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https://www.readbyqxmd.com/read/27915147/highly-sensitive-optical-interferometric-technique-reveals-stress-dependent-instantaneous-nanometric-growth-fluctuations-of-chinese-chive-leaf-under-heavy-metal-stress
#1
Kokge Thilini Kanchana Muthumali DeSilva, Uma Maheswari Rajagopalan, Hirofumi Kadono
Plant growth apart from being a complex and highly dynamic is dependent on its immediate environment. Leaf expansion measurements using Statistical Interferometry Technique, a sensitive interferometric technique at nanometric accuracy and at sub-second levels revealed the presence of characteristic nanometric intrinsic fluctuations [Plant Biotechnology 31, 195 (2014)]. In this paper, we demonstrate that the nanometric intrinsic fluctuations are sensitive enough that they change under exposure of heavy metals, essential micronutrient zinc and non-essential element cadmium, at relatively low concentrations in the leaves of Chinese chive (Allium tuberosum)...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27915140/two-zinc-aminoclays-in-vitro-cytotoxicity-assessment-in-hela-cells-and-in-vivo-embryotoxicity-assay-in-zebrafish
#2
Hang-Suk Chun, Duckshin Park, Song Eun Lim, Kwang-Hun Jeong, Ji-Seon Park, Han-Jin Park, Shinyoung Kang, Kyoung Suk Kang, Hyun Gyu Park, Ha-Rim An, Yun Suk Huh, Young-Chul Lee
Two zinc-aminoclays [ZnACs] with functionalized primary amines [(-CH2)3NH2] were prepared by a simple sol-gel reaction using cationic metal precursors of ZnCl2 and Zn(NO3)2 with 3-aminopropyl triethoxysilane [APTES] under ambient conditions. Due to the facile interaction of heavy metals with primary amine sites and Zn-related intrinsic antimicrobial activity, toxicity assays of ZnACs nanoparticles (NPs) prior to their environmental and human-health applications are essential. However, such reports remain rare...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27914288/the-use-of-red-mud-as-an-immobiliser-for-metal-metalloid-contaminated-soil-a-review
#3
REVIEW
Yumei Hua, Kate V Heal, Wolfgang Friesl-Hanl
This review focuses on the applicability of red mud as an amendment for metal/metalloid-contaminated soil. The varying properties of red muds from different sources are presented as they influence the potentially toxic element (PTE) concentration in amended soil. Experiments conducted worldwide from the laboratory to the field scale are screened and the influencing parameters and processes in soils are highlighted. Overall red mud amendment is likely to contribute to lowering the PTE availability in contaminated soil...
November 28, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27913532/t-cell-acute-lymphoblastic-leukemia
#4
Elizabeth A Raetz, David T Teachey
T-cell acute lymphoblastic leukemia (T-ALL) is biologically distinct from its B lymphoblastic (B-ALL) counterpart and shows different kinetic patterns of disease response. Although very similar regimens are used to treat T-ALL and B-ALL, distinctions in response to different elements of therapy have been observed. Similar to B-ALL, the key prognostic determinant in T-ALL is minimal residual disease (MRD) response. Unlike B-ALL, other factors including age, white blood cell count at diagnosis, and genetics of the ALL blasts are not independently prognostic when MRD response is included...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913115/computer-design-synthesis-and-bioactivity-analyses-of-drugs-like-fingolimod-used-in-the-treatment-of-multiple-sclerosis
#5
Gurbet Çelik Turgut, Doğukan Doyduk, Yılmaz Yıldırır, Serkan Yavuz, Atilla Akdemir, Ali Dişli, Alaattin Şen
Multiple sclerosis (MS) is a very common disease of vital importance. In the MS treatment, some drugs such as fingolimod which help to protect nerves from damage are used. The main goal of the drug therapy in MS is to take control of the inflammation which leads to the destruction of myelin and axons in nerve cell and thus prevent and stop the progression of the disease. Fingolimod (FTY720) is an orally active immunomodulatory drug that has been used for the treatment of relapsing-remitting multiple sclerosis...
November 18, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27910884/the-hha-tomb-toxin-antitoxin-system-shows-conditional-toxicity-and-promotes-persister-cell-formation-by-inhibiting-apoptosis-like-death-in-s-typhimurium
#6
Sangeeta Jaiswal, Prajita Paul, Chandrashekhar Padhi, Shilpa Ray, Daniel Ryan, Shantoshini Dash, Mrutyunjay Suar
Toxin-antitoxin (TA) modules are two component "addictive" genetic elements found on either plasmid or bacterial chromosome, sometimes on both. TA systems perform a wide range of functions like biofilm formation, persistence, programmed cell death, phage abortive infection etc. Salmonella has been reported to contain several such TA systems. However, the hemolysin expression modulating protein (Hha) and its adjacent uncharacterized hypothetical protein TomB (previously known as YbaJ), have not been listed as a TA module in Salmonella...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908426/environmental-exposures-of-trace-elements-assessed-using-keratinized-matrices-from-patients-with-chronic-kidney-diseases-of-uncertain-etiology-ckdu-in-sri-lanka
#7
Saranga Diyabalanage, Sanjeewani Fonseka, D M S N B Dasanayake, Rohana Chandrajith
An alarming increase in chronic kidney disease with unknown etiology (CKDu) has recently been reported in several provinces in Sri Lanka and chronic exposures to toxic trace elements were blamed for the etiology of this disease. Keratinized matrices such as hair and nails were investigated to determine the possible link between CKDu and toxic element exposures. Elements Li, B, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Hg and Pb of hair and nails of patients and age that matched healthy controls were determined with Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908424/first-comprehensive-study-on-total-contents-and-hot-water-extractable-fraction-of-selected-elements-in-19-medicinal-plants-from-various-locations-in-nyamira-county-kenya
#8
Volker Nischwitz, Richard Mogwasi, Salim Zor, Zachary Getenga, David K Kariuki, Klaus Günther
A large number of medicinal plants is traditionally known in Kenya and used for treatment of various diseases, for example diabetes, where metals are supposed to be involved in pathogenesis and therapy. Therefore, detailed investigation of the concentration of a large number of metals in medicinal plants is required for improved understanding and optimisation of the therapeutic role of metals and also to exclude potentially toxic effects. Our study focused on the determination of 30 selected elements in 19 medicinal plant species each collected from 3 sampling locations in Nyamira County, Kenya...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908406/trace-element-biomonitoring-in-hair-of-school-children-from-a-polluted-area-by-sector-field-inductively-coupled-plasma-mass-spectrometry
#9
Evgenii J Drobyshev, Nikolay D Solovyev, Natalya B Ivanenko, Maria Yu Kombarova, Alexander A Ganeev
In the current study, a biomonitoring of 18 hair trace elements (Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, V, Zn, Ca, Na and P) in school children from Leningradskaya Oblast' is reported. A case group, residing in a proximity to the toxic waste disposal grounds (Krasniy Bor), has been assessed vs. controls from a non-urban settlement Seltso. In total, 166 hair samples were analysed using double focusing sector field inductively coupled plasma mass spectrometry after microwave-assisted sample digestion with nitric acid...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908405/biosynthesis-of-selenium-nanoparticles-using-enterococcus-faecalis-and-evaluation-of-their-antibacterial-activities
#10
Sara Shoeibi, Mohammad Mashreghi
Microorganisms are capable of synthesizing metal nanoparticles, and specifically Enterococcus faecalis bacteria were tested for its ability to synthesize selenium nanoparticles (Se-NPs) from sodium selenite. The biosynthesized Se-NPs were spherical in shape with the size range of 29-195nm. Also, the TEM microscopy showed the accumulation of nano-structures as extracellular deposits. The ability of the bacteria to tolerate high levels of toxic selenite was studied by changing with different concentrations of sodium selenite (0...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27902938/functional-components-of-the-bacterial-czccba-efflux-system-reduce-cadmium-uptake-and-accumulation-in-transgenic-tobacco-plants
#11
Andrea Nesler, Giovanni DalCorso, Elisa Fasani, Anna Manara, Gian Pietro Di Sansebastiano, Emanuele Argese, Antonella Furini
Cadmium (Cd) is a toxic trace element released into the environment by industrial and agricultural practices, threatening the health of plants and contaminating the food/feed chain. Biotechnology can be used to develop plant varieties with a higher capacity for Cd accumulation (for use in phytoremediation programs) or a lower capacity for Cd accumulation (to reduce Cd levels in food and feed). Here we generated transgenic tobacco plants expressing components of the Pseudomonas putida CzcCBA efflux system. Plants were transformed with combinations of the CzcC, CzcB and CzcA genes, and the impact on Cd mobilization was analysed...
November 27, 2016: New Biotechnology
https://www.readbyqxmd.com/read/27902436/exploring-the-parameters-of-post-segregation-killing-using-heterologous-expression-of-secreted-toxin-barnase-and-antitoxin-barstar-in-an-e-coli-case-study
#12
Dorien S Coray, Brigitta Kurenbach, Jack A Heinemann
Post-segregational killing (PSK) is a phenotype determined by plasmids using a toxin and an antitoxin (TA) gene pair. Loss of the genes depletes the cell's reserve of antitoxin and allows the toxin to act upon the cell. PSK benefits mobile elements when it increases reproductive success relative to other mobile competitors. A side effect of PSK is that plasmids become refractory to displacement from the cell during growth as a monoculture. Most PSK systems use a cytoplasmic toxin, but the external toxins of bacteriocins also have a PSK-like effect...
November 16, 2016: Microbiology
https://www.readbyqxmd.com/read/27901227/evaluation-of-cytotoxicity-and-corrosion-resistance-of-orthodontic-mini-implants
#13
Celha Borges Costa Alves, Márcio Nunes Segurado, Miriam Cristina Leandro Dorta, Fátima Ribeiro Dias, Maurício Guilherme Lenza, Marcos Augusto Lenza
Objective: To evaluate and compare in vitro cytotoxicity and corrosion resistance of mini-implants from three different commercial brands used for orthodontic anchorage. Methods: Six mini-implants (Conexão(tm), Neodent(tm) and SIN(tm)) were separately immersed in artificial saliva (pH 6.76) for 30 and 60 days. The cytotoxicity of the corrosion extracts was assessed in L929 cell cultures using the violet crystal and MTT assays, as well as cell morphology under light microscopy...
September 2016: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/27899761/rehabilitation-augments-hematoma-clearance-and-attenuates-oxidative-injury-and-ion-dyshomeostasis-after-brain-hemorrhage
#14
Michael R Williamson, Kristen Dietrich, Mark J Hackett, Sally Caine, Colby A Nadeau, Jasmine R Aziz, Helen Nichol, Phyllis G Paterson, Frederick Colbourne
BACKGROUND AND PURPOSE: We assessed the elemental and biochemical effects of rehabilitation after intracerebral hemorrhage, with emphasis on iron-mediated oxidative stress, using a novel multimodal biospectroscopic imaging approach. METHODS: Collagenase-induced striatal hemorrhage was produced in rats that were randomized to enriched rehabilitation or control intervention starting on day 7. Animals were euthanized on day 14 or 21, a period of ongoing cell death...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27899269/pixe-study-on-the-effects-of-parathyroid-hormone-on-elemental-content-in-rat-bones
#15
M H Eisa, H Shen, W Jin, Abdulaziz S Alaamer, M A Al-Rajhi, Hajo Idriss
Parathyroid hormone (PTH) has attracted considerable interest as a bone anabolic agent. PTH plays a central role in regulating calcium phosphate metabolism and its increases in production in response to low serum calcium levels. A continuous hypersecretion of PTH, as occurs in primary hyperparathyroidism, leads to bone resorption. In this study, the effect of different doses of parathyroid hormone (PTH) on bone mineral content (BMC) in rats was investigated by particle-induced X-ray emission (PIXE). This study will help in investigating further the toxicity of extremely high doses of PTH on BMC...
November 26, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27898779/production-of-biomass-crops-using-biowastes-on-low-fertility-soil-1-influence-of-biowastes-on-plant-and-soil-quality
#16
J Esperschuetz, C Anderson, S Bulman, O Lense, J Horswell, N Dickinson, R Hofmann, B H Robinson
Land application of biosolids to low-fertility soil can improve soil quality by increasing concentrations of macronutrients and trace elements. Mixing biosolids with sawdust could reduce the risks of contaminant accumulation posed by rebuilding soils using biosolids alone. We aimed to determine the effects of biosolids and biosolids-sawdust on the plant quality and chemical composition of sorghum, rapeseed, and ryegrass. Plants were grown in a greenhouse over a 5-mo period in a low-fertility soil amended with biosolids (1250 kg N ha), biosolids-sawdust (0...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27895098/brain-aluminium-accumulation-and-oxidative-stress-in-the-presence-of-calcium-silicate-dental-cements
#17
K Demirkaya, B Can Demirdöğen, Z Öncel Torun, O Erdem, E Çırak, Y M Tunca
Mineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27891370/trace-elements-in-chronic-haemodialysis-patients-and-healthy-individuals-a-comparative-study
#18
Lokesh Shanmugam, Siva Ranganathan Green, Hemachandar Radhakrishnan, Tony Mathew Kadavanu, Arunkumar Ramachandrappa, Shashank Rakesh Tiwari, Amirtha Lakshmi Rajkumar, Ezhumalai Govindasamy
INTRODUCTION: End Stage Renal Disease (ESRD) patients despite receiving adequate Haemodialysis (HD) develop significant risk of Cardiovascular Disease (CVD). Abnormality in levels of trace elements may potentiate vascular injury by producing sustained inflammation and endothelial dysfunction. Hence, the present study was undertaken to evaluate the levels of trace elements in patients receiving HD. AIM: To study the blood levels of arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium among ESRD patients undergoing HD and compare it with healthy individuals...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891329/effects-of-lead-in-various-preparatory-stages-of-nagabhasma-on-function-and-histopathology-of-cornu-ammonis-of-hippocampus
#19
Lydia S Quadros, Hemalatha Bangera, Sushma R Kotian, Kumar M R Bhat
INTRODUCTION: Heavy metals are frequently used in the preparations of traditional/folk medicines. One such preparation in Ayurveda is Nagabhasma, in which lead is the main ingredient. Lead is non-essential element to the human body and is known toxic substance to many organ systems. However, it is claimed that, the highly toxic metallic lead will be converted into health beneficial organo-metallic compound when raw lead is subjected to various traditional methods of purification during preparation as mentioned in the ancient medicinal system...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889456/synthesis-of-new-morpholine-connected-pyrazolidine-derivatives-and-their-antimicrobial-antioxidant-and-cytotoxic-activities
#20
Radhakrishnan Surendra Kumar, Meera Moydeen, Salem S Al-Deyab, Aseer Manilal, Akbar Idhayadhulla
A simple and convenient one-pot four-component synthesis of morpholine-connected pyrazolidine derivatives 2a-f and 4a-f was developed using direct metal-free catalysis, with the identities of the synthesized compounds confirmed by IR, NMR ((1)H and (13)C), mass spectrometry, and elemental analysis. The prepared compounds were inspected for antimicrobial, antioxidant, and cytotoxic activities. Antimicrobial and antifungal activities against five bacterial and four fungal pathogens, respectively, were investigated using the disc diffusion technique...
November 14, 2016: Bioorganic & Medicinal Chemistry Letters
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