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Melatonin AND Sirt1

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https://www.readbyqxmd.com/read/27889913/long-term-melatonin-treatment-delays-ovarian-aging
#1
Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J Reiter, Norihiro Sugino
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti-aging agent due to its cytoprotective actions as an antioxidant. The present study examined whether long-term melatonin treatment would delay ovarian aging in mice. Female ICR mice (10 weeks old) were given melatonin-containing water (100 μg/ml; melatonin) or water only until 43 weeks of age. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological analysis of the number of follicles...
November 27, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27763686/melatonin-and-the-pathologies-of-weakened-or-dysregulated-circadian-oscillators
#2
Rüdiger Hardeland
Dynamic aspects of melatonin's actions merit increasing future attention. This concerns particularly entirely different effects in senescent, weakened oscillators and in dysregulated oscillators of cancer cells that may be epigenetically blocked. This is especially obvious in the case of sirtuin 1 (SIRT1) which is upregulated by melatonin in aged tissues, but strongly downregulated in several cancer cells. These findings are not at all controversial, but are explained on the basis of divergent changes in weakened and dysregulated oscillators...
October 20, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27696525/melatonin-alleviates-post-infarction-cardiac-remodeling-and-dysfunction-by-inhibiting-mst1
#3
Jianqiang Hu, Lei Zhang, Yang Yang, Yanjie Guo, Yanhong Fan, Mingming Zhang, Wanrong Man, Erhe Gao, Wei Hu, Russel J Reiter, Haichang Wang, Dongdong Sun
Melatonin reportedly protects against several cardiovascular diseases including ischemia/reperfusion (I/R), atherosclerosis and hypertension. The present study investigated the effects and mechanisms of melatonin on cardiomyocyte autophagy, apoptosis and mitochondrial injury in the context of MI. We demonstrated that melatonin significantly alleviated cardiac dysfunction after MI. Four weeks after MI, echocardiography and Masson staining indicated that melatonin notably mitigated adverse left ventricle remodeling...
October 1, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27599451/melatonin-prevents-acute-kidney-injury-in-severely-burned-rats-via-the-activation-of-sirt1
#4
Xiao-Zhi Bai, Ting He, Jian-Xin Gao, Yang Liu, Jia-Qi Liu, Shi-Chao Han, Yan Li, Ji-Hong Shi, Jun-Tao Han, Ke Tao, Song-Tao Xie, Hong-Tao Wang, Da-Hai Hu
Acute kidney injury (AKI) is a common complication after severe burns. Melatonin has been reported to protect against multiple organ injuries by increasing the expression of SIRT1, a silent information regulator that regulates stress responses, inflammation, cellular senescence and apoptosis. This study aimed to investigate the protective effects of melatonin on renal tissues of burned rats and the role of SIRT1 involving the effects. Rat severely burned model was established, with or without the administration of melatonin and SIRT1 inhibitor...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27441728/melatonin-modulates-neonatal-brain-inflammation-through-endoplasmic-reticulum-stress-autophagy-and-mir-34a-silent-information-regulator-1-pathway
#5
Silvia Carloni, Géraldine Favrais, Elie Saliba, Maria Cristina Albertini, Sylvie Chalon, Mariangela Longini, Pierre Gressens, Giuseppe Buonocore, Walter Balduini
Maternal infection/inflammation represents one of the most important factors involved in the etiology of brain injury in newborns. We investigated the modulating effect of prenatal melatonin on the neonatal brain inflammation process resulting from maternal intraperitoneal (i.p.) lipopolysaccharide (LPS) injections. LPS (300 μg/kg) was administered to pregnant rats at gestational days 19 and 20. Melatonin (5 mg/kg) was administered i.p. at the same time as LPS. Melatonin counteracted the LPS sensitization to a second ibotenate-induced excitotoxic insult performed on postnatal day (PND) 4...
October 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27421686/melatonin-stimulates-the-sirt1-nrf2-signaling-pathway-counteracting-lipopolysaccharide-lps-induced-oxidative-stress-to-rescue-postnatal-rat-brain
#6
Shahid Ali Shah, Mehtab Khan, Myeung-Hoon Jo, Min Gi Jo, Faiz Ul Amin, Myeong Ok Kim
AIMS: Lipopolysaccharide (LPS) induces oxidative stress and neuroinflammation both in vivo and in vitro. Here, we provided the first detailed description of the mechanism of melatonin neuroprotection against LPS-induced oxidative stress, acute neuroinflammation, and neurodegeneration in the hippocampal dentate gyrus (DG) region of the postnatal day 7 (PND7) rat brain. METHODS: The neuroprotective effects of melatonin against LPS-induced neurotoxicity were analyzed using multiple research techniques, including Western blotting, immunofluorescence, and enzyme-linked immunosorbent assays (ELISAs) in PND7 rat brain homogenates and BV2 cell lysates in vitro...
July 15, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27274843/resveratrol-compares-with-melatonin-in-improving-in-vitro-porcine-oocyte-maturation-under-heat-stress
#7
Yu Li, Jing Wang, Zhenzhen Zhang, Jinyun Yi, Changjiu He, Feng Wang, Xiuzhi Tian, Minghui Yang, Yukun Song, Pingli He, Guoshi Liu
BACKGROUND: Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants, has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress (HS). The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation (PA)...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/26918354/melatonin-protects-skin-keratinocyte-from-hydrogen-peroxide-mediated-cell-death-via-the-sirt1-pathway
#8
Ju-Hee Lee, Ji-Hong Moon, Uddin Md Nazim, You-Jin Lee, Jae-Won Seol, Seong-Kug Eo, John-Hwa Lee, Sang-Youel Park
Melatonin (N-acetyl-5-methoxytryptamine), which is primarily synthesized in and secreted from the pineal gland, plays a pivotal role in cell proliferation as well as in the regulation of cell metastasis and cell survival in a diverse range of cells. The aim of this study is to investigate protection effect of melatonin on H2O2-induced cell damage and the mechanisms of melatonin in human keratinocytes. Hydrogen peroxide dose-dependently induced cell damages in human keratinocytes and co-treatment of melatonin protected the keratinocytes against H2O2-induced cell damage...
March 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/26867656/melatonin-attenuates-early-brain-injury-via-the-melatonin-receptor-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway-following-subarachnoid-hemorrhage-in-mice
#9
Lei Zhao, Haixiao Liu, Liang Yue, Jingbo Zhang, Xia Li, Bodong Wang, Yan Lin, Yan Qu
Melatonin (Mel) has been reported to alleviate early brain injury (EBI) following subarachnoid hemorrhage (SAH). The activation of silent information regulator 1 (Sirt1), a histone deacetylase, has been suggested to be beneficial in SAH. However, the precise role of Sirt1 in Mel-mediated protection against EBI following SAH has not been elucidated. The present study aims to evaluate the role of melatonin receptor/Sirt1/nuclear factor-kappa B (NF-κB) in this process. The endovascular perforation SAH model was used in male C57BL/6J mice, and melatonin was administrated intraperitoneally (150 mg/kg)...
February 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26824477/hepatic-macrosteatosis-is-partially-converted-to-microsteatosis-by-melatonin-supplementation-in-ob-ob-mice-non-alcoholic-fatty-liver-disease
#10
Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Igor Golic, Marija Aleksic, Aleksandra Korac, Luigi Fabrizio Rodella, Rita Rezzani
BACKGROUND: Obesity is a common risk factor for non-alcoholic fatty liver disease (NAFLD). Currently, there are no specific treatments against NAFLD. Thus, examining any molecule with potential benefits against this condition emerged melatonin as a molecule that influences metabolic dysfunctions. The aim of this study was to determine whether melatonin would function against NAFDL, studying morphological, ultrastuctural and metabolic markers that characterize the liver of ob/ob mice. METHODS: Lean and ob/ob mice were supplemented with melatonin in the drinking water for 8 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/26681113/same-molecule-but-different-expression-aging-and-sepsis-trigger-nlrp3-inflammasome-activation-a-target-of-melatonin
#11
Huayqui Volt, José A García, Carolina Doerrier, María E Díaz-Casado, Ana Guerra-Librero, Luis C López, Germaine Escames, Jesús A Tresguerres, Darío Acuña-Castroviejo
The connection between the innate immune system, clock genes, and mitochondrial bioenergetics was analyzed during aging and sepsis in mouse heart. Our results suggest that the sole NF-κB activation does not explain the inflammatory process underlying aging; the former also triggers the NLRP3 inflammasome that enhances caspase-1-dependent maturation of IL-1β. In this way, aged mice enter into a vicious cycle as IL-1β further activates the NF-κB/NLRP3 inflammasome link. The origin of NF-κB activation was related to the age-dependent Bmal1/Clock/RORα/Rev-Erbα loop disruption, which lowers NAD(+) levels, reducing the SIRT1 deacetylase ability to inactivate NF-κB...
March 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/26679105/evidence-for-possible-role-of-melatonin-in-reducing-oxidative-stress-in-multiple-sclerosis-through-its-effect-on-sirt1-and-antioxidant-enzymes
#12
Solaleh Emamgholipour, Arash Hossein-Nezhad, Mohammad Ali Sahraian, Fatemeh Askarisadr, Mohammad Ansari
AIMS: Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Melatonin has a central role in the modulation of oxidative stress pathways. We aimed to investigate the effect of melatonin on mRNA expression and activity of sirtuin1 (SIRT1) and its target genes, manganese superoxide dismutase (MnSOD), and catalase in peripheral blood mononuclear cells (PBMCs) from MS patients and healthy subjects. KEY METHODS: This study was performed on 12 patients with relapsing-remitting MS (RRMS) and 14 age- and sex-matched healthy subjects...
January 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26663801/nut-midline-carcinoma-morphoproteomic-characterization-with-genomic-and-therapeutic-correlates
#13
Hongxia Sun, Mary F McGuire, Songlin Zhang, Robert E Brown
NUT midline carcinoma is a rare entity arising primarily in the midline of teenagers and young adults. Genomically, it is associated with a translocation involving a nuclear protein in testis (NUT) gene with other genes, most commonly, the BRD4 gene. The resultant is a partial or near total block in differentiation of tumor cells into mature squamous elements. Such tumors are resistant to conventional therapy with a reported mean survival at less than 1 year. In this study, we investigated two cases with genomic confirmation as NUT midline carcinoma by morphoproteomic analysis using immunohistochemical antibodies...
2015: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/26607398/melatonin-facilitates-adipose-derived-mesenchymal-stem-cells-to-repair-the-murine-infarcted-heart-via-the-sirt1-signaling-pathway
#14
Dong Han, Wei Huang, Xiang Li, Lei Gao, Tao Su, Xiujuan Li, Sai Ma, Tong Liu, Congye Li, Jiangwei Chen, Erhe Gao, Feng Cao
Mesenchymal stem cells (MSCs)-based therapy provides a promising therapy for the ischemic heart disease (IHD). However, engrafted MSCs are subjected to acute cell death in the ischemic microenvironment, characterized by excessive inflammation and oxidative stress in the host's infarcted myocardium. Melatonin, an indole, which is produced by many organs including pineal gland, has been shown to protect bone marrow MSCs against apoptosis although the mechanism of action remains elusive. Using a murine model of myocardial infarction (MI), this study was designed to evaluate the impact of melatonin on adipose-derived mesenchymal stem cells (AD-MSCs)-based therapy for MI and the underlying mechanism involved with a focus on silent information regulator 1(SIRT1) signaling...
March 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/26327197/reduced-silent-information-regulator-1-signaling-exacerbates-myocardial-ischemia-reperfusion-injury-in-type-2-diabetic-rats-and-the-protective-effect-of-melatonin
#15
Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu
Diabetes mellitus (DM) increases myocardial oxidative stress and endoplasmic reticulum (ER) stress. Melatonin confers cardioprotective effect by suppressing oxidative damage. However, the effect and mechanism of melatonin on myocardial ischemia-reperfusion (MI/R) injury in type 2 diabetic state are still unknown. In this study, we developed high-fat diet-fed streptozotocin (HFD-STZ) rat, a well-known type 2 diabetic model, to evaluate the effect of melatonin on MI/R injury with a focus on silent information regulator 1 (SIRT1) signaling, oxidative stress, and PERK/eIF2α/ATF4-mediated ER stress...
October 2015: Journal of Pineal Research
https://www.readbyqxmd.com/read/26291611/melatonin-protects-porcine-oocyte-in%C3%A2-vitro-maturation-from-heat-stress
#16
Yu Li, ZhenZhen Zhang, ChangJiu He, KuanFeng Zhu, ZhiYuan Xu, Teng Ma, JingLi Tao, GuoShi Liu
Melatonin is a pleiotropic molecule which plays an important role in animal reproductive activities. Because of the increased global warming, the impact of heat stress (HS) on stockbreeding has become an inevitable issue to be solved. To investigate the potential effects of melatonin on the in vitro maturation of porcine oocyte under the HS, a HS model for porcine oocyte maturation has been used in this study and the different concentrations of melatonin (10(-6) -10(-9)  m) were also tested for their protective effects on oocytes...
October 2015: Journal of Pineal Research
https://www.readbyqxmd.com/read/26094939/melatonin-alleviates-brain-injury-in-mice-subjected-to-cecal-ligation-and-puncture-via-attenuating-inflammation-apoptosis-and-oxidative-stress-the-role-of-sirt1-signaling
#17
Lei Zhao, Rui An, Yang Yang, Xiangmin Yang, Haixiao Liu, Liang Yue, Xia Li, Yan Lin, Russel J Reiter, Yan Qu
Sepsis is a systemic inflammatory response to infection that causes severe neurological complications. Previous studies have suggested that melatonin is protective during sepsis. Additionally, silent information regulator 1 (SIRT1) was reported to be beneficial in sepsis. However, the role of SIRT1 signaling in the protective effect of melatonin against septic encephalopathy remains unclear. This study aimed to investigate the role of SIRT1 in the protective effect of melatonin. EX527, a SIRT1 inhibitor, was used to reveal the role of SIRT1 in melatonin's action...
September 2015: Journal of Pineal Research
https://www.readbyqxmd.com/read/26028291/nuclear-redox-imbalance-affects-circadian-oscillation-in-hacat-keratinocytes
#18
Danilo Ranieri, Daniele Avitabile, Masaki Shiota, Akira Yokomizo, Seiji Naito, Mariano Bizzarri, Maria Rosaria Torrisi
Circadian clock is regulated by a transcriptional/translational feedback loop (TTFL) lasting ∼24 h. Circadian oscillation of peroxiredoxins (PRDX1-6) redox status has been shown in mature erythrocytes. We have recently reported that nuclear levels of PRDX2 are circadian regulated in the HaCaT keratinocytes. In this study, we addressed whether PRDX2 translocation could influence the TTFL. A reporter HaCaT cell line stably expressing the luciferase gene under control of Bmal1 promoter was lentivirally transduced either with an empty vector (EV), a vector carrying a myc-tagged wild type PRDX2 (PRDX2-Myc) or the same gene with a nuclear localization sequence (PRDX2-MycNuc)...
August 2015: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/25975679/melatonin-reverses-h2-o2-induced-premature-senescence-in-mesenchymal-stem-cells-via-the-sirt1-dependent-pathway
#19
Long Zhou, Xi Chen, Tao Liu, Yihong Gong, Sijin Chen, Guoqing Pan, Wenguo Cui, Zong-Ping Luo, Ming Pei, Huilin Yang, Fan He
Mesenchymal stem cells (MSCs) represent an attractive source for stem cell-based regenerative therapy, but they are vulnerable to oxidative stress-induced premature senescence in pathological conditions. We previously reported antioxidant and antiarthritic effects of melatonin on MSCs against proinflammatory cytokines. In this study, we hypothesized that melatonin could protect MSCs from premature senescence induced by hydrogen peroxide (H2 O2 ) via the silent information regulator type 1 (SIRT1)-dependent pathway...
September 2015: Journal of Pineal Research
https://www.readbyqxmd.com/read/25824609/caloric-restriction-resveratrol-and-melatonin-role-of-sirt1-and-implications-for-aging-and-related-diseases
#20
REVIEW
Margarita R Ramis, Susana Esteban, Antonio Miralles, Dun-Xian Tan, Russel J Reiter
Aging is an inevitable and multifactorial biological process. Free radicals have been implicated in aging processes; it is hypothesized that they cause cumulative oxidative damage to crucial macromolecules and are responsible for failure of multiple physiological mechanisms. However, recent investigations have also suggested that free radicals can act as modulators of several signaling pathways such as those related to sirtuins. Caloric restriction is a non-genetic manipulation that extends lifespan of several species and improves healthspan; the belief that many of these benefits are due to the induction of sirtuins has led to the search for sirtuin activators, especially sirtuin 1, the most studied...
March 2015: Mechanisms of Ageing and Development
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