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https://www.readbyqxmd.com/read/28350677/insight-into-the-pathophysiologic-mechanisms-behind-cognitive-dysfunction-in-trigonocephaly
#1
Joris J B van der Vlugt, Jacques J M N van der Meulen, Robert R J Coebergh van den Braak, Christl Vermeij-Keers, Edwin G C Horstman, Steven E R Hovius, Frank C Verhulst, André I Wierdsma, Maarten H Lequin, Jolanda M E Okkerse
BACKGROUND: The relationship between trigonocephaly and cognitive problems might be explained by: secondary mechanical factors related to growth restriction of the skull, and primary structural defects caused by a shared mechanism related to brain developmental disorder(s) and skull malformation. However, because the exact pathophysiology remains unknown, we examined the pathophysiologic mechanisms behind cognitive dysfunction in patients with trigonocephaly, with an aim of providing a model for cognitive dysfunction based on routinely available variables...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350671/enhanced-calvarial-bone-healing-in-cd11c-tlr4-and-myd88-mice
#2
Dan Wang, Gwen M Taylor, James R Gilbert, Joseph E Losee, Chhinder P Sodhi, David J Hackam, Timothy R Billiar, Gregory M Cooper
BACKGROUND: Inflammation is integral to the injury response. The inflammatory response is essential to the host defense against infection and also to tissue regeneration and repair. Toll-like receptors (TLRs) are critical activators of the innate immune response and present attractive therapeutic targets for inflammation-modulated tissue regeneration. The authors' previous study showed that depletion of TLR4 resulted in accelerated skull bone healing concurrent with increased expression of osteoclastogenic genes...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28346963/point-of-care-testing-in-neurosurgery
#3
Christopher Beynon, Lars Wessels, Andreas W Unterberg
Coagulation disorders can have a major impact on the outcome of neurosurgical patients. The central nervous system is located within the closed space of the skull, and therefore, intracranial hemorrhage can lead to intracranial hypertension. Acute brain injury has been associated with alterations of various hemostatic parameters. Point-of-care (POC) techniques such as rotational thromboelastometry are able to identify markers of coagulopathy which are not reflected by standard assessment of hemostasis (e.g...
March 27, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28346666/disseminated-peripheral-neuroblastoma-in-a-rhodesian-ridgeback-dog
#4
R W Cook, L A Abraham, C I McCowan
CASE REPORT: A 4-year-old neutered male Rhodesian Ridgeback dog with right-sided Horner's syndrome, bilateral laryngeal paralysis, neck pain and bilateral hindlimb ataxia was euthanased following deterioration of its neurological status. Necropsy examination revealed an off-white retropharyngeal neoplastic mass (100 × 30 × 30 mm) attached to the base of the skull on the right side and macroscopic nodular metastases in the spleen and three vertebral bodies (C6, C7 and T6), including a nodule attached to the dura at C7...
April 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28346646/metastatic-chordoma-of-the-tongue-case-report
#5
Sultan Bişkin, Rabiye Uslu Erdemir, Sultan Şevik Eliçora, Sevim Aydınlı, Şükrü Oğuz Özdamar
Chordomas are rare bone tumors that arise from notochord remnants. They most commonly occur in the sacrum, but they also can be seen in the skull base, cervical spine, and thoracolumbar vertebrae. Chordomas account for 1 to 4% of all primary skeletal tumors. They are usually indolent, locally growing tumors. Distant metastasis has been reported in 3 to 48% of cases. When metastasis occurs, it is usually observed in the lung, bone, and liver. To the best of our knowledge, no case of a chordoma metastasis to the tongue has been previously reported in the literature...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28346016/dsl-prescriptive-targets-for-bone-conduction-devices-adaptation-and-comparison-to-clinical-fittings
#6
William E Hodgetts, Susan D Scollie
OBJECTIVE: To develop an algorithm that prescribes targets for bone conduction frequency response shape, compression, and output limiting, along with a clinical method that ensures accurate transforms between assessment and verification stages of the clinical workflow. DESIGN: Technical report of target generation and validation. STUDY SAMPLE: We recruited 39 adult users of unilateral percutaneous bone conduction hearing aids with a range of unilateral, bilateral, mixed and conductive hearing losses across the sample...
March 27, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28345519/anatomical-landmarks-for-maxillary-nerve-block-in-the-pterygopalatine-fossa-a-radiological-study
#7
S Carrier, B Castagneyrol, L Beylacq, K Nouette-Gaulain, M Montaudon, M Laurentjoye
INTRODUCTION: The aim of this study was to describe the anatomical landmarks for maxillary nerve block in the pterygopalatine fossa. The risk of injury to the skull base and maxillary artery was assessed. METHODS: This retrospective study was based on the analysis of 61 consecutive computed tomography angiographies obtained from patients suffering from different pathologies. Anatomical relationships between optic canal (OC), foramen rotundum (FR), inferior orbital fissure (IOF) and puncture point (PP) were assessed...
February 22, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28344549/functional-brain-activation-in-response-to-a-clinical-vestibular-test-correlates-with-balance
#8
Fatemeh Noohi, Catherine Kinnaird, Yiri DeDios, Igor S Kofman, Scott Wood, Jacob Bloomberg, Ajitkumar Mulavara, Rachael Seidler
The current study characterizes brain fMRI activation in response to two modes of vestibular stimulation: Skull tap and auditory tone burst. The auditory tone burst has been used in previous studies to elicit either a vestibulo-spinal reflex [saccular-mediated colic Vestibular Evoked Myogenic Potentials (cVEMP)], or an ocular muscle response [utricle-mediated ocular VEMP (oVEMP)]. Research suggests that the skull tap elicits both saccular and utricle-mediated VEMPs, while being faster and less irritating for subjects than the high decibel tones required to elicit VEMPs...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28344182/repair-of-frontoethmoidal-encephalocele-in-the-philippines-an-account-of-30-cases-between-2008-2013
#9
Amanda-Lynn Marshall, Pradeep Setty, Mark Hnatiuk, Daniel R Pieper
BACKGROUND: Frontoethmoidal encephalocele is a congenital abnormality of the anterior skull base involving herniation of cranial contents through a midline skull defect. Patency of the foramen cecum, along with other multifactorial variables, contribute to the development of frontoethmoidal encephaloceles. Due to limited resources, financial constraints, and lack of surgical expertise, repair of frontoethmoidal encephaloceles are limited in developing countries. METHODS: Between 2008-2013 an interdisciplinary team composed of neurosurgeons, craniofacial surgeons, otolaryngologists, plastic surgeons and nursing personnel, conducted surgical mission trips to Davao City in Mindanao, Philippines...
March 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28343887/corrigendum-to-magnetoencephalography-signals-are-influenced-by-skull-defects-clin-neurophysiol-125-2014-1653-1662
#10
S Lau, L Flemming, J Haueisen
No abstract text is available yet for this article.
March 23, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28343651/reconstruction-of-large-cranial-defects-with-poly-methyl-methacrylate-pmma-using-a-rapid-prototyping-model-and-a-new-technique-for-intraoperative-implant-modeling
#11
Claudia Unterhofer, Christoph Wipplinger, Michael Verius, Wolfgang Recheis, Claudius Thomé, Martin Ortler
BACKGROUND: Reconstruction of large cranial defects after craniectomy can be accomplished by free-hand poly-methyl-methacrylate (PMMA) or industrially manufactured implants. The free-hand technique often does not achieve satisfactory cosmetic results but is inexpensive. In an attempt to combine the accuracy of specifically manufactured implants with low cost of PMMA. METHODS: Forty-six consecutive patients with large skull defects after trauma or infection were retrospectively analyzed...
March 10, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28342117/otto-mennicke-1876-and-the-first-description-of-skull-base-anomalies-causing-cerebellar-tonsillar-ectopia-one-of-the-first-mentions-of-the-chiari-i-malformation
#12
Fabian N Fries, Philipp Hendrix, Titus J Brinker, Marios Loukas, R Shane Tubbs
INTRODUCTION: Although Hans Chiari made significant and meaningful contributions to our understanding and classification of hindbrain herniations, others have also contributed to this knowledge. One figure who has been lost to history is Otto Mennicke. Herein, we discuss his role in our understanding of tonsillar ectopia and his life and connection to Hans Chiari. CONCLUSIONS: Our knowledge of what is now known as the Chiari malformations has been shaped by several clinicians including Otto Mennicke...
March 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28338894/establishment-of-radiation-doses-for-pediatric-x-ray-examinations-in-a-large-pediatric-hospital-in-turkey
#13
T Olgar, T Sahmaran
Pediatric patients are more sensitive to ionizing radiation when compared with adults. The aim of this study was to evaluate the radiation doses for some common pediatric x-ray examinations performed with various digital radiography systems. Quality control tests of the digital radiography systems were carried out according to international published protocols before the pediatric dose measurements. Radiation dose measurement was performed by using the x-ray tube outputs and thermoluminescent dosimeter dose measurement methods...
February 25, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28338846/patient-exposure-during-plain-radiography-and-mammography-in-japan-in-1974-2014
#14
Yuta Matsunaga, Ai Kawaguchi, Kenichi Kobayashi, Masanao Kobayashi, Yasuki Asada, Kazuyuki Minami, Shoichi Suzuki, Koichi Chida
We investigated changes in the entrance skin dose (ESD) and the mean glandular dose (MGD) during plain radiography or mammography in Japan from 1974 to 2014. Surveys regarding the conditions used for plain radiography and mammography were performed throughout Japan in 1974, 1979, 1989, 1993, 1997, 2001, 2003, 2007, 2011 and 2014. The anatomical regions considered were categorised as follows: skull anteroposterior (AP), lumbar AP, lumbar lateral (LAT), pelvis (AP), ankle, chest posteroanterior (PA), Guthmann (lateral pelviography for pregnant women), infant hip joint and mammography...
March 1, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28338720/from-teeth-to-baleen-and-raptorial-to-bulk-filter-feeding-in-mysticete-cetaceans-the-role-of-paleontological-genetic-and-geochemical-data-in-feeding-evolution-and-ecology
#15
Annalisa Berta, Agnese Lanzetti, Eric G Ekdale, Thomas A Deméré
The origin of baleen and filter feeding in mysticete cetaceans occurred sometime between approximately 34 and 24 million years ago and represents a major macroevolutionary shift in cetacean morphology (teeth to baleen) and ecology (raptorial to filter feeding). We explore this dramatic change in feeding strategy by employing a diversity of tools and approaches: morphology, molecules, development, and stable isotopes from the geological record. Adaptations for raptorial feeding in extinct toothed mysticetes provide the phylogenetic context for evaluating morphological apomorphies preserved in the skeletons of stem and crown edentulous mysticetes...
December 16, 2016: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28338593/clinical-correlates-to-assist-with-cte-diagnosis-insights-from-a-novel-rodent-repeat-concussion-model
#16
Gretchen M Thomsen, Ara Ko, Megan Y Harada, Annie Ma, Livia Wyss, Patricia Haro, Jean-Philippe Vit, Pablo Avalos, Navpreet Dhillon, Noell Cho, Oksana Shelest, Eric J Ley
INTRODUCTION: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. CTE symptoms include changes in mood, behavior, cognition and motor function, however CTE is only currently diagnosed post-mortem. Using a rat model of recurrent traumatic brain injury (TBI) we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. METHODS: Bilateral, closed skull, mild TBI was administered once per week to 35 WT rats, 8 rats received 2 injuries ('2xTBI'), 27 rats received 5 injuries ('5xTBI') and 13 rats were sham controls...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28338248/surgical-strategy-for-apert-syndrome-retrospective-study-of-developmental-quotient-and-three-dimensional-computerized-tomography
#17
Shoichi Tomita, Takeshi Miyawaki, Yuichirou Nonaka, Shinsuke Sakai, Reiji Nishimura
There are many surgical techniques for craniosynostosis. However, the indications for and timing of surgery still remain unclarified. Most of the skull growth in craniosynostosis is completed in the first year, and the bone is strong enough to undergo distraction osteogenesis. However, previous reports showed that patients operated on before 1 year of age had better IQ than those operated later in life. This report aims to consider the best timing for cranial expansion and surgical strategy for Apert syndrome...
March 24, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28337886/osteogenesis-promoting-activity-of-composites-sba-15-mesoporous-particles-carrying-oxytocin-in-vitro-and-in-vivo
#18
L Cheng, X He, Y Che, H Che, M Qian
This study analyzes the performance of SBA-15 mesoporous particles carrying oxytocin (OT) in promoting osteogenesis in vitro and in vivo. The SBA-15 particles synthesized in the previous studies (about 30 μm in diameter and containing 10 nm deep pores) were loaded with the drug oxytocin and cultured with human osteosarcoma MG-63 cell line in vitro. The influence of particles on cell proliferation was studied. The level of the osteogenic marker (alkaline phosphatase and type I collagen) was measured. For in vivo studies, the connectivity defects of rabbit skull were prepared, and SBA-15 suspensions were regularly injected at the defect sites...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337800/mycoplasma-infection-of-the-middle-ear-in-three-cats
#19
Amanda L Ackermann, Jennifer Ann Lenz, Elizabeth R May, Linda A Frank
BACKGROUND: Mycoplasma spp. are commensal organisms found in association with the mucus membranes of all mammalian species and are implicated in bacterial infections of many different locations. Mycoplasma spp. as a primary pathogen associated with otitis media in cats has not been reported. OBJECTIVES: To describe three cats with Mycoplasma infection of the middle ear associated with various underlying disease processes. ANIMALS: Three client-owned cats...
March 23, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28337382/a-new-t-staging-system-for-nasopharyngeal-carcinoma-based-on-intensity-modulated-radiation-therapy-results-from-a-prospective-multicentric-clinical-study
#20
Min Kang, Pingting Zhou, Tingting Wei, Tingting Zhao, Jianxiong Long, Guisheng Li, Haolin Yan, Guosheng Feng, Meilian Liu, Jinxian Zhu, Rensheng Wang
PURPOSE: This prospective multicentric study aimed to establish a new clinical T staging standard for nasopharyngeal carcinoma (NPC) based on intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Between January 2006 and December 2009, four hundred and ninety-two NPC patients undergoing IMRT were staged according to the seventh edition of the UICC/AJCC staging system. The Kaplan-Meier method was used to calculate survival rates, and the log-rank test was used to compare survival differences...
2017: American Journal of Cancer Research
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