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GMALL 07/03

Tobias Herold, Stephanie Schneider, Klaus H Metzeler, Martin Neumann, Luise Hartmann, Kathryn G Roberts, Nikola P Konstandin, Philipp A Greif, Kathrin Bräundl, Bianka Ksienzyk, Natalia Huk, Irene Schneider, Evelyn Zellmeier, Vindi Jurinovic, Ulrich Mansmann, Wolfgang Hiddemann, Charles G Mullighan, Stefan K Bohlander, Karsten Spiekermann, Dieter Hoelzer, Monika Brüggemann, Claudia D Baldus, Martin Dreyling, Nicola Gökbuget
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterization of Ph-like ALL in adults. Twenty-six (13%) of 207 adult patients (median age: 42 years) with B-cell precursor ALL (BCP-ALL) were classified as having Ph-like ALL using gene expression profiling. The frequency of Ph-like ALL was 27% among 95 BCP-ALL patients negative for BCR-ABL1 and KMT2A-rearrangements...
January 2017: Haematologica
Andrea Kühnl, Nicola Gökbuget, Martin Kaiser, Cornelia Schlee, Andrea Stroux, Thomas Burmeister, Liliana H Mochmann, Dieter Hoelzer, Wolf-Karsten Hofmann, Eckhard Thiel, Claudia D Baldus
Aberrant activation of the Wnt pathway plays a pathogenetic role in various tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). LEF1, a key mediator of Wnt signaling, has been linked to leukemic transformation, and recurrent mutations of LEF1 have been identified in pediatric T-ALL. Here we evaluated the prognostic significance of LEF1 expression in B-precursor ALL patients. LEF1 expression was determined by quantitative real-time RT-PCR in 282 adult B-precursor ALL patients treated on 06/99 and 07/03 GMALL trials...
December 8, 2011: Blood
Sandra Heesch, Nicola Goekbuget, Andrea Stroux, Jutta Ortiz Tanchez, Cornelia Schlee, Thomas Burmeister, Stefan Schwartz, Olga Blau, Ulrich Keilholz, Antonia Busse, Dieter Hoelzer, Eckhard Thiel, Wolf-Karsten Hofmann, Claudia D Baldus
BACKGROUND: The role of the Wilms tumor 1 gene (WT1) in acute leukemias has been underscored by mutations found in acute myeloid leukemia identifying patients with inferior survival. Furthermore, aberrant expression of WT1 in acute myeloid leukemia was associated with an increased risk of relapse. No larger studies have performed a combined approach including WT1 mutation and expression analyses in acute T-lymphoblastic leukemia. DESIGN AND METHODS: We analyzed the WT1 mutations and the expression status in a total of 252 consecutive adult patients with newly diagnosed T-lymphoblastic leukemia, who were registered on the GMALL 06/99 and 07/03 protocols and had sufficient material available...
June 2010: Haematologica
Andrea Kühnl, Nicola Gökbuget, Andrea Stroux, Thomas Burmeister, Martin Neumann, Sandra Heesch, Torsten Haferlach, Dieter Hoelzer, Wolf-Karsten Hofmann, Eckhard Thiel, Claudia D Baldus
Overexpression of BAALC is an adverse prognostic factor in adults with cytogenetically normal acute myeloid leukemia and T-cell acute lymphoblastic leukemia (ALL). Here, we analyzed the prognostic significance of BAALC in B-precursor ALL. BAALC MRNA expression was determined in 368 primary adult B-precursor ALL patients enrolled on the 06/99 and 07/03 GMALL trials. Patients were grouped into tertiles according to BAALC expression (T1-T3). Higher BAALC expression (T3 vs T2 vs T1) was associated with higher age (P < ...
May 6, 2010: Blood
Lars Fischer, Nicola Gökbuget, Stefan Schwartz, Thomas Burmeister, Harald Rieder, Monika Brüggemann, Dieter Hoelzer, Eckhard Thiel
BACKGROUND: Expression of CD56 has been associated with poor prognosis in acute myeloid leukemia and aggressive lymphoma. DESIGN AND METHODS: We analyzed the impact of CD56 expression in a cohort of 452 newly diagnosed adult T-cell acute lymphoblastic leukemia (T-ALL) patients; clinical data were available for 306 patients. Treatment was according to the GMALL study protocols 06/99 and 07/03 stipulating stratification into standard (thymic T-ALL) and high risk (pre- and mature T-ALL) groups...
February 2009: Haematologica
Florian Seyfarth, Mirjana Ziemer, Herbert G Sayer, Anke Burmester, Marcel Erhard, Martin Welker, Sibylle Schliemann, Eberhard Straube, Uta-Christina Hipler
Although mycoses are among the most common diseases worldwide, infections with Fusarium spp. occur only rarely. Mostly patients suffering from underlying immune deficiency are infected with this mould, resulting in a considerably decreasing prognosis. In immunocompromised patients, cutaneous manifestations are more often associated with Fusarium sp. than with Candida sp. or Aspergillus sp. We describe one patient with acute lymphoblastic leukaemia, who was first treated with chemotherapy after GMALL protocol 07/03...
November 2008: Experimental Dermatology
Thorsten Raff, Nicola Gökbuget, Silke Lüschen, Regina Reutzel, Matthias Ritgen, Sebastian Irmer, Sebastian Böttcher, Heinz-August Horst, Michael Kneba, Dieter Hoelzer, Monika Brüggemann
Although levels of minimal residual disease (MRD) decrease below the detection limit in most adult patients with standard-risk acute lymphoblastic leukemia (ALL) after consolidation treatment, about 30% of these patients will ultimately relapse. To evaluate the power of MRD monitoring as an indicator of impending relapse, we prospectively analyzed postconsolidation samples of 105 patients enrolled in the German Multicenter ALL (GMALL) trial by real-time quantitative polymerase chain reaction (PCR) of clonal immune gene rearrangements...
February 1, 2007: Blood
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