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Flakka

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https://www.readbyqxmd.com/read/27418996/flakka-induced-prolonged-psychosis
#1
Craig Crespi
In South Florida, there has been a highly addictive new synthetic drug flooding the streets for people looking for a cheap high. Alpha-PVP, better known as Flakka, is an illegal substance that sells on the streets for as little as $5 a hit and delivers an instant high that can last from hours to days with lingering effects for weeks after it has been ingested. Although people use Flakka for its potential euphoric high, symptoms are known to easily escalate into frightening delusions, paranoid psychosis, extreme agitation, and a multitude of other altered mental states...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/27142261/neurobiology-of-3-4-methylenedioxypyrovalerone-mdpv-and-%C3%AE-pyrrolidinovalerophenone-%C3%AE-pvp
#2
Richard A Glennon, Richard Young
Synthetic cathinones are analogs of cathinone or β-ketoamphetamine - the major psychostimulant component of the shrub Catha edulis or khat. Cathinone analogs - though not termed as such - have been known for>100years, but confusing chemical nomenclature often made the topic difficult to appreciate. In addition, many of the early analogs were prepared as synthetic precursors for the development of various other agents, and relatively few were pharmacologically evaluated. Cathinone is a close structural relative of amphetamine...
April 29, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/26217965/structural-modification-of-the-designer-stimulant-%C3%AE-pyrrolidinovalerophenone-%C3%AE-pvp-influences-potency-at-dopamine-transporters
#3
R Kolanos, F Sakloth, A D Jain, J S Partilla, M H Baumann, R A Glennon
α-Pyrrolidinovalerophenone (α-PVP, 7) is an illegal synthetic stimulant that is being sold on the clandestine market as "flakka" and "gravel". The potent pharmacological effects of α-PVP are presumably mediated by inhibition of dopamine uptake at the dopamine transporter (DAT). However, little is known about how structural modification of α-PVP influences activity at DAT. Eleven analogs of α-PVP were synthesized and examined for their ability to inhibit uptake of [(3)H]dopamine and [(3)H]serotonin in rat brain synaptosomes...
October 21, 2015: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/25925780/in-vivo-potency-and-efficacy-of-the-novel-cathinone-%C3%AE-pyrrolidinopentiophenone-and-3-4-methylenedioxypyrovalerone-self-administration-and-locomotor-stimulation-in-male-rats
#4
Shawn M Aarde, Kevin M Creehan, Sophia A Vandewater, Tobin J Dickerson, Michael A Taffe
RATIONALE: Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"). OBJECTIVES: This study aimed to directly compare the efficacy and potency of alpha-PVP with that of MDPV. METHODS: Groups of male Wistar rats were trained in the intravenous self-administration (IVSA) alpha-PVP or MDPV under a fixed-ratio 1 schedule of reinforcement...
August 2015: Psychopharmacology
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