keyword
MENU ▼
Read by QxMD icon Read
search

veterinary toxicology

keyword
https://www.readbyqxmd.com/read/28641507/the-acvp-stp-coalition-for-veterinary-pathology-fellows-celebrates-32-new-training-positions
#1
Gary Cockerell, Cory Brayton, Anne Barger, Brad Bolon
Since its creation in 2004, the Coalition for Veterinary Pathology Fellows, a partnership between the American College of Veterinary Pathologists and the Society of Toxicologic Pathology, has established 32 new training positions backed by US$7.4 million in financial support from private sponsors.
June 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28583045/recommendations-for-clinical-pathology-data-generation-interpretation-and-reporting-in-target-animal-safety-studies-for-veterinary-drug-development
#2
William Siska, Aradhana Gupta, Lindsay Tomlinson, Niraj Tripathi, Barbara von Beust
Clinical pathology testing is routinely performed in target animal safety studies in order to identify potential toxicity associated with administration of an investigational veterinary pharmaceutical product. Regulatory and other testing guidelines that address such studies provide recommendations for clinical pathology testing but occasionally contain outdated analytes and do not take into account interspecies physiologic differences that affect the practical selection of appropriate clinical pathology tests...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28575422/fatalities-involving-carfentanil-and-furanyl-fentanyl-two-case-reports
#3
Dina M Swanson, Laura S Hair, Selly R Strauch Rivers, Brianna C Smyth, Sara C Brogan, Alexis D Ventoso, Samantha L Vaccaro, Julia M Pearson
Carfentanil is a fentanyl analog frequently used in large animal veterinary medicine. Recently, carfentanil has been discovered in postmortem and antemortem cases throughout the United States in the heroin supply either alone or mixed with heroin and/or other fentanyl analogs. The potency of carfentanil is ~10,000 times greater than morphine and 100 times greater than fentanyl. In two recent cases, carfentanil was identified and ruled to be the cause of death, either alone or in combination with other drugs...
May 31, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28535123/topical-otic-drugs-in-a-multi-purpose-manufacturing-facility-a-guide-on-determination-and-application-of-permitted-daily-exposure-pde
#4
Lisa Wiesner, Maarten Prause, Ester Lovsin Barle
Due to newly introduced EU GMP (Good Manufacturing Practice) guideline for Medicinal Products for Human and Veterinary use, product specific permitted daily exposure (PDE) for toxicological evaluation in multi-purpose facilities are required within a documented process for risk assessment. European Medicines Agency (EMA) guidance on setting PDE limits so far focused on systemic administration routes such as intravenous (IV), oral or inhalation. This article provides guidance on setting PDE values for risk management purposes in multi-purpose facilities for active pharmaceutical ingredients (APIs) applied as topical otic drugs to the outer ear canal...
June 7, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28487118/pittosporum-viridiflorum-sims-pittosporaceae-a-review-on-a-useful-medicinal-plant-native-to-south-africa-and-tropical-africa
#5
REVIEW
B Madikizela, L J McGaw
ETHNOPHARMACOLOGICAL RELEVANCE: Pittosporum viridiflorum Sims, a Pittosporaceae species, is used extensively in African traditional medicine (ATM) by various tribes. This review is an appraisal of the information concerning the description, distribution, conservation status, traditional uses, phytochemistry, pharmacology and toxicology of this species with the aim of reconciling it with its traditional use. MATERIALS AND METHODS: A wide-ranging literature search was conducted using database platforms such as Scopus, Google Scholar, Web of Science, ScienceDirect, PubMed and books including local reports and thesis submissions...
May 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28479392/relationship-between-ivermectin-concentrations-at-the-injection-site-muscle-and-fat-of-steers-treated-with-traditional-and-long-acting-preparations
#6
Sebastian Iezzi, Peter Purslow, Christensen Sara, Carlos Lanusse, Adrian Lifschitz
Ivermectin (IVM) is broad-spectrum compound active against endo and ecto-parasites of clinical relevance in veterinary and human medicine. It is commercially available to use in livestock animals as injectable formulations containing 1% IVM and also as a concentrated (3.15%) long-acting (LA) preparation. The potential risk of the presence of high concentrations of drug residues in muscle tissue at the injection site is therefore a concern. The aim of this study was to determine the relationship between the IVM residual concentrations at the injection site, in comparison to the untreated contralateral neck (control muscle) and in fat from cattle treated with different preparations...
May 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28406359/enantioselective-analysis-of-chloramphenicol-residues-in-honey-samples-by-chiral-lc-ms-ms-and-results-of-a-honey-survey
#7
Gerhard G Rimkus, Dirk Hoffmann
Chloramphenicol (CAP) is a broad-spectrum antibiotic used widely in both human and veterinary medication. Since 1994, CAP has not been authorised for use in food-producing animals in the European Union due to several adverse effects. A minimum required performance level (MRPL) of 0.3 µg kg(-)(1) was established in 2003. The CAP molecule contains two asymmetric centres, thus in total four para-CAP stereoisomers exist. Only the RR-CAP enantiomer is bioactive, having significant antimicrobial activity. For the first time a chiral LC-MS/MS method is reported to identify and quantify the four CAP enantiomers at residue levels in honey samples...
May 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28375070/teaching-tip-improving-students-email-communication-through-an-integrated-writing-assignment-in-a-third-year-toxicology-course
#8
April A Kedrowicz, Sarah Hammond, David C Dorman
Client communication is important for success in veterinary practice, with written communication being an important means for veterinarian-client information sharing. Effective communication is adapted to clients' needs and wants, and presents information in a clear, understandable manner while accounting for varying degrees of client health literacy. This teaching tip describes the use of a mock electronic mail assignment as one way to integrate writing into a required veterinary toxicology course. As part of this project, we provide baseline data relating to students' written communication that will guide further development of writing modules in other curricula...
April 4, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28372226/multiresidue-determination-of-veterinary-medicines-in-lyophilized-egg-albumen-with-subsequent-consumer-exposure-evaluation
#9
Marta Piątkowska, Małgorzata Gbylik-Sikorska, Anna Gajda, Piotr Jedziniak, Tomasz Błądek, Jan Żmudzki, Andrzej Posyniak
The process of lyophilization causes that the veterinary drugs residues present in egg albumen do not decompose, as it takes place during the process of high-temperature drying. Thus, lyophilized albumen may be a potential source of their residues for consumers. As a consequence, reliable methods for the determination of veterinary medicinal products from egg albumen are needed. The method for the determination of 85 analytes in lyophilized egg albumen was developed and successfully validated. The recoveries were between 84 and 110%, within laboratory repeatability and reproducibility - in the range of 3...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28235786/systematic-account-of-animal-poisonings-in-germany-2012-2015
#10
S E McFarland, R H Mischke, C Hopster-Iversen, X von Krueger, H Ammer, H Potschka, A Stürer, K Begemann, H Desel, M Greiner
A systematic retrospective study on animal poisonings in Germany (wildlife excluded) between January 2012 and December 2015 was conducted. Data were collected on animal exposure calls to German poison centres, poisoning cases presenting to the University of Veterinary Medicine, Hannover Small Animal and Equine Clinics, cases involving off-label use of veterinary medicinal products reported to the Federal Office of Consumer Protection and Food Safety and toxicological submissions to the Institute of Pharmacology, Toxicology, and Pharmacy, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich...
April 1, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28056663/principles-for-assessing-adversity-in-toxicologic-clinical-pathology
#11
Lila Ramaiah, Lindsay Tomlinson, Niraj K Tripathi, Laura C Cregar, Allison Vitsky, Barbara von Beust, Valerie G Barlow, William J Reagan, Daniela Ennulat
There is limited direction in the literature or regulatory guidance on determination of adversity for clinical pathology (CP) biomarkers in preclinical safety studies. Toxicologic clinical pathologists representing the American Society for Veterinary Clinical Pathology-Regulatory Affairs Committee and Society of Toxicologic Pathology-Clinical Pathology Interest Group identified principles, overall approach, and unique considerations for assessing adversity in CP data interpretation to provide a consensus opinion...
February 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28007369/pentobarbital-in-the-context-of-possible-suicides-analysis-of-a-case
#12
Paula Melo, Pedro Costa, Maria José Quintas, André Castro, Sónia Tarelho, João Miguel Franco, Helena M Teixeira
Pentobarbital is a barbiturate, acting as a central nervous system depressant (CNS), being used for its anticonvulsant, sedative, hypnotic and anaesthetic properties. Barbiturates were replaced by benzodiazepines, leading to a decrease in poisoning cases with these compounds. However, pentobarbital is still used in many countries as an anaesthetic in veterinary medicine. Due to its properties, this compound is sought after by people who wish to commit suicide, acquiring it on the black market. The authors present an unusual fatal pentobarbital intoxication case, in a 37 years-old male salesperson, with no known connection with the veterinary field, being more difficult to obtain this compound...
May 2017: Forensic Science International
https://www.readbyqxmd.com/read/27974078/operation-canine-lifeline-recommendations-for-enhancing-prehospital-care-for-government-working-dogs
#13
Teija Corse, Chelsea Firth, John Burke, Kenneth Schor, James F Koterski, Sabrina McGraw, Nancy Vincent-Johnson, Lori Gordon
Operation Canine Lifeline was a tabletop exercise developed by students and faculty of Boston University School of Medicine's Healthcare Emergency Management master's program. The tabletop exercise led to discussion on current protocols for canines working in the field, what occurs if a canine encounters a toxin in the field, and what to do in situations of national security that require working with civilian agencies. This discussion led to the creation of a set of recommendations around providing prehospital veterinary care to government working dogs...
December 15, 2016: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/27871899/balkan-endemic-nephropathy-still-continuing-enigma-risk-assessment-and-underestimated-hazard-of-joint-mycotoxin-exposure-of-animals-or-humans
#14
REVIEW
Stoycho D Stoev
The spreading of mycotoxic nephropathy in animals/humans was studied. The possible etiological causes provoking this nephropathy were carefully reviewed and analyzed. The natural content of the most frequent nephrotoxic mycotoxins in target feedstuffs/foods were investigated, in addition to their significance for development of renal damages in endemic areas. An estimation of the level of exposure of humans to the nephrotoxic mycotoxin, ochratoxin A (OTA), is made. The possible synergism or additive effects between some target mycotoxins in the development of nephropathy is also covered...
January 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27862218/toxicity-of-individual-pharmaceuticals-and-their-mixtures-to-aliivibrio-fischeri-evidence-of-toxicological-interactions-in-binary-combinations
#15
Valeria Di Nica, Sara Villa, Antonio Finizio
The combined toxicities of binary mixtures of veterinary pharmaceutical active compounds were examined using the bioluminescent bacterium Aliivibrio fischeri as a test organism (Microtox® test). Mixtures were prepared at an equitoxic ratio that corresponded to the inhibitory concentration, 10% (IC10) of individual pharmaceutical active compounds. In addition, the toxicity was determined of a multicomponent mixture that contained all of the investigated pharmaceutical active compounds mixed at a ratio corresponding to their individual predicted no-effect concentration (PNEC) values...
March 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27717067/one-health-transdisciplinary-opportunities-for-setac-leadership-in-integrating-and-improving-the-health-of-people-animals-and-the-environment
#16
REVIEW
A Alonso Aguirre, Val R Beasley, Tom Augspurger, William H Benson, Janet Whaley, Niladri Basu
One Health is a collaborative, transdisciplinary effort working locally, nationally, and globally to improve health for people, animals, plants, and the environment. The term is relatively new (from ∼2003), and it is increasingly common to see One Health included by name in interinstitutional research partnerships, conferences, communications, and organizational frameworks, particularly those championed by the human health and veterinary medical communities. Environmental quality is arguably the least developed component within the One Health framework, but can be guided by expertise within the Society of Environmental Toxicology and Chemistry (SETAC)...
October 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27679801/perspectives-in-veterinary-pharmacology-and-toxicology
#17
EDITORIAL
Arturo Anadón
No abstract text is available yet for this article.
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27677079/effects-of-in-vitro-and-in-vivo-avermectin-exposure-on-alpha-synuclein-expression-and-proteasomal-activity-in-pigeons
#18
Ming Li, Shuo Zhou, Xian-Song Wang, Ci Liu, Shu Li
Avermectins (AVMs) are used worldwide in agriculture and veterinary medicine. Residues of avermectin drugs, causing toxicological effects on non-target organisms, have raised great concern. The aim of this study was to investigate the effects of AVM on the expression levels of alpha synuclein (α-Syn) and proteasomal activity in pigeon (Columba livia) neurons both in vivo and in vitro. The results showed that, the mRNA and protein levels of α-Syn increased in AVM treated groups relative to control groups in the cerebrum, cerebellum and optic lobe in vivo...
January 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27643517/fipronil-insecticide-toxicology-oxidative-stress-and-metabolism
#19
Xu Wang, María Aránzazu Martínez, Qinghua Wu, Irma Ares, María Rosa Martínez-Larrañaga, Arturo Anadón, Zonghui Yuan
Fipronil (FIP) is widely used across the world as a broad-spectrum phenylpyrazole insecticide and veterinary drug. FIP was the insecticide to act by targeting the γ-aminobutyric acid (GABA) receptor and has favorable selective toxicity towards insects rather than mammals. However, because of accidental exposure, incorrect use of FIP or widespread FIP use leading to the contamination of water and soil, there is increasing evidence that FIP could cause a variety of toxic effects on animals and humans, such as neurotoxic, hepatotoxic, nephrotoxic, reproductive, and cytotoxic effects on vertebrate and invertebrates...
November 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27616733/animal-serial-killing-the-first-criminal-conviction-for-animal-cruelty-in-brazil
#20
Fernanda Auciello Salvagni, Adriana de Siqueira, Andre Rinaldi Fukushima, Marina Frota de Albuquerque Landi, Heidi Ponge-Ferreira, Paulo Cesar Maiorka
Animal cruelty is a known behavior of psychopaths, and although the serial killing of humans is widely acknowledged worldwide, this type of crime against animals is seldom discussed. This report describes the necropsy and toxicological findings of 37 dogs and cats, which were found dead in plastic bags in Sao Paulo, Brazil. The animals had all been in the care of an alleged animal rescuer and were to be referred for adoption before being found dead. In the necropsy, the animals showed varying degrees of putrefaction, indicating different periods of death, as well as single or multiple perforations on the thorax...
October 2016: Forensic Science International
keyword
keyword
86463
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"