keyword
MENU ▼
Read by QxMD icon Read
search

hematologic changes steroids

keyword
https://www.readbyqxmd.com/read/29066336/safety-investigation-on-total-steroid-saponins-extracts-from-dioscorea-zingiberensis-c-h-wright-sub-acute-and-chronic-toxicity-studies-on-dogs
#1
Xinxin Zhang, Ming Jin, Nigatu Tadesse, Liang Xian, Hui Zhang, Sicen Wang, Jun Dang, Yan Zhang, Zengjun Guo, Yoichiro Ito
Sub-acute and chronic toxic effects of total steroidal saponins (TSSN) extracts from Dioscorea zingiberensis C.H. Wright on various internal organs and biochemical indicators have never been studied before and this study is the first of its kind to demonstrate sub-acute and chronic toxicities of TSSN on dogs. Administration of TSSN extracts at doses up to 3000 mg/Kg daily for 14 days, no biochemical and organ changes were observed on the experimental groups of dogs. Further, chronic toxicity study through oral administration of TSSN extracts at the gradual doses of 50, 250 and 500 mg/Kg for 90 days followed by a 2-week recovery assay revealed absence of significant architectural and morphological changes in internal organs which were confirmed through histopathological examination and merely no significant alteration in the biochemical indicators including hematologic and urine analysis and electrocardiogram compared to the control dogs...
October 21, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28871936/xanthoma-like-skin-changes-in-an-elderly-woman-with-a-normal-lipid-profile
#2
Piotr Nockowski, Zdzisław Woźniak, Adam Reich, Joanna Maj
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Imaging assessment and ultrasound examination did not show any specific involvement of internal organs...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28811010/distinct-clinical-characteristics-of-paroxysmal-nocturnal-hemoglobinuria-in-patients-in-southern-taiwan-a-multicenter-investigation
#3
Hui-Ching Wang, Ching-Yuan Kuo, I-Ting Liu, Tsai-Yun Chen, Yu-Hsiang Chang, Shyh-Jer Lin, Shih-Feng Cho, Yi-Chang Liu, Ta-Chih Liu, Sheng-Fung Lin, Chao-Sung Chang
Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare acquired disorder. The aim of this study was to investigate the demographics, clinical manifestations, and outcomes of PNH patients in southern Taiwan. Data on PNH patients diagnosed over a 30-year period (1985-2015) were retrospectively collected from four tertiary medical centers in southern Taiwan. Blood samples were collected for hematologic panel testing and flow cytometry detection of PNH clones. Radiologic studies were performed to assess the frequency of complications...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28578329/the-athlete-biological-passport-how-to-personalize-anti-doping-testing-across-an-athlete-s-career
#4
Neil Robinson, Pierre-Edouard Sottas, Yorck Olaf Schumacher
For decades, drug testing has been the main instrument at the disposal of anti-doping authorities. The availability in the 1980s of substances identical to those produced by the human body, including the "big 3" (erythropoietin, testosterone, and growth hormone), necessitated a new paradigm in anti-doping. The athlete biological passport (ABP) is a new paradigm, complementary to traditional drug testing, based on the personalized monitoring of doping biomarkers. Athletes who abuse doping substances do so to trigger physiological changes that provide performance enhancement...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28531342/prognostic-significance-of-preoperative-neutrophilia-on-recurrence-free-survival-in-meningioma
#5
Shirin Karimi, Manav V Vyas, Lior Gonen, Raha Tabasinejad, Quinn T Ostrom, Jill Barnholtz-Sloan, Suganth Suppiah, Gelareh Zadeh, Kenneth Aldape
Background: Meningioma is the most common primary intracranial tumor and recurrence is one of the important challenges in patient management. Prognostic factors for tumor recurrences in these patients especially before surgical resection are not fully characterized. Several studies have indicated an association between changes in hematologic laboratory parameters with patient outcomes in solid malignancies. We aimed to assess the association between hematologic parameters and tumor recurrence in patients with meningioma...
October 19, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28469926/primary-hypertrophic-osteoarthropathy-due-to-a-novel-slco2a1-mutation-masquerading-as-acromegaly
#6
Ruth Mangupli, Adrian F Daly, Elvia Cuauro, Paul Camperos, Jaime Krivoy, Albert Beckers
SUMMARY: A 20-year-old man with an 8-year history of progressive enlargement of his hands and feet, coarsening facial features, painful joints and thickened, oily skin was referred for investigation of acromegaly. On examination, the subject was of normal height and weight. He had markedly increased skin thickness around the forehead, eyelids and scalp with redundant skin folds. Bilateral painful knee swelling was accompanied by enlargement of the extremities, and his fingers were markedly clubbed...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28399164/sequential-monitoring-of-lymphocyte-subsets-and-of-t-and-b-cell-neogenesis-indexes-to-identify-time-varying-immunologic-profiles-in-relation-to-graft-versus-host-disease-and-relapse-after-allogeneic-stem-cell-transplantation
#7
Cristina Skert, Simone Perucca, Marco Chiarini, Viviana Giustini, Alessandra Sottini, Claudia Ghidini, Stefano Martellos, Federica Cattina, Benedetta Rambaldi, Valeria Cancelli, Michele Malagola, Alessandro Turra, Nicola Polverelli, Simona Bernardi, Luisa Imberti, Domenico Russo
T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) and relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with B and T cell neogenesis indexes has been not thoroughly analysed in relation to these changing and interrelated immunologic/clinic events yet. Lymphocyte subsets in peripheral blood (PB) and B and T cell neogenesis indexes were analysed together at different time points in a prospective study of 50 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28314084/treatment-patterns-and-outcome-following-initial-relapse-or-refractory-disease-in-patients-with-systemic-light-chain-amyloidosis
#8
Nidhi Tandon, Surbhi Sidana, Morie A Gertz, Angela Dispenzieri, Martha Q Lacy, Francis K Buadi, David Dingli, Amie L Fonder, Miriam A Hobbs, Suzanne R Hayman, Wilson I Gonsalves, Yi Lisa Hwa, Prashant Kapoor, Robert A Kyle, Nelson Leung, Ronald S Go, John A Lust, Stephen J Russell, Steven R Zeldenrust, S Vincent Rajkumar, Shaji K Kumar
We analyzed the outcomes following initial relapse or refractory disease in systemic light chain amyloidosis (AL) and the impact of type of therapy employed.A total of 1327 patients with AL seen at Mayo Clinic within 90 days of diagnosis, between 2006 and 2015, were reviewed. The study included 366 patients experiencing a documented hematological or organ relapse or refractory disease requiring start of second line therapy. Overall survival (OS) and time to next treatment (TTNT) were calculated from start of second line treatment...
June 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28145788/preclinical-and-pharmacotoxicology-evaluation-of-%C3%AE-l-guluronic-acid-g2013-as-a-non-steroidal-anti-inflammatory-drug-with-immunomodulatory-property
#9
Sepideh Nazeri, Shahin Khadem Azarian, Mohammad Javad Fattahi, Reza Sedaghat, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Mohammad Abdollahi, Abbas Mirshafiey
CONTEXT: Therapeutic effects of α-l-guluronic acid with the greatest tolerability and efficacy (G2013) have been shown in experimental model of multiple sclerosis and other in vitro and in vivo examinations regarding α-l-guluronic acid; there are no toxicological researches on its safety although the pharmacological impacts have been recorded. OBJECTIVE: This study was designed to determine the acute and sub chronic toxicity of α-l-guluronic acid in healthy male and female BALB/c mice...
April 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28069354/bufadienolides-from-amphibians-a-promising-source-of-anticancer-prototypes-for-radical-innovation-apoptosis-triggering-and-na-k-atpase-inhibition
#10
REVIEW
Lívia Queiroz de Sousa, Kátia da Conceição Machado, Samara Ferreira de Carvalho Oliveira, Lidiane da Silva Araújo, Evaldo Dos Santos Monção-Filho, Ana Amélia de Carvalho Melo-Cavalcante, Gerardo Magela Vieira-Júnior, Paulo Michel Pinheiro Ferreira
Amphibians present pharmacologically active aliphatic, aromatic and heterocyclic molecules in their skin as defense against microorganisms, predators and infections, such as steroids, alkaloids, biogenic amines, guanidine derivatives, proteins and peptides. Based on the discovered bioactive potential of bufadienolides, this work reviewed the contribution of amphibians, especially from members of Bufonidae family, as source of new cytotoxic and antitumor molecules, highlighting the mechanisms responsible for such amazing biological potentialities...
March 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27628782/comparison-in-toxicity-and-solubilizing-capacity-of-hydroxypropyl-%C3%AE-cyclodextrin-with-different-degree-of-substitution
#11
COMPARATIVE STUDY
Pengyu Li, Jia Song, Xiaomin Ni, Qin Guo, Hui Wen, Qiuyun Zhou, Yuanna Shen, Yijun Huang, Pengxin Qiu, Suizhen Lin, Haiyan Hu
Hydroxypropyl-β-cyclodextrin (HP-β-CD) has been widely used as an effective solubilizing agent in pharmaceutical industry for many years. However, the effect of degree of substitution (D.S.) of HP-β-CD on solubilizing capacity and toxicity has not been concerned. In this study, solubilizing capacity of HP-β-CDs with three different D.S. (4.55, 6.16 and 7.76) for 16 drugs were measured and their toxicities were compared by a 7-day i.v. administration (q.d.) study in rats. Generally, HP-β-CD with high D...
November 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27598977/influence-of-the-use-of-testosterone-associated-with-physical-training-on-some-hematologic-and-physical-parameters-in-older-rats-with-alloxan-induced-diabetes
#12
Romeu Paulo Martins Silva, Rodrigo Otávio Dos Santos, Nelson Eurípedes Matildes, Antônio Vicente Mundim, Mario da Silva Garrote-Filho, Pâmella Ferreira Rodrigues, Nilson Penha-Silva
Objective: This study investigated the possible blood changes in wistar rats elderly with and without treatment with anabolic steroids submitted physical training. Materials and methods: Elderly rats (32) were divided into four groups: normal (N), treated normal (NT), diabetic (D) and treated diabetic (DT). They were submitted to 20 sessions of swimming with overload (5% body weight), 40 min/day for four weeks. The NT and DT groups received application of testosterone twice a week...
January 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27494223/prevalence-and-implications-of-abnormal-laboratory-results-in-patients-in-the-terminal-phase-of-life
#13
Anniek D Masman, Dick Tibboel, Frans P M Baar, Monique van Dijk, Ron A A Mathot, Teun van Gelder
BACKGROUND: Pathophysiological changes at the end of life may affect pharmacokinetics of drugs. However, caregivers typically do not extensively monitor patients' laboratory parameters at the end of life. OBJECTIVE: Our aim was to describe laboratory parameters of hospice patients in the week before death. METHODS: A cohort study was conducted on available laboratory results in the week before death, including clinical chemistry and hematology tests...
August 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27149134/adverse-reaction-to-cetuximab-an-epidermal-growth-factor-receptor-inhibitor
#14
Daška Štulhofer Buzina, Ivana Martinac, Daniela Ledić Drvar, Romana Čeović, Ivan Bilić, Branka Marinović
Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Papulopustular rash (acne like rash) develop with 80-86% patients receiving cetuximab, while xerosis, eczema, fissures, teleangiectasiae, hyperpigmentations, and nail and hair changes occur less frequently (2)...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/26992660/oral-administration-of-%C3%AE-carotene-or-lycopene-prevents-atopic-dermatitis-like-dermatitis-in-hr-1-mice
#15
Makiko Hiragun, Takaaki Hiragun, Ikumi Oseto, Kazue Uchida, Yuhki Yanase, Akio Tanaka, Tomoka Okame, Shingo Ishikawa, Shoji Mihara, Michihiro Hide
Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease. Certain populations of patients are resistant to standard therapies with topical steroids and/or calcineurin inhibitors, and require systemic medication, such as immunosuppressants. Recently, several reports have shed light on the anti-allergic effects of carotenoids. Therefore, we investigated the effect of p.o. administration of β-carotene or lycopene on AD-like symptoms of HR-1 hairless mice fed with a low zinc/magnesium diet. Mice were divided into four groups: (i) fed with a standard diet (Co group); (ii) low zinc/magnesium diet (HR group); (iii) low zinc/magnesium and β-carotene diet (HR-C group); and (iv) low zinc/magnesium and lycopene diet (HR-L group)...
October 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26584020/preclinical-assessment-of-%C3%AE-d-mannuronic-acid-m2000-as-a-non-steroidal-anti-inflammatory-drug
#16
Mohammad Javad Fattahi, Mohammad Abdollahi, Asghar Agha Mohammadi, Noushin Rastkari, Reza Khorasani, Hossein Ahmadi, Farzaneh Tofighi Zavareh, Reza Sedaghat, Nakisa Tabrizian, Abbas Mirshafiey
CONTEXT: β-d-Mannuronic acid (M2000) has shown its therapeutic effects with the greatest tolerability and efficacy in various experimental models such as experimental autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis. Despite pharmacological effects of β-D-mannuronic acid, there have been no systematic toxicological studies on its safety so far. OBJECTIVE: The study was designed to determine the acute and subchronic toxicity of β-D-mannuronic acid, an anti-inflammatory agent, in healthy male NMRI mice and Wistar rats, respectively...
2015: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/26469881/imaging-patterns-and-outcome-of-posterior-reversible-encephalopathy-syndrome-during-childhood-cancer-treatment
#17
Raja B Khan, Zsila S Sadighi, Jennifer Zabrowski, Amar Gajjar, Sima Jeha
BACKGROUND: Diagnosis of posterior reversible encephalopathy syndrome (PRES) requires presence of headache, seizures, impaired vision, or altered mentation accompanied by specific imaging findings. We aimed to study long-term clinical and radiologic outcome of PRES in children with cancer to augment limited available data. PROCEDURE: Retrospective review of children with cancer who were diagnosed with PRES. RESULTS: We identified PRES in 21 males and 16 females among 5,217 children treated during the study period...
March 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26363106/cytomegalovirus-enteritis-with-ischemia-in-an-immunocompetent-patient-a-rare-case-report
#18
Zainab Naseem, Rasika Hendahewa, Muslim Mustaev, Gamini Premaratne
INTRODUCTION: Cytomegalovirus (CMV) is predominantly an opportunistic infection in the immunocompromised patients. Though, there are few cases of CMV colitis being reported in the immunocompetent individuals, CMV enteritis is exceedingly rare and enteritis leading into small bowel ischemia has never been reported yet. PRESENTATION OF CASE: A-78-year-old male patient presented with distal small obstruction for 4 days duration. Clinical examination revealed a distended abdomen and localised peritonism in right iliac fossa...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26008639/the-interactions-between-diabetes-mellitus-and-myelodysplastic-syndromes-current-state-of-evidence-and-future-directions
#19
REVIEW
Eyad Hamoudeh, Amer M Zeidan, Lisa Barbarotta, Nina Rosano
Diabetes mellitus (DM) and cancer are disorders of global importance. Multiple epidemiologic studies show that diabetic patients have an increased risk of developing cancer of different types. Myelodysplastic syndromes (MDS) are among the most common hematologic malignancies and include a heterogeneous group of hematopoietic neoplasms characterized by dysplastic changes, low blood counts, and an increased risk of progression to acute myeloid leukemia. Potential epigenetic and metabolic interferences between DM and MDS have been reported but are poorly understood...
2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/25816623/-effect-of-polypeptides-isolated-from-cattle-abomasum-on-stomach-regenerative-processes-in-rats
#20
I M Chernukha, A N Bogatyrev, A S Dydykin, M A Aslanova, L V Fedulova
The effect of polypeptides isolated from cattle abomasum on regenerative processes of rat stomach upon simulating stomach mucosal damage caused by aspirin was studied. Experimental research was carried out on male Wistar rats with initial body weight of 230±20 g. The duration of the experiment was 22 days. The rats were divided into 4 equal groups (n=11). The first (control) group-consisted of the intact animals; animals from experimental groups 2-4 were intragastrically administered acetylsalicylic acid from the 1st to the 7th day for simulating stomach mucosal damage caused by aspirin (300 mg/100 g body weight)...
2014: Voprosy Pitaniia
keyword
keyword
86457
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"