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https://www.readbyqxmd.com/read/28527218/the-mechanisms-of-action-of-curcumin-in%C3%A2-alzheimer-s-disease
#1
Mengxi Tang, Changiz Taghibiglou
Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As the prevalence of AD rises in the 21st century, there is an urgent need for the development of effective pharmacotherapies. Currently, drug treatments target the symptoms of the disease and do not modify or halt the disease progress. Thus, natural compounds have been investigated for their ability to treat AD. This review examines the efficacy of curcumin, a polyphenol derived from turmeric herb, to treat AD. We summarize the in vivo and in vitro research describing the mechanisms of action in which curcumin modifies AD pathology: curcumin inhibits the formation and promotes the disaggregation of amyloid-β plaques, attenuates the hyperphosphorylation of tau and enhances its clearance, binds copper, lowers cholesterol, modifies microglial activity, inhibits acetylcholinesterase, mediates the insulin signaling pathway, and is an antioxidant...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28526570/role-of-medicinal-plants-on-growth-performance-and-immune-status-in-fish
#2
REVIEW
Elham Awad, Amani Awaad
Disease outbreaks increase proportionally with increases in intensive aquaculture. Natural products including medicinal plants have been known from thousands of years for treating some human diseases. It is well known that many active compounds are responsible for potential bio-activities. For that reason, there has been considerable interest in the use of medicinal plants in aquaculture with a view to providing safe and eco-friendly compounds for replacing antibiotics and chemical compounds as well as to enhance immune status and control fish diseases...
May 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28526079/patient-needs-and-preferences-for-herb-drug-disease-interaction-alerts-a-structured-interview-study
#3
Carrie M Christensen, Rebecca S Morris, Seraphine Chepkemoi Kapsandoy, Melissa Archer, Jinqiu Kuang, Laura Shane-McWhorter, Bruce E Bray, Qing Zeng-Treitler
BACKGROUND: While complementary and alternative medicine (CAM) is commonly used in the United States and elsewhere, and hazardous interactions with prescription drugs can occur, patients do not regularly communicate with physicians about their CAM use. The objective of this study was to discover patient information needs and preferences for herb-drug-disease interaction alerts. METHODS: We recruited 50 people from several locations within the University of Utah Hospital to participate in this structured interview study...
May 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28523296/a-systematic-review-of-the-possible-carcinogenic-role-of-the-aristolochic-acid
#4
Tivadar Bara, Simona Gurzu, Haruhiko Sugimura, Tivadar Bara, Marius Alexandru Beleaua, Ioan Jung
Aristolochic acid (AA) is a bioactive component of Chinese herbs, dietary supplements, slimming pills and contaminated flour, which is known to induce chronic tubulointerstitial disease. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma (UTUC) and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis. Twenty representative papers were selected for this review...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521703/recent-advances-in-antiepileptic-herbal-medicine
#5
Stephen M Manchishi
Epilepsy is one of the most common neurological disorders worldwide, with about 80 percent of cases thought to be in developing nations where it is mostly linked to superstition. Most cases of epilepsy are idiopathic, though brain injury, brain tumor, severe systemic infection and genetic mutations have been implicated in some cases. Anti-epileptic drugs (AEDs) currently in existence are not sufficient to contain the disorder. This is not only because of their limited availability and cost, but also their adverse side effects...
May 18, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28521274/detection-of-regulated-herbs-and-plants-in-plant-food-supplements-and-traditional-medicines-using-infrared-spectroscopy
#6
E Deconinck, C A Sokeng Djiogo, J L Bothy, P Courselle
The identification of a specific toxic or regulated plant in herbal preparations or plant food supplements is a real challenge, since they are often powdered, mixed with other herbal or synthetic powders and compressed into tablets or capsules. The classical identification approaches based on micro- and macroscopy are therefore not possible anymore. In this paper infrared spectroscopy, combined with attenuated total reflectance was evaluated for the screening of plant based preparations for nine specific plants (five regulated and four common plants for herbal supplements)...
May 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28520731/genetically-engineered-probiotic-for-the-treatment-of-phenylketonuria-pku-assessment-of-a-novel-treatment-in-vitro-and-in-the-pahenu2-mouse-model-of-pku
#7
Katherine E Durrer, Michael S Allen, Ione Hunt von Herbing
Phenylketonuria (PKU) is a genetic disease characterized by the inability to convert dietary phenylalanine to tyrosine by phenylalanine hydroxylase. Given the importance of gut microbes in digestion, a genetically engineered microbe could potentially degrade some ingested phenylalanine from the diet prior to absorption. To test this, a phenylalanine lyase gene from Anabaena variabilis (AvPAL) was codon-optimized and cloned into a shuttle vector for expression in Lactobacillus reuteri 100-23C (pHENOMMenal). Functional expression of AvPAL was determined in vitro, and subsequently tested in vivo in homozygous PAHenu2 (PKU model) mice...
2017: PloS One
https://www.readbyqxmd.com/read/28519965/micellar-electrokinetic-chromatography-fingerprinting-combined-with-chemometrics-as-an-efficient-strategy-for-evaluating-the-quality-consistency-and-predicting-the-antioxidant-activity-of-lianqiao-baidu-pills
#8
Shuai Chen, Guoxiang Sun, Lanping Yang, Jing Zhang
An approach combining micellar electrokinetic chromatography (MEKC) fingerprinting with chemometrics was developed to evaluate the quality consistency of Lianqiao Baidu pills (LQDBPs), which are a traditional Chinese patent medicine composed of nineteen herbs used mainly to treat skin ulcers, the common cold, rheumatism, herpes, and constipation. The triangle optimization method was employed to choose a satisfactory background electrolyte, with the information index, I, as an objective function for assessing the capillary electrophoresis conditions...
May 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28517911/is-there-a-potential-of-misuse-for-magnolia-officinalis-compounds-metabolites
#9
Fabrizio Schifano, Valentina Guarino, Duccio G Papanti, Jacopo Baccarin, Laura Orsolini, John M Corkery
OBJECTIVE: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. METHODS: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. RESULTS: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28514413/university-spin-offs
#10
Herb Brody
No abstract text is available yet for this article.
May 17, 2017: Nature
https://www.readbyqxmd.com/read/28514052/shift-in-community-structure-in-an-early-successional-mediterranean-shrubland-driven-by-long-term-experimental-warming-and-drought-and-natural-extreme-droughts
#11
Daijun Liu, Marc Estiarte, Romà Ogaya, Xiaohong Yang, Josep Peñuelas
Global warming and recurring drought are expected to accelerate water limitation for plant communities in semiarid Mediterranean ecosystems and produce directional shifts in structure and composition that are not easily detected, and supporting evidence is scarce. We conducted a long-term (17 years) nocturnal-warming (+0.6 °C) and drought (-40% rainfall) experiment in an early-successional Mediterranean shrubland to study the changes in community structure and composition, contrasting functional groups and dominant species, and the superimposed effects of natural extreme drought...
May 17, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28512988/phytochemistry-and-pharmacology-of-phyllanthus-niruri-l-a-review
#12
REVIEW
Navneet Kaur, Baljinder Kaur, Geetika Sirhindi
Phyllanthus niruri, a typical member of family Euphorbiaceae, is a small annual herb found throughout the tropical and subtropical regions of both hemispheres. The genus Phyllanthus has been used in traditional medicine for its wide range of pharmacological activities like antimicrobial, antioxidant, anticancer, antiinflammatory, antiplasmodial, antiviral, diuretic and hepatoprotective. This review summarizes the information about morphological, biochemical, ethanobotanical, pharmacological, biological and toxicological activities with special emphasis on mechanism of anticancer activity of P...
May 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28512597/documentation-of-ethnomedicinal-information-and-antimicrobial-validation-of-thespesia-populnea-used-by-yanadi-tribe-of-ganugapenta-village-chittoor-district-andhra-pradesh-india
#13
Nataru Savithramma, Pulicherla Yugandhar, Pallipati Suvarnalatha Devi, Sade Ankanna, Damai Suhrulatha, Koya Siva Prasad, Ramakrishanan Ranjani, Nagoji Nagaraju, Kummara Madhava Chetty
AIM: This study aimed to document the traditional knowledge of medicinal plants and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Chittoor district, Andhra Pradesh, India. MATERIALS AND METHODS: The study was mainly focused on documentation of medicinal plants used by Yanadi tribe to treat different diseases with a standard questionnaire. These plants were cross-checked in Dr. Dukes Database and available literature to know the significance of this tribe on medicinal knowledge...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512499/neuroprotective-effect-of-fagopyrum-dibotrys-extract-against-alzheimer-s-disease
#14
Chen Liang, Jian-Ping Yuan, Tao Ding, Lv Yan, Lu Ling, Xin-Fu Zhou, Yue-Qin Zeng
Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. Fagopyrum dibotrys is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of Fagopyrum dibotrys extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of Aβ peptide were evaluated in vitro...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28512368/-analysis-of-the-phenomenon-of-over-the-counter-drug-abuse-and-not-controlled-herbs-trade-by-polish-adolescents-part-i
#15
REVIEW
Daria Suchecka, Jolanta Kucharska-Mazur, Katarzyna Groszewska, Monika Mak, Jerzy Samochowiec, Agnieszka Samochowiec
The phenomenon of stupefying by the use of available over-the-counter drugs (OTC) among adolescents is an essential problem in both Poland and throughout the world. Popular analgesics, cold medicine and antihistamines contain psychedelic substances, such as dextromethorphan (DXM), pseudoephedrine/ephedrine, codeine (methylmorphine), dimenhydrinate, paracetamol (acetaminophren) and others. Cases of fatal addiction to dextromethorphan, one of the active substances contained in medicines, e.g., the common cold, have been reported...
May 16, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28511530/herbs-in-oral-mucositis
#16
REVIEW
Maryam Baharvand, Soudeh Jafari, Hamed Mortazavi
Oral mucositis is an inflammatory mucosal destruction as a result of chemotherapy and/or radiation therapy, which in severe cases can impair patients' quality of life. Moreover, mucosal infection and/or systemic involvement due to compromised immunity leads to delay or discontinuation of the treatment. Many strategies and agents have been suggested for the management of this condition. Because of their lower side effects compared to chemical drugs, general interest in evaluating therapeutic effects of herbs has been increased intensively...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511517/holistic-healing-through-herbs-effectiveness-of-aloe-vera-on-post-extraction-socket-healing
#17
Vijaya Lakshmi Nimma, Harsha Vardhan Talla, Jaya Krishna Bairi, Madhulatha Gopaldas, Haritha Bathula, Sandeep Vangdoth
INTRODUCTION: Advances in the field of alternative medicine has encouraged the use of various natural products for multiple uses in the field of dentistry for treatment of various oral diseases. A natural herbal product is Aloe vera, which has number of benefits with no reported side effects and gaining considerable importance in clinical research. AIM: The aim of this cross-sectional randomized interventional study was to evaluate the effectiveness of Aloe vera in the healing of post extraction sockets...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511362/towards-complete-and-harmonized-assessment-of-soil-carbon-stocks-and-balance-in-forests-the-ability-of-the-yasso07-model-across-a-wide-gradient-of-climatic-and-forest-conditions-in-europe
#18
Laura Hernández, Robert Jandl, Viorel N B Blujdea, Aleksi Lehtonen, Kaie Kriiska, Iciar Alberdi, Veiko Adermann, Isabel Cañellas, Gheorghe Marin, Daniel Moreno-Fernández, Ivika Ostonen, Mats Varik, Markus Didion
Accurate carbon-balance accounting in forest soils is necessary for the development of climate change policy. However, changes in soil organic carbon (SOC) occur slowly and these changes may not be captured through repeated soil inventories. Simulation models may be used as alternatives to SOC measurement. The Yasso07 model presents a suitable alternative because most of the data required for the application are readily available in countries with common forest surveys. In this study, we test the suitability of Yasso07 for simulating SOC stocks and stock changes in a variety of European forests affected by different climatic, land use and forest management conditions and we address country-specific cases with differing resources and data availability...
May 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28510702/linking-vegetation-structure-and-spider-diversity-in-riparian-and-adjacent-habitats-in-two-rivers-of-central-argentina-an-analysis-at-two-conceptual-levels
#19
Mariana Griotti, Christian Muñoz-Escobar, Nelson E Ferretti
The link between vegetation structure and spider diversity has been well explored in the literature. However, few studies have compared spider diversity and its response to vegetation at two conceptual levels: assemblage (species diversity) and ensemble (guild diversity). Because of this, we studied spider diversity in riparian and adjacent habitats of a river system from the Chacoan subregion in central Argentina and evaluated their linkage with vegetation structure at these two levels. To assess vegetation structure, we measured plant species richness and vegetation cover in the herb and shrub - tree layers...
May 15, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28509626/custom-compounded-bioidentical-hormone-therapy-why-so-popular-despite-potential-harm-the-case-against-routine-use
#20
M L'Hermite
Wide rejection of conventional hormone therapy (HT) after the initial publication of the Women's Health Initiative (WHI) led to unjustified use of custom-compounded bioidentical hormones. In the USA, it became an unregulated drug manufacturer industry in disguise, without proper control and making false claims and misleading advertisements. Manufacturing quality is not ensured. Unspecific harm from compounding has occurred on a large scale, such as deaths from infected products and end-stage renal failure plus carcinoma due to confusion between different Chinese herbs...
June 2017: Climacteric: the Journal of the International Menopause Society
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