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myocardial infarction 4a type

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https://www.readbyqxmd.com/read/27573032/optical-coherence-tomography-to-optimize-results-of-percutaneous-coronary-intervention-in-patients-with-non-st-elevation-acute-coronary-syndrome-results-of-the-multicenter-randomized-doctors-study-does-optical-coherence-tomography-optimize-results-of-stenting
#1
Nicolas Meneveau, Geraud Souteyrand, Pascal Motreff, Christophe Caussin, Nicolas Amabile, Patrick Ohlmann, Olivier Morel, Yoann Lefrançois, Vincent Descotes-Genon, Johanne Silvain, Nassim Braik, Romain Chopard, Marion Chatot, Fiona Ecarnot, Hélène Tauzin, Eric Van Belle, Loïc Belle, François Schiele
BACKGROUND: No randomized study has investigated the value of optical coherence tomography (OCT) in optimizing the results of percutaneous coronary intervention (PCI) for non-ST-segment elevation acute coronary syndromes. METHODS: We conducted a multicenter, randomized study involving 240 patients with non-ST-segment elevation acute coronary syndromes to compare OCT-guided PCI (use of OCT pre- and post-PCI; OCT-guided group) to fluoroscopy-guided PCI (angiography-guided group)...
September 27, 2016: Circulation
https://www.readbyqxmd.com/read/27535209/type-4a-myocardial-infarction-incidence-risk-factors-and-long-term-outcomes
#2
Xiaoyu Yang, Hector Tamez, Carol Lai, Kalon Ho, Donald Cutlip
OBJECTIVES: To assess the incidence of and outcomes related to periprocedural (Type 4a) myocardial infarction (MI) in a cohort of patients undergoing percutaneous coronary intervention (PCI) for stable coronary disease or non ST-elevation acute coronary syndrome with stable or falling cardiac troponin levels. BACKGROUND: The 2012 Third Universal Definition for Type 4a MI has not been prospectively studied in routine clinical practice. METHODS: The study included 516 patients undergoing eligible PCI at a single institution...
August 18, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27443475/elective-percutaneous-coronary-intervention-leads-to-significant-changes-in-serum-resistin-leptin-and-adiponectin-levels-regardless-of-periprocedural-myocardial-injury-an-observational-study
#3
Ali Buturak, Aleks Değirmencioğlu, Fatih Bayrak, Tuncay Kırış, Hüseyin Karakurt, Ali Rıza Demir, Özgür Sürgit, Mehmet Ertürk
OBJECTIVE: Bioactive roles of adipokines in coronary atherosclerosis and acute coronary syndromes have been demonstrated previously. However, there is a lack of data regarding the relationship between serum adipokines and periprocedural myocardial injury (PMI) following elective percutaneous coronary intervention (PCI). Therefore, we aimed to investigate the association between serum adipokines and PMI related to elective PCI. METHODS: In total, 153 consecutive patients (aged 60...
June 29, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27320428/coronary-angiography-related-myocardial-injury-as-detected-by-high-sensitivity-cardiac-troponin-t-assay
#4
Haitham Abu Sharar, Daniel Wohlleben, Mehrshad Vafaie, Arnt V Kristen, H Christian Volz, Raffi Bekeredjian, Hugo A Katus, Evangelos Giannitsis
AIMS: We sought to evaluate rates and mechanisms of myocardial injury and type 4a myocardial infarction (MI) after an elective diagnostic coronary angiography (CAG) as detected by high-sensitivity cardiac troponin T (hsTnT) assay. METHODS AND RESULTS: Cardiac troponin concentrations were measured in consecutive patients before and after undergoing an elective CAG -with or without coronary intervention (PCI)- using an hsTnT assay. The study population consisted of 545 patients: 320 (58...
June 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27228417/the-universal-2012-definition-of-myocardial-infarction-compared-to-the-2007-definition
#5
Jørund Langørgen, Marta Ebbing, Jannicke Igland, Jan Erik Nordrehaug, Stein Emil Vollset, Anne Kask, Grethe S Tell, Ottar Nygård
OBJECTIVES: The third Universal 2012 definition of myocardial infarction (MI) has not been compared to the Universal 2007 definition with regard to the number of cases identified, classification and mortality. DESIGN: We examined potential MI events according to the two universal definitions in 1494 patients admitted to the University hospital during the 12 months. Patients were included either because of an MI discharge diagnosis (815 patients) or due to elevated troponin I levels without an MI discharge diagnosis (679 patients)...
August 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/26966448/rise-of-serum-troponin-levels-following-uncomplicated-elective-percutaneous-coronary-interventions-in-patients-without-clinical-and-procedural-signs-suggestive-of-myocardial-necrosis
#6
Ali Buturak, Aleks Degirmencioglu, Ozgur Surgit, Ali Rıza Demir, Huseyin Karakurt, Mehmet Erturk, Selcuk Yazıcı, Mustafa Serteser, Tugrul Norgaz, Sevket Gorgulu
INTRODUCTION: The new definition of periprocedural myocardial infarction (type 4a MI) excludes patients without angina and electrocardiographic or echocardiographic changes suggestive of myocardial ischemia even though significant serum troponin elevations occur following percutaneous coronary intervention (PCI). AIM: To evaluate the incidence and predictors of serum troponin rise following elective PCI in patients without clinical and procedural signs suggestive of myocardial necrosis by using a high-sensitivite troponin assay (hsTnT)...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/26011261/efficacy-of-electroacupuncture-pretreatment-for-myocardial-injury-in-patients-undergoing-percutaneous-coronary-intervention-a-randomized-clinical-trial-with-a-2-year-follow-up
#7
RANDOMIZED CONTROLLED TRIAL
Qiang Wang, Dong Liang, Feng Wang, Weijie Li, Yaling Han, Wei Zhang, Yaning Xie, Weichuan Xin, Baili Zhou, Dongdong Sun, Feng Cao, Lize Xiong
Electroacupuncture pretreatment (EAP) safely protects the heart from ischemic injury, however, the efficacy of EAP for periprocedural myocardial injury after percutaneous coronary intervention (PCI) remains unclear. Our aim was to investigate whether EAP prior to PCI reduces post-PCI myocardial injury in patients with coronary artery disease (CAD). 388 patients (≥ 18 years old) with CAD, undergoing elective PCI were enrolled and randomized, out of those 204 went through the whole trial. EAP was conducted by 30-minute electrical stimulation through 4 electrodes attached to the Antiguan (PC6) and Ximen (PC4) acupoints in the forearm bilaterally 1-2h prior to PCI...
September 1, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25697382/prognostic-significance-of-peri-procedural-myocardial-infarction-in-the-era-of-high-sensitivity-troponin-a-validation-of-the-joint-accf-aha-esc-whf-universal-definition-of-type-4a-myocardial-infarction-with-high-sensitivity-troponin-t
#8
Kevin Liou, Nigel Jepson, Petrina Kellar, Ben Ng, Julia Isbister, Robert Giles, Daniel Friedman, Roger Allan, Antony Lau, Mark Pitney, Sze-Yuan Ooi
AIMS: This study aims to validate the joint ACCF/AHA/ESC/WHF Universal Definition of peri-procedural myocardial infarction (PMI) with high sensitivity troponin T (hsTnT). METHODS: A retrospective cohort study encompassing patients admitted to our institution between May 2012 and April 2013 was performed. RESULTS: 630 patients underwent percutaneous coronary interventions during the study period. Among them, 459 patients met the inclusion criteria and were eligible for analyses...
July 2015: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/25518514/-type-4a-myocardial-infarction
#9
REVIEW
O Iu Mironova
An increase in the level of cardiac troponins and creatine kinase MB is sometimes observed even after angiographically and clinically uncomplicated percutaneous coronary interventions. This review article deals with the clinical and prognostic implications of type 4a myocardial infarction.
2014: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/24793669/effect-of-one-cycle-remote-ischemic-preconditioning-to-reduce-myocardial-injury-during-percutaneous-coronary-intervention
#10
RANDOMIZED CONTROLLED TRIAL
Theodoros A Zografos, George D Katritsis, Ioannis Tsiafoutis, Nikolaos Bourboulis, Apostolos Katsivas, Demosthenes G Katritsis
Up to 1/3 of percutaneous coronary interventions (PCIs) are complicated by troponin release. Remote ischemic preconditioning (IPC) confers effective cardioprotection; however, a 30-minute remote IPC protocol may be difficult to implement during ad hoc PCI. This study was performed to assess the ability of a brief remote IPC protocol to attenuate cardiac troponin I (cTnI) release after ad hoc PCI. Ninety-four patients undergoing ad hoc PCI for stable coronary artery disease, with undetectable preprocedural cTnI, were recruited and randomized to receive remote IPC (induced by one 5-minute inflation of a blood pressure cuff to 200 mm Hg around the upper arm) or control after the decision for PCI was made...
June 15, 2014: American Journal of Cardiology
https://www.readbyqxmd.com/read/24163121/effect-of-remote-ischemic-preconditioning-in-the-elderly-patients-with-coronary-artery-disease-with-diabetes-mellitus-undergoing-elective-drug-eluting-stent-implantation
#11
RANDOMIZED CONTROLLED TRIAL
Xiaohan Xu, Yujie Zhou, Shengjie Luo, Weijun Zhang, Yingxin Zhao, Miao Yu, Qian Ma, Fei Gao, Hua Shen, Jianwei Zhang
There is conflicting evidence regarding the effectiveness of remote ischemic preconditioning (RIPC) in patients undergoing elective percutaneous coronary intervention (PCI). Therefore, we prospectively enrolled elderly patients with coronary heart disease (CHD) with diabetes mellitus (DM) undergoing elective drug-eluting stent (DES) implantation. They were randomized to receive RIPC within 2 hours before PCI (n = 102) or not (controls, n = 98). Baseline clinical characteristics were similar between the 2 groups...
September 2014: Angiology
https://www.readbyqxmd.com/read/24152063/relationship-between-time-of-day-and-periprocedural-myocardial-infarction-after-elective-angioplasty
#12
MULTICENTER STUDY
Stephane Fournier, Serban Puricel, Beata Morawiec, Eric Eeckhout, Fabio Mangiacapra, Catalina Trana, Maxime Tapponnier, Juan F Iglesias, Vincent Michiels, Jean-Christophe Stauffer, Ahmed Beggah, Pierre Monney, Stéphanie Gobet, Pierre Vogt, Stéphane Cook, Olivier Muller
OBJECTIVES: To test if the time of day significantly influences the occurrence of type 4A myocardial infarction in elective patients undergoing percutaneous coronary intervention (PCI). BACKGROUND: Recent studies have suggested an influence of circadian rhythms on myocardial infarction size and mortality among patients with ST-elevation myocardial infarction. The aim of the study is to investigate whether periprocedural myocardial infarction (PMI) is influenced by the time of day in elective patients undergoing PCI...
March 2014: Chronobiology International
https://www.readbyqxmd.com/read/24135581/consideration-of-a-new-definition-of-clinically-relevant-myocardial-infarction-after-coronary-revascularization-an-expert-consensus-document-from-the-society-for-cardiovascular-angiography-and-interventions-scai
#13
Issam D Moussa, Lloyd W Klein, Binita Shah, Roxana Mehran, Michael J Mack, Emmanouil S Brilakis, John P Reilly, Gilbert Zoghbi, Elizabeth Holper, Gregg W Stone
Numerous definitions have been proposed for the diagnosis of myocardial infarction (MI) after coronary revascularization. The universal definition for MI designates post procedural biomarker thresholds for defining percutaneous coronary intervention (PCI)-related MI (type 4a) and coronary artery bypass grafting (CABG)-related MI (type 5), which are of uncertain prognostic importance. In addition, for both the MI types, cTn is recommended as the biomarker of choice, the prognostic significance of which is less well validated than CK-MB...
October 22, 2013: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/24095258/polymorphisms-of-the-nos3-gene-and-risk-of-myocardial-infarction-in-the-tunisian-population
#14
Amani Kallel, Mohamed Hédi Sbaï, Yousra Sediri, Salem Abdessalem, Mohamed Sami Mourali, Moncef Feki, Rachid Mechmeche, Riadh Jemaa, Naziha Kaabachi
Controversial results regarding the association of eNOS gene (NOS3) polymorphisms with myocardial infarction (MI) have been reported. This study investigated the relationship of the -786T>C (rs2070744), 894G>T (rs1799983) and 4a4b polymorphisms of the NOS3 gene with the presence of MI in the Tunisian population. In addition, we also examined the association of NOS3 gene haplotypes with MI in Tunisian subjects. A total of 303 patients with MI and 225 controls were included in the study. The 894G>T and -786T>C single nucleotide polymorphisms were analyzed by PCR-RFLP, and 4a4b polymorphism just for PCR...
December 2013: Cytokine
https://www.readbyqxmd.com/read/23894025/consideration-of-a-new-definition-of-clinically-relevant-myocardial-infarction-after-coronary-revascularization-an-expert-consensus-document-from-the-society-for-cardiovascular-angiography-and-interventions-scai
#15
Issam D Moussa, Lloyd W Klein, Binita Shah, Roxana Mehran, Michael J Mack, Emmanouil S Brilakis, John P Reilly, Gilbert Zoghbi, Elizabeth Holper, Gregg W Stone
Numerous definitions have been proposed for the diagnosis of myocardial infarction (MI) after coronary revascularization. The universal definition for MI designates post procedural biomarker thresholds for defining percutaneous coronary intervention (PCI)-related MI (type 4a) and coronary artery bypass grafting (CABG)-related MI (type 5) which are of uncertain prognostic importance. In addition, for both MI types cTn is recommended as the biomarker of choice, the prognostic significance of which is less well validated than CK-MB...
January 1, 2014: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/23811833/evaluation-of-coronary-microvascular-function-and-nitric-oxide-synthase-intron-4a-b-polymorphism-in-patients-with-coronary-slow-flow
#16
Ahmet Ekmekci, Bariş Güngör, Kazim S Özcan, Neslihan Abaci, Erkan Ilhan, Sema S Ekmekci, Tuğba Kemaloğlu, Damirbek Osmonov, Duran Ustek, Mehmet Eren
OBJECTIVE: Slow coronary flow (SCF) is reported to be associated with increased risk of cardiovascular disease. We have used coronary flow reserve measurement by transthoracic Doppler echocardiography to determine coronary microvascular function in patients with SCF and to determine whether the intron 4a/b polymorphism of the eNOS gene influences coronary endothelial function. METHODS: Overall, 96 patients with SCF and 79 controls were enrolled in the study. Coronary flow was quantified according to the thrombolysis in myocardial infarction (TIMI) frame count (TFC) on angiogram...
September 2013: Coronary Artery Disease
https://www.readbyqxmd.com/read/23696599/remote-ischemic-preconditioning-improves-outcome-at-6-years-after-elective-percutaneous-coronary-intervention-the-crisp-stent-trial-long-term-follow-up
#17
RANDOMIZED CONTROLLED TRIAL
William R Davies, Adam J Brown, William Watson, Liam M McCormick, Nick E J West, David P Dutka, Stephen P Hoole
BACKGROUND: Postprocedural myocardial infarction (type 4a) has been shown to be an adverse prognostic indicator after elective percutaneous coronary intervention (PCI). The Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) study demonstrated that remote ischemic preconditioning reduced procedural symptoms, ECG ST-segment deviation, and cardiac troponin I release after elective PCI and reduced the major adverse cardiac and cerebral event (MACCE) rate at 6 months...
June 2013: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/23530022/effect-of-vorapaxar-on-myocardial-infarction-in-the-thrombin-receptor-antagonist-for-clinical-event-reduction-in-acute-coronary-syndrome-tra%C3%A2-cer-trial
#18
Sergio Leonardi, Pierluigi Tricoci, Harvey D White, Paul W Armstrong, Zhen Huang, Lars Wallentin, Philip E Aylward, David J Moliterno, Frans Van de Werf, Edmond Chen, Luis Providencia, Jan E Nordrehaug, Claes Held, John Strony, Tyrus L Rorick, Robert A Harrington, Kenneth W Mahaffey
AIMS: The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we explored the effect of vorapaxar on myocardial infarction (MI). METHODS AND RESULTS: A blinded, independent central endpoint adjudication committee prospectively defined and classified MI according to the universal MI definition, including peak cardiac marker value (creatine kinase-MB [CK-MB] and/or troponin)...
June 2013: European Heart Journal
https://www.readbyqxmd.com/read/23434768/a-novel-approach-to-systematically-implement-the-universal-definition-of-myocardial-infarction-insights-from-the-champion-platform-trial
#19
COMPARATIVE STUDY
Sergio Leonardi, Adriano A M Truffa, Megan L Neely, Pierluigi Tricoci, Harvey D White, C Michael Gibson, Matthew Wilson, Gregg W Stone, Robert A Harrington, Deepak L Bhatt, Kenneth W Mahaffey
OBJECTIVE: To reassess the efficacy of cangrelor efficacy using the universal definition of myocardial infarction (MI). DESIGN: We adopted a novel approach to systematically implement the universal definition of MI. Two physicians blinded to treatment allocation reviewed plots of CK-MB and troponin values in relation to time of randomisation and percutaneous coronary intervention (PCI) to identify patients with stable or falling biomarkers pre-PCI (ie, primary cohort), and those with post-PCI CK-MB elevations...
September 2013: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/23182401/association-of-the-genetic-variants-of-endothelial-nitric-oxide-synthase-gene-with-angiographically-defined-coronary-artery-disease-and-myocardial-infarction-in-south-indian-patients-with-type-2-diabetes-mellitus
#20
Parimala Narne, Kamakshi Chaithri Ponnaluri, Shailender Singh, Mohammed Siraj, Mohammed Ishaq
INTRODUCTION: The polymorphic variants of endothelial nitric oxide synthase (eNOS) gene have been implicated in endothelial dysfunction and are highly relevant to macroangiopathies. We investigated the relationship between eNOS gene T-786C, G894T, intron 4a/b polymorphisms and coronary artery disease (CAD) in South Indian type 2 diabetic (T2DM) individuals. METHODS: We screened 283 T2DM patients, inclusive of 160 with angiographically defined CAD, 73 with myocardial infarction (MI), 89 without MI and 121 T2DM individuals with no evidence of CAD for eNOS gene polymorphisms...
May 2013: Journal of Diabetes and its Complications
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