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James Maxwell

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https://www.readbyqxmd.com/read/28500077/alternative-start-sites-downstream-of-nonsense-mutations-drive-antigen-presentation-and-tolerance-induction-to-c-terminal-epitopes
#1
Scott N Ashley, Suryanarayan Somanathan, Christian Hinderer, Maxwell Arias, Deirdre McMenamin, Christine Draper, James M Wilson
CTL responses to the transgene product remain an active area of concern for the gene therapy field. A patient's underlying genetic mutation may influence the qualitative nature of these potentially destructive T cell responses. Individuals with a mutation that introduces a premature termination codon (PTC) that prevents synthesis of the full-length peptide are considered more likely to mount a transgene-specific T cell response because of a lack of immune tolerance to C-terminal epitopes as a consequence of absent endogenous Ag presentation...
May 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28495554/collecting-duct-carcinoma-of-the-kidney-disease-characteristics-and-treatment-outcomes-from-the-national-cancer-database
#2
Wilson Sui, Justin T Matulay, Dennis J Robins, Maxwell B James, Ifeanyi C Onyeji, Arindam RoyChoudhury, Sven Wenske, Guarionex Joel DeCastro
OBJECTIVE: To use a large population-level database to assess survival outcomes for collecting duct renal cell carcinoma (CDRCC). MATERIALS AND METHODS: The National Cancer Database was queried for all cases of CDRCC and clear cell renal cell carcinoma (CCRCC) from 2004 to 2013. After removing patients with other cancer diagnoses, the analytic cohort was composed of 201,686 CCRCC and 577 CDRCC cases. Kaplan-Meier and cox proportional hazards analysis were employed to model survival...
May 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28486332/short-term-heat-acclimation-and-precooling-independently-and-combined-improve-5-km-running-performance-in-the-heat
#3
C A James, A J Richardson, A G B Willmott, P W Watt, O R Gibson, N S Maxwell
Following heat acclimation (HA), endurance running performance remains impaired in hot vs temperate conditions. Combining HA with precooling demonstrates no additive benefit in intermittent sprint, or continuous cycling exercise protocols, during which heat strain may be less severe compared to endurance running. This study investigated the effect of short-term heat acclimation (STHA) combined with mixed-methods precooling, on endurance running performance and directly compared precooling and HA. Nine amateur trained runners completed 5 km treadmill time trials in the heat (32°C, 60% RH) under four conditions; no intervention (CON), precooling (PC), short-term heat acclimation (5 days - HA) and short-term heat acclimation with precooling (HA+PC)...
May 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28433444/risk-of-ocular-hypertension-in-adults-with-noninfectious-uveitis
#4
Ebenezer Daniel, Maxwell Pistilli, Srishti Kothari, Naira Khachatryan, R Oktay Kaçmaz, Sapna S Gangaputra, H Nida Sen, Eric B Suhler, Jennifer E Thorne, C Stephen Foster, Douglas A Jabs, Robert B Nussenblatt, James T Rosenbaum, Grace A Levy-Clarke, Nirali P Bhatt, John H Kempen
PURPOSE: To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN: Retrospective, multicenter, cohort study. PARTICIPANTS: Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics. METHODS: Demographic, ocular, and treatment data were extracted from medical records of uveitis cases. MAIN OUTCOME MEASURES: Prevalent and incident OHT with intraocular pressures (IOPs) of ≥21 mmHg, ≥30 mmHg, and increase of ≥10 mmHg from documented IOP recordings (or use of treatment for OHT)...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28414690/injectable-biological-treatments-for-osteoarthritis-of-the-knee
#5
Maxwell E Weinberg, Daniel James Kaplan, Hien Pham, David Goodwin, Andrew Dold, Ernest Chiu, Laith M Jazrawi
No abstract text is available yet for this article.
April 21, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/28396182/safety-of-mesh-use-in-vaginal-cystocele-repair-analysis-of-national-patient-characteristics-and-complications
#6
Marissa C Theofanides, Ifeanyi Onyeji, Justin Matulay, Wilson Sui, Maxwell James, Doreen E Chung
PURPOSE: The use of mesh in vaginal cystocele repair has declined. We analyzed the American College of Surgeons National Surgical Quality Improvement Project (NSQIP) database to compare outcomes of repairs with and without mesh. MATERIALS AND METHODS: Current Procedural Terminology was used to identify patients undergoing cystocele repair with and without mesh from 2006-2013. Patient characteristics and complications were analyzed. RESULTS: 6,849 patients were identified...
April 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28318945/identification-and-structure-activity-relationships-of-quinoline-tertiary-alcohol-modulators-of-ror%C3%AE-t
#7
David A Kummer, Maxwell D Cummings, Marta Abad, Joseph Barbay, Glenda Castro, Ronald Wolin, Kevin D Kreutter, Umar Maharoof, Cynthia Milligan, Rachel Nishimura, Joan Pierce, Celine Schalk-Hihi, John Spurlino, Maud Urbanski, Hariharan Venkatesan, Aihua Wang, Craig Woods, Xiaohua Xue, James P Edwards, Anne M Fourie, Kristi Leonard
A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alcohol hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.
May 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28302652/the-entpd1-promoter-polymorphism-860-a-g-rs3814159-is-associated-with-increased-gene-transcription-protein-expression-cd39-ntpdase1-enzymatic-activity-and-thromboembolism-risk
#8
James P Maloney, Brian R Branchford, Gary L Brodsky, Maxwell S Cosmic, David W Calabrese, Christina L Aquilante, Kelly W Maloney, Joseph R Gonzalez, Weiming Zhang, Kerrie L Moreau, Kerri L Wiggins, Nicholas L Smith, Ulrich Broeckel, Jorge Di Paola
Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1) degrades the purines ATP and ADP that are key regulators of inflammation and clotting. We hypothesized that NTPDase1 polymorphisms exist and that they regulate this pathway. We sequenced the ENTPD1 gene (encoding NTPDase1) in 216 subjects then assessed genotypes in 2 cohorts comprising 2213 humans to identify ENTPD1 polymorphisms associated with venous thromboembolism (VTE). The G allele of the intron 1 polymorphism rs3176891 was more common in VTE vs...
March 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28273333/global-mammal-parasite-database-version-2-0
#9
Patrick R Stephens, Paula Pappalardo, Shan Huang, James E Byers, Maxwell J Farrell, Alyssa Gehman, Ria R Ghai, Sarah E Haas, Barbara Han, Andrew W Park, John P Schmidt, Sonia Altizer, Vanessa O Ezenwa, Charles L Nunn
Illuminating the ecological and evolutionary dynamics of parasites is one of the most pressing issues facing modern science, and is critical for basic science, the global economy and human health. Extremely important to this effort are data on the disease-causing organisms of wild animal hosts (including viruses, bacteria, protozoa, helminths, arthropods and fungi). Here we present an updated version of the Global Mammal Parasite Database, a database of the parasites of wild ungulates (artiodactyls and perissodactyls), carnivores, and primates, and make it available for download as complete flat files...
March 8, 2017: Ecology
https://www.readbyqxmd.com/read/28261218/the-t-cell-response-to-the-contact-sensitizer-paraphenylenediamine-is-characterized-by-a-polyclonal-diverse-repertoire-of-antigen-specific-receptors
#10
Theres Oakes, Amy Lee Popple, Jason Williams, Katharine Best, James M Heather, Mazlina Ismail, Gavin Maxwell, Nichola Gellatly, Rebecca J Dearman, Ian Kimber, Benny Chain
Paraphenylenediamine (PPD) is a common component of hair dyes and black henna tattoos and can cause skin sensitization and allergic contact dermatitis (ACD). The cutaneous inflammatory reaction associated with ACD is driven by both CD4+ and CD8+ T cells. However, the characteristics of such responses with respect to clonal breadth and magnitude are poorly defined. In this study, we have characterized the in vitro recall response of peripheral blood T cells prepared from PPD-allergic individuals to a PPD-human serum albumin (HSA) conjugate (PPD-HSA)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28246083/commissioning-of-specialist-palliative-care-services-in-england
#11
Harriet Lancaster, Ilora Finlay, Maxwell Downman, James Dumas
OBJECTIVES: Some failures in end-of-life care have been attributed to inconsistent provision of palliative care across England. We aimed to explore the variation in commissioning of services by Clinical Commissioning Groups (CCGs) using a data collection exercise. METHODS: We sent a Freedom of Information request in the form of an open questionnaire to all 209 CCGs in England to assess their commissioning of palliative and end-of-life care services, mainly focused on the provision of specialist palliative care services...
February 28, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28177747/short-term-heat-acclimation-improves-the-determinants-of-endurance-performance-and-5-km-running-performance-in-the-heat
#12
Carl A James, Alan J Richardson, Peter W Watt, Ashley G B Willmott, Oliver R Gibson, Neil S Maxwell
This study investigated the effect of 5 days of controlled short-term heat acclimation (STHA) on the determinants of endurance performance and 5-km performance in runners, relative to the impairment afforded by moderate heat stress. A control group (CON), matched for total work and power output (2.7 W·kg(-1)), differentiated thermal and exercise contributions of STHA on exercise performance. Seventeen participants (10 STHA, 7 CON) completed graded exercise tests (GXTs) in cool (13 °C, 50% relative humidity (RH), pre-training) and hot conditions (32 °C, 60% RH, pre- and post-training), as well as 5-km time trials (TTs) in the heat, pre- and post-training...
March 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28141966/past-present-and-future-of-integrated-control-of-apple-pests-the-new-zealand-experience
#13
James T S Walker, David Maxwell Suckling, C Howard Wearing
This review describes the New Zealand apple industry's progression from 1960s integrated pest control research to today's comprehensive integrated pest management system. With the exception of integrated mite control implemented during the 1980s, pest control on apple crops was dominated by intensive organophosphate insecticide regimes to control tortricid leafrollers. Multiple pest resistances to these insecticides by the 1990s, and increasing consumer demand for lower pesticide residues on fruit, led to the implementation of integrated fruit production...
January 31, 2017: Annual Review of Entomology
https://www.readbyqxmd.com/read/28126925/muc1-mediated-induction-of-myeloid-derived-suppressor-cells-in-patients-with-acute-myeloid-leukemia
#14
Athalia Rachel Pyzer, Dina Stroopinsky, Hasan Rajabi, Abigail Washington, Ashujit Tagde, Maxwell Coll, Jacqueline Fung, Mary Paty Bryant, Leandra Cole, Kristen Palmer, Poorvi Somaiya, Rebecca Karp Leaf, Myrna Nahas, Arie Apel, Salvia Jain, Malgorzata McMasters, Lourdes Mendez, James Levine, Robin Joyce, Jon Arnason, Pier Paolo Pandolfi, Donald Kufe, Jacalyn Rosenblatt, David Avigan
Myeloid-derived suppressor cells (MDSCs) play a critical role in promoting immune tolerance and disease growth. The mechanism by which tumor cells evoke the expansion of MDSCs in Acute Myeloid Leukemia (AML) has not been well described. We have demonstrated that patients with AML exhibit increased presence of MDSCs in their peripheral blood, compared to normal controls. Cytogenetic studies demonstrated that MDSCs in patients with AML may be derived from leukemic or apparently normal progenitors. Engraftment of C57BL/6 mice with TIB-49 AML led to an expansion of CD11b+ Gr1+ MDSCs in bone marrow and spleen...
January 26, 2017: Blood
https://www.readbyqxmd.com/read/28103613/tissue-based-next-generation-sequencing-application-in-a-universal-healthcare-system
#15
REVIEW
Seán O Hynes, Brendan Pang, Jacqueline A James, Perry Maxwell, Manuel Salto-Tellez
In the context of solid tumours, the evolution of cancer therapies to more targeted and nuanced approaches has led to the impetus for personalised medicine. The targets for these therapies are largely based on the driving genetic mutations of the tumours. To track these multiple driving mutations the use of next generation sequencing (NGS) coupled with a morphomolecular approach to tumours, has the potential to deliver on the promises of personalised medicine. A review of NGS and its application in a universal healthcare (UHC) setting is undertaken as the technology has a wide appeal and utility in diagnostic, clinical trial and research paradigms...
February 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28040248/dramatic-increase-in-mud-distribution-across-a-large-sub-tropical-embayment-moreton-bay-australia
#16
James R Lockington, Simon Albert, Paul L Fisher, Badin R Gibbes, Paul S Maxwell, Alistair R Grinham
Major flood events can dramatically alter the coastal sediment environment. This study established the current sediment distribution in a large sub-tropical embayment, Moreton Bay, Australia, and examined the effect of three recent floods on modifying this distribution. In 2015, surface sediment samples were collected from 223 sites across the study area and analysed for particle size distribution with the resultant sediment distribution mapped. In addition, sampling of flood waters during two major events in 2011 and 2013 was undertaken and particle size distribution of suspended sediment was determined...
March 15, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28035322/micropapillary-bladder-cancer-insights-from-the-national-cancer-database
#17
Wilson Sui, Justin T Matulay, Maxwell B James, Ifeanyi C Onyeji, Marissa C Theofanides, Arindam RoyChoudhury, G Joel DeCastro, Sven Wenske
Introduction: Micropapillary bladder cancer (MPBC) is a variant histology of urothelial carcinoma (UC) that is associated with poor outcomes however given its rarity, little is known outside of institutional reports. We sought to use a population-level cancer database to assess survival outcomes in patients treated with surgery, radiation therapy and/or chemotherapy. Materials and Methods: The National Cancer Database (NCDB) was queried for all cases of MPBC and UC using International Classification of Disease-O-3 morphologic codes between 2004-2014...
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/27982637/magnetorotational-turbulence-and-dynamo-in-a-collisionless-plasma
#18
Matthew W Kunz, James M Stone, Eliot Quataert
We present results from the first 3D kinetic numerical simulation of magnetorotational turbulence and dynamo, using the local shearing-box model of a collisionless accretion disk. The kinetic magnetorotational instability grows from a subthermal magnetic field having zero net flux over the computational domain to generate self-sustained turbulence and outward angular-momentum transport. Significant Maxwell and Reynolds stresses are accompanied by comparable viscous stresses produced by field-aligned ion pressure anisotropy, which is regulated primarily by the mirror and ion-cyclotron instabilities through particle trapping and pitch-angle scattering...
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27935427/short-term-heat-acclimation-prior-to-a-multi-day-desert-ultra-marathon-improves-physiological-and-psychological-responses-without-compromising-immune-status
#19
Ashley G B Willmott, Mark Hayes, Kirsty A M Waldock, Rebecca L Relf, Emily R Watkins, Carl A James, Oliver R Gibson, Nicholas J Smeeton, Alan J Richardson, Peter W Watt, Neil S Maxwell
Multistage, ultra-endurance events in hot, humid conditions necessitate thermal adaptation, often achieved through short term heat acclimation (STHA), to improve performance by reducing thermoregulatory strain and perceptions of heat stress. This study investigated the physiological, perceptual and immunological responses to STHA prior to the Marathon des Sables. Eight athletes (age 42 ± 4 years and body mass 81.9 ± 15.0 kg) completed 4 days of controlled hyperthermia STHA (60 min·day(‒1), 45°C and 30% relative humidity)...
December 9, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27928494/synthetically-tuneable-biomimetic-artificial-photosynthetic-reaction-centres-that-closely-resemble-the-natural-system-in-purple-bacteria
#20
Sai-Ho Lee, Iain M Blake, Allan G Larsen, James A McDonald, Kei Ohkubo, Shunichi Fukuzumi, Jeffrey R Reimers, Maxwell J Crossley
Porphyrin-based photosynthetic reaction centre (PRC) mimics, ZnPQ-Q2HP-C60 and MP2Q-Q2HP-C60 (M = Zn or 2H), designed to have a similar special-pair electron donor and similar charge-separation distances, redox processes and photochemical reaction rates to those in the natural PRC from purple bacteria, have been synthesised and extensive photochemical studies performed. Mechanisms of electron-transfer reactions are fully investigated using femtosecond and nanosecond transient absorption spectroscopy. In benzonitrile, all models show picosecond-timescale charge-separations and the final singlet charge-separations with the microsecond-timescale...
October 19, 2016: Chemical Science
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