances observed in hypertensive patients. We tested the hypothesis that the deletion allele of the angiotensin-converting enzyme (ACE) gene is associated with element imbalances in hypertension. The concentrations of elements in genetically predisposed to hypertension rats (SHRs) and their controls (WKY rats) were also examined. ICP-MS was used for elemental analysis of human hair and animal fur. Genotyping was performed by PCR...
March 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28303424/inherited-disorders-of-transition-metal-metabolism-an-update
#13
REVIEW
Peter T Clayton
Elements with a biological role include six trace transition metals: manganese, iron, cobalt, copper, zinc and molybdenum. Transition metals participate in group transfer reactions such as glycosylation and phosphorylation and those that can transfer an electron by alternating between two redox states such as iron (3+/2+) and copper (2+/1+) are also very important in biological redox reactions including the reduction of molecular oxygen and the transport of oxygen. However, these trace metals are also potentially toxic, generating reactive oxygen species through Fenton chemistry...
March 16, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28302590/stable-isotope-analysis-of-dynamic-lipidomics
#14
Joost Brandsma, Andrew P Bailey, Grielof Koster, Alex P Gould, Anthony D Postle
Metabolic pathway flux is a fundamental element of biological activity, which can be quantified using a variety of mass spectrometric techniques to monitor incorporation of stable isotope-labelled substrates into metabolic products. This article contrasts developments in electrospray ionisation mass spectrometry (ESI-MS) for the measurement of lipid metabolism with more established gas chromatography mass spectrometry and isotope ratio mass spectrometry methodologies. ESI-MS combined with diagnostic tandem MS/MS scans permits the sensitive and specific analysis of stable isotope-labelled substrates into intact lipid molecular species without the requirement for lipid hydrolysis and derivatisation...
March 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28302014/role-of-hepcidin-25-in-chronic-kidney-disease-anemia-and-beyond
#15
Norishi Ueda, Kazuya Takasawa
Iron is an essential element for all living organisms, but produces toxic oxidants. Thus, iron homeostasis is tightly regulated in mammals. Hepcidin-25 (hepcidin) has emerged as a molecule that regulates iron metabolism. Binding of hepcidin to its receptor, ferroportin, inhibits intestinal iron absorption and iron efflux from hepatocytes and macrophages. Decreased hepcidin enhances iron absorption and efflux. Hepcidin could be predictive of iron status and the response to iron supplementation or erythropoietin-stimulating agents...
March 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28301478/retrotransposon-activation-contributes-to-neurodegeneration-in-a-drosophila-tdp-43-model-of-als
#16
Lisa Krug, Nabanita Chatterjee, Rebeca Borges-Monroy, Stephen Hearn, Wen-Wei Liao, Kathleen Morrill, Lisa Prazak, Nikolay Rozhkov, Delphine Theodorou, Molly Hammell, Josh Dubnau
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43), an aggregation-prone RNA and DNA binding protein, is observed in the vast majority of both familial and sporadic ALS cases and in ~40% of FTLD cases, but the cascade of events leading to cell death are not understood...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28300784/the-molecular-basis-of-toxins-interactions-with-intracellular-signaling-via-discrete-portals
#17
REVIEW
Adi Lahiani, Ephraim Yavin, Philip Lazarovici
An understanding of the molecular mechanisms by which microbial, plant or animal-secreted toxins exert their action provides the most important element for assessment of human health risks and opens new insights into therapies addressing a plethora of pathologies, ranging from neurological disorders to cancer, using toxinomimetic agents. Recently, molecular and cellular biology dissecting tools have provided a wealth of information on the action of these diverse toxins, yet, an integrated framework to explain their selective toxicity is still lacking...
March 16, 2017: Toxins
https://www.readbyqxmd.com/read/28300779/valorization-of-phosphorus-secondary-raw-materials-by-acidithiobacillus-ferrooxidans
#18
Małgorzata Wyciszkiewicz, Agnieszka Saeid, Przemysław Malinowski, Katarzyna Chojnacka
This paper presents the possibility of producing phosphorus fertilizers through Acidithiobacillus ferrooxidans utilization in secondary raw materials solubilization. Phosphorus was obtained from the bones of poultry and fish as well as from Morocco phosphorite. Four doses of poultry bones and fish bones were used in the experiment (2, 4, 10 and 20 g/L) and two doses (2 and 4 g/L) of phosphorite were also used. The experimenters measured the final pH, which increased in proportion to the increase in the number of poultry bone doses, whereas in the case of fish bones it decreased in proportion to the increase in the number of fish bone doses...
March 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28299516/effects-of-nitrogen-and-water-addition-on-trace-element-stoichiometry-in-five-grassland-species
#19
Jiangping Cai, Jacob Weiner, Ruzhen Wang, Wentao Luo, Yongyong Zhang, Heyong Liu, Zhuwen Xu, Hui Li, Yuge Zhang, Yong Jiang
A 9-year manipulative experiment with nitrogen (N) and water addition, simulating increasing N deposition and changing precipitation regime, was conducted to investigate the bioavailability of trace elements, iron (Fe), manganese (Mn), copper (Cu), and zinc (Zn) in soil, and their uptake by plants under the two environmental change factors in a semi-arid grassland of Inner Mongolia. We measured concentrations of trace elements in soil and in foliage of five common herbaceous species including 3 forbs and 2 grasses...
March 15, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28296986/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-standard-reporting-and-evaluation-guidelines-results-of-a-national-institutes-of-health-working-group
#20
Emanual Maverakis, Elizabeth A Wang, Kanade Shinkai, Surakameth Mahasirimongkol, David J Margolis, Mark Avigan, Wen-Hung Chung, Jennifer Goldman, Lois La Grenade, Munir Pirmohamed, Neil H Shear, Wichittra Tassaeeyakul, Wolfram Hoetzenecker, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Wiparat Manuyakorn, Sally Usdin Yasuda, Victoria R Sharon, Andrea Sukhov, Robert Micheletti, Jeff Struewing, Lars E French, Michelle Y Cheng
Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are rare, acute, life-threatening dermatologic disorders involving the skin and mucous membranes. Research into these conditions is hampered by a lack of standardization of case reporting and data collection. Objective: To establish a standardized case report form to facilitate comparisons and maintain data quality based on an international panel of SJS/TEN experts who performed a Delphi consensus-building exercise...
March 15, 2017: JAMA Dermatology
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