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James Maxwell

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https://www.readbyqxmd.com/read/28989775/celebrating-30-years-of-science-from-the-james-clerk-maxwell-telescope
#1
REVIEW
Ian Robson, Wayne S Holland, Per Friberg
The James Clerk Maxwell Telescope (JCMT) has been the world's most successful single-dish telescope at submillimetre wavelengths since it began operations in 1987. From the pioneering days of single-element photometers and mixers, through to the state-of-the-art imaging and spectroscopic cameras, the JCMT has been associated with a number of major scientific discoveries. Famous for the discovery of 'SCUBA' galaxies, which are responsible for a large fraction of the far-infrared background, the JCMT has pushed the sensitivity limits arguably more than any other facility in this most difficult of wavebands in which to observe...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28945127/efficacy-of-the-early-administration-of-valacyclovir-hydrochloride-for-the-treatment-of-neuropathogenic-equine-herpesvirus-type-1-infection-in-horses
#2
Lara K Maxwell, Bradford G Bentz, Lyndi L Gilliam, Jerry W Ritchey, Nicola Pusterla, R Eberle, Todd C Holbrook, Dianne McFarlane, Grant B Rezabek, James Meinkoth, Chase Whitfield, Carla L Goad, George P Allen
OBJECTIVE To determine whether prophylactic administration of valacyclovir hydrochloride versus initiation of treatment at the onset of fever would differentially protect horses from viral replication and clinical disease attributable to equine herpesvirus type-1 (EHV-1) infection. ANIMALS 18 aged mares. PROCEDURES Horses were randomly assigned to receive an oral placebo (control), treatment at detection of fever, or prophylactic treatment (initiated 1 day prior to viral challenge) and then inoculated intranasally with a neuropathogenic strain of EHV-1...
October 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28944273/defining-the-determinants-of-endurance-running-performance-in-the-heat
#3
Carl A James, Mark Hayes, Ashley G B Willmott, Oliver R Gibson, Andreas D Flouris, Zachary J Schlader, Neil S Maxwell
In cool conditions, physiologic markers accurately predict endurance performance, but it is unclear whether thermal strain and perceived thermal strain modify the strength of these relationships. This study examined the relationships between traditional determinants of endurance performance and time to complete a 5-km time trial in the heat. Seventeen club runners completed graded exercise tests (GXT) in hot (GXTHOT; 32°C, 60% RH, 27.2°C WBGT) and cool conditions (GXTCOOL; 13°C, 50% RH, 9.3°C WBGT) to determine maximal oxygen uptake (V̇O2max), running economy (RE), velocity at V̇O2max (vV̇O2max), and running speeds corresponding to the lactate threshold (LT, 2 mmol...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28935363/seagrass-ecosystem-trajectory-depends-on-the-relative-timescales-of-resistance-recovery-and-disturbance
#4
Katherine R O'Brien, Michelle Waycott, Paul Maxwell, Gary A Kendrick, James W Udy, Angus J P Ferguson, Kieryn Kilminster, Peter Scanes, Len J McKenzie, Kathryn McMahon, Matthew P Adams, Jimena Samper-Villarreal, Catherine Collier, Mitchell Lyons, Peter J Mumby, Lynda Radke, Marjolijn J A Christianen, William C Dennison
Seagrass ecosystems are inherently dynamic, responding to environmental change across a range of scales. Habitat requirements of seagrass are well defined, but less is known about their ability to resist disturbance. Specific means of recovery after loss are particularly difficult to quantify. Here we assess the resistance and recovery capacity of 12 seagrass genera. We document four classic trajectories of degradation and recovery for seagrass ecosystems, illustrated with examples from around the world. Recovery can be rapid once conditions improve, but seagrass absence at landscape scales may persist for many decades, perpetuated by feedbacks and/or lack of seed or plant propagules to initiate recovery...
September 18, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28902780/is-multifocality-an-indicator-of-aggressive-behavior-in-small-bowel-neuroendocrine-tumors
#5
Allen B Choi, Jessica E Maxwell, Kendall J Keck, Andrew J Bellizzi, Joseph S Dillon, Thomas M OʼDorisio, James R Howe
OBJECTIVES: Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to determine the frequency of multifocal and unifocal SBNETs and compare clinicopathologic factors, somatostatin receptor 2 expression, and survival. METHODS: Clinicopathologic variables from 179 patients with surgically managed SBNETs were collected...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28853888/water-evaporation-from-acoustically-levitated-aqueous-solution-droplets
#6
Nicole A Combe, D James Donaldson
We present a systematic study of the effect of solutes on the evaporation rate of acoustically levitated aqueous solution droplets by suspending individual droplets in a zero-relative humidity environment and measuring their size as a function of time. The ratios of the early time evaporation rates of six simple salts (NaCl, NaBr, NaNO3, KCl, MgCl2, CaCl2) and malonic acid to that of water are in excellent agreement with predictions made by modifying the Maxwell equation to include the time-dependent water activity of the evaporating aqueous salt solution droplets...
September 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28820709/performance-of-a-high-sensitivity-rapid-diagnostic-test-for-plasmodium-falciparum-malaria-in-asymptomatic-individuals-from-uganda-and-myanmar-and-naive-human-challenge-infections
#7
Smita Das, Ihn Kyung Jang, Becky Barney, Roger Peck, John C Rek, Emmanuel Arinaitwe, Harriet Adrama, Maxwell Murphy, Mallika Imwong, Clare L Ling, Stephane Proux, Warat Haohankhunnatham, Melissa Rist, Annette M Seilie, Amelia Hanron, Glenda Daza, Ming Chang, Tomoka Nakamura, Michael Kalnoky, Paul Labarre, Sean C Murphy, James S McCarthy, Francois Nosten, Bryan Greenhouse, Sophie Allauzen, Gonzalo J Domingo
Sensitive field-deployable diagnostic tests can assist malaria programs in achieving elimination. The performance of a new Alere™ Malaria Ag P.f Ultra Sensitive rapid diagnostic test (uRDT) was compared with the currently available SD Bioline Malaria Ag P.f RDT in blood specimens from asymptomatic individuals in Nagongera, Uganda, and in a Karen Village, Myanmar, representative of high- and low-transmission areas, respectively, as well as in pretreatment specimens from study participants from four Plasmodium falciparum-induced blood-stage malaria (IBSM) studies...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28727837/differing-roles-for-short-chain-fatty-acids-and-gpr43-agonism-in-the-regulation-of-intestinal-barrier-function-and-immune-responses
#8
Warren N D'Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, Joseph R Maxwell, James B Rottman, Katja Labitzke, Angela Willee, Holger Beckmann, Yingcai Wang, Yang Li, Ralf Schwandner, James A Johnston, Jennifer E Towne, Hailing Hsu
Inflammatory bowel disease (IBD) is associated with a loss of intestinal barrier function and dysregulated immune responses. It has been shown that short chain fatty acids (SCFAs) are protective in IBD and that GPR43 mediates the protective effects of SCFAs. In this study, we investigated the effects of SCFAs in comparison to highly specific GPR43 agonists on human intestinal epithelial and immune cells. Our results confirm that SCFAs are enhancers of barrier function in intestinal epithelial cells. Additionally, SCFAs also displayed potent immunoregulatory properties based upon the ability to inhibit LPS-induced cytokine production in PBMC, and human T cell proliferation and cytokine production...
2017: PloS One
https://www.readbyqxmd.com/read/28724769/simian-t-lymphotropic-virus-1-infection-of-papio-anubis-tax-sequence-heterogeneity-and-t-cell-recognition
#9
James M Termini, Diogo M Magnani, Helen S Maxwell, William Lauer, Iris Castro, Jerilyn Pecotte, Glen N Barber, David I Watkins, Ronald C Desrosiers
Baboons naturally infected with simian T lymphotropic virus (STLV) are a potentially useful model system for the study of vaccination against human T lymphotropic virus (HTLV). Here we expanded the number of available full-length baboon STLV-1 sequences from one to three and related the T cell responses that recognize the immunodominant Tax protein to the tax sequences present in two individual baboons. Continuously growing T cell lines were established from two baboons, animals 12141 and 12752. Next-generation sequencing (NGS) of complete STLV genome sequences from these T cell lines revealed them to be closely related but distinct from each other and from the baboon STLV-1 sequence in the NCBI sequence database...
October 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28718214/a-boron-alkylidene-alkene-cycloaddition-reaction-application-to-the-synthesis-of-aphanamal
#10
Xun Liu, T Maxwell Deaton, Fredrik Haeffner, James P Morken
We describe an unusual net [2+2] cycloaddition reaction between boron alkylidenes and unactivated alkenes. This reaction provides a new method for the construction of carbocyclic ring systems bearing versatile organoboronic esters. Aside from surveying the scope of this reaction, we provide details about the mechanistic underpinnings of this process, and examine its application to the synthesis of the natural product aphanamal.
September 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28697717/timing-and-predictors-of-early-urologic-and-infectious-complications-after-renal-transplant-an-analysis-of-a-new-york-statewide-database
#11
Wilson Sui, Michael J Lipsky, Justin T Matulay, Dennis J Robins, Ifeanyi C Onyeji, Maxwell B James, Marissa C Theofanides, Sven Wenske
OBJECTIVES: The most common complications after renal transplant are urologic and are a cause of significant morbidity in a vulnerable population. We sought to characterize the timing and predictors of urologic complications after renal transplant using a statewide database. MATERIALS AND METHODS: We queried the New York Statewide Planning and Research Cooperative System database to identify patients who underwent renal transplant from 2005 to 2013. Postoperative complications included hydronephrosis, ureteral stricture, vesicoureteral reflux, nephrolithiasis, and urinary tract infections...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28684228/sling-procedures-for-the-treatment-of-stress-urinary-incontinence-comparison-of-national-practice-patterns-between-urologists-and-gynecologists
#12
Maxwell B James, Marissa C Theofanides, Wilson Sui, Ifeanyi Onyeji, Gina M Badalato, Doreen E Chung
PURPOSE: Sling procedures have become the dominant method of surgical management of stress urinary incontinence and are frequently performed by both urologists and gynecologists. Few studies investigating trends in surgical management have focused on differences in provision of care between the specialties. In this study, we sought to compare national practice patterns of sling procedures by provider type. MATERIALS & METHODS: We analyzed the 2006-2013 American College of Surgeons National Surgical Quality Improvement Program database...
July 3, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28649662/the-contribution-of-pathogenic-variants-in-breast-cancer-susceptibility-genes-to-familial-breast-cancer-risk
#13
Thomas P Slavin, Kara N Maxwell, Jenna Lilyquist, Joseph Vijai, Susan L Neuhausen, Steven N Hart, Vignesh Ravichandran, Tinu Thomas, Ann Maria, Danylo Villano, Kasmintan A Schrader, Raymond Moore, Chunling Hu, Bradley Wubbenhorst, Brandon M Wenz, Kurt D'Andrea, Mark E Robson, Paolo Peterlongo, Bernardo Bonanni, James M Ford, Judy E Garber, Susan M Domchek, Csilla Szabo, Kenneth Offit, Katherine L Nathanson, Jeffrey N Weitzel, Fergus J Couch
Understanding the gene-specific risks for development of breast cancer will lead to improved clinical care for those carrying germline mutations in cancer predisposition genes. We sought to detail the spectrum of mutations and refine risk estimates for known and proposed breast cancer susceptibility genes. Targeted massively-parallel sequencing was performed to identify mutations and copy number variants in 26 known or proposed breast cancer susceptibility genes in 2134 BRCA1/2-negative women with familial breast cancer (proband with breast cancer and a family history of breast or ovarian cancer) from a largely European-Caucasian multi-institutional cohort...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28596970/type-2-diabetes-in-young-females-results-in-increased-serum-amyloid-a-and-changes-to-features-of-high-density-lipoproteins-in-both-hdl2-and-hdl3
#14
Kayleigh Griffiths, Agnieszka Pazderska, Mohammed Ahmed, Anne McGowan, Alexander P Maxwell, Jane McEneny, James Gibney, Gareth J McKay
Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with T2DM (n = 42) and individuals without T2DM (n = 42). SAA and apolipoprotein AI (apoAI) concentrations, paraoxonase-1 (PON-1), cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) activities were measured in the serum and/or HDL2 and HDL3 subfractions...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28595259/molecular-profiling-of-signet-ring-cell-colorectal-cancer-provides-a-strong-rationale-for-genomic-targeted-and-immune-checkpoint-inhibitor-therapies
#15
Muhammad A Alvi, Maurice B Loughrey, Philip Dunne, Stephen McQuaid, Richard Turkington, Marc-Aurel Fuchs, Claire McGready, Victoria Bingham, Brendan Pang, Wendy Moore, Perry Maxwell, Mark Lawler, Jacqueline A James, Graeme I Murray, Richard H Wilson, Manuel Salto-Tellez
BACKGROUND: Signet ring cell colorectal cancer (SRCCa) has a bleak prognosis. Employing molecular pathology techniques we investigated the potential of precision medicine in this disease. METHODS: Using test (n=26) and validation (n=18) cohorts, analysis of mutations, DNA methylation and transcriptome was carried out. Microsatellite instability (MSI) status was established and immunohistochemistry (IHC) was used to test for adaptive immunity (CD3) and the immune checkpoint PDL1...
July 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28579407/detailed-investigation-into-the-cytogenetic-constitution-and-pregnancy-outcome-of-replacing-mosaic-blastocysts-detected-with-the-use-of-high-resolution-next-generation-sequencing
#16
Santiago Munné, Joshua Blazek, Michael Large, Pedro A Martinez-Ortiz, Haley Nisson, Emmeline Liu, Nicoletta Tarozzi, Andrea Borini, Amie Becker, John Zhang, Susan Maxwell, James Grifo, Dhruti Babariya, Dagan Wells, Elpida Fragouli
OBJECTIVE: To determine the pregnancy outcome potential of mosaic embryos, detected by means of preimplantation genetic screening (PGS) with the use of next-generation sequencing (NGS). DESIGN: Retrospective study. SETTING: Genetics laboratories. PATIENT(S): PGS cycles during which either mosaic or euploid embryos were replaced. INTERVENTION(S): Blastocysts were biopsied and processed with the use of NGS, followed by frozen embryo transfer...
July 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28560597/increased-grade-in-neuroendocrine-tumor-metastases-negatively-impacts-survival
#17
Kendall J Keck, Allen Choi, Jessica E Maxwell, Guiying Li, Thomas M O'Dorisio, Patrick Breheny, Andrew M Bellizzi, James R Howe
BACKGROUND: Tumor grade is an important predictor of survival in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs), as determined by Ki-67 expression and mitotic rate. NETs generally grow indolently, but some cells may acquire traits facilitating metastasis. It is unclear how frequently metastases differ in grade from their primary tumors, and whether increasing grade in metastases affects prognosis. METHODS: Ki-67 immunohistochemistry was performed on resected GEPNET specimens and cases with results for both primary tumors and concurrent metastases were identified...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28537398/discovery-of-clinical-candidate-2-2s-6s-2-phenyl-6-hydroxyadamantan-2-yl-1-3-hydroxyazetidin-1-yl-ethanone-bms-816336-an-orally-active-novel-selective-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor
#18
Xiang-Yang Ye, Stephanie Y Chen, Shung Wu, David S Yoon, Haixia Wang, Zhenqiu Hong, Stephen P O'Connor, Jun Li, James J Li, Lawrence J Kennedy, Steven J Walker, Akbar Nayeem, Steven Sheriff, Daniel M Camac, Vidyhashankar Ramamurthy, Paul E Morin, Rachel Zebo, Joseph R Taylor, Nathan N Morgan, Randolph P Ponticiello, Thomas Harrity, Atsu Apedo, Rajasree Golla, Ramakrishna Seethala, Mengmeng Wang, Timothy W Harper, Bogdan G Sleczka, Bin He, Mark Kirby, David K Leahy, Jianqing Li, Ronald L Hanson, Zhiwei Guo, Yi-Xin Li, John D DiMarco, Raymond Scaringe, Brad Maxwell, Frederick Moulin, Joel C Barrish, David A Gordon, Jeffrey A Robl
BMS-816336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identified as a novel, potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). 6n-2 exhibits a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50 0.12 mg/kg) and in DIO mice. It is orally bioavailable (%F ranges from 20 to 72% in preclinical species) and has a predicted pharmacokinetic profile of a high peak to trough ratio and short half-life in humans...
June 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28500077/alternative-start-sites-downstream-of-non-sense-mutations-drive-antigen-presentation-and-tolerance-induction-to-c-terminal-epitopes
#19
Scott N Ashley, Suryanarayan Somanathan, Christian Hinderer, Maxwell Arias, Deirdre McMenamin, Christine Draper, James M Wilson
CTL responses to the transgene product remain an active area of concern for the gene therapy field. A patient's underlying genetic mutation may influence the qualitative nature of these potentially destructive T cell responses. Individuals with a mutation that introduces a premature termination codon (PTC) that prevents synthesis of the full-length peptide are considered more likely to mount a transgene-specific T cell response because of a lack of immune tolerance to C-terminal epitopes as a consequence of absent endogenous Ag presentation...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28495554/collecting-duct-carcinoma-of-the-kidney-disease-characteristics-and-treatment-outcomes-from-the-national-cancer-database
#20
Wilson Sui, Justin T Matulay, Dennis J Robins, Maxwell B James, Ifeanyi C Onyeji, Arindam RoyChoudhury, Sven Wenske, Guarionex Joel DeCastro
OBJECTIVE: To use a large population-level database to assess survival outcomes for collecting duct renal cell carcinoma (CDRCC). MATERIALS AND METHODS: The National Cancer Database was queried for all cases of CDRCC and clear cell renal cell carcinoma (CCRCC) from 2004 to 2013. After removing patients with other cancer diagnoses, the analytic cohort was composed of 201,686 CCRCC and 577 CDRCC cases. Kaplan-Meier and cox proportional hazards analysis were employed to model survival...
September 2017: Urologic Oncology
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